A device for extracting and preparing heparin sodium without salt

Abstract

The application discloses a device for preparing heparin sodium without salt extraction, which comprises a preparation cylinder, a vertical rotating sleeve is arranged in the preparation cylinder, an arc-shaped tube is rotationally connected to the outer peripheral wall of the vertical rotating sleeve through a supporting tube, a magnetic supporting body is arranged on the outer wall of the arc-shaped tube close to the bottom of one end, a hanging shaft is arranged in the vertical rotating sleeve and can slide up and down, a filter screen plate is arranged at the bottom of the hanging shaft, an annular electromagnetic plate is fixedly connected to the outer periphery of the filter screen plate and is in sealing sliding connection with the inner wall of the preparation cylinder, and the annular electromagnetic plate is located below the magnetic supporting body. In the application, the arc-shaped tube is arranged in the preparation cylinder and can rotate and swing up and down, when the arc-shaped tube moves, the exchange resin accumulated above the filter screen plate in the preparation cylinder is drained and dispersed upward, so that the heparin sodium pretreatment liquid and the exchange resin are fully contacted, and the ion exchange efficiency is improved.

Description

Technical Field

[0001] This invention relates to the field of heparin sodium preparation technology, and more particularly to a salt-free extraction and preparation apparatus for heparin sodium. Background Technology

[0002] Heparin sodium interferes with many aspects of the blood clotting process and has anticoagulant effects both in vivo and in vitro. Its mechanism of action is complex, primarily through binding to antithrombin III (AT-III), thereby enhancing the latter's inhibitory effect on activated coagulation factors II, IX, X, XI, and XII. The consequences include preventing platelet aggregation and destruction, hindering the formation of thromboplastin-activating enzymes, preventing the conversion of prothrombin to thrombin, and inhibiting thrombin, thus preventing fibrinogen from converting into fibrin, thereby exerting its anticoagulant effect.

[0003] Traditional heparin sodium extraction methods primarily employed salting-out, which generates large amounts of high-salt wastewater. Therefore, current common extraction methods utilize salt-free extraction. Salt-free extraction involves adsorption and elution processes. The adsorption process primarily utilizes a mixture of ion exchange resin and heparin sodium pretreatment solution to achieve ion exchange and complete the adsorption treatment. In the elution process, the adsorption-treated ion exchange resin is mixed with the eluent to prepare the eluent, which is then further processed to complete the preparation of heparin sodium. However, the adsorption and elution processes are prone to problems such as low exchange and elution efficiency and filter clogging, which in turn affects the preparation efficiency. Noise... The noise level is high, resulting in significant noise pollution. Analysis revealed the following reasons: 1. The ion exchange resin is prone to deposition, making it difficult to fully contact the pretreatment liquid, thus leading to low adsorption and exchange efficiency. Therefore, a stirring device is usually installed inside the preparation chamber. However, the stirring device easily damages the ion exchange resin, and the broken resin can clog the filter screen used to discharge the pretreatment liquid, affecting normal liquid discharge. 2. Electric equipment, such as electric motors, is typically used during adsorption and elution. Since the adsorption and rinsing cycle is relatively long, usually around 8 hours, prolonged operation not only generates a large amount of heat but also produces continuous noise pollution. Summary of the Invention

[0004] The purpose of this invention is to solve the problems of low preparation efficiency, easy clogging of filter plates and high noise pollution in existing preparation equipment during adsorption exchange and elution processes, and to propose a salt-free extraction and preparation device for heparin sodium.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A salt-free extraction and preparation apparatus for heparin sodium includes a preparation cylinder. A vertical rotating sleeve is disposed within the preparation cylinder. An arc-shaped tube is rotatably connected to the outer periphery of the vertical rotating sleeve via a support. A magnetic support is disposed on the outer wall of the arc-shaped tube near one end of its bottom. A hanging shaft is slidably disposed vertically within the vertical rotating sleeve. A filter plate is disposed at the bottom of the hanging shaft. An annular electromagnetic plate is fixedly connected to the outer periphery of the filter plate and slidably sealed to the inner wall of the preparation cylinder. The annular electromagnetic plate is located below the magnetic support. A heat-insulated circulating power water tank is fitted onto the outer wall of the preparation cylinder. A flow pipe communicating with the inner cavity is disposed on the outer periphery of the heat-insulated circulating power water tank. A transmission mechanism is disposed on the heat-insulated circulating power water tank for driving the vertical rotating sleeve to rotate and the hanging shaft to slide vertically back and forth.

