A magnetic resonance compatible peripheral thermoelectric stimulation system and method

Abstract

The application discloses a kind of peripheral thermoelectric stimulation systems and methods compatible with magnetic resonance, including host computer in magnetic resonance control room, thermoelectric system control box and thermoelectric stimulation patch in magnetic resonance scanning room, the host computer is connected with thermoelectric system control box by communication system, and thermoelectric system control box and thermoelectric stimulation patch are electrically connected by electric signal lead wire and magnetic resonance compatible optical fiber, thermoelectric system control box is used to detect temperature, pressure on thermoelectric stimulation patch, and control matrix heat stimulation of thermoelectric stimulation patch, the host computer is parameter setting to thermoelectric system control box.The application provides a kind of thermoelectric stimulation system and method capable of efficient work under magnetic resonance environment, realizes flexible and accurate heat, electric stimulation under magnetic resonance condition, with temperature control function to improve use safety, solve the problems, such as low efficiency, poor controllability and low safety of heat stimulation mode under magnetic resonance environment.

Description

Technical Field

[0001] This invention belongs to the field of neurostimulation technology, specifically relating to a magnetic resonance-compatible peripheral thermoelectric stimulation system and method. Background Technology

[0002] Peripheral percutaneous thermal and electrical stimulation has been widely used in pain management and motor function rehabilitation. The evaluation of the regulatory effects of thermal and electrical stimulation on the human body and its mapping mechanism in the cerebral cortex have always been important research areas, and are of great significance for optimizing thermal and electrical stimulation techniques and exploring their mechanisms. With the development of technology, magnetic resonance imaging (MRI) has become an important technical tool in related research. For example, functional magnetic resonance imaging (fMRI) can provide high-resolution imaging of neuronal functional activity in the cerebral cortex, and has become an important tool for studying the detection of cerebral cortical activity under thermal and electrical stimulation.

[0003] However, due to the high magnetic field strength and gradient radio frequency field in the magnetic resonance imaging (MRI) environment, ordinary thermoelectric stimulators that work in normal environments cannot operate in the MRI chamber. Therefore, how to achieve thermoelectric stimulation in the MRI environment is a primary issue to consider in related research. In traditional methods, researchers often use hydrothermal stimulation for peripheral thermal stimulation, but this method has significant drawbacks. First, the temperature control precision and efficiency are low. Due to the low temperature in the MRI environment, it is difficult to maintain a constant temperature for hydrothermal stimulators during long-term experiments, and this can easily lead to burns to subjects. Second, it is difficult to determine the specific application site when using hydrothermal stimulation, making precise stimulation difficult. Moreover, traditional methods have poor adaptability to different parts of the human body and cannot provide targeted and efficient thermal stimulation at different temperatures and locations.

[0004] Therefore, a peripheral thermoelectric stimulation system that can operate normally in a magnetic resonance environment and is highly efficient, precise, controllable, and adaptable is of great significance for related research in this field. Summary of the Invention

[0005] To address the aforementioned technical problems, this invention provides a magnetic resonance-compatible peripheral thermoelectric stimulation system and method for thermal and electrical stimulation under magnetic resonance conditions. This system achieves flexible and precise thermal and electrical stimulation under magnetic resonance conditions, while also having a temperature control function to improve safety. It solves the problems of inefficiency, poor controllability, and low safety of thermal stimulation methods under magnetic resonance conditions.

[0006] To achieve the above objectives, the technical solution provided by the present invention is as follows:

[0007] A magnetic resonance-compatible peripheral thermoelectric stimulation system includes a host computer located in the magnetic resonance control room, a thermoelectric system control box located in the magnetic resonance scanning room, and a thermoelectric stimulation patch. The host computer is communicatively connected to the thermoelectric system control box via a communication system. The thermoelectric system control box and the thermoelectric stimulation patch are electrically connected via an electrical signal conductor and a magnetic resonance-compatible optical fiber. The thermoelectric system control box is used to detect the temperature and pressure on the thermoelectric stimulation patch and control the matrix-style thermal stimulation of the thermoelectric stimulation patch. The host computer sets parameters for the thermoelectric stimulation system control box.

