A traditional Chinese medicine composition for treating calculus

Abstract

The present application relates to a kind of traditional Chinese medicine composition for treating calculus, raw material is: walnut kernel 25-35 parts, black fungus 10-20 parts, giant knotweed 15-25 parts, powder 25-35 parts of yam, sea gold sand 25-35 parts, 10-20 parts of yujin, 25-35 parts of huashi grass, 25-35 parts of shaddock, 10-20 parts of goose tube stone, 25-35 parts of yiwren, 10-20 parts of magnolia officinalis, 25-35 parts of xuanming powder, 10-20 parts of rhubarb, 10-20 parts of plantago, 10-20 parts of bupleurum, 10-20 parts of small chrysanthemum, 5-10 parts of cumin, 10-20 parts of Sichuan donkey's hide, 5-10 parts of raw licorice.The present application has the effect of clearing heat and promoting bile secretion, dissolving stone and stopping bleeding cooling blood, through the concept of dissolving stone and expelling stone, large stone is small, small stone is small, gallstones are discharged with bile into intestine, kidney stones, ureter and bladder stones are discharged with urine, adjust liver, gallbladder, kidney and other qi stagnation, and be supplemented with constitution conditioning syndrome differentiation treatment, it has good curative effect on various stones of liver, gallbladder, kidney and urinary tract, and it is both the treatment of principle and secondary, relieve the suffering of the majority of patients.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of traditional Chinese medicine composition for treating calculus, belong to traditional Chinese medicine technical field. BACKGROUND

[0002] Calculus is a common disease, and the incidence rate gradually increases with age. Common calculi include gallbladder calculus, bile duct calculus, liver bile duct calculus, kidney calculus, ureteral calculus, etc. The causes of calculus are complex, and are mainly due to liver stagnation, liver and gallbladder damp-heat, bile duct obstruction, poor excretion, kidney qi deficiency, qi stagnation, improper diet, long sitting and long lying, and calculus formation. At present, the methods for treating calculus include western medicine and traditional Chinese medicine. Western medicine mainly uses surgical resection and mechanical lithotripsy, which is often traumatic and expensive, and is not easily accepted by patients. Western medicine also uses anti-inflammatory, analgesic, cholagogue and diuretic drugs for conservative treatment, but these methods only treat the symptoms and cannot cure the disease. Traditional Chinese medicine mainly uses traditional Chinese medicine for treatment, which often aims to remove stones and dissolve stones, and adjusts liver, gallbladder and kidney qi stagnation, and is supplemented by physical conditioning and syndrome differentiation treatment. Traditional Chinese medicine has less side effects and is easily accepted by patients. However, due to the anatomical and physiological characteristics of gallbladder, bile duct, liver bile duct, kidney and ureter, most calculi are not easy to expel, and there is no specific drug to resolve them. Inflammation is often eliminated and pain is relieved in clinical practice, and the effect is temporary. Therefore, it is necessary to develop a calculus traditional Chinese medicine with better efficacy and applicability. SUMMARY

[0003] In view of the deficiencies of the prior art, the present application provides a traditional Chinese medicine composition with better treatment effect, which can quickly promote the dispersion, dissolution and removal of calculus, and is suitable for the treatment of various calculi.

[0004] To achieve the above-mentioned purpose, the technical solution adopted by the present application is as follows:

[0005] A traditional Chinese medicine composition for treating calculus, which is composed of the following raw medicinal materials by weight: walnut kernel 25-35 parts, black fungus 10-20 parts, giant knotweed 15-25 parts, yam 25-35 parts, sea gold sand 25-35 parts, curcuma 10-20 parts, fossil herb 25-35 parts, immature fruit of citrus aurantium 25-35 parts, goose tube stone 10-20 parts, coix seed 25-35 parts, lindera 10-20 parts, talcum powder 25-35 parts, rhubarb 10-20 parts, plantago seed 10-20 parts, bupleurum 10-20 parts, small chrysanthemum 10-20 parts, cumin 5-10 parts, szechuan rhizome 10-20 parts, and raw licorice 5-10 parts.

