A blood product dispensing stopper system

Abstract

The present invention relates to the technical field of blood product production equipment, and specifically to a blood product separation and plugging system. The present invention provides a blood product separation and plugging system, comprising a bottle sorting mechanism, a turntable, a pipetting mechanism, an automatic capping device, a plugging device and a material unloading platform, wherein the bottle sorting mechanism, the pipetting mechanism, the automatic capping device, the plugging device and the material unloading platform are sequentially arranged around the turntable; the pipetting mechanism comprises a driving guide rail, a pusher and a pipette, the pusher is mounted on the driving guide rail, the pipette is mounted on the pusher, and the driving guide rail drives the pusher to move along the length direction of the driving guide rail. The system does not require disinfection of the pipeline, and the liquid separation is more sterile, so that the blood product separation is pollution-free, and also avoids errors caused by manual operation, and the quantification is more accurate, without the need for repeated manual operation, with a high degree of automation, improved production efficiency and reduced production costs.

Description

Technical Field

[0001] The present invention relates to the technical field of blood product production equipment, and in particular to a hydraulic plug system for blood products. Background Art

[0002] Blood products fall under the category of biological products, made from healthy human blood using biological processes or separation and purification techniques. They are used clinically for passive immunization and play an irreplaceable role in the treatment and prevention of a wide range of diseases. In clinical testing, blood products serve as matrices for quality control products and are essential components of test kits used to measure various human medical indicators.

[0003] Currently, the preparation process for blood products remains semi-automated. Specifically, blood product separation relies primarily on two methods: First, manual separation using an electric continuous dispenser. This is subject to significant errors, making quantitative and precise separation impossible and inefficient. Second, separation relies on pipelines, which require replacement and disinfection after each batch of separation. This is complex, incomplete, and potentially contaminating. Summary of the Invention

[0004] (1) The problems to be solved by the present invention are: First, when separating blood products, separation is currently performed manually using an electric continuous liquid dispenser, which has large manual operation errors, cannot achieve quantitative and accurate liquid separation, and has low work efficiency; second, separation is performed using pipelines, and the pipelines need to be replaced and disinfected after each batch of separation. The operation is complicated, the disinfection cannot be done thoroughly, and there is contamination.

[0005] (2) Technical solution

[0006] A blood product separation and plugging system comprises a bottle unscrambling mechanism, a turntable, a liquid transfer mechanism, an automatic capping device, a plugging device and a material unloading platform, wherein the bottle unscrambling mechanism, the liquid transfer mechanism, the automatic capping device, the plugging device and the material unloading platform are sequentially arranged around the turntable;

[0007] The pipetting mechanism includes a driving guide rail, a pushing member and a pipette, the pushing member is installed on the driving guide rail, the pipette is installed on the pushing member, the driving guide rail drives the pushing member to move along the length direction of the driving guide rail, and the pushing member drives the pipette to move up and down, and one end of the driving guide rail is located directly above the turntable.

[0008] According to one embodiment of the present invention, the blood product dispensing and plugging system further comprises a base, and the bottle unscrambling mechanism, turntable, pipetting mechanism, automatic capping device and plugging device are all mounted on the base;

[0009] A support member is installed on the base, and the support member is connected to the driving guide rail for supporting the driving guide rail.

[0010] According to one embodiment of the present invention, a liquid storage bottle, a gun tip box and a storage box are provided on the base. The liquid storage bottle, the gun tip box and the storage box are arranged on one side of the driving guide rail along the length direction of the driving guide rail. The gun tip box is used to place the gun tip of the pipette, and the storage box is used to collect discarded gun tips.

[0011] According to one embodiment of the present invention, the blood product hydraulic plugging system further comprises a semi-plugging device, the automatic capping device comprises a cap sorter and a capping track, and the end of the capping track is connected to the semi-plugging device;

[0012] The automatic capping device is used to transport the rubber stopper to the semi-stoppering device, and the semi-stoppering device is used to insert the rubber stopper into the vial on the turntable.

[0013] According to one embodiment of the present invention, the semi-plugging device includes a shaft seat, an arc-shaped tube, a plugging piece, an air source mechanism, a driving mechanism and a plugging slide rail;

[0014] The plugging piece is rotatably mounted on the shaft seat, and the cross-section of the plugging piece is a quarter circle. The driving mechanism drives the plugging piece to rotate around the axis of the plugging piece. The arc tube is mounted on the outer side of the plugging piece, and the arc tube and the plugging piece are coaxially arranged. The first end surface of the arc tube is provided with an air hole, and the rubber plug is sucked through the air hole. The air source mechanism is connected to the arc tube;

[0015] The plugging slide rail is vertically installed on the shaft seat, and a track groove for accommodating the rubber plug is formed in the plugging slide rail. The lower end of the plugging slide rail is located above the arc tube.

[0016] According to one embodiment of the present invention, a drive shaft is rotatably mounted on the shaft seat, the drive shaft is fixedly connected to the plugging piece, and the drive shaft and the plugging piece are coaxially arranged; the driving mechanism includes a motor and a coupling, and the output end of the motor is connected to the drive shaft through a coupling.

