A moisturizing and antibacterial foot cream containing jasmine extract

Abstract

The present invention discloses a moisturizing and antibacterial foot cream containing jasmine extract. The jasmine extract is introduced into the effective component of the scheme of the present invention. The oil content of jasmine is generally 0.2-0.3%, so that the jasmine extract obtained by extraction can inhibit the evaporation of skin moisture, thereby improving the degree of skin dryness and cracking, and keeping the skin in a good and healthy state. In addition, jasmine essential oil also contains jasmone and polyphenols, which can absorb moisture from the air. The polyphenol molecular structure contains multiple phenolic hydroxyl groups, which can inhibit the activity of hyaluronidase and reduce the decomposition of hyaluronic acid, and can achieve a deep moisturizing effect. This scheme uses dimethyl ether as an extractant to extract jasmine essential oil by extraction, ensuring that the extracted essential oil maintains a good color; and the obtained jasmine extract is embedded by a composite coacervation method to obtain a jasmine extract preserved in the form of microcapsules, which can improve the storage stability of the jasmine extract.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to a moisturizing and antibacterial foot cream containing jasmine extract. Background Art

[0002] As people's living standards continue to improve, the need for skin care has become more comprehensive, and foot skin care has gradually attracted people's attention. Under normal circumstances, a skin with normal metabolism has about 10 to 15 layers of stratum corneum, and the top layer will continue to fall off to make room for the new cells below to move upward. Although the cells of the stratum corneum are dead cells, they are an important barrier to protect the skin, which can prevent direct invasion of foreign bacteria and loss of skin moisture. A skin with normal metabolism does not need to rely on external force to remove keratin, because after a certain period of time, the outermost cells will fall off automatically. The metabolic time from life to death of cells is about 14 to 28 days for ordinary people. The older you are, the longer it takes for metabolism, which can reach 35 days or even longer. However, due to the deterioration of external environmental conditions, unbalanced diet, abnormal lifestyle, staying up late, smoking, drinking, emotions and other factors, the metabolic rate often slows down. Abnormal metabolism prevents keratin cells from falling off naturally, and they accumulate thickly on the surface, resulting in rough and dull skin, which is keratin thickening. Especially the skin on the soles of the feet, which is often exposed to acids, alkalis, and organic chemical solvents, which dissolve sebum. The feet also often need to bear the weight of the whole body and rub against shoes and socks, which accelerates cell death and slows down the metabolic rate. Aging cells cannot fall off by themselves within a metabolic cycle, resulting in thickening of the keratin. In severe cases, it affects walking comfort. The stratum corneum on the soles of the feet is thick and rich in keratin, which provides conditions for fungal growth and is prone to skin diseases such as chapped skin and tinea pedis.

[0003] Currently, the exfoliating products on the market include cuticle-softening ointments, creams, essence gels, facial masks, etc., but most of them are for softening the cuticle on the face and are not suitable for the feet. They also contain irritating substances such as salicylic acid and preservatives, which make the skin feel sticky after application.

[0004] Jasmine is widely planted in Fuzhou, Fujian. It is rich in resources, contains a variety of active ingredients, has a wide range of pharmacological effects, and is a Chinese herbal medicine. The oil content in jasmine is generally 0.2-0.3%. The extracted jasmine essential oil has a moisturizing effect, thereby improving the degree of skin dryness and cracking, and keeping the skin in a good and healthy state. Jasmine essential oil also contains jasmone and polyphenols. The polyphenol molecular structure contains multiple phenolic hydroxyl groups, which can inhibit the activity of hyaluronidase and reduce the decomposition of hyaluronic acid, thereby achieving a deep moisturizing effect. However, during the extraction process, the heat-sensitive components in jasmine will be affected by temperature and oxygen, which will make the extract yellow and lose its fragrance. The extracted jasmine essential oil is also volatile, poorly water-soluble, and sensitive to light, heat, and temperature, which limits its application in cosmetics. Therefore, if it is possible to extract jasmine essential oil (extract) with good performance preservation and use it in soft foot cream, it will bring positive and practical significance to the quality improvement of soft foot cream products. Summary of the invention

[0005] In view of this, the object of the present invention is to provide a moisturizing and antibacterial foot cream containing jasmine extract which is reliable in implementation, convenient in preparation and has good application effect.