[0006] Preferably, the traditional Chinese medicine composition comprises 30 parts of walnut kernel, 15 parts of black fungus, 20 parts of giant knotweed, 30 parts of radix alismatis, 30 parts of sea gold sand, 15 parts of curcuma, 30 parts of stone-fruited orange, 30 parts of goose pipe stone, 30 parts of coix seed, 15 parts of lindera, 30 parts of gypsum, 15 parts of rhubarb, 15 parts of plantago seed, 15 parts of bupleurum, 15 parts of small chrysanthemum, 9 parts of cumin, 15 parts of szechwan rhizome, and 6 parts of raw licorice.

[0007] The preparation method of the traditional Chinese medicine composition for treating calculi comprises the following steps: weighing and mixing the components, adding them into a pot, frying them on a small fire until they turn yellow, grinding them into 80-100 mesh powder, and preparing a powder according to a conventional method.

[0008] The traditional Chinese medicine composition can be a powder, a decoction, a granule, a pill or a capsule.

[0009] The traditional Chinese medicine composition can be used for preparing a medicine for treating calculi.

[0010] The pharmacological effects of the raw materials of the traditional Chinese medicine composition are as follows:

[0011] Walnut kernel is sweet and warm, and is attributed to kidney, lung and large intestine channels. It can tonify kidney, warm lung and moisten large intestine. It is used for kidney yang deficiency, lumbago and soreness of waist and knees, impotence and spermatorrhea, cold and asthmatic cough, and dry constipation.

[0012] Black fungus is flat, sweet, and is attributed to lung, spleen, large intestine and liver channels. It can tonify qi and blood, moisten lung to stop cough, stop bleeding, lower blood pressure and resist cancer. It belongs to cooling blood and stopping bleeding.

[0013] Giant knotweed is slightly bitter and cold, and is attributed to liver, gallbladder and lung channels. It can remove dampness and jaundice, clear heat and detoxify, remove blood stasis and relieve pain, and stop cough and reduce phlegm. It is used for damp-heat jaundice, leucorrhea, leucorrhoea, rheumatism, carbuncle and sore, water and fire burn, amenorrhea, abdominal mass, injury and lung heat cough.

[0014] Radix alismatis is bitter and flat, and is attributed to kidney and stomach channels. It can remove dampness and turbidity, dispel wind and relieve arthralgia. It is used for oedema, leucorrhea, excessive leucorrhoea, rheumatism, arthralgia, lumbago and soreness of waist and knees, especially for people who sit, lie and move little.

[0015] Sea gold sand is sweet and salty, and is attributed to bladder and small intestine channels. It can clear damp-heat, remove stone and relieve pain. It is used for hot leucorrhea, stone leucorrhea, blood leucorrhea, oedema, and urethral pain.

[0016] Curcuma is cold, and is attributed to liver, heart and lung channels. It can activate blood and relieve pain, remove blood stasis, clear heart and relieve depression, and remove gallbladder and jaundice.

[0017] Stone-fruited orange is slightly cold and sweet and bitter, and can clear heat and remove dampness, eliminate inflammation and detoxify, and is used for various calculi, nephritis, hepatitis, cystitis, high blood pressure, and external use for treating swelling, sore and dermatitis.

[0018] Aurantii Immaturi Fructus, bitter, pungent, sour, slightly cold; meridian-associations: spleen and stomach; breaking qi and resolving accumulation, resolving phlegm and dissipating mass; for accumulation and stagnation, distention and pain, diarrhea, constipation, dysentery, phlegm and qi stagnation, chest obstruction, prolapse of viscera.

[0019] Goutalith, sweet, warm; meridian-associations: lung, kidney, liver; warming lung, strengthening yang, promoting lactation; combined with sodium bicarbonate, it can dissolve many kinds of stones.

[0020] Coix Seed (raw), sweet, bland, cool; meridian-associations: spleen, stomach, lung; promoting urination to remove dampness, strengthening spleen to stop diarrhea, removing obstruction, pus discharge, detoxification and resolving mass; for edema, beriberi, dysuria, spleen deficiency and diarrhea, etc.

[0021] Lindera, warm, pungent; meridian-associations: lung, spleen, kidney, urinary bladder; regulating qi, relieving depression, dispelling cold and relieving pain.

[0022] Mirabilite (sodium bicarbonate), salty, bitter, cold; meridian-associations: stomach and large intestine; for diarrhea, constipation, damp-heat, clearing heat and resolving mass; for constipation, abdominal distention and pain, combined with Goutalith, it can dissolve 72 kinds of stones.