[0017] According to one embodiment of the present invention, the arc tube intersects with the lower end of the plugging slide rail, and when the arc tube rotates to the first extreme position, the first end surface of the arc tube is flush with the track groove.

[0018] According to one embodiment of the present invention, the air source mechanism includes a hose, an air pump and a one-way throttle valve, one end of the hose is connected to the arc tube, and the hose is communicated with the arc tube, the other end of the hose is connected to the one-way throttle valve, and the one-way throttle valve is connected to the air pump.

[0019] According to one embodiment of the present invention, a plurality of grooves are evenly provided on the side of the turntable, a channel plate is installed on the base, a circular hole is provided on the channel plate, the turntable is coaxially arranged in the circular hole, a feed notch and a discharge notch are respectively provided on the channel plate, and the feed notch and the discharge notch are both connected to the circular hole.

[0020] According to one embodiment of the present invention, the bottle unscrambling mechanism includes a disc, a fence, a column and a curved rod, the channel plate is higher than the disc, and the feeding notch is located at the edge of the disc;

[0021] The unloading platform is lower than the channel plate, and one side of the unloading platform is located directly below the discharge notch;

[0022] The central angle corresponding to the fence is greater than 120°, the fence is coaxial with the disc, the fence is higher than the disc, and one end of the fence is connected to the channel plate;

[0023] The column and the disc are coaxially arranged and rotatably connected to each other. The curved rod is installed on the side of the column, and a channel is formed between the rod end of the curved rod and the fence.

[0024] Beneficial effects of the present invention:

[0025] The present invention provides a blood product dispensing and plugging system, which includes a bottle unscrambling mechanism, a turntable, a pipetting mechanism, an automatic capping device, a plugging device and a material unloading platform. The bottle unscrambling mechanism, the pipetting mechanism, the automatic capping device, the plugging device and the material unloading platform are arranged in sequence around the turntable; the pipetting mechanism includes a driving guide rail, a pushing member and a pipette, the pushing member is installed on the driving guide rail, and the pipette is installed on the pushing member. The driving guide rail drives the pushing member to move along the length direction of the driving guide rail, and the pushing member drives the pipette to move up and down. One end of the driving guide rail is located directly above the turntable.

[0026] The driving guide rail drives the pushing member and the pipette to move along the driving guide rail toward the liquid storage bottle until it moves to just above the liquid storage bottle. At this time, the pushing member pushes the pipette downward until the tip of the pipette penetrates into the liquid storage bottle, and the pipette extracts the liquid in the liquid storage bottle. Then the pushing member shortens and drives the pipette to reset. Then the driving guide rail drives the pushing member and the pipette to move toward the turntable until the pipette moves to just above the vial to be added. The driving guide rail pauses, and the pushing member pushes the pipette downward again so that the tip of the pipette penetrates into the vial. Then the pipette injects the liquid into the vial. After that, the pushing member shortens and drives the pipette to reset again, completing a liquid dispensing process.

[0027] When using a pipette and a gun tip for liquid separation operations, when separating different types of blood products, you only need to replace the gun tip, and there is no need to disinfect the pipeline. This avoids the problem of liquid contamination caused by incomplete pipeline disinfection, and the separation is more sterile, making the separation of blood products pollution-free and improving production efficiency.

[0028] Since the pipette is used in conjunction with a pusher and a drive guide to perform liquid dispensing operations, errors caused by manual operation are avoided, the quantification is more accurate, repeated manual operation is unnecessary, the degree of automation is high, production efficiency is improved, and production costs are reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the specific embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0030] Figure 1 A top view of an embodiment of the present invention;

[0031] Figure 2 A structural diagram of an embodiment of the present invention with the body and base removed;

[0032] Figure 3 A structural diagram of the channel plate, turntable, pipetting mechanism, automatic capping device, and plugging device provided in an embodiment of the present invention;

[0033] Figure 4 A three-dimensional diagram of a semi-plugging device provided in an embodiment of the present invention;

[0034] Figure 5 A front view of a semi-pressing plug device provided in an embodiment of the present invention;

[0035] Figure 6A side view of a semi-plugging device provided in an embodiment of the present invention.

[0036] Icons: 1-body; 2-bottle unscrambling mechanism; 201-disc; 202-column; 203-bending rod; 204-rod sleeve; 205-fence; 3-semi-plug device; 301-one-way throttle valve; 302-base plate; 303-height adjustment plate; 304-mounting plate; 305-vertical plate; 306-motor; 307-coupling; 308-shaft seat; 309-arc tube; 310-bracket; 311-plugging rubber Slide rail; 312-stopper; 4-turntable; 5-pipetting mechanism; 501-drive rail; 502-pipette; 6-channel plate; 601-feed notch; 602-discharge notch; 7-automatic cover drop device; 8-stopper device; 9-unloading platform; 10-ultraviolet disinfection lamp; 11-control panel; 12-partition; 13-liquid storage bottle; 14-gun tip box; 15-storage box; 16-extension platform; 17-infrared sensor. DETAILED DESCRIPTION

[0037] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0038] like Figures 1-6 As shown, one embodiment of the present invention provides a blood product separation and plugging system, comprising a bottle unscrambling mechanism 2, a turntable 4, a pipetting mechanism 5, an automatic capping device 7, a plugging device 8, and a feeding platform 9. The bottle unscrambling mechanism 2, the pipetting mechanism 5, the automatic capping device 7, the plugging device 8, and the feeding platform 9 are sequentially arranged around the turntable 4.

