Sample image scanning device and method

Abstract

The application discloses a sample image scanning device and method, the device comprises a transport mechanism, a scanning mechanism and a controller, the first surface of the sample slide is provided with a sample area, the controller is used for: controlling the transport mechanism to transport the sample slide to the slide placement area; controlling the scanning mechanism to perform a first scanning operation on the sample slide to determine whether the first surface is directed to the objective assembly of the scanning mechanism and whether the sample area is coated with a sample to be measured; when it is determined that the first surface is not directed to the objective assembly, a rotating operation is performed on the sample slide, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide again; when it is determined that the first surface of the sample slide is directed to the objective assembly and the sample area is coated with the sample to be measured, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be measured, and the application can accurately obtain the coating condition of the sample to be measured, and the accuracy, definition and efficiency of the scanning on the sample slide are improved.

Description

Technical Field

[0001] This application relates to the field of medical devices, and more particularly to a sample image scanning device and method. Background Technology

[0002] Currently, in scenarios involving the use of test samples for biological health analysis, the sample needs to be placed on the labeled side of the slide during slide preparation. Scanning the slide then requires identifying the label to determine if the slide is properly supporting the sample. However, during slide preparation, operational errors may occur, resulting in the sample being placed on an unlabeled surface or even not being properly coated on the slide, leading to inaccurate scanning during image acquisition. Summary of the Invention

[0003] This application provides a sample image scanning device and method, which aims to solve the problem that existing sample image scanning devices cannot accurately scan sample slides when scanning them because it is difficult to determine whether the sample to be tested is coated on the sample slide and the specific coating location on the sample slide.

[0004] In a first aspect, this application provides a sample image scanning device, which includes:

[0005] A transfer mechanism for transferring sample slides, the sample slides having a first surface and a second surface disposed opposite to the first surface, the first surface having a sample area for coating the sample to be tested;

[0006] The scanning mechanism is a sample image scanning device with a slide placement area. The scanning mechanism is used to scan the sample slide located in the slide placement area.

[0007] The controller, electrically connected to the transfer mechanism and the scanning mechanism, is used for:

[0008] The control transfer mechanism transfers the sample slides to the slide placement area;

[0009] The scanning mechanism is controlled to perform a first scan operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested.

[0010] When it is determined that the first surface of the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested.

[0011] When it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested.

[0012] In some embodiments, after controlling the scanning mechanism to perform the first scan operation on the rotated sample slide, the controller is further configured to:

[0013] When it is determined that the first surface of the rotated sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested.

[0014] When it is determined that the first surface of the sample slide after rotation is still not facing the objective lens assembly of the scanning mechanism, and / or when it is determined that the sample area is not coated with the sample to be tested, the sample slide is judged to be an abnormal slide.

[0015] In some embodiments, the controller controls the scanning mechanism to perform a first scanning operation on the sample slide, including:

[0016] The scanning mechanism is controlled to scan at least one scanning position on the surface of the sample slide facing the objective lens assembly to obtain a scanning image corresponding to the scanning position;

[0017] Perform detection operations on the scanned image;

[0018] When the number of scanned images obtained through the detection operation exceeds a first quantity threshold, it is determined that the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested.

[0019] In some implementations, the controller performs a detection operation on the scanned image, including:

[0020] Determine the scanning distance corresponding to the scanned image;

[0021] Determine whether the scanned image matches the preset cell image model;

[0022] When it is determined that the scanned image matches the preset cell image model and the scanning distance is within the preset distance range, the scanned image is determined to have passed the detection operation.

[0023] In some implementations, after the controller performs a detection operation on the scanned image, it further includes:

[0024] When the number of scanned images obtained through the detection operation is less than or equal to a first number threshold, the scanning mechanism is controlled to scan at least one additional scanning position on the surface of the sample slide facing the objective lens assembly, wherein the additional scanning position matches the sample area.

[0025] Detection is performed based on the additional scan image obtained by scanning the additional scan locations;

[0026] When the sum of the number of scanned images obtained through the detection operation and the number of additional scanned images is greater than a second quantity threshold, it is determined that the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, wherein the second quantity threshold is greater than or equal to the first quantity threshold.

[0027] In some embodiments, the controller controls the scanning mechanism to perform a first scanning operation on the sample slide, and further includes:

[0028] The scanning mechanism is controlled to scan at least one of the sample area and the marking area outside the sample area to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism.

[0029] The scanning mechanism is controlled to scan the sample area to determine whether the sample area is coated with the sample to be tested.

[0030] In some implementations, the controller is also used for:

[0031] When a sample slide is determined to be abnormal, the control transfer mechanism will transfer the sample slide to the recycling mechanism;

[0032] The control and recycling mechanism receives sample slides and performs preset recycling operations on the sample slides.

[0033] In some embodiments, the sample image scanning device further includes a first rotation mechanism, wherein the controller rotates the sample slide, including:

[0034] The first rotation mechanism is controlled to perform a first rotation operation on the sample glass slide located in the glass slide placement area.

[0035] In some embodiments, the sample image scanning device further includes a second rotation mechanism, wherein the controller rotates the sample slide, including:

[0036] The control transfer mechanism transports the sample slides away from the slide placement area;

[0037] The second rotating mechanism is controlled to receive the sample slide and perform a second rotation operation on the sample slide;

[0038] The control transfer mechanism transfers the rotated sample slide to the slide placement area.

[0039] In some implementations, the controller performs a preset rotation operation on the sample slide, including:

[0040] The control transfer mechanism performs a preset third rotation operation on the sample slide.

[0041] In some embodiments, the first rotating mechanism includes a support component for carrying a sample slide located in the slide placement area. When the controller controls the first rotating mechanism to perform a preset first rotation operation on the sample slide located in the slide placement area, it includes:

[0042] The carrier component is controlled to rotate, thereby rotating the sample slide so that the second surface of the sample slide faces the scanning mechanism.

[0043] In some embodiments, the sample image scanning device further includes an identification mechanism for identifying sample information on the sample slide.

[0044] Secondly, this application also provides a sample image scanning method, applied to the sample image scanning device disclosed in any embodiment of this application, the method comprising:

[0045] The control transfer mechanism transfers the sample slides to the slide placement area;

[0046] The scanning mechanism is controlled to perform a first scan operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested.

[0047] When it is determined that the first surface of the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested.

[0048] When it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested.

