A grinding device for the production of valsartan intermediates

Abstract

The present invention relates to the field of pharmaceutical production technology, and discloses a grinding device for the production of valsartan intermediates, comprising a grinding seat, a fixed frame symmetrically installed on the inner side of the upper end of the grinding seat, a grinding box slidably installed on the upper end of the fixed frame, a support frame symmetrically installed on the outer side of the upper end of the grinding seat, a driving shaft connected to the fixed frame rotatably installed between the lower sides of the support frame, a rotating mechanism for driving the grinding box to rotate is provided on the driving shaft, support blocks are slidably installed on both sides of the upper end of the support frame, a driven shaft is installed between the support blocks, a U-shaped frame is connected to the driven shaft, a grinding mechanism is installed on the U-shaped frame, and the driving shaft and the driven shaft are driven and connected through a transmission mechanism. The present invention realizes the periodic reciprocating rotation of the grinding box through the provided rotating mechanism, and at the same time, under the mutual cooperation of the grinding mechanism, the purpose of rapid grinding of the valsartan intermediate inside the grinding box is achieved, and the possibility of generating large agglomerated particle blocks during the grinding process is avoided.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical production, and in particular to a grinding device for producing a valsartan intermediate. Background Art

[0002] Valsartan is an angiotensin II receptor antagonist antihypertensive drug that blocks the angiotensin II type I (AT1) receptor, increases the plasma level of angiotensin II, stimulates the unblocked AT2 receptors, and counteracts the action of the AT1 receptors, thereby achieving the effect of dilating blood vessels and lowering blood pressure.

[0003] The grinding of drugs is to crush the drugs by external force. The traditional method is to grind and crush them by pestle. At present, during the synthesis process of valsartan, solid valsartan intermediates will be produced. The valsartan intermediates need to be ground before subsequent synthesis.

[0004] However, the current traditional grinding method not only has a slow grinding speed, but also does not grind thoroughly, resulting in larger particle blocks after grinding. Therefore, further improvement is needed. Summary of the invention

[0005] The object of the present invention is to provide a grinding device for the production of valsartan intermediates to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A grinding device for producing valsartan intermediates comprises a grinding seat, a fixing frame is symmetrically installed on the inner side of the upper end of the grinding seat, a grinding box is slidably installed on the upper end of the fixing frame, a supporting frame is symmetrically installed on the outer side of the upper end of the grinding seat, a driving shaft connected to the fixing frame is rotatably installed between the lower sides of the supporting frames, a rotating mechanism for driving the grinding box to rotate is arranged on the driving shaft, supporting blocks are slidably installed on both sides of the upper end of the supporting frame, a driven shaft is installed between the supporting blocks, a U-shaped frame is connected to the driven shaft, a grinding mechanism is installed on the U-shaped frame, and the driving shaft and the driven shaft are driven and connected by a transmission mechanism.

[0008] As an improved solution of the present invention: a grinding plate is installed inside the grinding box, a plurality of grinding holes are arranged on the grinding plate, a discharge hole is installed at the bottom of the grinding box, and a collecting trough that cooperates with the discharge hole is installed on the grinding seat.

[0009] As an improved solution of the present invention: a circle of sliding ring groove is arranged at the bottom of the grinding box, and a trapezoidal ring block arranged on the top of the fixing frame is slidably installed inside the sliding ring groove, and the cross-section of the sliding ring groove is a dovetail groove structure.

[0010] As an improved solution of the present invention: the rotating mechanism includes an upper half gear and a lower half gear fixed on the driving shaft, a fixed gear ring alternately meshing with the upper half gear and the lower half gear is installed at the bottom of the grinding box, and one end of the driving shaft is connected to the output end of the grinding motor installed on the support frame.