[0039] The pipetting mechanism 5 includes a driving guide rail 501, a pushing member and a pipette 502. The pushing member is installed on the driving guide rail 501, and the pipette 502 is installed on the pushing member. The driving guide rail 501 drives the pushing member to move along the length direction of the driving guide rail 501, and the pushing member drives the pipette 502 to move up and down. One end of the driving guide rail 501 is located directly above the turntable 4.

[0040] In this embodiment, a liquid storage bottle 13 is placed on one side of the driving guide rail 501, and the bottle mouth of the liquid storage bottle 13 is opened. The driving guide rail 501 drives the pusher and the pipette 502 to move along the driving guide rail 501 toward the liquid storage bottle 13 until they move to just above the liquid storage bottle 13. At this time, the pusher pushes the pipette 502 to move downward until the tip of the pipette 502 penetrates into the liquid storage bottle 13, and the pipette 502 extracts the liquid in the liquid storage bottle 13, and then the pusher shortens and drives the pipette 502 to move downward. The pipette 502 is reset, and then the guide rail 501 is driven to drive the pusher and the pipette 502 to move toward the turntable 4 until the pipette 502 moves to the top of the vial to be dripped. The guide rail 501 is driven to stop working, and the pusher pushes the pipette 502 downward again so that the tip of the pipette 502 goes deep into the vial. The pipette 502 then injects the liquid into the vial. After that, the pusher is shortened to drive the pipette 502 to reset again, completing one liquid dispensing process.

[0041] Compared with manual liquid separation using an electric continuous liquid dispenser, the present embodiment uses a pipette 502 in conjunction with a pusher and a drive guide rail 501 to perform liquid separation operations, thereby avoiding errors caused by manual operation, making quantification more accurate, eliminating the need for repeated manual operation, and having a high degree of automation, thereby improving production efficiency and reducing production costs.

[0042] Compared with using pipelines for liquid separation, this embodiment only requires replacing the gun tip when separating different types of blood products, without the need to disinfect the pipeline, avoiding the problem of liquid contamination caused by incomplete pipeline disinfection. The liquid separation is more sterile, making the blood product separation pollution-free and improving production efficiency.

[0043] Preferably, the driving guide rail 501 is a motor linear module, which can be a synchronous belt linear module, a ball screw linear module or a linear guide rail.

[0044] Furthermore, the pusher is a pneumatic cylinder, which is vertically mounted on the sliding block of the motor linear module. The pipette 502 is mounted at the bottom end of the cylinder. The cylinder moves along with the sliding block on the drive rail 501, allowing it to reciprocate between the turntable 4 and the liquid storage bottle 13. At the same time, the cylinder extends or contracts to drive the pipette 502 up and down, allowing it to enter or exit the vial. This allows the entire liquid dispensing operation to be completed automatically, eliminating the need for manual operation and improving work efficiency.

[0045] Optionally, the pushing member may also be an electric push rod or a hydraulic cylinder, as long as it can drive the liquid storage bottle 13 to move up and down.

[0046] In this embodiment, if Figure 1 As shown, the bottle unscrambling mechanism 2, the turntable 4, the liquid transfer mechanism 5, the automatic capping device 7, the semi-plugging device 3 and the plugging device 8 are all installed on the base. Figure 1From the perspective of , in the counterclockwise direction of the turntable 4, the bottle sorting mechanism 2, the pipetting mechanism 5, the automatic capping device 7, the plugging device 8 and the unloading platform 9 are arranged in sequence around the turntable 4, wherein the driving guide rail 501 is higher than the turntable 4, and one end of the driving guide rail 501 is located directly above the turntable 4, so that the pipette 502 can be moved to directly above the vial.

[0047] Furthermore, a support member is mounted on the base, the support member being arranged perpendicular to the base, and the drive rail 501 is mounted on the support member. Specifically, in this embodiment, the support member is a support rod, which is fixedly connected to the right side of the drive rail 501. A flange is welded to the bottom of the support rod, and the flange is fixed to the upper surface of the base by bolts, facilitating the removal of the support rod.

[0048] Optionally, the support member may also be other mechanisms that can play a supporting role, and no specific limitation is made here.

[0049] Preferably, Figure 3 As shown, the pipette 502 is located on the left side of the driving guide rail 501, and a liquid storage bottle 13, a gun tip box 14 and a storage box 15 are provided on the base. The liquid storage bottle 13, the gun tip box 14 and the storage box 15 are arranged on the left side of the driving guide rail 501 along the length direction of the driving guide rail 501, and the liquid storage bottle 13 is located directly below the travel path of the pipette 502, so that the pipette 502 can smoothly extract liquid.