[0049] This application provides a sample image scanning device and a sample image scanning method. The sample image scanning device includes a transfer mechanism, a scanning mechanism, and a controller. The device also includes a slide placement area. The transfer mechanism is used to transfer sample slides, each having a first surface and a second surface opposite to the first surface. The first surface has a sample area for coating the sample to be tested. The scanning mechanism scans the sample slide located in the slide placement area. The controller is electrically connected to the transfer mechanism and the scanning mechanism. The controller is used to: control the transfer mechanism to transfer the sample slide to the slide placement area; control the scanning mechanism to perform a first scan operation on the sample slide to determine whether the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; and when the first surface of the sample slide is determined to be facing the objective lens assembly of the scanning mechanism, the controller performs a first scan operation to determine whether the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested. When the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; when it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested, thereby solving the problem of difficulty in determining the coating status of the sample to be tested on the sample slide, wherein the coating status is, for example, whether the sample to be tested is coated on the sample slide and the specific coating position of the sample slide, etc. Therefore, this application improves the accuracy, clarity and efficiency of scanning the sample slide.

[0050] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit the disclosure of the embodiments of this application. Attached Figure Description

[0051] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0052] Figure 1 A block diagram of a sample image scanning device provided in this application embodiment;

[0053] Figure 2 This is a schematic diagram of the structure of a sample image scanning device provided in an embodiment of this application;

[0054] Figure 3A schematic diagram of the structure of the first rotating mechanism and the second rotating mechanism of a sample image scanning device provided in this application embodiment;

[0055] Figure 4 A schematic diagram and an exploded view of the structure of the second rotating mechanism of a sample image scanning device provided in this application embodiment;

[0056] Figure 5 A logic diagram for the sample image scanning device provided in this application to perform a first scanning operation on a sample slide and / or a first scanning operation on a rotated sample slide;

[0057] Figure 6 This is a schematic flowchart of a sample image scanning method provided in an embodiment of this application.

[0058] Figure label:

[0059] 100. Sample image scanning device; 10. Transfer mechanism; 20. Scanning mechanism; 21. Objective lens assembly; 30. Controller; 31. First rotating mechanism; 311. First assembly assembly; 32. Second rotating mechanism; 321. First side piece; 322. Second side piece; 323. Connecting base piece; 324. Rotation drive piece; 325. Second assembly slot; 33. Third rotating mechanism; 331. Third assembly assembly; 40. Recovery mechanism; 50. Identification mechanism; 200. Sample slide. Detailed Implementation

[0060] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0061] Currently, in scenarios involving the use of test samples for biological health analysis, the sample needs to be placed on the labeled side of the slide during slide preparation. Scanning the slide then requires identifying the label to determine if the slide is properly supporting the sample. However, during slide preparation, operational errors may occur, resulting in the sample being placed on an unlabeled surface or even not being properly coated on the slide, leading to inaccurate scanning during image acquisition.

[0062] Based on this, embodiments of this application provide a sample image scanning device and method. Some embodiments of this application will be described in detail below with reference to the accompanying drawings. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0063] Please see Figures 1 to 2 , Figure 1 This is a block diagram of the module structure of a sample image scanning device 100 provided in an embodiment of this application. Figure 2 This is a schematic diagram of the structure of a sample image scanning device 100 provided in an embodiment of this application.

[0064] like Figures 1 to 2 As shown, the sample image scanning device 100 is used to perform scanning operations on the sample slide 200, and the sample image scanning device 100 includes a transfer mechanism 10, a scanning mechanism 20 and a controller 30. The sample slide 200 has a first surface and a second surface disposed opposite to the first surface, and the first surface is provided with a sample area for coating the sample to be tested.

[0065] Specifically, the sample image scanning device 100 is pre-set with at least one slide placement area, and the transfer mechanism 10 is used to transfer the sample slide 200, for example, to transfer the sample slide 200 to be tested to the slide placement area. The scanning mechanism 20 is set corresponding to the slide placement area and is used to perform image scanning operation on the sample slide 200 located in the slide placement area. The controller 30 is electrically connected to the transfer mechanism 10 and the scanning mechanism 20, and is configured to: control the transfer mechanism 10 to transfer the sample slide 200 to the slide placement area; control the scanning mechanism 20 to perform a first scan operation on the sample slide 200 to determine whether the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and whether the sample area is coated with the sample to be tested; when it is determined that the first surface of the sample slide 200 does not face the objective lens assembly 21 of the scanning mechanism 20, rotate the sample slide 200, and control the scanning mechanism 20 to perform the first scan operation on the rotated sample slide 200 to determine whether the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and whether the sample area is coated with the sample to be tested; when it is determined that the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and the sample area is coated with the sample to be tested, control the scanning mechanism 20 to perform a second scan operation on the sample area to obtain image information of the sample to be tested.

[0066] It should be noted that when the controller 30 controls the scanning mechanism 20 to perform the first scanning operation on the sample slide 200, one of the first surface and the second surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20. The first scanning result obtained by the first scanning operation includes the sample coating condition on the side of the sample slide 200 facing the objective lens assembly 21. The sample coating condition includes at least whether the side of the sample slide 200 facing the objective lens assembly 21 is coated with the sample to be tested.

[0067] The slide placement area can be a pre-defined spatial area in the sample image scanning device 100. The sample image scanning device 100 can also be pre-defined with a carrier component for carrying the sample slide 200 to be tested, and the carrier component forms the slide placement area.

[0068] It should be understood that the sample area is disposed on the first surface of the sample slide 200. For example, the sample area is specifically disposed on the first surface of the sample slide 200 and is used to coat the sample to be tested. The first surface of the sample slide also includes a frosted area of ​​the slide and / or a screen-printed area of ​​the slide, and / or a QR code, and / or a barcode, etc., disposed outside the sample area. It should be noted that when the scanning mechanism 20 scans the sample slide 200, the controller can determine the orientation of the first surface through at least one of the sample area, the frosted area of ​​the slide, the screen-printed area of ​​the slide, the QR code, and the barcode.

[0069] It should also be understood that the first scan result obtained when the scanning mechanism 20 scans the sample slide 200 includes at least whether the side of the sample slide 200 facing the objective lens assembly 21 is coated with the sample to be tested. Exemplarily, the scanning mechanism 20 includes at least an objective lens assembly 21 disposed corresponding to the slide placement area, the objective lens assembly 21 being positioned relative to the slide placement area in a preset scanning direction, and the scanning mechanism 20 scans the sample slide 200 located in the slide placement area via the objective lens assembly 21.

[0070] It should be noted that the transfer mechanism moves the horizontally positioned sample slide 200 to the slide placement area, that is, the sample slide 200 is placed horizontally in the slide placement area, and the scanning mechanism 20 scans the horizontally placed sample slide 200. Therefore, the first scan result includes at least whether the side of the sample slide 200 facing the objective lens assembly 21 is coated with the sample to be tested.