[0011] As an improved solution of the present invention: the transmission mechanism includes a driving pulley fixed on the driving shaft, the outer side of the driving pulley is meshed with a driven pulley rotatably arranged on the support frame through a belt, the driven pulley is coaxially fixedly connected with a driving gear, the outer side of the driving gear is meshed with an intermediate gear, the outer side of the intermediate gear is meshed with a driven gear fixed on the driven shaft, an upper connecting rod is coaxially hinged between the driven gear and the intermediate gear, and a lower connecting rod is coaxially connected between the intermediate gear and the driving gear.

[0012] As an improved solution of the present invention: the support frame is provided with a support groove that cooperates with the support block, and a support spring is connected between the bottom side of the support groove and the support block.

[0013] As an improved solution of the present invention: the grinding mechanism includes a grinding cylinder fixed at the bottom of the U-shaped frame, an upper rotating block is rotatably installed on the upper side of the grinding cylinder, the lower side of the upper rotating block contacts with a lower lifting block arranged on the lower side of the grinding cylinder through a wedge surface, a grinding column is installed at the bottom of the lower lifting block, the grinding column passes through the grinding cylinder and is connected to a grinding disk, a number of grinding contacts are arranged at the bottom of the grinding disk, and the grinding mechanism also includes a limit assembly for limiting the movement direction of the lower lifting block.

[0014] As an improved solution of the present invention: the limit assembly includes a limit bar fixed on the inner wall of the grinding cylinder, the limit bar slides in the limit groove arranged on the outer wall of the lower lifting block, and a limit spring is sleeved on the outer side of the grinding column between the grinding cylinder and the grinding disk.

[0015] As an improved solution of the present invention: a rotating shaft is installed on the upper end of the upper rotating block, a lower transmission gear is installed on the upper end of the rotating shaft, an upper transmission gear is meshed on the upper end of the lower transmission gear, and the upper transmission gear is fixed on the driven shaft.

[0016] As an improved solution of the present invention: an adjusting cylinder is symmetrically installed on the top of the support frame, and the adjusting column of the adjusting cylinder is connected to the U-shaped frame.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The grinding device for producing valsartan intermediates has a reasonable structure and a novel design. The periodic reciprocating rotational motion of the grinding box is realized by the arranged rotating mechanism. Meanwhile, with the mutual cooperation of the grinding mechanisms, the purpose of rapid grinding of the valsartan intermediates inside the grinding box is achieved, and the possibility of generating large agglomerated particle blocks during the grinding process is avoided. The device has strong practicality and high reliability. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall front view structure of the present invention;

[0020] Figure 2 It is a schematic diagram of the overall bottom-up structure of the present invention;

[0021] Figure 3 It is a side structural schematic diagram of the transmission mechanism in the present invention;

[0022] Figure 4 It is a front view structural schematic diagram of the transmission mechanism in the present invention;

[0023] Figure 5 It is a partial cross-sectional structural schematic diagram of the present invention;

[0024] Figure 6 for Figure 5 Schematic diagram of the locally enlarged structure of A in the middle.

[0025] In the figure: 1. grinding seat; 2. support frame; 3. adjusting cylinder; 4. adjusting column; 5. driven shaft; 6. U-shaped frame; 7. grinding cylinder; 8. grinding box; 9. fixed frame; 10. driving shaft; 11. collecting tank; 12. grinding motor; 13. sliding ring groove; 14. fixed gear ring; 15. discharge hole; 16. upper half gear; 17. lower half gear; 18. supporting groove; 19. supporting block; 20. supporting spring; 21. driven gear; 22. upper connecting rod; 23, intermediate gear; 24, driving gear; 25, driving pulley; 26, lower connecting rod; 27, driven pulley; 28, belt; 29, upper transmission gear; 30, lower transmission gear; 31, grinding disc; 32, grinding contact; 33, grinding plate; 34, grinding hole; 35, rotating shaft; 36, upper rotating block; 37, lower lifting block; 38, limiting groove; 39, limiting strip; 40, grinding column; 41, limiting spring; 42, wedge surface. DETAILED DESCRIPTION

[0026] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0027] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and the like are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first", "second", and the like may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0028] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal connection of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood by specific circumstances.