[0008] Preferably, the thermoelectric stimulation patch includes an upper fabric and a lower fabric, as well as multiple temperature-sensing optical fibers, a pressure-sensitive array, a thermal stimulation array, and an electrical stimulation array located between the upper and lower fabrics.

[0009] Preferably, the pressure-sensitive array is a matrix composed of multiple piezoresistive pressure sensing units.

[0010] Preferably, the thermal stimulation array is an array composed of multiple heating liquid-heating wire module units. Each heating liquid-heating wire module unit includes a heating liquid module and a heating wire. The heating wire adopts an extended carbon fiber structure, with one end grounded, and uses carbon fiber material as its conductor.

[0011] Preferably, the electrical stimulation array consists of multiple electrical stimulation electrodes.

[0012] Preferably, the thermoelectric system control box includes

[0013] The laser generator, connected to the main control module, is used to emit pulsed laser light into the magnetic resonance-compatible fiber optic cable.

[0014] A distributed fiber optic temperature sensor, connected to the main control module, is used to collect optical signals in the magnetic resonance compatible fiber optic cable for real-time temperature detection and analysis of the magnetic resonance compatible thermoelectric stimulation patch.

[0015] The pressure sensor, connected to the main control module, is used to collect deformation information of the piezoresistive pressure sensing unit returned by the electrical signal lead wire, and to detect and analyze the pressure distribution on the magnetic resonance compatible thermoelectric stimulation patch in real time.

[0016] The temperature control module is connected to the main control module. Based on the control information provided by the main control module, it provides temperature control signals to the thermoelectric stimulation patch through the electrical signal lead wire to control the thermal stimulation of the thermoelectric stimulation patch.

[0017] The electrical stimulation module, connected to the main control module, is used to provide electrical stimulation signals to the thermoelectric stimulation patch through electrical signal leads based on the electrical stimulation information provided by the main control module, thereby realizing the electrical stimulation control of the thermoelectric stimulation patch.

[0018] The main control module collects temperature and pressure distribution information of the thermoelectric stimulation patch from distributed light temperature sensors and pressure sensors, designs specific temperature control parameters for the thermoelectric stimulation patch based on the provided distributed thermoelectric stimulation scheme, and transmits temperature control commands to the thermoelectric stimulation patch through the temperature control module.

[0019] The optoelectronic communication module, connected to the main control module, is used to receive control commands from the host computer and send the operating status parameters of the magnetic resonance compatible array-type adaptive peripheral thermoelectric stimulation system.

[0020] The magnetic shielding shell is used to ensure the normal operation of the internal control circuit of the thermoelectric system control box in the magnetic resonance environment, and to ensure that it does not affect magnetic resonance imaging.

[0021] The laser generator and distributed fiber optic temperature sensor are connected to the thermoelectric stimulation patch via magnetic resonance-compatible optical fiber, and the pressure sensor, temperature control module, and electrical stimulation module are connected to the thermoelectric stimulation patch via electrical signal lead wires.

[0022] A magnetic resonance-compatible peripheral thermoelectric stimulation method includes the following steps:

[0023] (1) Place the thermoelectric stimulation patch on the area to be stimulated, and connect the thermoelectric stimulation patch to the thermoelectric system control box through an electrical signal lead wire and a magnetic resonance compatible optical fiber.

[0024] (2) Connect the thermoelectric system control box to the host computer;

[0025] (3) Pressure is detected by the pressure-sensitive array mounted on the peripheral thermoelectric stimulation patch. The pressure signal is analyzed in the thermoelectric system control box to detect the contact pressure at various points of the stimulation patch.

[0026] (4) After the test is completed, disconnect the pressure sensor array measurement circuit to prevent the pressure sensor from forming a loop path, thereby avoiding large changes in magnetic flux and induced current.

[0027] (5) Based on the pressure information fed back by the pressure-sensitive array, analyze the fit between the thermoelectric stimulation patch and the subject. According to the experimental requirements, design the required thermoelectric stimulation paradigm through the thermoelectric system control box, and apply thermoelectric stimulation to the subject after the experiment begins.

[0028] (6) Temperature changes are detected by distributed fiber optic temperature sensors, and the stimulation mode is adjusted in real time based on temperature feedback.