[0006] As a further description of the above technical solution: The arc center of the arc tube coincides with the axis of the vertical rotating sleeve. The inner arc wall of the arc tube is fixedly connected to a positioning tube that is rotatably connected to the support tube. The middle part of the filter plate is fixedly connected to a positioning sleeve that is rotatably connected to the bottom of the hanging shaft.

[0007] As a further description of the above technical solution: The transmission mechanism includes an annular transmission disc, a gantry frame, a connecting rod, and a peak-valley annular track disc. The annular transmission disc is located on the top of the insulated circulating power water tank, and the peak-valley annular track disc is located inside the insulated circulating power water tank. Two columns on the gantry frame pass through the annular transmission disc and their bottoms roll in cooperation with the peak-valley annular track disc. The top of the vertical rotating sleeve passes through the preparation cylinder and is fixedly connected to one end of the connecting rod. The other end of the connecting rod is fixedly connected to a sliding sleeve sleeved on the column. The top of the hanging shaft is fixedly connected to the top of the gantry frame.

[0008] As a further description of the above technical solution: The flow tube and the outer peripheral wall of the preparation cylinder are tangentially connected, and the lower end face of the annular transmission disc is fixedly connected to a blade that extends into the heat-insulating circulating power water tank.

[0009] As a further description of the above technical solution: The top of the insulated circulating power water tank is provided with an annular connecting hole, and the annular transmission disc is sleeved in the annular connecting hole and is rotatably connected.

[0010] As a further description of the above technical solution: The vertical rotating sleeve has an annular cavity that communicates with the support tube. The arc-shaped tube communicates with the support tube through a positioning tube. The top of the vertical rotating sleeve is fixedly connected to an elution tube.

[0011] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: 1. In this invention, an arc-shaped bend with rotational and vertical swinging motion is set inside the preparation cylinder. When the arc-shaped bend moves, it will guide and disperse the exchange resin accumulated above the filter plate inside the preparation cylinder upward, so that the heparin sodium pretreatment solution and the exchange resin are in full contact, thereby improving the efficiency of ion exchange.

[0012] 2. In this invention, the preparation cylinder is equipped with an arc-shaped bend and a magnetic support and an electromagnetic plate for controlling the up-and-down swing of the arc-shaped bend. This arrangement greatly simplifies the structure for improving ion exchange efficiency, does not affect the flowability of the exchange resin particles, will not cut or squeeze and damage the exchange resin, and will not clog the filter plate. It has the advantages of simple structure and low cost.

[0013] 3. In this invention, a heat-insulating circulating power water tank is set outside the preparation cylinder. The heat-insulating circulating power water tank provides a stable exchange temperature to the preparation cylinder from the outside, so that the ion exchange between the exchange resin and the heparin sodium pretreatment solution is more thorough.

[0014] 4. In this invention, a transmission mechanism is provided on the heat-insulated circulating power water tank to drive the arc-shaped tube to rotate. The outer wall of the heat-insulated circulating power water tank is provided with a flow pipe. When water flows through the flow pipe, the arc-shaped tube rotates. No electrical control equipment is required, which greatly reduces the noise of the preparation process. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of a salt-free extraction and preparation device for heparin sodium proposed in this invention; Figure 2 This is a schematic diagram of the structure of the preparation cylinder, vertical rotating sleeve, hanging shaft, filter plate, arc tube, magnetic support body and electromagnetic plate of the heparin sodium salt-free extraction and preparation device proposed in this invention; Figure 3 This is a schematic diagram of the structure of the insulated circulating power water tank of the heparin sodium salt-free extraction and preparation device proposed in this invention; Figure 4 This is a schematic diagram of the transmission mechanism of a salt-free extraction and preparation device for heparin sodium proposed in this invention; Figure 5 This is a vertical rotating cross-sectional view of a salt-free extraction and preparation apparatus for heparin sodium proposed in this invention.