[0023] Rhubarb, bitter, cold; meridian-associations: spleen, stomach, large intestine, liver, pericardium; purgation and attack accumulation, clearing heat and purging fire, cooling blood and detoxification, removing blood stasis and unblocking channels, removing dampness and resolving jaundice; for constipation due to accumulation and stagnation of heat, blood-heat with vomiting and bleeding, red eyes and swollen throat, carbuncle and sores, intestinal abscess and abdominal pain, etc.

[0024] Plantaginis Semen, sweet, cold; meridian-associations: liver, kidney, lung, small intestine; clearing heat and promoting urination to remove dampness, removing dampness to stop diarrhea, clearing eyesight, resolving phlegm; for heat and pain in stranguria, edema, damp-heat diarrhea, red eyes and pain, phlegm-heat cough.

[0025] Bupleurum, slightly cold, bitter and pungent; meridian-associations: liver, gallbladder, lung; resolving the exterior and interior, soothing the liver and raising yang; anti-inflammatory, antipyretic, sedative, analgesic, antitussive and anticonvulsant effects.

[0026] Herba Hedyssari, cool, sweet and bitter; meridian-associations: heart and liver; treating acute nephritis, urinary tract infection, dysuria and edema; cooling blood to stop bleeding, removing blood stasis and resolving mass.

[0027] Fennel, pungent, warm; meridian-associations: liver, kidney, spleen, stomach; dispelling cold and relieving pain, regulating qi and harmonizing stomach; invigorating stomach, reducing body pain, helping and relieving convulsions.

[0028] Radix Cyathulae, sweet and slightly bitter, neutral; meridian-associations: liver and kidney; removing blood stasis and unblocking channels, promoting joint movement, promoting urination and removing dampness; for irregular menstruation, retained placenta, injury from falling, wind-damp arthralgia, foot atrophy and muscle spasm, hematuria and stranguria.

[0029] Raw Licorice, sweet, neutral; meridian-associations: heart, lung, spleen, stomach; tonifying spleen and qi, clearing heat and detoxification, resolving phlegm and relieving cough, relieving pain and regulating various drugs.

[0030] Advantages of the present application:

[0031] 1. The present application adopts the ancestral secret recipe, and through the TCM practice and exploration of several generations, a good medicine for treating calculi is summarized. The present application is aimed at the current situation that most of the gallbladder duct, liver duct, kidney ureter calculi are not easy to be discharged, and there is no specific drug to resolve it at present. In the clinic, the condition of anti-inflammatory and analgesic is mainly used, and the treatment concept of treating calculi is not in the lithotripsy, but in the dissolution of stones is invented. Through the method of dissolving small and small (smaller) stone, the gallbladder duct calculi is discharged into the intestine with bile, and the kidney stones, ureter and bladder stones are discharged with urine, so as to achieve the effect of combination, and the qi stagnation of liver, gallbladder, kidney and the like is adjusted, and the treatment is assisted by constitution conditioning and syndrome differentiation.

[0032] 2. The present application has good curative effect on various calculi of liver, gallbladder, kidney and urinary tract through careful selection of materials and reasonable compatibility. The combination of various drugs has the effects of clearing heat, promoting bile secretion, dissolving stones and stopping bleeding.

[0033] 3. The present application takes walnut kernel, natural black fungus, giant knotweed, yam, sea golden sand and curcuma as the monarch drugs, which are respectively meridian of liver, spleen, lung, gallbladder, kidney and large intestine. Because liver governs tendon, spleen governs transportation and transformation, lung governs all vessels, gallbladder governs excretion, kidney governs essence storage, lung and large intestine are exterior-interiorly related, and each viscera promotes and restricts each other, the present application has the effects of clearing heat and dampness, promoting bile secretion, dissolving stones and stopping bleeding, and is also effective for patients with long sitting and long lying.

[0034] The present application takes stone grass, bitter orange fruit, goose tube stone and gypsum powder as the minister drugs, which respectively have the effects of dilating bile duct, ureter and diuresis, especially the goose tube stone and gypsum powder can dissolve various stones, and the combination with the monarch drugs has synergistic effect.

[0035] The present application takes raw licorice, lindera and rhubarb as the auxiliary drugs, which have the effects of regulating qi and relieving depression and analgesia, and can prevent constipation and bile duct and ureter ulceration in the process of dissolving and discharging stones. The present application takes fennel, Chinese knotweed root, plantain seed, bupleurum and small thistle as the minister drugs, which have the effects of dilating bile duct and ureter, preventing obstruction and stopping bleeding.