[0006] In order to achieve the above technical objectives, the technical solution adopted by the present invention is:

[0007] A moisturizing and antibacterial foot cream containing jasmine extract, comprising the following raw materials in percentage by weight:

[0008]

[0009]

[0010] Wherein, the effective ingredients include jasmine extract.

[0011] As a possible implementation mode, further, the effective ingredients described in this solution include the following extract raw materials in parts by weight:

[0012]

[0013] As a preferred embodiment, preferably, the preparation method of the jasmine extract in the effective ingredients described in this scheme includes:

[0014] The jasmine flowers are placed in a fragrance exhalation chamber with preset temperature, humidity and oxygen control parameters to release the fragrance, and the jasmine fragrance released by the jasmine flowers is directionally captured in an activated carbon adsorption column by suction through a vacuum pump until the jasmine flowers wither and finish exhaling the fragrance, and then the activated carbon is placed in an extraction tank for sealed vacuuming, and dimethyl ether extraction agent is also injected, and extraction is carried out for 48 to 49 minutes at a temperature of 40.5°C and a solvent-to-solid ratio of 3.4:1; finally, the extract is transferred to an evaporation tank for post-treatment, dimethyl ether is gasified and separated, and jasmine essential oil, i.e. jasmine extract, is extracted, and then the jasmine essential oil is encapsulated by a composite coacervation method to obtain jasmine essential oil microcapsules, i.e. microcapsules encapsulating the jasmine extract.

[0015] As a preferred embodiment, preferably, the core-to-wall ratio of the jasmine essential oil microcapsules described in this scheme is 2.0:1.0, the wall material ratio is 1.0:1.0, the encapsulation temperature is 35° C., and the amount of curing agent is 0.61 μg / L.

[0016] As a preferred embodiment, preferably, among the effective ingredients described in this scheme, the ivy extract and the sargassum extract are mixed together, and the preparation method thereof is as follows:

[0017] According to the addition ratio of 18-22:18-22, ivy and Sargassum are washed, dried at 40°C, and then cut into preset specifications (small pieces for easy feeding and crushing), put into a grinder to be ground into powder, and passed through a 100-mesh sieve to obtain the undersize, and then the hemicellulase-assisted extraction method is used to extract the undersize under the conditions of a solid-liquid ratio of 1:35, an extraction time of 1.5h, an extraction temperature of 70°C, and an enzyme concentration of 2.5% (the polysaccharide extraction rate can reach 18.56%) to obtain a mixed extract B1 containing ivy extract and Sargassum extract.

[0018] As a preferred embodiment, preferably, the preparation method of the purslane extract in the effective ingredients described in this scheme includes:

[0019] Purslane was subjected to ultrasonic extraction treatment for 80 minutes under the conditions of 65% ethanol concentration, solid-liquid ratio of 1:5, ultrasonic power of 360 W, and temperature of 70°C to obtain a purslane extract.

[0020] As a preferred embodiment, preferably, the preparation method of the Pseudostellaria heterophylla extract in the effective ingredients described in this scheme includes:

[0021] The Radix Pseudostellariae was crushed with a traditional Chinese medicine grinder and passed through a 40-mesh sieve to obtain material A1, which was then added to 40% ethanol by mass and subjected to microwave extraction for 30 minutes at a microwave temperature of 50°C and a power of 600 W. The precipitate was taken and the above steps were repeated once to obtain an extract B2 containing the Radix Pseudostellariae extract.

[0022] As a preferred embodiment, preferably, the mixing mass ratio of the material A1 and 40% ethanol by volume in this solution is 1:20.