[0071] Specifically, the scanning mechanism 20 includes an objective lens assembly 21, a scanning platform, and a light source assembly. The scanning platform is used to place the sample slide 200, and the objective lens assembly 21 performs image scanning operations on the sample slide transferred to the scanning platform. The light source assembly is used to provide illumination to the sample slide during the scanning operation of the objective lens assembly 21.

[0072] In some implementations, the first scan result includes not only whether the side of the sample slide 200 facing the objective lens assembly 21 is coated with the sample to be tested, but also whether the side of the sample slide 200 facing away from the objective lens assembly 21 is coated with the sample to be tested.

[0073] It is easy to understand that, given that the sample slide 200 is coated with the sample to be tested, when the side of the sample slide 200 facing the objective lens assembly 21 is not coated with the sample to be tested, it can be determined that the side of the sample slide 200 facing away from the objective lens assembly 21 is coated with the sample to be tested.

[0074] Furthermore, when the scanning mechanism 20 scans along the scanning direction, it can also scan through the sample slide 200 to the second surface of the sample slide 200 facing away from the scanning mechanism 200, so as to determine whether the second target area of ​​the second surface of the sample slide 200 is coated with the sample to be tested. Therefore, the first scanning result also includes whether the second target area of ​​the second surface of the sample slide 200 is coated with the sample to be tested.

[0075] In some implementations, when it is determined that the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and the sample area is coated with the sample to be tested, the controller 30 controls the scanning mechanism 20 to perform a second scanning operation on the sample area. Specifically, the controller scans the first surface of the sample slide 200 based on the first scanning result obtained from the first scanning operation on the sample slide 200 to obtain image information of the sample slide 200.

[0076] It should be understood that the first scanning operation performed by the scanning mechanism 20 on the sample slide 200 to obtain the first scanning result can not only determine the coating condition of the sample to be tested on the sample slide 200 based on the first scanning result, but also perform a further third scanning operation based on the sample slide 200 information obtained from the first scanning result to obtain an accurate and comprehensive sample image, so as to use the sample image for normal analysis and testing. The sample slide 200 information includes, for example, the optimal focal position of the scanning component, the precise position of the midpoint of the first surface of the sample slide 200, the unevenness of the first surface of the sample slide 200, the specific coating position of the sample to be tested, and the concentration information of particles in the sample to be tested, etc.

[0077] It should be noted that scanning the first surface of the sample slide 200 includes, for example, performing a corresponding scanning operation according to the type of sample slide, so that medical personnel can analyze the scanned sample images.

[0078] Specifically, if the sample slide is a blood smear slide, the controller 30 controls the scanning mechanism 20 to use a low-power objective to locate the corresponding positions of nucleated cells, platelet aggregation, etc. in the blood sample, and then uses a high-power objective to scan each position point at high magnification based on the location. If the sample slide is a microecological slide, the controller 30 controls the scanning mechanism 20 to directly use a high-power objective to locate and photograph positive cells in the sample to be tested on the microecological slide. If the sample slide is a pathological liquid-based slide, the controller 30 controls the use of an objective of a specified magnification to scan the entire pathological area in the sample area to obtain multiple sub-images, and uses a stitching algorithm to stitch the multiple sub-images together to generate a complete digital image of the pathological area.

[0079] By first controlling the transfer mechanism 10 to transfer the sample slide 200 to the slide placement area, and then controlling the scanning mechanism 20 to perform a first scanning operation on the sample slide 200 to obtain a first scanning result including whether the first surface of the sample slide 200 is coated with the sample to be tested, it is possible to determine whether the sample to be tested is coated on the sample slide 200 and the specific coating position of the sample slide 200, so as to accurately scan the sample slide 200, thereby improving the accuracy, clarity and efficiency of scanning the sample slide 200.

[0080] In some embodiments, the first scan result obtained by the scanning mechanism 20 in the first scan operation on the sample slide 200 also includes an image corresponding to the first surface. When it is determined that the sample area on the first surface of the sample slide 200 is coated with the sample to be tested, the image corresponding to the first surface can be used as a sample image for normal analysis and testing. Therefore, when the sample area on the first surface is coated with the sample to be tested, only the first scan operation on the sample slide 200 is needed to complete the acquisition of the coating condition of the sample to be tested and the acquisition of the sample image of the sample to be tested, thereby improving the efficiency of sample image scanning.

[0081] In some embodiments, after controlling the scanning mechanism 20 to perform the first scanning operation on the rotated sample slide 200, the controller 30 is further configured to:

[0082] When it is determined that the first surface of the rotated sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and the sample area is coated with the sample to be tested, the scanning mechanism 20 is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested.

[0083] When it is determined that the first surface of the rotated sample slide 200 is still not facing the objective lens assembly 21 of the scanning mechanism 20, and / or when it is determined that the sample area is not coated with the sample to be tested, the sample slide 200 is judged to be an abnormal slide.

[0084] Specifically, the controller 30 acquires the first scan result of the scanning mechanism 20 and determines whether the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and whether the sample area is coated with the sample to be tested. When it is determined that the first surface of the sample slide 200 does not face the objective lens assembly 21 of the scanning mechanism 20, the controller 30 performs a preset rotation operation on the sample slide 200, and then controls the scanning mechanism 20 to perform the first scan operation on the rotated sample slide 200 again to determine whether the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and whether the sample area is coated with the sample to be tested. When it is determined that the first surface of the rotated sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and the sample area is coated with the sample to be tested, the controller controls the scanning mechanism 20 to perform a second scan operation on the sample area to obtain the image information of the sample to be tested. If it is determined that the first surface of the rotated sample slide 200 is still not facing the objective lens assembly 21 of the scanning mechanism 20, and / or the sample area is not coated with the sample to be tested, the sample slide is judged to be an abnormal slide.

[0085] It should be noted that after determining that the sample slide 200 is an abnormal slide, the controller 30 is also used to control the scanning mechanism 20 to pause scanning of the abnormal slide and control the transfer device to transfer the abnormal slide to the preset abnormal recovery area.

[0086] Furthermore, after performing the first scan operation on the rotated sample slide 200, the coating condition of the sample to be tested on the sample slide 200 can be determined based on the first scan result obtained from the first scan operation. Further scan operations can also be performed based on the sample slide 200 information obtained from the first scan result to obtain an accurate and comprehensive sample image for normal analysis and testing. The sample slide 200 information includes, for example, the optimal focal position of the scanning component, the precise position of the midpoint of the second surface of the sample slide 200, the unevenness of the second surface of the sample slide 200, the specific coating position of the sample to be tested, and the concentration information of particles in the sample to be tested, etc.

[0087] It should be noted that further scanning operations based on the sample slide 200 information obtained from the first scan result may include, for example, performing corresponding scanning operations according to the type of sample slide, so that medical personnel can analyze the scanned sample images.