[0036] The present application has good effects of dissolving and discharging stones. On the one hand, the present application expels evil and supports the healthy, makes water and wood strong and not love evil, on the other hand, the present application clears and purges evil, and the inflammation and stone dissolution do not hurt the healthy, which are complementary to each other. The combination of various drugs has the effects of clearing heat, promoting bile secretion and dissolving stones, so the effect is remarkable. The present application can not only relieve pain, but also resist bacteria and inflammation, so that the patients with calculi can recover soon.

[0037] 4. The present application has wide raw material sources and low treatment cost, and overcomes the problems of incomplete treatment, easy recurrence and high cost of the prior art, and has no toxic and side effects.

[0038] 5. The present application has significant effect in treating various kinds of stones, no adverse reaction, convenient to take, no recurrence after cure, cure rate is more than 85%, and total effective rate is more than 97%. The present application has fast effect and good effect, and can relieve the pain of patients. It is necessary to protect and popularize the present application in order to serve the society and carry forward the present application. DETAILED DESCRIPTION

[0039] The specific embodiment of the present application is further described in detail in combination with examples.

[0040] Example 1: A kind of traditional Chinese medicine composition for treating stones, which is composed of the following raw medicinal materials:

[0041] Walnut kernel 30 parts, black fungus 15 grams, giant knotweed 20 grams, yam 30 grams, sea gold sand 30 grams, curcuma 15 grams, stonecrop 30 grams, immature orange fruit 30 grams, goose tube stone 15 grams, coix seed 30 grams, magnolia bark 15 grams, talcum powder 30 grams, rhubarb 15 grams, plantain seed 15 grams, bupleurum 15 grams, small chrysanthemum 15 grams, cumin 9 grams, szechuan cow's hoof 15 grams, raw licorice 6 grams.

[0042] Preparation method: the above ingredients are weighed and mixed, then added into a pot, fried with small fire until yellow, then crushed into 80-100 mesh powder, and made into powder according to conventional method.

[0043] Usage and dosage: once a day in the morning and evening, 5-10 grams each time, taken with warm water before meal.

[0044] Example 2: A kind of traditional Chinese medicine composition for treating stones, which is composed of the following raw medicinal materials:

[0045] Walnut kernel 25 grams, black fungus 10 grams, giant knotweed 15 grams, yam 25 grams, sea gold sand 25 grams, curcuma 10 grams, stonecrop 25 grams, immature orange fruit 25 grams, goose tube stone 10 grams, coix seed 25 grams, magnolia bark 10 grams, talcum powder 25 grams, rhubarb 10 grams, plantain seed 10 grams, bupleurum 10 grams, small chrysanthemum 10 grams, cumin 5 grams, szechuan cow's hoof 10 grams, raw licorice 5 grams.

[0046] The preparation method of the traditional Chinese medicine is the same as example 1.

[0047] Example 3: A kind of traditional Chinese medicine composition for treating stones, which is composed of the following raw medicinal materials:

[0048] Walnut kernel 35 grams, black fungus 20 grams, giant knotweed 20 grams, yam 35 grams, sea gold sand 25 grams, curcuma 10 grams, stonecrop 35 grams, immature orange fruit 28 grams, goose tube stone 20 grams, coix seed 25 grams, magnolia bark 10 grams, talcum powder 35 grams, rhubarb 20 grams, plantain seed 20 grams, bupleurum 10 grams, small chrysanthemum 10 grams, cumin 5 grams, szechuan cow's hoof 20 grams, raw licorice 10 grams.

[0049] The preparation method of the traditional Chinese medicine is the same as that in Example 1.

[0050] Example 4 Toxicity Experiment

[0051] (1) Acute toxicity experiment

[0052] Experimental animals: 10 ordinary NIH mice, body weight 20g±2g, half male and half female.

[0053] The powder of Example 1 of the application was used for the mice at a dose of 1g / kg / day. After administration, the behavior and food intake of the mice were normal, and the fur was bright without any abnormalities. Five of them were dissected, and no abnormalities were found in the heart, liver, lung, stomach, thymus and other organs, indicating that the traditional Chinese medicine had no acute toxicity.

[0054] (2) Long-term toxicity experiment

[0055] Experimental animals: 80 SD rats, body weight 200g±10g, half male and half female.