[0023] Based on the above, the present invention also provides a method for preparing a moisturizing and antibacterial foot cream containing jasmine extract, which comprises:

[0024] S01, mixing preset amounts of sodium hyaluronate, carbomer U20, butylene glycol, glycerin, disodium EDTA, xanthan gum, polydimethylsiloxane, polydimethylsiloxane / vinyl dimethylsiloxane crosspolymer, butylated hydroxytoluene, caprylic / capric triglyceride, polysorbate 80, jojoba seed oil, cetostearyl alcohol and deionized water at a preset temperature to obtain a mixed material A;

[0025] S02, cooling the mixed material A to 40-45° C., then adding the functional ingredients and homogenizing at a low speed to obtain a mixed material B;

[0026] S03. Mix cucumis alcohol and caprylhydroxamic acid with mixture B, stir until uniform, and prepare a foot softening ointment.

[0027] As a preferred implementation mode, preferably, in the present solution S01, the components are mixed at 80°C.

[0028] The scheme of the present invention applies jasmine extract to a moisturizing and antibacterial foot cream. Since jasmine itself is an excellent natural product, the jasmine extract obtained by extracting it can inhibit the evaporation of skin moisture. It is combined with a variety of Chinese medicinal materials to increase its moisturizing, antibacterial and anti-inflammatory effects.

[0029] In addition, the Chinese medicinal materials such as jasmine involved in the scheme of the present invention have high yield, wide distribution, low price, and relatively simple extraction process, low production cost, and compared with the existing soft foot cream, it is natural and environmentally friendly, does not contain raw materials that are irritating to the skin, and has good moisturizing and antibacterial effects. In order to solve the problem that the color and smell are easily affected by temperature during the extraction process of jasmine, subcritical extraction technology can be used to extract jasmine essential oil. The low pressure and anaerobic conditions of subcritical extraction reduce the influence of long heating time and high temperature on heat-sensitive components during the extraction process, ensuring that the extracted essential oil maintains its fragrance and good color. In order to solve the problem that jasmine essential oil is volatile, unstable, and not easily soluble in water, at the same time, this scheme also uses a composite coacervation method to encapsulate jasmine essential oil to improve its stability.

[0030] By adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art:

[0031] 1. The jasmine extract is introduced into the efficacy component of the scheme of the present invention. The oil content in jasmine is generally 0.2-0.3%, so that the jasmine essential oil (jasmine extract) extracted can inhibit the evaporation of skin moisture, thereby improving the degree of skin dryness and cracking, and keeping the skin in a good healthy state. In addition, jasmine essential oil also contains jasmone and polyphenols, which can absorb moisture from the air. The polyphenol molecular structure contains multiple phenolic hydroxyl groups, which can inhibit the activity of hyaluronidase and reduce the decomposition of hyaluronic acid, and can achieve a deep moisturizing effect. This scheme uses dimethyl ether as an extractant to extract jasmine essential oil by extraction, ensuring that the extracted essential oil maintains a good color; and the obtained jasmine extract is embedded by a composite coagulation method, and the jasmine extract prepared in the form of microcapsules can improve the storage stability of jasmine essential oil (jasmine extract).

[0032] 2. The effective ingredients of the scheme of the present invention are further added with unique Chinese herbal medicine compatibility (ivy extract, sargassum extract, purslane extract, and Pseudostellaria extract) on the basis of adding jasmine extract obtained by extraction method. Among them, the main components of sargassum extract and ivy extract are polysaccharides, which have the characteristics of swelling in water without dissolving and slow release, and show good hygroscopic, moisturizing and skin nutrition effects in terms of physical and chemical properties, and are non-irritating. In addition, plant polysaccharides also have antibacterial and antiviral effects. The chemical components of purslane extract mainly include flavonoids, polyphenols, terpenes and sterols, coumarins, alkaloids, polysaccharides, organic acids, etc., and the rich chemical components make it have good antibacterial and antioxidant effects. Pseudostellaria root has the effects of clearing away heat and dampness, antibacterial and anti-inflammatory, can relieve skin itching, and Pseudostellaria extract also has the effect of softening keratin.