[0029] The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0030] Example 1

[0031] See also Figures 1 to 6 In an embodiment of the present invention, a grinding device for producing valsartan intermediates comprises a grinding seat 1, a fixing frame 9 is symmetrically installed on the inner side of the upper end of the grinding seat 1, a grinding box 8 is slidably installed on the upper end of the fixing frame 9, a support frame 2 is symmetrically installed on the outer side of the upper end of the grinding seat 1, and the support frame 2 is an inverted U-shaped structure. A driving shaft 10 connected to the fixing frame 9 is rotatably installed between the lower sides of the support frame 2, and a rotating mechanism for driving the grinding box 8 to rotate is provided on the driving shaft 10, so that the grinding box 8 reciprocates clockwise and counterclockwise. Support blocks 19 are slidably installed on both sides of the upper end of the support frame 2, and a driven shaft 5 is installed between the support blocks 19. A U-shaped frame 6 is connected to the driven shaft 5, and a grinding mechanism is installed on the U-shaped frame 6 for fully grinding the pharmaceutical intermediate located inside the grinding box 8. The driving shaft 10 and the driven shaft 5 are driven and connected by a transmission mechanism, thereby ensuring the power matching input of the grinding mechanism and the rotating mechanism.

[0032] In one case of this embodiment, a grinding plate 33 is installed inside the grinding box 8, and a plurality of grinding holes 34 are arranged on the grinding plate 33. A discharge hole 15 is installed at the bottom of the grinding box 8, and a collecting tank 11 that cooperates with the discharge hole 15 is installed on the grinding seat 1. The pharmaceutical intermediate is placed on the grinding plate 33, and after the grinding is completed, the ground material enters the discharge hole 15 through the grinding hole 34, and then is introduced into the collecting tank 11 for collection.

[0033] In order to further ensure the stability of the grinding box 8 when rotating along the top of the fixed frame 9, a circle of sliding ring grooves 13 is provided at the bottom of the grinding box 8, and a trapezoidal ring block arranged on the top of the fixed frame 9 is slidably installed inside the sliding ring groove 13, and the cross-section of the sliding ring groove 13 is a dovetail groove structure.

[0034] In the preferred embodiment of this embodiment, the rotating mechanism includes an upper half gear 16 and a lower half gear 17 fixed on the driving shaft 10, a fixed gear ring 14 alternately meshing with the upper half gear 16 and the lower half gear 17 is installed at the bottom of the grinding box 8, and one end of the driving shaft 10 is connected to the output end of the grinding motor 12 installed on the support frame 2. During operation, the grinding motor 12 is started to rotate the driving shaft 10, and then the upper half gear 16 and the lower half gear 17 alternately mesh with the fixed gear ring 14 at the bottom of the grinding box 8, and finally the grinding box 8 reciprocates clockwise and counterclockwise.

[0035] In one case of this embodiment, the transmission mechanism includes a driving pulley 25 fixed on the driving shaft 10, and the outer side of the driving pulley 25 is meshed with a driven pulley 27 rotatably arranged on the support frame 2 through a belt 28, and the driven pulley 27 is coaxially fixedly connected with a driving gear 24, and the outer side of the driving gear 24 is meshed with an intermediate gear 23, and the outer side of the intermediate gear 23 is meshed with a driven gear 21 fixed on the driven shaft 5, and an upper connecting rod 22 is coaxially hinged between the driven gear 21 and the intermediate gear 23, and a lower connecting rod 26 is coaxially connected between the intermediate gear 23 and the driving gear 24. Through the mutual cooperation between the above-mentioned several pulleys and gears, the torque on the driving shaft 10 can be transmitted to the driven shaft 5, and finally the grinding mechanism is driven to work. And under the limiting action of the upper connecting rod 22 and the lower connecting rod 26, when the position between the driving shaft 10 and the driven shaft 5 changes, it will not affect the normal transmission of torque between them, which further improves the reliability of the transmission mechanism.