[0029] The beneficial effects of this invention are:

[0030] 1. The magnetic resonance-compatible array-type adaptive thermoelectric stimulation system of the present invention can be used in a magnetic resonance scanning chamber and is more convenient to operate than traditional methods.

[0031] 2. This invention realizes array-type temperature sensing, pressure sensing and array-type thermal stimulation, improves adaptability to different stimulation sites and different body postures, prevents excessive heat from affecting the ambient temperature, and improves energy saving and environmental protection capabilities.

[0032] 3. The array-type temperature sensing, pressure sensing, and array-type thermal stimulation of this invention can provide targeted and coded thermoelectric stimulation for the stimulation object, thus providing a more flexible and variable stimulation mode to adapt to the requirements of different experiments.

[0033] 4. This invention uses a heating wire-heating liquid structure to form a thermal stimulation module, and is equipped with temperature control feedback, which effectively prevents the skin from being burned by excessive temperature and improves heat dissipation efficiency.

[0034] 5. The magnetic resonance-compatible array-type adaptive thermoelectric stimulation system of this invention has higher practicality and reliability in installation, use, and maintenance, effectively supports thermal pain stimulation experiments, and is of great significance for in-depth research on scientific issues. Attached Figure Description

[0035] Figure 1 This is a system block diagram of the present invention;

[0036] Figure 2 This is a schematic diagram of the shielding of various parts of the present invention;

[0037] Figure 3 This is a schematic diagram of the modules inside the thermoelectric system control box in this invention;

[0038] Figure 4 This is a schematic diagram of the side cross-sectional structure of the thermoelectric stimulation patch in this invention;

[0039] Figure 5 This is a schematic diagram of the thermal stimulation array in this invention;

[0040] Figure 6 This is a schematic diagram of the temperature-sensing optical fiber and pressure-sensing array in this invention;

[0041] Figure 7 This is a schematic diagram of the electrical stimulation array in this invention;

[0042] Figure 8 This is a schematic diagram illustrating a practical application scenario of the present invention;

[0043] Figure 9 This is a schematic diagram illustrating a second practical application scenario of the present invention;

[0044] Figure 10 This is a schematic diagram illustrating the third practical application scenario of the present invention;

[0045] Figure 11 This is a schematic diagram illustrating the fourth practical application scenario of the present invention;

[0046] Explanation of annotations in the diagram

[0047] 1. Host computer; 2. Thermoelectric system control box; 3. Electrical signal lead wire; 4. Magnetic resonance compatible fiber optic cable; 5. Thermoelectric stimulation patch; 6. Carbon fiber shielding mesh; 7. Non-magnetic metal foil; 21. Power supply module; 22. Laser generator; 23. Distributed fiber optic temperature sensor; 24. Pressure sensor; 25. Main control module; 26. Temperature control module; 27. Electrical stimulation module; 28. Optoelectronic communication module; 29. ​​Magnetic shielding shell; 51. Upper fabric; 52. Lower fabric; 53. Temperature measuring fiber optic cable; 54. Pressure sensing array; 55. Thermal stimulation array; 56. Electrical stimulation array; 551. Heating liquid module; 552. Heating wire. Detailed Implementation

[0048] To further understand the content of this invention, the invention will be described in detail with reference to the embodiments. The following embodiments are used to illustrate the invention, but are not intended to limit the scope of the invention.

[0049] Example 1

[0050] like Figure 1 As shown, this embodiment relates to a magnetic resonance-compatible peripheral thermoelectric stimulation system, which includes a host computer 1 located in the magnetic resonance control room, a thermoelectric system control box 2 located in the magnetic resonance scanning room, and a thermoelectric stimulation patch 5. The host computer 1 is connected to the thermoelectric system control box 2 via a communication system. The thermoelectric system control box 2 and the thermoelectric stimulation patch 5 are electrically connected via an electrical signal lead wire 3 and a magnetic resonance-compatible optical fiber 4. The thermoelectric system control box 2 is used to detect the temperature and pressure on the thermoelectric stimulation patch 5 and control the matrix-style thermal stimulation of the thermoelectric stimulation patch. The host computer 1 adjusts and sets the parameters of the thermoelectric stimulation system control box 2.