[0033] 3. The functional ingredients added in the solution of the present invention have good moisturizing, antibacterial and keratin softening effects. At the same time, the formula of the present invention is reasonable and has good effects on anti-inflammatory and moisturizing.

[0034] 4. The present invention adopts different extraction processes for different Chinese herbal medicines, rather than a one-pot method, so that the present solution can more effectively retain the active ingredients in the Chinese herbal medicines and improve the utilization rate of the medicinal materials.

[0035] 5. The effective ingredients used in the scheme of the present invention are extracted from raw materials and have been proven to be safe and non-irritating to the skin through experiments.

[0036] 6. The effective ingredients of the scheme of the present invention contain natural keratin softening and moisturizing and antibacterial factors. Compared with the existing moisturizing and antibacterial soft foot cream, it is natural and environmentally friendly, does not contain raw materials that irritate the skin, but can also achieve good moisturizing and antibacterial effects. DETAILED DESCRIPTION

[0037] The present invention will be further described in detail below in conjunction with the following examples. It is particularly noted that the following examples are only used to illustrate the present invention, but are not intended to limit the scope of the present invention. Similarly, the following examples are only partial embodiments of the present invention rather than all embodiments, and all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention.

[0038] Example 1

[0039] The present embodiment provides a moisturizing and antibacterial foot cream containing jasmine extract, which comprises the following raw materials in percentage by weight:

[0040]

[0041]

[0042] Wherein, the functional component includes jasmine extract; the functional component of this embodiment includes the following extract raw materials in parts by weight:

[0043]

[0044] In addition, the preparation method of the functional ingredient of this embodiment includes:

[0045] (1) Preparation of jasmine extract: jasmine is placed in a fragrance exhalation chamber with temperature, humidity and oxygen control parameters to release the fragrance, and the jasmine fragrance released by the jasmine is directionally captured in an activated carbon adsorption column by suction through a vacuum pump until the jasmine wilts and the fragrance is exhaled, and then the activated carbon is placed in an extraction tank for sealing and vacuuming, and dimethyl ether is injected as an extractant, and extraction is carried out at a temperature of 40.5° C. and a solvent-to-solid ratio of 3.4:1 for 48 to 49 minutes; finally, the extract is transferred to an evaporator for post-treatment, and the dimethyl ether is gasified and separated to extract jasmine essential oil, i.e., jasmine extract, and then the jasmine essential oil is encapsulated by a composite coacervation method to obtain jasmine essential oil microcapsules, i.e., microcapsules encapsulating jasmine extract, wherein the core-to-wall ratio of the jasmine essential oil microcapsules is 2.0:1.0, the wall-to-material ratio is 1.0:1.0, the encapsulation temperature is 35° C., and the amount of curing agent is 0.61 μg / L;

[0046] (2) Preparation of a mixture of ivy extract and sargassum extract: ivy and sargassum were washed and dried at 40°C according to an addition ratio of 18-22:18-22, and then cut into pieces to a preset specification (small pieces for easy feeding and crushing), put into a grinder to be ground into powder, and passed through a 100-mesh sieve to obtain the undersize, and then the undersize was extracted by hemicellulase-assisted extraction method under the conditions of a solid-liquid ratio of 1:35, an extraction time of 1.5 h, an extraction temperature of 70°C, and an enzyme concentration of 2.5% (the polysaccharide extraction rate can reach 18.56%) to obtain a mixed extract B1 containing ivy extract and sargassum extract;

[0047] (3) Preparation of purslane extract: Purslane was subjected to ultrasonic extraction for 80 min at 65% ethanol concentration, solid-liquid ratio of 1:5, ultrasonic power of 360 W, and temperature of 70° C. to obtain purslane extract;

[0048] (4) Preparation of Pseudostellariae Radix Extract: Pseudostellariae Radix was pulverized by a traditional Chinese medicine grinder and passed through a 40-mesh sieve to obtain material A1, which was then added to 40% by mass ethanol and subjected to microwave extraction for 30 min at a microwave temperature of 50°C and a power of 600 W. The precipitate was taken and the above steps were repeated once to obtain an extract B2 containing Pseudostellariae Radix Extract; wherein the mixing mass ratio of material A1 to 40% by volume ethanol was 1:20.

