Medical light guide gel with high light guide performance and preparation method thereof

Abstract

The application provides a medical light guide gel with high light guide performance and a preparation method thereof. The medical light guide gel with high light guide performance comprises pure water, glycerol and carbomer, and further comprises aminolevulinic acid propyl ester hydrochloride. The aminolevulinic acid propyl ester hydrochloride is recrystallized, mixed with other components, stirred for 10-15 min, and then the product is prepared by standing. The technical scheme has the technical characteristics of high light penetration, and improves the treatment efficiency and the phototherapy effect.

Description

Technical Field

[0001] This patent application relates to light-guiding gels and methods for their preparation, and more particularly to medical light-guiding gels and methods for their preparation. Background Technology

[0002] Light-guiding gel is an important medical material mainly used in phototherapy. It is a polymer gel product, and its basic components include glycerin, carbomer and pure water. When applied to the surface of the body, it plays a role in guiding light and providing thermal insulation protection. The quality of its light-guiding function directly affects the treatment effect and the scope of medical applications.

[0003] Current medical light-guiding gels mainly consist of purified water, glycerin, and carbomer. To extend shelf life or adjust viscosity, other conventional functional ingredients can be added to the main components, such as ethylparaben for preservative purposes or triethanolamine for viscosity adjustment. However, existing medical light-guiding gel products suffer from limited light-guiding performance, resulting in strict requirements on the application thickness during phototherapy. Exceeding the limit significantly reduces light-guiding performance, severely impacting laser penetration and treatment effectiveness. Insufficient light-guiding performance also limits their application; when applied to the stratum corneum, the laser cannot penetrate to reach the epidermis. Therefore, there is an urgent need for a medical light-guiding gel product with excellent light-guiding properties. Summary of the Invention

[0004] The purpose of this patent application is to effectively improve the light guiding performance of light guide gels, solve the technical problem that the unsatisfactory light guiding performance of existing medical light guide gels directly affects the treatment ability and effect, and provide a medical light guide gel with high light guiding performance and its preparation method.

[0005] The main technical content of the high light-guiding performance medical light-guiding gel technology solution provided in this patent application is: a high light-guiding performance medical light-guiding gel, the components of which include: pure water, glycerin and carbomer, and also includes aminolevulinic acid propyl hydrochloride.

[0006] In one preferred embodiment of the above overall technical solution, the amount of aminolevulinic acid propyl hydrochloride is 1-35N based on the equivalent concentration of the solute mass relative to the gel volume.

[0007] In one preferred embodiment of the above overall technical solution, the amount of aminolevulinic acid propyl hydrochloride is 4-20N based on the equivalent concentration of the solute mass relative to the gel volume.

[0008] In one preferred embodiment of the above overall technical solution, the amount of aminolevulinic acid propyl hydrochloride is 5N based on the equivalent concentration of the solute mass relative to the gel volume.

[0009] In one preferred embodiment of the above overall technical solution, the amount of aminolevulinic acid propyl hydrochloride is 20N based on the equivalent concentration of the solute mass relative to the gel volume.

[0010] One preferred embodiment of the above overall technical solution further includes ethyl p-hydroxybenzoate and triethanolamine.

[0011] In one preferred embodiment of the above overall technical solution, the pure water, glycerin, and carbomer, by volume, are:

[0012] 30-95 parts pure water

[0013] 10-30 parts glycerin

[0014] Carbomer 0.5 to 5 parts.

[0015] In one preferred embodiment of the above overall technical solution, the pure water, glycerin, and carbomer, by volume, are:

[0016] 30-95 parts pure water

[0017] 10-30 parts glycerin

[0018] Carbomer 0.5-5 parts

[0019] 0.001 to 3 parts of ethyl paraben

[0020] Triethanolamine 0.05–15 parts.

[0021] This patent application also provides a method for preparing the aforementioned high-light-guiding medical light-guiding gel, the method being as follows:

[0022] Propyl aminolevulinate hydrochloride was recrystallized to obtain a crystalline dry powder with a water content ≤1% and a purity ≥98%.

[0023] Other components are mixed and stirred until homogeneous to obtain an intermediate mixture;

[0024] Add the crystalline dry powder of aminolevulinic acid propyl hydrochloride to the intermediate mixture, stir for 10-15 minutes, and then let it stand until there are no bubbles to obtain the product.

[0025] This patent application discloses a medical light-guiding gel with high light-guiding performance and its preparation method. The resulting novel light-guiding gel has significantly improved light-guiding performance, overcoming the technical problem that existing light-guiding gels are unable to exert their medical photon therapy effect due to insufficient light-guiding rate when encountering areas with thick skin. It has the technical characteristic of high light penetration in the stratum corneum, scarred skin, and other thicker skin areas, improving treatment efficiency. In particular, it expands the practical need for photon therapy to be applied to delicate skin areas by increasing the coating thickness for treatment. This technical solution also has the technical advantage of uniform light guidance, thereby further ensuring the stability of photon therapy dosage and the efficacy of photon therapy. Detailed Implementation

[0026] The technical content of this patent application will be explained in detail below through the specific content and effects of the following embodiments, but the scope of protection of this application is not limited to the embodiments described.