[0036] In the preferred case of this embodiment, the grinding mechanism includes a grinding cylinder 7 fixed at the bottom of the U-shaped frame 6, and an upper rotating block 36 is rotatably installed on the upper side of the grinding cylinder 7. The lower side of the upper rotating block 36 contacts a lower lifting block 37 arranged on the lower side of the grinding cylinder 7 through a wedge surface 42. A grinding column 40 is installed at the bottom of the lower lifting block 37. The grinding column 40 passes through the grinding cylinder 7 and is connected to a grinding disk 31. A plurality of grinding contacts 32 are arranged at the bottom of the grinding disk 31. The grinding mechanism also includes a limit assembly for limiting the movement direction of the lower lifting block 37.

[0037] Among them, the limiting assembly includes a limiting bar 39 fixed on the inner wall of the grinding cylinder 7, the limiting bar 39 slides in the limiting groove 38 arranged on the outer wall of the lower lifting block 37, and a limiting spring 41 is sleeved on the outer side of the grinding column 40 between the grinding cylinder 7 and the grinding disc 31.

[0038] In addition, a rotating shaft 35 is installed on the upper end of the upper rotating block 36 , a lower transmission gear 30 is installed on the upper end of the rotating shaft 35 , an upper transmission gear 29 is meshed with the upper end of the lower transmission gear 30 , and the upper transmission gear 29 is fixed on the driven shaft 5 .

[0039] During the rotation of the driven shaft 5, the upper transmission gear 29 and the lower transmission gear 30 cooperate to make the rotating shaft 35 drive the upper rotating block 36 to rotate. Then, with the cooperation of the wedge surface 42, the lower lifting block 37 will drive the grinding disc 31 to move up and down under the action of the limit bar 39, the limit groove 38 and the limit spring 41, thereby performing extrusion grinding on the pharmaceutical intermediate located on the upper side of the grinding plate 33, and finally cooperating with the rotating grinding box 8 to ensure a more sufficient and thorough grinding effect.

[0040] In this embodiment, an adjusting cylinder 3 is symmetrically installed on the top of the support frame 2, and the adjusting column 4 of the adjusting cylinder 3 is connected to the U-shaped frame 6. Through the cooperation of the above structure, the initial grinding distance between the grinding disc 31 and the grinding plate 33 can be adjusted, further improving the reliability of grinding.

[0041] Example 2

[0042] In another embodiment of the present invention, this embodiment differs from the above-mentioned embodiment in that a support groove 18 cooperating with a support block 19 is provided on the support frame 2, and a support spring 20 is connected between the bottom side of the support groove 18 and the support block 19, so that when the driven shaft 5 changes its upper and lower positions, a large range of shaking will not occur, thereby further improving the reliability of the device.

[0043] The working principle of the present invention is: first, the intermediate to be ground is placed on the grinding plate 33, and then the position between the grinding disc 31 and the grinding plate 33 is adjusted by the adjusting cylinder 3, and then the grinding motor 12 is started, so that the driving shaft 10 drives the rotating mechanism to work on the one hand, ensuring that the grinding box 8 rotates back and forth, and on the other hand, with the cooperation of the transmission mechanism, the driven shaft 5 drives the grinding mechanism to work, so that the grinding disc 31 performs up and down extrusion grinding, and finally the intermediate is fully ground. The whole operation process is quick and convenient, and it is worthy of popularization and use.