[0049] (5) The prepared jasmine essential oil microcapsules, the mixed extract B1 of ivy extract and Sargassum extract, the purslane extract and the extract B2 containing Pseudostellaria sibiricum extract are uniformly mixed to obtain the effective component.

[0050] This embodiment also provides a method for preparing a moisturizing and antibacterial foot cream containing jasmine extract, which uses the above-prepared functional ingredients, including:

[0051] S01, mixing preset amounts of sodium hyaluronate, carbomer U20, butylene glycol, glycerin, disodium EDTA, xanthan gum, dimethicone, dimethicone / vinyl dimethicone crosspolymer, butylated hydroxytoluene, caprylic / capric triglyceride, polysorbate 80, jojoba seed oil, cetostearyl alcohol and deionized water at 80° C. to obtain a mixed material A;

[0052] S02, cooling the mixed material A to 40-45° C., then adding the functional ingredients and homogenizing at a low speed to obtain a mixed material B;

[0053] S03. Mix cucumis alcohol and caprylhydroxamic acid with mixture B, stir until uniform, and prepare a foot softening ointment.

[0054] Example 2

[0055] This embodiment is substantially the same as the above-mentioned embodiment 1, except that the formula of the foot softening cream and the formula of the functional ingredients of this embodiment are different, as follows:

[0056] The present embodiment provides a moisturizing and antibacterial foot cream containing jasmine extract, which comprises the following raw materials in percentage by weight:

[0057]

[0058]

[0059] Wherein, the functional component includes jasmine extract; the functional component of this embodiment includes the following extract raw materials in parts by weight:

[0060]

[0061] The preparation method of the effective ingredients and the preparation method of the foot softening cream of this embodiment are the same as those in Example 1, and will not be described in detail.

[0062] Example 3

[0063] This embodiment is substantially the same as the above-mentioned embodiment 1, except that the formula of the foot softening cream and the formula of the functional ingredients of this embodiment are different, as follows:

[0064] The present embodiment provides a moisturizing and antibacterial foot cream containing jasmine extract, which comprises the following raw materials in percentage by weight:

[0065]

[0066]

[0067] Wherein, the functional component includes jasmine extract; the functional component of this embodiment includes the following extract raw materials in parts by weight:

[0068]

[0069] The preparation method of the effective ingredients and the preparation method of the foot softening cream of this embodiment are the same as those in Example 1, and will not be described in detail.

[0070] Comparative Example 1

[0071] This comparative example is substantially the same as the above-mentioned Example 1, except that the formula of the foot softening cream and the formula of the functional component of this example are different. Specifically, the functional component of this comparative example does not contain jasmine extract, and the addition amounts of the remaining raw materials are also different, as follows:

[0072] This comparative example is a moisturizing and antibacterial foot cream, which includes the following raw materials in percentage by weight:

[0073]

[0074] The effective ingredients described in this embodiment include the following extract raw materials in parts by weight:

[0075]

[0076] The preparation method of the effective ingredients and the preparation method of the foot softening cream of this embodiment are the same as those in Example 1, and will not be described in detail.

[0077] Comparison test

[0078] The foot creams prepared in Examples 1-3 and Comparative Example 1 were tested for the following items:

[0079] 1. Test on the "moisture-locking" ability of the active ingredients containing jasmine extract

[0080] 1. Determination of transepidermal water loss rate

[0081] Thirty healthy subjects were recruited, with the following conditions: half male and half female, aged 20 to 30 years old, without severe skin diseases, immune deficiency or autoimmune diseases, no history of severe allergies to skin care cosmetics, and no use of hormone drugs in the past month. The subjects could not use any cosmetics or skin medications in the past 3 days. Before the test, the test site was thoroughly cleaned with a mild cleanser, and the moisture was wiped clean with a paper towel and kept exposed.