[0016] Legend: 1. Preparation cylinder; 2. Vertical rotating sleeve; 21. Support sleeve; 22. Annular cavity; 23. Eluting tube; 3. Arc-shaped tube; 31. Positioning tube; 4. Magnetic support body; 5. Hanging shaft; 6. Filter screen plate; 61. Positioning sleeve; 7. Annular electromagnetic plate; 8. Insulated circulating power water tank; 81. Flow pipe; 82. Transmission mechanism; 821. Annular transmission disc; 8211. Blade plate; 822. Portal frame; 8221. Column; 823. Connecting rod; 8231. Sliding sleeve; 824. Peak-valley annular trajectory disc. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example

[0018] Please see Figure 1-4A salt-free extraction and preparation apparatus for heparin sodium includes a preparation cylinder 1. A feed pipe is installed at the top of the preparation cylinder 1, through which heparin sodium pretreatment solution and exchange resin are injected into the preparation cylinder 1. A discharge pipe is installed at the bottom of the preparation cylinder 1, serving to discharge the liquid. A vertical rotating sleeve 2 is installed inside the preparation cylinder 1. An arc-shaped tube 3 is rotatably connected to the outer peripheral wall of the vertical rotating sleeve 2 via a support 21. The arc-shaped tube 3 has openings at both ends. Preferably, the arc center of the arc-shaped tube 3 coincides with the axis of the vertical rotating sleeve 2. A positioning tube 31, rotatably connected to the support 21, is fixedly connected to the inner arc wall of the arc-shaped tube 3. A magnetic support 4, which is a permanent magnet, is installed near the bottom of one end of the outer wall of the arc-shaped tube 3. A hanging shaft 5 is slidably installed inside the vertical rotating sleeve 2. The bottom of the hanging shaft 5 is... A filter plate 6 is provided, specifically, a positioning sleeve 61 is fixedly connected to the middle of the filter plate 6 and rotatably connected to the bottom of the hanging shaft 5. An annular electromagnetic plate 7 is fixedly connected to the outer periphery of the filter plate 6 and slidably sealed to the inner wall of the preparation cylinder 1. The aforementioned ion exchange resin particles will fall onto the filter plate 6 and the annular electromagnetic plate 7. The annular electromagnetic plate 7 is located below the magnetic support 4. An electromagnetic coil is provided inside the annular electromagnetic plate 7. When energized, it will generate a repulsive force against the magnetic support 4. The magnetic support 4 uses its own weight to drive one end of the arc tube 3 to tilt downward and approach the annular electromagnetic plate 7. Since the ion exchange resin particles tend to deposit at the bottom of the pretreatment liquid, when the vertical rotating sleeve 2 rotates, the arc tube 3 will guide the resin particles at the bottom upward. After being guided, the sprayed resin particles and pretreatment liquid will... Comprehensive contact significantly improves the efficiency of heparin sodium ion exchange. During the rotation of the vertical rotating sleeve 2, the lifting shaft 5 moves up and down, causing the arc-shaped tube 3 to swing up and down under the push of the annular electromagnetic plate 7. During this swing, the arc-shaped tube 3 draws resin particles from different positions on the annular electromagnetic plate 7 upwards, resulting in complete dispersion of the resin particles. It is important to note that the arc-shaped tube 3 and other structures used to enhance the ion exchange rate inside the preparation cylinder 1 are simple in design. This simplicity not only does not affect the fluidity of the resin particles and prevents damage to them, but also results in a simple structure and low manufacturing cost. The outer wall of the preparation cylinder 1 is fitted with a heat-insulated circulating power water tank 8, which provides a stable exchange temperature to the preparation cylinder 1, ensuring that the temperature of the pretreatment solution inside the preparation cylinder 1 remains stable at 25°C. Within a temperature range of -30 degrees Celsius, the ion exchange efficiency is relatively high. The outer peripheral wall of the insulated circulating power water tank 8 is equipped with a flow pipe 81 connecting to the inner cavity. The flow pipe 81 connects to an external circulating water circuit, ensuring a constant water temperature within the insulated circulating power water tank 8. The insulated circulating power water tank 8 also functions to drive the rotation of the vertical rotating sleeve 2 and the reciprocating sliding of the hanging shaft 5. Specifically, the insulated circulating power water tank 8 is equipped with a transmission mechanism 82 for driving the rotation of the vertical rotating sleeve 2 and the reciprocating sliding of the hanging shaft 5. This design replaces the electrically controlled drive structure, reducing drive noise. Specifically, the transmission mechanism 82 includes an annular transmission disc 821, a gantry frame 822, a connecting rod 823, and a peak-valley annular track disc 824.An annular transmission disc 821 is mounted on top of the insulated circulating power water tank 8. Specifically, the top of the insulated circulating power water tank 8 has an annular connecting hole, and the annular transmission disc 821 is fitted inside the annular connecting hole and is rotatably connected. A peak-valley annular track disc 824 is mounted inside the insulated circulating power water tank 8. Two columns 8221 on the portal frame 822 pass through the annular transmission disc 821 and their bottoms roll in cooperation with the peak-valley annular track disc 824. Specifically, rollers are provided at the bottom of the columns 8221 that contact the upper surface of the peak-valley annular track disc 824. The peak-valley annular track disc 824 has a slope located between the peaks and valleys. When the columns 8221 roll along the peak-valley annular track disc 824, they move up and down. The top of the vertical rotating sleeve 2 passes through the preparation cylinder 1 and is fixedly connected to one end of the connecting rod 823. The other end of the connecting rod 823 is fixedly connected to a sleeve mounted on the column 8221. The top of the sliding sleeve 8231, the top of the hanging shaft 5, and the top of the portal frame 822 are fixedly connected. When the annular transmission disc 821 rotates, the column 8221 moves up and down under the action of the peak-valley annular track disc 824, thereby driving the hanging shaft 5 to move up and down. At the same time, under the action of the connecting rod 823, the vertical rotating sleeve 2 rotates. The flow pipe 81 is tangentially connected to the outer peripheral wall of the preparation cylinder 1. The lower end face of the annular transmission disc 821 is fixedly connected to a blade 8211 that extends into the insulated circulating power water tank 8. The flow pipe 81 is connected in series to an external constant temperature circulating water pipeline. When water flows through the flow pipe 81, part of the water flows directly through the flow pipe 81, and part of it enters the insulated circulating power water tank 8 and undergoes vortex motion. The vortex water flow pushes the blade 8211, thereby driving the rotation of the annular transmission disc 821. This power method greatly reduces the noise of the preparation device. Example