[0027] In the following embodiments, the composition of this high light-conductivity medical light-conducting gel is described according to the following division:

[0028] ①. Let component A be the recrystallized aminolevulinic acid propyl ester hydrochloride, which is designated as component A as the gel solute and has the molecular formula C8H. 16 NO3Cl, the mass of the solute by weight is 0.024425 kg to 0.5 kg; the recrystallized aminolevulinic acid propyl hydrochloride is freeze-dried after crystallization to obtain a crystalline dry powder with a water content ≤1% and a purity ≥98%;

[0029] ②. Let component B be the gel solvent. A mixture of deionized water, glycerol, and carbomer, stirred for 5 minutes, placed in a container for later use, is designated as component B. The volumetric composition is as follows:

[0030] 2.0475L of deionized water

[0031] Carbomer 0.02L

[0032] 0.375L of glycerin;

[0033] ③. Let component C be the gel solvent. It is a mixture based on component B, with the addition of ethylparaben. Stir for about 5 minutes, place in a container for later use, and set as component C. The amount of ethylparaben added is 0.001 to 3 parts by volume. In this example, 0.0075 L is used.

[0034] ④. Let component D be the gel solvent. It is a mixture based on component C with the addition of triethanolamine. Stir for about 5 minutes and place it in a container for later use. This is designated as component D. The amount of component D added by volume is 0.05 to 15 L. In this example, 0.05 L is selected.

[0035] The above examples illustrate the mixing of component A with different solute masses and the solvent masses of components B, C, and D. After mixing, the mixture was stirred for 15 minutes, which could be completed using a water bath-type two-way stirring gelation vessel. The mixture was then allowed to stand until no air bubbles were present, resulting in four types of gel samples. The transmittance data for each type are shown in Tables 1-3 below.

[0036] Table 1

[0037]

[0038] Table 2

[0039]

[0040]

[0041] Table 3

[0042]

[0043] As can be seen from the above examples, the light transmittance of the new light guide gel obtained by adding aminolevulinic acid propyl hydrochloride to the existing light guide gel composition is significantly improved.

[0044] Taking into account both ensuring high light transmittance and safety and heat insulation performance, the suitable equivalent concentration of aminolevulinic acid propyl hydrochloride is 1-35N, of which the preferred equivalent concentration is 4-20N.

[0045] For light-guiding gels applied to normal skin or sensitive mucous membrane skin, the equivalent concentration of aminolevulinic acid propyl hydrochloride is preferably 5N, while for applications with a more pronounced stratum corneum, 20N is preferred.

Claims

1. A medical light-guiding gel with high light-guiding properties, comprising the following components: Pure water, glycerol and carbomer, characterized in that it also contains propyl aminolevulinate hydrochloride.

2. The medical light-guiding gel with high light-guiding performance according to claim 1, characterized in that, The aminolevulinic acid propyl ester hydrochloride is used as a light-guiding gel solute, and its equivalent concentration is 1-35N.

3. The medical light-guiding gel with high light-guiding performance according to claim 1, characterized in that, The aminolevulinic acid propyl hydrochloride is used as a light guide gel solute, and its equivalent concentration is 4-20N.

4. The medical light-guiding gel with high light-guiding performance according to claim 1, characterized in that, The aminolevulinic acid propyl ester hydrochloride is used as the optical guide gel solute, and its equivalent concentration is 5N.

5. The medical light-guiding gel with high light-guiding performance according to claim 1, characterized in that, The aminolevulinic acid propyl hydrochloride is used as a light guide gel solute with an equivalent concentration of 20N.

6. The medical light-guiding gel with high light-guiding performance according to claim 1, 2, 3, 4 or 5, characterized in that, Its gel solvent composition also includes ethyl p-hydroxybenzoate and triethanolamine.

7. The medical light-guiding gel with high light-guiding performance according to claim 1, 2, 3, 4 or 5, characterized in that, The pure water, glycerin, and carbomer mentioned herein, by volume, are as follows: 30-95 parts deionized water Glycerin 10-30 parts Carbomer 0.5 to 5 parts.

8. The medical light-guiding gel with high light-guiding performance according to claim 7, characterized in that, The deionized water, glycerin, and carbomer, by volume, are: 30-95 parts pure water Glycerin 10-30 parts Carbomer 0.5–5 parts 0.001 to 3 parts of ethyl paraben Triethanolamine 0.05–15 parts.

9. A method for preparing a medical light-guiding gel with high light-guiding performance, comprising using a medical light-guiding gel with high light-guiding performance as described in claims 1-8, characterized in that, The method is as follows: Propyl aminolevulinate hydrochloride was recrystallized to obtain a crystalline dry powder with a water content ≤1% and a purity ≥98%. Other components are mixed and stirred until homogeneous to obtain an intermediate mixture; Add the crystalline dry powder of aminolevulinic acid propyl hydrochloride to the intermediate mixture, stir for 10-15 minutes, and then let it stand until there are no bubbles to obtain the product.

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