[0050] It should be noted that the tip box 14 has multiple, mutually separated cavities for storing tips. When different blood products need to be separated, the tips need to be replaced to avoid contamination. At this time, the tips on the pipette 502 are removed and the discarded tips are placed in the storage box 15. The pipette 502 then removes new tips from the tip box 14 to complete the replacement. The discarded tips are stored in the storage box 15 for subsequent centralized disposal, thus avoiding the problem of liquid contamination caused by shared pipes.

[0051] Preferably, a control panel 11 is installed on the base, and the drive rail 501, the pusher and the pipette 502 are all electrically connected to the control panel 11. The operation of the drive rail 501, the pusher and the pipette 502 is controlled by the control panel 11, so that the entire liquid separation process can be strictly operated according to the set program.

[0052] Preferably, Figure 3 As shown, the semi-pressing device 3 is close to the automatic cover-dropping device 7, which includes a cover sorter and a cover track, and the end of the cover track is connected to the semi-pressing device 3;

[0053] Specifically, the cap sorter arranges the rubber stoppers in an orderly manner and transports them to the cap track. The cap sorter includes an electromagnetic vibrator and a cap storage tray with a cap sorting mechanism. The vibrator uses centrifugal force to effectively align the rubber stoppers in the required production direction. The rubber stoppers in the cap track then move in an orderly manner along the direction of the cap track. Both the cap sorter and cap track are existing equipment, so their specific working principles will not be described in detail.

[0054] It is worth noting that in this embodiment, the semi-plugging device 3 is placed directly below the upper cover track, and the lower end of the upper cover track is connected to the semi-plugging device 3, so that the rubber stoppers in the upper cover track can be sorted and enter the semi-plugging device 3 in sequence, so that the semi-plugging device 3 can insert the rubber stoppers into the syringe bottles in sequence.

[0055] Preferably, Figure 4 、 Figure 5 and Figure 6 As shown, the semi-plugging device 3 includes a mounting plate 304, a shaft seat 308, an arc tube 309, a plugging piece 312, an air source mechanism, a driving mechanism and a plugging rubber slide rail 311;

[0056] Among them, the mounting plate 304 is a rectangular plate, the shaft seat 308 is on one side of the mounting plate 304, and a vertical plate 305 is provided on the upper surface of the mounting plate 304, and the vertical plate 305 is perpendicular to the mounting plate 304. The driving mechanism is installed on the vertical plate 305, and a driving shaft is rotatably installed on the shaft seat 308. The driving mechanism is connected to the driving shaft and is used to drive the driving shaft to rotate. The cross-section of the plugging piece 312 is a quarter circle, and the plugging piece 312 is fixedly mounted on the driving shaft, and the plugging piece 312 is coaxially arranged with the driving shaft, so that the driving mechanism can drive the plugging piece 312 to rotate around the axis of the plugging piece 312, and the arc tube 309 is installed on the outer side of the plugging piece 312, and the arc tube 309 is coaxially arranged with the plugging piece 312, and the central angle corresponding to the arc tube 309 is 90 degrees.

[0057] Furthermore, an air hole is provided on the first end surface of the arc tube 309, through which the rubber plug can be sucked, and the air source mechanism is connected to the arc tube 309;

[0058] The plugging rubber slide rail 311 is vertically mounted on the shaft seat 308 . A track groove for receiving the rubber plug is formed in the plugging rubber slide rail 311 . The lower end of the plugging rubber slide rail 311 is located above the arc tube 309 .

[0059] The rubber stoppers are arranged in order and transported to the upper cover track by the cover sorter, and then the rubber stoppers in the upper cover track enter the stopper rubber slide rail 311 in turn. In the initial state, the first end face of the arc tube 309 is flush with the stopper rubber slide rail 311. As the rubber stopper moves downward, the bottom rubber stopper moves to the first end face of the arc tube 309. As the air source mechanism is opened, the rubber stopper is sucked into the air hole on the first end face of the arc tube 309, and then the driving mechanism drives the stopper piece 312 and the arc tube 309 to rotate 90°, so that the first end face of the arc tube 309 is adjusted from a vertical state to a horizontal state, thereby adjusting the rubber stopper to a vertical state, and thus inserting the rubber stopper into the syringe bottle.

[0060] Afterwards, the air source mechanism cuts off the air, and the arc tube 309 no longer absorbs the rubber stopper. Then the driving mechanism drives the plugging piece 312 and the arc tube 309 to reverse 90 degrees, so that the plugging piece 312 and the arc tube 309 are reset to absorb the next rubber stopper.

[0061] It should be noted that, in the past, the rubber stopper was directly dropped by the upper cover track of the automatic cap dropping device 7. Since the rubber stopper itself is elastic, when the upper cover track of the automatic cap dropping device 7 drops, the rubber stopper is only affected by gravity and is difficult to be inserted into the bottle mouth of the syringe bottle. In this way, when the syringe bottle moves with the turntable 4 later, the rubber stopper is easy to fall off the syringe bottle, and when the height between the lower end of the upper cover track and the bottle mouth of the syringe bottle is slightly higher, the rubber stopper often pops out of the bottle mouth of the syringe bottle.