[0019] Please see Figure 2 and Figure 5 The difference from Example 1 is that the vertical rotating sleeve 2 has an annular cavity 22 that communicates with the support tube 21. The arc-shaped tube 3 is connected to the support tube 21 through the positioning tube 31. The top of the vertical rotating sleeve 2 is fixedly connected to the elution tube 23. The external elution liquid is pressurized and injected into the preparation cylinder 1 through the elution tube 23. During the injection process, the elution liquid is sprayed upward and downward from the inclined arc-shaped tube 3. The sprayed elution liquid impacts the resin rubber, which greatly improves the elution intensity and makes the elution more comprehensive.

[0020] Working Principle: In use, when ion exchange is required between heparin sodium pretreatment solution and ion exchange resin, both are introduced into the preparation cylinder 1. At this time, a constant-temperature water body flows through the flow pipe 81. The water impacts the blade plate 8211, causing the annular transmission disc 821 to rotate. The gantry frame 822 rotates accordingly, and under the action of the connecting rod 823, the vertical rotating sleeve 2 rotates, causing the arc-shaped tube 3 to rotate as well. One end of the arc-shaped tube 3 impacts the connected ion exchange resin. The ion exchange resin is transported upwards along the arc-shaped tube 3 and impacts the heparin sodium pretreatment solution, thereby dispersing the aggregated ion exchange resin. Simultaneously, under the action of the peak-valley annular trajectory disc 824, the gantry frame 822 reciprocates up and down. At this time, the vertical movement of the hanging shaft 5 drives the filter screen plate 6 and the electromagnetic plate 7 to move up and down. The magnetic force generated by the electromagnetic plate 7 pushes the arc tube 3 to change its tilt angle, thereby making the accumulated ion exchange resin fully dispersed and in full contact with the heparin sodium pretreatment solution, greatly improving the efficiency of ion exchange. After the ion exchange is completed, the pretreatment solution in the preparation cylinder 1 is discharged through the discharge pipe at the bottom of the preparation cylinder 1. Then, the ion exchange resin is eluted. During elution, a certain pressure of eluent is injected into the elution tube 23. The eluent enters the arc tube 3 along the annular cavity 22, the support tube 21 and the positioning tube 31. The eluent with a certain pressure will be sprayed outward through both ends of the arc tube 3. This setting makes the eluent have a comprehensive impact on the ion exchange resin, greatly improving the intensity of the elution impact. After the eluted liquid is discharged through the discharge pipe, the elution process is completed.