[0051] The host computer 1 mainly consists of a control room computer and a USB-to-photoelectric conversion box. The communication system is connected to the thermoelectric system control box 2 via optical fiber.

[0052] The thermoelectric system control box 2 is connected to the thermoelectric stimulation patch 5 via the electrical signal lead wire 3 and the magnetic resonance compatible optical fiber 4. It can analyze the real-time temperature and pressure of the thermoelectric stimulation patch 5 transmitted by the electrical signal lead wire 3 and the magnetic resonance compatible optical fiber 4 and transmit it to the host computer 1. According to the built-in program and the instructions of the host computer 1, it sends thermoelectric control commands to the thermoelectric stimulation patch 5, thereby realizing temperature regulation and electrical stimulation.

[0053] like Figure 4As shown, the thermoelectric stimulation patch 5 includes an upper fabric 51 and a lower fabric 52, as well as multiple temperature-sensing optical fibers 53, a pressure-sensitive array 54, a thermal stimulation array 55, and an electrical stimulation array 56 located between the upper fabric 51 and the lower fabric 52. The pressure-sensitive array 54 is a matrix composed of multiple piezoresistive pressure sensing units. The thermal stimulation array 55 is a matrix composed of multiple heating liquid-heating wire module units, each including a heating liquid module 551 and a heating wire 552. The heating wire employs an extended carbon fiber structure, with one end grounded, and uses carbon fiber material as its conductor. The electrical stimulation array 56 consists of multiple electrical stimulation electrodes. The multiple temperature-sensing optical fibers 53 are used to conduct the thermal radiation on the thermoelectric stimulation patch 5, and the pressure-sensing array 54 is used to measure and conduct the pressure distribution on the thermoelectric stimulation patch 5. The piezoresistive pressure sensing units are generally designed using piezoresistive single-crystal silicon. The heating liquid-heating wire module units in the thermal stimulation array 55 can be heated individually. The electrical stimulation array 56 is used to provide electrical stimulation to specific sites based on the electrical stimulation signal emitted by the thermoelectric system control box 2. The upper fabric 51 and the lower fabric 52 are used to form the specific structure of the thermoelectric stimulation patch 5, fix the internal components, provide adhesion, and provide a more comfortable feel for the experimental subject. The upper fabric 10 is filled with conductive gel for the electrical stimulation array.

[0054] The structure and connection relationships of each module in the thermoelectric system control box 2 are as follows: Figure 3As shown, the power supply module 21 is responsible for supplying power to each component; the laser generator 22 is responsible for emitting pulsed lasers with a duration of 10 ns to the magnetic resonance compatible fiber optic cable 4; the distributed fiber optic temperature sensor 23 is responsible for collecting the scattered light from Rayleigh scattering in the magnetic resonance compatible fiber optic cable 4, processing the optical signal, analyzing the temperature distribution in the optical path of the magnetic resonance compatible fiber optic cable 4, realizing real-time temperature detection and analysis of the thermoelectric stimulation patch 5, and feeding the detection results back to the main control module 25; the pressure sensor 24 is responsible for collecting the deformation information of the piezoresistive pressure sensing unit returned by the electrical signal lead wire 3, converting it into an electrical signal, thereby realizing real-time detection and analysis of the pressure distribution on the thermoelectric stimulation patch 5, and feeding it back to the main control module 25; the temperature control module 26 is responsible for controlling the temperature according to the control provided by the main control module 25. The main control module 25 provides temperature control information to the thermoelectric stimulation patch 5 via the electrical signal lead line 3, thereby achieving specific temperature regulation. The electrical stimulation module 27, based on the electrical stimulation information provided by the main control module 25, provides electrical stimulation signals to the thermoelectric stimulation patch 5 via the electrical signal lead line 3, achieving electrical stimulation control of the thermoelectric stimulation patch 5. The main control module 25 can interact with the communication system via optical fiber, collecting temperature and pressure distribution information of the thermoelectric stimulation patch 5 from the distributed light temperature sensor 23 and pressure sensor 24. Based on the provided distributed thermoelectric stimulation scheme and instructions from the host computer 1, it designs specific temperature control parameters for the thermoelectric stimulation patch 5 and transmits temperature control instructions to the thermoelectric stimulation patch 5 via the temperature control module 26. The optoelectronic communication module 28 receives control commands from the host computer 1 and sends system operating status parameters. The magnetic shielding shell 29 ensures the normal operation of the internal control circuit of the thermoelectric system control box 2 in the magnetic resonance environment, ensuring that the thermoelectric system control box 2 does not cause excessive changes in the static magnetic field density, thus not affecting magnetic resonance imaging.