[0082] The subjects should sit quietly in a room with constant temperature (25℃) and relative humidity (40%-50%) for 30 minutes. During this period, they are not allowed to drink water or other beverages, leave the test site at will and keep their emotions stable.

[0083] Before the test, mark the test area with a marker pen. The general marking range is 3cm×3cm. Multiple areas can be marked at the same test site at the same time. The interval between areas must not be less than 2cm. The sample group and the control group are randomly distributed in different foot areas. Then use latex gloves to evenly apply equal amounts of the active ingredients containing jasmine extract and the 10% glycerol control group to the corresponding test areas. First measure the basal value of each test area, and then measure the change values ​​Xnt and X0t of the sample group and the control group at the test points: 10min, 60min, and 120min respectively. Each test point is tested five times in parallel and the average value is taken. The result is expressed as g / (h·m 2 ) is represented by the recorded results as shown in Table 1, wherein the smaller the g / (h·m2) value is, the better the moisturizing effect is.

[0084] Table 1 Effects of different concentrations of functional ingredients on skin moisturizing

[0085]

[0086] As can be seen from Table 1, the transepidermal water loss values ​​all show a downward trend, and the more effective ingredients a product contains, the better the moisturizing effect.

[0087] 2. Hyaluronidase inhibition rate

[0088] (1) Sample processing

[0089] Accurately weigh 1g of sample and dissolve it in 20mL of deionized water. After stirring, mixing, precipitation and other steps, the clarified solution is tested. Among them, water-soluble gels and water-soluble gels can be dissolved directly; emulsifiers must be identified before dissolving. If they are emulsified (W / O) type, the transformation dilution method should be adopted to make them emulsified (O / W) type.

[0090] (2) Determination of hyaluronidase inhibition rate

[0091] Take clean test tubes, add 0.5mL hyaluronidase solution and 0.1mL 0.25mmol / LCaCl2 solution to each test tube, place the test tube in a 37℃ incubator for 20min; add 0.5mL of a certain concentration of the sample solution to be tested, continue to incubate at 37℃ for 20min; then add 0.5mL sodium hyaluronate solution, place in a 37℃ incubator for 30min, then take it out and place it at room temperature for 5min; add 0.1mL 0.4mol / L NaOH solution and 0.5mL acetobutanone solution. After heating in boiling water for 15mAn in a water bath, immediately cool it with ice water for 5min; add 1.0mL Ehrlich reagent and dilute it with 3.0mL anhydrous ethanol, place it for 20min to develop color, and measure its absorbance value with a spectrophotometer.

[0092] Hyaluronic acid inhibition rate (%) = [(AB) - (CD)] / (AB) × 100%

[0093] Wherein: A is the OD value of the control solution; B is the OD value of the control blank solution; C is the OD value of the sample solution to be tested; D is the OD value of the sample blank.

[0094] Table 2 Inhibitory effect of different concentrations of active ingredients on hyaluronidase

[0095]

[0096] It can be seen from Table 2 that the greater the concentration of the active ingredient, the stronger the inhibitory ability to hyaluronic acid.

[0097] 2. Soothing and Anti-inflammatory Effect Test

[0098] 1. Cell culture method

[0099] The cells were cultured in a constant temperature incubator at 30°C and 5% CO2. NIH3T3 and HaCaT cell lines were cultured in DMEM medium containing 10% fetal bovine serum, and RAW264.7 cell lines were cultured in 1640s medium containing 10% fetal bovine serum. All cell lines were cultured every day and passaged every other day. The inflammatory factor IL-6 was detected by real-time quantitative ELISA.

[0100] 2. ELISA test

[0101] (1) After the cells are treated, the cell culture medium is aspirated, centrifuged at 13500 rpm for 10 min, and the supernatant is collected and stored at -20°C for later use.