[0088] Specifically, if the sample slide is a blood smear slide, the controller 30 controls the scanning mechanism 20 to use a low-power objective to locate the corresponding positions of nucleated cells, platelet aggregation, etc. in the blood sample, and then uses a high-power objective to scan each position point at a high magnification. If the sample slide is a microecological slide, the controller 30 controls the scanning mechanism 20 to directly use a high-power objective to locate and photograph positive cells in the sample to be tested on the microecological slide. If the sample slide is a pathological liquid-based slide, the controller 30 controls the use of an objective of a specified magnification to scan the entire pathological area in the second target area to obtain multiple sub-images, and uses a stitching algorithm to stitch the multiple sub-images together to generate a complete digital image of the pathological area.

[0089] Specifically, the sample image scanning device 100 provided in this application is equipped with a matching rotating mechanism to rotate the sample slide 200. The rotating mechanism is electrically connected to the controller 30, and the controller 30 performs a preset rotation operation on the sample slide 200 so that the second surface of the sample slide 200 faces the scanning mechanism 20. This is specifically achieved by controlling the rotating mechanism. It should be understood that the rotating mechanism can directly rotate the sample slide 200 located in the slide placement area, or it can first move the sample slide 200 to another area spaced apart from the slide placement area, and then rotate the sample slide 200.

[0090] like Figure 1 As shown, in some embodiments, the sample image scanning device 100 further includes a first rotation mechanism 31 disposed corresponding to the slide placement area. When the controller 30 performs a preset rotation operation on the sample slide 200 so that the second surface of the sample slide 200 faces the scanning mechanism 20, it includes controlling the first rotation mechanism 31 to perform a preset first rotation operation on the sample slide 200 located in the slide placement area.

[0091] Specifically, the first rotating mechanism 31 is configured corresponding to the slide placement area, and includes a first assembly component 311. The first assembly component 311 is configured corresponding to the slide placement area and is used to assemble the sample slide 200 located in the slide placement area. For example, when the controller 30 controls the first rotating mechanism 31 to perform a preset first rotation operation on the sample slide 200 located in the slide placement area, it specifically includes controlling the first assembly component 311 to rotate relative to the scanning mechanism 20, thereby driving the sample slide 200 assembled on the first assembly component 311 to rotate. It should be noted that the first assembly component 311 and the aforementioned carrier component can be the same component.

[0092] Before performing the first scanning operation on the sample slide 200, the controller 30 first controls the transfer mechanism 10 to move the slide to the first assembly position so that the sample slide 200 is assembled on the first assembly assembly 311. That is, when performing the first scanning operation on the sample slide 200, the sample slide 200 is already assembled on the first assembly assembly 311. After performing the first scanning operation and determining that the sample area on the first surface of the sample slide 200 is not coated with the sample to be tested according to the first scanning operation, the controller controls the first assembly assembly 311 to rotate relative to the scanning mechanism 20 so as to drive the sample slide 200 assembled on the first assembly assembly 311 to rotate so that the second surface of the sample slide 200 faces the scanning mechanism 20.

[0093] It should be understood that when performing the first scanning operation on the sample slide 200, the first assembly assembly 311 may not be equipped with the sample slide 200. In this case, when it is determined that the sample area on the first surface of the sample slide 200 is not coated with the sample to be tested, the controller 30 first controls the first assembly assembly 311 to move toward the sample slide 200 so that the sample slide 200 is assembled on the first assembly assembly 311. Then, the controller controls the first assembly assembly 311 to rotate relative to the scanning mechanism 20 so that the sample slide 200 assembled on the first assembly assembly 311 rotates so that the second surface of the sample slide 200 faces the scanning mechanism 20.

[0094] like Figure 3 and Figure 4 As shown, in some other embodiments, the sample image scanning device 100 further includes a second rotation mechanism 32, and the controller 30 performs a rotation operation on the sample slide 200, including:

[0095] The control transfer mechanism 10 transfers the sample slide 200 away from the slide placement area;

[0096] The second rotation mechanism 32 is controlled to receive the sample slide 200 and perform a second rotation operation on the sample slide 200;

[0097] The control transfer mechanism 10 transfers the rotated sample slide 200 to the slide placement area.

[0098] It should be noted that when the controller 30 performs a preset rotation operation on the sample slide 200 so that the second surface of the sample slide 200 faces the scanning mechanism 20, it first controls the transfer mechanism 10 to transfer the sample slide 200 to the second rotation mechanism 32, then controls the second rotation mechanism 32 to receive the sample slide 200 and perform a preset second rotation operation on the sample slide 200, and then controls the transfer mechanism 10 to transfer the rotated sample slide 200 to the slide placement area.

[0099] Specifically, the second rotating mechanism 32 includes a second assembly assembly, and the second assembly assembly is provided with a second assembly position for assembling the sample slide 200, wherein the second assembly position may at least partially overlap with the slide placement area or be spaced apart from the slide placement area.

[0100] Correspondingly, when the controller 30 controls the transfer mechanism 10 to transfer the sample slide 200 to the second rotation mechanism 32, it specifically includes: controlling the transfer mechanism 10 to transfer the sample slide 200 to the second assembly position, so that the second assembly component of the second rotation mechanism 32 receives the sample slide 200. When the controller 30 controls the second rotation mechanism 32 to perform a preset second rotation operation on the sample slide 200, it specifically includes: controlling the second assembly component to rotate relative to the scanning mechanism 20, so as to drive the sample slide 200 assembled on the second assembly component to rotate, so that the second surface of the sample slide 200 faces the scanning mechanism 20.

[0101] like Figure 3 and Figure 4 As shown, exemplarily, the second assembly assembly is spaced apart from the slide placement area, and the second assembly assembly includes a rotation drive 324, a first side member 321, a second side member 322, and a connecting base member 323 connected between the first side member 321 and the second side member 322. The first side member 321, the second side member 322, and the connecting base member 323 cooperate to form an upward-opening second assembly groove 325. The rotation drive 324 is connected to the connecting base member 323 and can drive the connecting base member 323 to rotate. Correspondingly, the controller 30 controls the transfer mechanism 10 to transfer the sample slide 200 to the second assembly position, specifically including: the controlled transfer mechanism 10 flips the sample slide 200 from a horizontal state to a vertical state, and moves the vertically positioned sample slide 200 to the second assembly groove 325 so that the second assembly groove 325 of the second assembly assembly accommodates the sample slide 200. The controller 30 controls the second rotating mechanism 32 to perform a preset second rotation operation on the sample slide 200, specifically including: controlling the rotation drive 324 to drive the drive connecting base 323 to rotate so as to rotate the sample slide 200 housed in the second assembly groove 325.