[0055] The magnetic shielding scheme in this embodiment is as follows: Figure 2 As shown, the thermoelectric system control box 2 is encased in a magnetically shielded shell 29, and the electrical signal lead wire 3 is wrapped in a carbon fiber shielding mesh 6. The thermoelectric system control box 2 and the electrical signal lead wire 3 are connected, and their interface is wrapped in a non-magnetic metal foil 7. The electrical signal lead wire 3 is connected to the thermoelectric stimulation patch 5, and its interface is also wrapped in a non-magnetic metal foil 7. The magnetic resonance compatible fiber optic cable 4 uses a non-metallic material for its interface design, and the electrical signal lead wire 3 is made of twisted and wound carbon fiber wire.

[0056] The magnetic shielding shell, non-magnetic metal foil, and carbon fiber shielding mesh are made of non-magnetic conductors with relative magnetic permeability close to that of air. When they enter the MRI scanning chamber, they are in a high static magnetic field environment. Because their relative magnetic permeability is close to that of air, the static magnetic field density does not change significantly, thus not affecting MRI imaging. During MRI, the gradient magnetic field changes, and the conductors generate an induced electric field. The magnetic field generated by this induced electric field cancels out the gradient magnetic field. Therefore, the interior of the magnetic shielding shell, non-magnetic metal foil, and carbon fiber shielding mesh is unaffected by the gradient magnetic field.

[0057] Before magnetic resonance imaging (MRI), the pressure-sensitive array 54 scans the attachment site and body posture, and, combined with pre-set thermal stimulation requirements, determines the area requiring array thermal stimulation. Then, the connections of each node in the pressure matrix are disconnected to create an open circuit. Therefore, the pressure detection module will not form a loop in the MRI device, thus preventing large changes in magnetic flux and induced current. Since the temperature sensor uses fiber optic detection, and the fiber optic cable and its interface do not contain any metal components, it will not form a loop in the MRI device, thus preventing large changes in magnetic flux and induced current. The heating wire in the thermoelectric stimulation area uses an extended carbon fiber structure, which also does not generate large induced current during MRI. Therefore, the thermal stimulation area is unaffected by MRI and will not significantly impact the imaging process. During MRI, the electromagnetic field in the imaging area changes rapidly. The electrical stimulation electrodes are designed with carbon fiber material, and the carbon fiber electrode wires are twisted and wound together and fixed with non-magnetic metal foil, preventing the formation of a loop path and thus preventing large changes in magnetic flux and induced current.

[0058] During the operation of this invention, multiple temperature-measuring optical fibers 53 and a pressure-sensing array 54 located on the thermoelectric stimulation patch 5 measure temperature and pressure and transmit them to the thermoelectric system control box 2. A schematic diagram of the optical path and wiring for temperature and pressure detection is shown below. Figure 6 As shown, the dashed line represents the temperature-measuring optical path. During this process, the pulsed laser in the thermoelectric system control box 2 emits a pulsed laser beam through the magnetic resonance-compatible fiber 4 into the optical fiber in the thermoelectric stimulation patch 5. The pulsed laser undergoes Rayleigh scattering in the fiber, and the wavelength and frequency of this scattering change according to the temperature at the location of the fiber. Therefore, the distributed light temperature sensor 23 in the thermoelectric system control box 2 decodes the reflected light to obtain the temperature distribution in this optical path. During the deformation of the piezoresistive pressure sensing unit 12, its volume resistance changes according to the magnitude of the deformation. By scanning the resistance change of the pressure-sensitive array 54, the pressure change on the pressure-sensitive array 54 in the thermoelectric stimulation patch 5 can be obtained. Before the magnetic resonance imaging begins, the system scans the attachment status of the stimulation patch at the desired stimulation site. Combined with the pre-set stimulation settings, the thermoelectric stimulation zone is determined, and the pressure scanning line and its nodes are disconnected to prevent loop formation. Afterward, the temperature change in the thermal stimulation zone is monitored in real time through the temperature-measuring optical path. Figure 7 As shown, the electrical stimulation array 56 in the thermoelectric stimulation patch 5 is embedded in the thermoelectric stimulation patch in a sparse arrangement. It is designed with a structure of carbon fiber electrodes combined with conductive gel and contacts the subject's skin through openings on the upper fabric 51.