[0062] Compared with the conventional method of using the automatic capping device 7 to drop the rubber stopper onto the vial, this embodiment has at least the following advantages:

[0063] First, the driving mechanism drives the stopper piece 312 and the arc tube 309 to rotate, thereby inserting the rubber stopper into the vial. Since a downward force is applied to the rubber stopper, the rubber stopper can be inserted into the bottle mouth of the vial. When the vial moves with the turntable 4, the position of the rubber stopper will not shift, nor will it fall off the vial, which provides a guarantee for the subsequent operation of the stoppering device 8.

[0064] Secondly, it can ensure that the rubber stopper is inserted into the bottle mouth of the vial, and the problem of the rubber stopper popping out of the vial will not occur.

[0065] Preferably, Figure 4 As shown, the driving mechanism includes a motor 306 and a coupling 307. The motor 306 is fixedly mounted on the vertical plate 305. The output end of the motor 306 is rotationally connected to the vertical plate 305. The output end of the motor 306 is connected to the drive shaft through the coupling 307. In this way, the motor 306 can drive the drive shaft to rotate, thereby driving the plugging plate 312 to rotate.

[0066] Further, such as Figure 4and Figure 6 As shown, a bracket 310 is installed on the back of the shaft seat 308, and the plugged rubber slide rail 311 is fixed on the bracket 310 by screws, thereby fixing the plugged rubber slide rail 311.

[0067] Preferably, a track groove is provided on the front side of the plugging rubber slide rail 311 along the length direction of the plugging rubber slide rail 311, and the width of the track groove is slightly smaller than the diameter of the rubber plug, that is, there is friction between the rubber plug and the inner wall of the track groove, so that in a natural state, the rubber plug will not fall off, and the upper end of the plugging rubber slide rail 311 is connected to the lower end of the upper cover track of the automatic cover dropping device 7. As the rubber cover in the upper cover track enters the plugging rubber slide rail 311 in turn, the rubber plug in the plugging rubber slide rail 311 is squeezed, so that the rubber plug in the plugging rubber slide rail 311 moves downward in turn, thereby ensuring that the rubber plug in the plugging rubber slide rail 311 can move downward in an orderly manner, to ensure that each time the arc tube 309 is reset, just one rubber plug can be sucked.

[0068] It should be noted that the rubber stopper includes a plug head and a plug rod. The diameter of the plug head is larger than the diameter of the plug rod, and the two are coaxially arranged. The plug rod is inserted into the bottle mouth of the syringe bottle, while the rubber stopper in the stopper rubber slide 311 has a plug head in contact with the groove surface of the track groove, the plug rod does not contact the track groove, and the plug rod faces the front of the stopper rubber slide 311.

[0069] When the arc tube 309 is reset and absorbs the rubber stopper, the air hole of the arc tube 309 absorbs the plug head of the rubber stopper, and then the arc tube 309 rotates 90 degrees so that the plug column of the rubber stopper can be inserted into the vial.

[0070] Preferably, Figure 6 From the perspective of , the arc tube 309 intersects with the lower end of the plugging rubber slide rail 311, that is, when the arc tube 309 rotates 90° clockwise, the arc surface of the arc tube 309 is always located in the track groove, and the rubber plug will not fall from the track groove when the arc tube 309 rotates clockwise. Then the arc tube 309 rotates 90° counterclockwise, and the rubber plug arc tube 309 rotates to the first extreme position. At this time, the first end surface of the arc tube 309 is flush with the track groove, the arc tube 309 no longer blocks the track groove, and the rubber plug can fall smoothly.

[0071] Specifically, Figure 6 From the perspective of , the lower end face of the arc tube 309 is the first end face, and the air hole is opened on the first end face. When the arc tube 309 is rotated 90° counterclockwise, the first end face of the arc tube 309 is flush with the inner groove surface of the track groove.

[0072] Preferably, the air source mechanism includes a hose, a one-way throttle valve 301, and a valve body. A circular hole is formed on the side of the arc tube 309, communicating with the lumen of the arc tube 309. The second end of the arc tube 309 is sealed, and an air hole is formed on its first end surface. One end of the hose is sealedly connected to the circular hole in the arc tube 309, and the other end of the hose is connected to the one-way throttle valve 301. The one-way throttle valve 301 is connected to a vacuum pump. The vacuum pump extracts air from the arc tube 309, creating negative pressure at the air hole in the arc tube 309, thereby sucking the rubber stopper. The air path is controlled by a controller to open and close the one-way throttle valve 301.

[0073] Since the semi-plugging operation is performed by cooperating with the automatic plug-dropping device 8 and the semi-plugging device 3, the rubber stopper can be smoothly inserted into the bottle mouth of the vial without deflection or falling off the vial, thereby avoiding the problem of the rubber stopper popping out of the vial. The automated operation of inserting the rubber stopper into the vial is realized, thereby improving production efficiency.