[0102] like Figure 3As shown, in some other embodiments, when the controller 30 performs a preset rotation operation on the sample slide 200 so that the second surface of the sample slide 200 faces the scanning mechanism 20, it includes controlling the transfer mechanism 10 to perform a preset third rotation operation on the sample slide 200. Specifically, after determining that the sample area on the first surface of the sample slide 200 is not coated with the sample to be tested, the controller 30 controls the transfer mechanism 10 to pick up the sample slide 200 and controls the transfer mechanism 10 to perform a preset third rotation operation on the picked-up sample slide 200. For example, the transfer mechanism 10 includes a transfer manipulator, and the transfer mechanism 10 picks up and holds the sample slide 200 through the transfer manipulator. Controlling the transfer mechanism 10 to perform a preset third rotation operation on the picked-up sample slide 200 specifically includes controlling the transfer manipulator to rotate, so as to drive the sample slide 200 held in the manipulator to rotate.

[0103] In some other embodiments, the first rotating mechanism 31 includes a carrier component for carrying a sample slide 200 located in the slide placement area. When the controller 30 controls the first flipping mechanism to perform a preset first rotation operation on the sample slide 200 located in the slide placement area, it includes controlling the carrier component to rotate to drive the sample slide 200 to rotate so that the second surface of the sample slide 200 faces the scanning mechanism 20.

[0104] Specifically, the carrier component is set corresponding to the slide placement area and is used to carry the sample slide 200 located in the slide placement area. When the controller 30 controls the transfer mechanism 10 to transfer the sample slide 200 to the slide placement area, it specifically controls the transfer mechanism 10 to place the sample slide 200 on the surface of the carrier component. When the controller 30 controls the first flipping mechanism to perform a preset first rotation operation on the sample slide 200 located in the slide placement area, it specifically includes: controlling the carrier component to rotate to drive the sample slide 200 to rotate so that the second surface of the sample slide 200 faces the scanning mechanism 20.

[0105] It should be understood that controlling one of the first rotating mechanism 31, the second rotating mechanism 32, the transfer mechanism 10, and the carrying assembly to perform a corresponding rotation operation on the sample slide 200 specifically involves rotating the sample slide 200 by a preset angle in the thickness direction of the sample slide 200. For example, the preset angle can be 180 degrees, so that before and after rotating the sample slide 200, the opposite sides of the sample slide 200 face the scanning mechanism 20 sequentially, in order to determine the sample bearing condition on the opposite two surfaces of the sample slide 200.

[0106] Please see Figure 5 , Figure 5A logic diagram for the sample image scanning device 100 provided in this application to perform a first scanning operation on the sample slide 200 and / or on the rotated sample slide.

[0107] like Figure 5 As shown, in some embodiments, the controller 30 controls the scanning mechanism 20 to perform a first scanning operation on the sample slide 200, and / or controls the scanning mechanism 20 to perform a first scanning operation on the rotated sample slide 200, including:

[0108] The scanning mechanism 20 scans at least one scanning position on the surface of the sample slide 200 facing the objective lens assembly 21 to obtain a scan image corresponding to the scanning position;

[0109] Perform detection operations on the scanned image;

[0110] When the number of scanned images obtained through the detection operation exceeds a first quantity threshold, it is determined that the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and the sample area is coated with the sample to be tested.

[0111] It should be understood that the controller 30 controls the scanning mechanism 20 to scan the sample slide 200 to obtain the corresponding scanning results, and can simultaneously determine whether the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20 and whether the sample area is coated with the sample to be tested based on the corresponding scanning results.

[0112] Specifically, when the controller 30 controls the scanning mechanism 20 to perform a first scanning operation on the sample slide 200, and / or controls the scanning mechanism 20 to perform a first scanning operation on the rotated sample slide 200, it first controls the scanning mechanism 20 to scan at least one scanning position on the surface of the sample slide 200 facing the objective lens assembly 21 to obtain a scanning image corresponding to the scanning position. After obtaining multiple scanning images, a preset detection operation is performed on the scanning images according to the corresponding scanning positions. It should be noted that the scanning positions are matched to the sample area, that is, when the first surface faces the objective lens assembly of the scanning mechanism, the scanning positions are distributed within the sample area.

[0113] It should be noted that after the controller 30 performs a preset detection operation on the scanned image according to the corresponding scanning position, the result can include at least two possibilities: the scanned image passes the detection operation and the scanned image fails the detection operation. During the process of performing preset detection operations on multiple scanned images, the controller 30 counts the number of scanned images that pass the detection operation, and when it determines that the number of scanned images that pass the detection operation is greater than a preset first threshold, it determines that the sample slide 200 facing the scanning mechanism 20 is coated with the sample to be tested.

[0114] For example, if the first quantity threshold is 3 and the number of scanned images is 5, the controller 30 performs a preset detection operation on the 5 scanned images and counts the number of scanned images that pass the detection operation. When 4 or 5 scanned images pass the detection operation, it can be determined that the sample to be tested is coated on the side of the sample slide facing the scanning mechanism.

[0115] Specifically, when the controller 30 controls the scanning mechanism 20 to scan at least one scanning position on the sample slide 200 to obtain a scanned image corresponding to the scanning position, it includes: controlling the scanning mechanism 20 to scan the scanning position of the sample slide 200 using at least two different scanning distances to obtain a candidate image corresponding to the scanning distance, and using the candidate image obtained by the scanning mechanism 20 scanning the sample slide 200 at one of the scanning positions as the scanned image.

[0116] It should be understood that the scanning distance is the distance between the objective lens assembly 21 of the scanning mechanism 20 and the sample slide 200 when the scanning mechanism 20 scans the sample slide 200. It is known that the closer the scanning distance is to the focal length of the objective lens assembly 21, the higher the clarity of the scan. Therefore, the scanning mechanism 20 uses at least two different scanning distances to scan the scanning position on the sample slide 200, and uses the image with the highest clarity among the candidate images corresponding to the at least two scanning distances as the scanned image. The scanning distance corresponding to the resulting scanned image is closer to the focal length of the objective lens assembly 21.

[0117] like Figure 5 As shown, in some embodiments, when the controller 30 performs a preset detection operation on the scanned image, it specifically includes:

[0118] Determine the scanning distance corresponding to the scanned image;

[0119] Determine whether the scanned image matches the preset cell image model;

[0120] When it is determined that the scanned image matches the preset cell image model and the scanning distance is within the preset distance range, the scanned image is determined to have passed the detection operation.

[0121] It should be understood that the scanned image is one of the candidate images corresponding to at least two scanning distances. The controller 30 first acquires at least two scanning distances used by the scanning mechanism 20 when scanning the scanning position, and then determines the scanning distance corresponding to the scanned image from the at least two scanning distances. The controller 30 also compares the scanned image with a preset cell image model to determine whether the scanned image matches the cell image model. When the controller 30 determines that the scanned image simultaneously satisfies the following conditions: it matches the preset cell image model, and the scanning distance corresponding to the scanned image is within a preset distance range, the controller 30 determines that the scanned image passes the detection operation.