[0059] During use, the temperature change of the thermal stimulation zone is monitored in real time. The desired stimulation area is stimulated by an array of heating liquid-heating wire units. The heating wire and its surrounding leads are made of carbon fiber to avoid generating induced current. The heating liquid is made of pure water to avoid generating induced eddy current in the liquid. Figure 4 In the diagram, the heating liquid module 551 is designed with rigid materials, and the dashed line represents the liquid level. This module undergoes vacuum treatment to increase the internal pressure difference, thereby lowering the boiling point of the heating liquid. The heating wire 552 is embedded in the liquid of the heating liquid module 551 through a heat transfer material to improve the heating effect. Matrix control is used to improve control efficiency; the matrix structure is shown below. Figure 5 The diagram illustrates the use of magnetic resonance-compatible semiconductor transistors for switching design, and the conversion of serial control signals into parallel control signals via a shift register to achieve matrix control.

[0060] Example 2

[0061] like Figure 8 As shown, this embodiment relates to a typical example of a magnetic resonance-compatible peripheral thermoelectric stimulation system, comprising five parts: a host computer 1 for interactive operation located in the magnetic resonance control room; a thermoelectric system control box 2 located in the magnetic resonance scanning room; electrical signal lead wires 3; a magnetic resonance-compatible optical fiber 4; and a magnetic resonance-compatible thermoelectric stimulation patch 5. The magnetic resonance-compatible thermoelectric stimulation patch 5 is fixed in place and collects pressure and temperature information, which is fed back to the thermoelectric system control box 2 via the electrical signal lead wires 3 and the magnetic resonance-compatible optical fiber 4. The host computer 1 sets and adjusts the stimulation paradigm of the thermoelectric system control box 2, and the thermoelectric system control box 2 implements the stimulation paradigm and settings of the thermoelectric stimulation patch 5 through the magnetic signal lead wires 3.

[0062] Example 3

[0063] like Figure 9 As shown, the magnetic resonance-compatible peripheral thermoelectric stimulation system and method of the present invention can operate independently of the host computer and its communication system 1. The thermoelectric system control box 2 has a built-in temperature distribution algorithm that can adaptively adjust the working state of the thermoelectric stimulation matrix based on the feedback from the temperature measuring fiber and the pressure sensing matrix.

[0064] Example 4

[0065] like Figure 10As shown, this embodiment relates to a magnetic resonance-compatible peripheral thermoelectric stimulation system capable of targeted adjustments to the desired stimulation site and shape. The figure illustrates a magnetic resonance-compatible sleeve-type thermoelectric stimulation system designed for the subject's upper arm according to experimental requirements. This embodiment is merely an explanation and illustration of the method described in this invention; the method can also be applied to other sites and does not limit the application scenarios of this invention.

[0066] Example 5

[0067] like Figure 11 As shown, this embodiment relates to a magnetic resonance-compatible peripheral thermoelectric stimulation system capable of targeted adjustments for different stimulation subjects and their body shapes and postures. The figure illustrates a magnetic resonance-compatible thermoelectric stimulation patch system designed for rats according to experimental requirements. This embodiment is merely an explanation and illustration of the method described in this invention; the method can also be used to provide thermal pain stimulation to other experimental subjects and does not limit the application scenarios of this invention.

[0068] Although preferred embodiments of the present invention have been described above in conjunction with examples, the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art, under the guidance of the present invention, can make many other modifications without departing from the spirit and scope of the claims, such as considering the randomness of soil parameters, considering the randomness of the necking length, or considering different or more safety parameters. These all fall within the scope of protection of the present invention.