[0102] (2) Take a microplate and add 100 μL of cell culture sample, standard, and control into each microplate, with 3 replicates for each sample; seal the plate and incubate at room temperature for 2 h.

[0103] (3) LPS (100 mg / mL) was added to stimulate macrophages to produce inflammation, and the cells were cultured in an incubator for 24 hours. A control group without LPS was set up. The macrophages stimulated by LPS were respectively added with different concentrations of the jasmine functional components of compound examples 1, 2, and 3, and were placed in a cell incubator for further culture for 24 hours. At the same time, an LPS group without the functional components containing jasmine extracts of Examples 1-3 was set up as a negative control. After the experimental operation was performed according to the instructions of the ELISA kit, the OD values ​​were measured at 450 nm. The test results are shown in Table 3.

[0104] Table 3 Anti-inflammatory effects of different concentrations of active ingredients

[0105]

[0106] It can be seen from Table 3 that the greater the concentration of the active ingredient, the better the anti-inflammatory effect.

[0107] 3. Antibacterial effect test

[0108] The agar punching method was used to observe the inhibitory effect of the prepared moisturizing and antibacterial soft foot ointment on Trichophyton rubrum.

[0109] Pick a red Trichoderma colony about the size of a sesame seed, dissolve it in 1 mL of sterilized distilled water, mix it thoroughly, and adjust the turbidity of the bacterial suspension to (0.5-1) McFarland turbidity.

[0110] Use a 9cm diameter culture dish to take 20mL of the test object and melt it to make an SDA plate. Use a sterile glass coating rod to evenly spread 100μL of the bacterial suspension on the surface of the culture medium plate, cover it and place it on a clean bench at room temperature after incubation. Among them, there are 3 culture dishes for each strain of bacteria. When the surface of the plate is slightly dry, use a 7mm diameter puncher to punch 2 holes on the culture medium after the bacteria are applied. After picking out the agar in the hole, use a microsampler to absorb the 1g / mL water extract of purslane and add it to the hole. The liquid is flush with the edge of the hole and fully in contact with it. Do not let the liquid contaminate the agar plane outside the hole. There are 3 culture dishes for each water extract, a total of 6 culture dishes, placed at 28℃ for incubation. After 7 days, observe and measure the size of the antibacterial zone around each hole, and record its diameter. The diameter of the antibacterial zone of each hole is the number of its maximum and minimum diameters. The statistical results are shown in Table 4.

[0111] Table 4 Diameter of inhibition zone

[0112]

[0113] It can be seen from Table 4 that in the foot softening ointment of this scheme, the greater the concentration of the effective ingredients, the stronger the inhibitory effect on Trichophyton rubrum and the better the antibacterial effect.

[0114] The above experimental results show that the foot cream prepared by using the effective ingredients of jasmine extract in this scheme has good moisturizing, antibacterial and anti-inflammatory properties.