[0074] Optional, such as Figure 4 and Figure 5 As shown, a base plate 302 is installed on the channel plate 6, and a plurality of height adjustment plates 303 are stacked on the base plate 302, and the mounting plate 304 is placed on the height adjustment plate 303. According to actual conditions, the thickness of the height adjustment plate 303 can be appropriately adjusted to adjust the height of the semi-plugging device 3 to adapt to different specifications of vials.

[0075] In this embodiment, if Figure 3 As shown, a plurality of grooves are evenly provided on the side of the turntable 4. The cross-section of the groove is semicircular and completely passes through the turntable 4. A channel plate 6 is installed on the base. A circular hole is provided on the channel plate 6. The turntable 4 is coaxially arranged in the circular hole. The upper surface of the channel plate 6 is flush with the upper surface of the turntable 4. A feed notch 601 and a discharge notch 602 are respectively provided at the upper left corner and the upper right corner of the channel plate 6. The feed notch 601 and the discharge notch 602 are both connected to the circular hole.

[0076] Furthermore, the automatic capping device 7 and the plugging device 8 are sequentially arranged between the pipetting mechanism 5 and the discharge notch 602, and the semi-plugging device 3 is installed on the channel plate 6 and close to the automatic capping device 7. The vial is first transferred to the semi-plugging device 3, and the semi-plugging device 3 inserts the rubber stopper into the mouth of the vial. At this time, only half of the rubber stopper is inserted into the vial. After that, when the turntable 4 drives the vial to rotate to the working position of the plugging device 8, the vial is located directly below the plugging column of the plugging device 8, and then the plugging device 8 presses the rubber stopper at the mouth of the vial into the vial, so that the rubber stopper seals the bottle mouth.

[0077] It should be noted that the vial enters the groove on the turntable 4 from the feed notch 601 at the upper left corner of the channel plate 6. As the turntable 4 rotates counterclockwise, the vial rotates counterclockwise with the turntable 4 until it reaches the set position. The turntable 4 stops rotating, and then the pipette 502 moves to the position just above the set position and injects liquid into the vial. After that, the turntable 4 continues to rotate to the next position and stops. The automatic capping device 7 transports the rubber cap to the stoppering rubber slide 311, and then The semi-stoppering device 3 is used to insert the rubber stopper into the bottle mouth of the vial, and the turntable 4 drives the vial to continue rotating to the stoppering device 8 and stop. The stoppering device 8 gently beats the rubber stopper from above to adjust the misaligned rubber stopper to a correct state. At this time, only half of the rubber stopper is inserted into the vial, and then the turntable 4 rotates the vial to the discharge notch 602. The vial enters the discharge notch 602 and then enters the unloading platform 9. The vial is then freeze-dried.

[0078] It should be noted that the purpose of using the plugging device 8 to hammer the rubber stopper and insert half of the rubber stopper into the vial is to facilitate the subsequent freeze-drying operation.

[0079] Preferably, the plugging device 8 includes a mounting bracket and a plugging driver. The mounting bracket is mounted on the channel plate 6, and the plugging driver is vertically mounted on the mounting bracket. The plugging driver can extend and shorten in the vertical direction. When the vial moves to the bottom of the plugging device 8, the plugging driver extends and applies pressure toward the rubber stopper on the vial, thereby inserting half of the rubber stopper on the vial into the vial, and then the plugging driver shortens and returns to its original position.

[0080] The plugging device 8 is an existing device, so its specific working principle will not be described in detail.

[0081] Preferably, in this embodiment, Figure 3 As shown, two infrared sensors 17 are installed on the upper surface of the channel plate 6. For the convenience of description, the two infrared sensors 17 are named the first infrared sensor and the second infrared sensor. The first infrared sensor is close to the feed notch 601. When the syringe bottle enters the groove of the turntable 4 from the feed notch 601, the infrared light emitted by the first infrared sensor just shines on the syringe bottle. The first infrared sensor receives the signal and sends the signal to the control panel 11, indicating that the syringe bottle has entered the groove of the turntable 4. Then the control panel 11 controls the turntable 4 to continue rotating and controls the pipetting mechanism 5 to start the liquid dispensing operation.

[0082] In this embodiment, the second infrared sensor is used to detect whether the penicillin bottle has reached the liquid dispensing station. Specifically, when the turntable 4 drives the penicillin bottle to rotate counterclockwise from the feed notch 601 to the liquid dispensing station, the infrared light emitted by the second infrared sensor just shines on the penicillin bottle, indicating that the penicillin bottle has reached the specified position. The pusher can drive the pipette 502 to move downward to inject liquid into the penicillin bottle, avoiding the situation where the tip of the pipette 502 is misaligned with the penicillin bottle due to errors in the position of the penicillin bottle.

[0083] The first infrared sensor and the second infrared sensor are both electrically connected to the control panel 11 , and the control panel 11 receives signals sent by the first infrared sensor and the second infrared sensor.