[0069] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A magnetic resonance-compatible peripheral thermoelectric stimulation system, characterized in that, It includes a host computer located in the magnetic resonance control room, a thermoelectric system control box located in the magnetic resonance scanning room, and a thermoelectric stimulation patch. The host computer is connected to the thermoelectric system control box via a communication system. The thermoelectric system control box and the thermoelectric stimulation patch are electrically connected via an electrical signal lead wire and a magnetic resonance compatible optical fiber. The thermoelectric system control box is used to detect the temperature and pressure on the thermoelectric stimulation patch and control the matrix thermal stimulation of the thermoelectric stimulation patch. The host computer sets the parameters of the thermoelectric stimulation system control box. The thermoelectric stimulation patch includes an upper fabric and a lower fabric, as well as multiple temperature-sensing optical fibers, a pressure-sensitive array, a thermal stimulation array, and an electrical stimulation array located between the upper and lower fabrics. After the pressure detection is completed, the pressure-sensitive array measurement circuit is disconnected. The thermal stimulation array is a matrix composed of multiple heating liquid-heating wire module units. Each heating liquid-heating wire module unit includes a heating liquid module and a heating wire. The heating wire adopts an extended carbon fiber structure, with one end grounded and carbon fiber material used as its conductor. The external surface of the electrical signal lead wire is wrapped with a carbon fiber shielding mesh. The interfaces connecting the thermoelectric system control box and the electrical signal lead wire, as well as the interfaces connecting the electrical signal lead wire and the thermoelectric stimulation patch, are all wrapped with non-magnetic metal foil. The magnetic resonance compatible optical fiber uses a non-metallic material interface.

2. The magnetic resonance-compatible peripheral thermoelectric stimulation system according to claim 1, characterized in that, The pressure-sensitive array is a matrix composed of multiple piezoresistive pressure sensing units.

3. The magnetic resonance-compatible peripheral thermoelectric stimulation system according to claim 1, characterized in that, The described electrical stimulation array consists of multiple electrical stimulation electrodes.

4. The magnetic resonance-compatible peripheral thermoelectric stimulation system according to claim 1, characterized in that, The thermoelectric system control box includes: A laser generator, connected to the main control module, is used to emit pulsed laser light into the magnetic resonance-compatible fiber optic cable; a distributed fiber optic temperature sensor, also connected to the main control module, is used to collect optical signals from the magnetic resonance-compatible fiber optic cable for real-time temperature detection and analysis of the magnetic resonance-compatible thermoelectric stimulation patch; and a pressure sensor, also connected to the main control module, is used to collect deformation information of the piezoresistive pressure sensing unit returned by the electrical signal lead wire for real-time detection and analysis of the pressure distribution on the magnetic resonance-compatible thermoelectric stimulation patch. The temperature control module is connected to the main control module. Based on the control information provided by the main control module, it provides temperature control signals to the thermoelectric stimulation patch through the electrical signal lead wire to control the thermal stimulation of the thermoelectric stimulation patch. The electrical stimulation module, connected to the main control module, is used to provide electrical stimulation signals to the thermoelectric stimulation patch through electrical signal leads based on the electrical stimulation information provided by the main control module, thereby realizing the electrical stimulation control of the thermoelectric stimulation patch. The main control module collects temperature and pressure distribution information of the thermoelectric stimulation patch from distributed light and temperature sensors and pressure sensors. Based on the provided distributed thermoelectric stimulation scheme, it designs specific temperature control parameters for the thermoelectric stimulation patch and transmits temperature control commands to the thermoelectric stimulation patch through the temperature control module. The optoelectronic communication module, connected to the main control module, is used to receive control commands from the host computer and send the operating status parameters of the magnetic resonance compatible array-type adaptive peripheral thermoelectric stimulation system. The magnetic shielding shell is used to ensure the normal operation of the internal control circuit of the thermoelectric system control box in the magnetic resonance environment, and to ensure that it does not affect magnetic resonance imaging. The laser generator and distributed fiber optic temperature sensor are connected to the thermoelectric stimulation patch via magnetic resonance-compatible optical fiber, and the pressure sensor, temperature control module, and electrical stimulation module are connected to the thermoelectric stimulation patch via electrical signal lead wires.

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