[0122] In some implementations, the scanned image is the one with the highest sharpness among at least two candidate images corresponding to at least two scanning distances. The controller 30 analyzes at least two candidate images to determine the one with the highest sharpness among the candidate images as the scanned image.

[0123] The scanned image is the one with the highest clarity among at least two candidate images corresponding to different scanning distances. For example, the scanning distance corresponding to the scanned image can be the focal length of the scanning mechanism 20, and the distance range is set according to the focal length of the scanning mechanism 20. It should be noted that when the distance between the scanning mechanism 20 and the sample slide 200 is equal to the focal length of the scanning mechanism 20, the scanning mechanism 20 can obtain the candidate image with the highest clarity as the sample image by scanning the sample slide 200.

[0124] It should also be understood that when the sample slide 200 is coated with the sample to be tested on the side facing the scanning mechanism 20, the scanned sample image not only matches the preset cell image model, but the scanning distance corresponding to the scanned image is within the preset distance range; however, when neither of the two surfaces of the sample slide 200 is coated with the sample to be tested, the scanned sample image does not match the preset cell image model. Furthermore, when the sample slide 200 facing the scanning mechanism 20 is not coated with the sample to be tested, but the sample slide 200 facing away from the scanning mechanism 20 is coated with the sample to be tested, the scanning mechanism 20 can scan and obtain the sample to be tested coated on the side of the sample slide 200 facing away from the scanning mechanism 200 through the transparent material of the sample slide 200 itself. Therefore, the sample image obtained by scanning will match the preset cell image model. However, due to the thickness of the sample slide 200, compared with the case where the sample slide 200 facing the scanning mechanism 20 is coated with the sample to be tested, the scanning distance corresponding to the sample image obtained by scanning the sample slide 200 is shorter. The distance range is set according to the focal length of the corresponding scanning mechanism 20, thus causing the corresponding scanning distance to be outside the distance range.

[0125] In some embodiments, after determining the scanning distance corresponding to the scanned image, the controller 30 further includes:

[0126] When the scanned image does not match the preset cell image model, and / or when the scanned distance corresponding to the scanned image is outside the range, the scanned image is determined to have failed the detection operation.

[0127] It should be noted that when a scanned image cannot simultaneously meet the conditions of matching a preset cell image model and the scanning distance corresponding to the scanned image being within a preset distance range, there is a situation where the sample slide 200 near the scanning mechanism 20 is not coated with the sample to be tested. Therefore, when the scanned image does not match the preset cell image model, and / or when the scanning distance corresponding to the scanned image is outside the distance range, it can be determined that the scanned image has not passed the detection operation.

[0128] like Figure 5 As shown, in some embodiments, after performing a preset detection operation on the scanned image, the controller 30 further includes:

[0129] When the number of scanned images obtained through the detection operation is less than or equal to a first quantity threshold, the scanning mechanism 20 is controlled to scan at least one additional scanning position on the sample slide 200 to obtain an additional scanned image corresponding to the additional scanning position, wherein the additional scanning position is matched with the sample area.

[0130] Perform preset detection operations on the additional scan images according to the corresponding additional scan positions;

[0131] When the sum of the number of scanned images and additional scanned images obtained through the detection operation is greater than a preset second quantity threshold, it is determined that the first surface of the sample slide 200 faces the objective lens assembly 21 of the scanning mechanism 20 and the sample area is coated with the sample to be tested, wherein the second quantity threshold is greater than or equal to the first quantity threshold.

[0132] It should be understood that when the number of scanned images obtained through the detection operation is less than or equal to the first quantity threshold, there may be a situation where the sample slide 200 facing the scanning mechanism 20 is coated with the sample to be tested due to the small sample size of the scanned position and the scanned images.

[0133] Therefore, when the number of scanned images obtained through the detection operation is less than or equal to the first quantity threshold, the controller 30 first controls the scanning mechanism 20 to scan at least one additional scanning position on the sample slide 200 to obtain an additional scanned image corresponding to the additional scanning position. Then, a preset detection operation is performed on the additional scanned image according to the corresponding additional scanning position. After this, the number of scanned images obtained through the detection operation and the number of additional scanned images obtained through the detection operation are counted. When the sum of the number of scanned images obtained through the detection operation and the number of additional scanned images is greater than the preset second quantity threshold, the controller 30 determines that the sample to be tested is coated on the side of the sample slide 200 facing the scanning mechanism 20. It is easy to see that the second quantity threshold is greater than or equal to the first quantity threshold. It should be noted that the additional scanning positions are matched to the sample area, that is, when the first surface faces the objective lens assembly of the scanning mechanism, the additional scanning positions are distributed within the sample area.

[0134] This embodiment introduces additional scanning positions and corresponding additional scanning images to assist in the judgment when the number of scanned images obtained through the detection operation is less than or equal to a first quantity threshold. This increases the number of scanned image samples for scanning the sample slide 200 and improves the accuracy of judging whether the side of the sample slide 200 facing the scanning mechanism 20 is coated with the sample to be tested.

[0135] It should be noted that, in addition to the sample area for coating the sample to be tested, a marking area is also provided on the first surface of the sample slide 200. This marking area is used to provide a space for printing barcodes or setting other markings, and the barcode or other markings characterize the sample information corresponding to the sample slide 200. Furthermore, the marking area also corresponds to the first surface of the sample slide 200.

[0136] It should be noted that scanning at least one of the sample area and the marking area outside the sample area can determine whether the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20. Therefore, directly scanning the sample area can simultaneously determine whether the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20 and whether the sample area is coated with the sample to be tested, based on the corresponding scanning results. For details, please refer to the specific description of the sample image scanning device 100 performing the first scanning operation on the sample slide 200 and / or performing the first scanning operation on the rotated sample slide 200 provided in this application specification.

[0137] In another implementation, the controller 30 controls the scanning mechanism 20 to perform a first scanning operation on the sample slide 200, and further includes:

[0138] The scanning mechanism 20 is controlled to perform a scanning operation on at least one of the sample area and the marking area outside the sample area to determine whether the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20;

[0139] The scanning mechanism 20 is controlled to scan the sample area to determine whether the sample area is coated with the sample to be tested.

[0140] Specifically, since both the sample area and the labeling area are located on the first surface of the sample slide 200, when the controller 30 controls the scanning mechanism 20 to perform the first scanning operation on the sample slide 200, it can first control the scanning mechanism 20 to scan at least one of the sample area and the labeling area outside the sample area to determine whether the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20. Then, after determining that the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20, it can then control the scanning mechanism 20 to perform a scanning operation on the sample area to determine whether the sample area is coated with the sample to be tested.