[0021] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A salt-free extraction and preparation apparatus for heparin sodium, comprising a preparation cylinder (1), characterized in that, The preparation cylinder (1) is equipped with a vertical rotating sleeve (2). The outer peripheral wall of the vertical rotating sleeve (2) is rotatably connected to an arc-shaped tube (3) via a support (21). The outer wall of the arc-shaped tube (3) is equipped with a magnetic support (4) near one end of the bottom. A hanging shaft (5) is slidably installed inside the vertical rotating sleeve (2). A filter screen plate (6) is installed at the bottom of the hanging shaft (5). An annular electromagnetic plate (7) is fixedly connected to the outer periphery of the filter screen plate (6) and is slidably sealed to the inner wall of the preparation cylinder (1). The annular electromagnetic plate (7) is located below the magnetic support (4). The outer wall of the preparation cylinder (1) is fitted with a heat-insulating circulating power water tank (8). The outer peripheral wall of the heat-insulating circulating power water tank (8) is equipped with a flow pipe (81) that connects to the inner cavity. The heat-insulating circulating power water tank (8) is equipped with a device for driving the vertical rotating sleeve (2) to rotate and the hanging shaft (5) to move up and down. The sliding transmission mechanism (82) includes an annular transmission disc (821), a gantry frame (822), a connecting rod (823), and a peak-valley annular track disc (824). The annular transmission disc (821) is located on the top of the insulated circulating power water tank (8), and the peak-valley annular track disc (824) is located inside the insulated circulating power water tank (8). Two columns (8221) on the gantry frame (822) pass through the annular transmission disc (821) and their bottoms roll in cooperation with the peak-valley annular track disc (824). The top of the vertical rotating sleeve (2) passes through the preparation cylinder (1) and is fixedly connected to one end of the connecting rod (823). The other end of the connecting rod (823) is fixedly connected to a sliding sleeve (8231) sleeved on the column (8221). The top of the hanging shaft (5) is fixedly connected to the top of the gantry frame (822).

2. The heparin sodium salt-free extraction and preparation apparatus according to claim 1, characterized in that, The arc center of the arc tube (3) coincides with the axis of the vertical rotating sleeve (2). The inner arc wall of the arc tube (3) is fixedly connected to a positioning tube (31) that is rotatably connected to the support tube (21). The middle part of the filter plate (6) is fixedly connected to a positioning sleeve (61) that is rotatably connected to the bottom of the hanging shaft (5).

3. The heparin sodium salt-free extraction and preparation apparatus according to claim 2, characterized in that, The flow pipe (81) and the outer peripheral wall of the preparation cylinder (1) are tangentially connected, and the lower end face of the annular transmission disc (821) is fixedly connected to a blade (8211) that extends into the heat-insulating circulating power water tank (8).

4. The apparatus for the salt-free extraction and preparation of heparin sodium according to claim 3, characterized in that, The top of the insulated circulating power water tank (8) is provided with an annular connecting hole, and the annular transmission disc (821) is sleeved in the annular connecting hole and is rotatably connected.

5. The heparin sodium salt-free extraction and preparation apparatus according to claim 2, characterized in that, The vertical rotating sleeve (2) has an annular cavity (22) that communicates with the support tube (21). The arc-shaped tube (3) is connected to the support tube (21) through the positioning tube (31). The top of the vertical rotating sleeve (2) is fixedly connected to the elution tube (23).

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