[0084] Preferably, Figure 2 As shown, the bottle unscrambling mechanism 2 is located on the left side of the channel plate 6, and the unloading platform 9 is located on the right side of the channel plate 6. The bottle unscrambling mechanism 2 includes a disc 201. The channel plate 6 is higher than the disc 201. A part of the right side of the disc 201 is located directly below the channel plate 6. Specifically, the feed notch 601 is located directly above the edge of the disc 201. In this way, as the disc 201 rotates, the vials at the edge of the disc 201 can be smoothly rotated into the feed notch 601.

[0085] It should be noted that the unloading platform 9 is lower than the channel plate 6, the left side of the unloading platform 9 is located directly below the discharge notch 602, and the upper surface of the unloading platform 9 is flush with the lower surface of the channel plate 6 or slightly lower than the lower surface of the channel plate 6. In this way, when the syringe bottle in the turntable 4 enters the discharge notch 602, the bottom of the syringe bottle will contact the upper surface of the unloading platform 9, and the unloading platform 9 will support the syringe bottle.

[0086] Preferably, Figure 3 As shown, a barrier member 12 is installed on the channel plate 6 near the discharge notch 602, and one end of the barrier member 12 is located directly above the turntable 4. When the turntable 4 drives the vial to rotate to the feed notch 601, it is blocked by the barrier member 12. When the turntable 4 continues to rotate, the vial will enter the feed notch 601 through the groove on the turntable 4.

[0087] In this embodiment, if Figure 2 As shown, the bottle unscrambling mechanism 2 further includes a fence 205 , a column 202 and a curved rod 203 . The central angle corresponding to the fence 205 is greater than 120°. The fence 205 is coaxially arranged with the disc 201 and is higher than the disc 201 .

[0088] Optionally, the central angle corresponding to the fence 205 is 180°.

[0089] Preferably, the upright post 202 is coaxially disposed with the disk 201 and is rotatably connected to the disk 201. The curved rod 203 is mounted on the side of the upright post 202, and the cross-section of the curved rod 203 and the upright post 202 forms a comma-shaped structure. A passage for a vial to pass through is formed between the end of the curved rod 203 and the inner side of the fence 205. The width of this passage is slightly larger than the diameter of the vial and can accommodate only one vial at most. Furthermore, as the area enclosed by the curved rod 203 and the left side wall of the fence 205 decreases, the vials on the disk 201 gradually gather together as the disk 201 rotates clockwise.

[0090] Optionally, a rod sleeve 204 is sleeved on the rod end of the curved rod 203. The rod sleeve 204 is a plastic sleeve. The plastic sleeve itself has low hardness and will not scratch the vial.

[0091] Optionally, the rod sleeve 204 may be a rubber sleeve, which has good deformation ability and is less likely to damage the vial when in contact with the vial.

[0092] Preferably, an extension platform 16 is installed in front of the disc 201. The surface of the extension platform 16 is flush with the upper surface of the disc 201. The inner side surface of the extension platform 16 is an arc-shaped surface, which contacts the side surface of the disc 201. One end of the fence 205 is connected to the channel plate 6, and the other end of the fence 205 is connected to the extension platform 16. The extension platform 16 is used to place the syringe bottle.

[0093] Specifically, the staff pushes the vials on the extension platform 16 to the edge of the disc 201. The vials rotate clockwise as the disc 201 rotates clockwise, and gradually rotate to the channel for the vials to pass through. Since the area enclosed by the curved rod 203 and the left side wall of the fence 205 becomes smaller and smaller, the vials on the disc 201 gradually gather together as the disc 201 rotates clockwise. Because the channel can only accommodate one vial at a time, as the disc 201 continues to rotate, the vials pass through the channel one by one, and then enter the feed gap 601 in sequence.

[0094] And since the rotation speed of the disk 201 is set according to the rotation speed of the turntable 4, Figure 2 As shown, when the groove at the feed port on the turntable 4 rotates counterclockwise to the next position, the vial closest to the feed notch 601 on the disc 201 just enters the feed notch 601, thereby pushing the frontmost vial out of the feed notch 601, and then the vial also enters the groove on the turntable 4.

[0095] Preferably, Figure 1As shown, the blood product separation and plugging system also includes a body 1, a sealed chamber is formed inside the body 1, and the base, bottle unscrambling mechanism 2, pipetting mechanism 5, automatic cover-dropping device 7, plugging device 8 and unloading platform 9 are all arranged in the sealed chamber, and a plurality of ultraviolet disinfection lamps 10 are installed on the inner wall of the sealed chamber. Deep sterilization is performed by the ultraviolet disinfection lamps 10 to ensure a sterile working environment.

[0096] Preferably, a double door is installed on the front of the body 1, and the double door is a glass door, so that outsiders can observe the working conditions inside the body 1 through the glass door.