[0141] Taking the scanning mechanism 20 scanning the marking area to determine whether the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20 as an example, the controller 30 first controls the scanning mechanism 20 to perform a scanning operation in the direction of the marking area to obtain the corresponding marking scan image, and then compares the marking scan image with the pre-configured marking features. If the comparison determines that the marking scan image matches the marking features, it can be determined that the first surface of the sample slide 200 is facing the objective lens assembly 21 of the scanning mechanism 20. If the comparison determines that the marking scan image does not match the marking features, it can be determined that the first surface of the sample slide 200 is still not facing the objective lens assembly 21 of the scanning mechanism 20.

[0142] like Figure 3 As shown, in some embodiments, the sample image scanning device 100 further includes a recovery mechanism 40 for recovering the sample slide 200, and the controller 30 is further used for:

[0143] When it is determined that neither the first nor the second surface of the sample slide 200 is coated with the sample to be tested, the control transfer mechanism 10 transfers the sample slide 200 to the recycling mechanism 40.

[0144] The control recovery mechanism 40 receives the sample slide 200 and performs a preset recovery operation on the sample slide 200.

[0145] Specifically, the recycling mechanism 40 is electrically connected to the controller 30 and corresponds to a preset recycling position setting. The controller 30 is used to control the transfer mechanism 10 to transfer the sample slide 200 to the recycling position, so that the recycling mechanism 40 receives the sample slide 200 transferred to the recycling position and performs a preset recycling operation on the sample slide 200.

[0146] Furthermore, the retrieval mechanism 40 is also used to feed a slide basket with at least one empty slide space to the retrieval position, and the controller 30 is also used to control the transfer mechanism 10 to transfer the sample slides 200 to the empty slide space in the slide basket, and to control the retrieval device to transfer the slide basket away from the retrieval position when the number of slides in the slide basket reaches a preset slide number threshold. For example, when the empty slide space in the slide basket is full, the controller controls the retrieval device to transfer the slide basket away from the retrieval position. Even further, after the slide basket with the number of slides reaching the preset slide number threshold has been transferred away from the retrieval position, the controller 30 is also used to control the retrieval mechanism 40 to feed another slide basket with at least one empty slide space to the retrieval position, so as to achieve efficient sample image scanning of a large number of sample slides 200.

[0147] like Figure 3 As shown, in some embodiments, the sample image scanning device 100 further includes an identification mechanism 50, which is used to identify sample information of the sample slide 200.

[0148] Specifically, the identification mechanism 50, such as a camera or barcode scanner, is electrically connected to the controller 30 and is used to perform a preset identification operation on the sample slide 200 to identify the sample information of the sample slide 200. For example, at least one surface of the sample slide 200 is provided with an identification area to set a barcode or other identifier on the identification area. It is easy to understand that the barcode or other identifier represents the sample information corresponding to the sample slide 200. When the identification mechanism 50 identifies the sample information of the sample slide 200, it specifically includes: performing an identification operation on at least the identification area of ​​the sample slide 200 to identify and obtain the sample information of the sample slide 200.

[0149] For example, the sample image scanning device 100 provided in this application may identify the sample information of the sample slide 200 by the identification mechanism 50 before the scanning mechanism 20 performs the first scanning operation on the sample slide 200, so that after the scanning operation on the sample slide 200 is completed, the sample information of the sample slide 200 and the scanning result of the sample slide 200 are associated and recorded into the controller 30.

[0150] In some embodiments, before controlling the scanning mechanism 20 to perform the first scanning operation on the sample slide 200, the controller 30 is further configured to: identify the sample information of the sample slide 200 through the identification mechanism 50; match the operating parameters and / or cell image model of the scanning mechanism 20 to the sample slide 200 according to the sample information; and perform a corresponding scanning operation on the sample slide 200 according to the operating parameters and / or cell image model of the scanning mechanism 20, wherein the corresponding scanning operation includes, but is not limited to, the first scanning operation and the second scanning operation. For example, the operating parameters of the scanning mechanism 20 include, but are not limited to, the scanning center and scanning focal length of the scanning mechanism 20.

[0151] This application also provides a sample image scanning method, which aims to solve the problem that it is difficult to determine whether the sample slide carries the sample to be tested, thus making it difficult to scan the sample slide quickly and accurately.

[0152] It should be noted that the sample image scanning method can be specifically applied to the sample image scanning device 100 provided in the above embodiments. The steps of the sample image scanning method provided in this application will be specifically described below using the sample image scanning device 100 provided in the above embodiments as an example. However, it should be understood that the sample image scanning method is not limited to the sample image scanning device 100 provided in the above embodiments.

[0153] Please see Figure 6 , Figure 6 This is a schematic diagram of the sample image scanning method provided in the embodiments of this application.

[0154] like Figure 6As shown, the sample image scanning method provided in this application embodiment includes steps S1-S4:

[0155] Step S1: Control the transfer mechanism to transfer the sample slide to the slide placement area;

[0156] Step S2: Control the scanning mechanism to perform a first scanning operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested;

[0157] Step S3: When it is determined that the first surface of the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested.

[0158] Step S4: When it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested.

[0159] Specifically, the sample image scanning device includes a transfer mechanism, a scanning mechanism, and a controller. The sample slide has a first surface and a second surface disposed opposite to the first surface, and the sample image scanning device 100 is pre-set with at least one slide placement area.

[0160] Specifically, the transport mechanism is used to transport sample slides, and the scanning mechanism is set up corresponding to the slide placement area and used to scan the sample slides located in the slide placement area. The controller is electrically connected to the transport mechanism and the scanning mechanism, and when scanning the sample image of the sample slide, it is used to: control the transport mechanism to transport the sample slide to the slide placement area; control the scanning mechanism to perform a first scanning operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; when it is determined that the first surface of the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; when it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain the image information of the sample to be tested.

[0161] By first controlling the transfer mechanism to transfer the sample slide to the slide placement area, and then controlling the scanning mechanism to perform a first scan operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested, and then controlling the scanning mechanism to perform a second scan operation on the sample area to obtain the image information of the sample to be tested, the sample slide can be scanned accurately, thereby improving the accuracy, clarity and efficiency of scanning the sample slide.