[0044] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A grinding device for the production of valsartan intermediates, comprising a grinding seat (1), characterized in that: A fixing frame (9) is symmetrically mounted on the inner side of the upper end of the grinding seat (1), a grinding box (8) is slidably mounted on the upper end of the fixing frame (9), a supporting frame (2) is symmetrically mounted on the outer side of the upper end of the grinding seat (1), a driving shaft (10) connected to the fixing frame (9) is rotatably mounted between the lower sides of the supporting frame (2), a rotating mechanism for driving the grinding box (8) to rotate is arranged on the driving shaft (10), supporting blocks (19) are slidably mounted on both sides of the upper end of the supporting frame (2), a driven shaft (5) is mounted between the supporting blocks (19), a U-shaped frame (6) is connected to the driven shaft (5), a grinding mechanism is mounted on the U-shaped frame (6), and the driving shaft (10) and the driven shaft (5) are connected by a transmission mechanism; The rotating mechanism comprises an upper half gear (16) and a lower half gear (17) fixed on the driving shaft (10); a fixed gear ring (14) alternately meshing with the upper half gear (16) and the lower half gear (17) is installed at the bottom of the grinding box (8); one end of the driving shaft (10) is connected to the output end of a grinding motor (12) installed on a support frame (2); The grinding mechanism comprises a grinding cylinder (7) fixed at the bottom of the U-shaped frame (6); an upper rotating block (36) is rotatably mounted on the upper side of the grinding cylinder (7); the lower side of the upper rotating block (36) contacts a lower lifting block (37) arranged on the lower side of the grinding cylinder (7) through a wedge surface (42); a grinding column (40) is mounted on the bottom of the lower lifting block (37); the grinding column (40) passes through the grinding cylinder (7) and is connected to a grinding disc (31); a plurality of grinding contacts (32) are arranged on the bottom of the grinding disc (31); the grinding mechanism also comprises a limit assembly for limiting the movement direction of the lower lifting block (37); The limiting assembly comprises a limiting bar (39) fixed on the inner wall of the grinding cylinder (7), the limiting bar (39) slides in a limiting groove (38) arranged on the outer wall of the lower lifting block (37), and a limiting spring (41) is sleeved on the outer side of the grinding column (40) between the grinding cylinder (7) and the grinding disc (31).

2. A grinding device for the production of valsartan intermediates according to claim 1, characterized in that: A grinding plate (33) is installed inside the grinding box (8), and a plurality of grinding holes (34) are arranged on the grinding plate (33). A discharge hole (15) is installed at the bottom of the grinding box (8), and a collecting trough (11) that cooperates with the discharge hole (15) is installed on the grinding seat (1).

3. A grinding device for the production of valsartan intermediates according to claim 2, characterized in that: A circle of sliding ring groove (13) is arranged at the bottom of the grinding box (8), and a trapezoidal ring block arranged on the top of the fixing frame (9) is slidably installed inside the sliding ring groove (13), and the cross section of the sliding ring groove (13) is a dovetail groove structure.

4. A grinding device for producing a valsartan intermediate according to claim 1, characterized in that: The transmission mechanism comprises a driving pulley (25) fixed on a driving shaft (10), the outer side of the driving pulley (25) is meshed with a driven pulley (27) rotatably arranged on a support frame (2) through a belt (28), a driving gear (24) is coaxially fixedly connected to the driven pulley (27), an intermediate gear (23) is meshed on the outer side of the driving gear (24), a driven gear (21) fixed on the driven shaft (5) is meshed on the outer side of the intermediate gear (23), an upper connecting rod (22) is coaxially hinged between the driven gear (21) and the intermediate gear (23), and a lower connecting rod (26) is coaxially intersected between the intermediate gear (23) and the driving gear (24).

5. A grinding device for producing a valsartan intermediate according to claim 4, characterized in that: The support frame (2) is provided with a support groove (18) that cooperates with the support block (19), and a support spring (20) is connected between the bottom side of the support groove (18) and the support block (19).

6. A grinding device for producing a valsartan intermediate according to claim 1, characterized in that: The upper end of the upper rotating block (36) is provided with a rotating shaft (35), the upper end of the rotating shaft (35) is provided with a lower transmission gear (30), the upper end of the lower transmission gear (30) is meshed with an upper transmission gear (29), and the upper transmission gear (29) is fixed on the driven shaft (5).

7. A grinding device for producing a valsartan intermediate according to claim 6, characterized in that: An adjusting cylinder (3) is symmetrically mounted on the top of the support frame (2), and an adjusting column (4) of the adjusting cylinder (3) is connected to the U-shaped frame (6).

Images