[0097] In the description of the present invention, it should be noted that the terms "upper" and "lower" and other terms indicating orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely to facilitate and simplify the description of the present invention. They are not intended to indicate or imply that the devices or components referred to must have, be constructed, or operate in a specific orientation, and therefore should not be construed as limitations on the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0098] In the description of the present invention, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium, or they can refer to connections between the internal parts of two components. A person of ordinary skill in the art will understand the specific meanings of the above terms in the present invention based on the specific circumstances. In addition, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0099] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A blood product separation and plugging system, characterized in that: It comprises a bottle unscrambling mechanism (2), a turntable (4), a liquid transfer mechanism (5), an automatic capping device (7), a plugging device (8) and a material unloading platform (9), wherein the bottle unscrambling mechanism (2), the liquid transfer mechanism (5), the automatic capping device (7), the plugging device (8) and the material unloading platform (9) are sequentially arranged around the turntable (4); The pipetting mechanism (5) comprises a driving rail (501), a pushing member and a pipette (502), wherein the pushing member is mounted on the driving rail (501), and the pipette (502) is mounted on the pushing member, the driving rail (501) drives the pushing member to move along the length direction of the driving rail (501), and the pushing member drives the pipette (502) to move up and down, and one end of the driving rail (501) is located directly above the turntable (4); The blood product dispensing plug system further includes a base; The blood product hydraulic plugging system further comprises a semi-plugging device (3), and the automatic capping device (7) comprises a cap sorter and a capping track, wherein the end of the capping track is connected to the semi-plugging device (3); The semi-plugging device (3) comprises an axle seat (308), an arc tube (309), a plugging piece (312), an air source mechanism, a driving mechanism and a plugging rubber slide rail (311); The plugging piece (312) is rotatably mounted on the shaft seat (308); the cross section of the plugging piece (312) is a quarter circle; the driving mechanism drives the plugging piece (312) to rotate around the axis of the plugging piece (312); the arc tube (309) is mounted on the outer side of the plugging piece (312); the arc tube (309) and the plugging piece (312) are coaxially arranged; an air hole is opened on the first end face of the arc tube (309); the rubber plug is sucked through the air hole; and the air source mechanism is connected to the arc tube (309); The plugging rubber slide rail (311) is vertically mounted on the shaft seat (308), a track groove for receiving the rubber plug is formed in the plugging rubber slide rail (311), and the lower end of the plugging rubber slide rail (311) is located above the arc tube (309); The arc tube (309) intersects with the lower end of the plugged rubber slide rail (311), and when the arc tube (309) rotates to a first extreme position, a first end surface of the arc tube (309) is flush with the track groove; The side of the turntable (4) is evenly provided with a plurality of grooves, a channel plate (6) is mounted on the base, a circular hole is provided on the channel plate (6), the turntable (4) is coaxially arranged in the circular hole, a feed notch (601) and a discharge notch (602) are respectively provided on the channel plate (6), and the feed notch (601) and the discharge notch (602) are both connected to the circular hole; The bottle unscrambling mechanism (2) comprises a disc (201), a fence (205), a column (202) and a curved rod (203); the channel plate (6) is higher than the disc (201); and the feed notch (601) is located at the edge of the disc (201); The unloading platform (9) is lower than the channel plate (6), and one side of the unloading platform (9) is located directly below the discharge notch (602); The degree of the central angle corresponding to the fence (205) is greater than 120 degrees, the fence (205) is coaxially arranged with the disk (201), and the fence (205) is higher than the disk (201), and one end of the fence (205) is connected to the channel plate (6); The column (202) and the disc (201) are coaxially arranged, and the column (202) and the disc (201) are rotatably connected. The curved rod (203) is installed on the side of the column (202), and a channel is formed between the rod end of the curved rod (203) and the fence (205).

2. A blood product separation plug system according to claim 1, characterized in that: The bottle unscrambling mechanism (2), the turntable (4), the liquid transfer mechanism (5), the automatic capping device (7) and the plugging device (8) are all mounted on the base; A support member is mounted on the base, and the support member is connected to the driving guide rail (501) for supporting the driving guide rail (501).

3. A blood product separation plug system according to claim 2, characterized in that: A liquid storage bottle (13), a gun tip box (14) and a storage box (15) are provided on the base. The liquid storage bottle (13), the gun tip box (14) and the storage box (15) are provided on one side of the driving guide rail (501) along the length direction of the driving guide rail (501). The gun tip box (14) is used to place the gun tip of the pipette (502), and the storage box (15) is used to collect discarded gun tips.

4. A blood product separation plug system according to claim 1, characterized in that: The automatic capping device (7) is used to transport the rubber stopper to the semi-pressing device (3), and the semi-pressing device (3) is used to insert the rubber stopper into the vial on the turntable (4).

5. A blood product separation plug system according to claim 4, characterized in that: A drive shaft is rotatably mounted on the shaft seat (308), the drive shaft is fixedly connected to the plugging piece (312), and the drive shaft and the plugging piece (312) are coaxially arranged; the drive mechanism comprises a motor (306) and a coupling (307), and the output end of the motor (306) is connected to the drive shaft via the coupling (307).

6. A blood product separation plug system according to claim 4, characterized in that: The air source mechanism comprises a hose, an air pump and a one-way throttle valve (301); one end of the hose is connected to the arc-shaped tube (309), and the hose is in communication with the arc-shaped tube (309); the other end of the hose is connected to the one-way throttle valve (301), and the one-way throttle valve (301) is connected to the air pump.

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