[0115] The above descriptions are only some embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Any equivalent device or equivalent process transformation made using the contents of the present invention specification, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A moisturizing and antibacterial foot cream containing jasmine extract, characterized in that: It includes the following raw materials in parts by weight: 10~25 parts of active ingredients; 60~75 parts of deionized water; 1.00-3.00 parts of sodium hyaluronate; Carbo U200.10~0.20 parts; 2.00~4.00 parts of butanediol; Glycerin 3.00~6.00 parts; 0.05~0.10 parts of disodium EDTA; Xanthan gum 0.10~0.50 parts; 1.00-2.00 parts of polydimethylsiloxane; 1.00-3.00 parts of polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer; Butylated hydroxytoluene 0.05~0.20 parts; Caprylic / capric triglyceride 1.00~4.00 parts; Polysorbate-80 0.20~0.80 parts; Jojoba seed oil 2.00~4.00 parts; 0.50-2.50 parts of cetostearyl alcohol; Cucumis sativus alcohol 0.50~2.00 parts; 0.20-0.40 parts of octanoylhydroxamic acid; Wherein, the effective ingredients include the following extract raw materials in parts by weight: Jasmine extract 23-27 parts; 18-22 parts of ivy extract; 18-22 parts of Sargassum extract; 8-10 parts of purslane extract; 0.8-1.2 parts of Pseudostellaria heterophylla extract; Among the functional ingredients, the preparation method of jasmine extract includes: The jasmine flowers are placed in a fragrance exhalation chamber with preset temperature, humidity and oxygen control parameters to release the fragrance. The jasmine fragrance released by the jasmine flowers is directionally captured in an activated carbon adsorption column by suction with a vacuum pump until the jasmine flowers wither and finish exhaling the fragrance. The activated carbon is then placed in an extraction tank for sealed vacuuming. A dimethyl ether extractant is also injected, and the extraction is performed at a temperature of 40.5°C and a solvent-to-solid ratio of 3.4:1 for 48 to 49 minutes. Finally, the extract is transferred to an evaporator for post-treatment, so that the dimethyl ether is gasified and separated, and jasmine essential oil, i.e., jasmine extract, is extracted. The jasmine essential oil is then encapsulated by a composite coacervation method to obtain jasmine essential oil microcapsules, i.e., microcapsules encapsulating the jasmine extract.

2. The moisturizing and antibacterial foot cream containing jasmine extract as claimed in claim 1, characterized in that: Among the effective ingredients, the ivy extract and the sargassum extract are mixed together and prepared by the following preparation method: According to the adding ratio of 18~22:18~22, ivy and Sargassum are washed, dried at 40℃, put into a grinder to be powdered, passed through a 100-mesh sieve and the undersize is obtained. Then, the undersize is extracted by hemicellulase-assisted extraction method with a solid-liquid ratio of 1:35, an extraction time of 1.5h, an extraction temperature of 70℃, and an enzyme concentration of 2.5% to obtain a mixed extract B1 containing ivy extract and Sargassum extract.

3. The moisturizing and antibacterial foot cream containing jasmine extract as claimed in claim 1, characterized in that: Among the effective ingredients, the preparation method of the purslane extract comprises: Purslane was subjected to ultrasonic extraction for 80 min at 65% ethanol concentration, solid-liquid ratio of 1:5, ultrasonic power of 360 W, and temperature of 70°C to obtain the purslane extract.

4. The moisturizing and antibacterial foot cream containing jasmine extract as claimed in claim 1, characterized in that: Among the effective ingredients, the preparation method of Pseudostellaria heterophylla extract includes: The Radix Pseudostellariae was crushed with a traditional Chinese medicine grinder and passed through a 40-mesh sieve to obtain material A1, which was then added to 40% ethanol by mass and subjected to microwave extraction for 30 min at a microwave temperature of 50°C and a power of 600 W. The precipitate was taken and the above steps were repeated once to obtain an extract B2 containing the Radix Pseudostellariae extract.

5. The method for preparing the moisturizing and antibacterial foot cream containing jasmine extract according to any one of claims 1 to 4, characterized in that: It includes: S01, mixing preset amounts of sodium hyaluronate, carbomer U20, butylene glycol, glycerin, disodium EDTA, xanthan gum, dimethicone, dimethicone / vinyl dimethicone crosspolymer, butylated hydroxytoluene, caprylic / capric triglyceride, polysorbate 80, jojoba seed oil, cetostearyl alcohol and deionized water at a preset temperature to obtain a mixed material A; S02, cooling the mixed material A to 40-45° C., then adding the functional ingredients and homogenizing at a low speed to obtain a mixed material B; S03. Mix cucumis alcohol and caprylhydroxamic acid with mixture B, stir until uniform, and prepare a foot softening ointment.

6. The method for preparing the moisturizing and antibacterial foot cream containing jasmine extract as claimed in claim 5, characterized in that: In S01, the components were mixed at 80°C.

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