[0162] In summary, this application provides a sample image scanning device and a sample image scanning method. The sample image scanning device includes a transfer mechanism, a scanning mechanism, and a controller. The device also includes a slide placement area. The transfer mechanism is used to transfer sample slides, each having a first surface and a second surface opposite to the first surface. The first surface has a sample area for coating the sample to be tested. The scanning mechanism scans the sample slide located in the slide placement area. The controller is electrically connected to the transfer mechanism and the scanning mechanism. The controller is used to: control the transfer mechanism to transfer the sample slide to the slide placement area; control the scanning mechanism to perform a first scan operation on the sample slide to determine whether the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; and when the first surface of the sample slide is determined to be facing the objective lens assembly of the scanning mechanism, the controller performs a first scan operation on the sample slide to determine whether the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested. When the objective lens assembly whose surface is not facing the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform a first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; when it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested, thereby solving the problem of difficulty in determining the coating status of the sample to be tested on the sample slide, wherein the coating status is, for example, whether the sample to be tested is coated on the sample slide and the specific coating position of the sample slide, etc. Therefore, this application improves the accuracy, clarity and efficiency of scanning the sample slide.

[0163] It should be understood that the modular structure diagrams shown in the accompanying drawings are merely illustrative and do not necessarily include all the connections between structures. In the description of this application, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linkage" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0164] It should also be understood that the terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the scope of the application. As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural forms unless the context clearly indicates otherwise.

[0165] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0166] It should also be understood that the term "and / or" as used in this specification and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes such combinations. It should be noted that, herein, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or system. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or system that includes that element.

[0167] The sequence numbers of the embodiments in this application are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments. The above descriptions are merely specific implementations of this application, but the scope of protection of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and these modifications or substitutions should all be covered within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A sample image scanning device, characterized in that, include: A transfer mechanism for transferring sample slides, the sample slides having a first surface and a second surface disposed opposite to the first surface, the first surface having a sample area for coating the sample to be tested; The scanning mechanism is provided with a slide placement area for scanning the sample slide located in the slide placement area. A controller, electrically connected to the transfer mechanism and the scanning mechanism, is used for: The transfer mechanism is controlled to transfer the sample slide to the slide placement area; The scanning mechanism is controlled to perform a first scanning operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; When it is determined that the first surface of the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested. When it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested. The controller controls the scanning mechanism to perform a first scan of the sample slide, including: The scanning mechanism is controlled to scan at least one scanning position on the surface of the sample slide facing the objective lens assembly to obtain a scanning image corresponding to the scanning position; Perform a detection operation on the scanned image; When the number of scanned images obtained through the scanning operation exceeds a first quantity threshold, it is determined that the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and that the sample area is coated with the sample to be tested.

2. The sample image scanning device according to claim 1, characterized in that, After controlling the scanning mechanism to perform the first scanning operation on the rotated sample slide, the controller is further configured to: When it is determined that the first surface of the rotated sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform the second scanning operation on the sample area to obtain image information of the sample to be tested; When it is determined that the first surface of the sample slide after rotation is still not facing the objective lens assembly of the scanning mechanism, and / or when it is determined that the sample area is not coated with the sample to be tested, the sample slide is judged to be an abnormal slide.

3. The sample image scanning device according to claim 1, characterized in that, The controller performs a detection operation on the scanned image, including: Determine the scanning distance corresponding to the scanned image; Determine whether the scanned image matches a preset cell image model; When it is determined that the scanned image matches a preset cell image model and the scanning distance is within a preset distance range, the scanned image is determined to have passed the detection operation.

4. The sample image scanning device according to claim 1, characterized in that, After the controller performs a detection operation on the scanned image, it further includes: When the number of scanned images obtained through the detection operation is less than or equal to the first number threshold, the scanning mechanism is controlled to scan at least one additional scanning position on the surface of the sample slide facing the objective lens assembly, wherein the additional scanning position matches the sample area; A detection operation is performed based on the additional scan image obtained by scanning the additional scan positions; When the sum of the number of the scanned images and the additional scanned images obtained through the detection operation is greater than a second quantity threshold, it is determined that the first surface of the sample slide faces the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, wherein the second quantity threshold is greater than or equal to the first quantity threshold.

5. The sample image scanning device according to claim 2, characterized in that, The controller controls the scanning mechanism to perform a first scanning operation on the sample slide, and further includes: The scanning mechanism is controlled to scan at least one of the sample area and the marking area outside the sample area to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism; The scanning mechanism is controlled to scan the sample area to determine whether the sample area is coated with the sample to be tested.

6. The sample image scanning device according to claim 2, characterized in that, The sample image scanning device also includes a retrieval mechanism, and the controller is further configured to: When the sample slide is determined to be an abnormal slide, the transfer mechanism is controlled to transfer the sample slide to the recycling mechanism; The recycling mechanism is controlled to receive the sample slide and perform a preset recycling operation on the sample slide.

7. The sample image scanning device according to any one of claims 1-6, characterized in that, The sample image scanning device further includes a first rotation mechanism, and the controller performs a rotation operation on the sample slide, including: The first rotating mechanism is controlled to perform a first rotation operation on the sample glass slide located in the glass slide placement area.

8. The sample image scanning device according to any one of claims 1-6, characterized in that, The sample image scanning device further includes a second rotating mechanism, and the controller rotates the sample slide, including: The transfer mechanism is controlled to transfer the sample slide away from the slide placement area; The second rotating mechanism is controlled to receive the sample slide and perform a second rotation operation on the sample slide; The transfer mechanism is controlled to transfer the rotated sample slide to the slide placement area.

9. The sample image scanning device according to any one of claims 1-6, characterized in that, The controller performs a preset rotation operation on the sample slide, including: The transfer mechanism is controlled to perform a preset third rotation operation on the sample slide.

10. The sample image scanning device according to claim 7, characterized in that, The first rotating mechanism includes a support component for carrying the sample slide located in the slide placement area. When the controller controls the first rotating mechanism to perform a preset first rotation operation on the sample slide located in the slide placement area, it includes: The carrier component is controlled to rotate so that the sample slide rotates so that the second surface of the sample slide faces the scanning mechanism.

11. The sample image scanning device according to claim 1, characterized in that, The sample image scanning device also includes an identification mechanism for identifying sample information of the sample slide.

12. A sample image scanning method, characterized in that, The method, using the sample image scanning device according to any one of claims 1-11, comprises: The control transfer mechanism transfers the sample slides to the slide placement area; The scanning mechanism is controlled to perform a first scanning operation on the sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested; When it is determined that the first surface of the sample slide is not facing the objective lens assembly of the scanning mechanism, the sample slide is rotated, and the scanning mechanism is controlled to perform the first scanning operation on the rotated sample slide to determine whether the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and whether the sample area is coated with the sample to be tested. When it is determined that the first surface of the sample slide is facing the objective lens assembly of the scanning mechanism and the sample area is coated with the sample to be tested, the scanning mechanism is controlled to perform a second scanning operation on the sample area to obtain image information of the sample to be tested.

Images