[0056] The mice were divided into four groups, high, medium, low dose groups and a control group, 20 rats in each group. The dose groups were prepared with 100, 50 and 10 times the clinical drug amount, respectively. The control group was not given any medicine and was fed normally.

[0057] The powder of Example 1 of the application was used for the mice in each group for 3 months. The measurement showed that the physiological indicators of the mice in the four groups were normal, and the pathological report showed that the heart, liver, spleen, lung, kidney, stomach and other organs were not changed, confirming that the traditional Chinese medicine had no toxic effect on animals.

[0058] The above animal experiments confirmed that the traditional Chinese medicine of the application was safe and non-toxic.

[0059] Example 5 Application Example

[0060] In order to verify the efficacy of the traditional Chinese medicine of the application, the following clinical research is described.

[0061] 1. Patient statistics:

[0062] The traditional Chinese medicine composition of the application has been used in clinical practice for many years. From February 2018 to December 2022, 292 patients were recorded, of which 133 were female and 159 were male, with the oldest patient being 78 years old and the youngest being 17 years old. Among them, 119 cases were gallstones, 95 cases were kidney stones, and the rest were bladder stones. The largest stone was 2.2*1.6cm, and the smallest was 0.3*0.2cm.

[0063] 2. Diagnostic criteria:

[0064] The efficacy evaluation was based on the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines" (published by China Medical Science and Technology Press in 2002).

[0065] (1) Cure: All stones are discharged, clinical symptoms and signs disappear, B-ultrasound or X-ray examination is normal, review of stone discharge, no recurrence within 1 year;

[0066] (2) Marked effect: clinical symptoms and signs disappear, B-ultrasound or X-ray examination shows stone shrinkage or reduction;

[0067] (3) Ineffective: no obvious change in clinical symptoms, no obvious change or aggravation of stones in B-ultrasound or X-ray examination. Total effective rate = cure rate + effective rate.

[0068] 3. Treatment results:

[0069] According to the statistics of the treatment of the above-mentioned 292 patients, 251 cases were cured, 34 cases were effective, the cure rate was 85.9%, and the total effective rate was 97.6%.

[0070] 4. Typical cases

[0071] Case 1: Li, female, 39 years old, diagnosed in March 2007, the patient has multiple gallbladder stones, the largest 1.3x0.8cm, each recurrence unbearable pain, pain to shoulder and back, ready for surgical treatment. After being cured of gallstone patients introduced, the treatment of stone effect is better, to the inventor for treatment, according to the dosage and dosage of example 1, take the powder, the pain stops on the same day, the symptoms are relieved after three days, take medicine for more than thirty days, color Doppler ultrasound shows that the stones disappear, finally do abdominal CT, the stones are cured, and follow-up for more than ten years without recurrence.

[0072] Case 2: Wei, male, 64 years old, patient with bile duct stones for 5 years, the largest 1.4x0.7cm, often right costal pain, sometimes nausea and yellowish urine, during which different western medicine and traditional Chinese medicine treatment, but the effect is not good. Recently because of several nights, because of the introduction of 2009 August to find the inventor for treatment, observation of yellowish complexion, identify the use of previous drugs, change to take the invention example 1 of traditional Chinese medicine powder, each time 5-10g, morning and evening, before meal with warm water. Three days after taking the medicine, the right costal pain is relieved, continue to take medicine for 21 days, color Doppler ultrasound shows no gallbladder stones, right costal pain disappears, urine color is normal. Six months later, color Doppler ultrasound shows that the stones disappear, the stones are cured, and follow-up for 3 years without recurrence.

[0073] Case 3: Chang, male, 57 years old, the patient has difficulty urinating for half a year, color Doppler ultrasound shows multiple stones in the upper segment of both kidneys, the largest is 1.0*0.7 cm, waist pain, bladder distension, sometimes nausea after meals, cystitis, multiple lithotripsy failed, sometimes hematuria, later accompanied by hypertension, recently symptoms are serious. Listen to other patients, came to the inventor for treatment in March 2017, given the drug of Example 2, take five days to see effect, symptoms are reduced, continue to take for three weeks after recheck. The patient smiled and said, "I have been ill for many years, and I have been cured. I will continue to take medicine for a month. After color Doppler ultrasound examination, no stones were found, and the patient was cured. Later, follow-up for 2 years, no recurrence.

Claims

1. A traditional Chinese medicine composition for treating gallstones, characterized in that, It is made from the following raw materials in parts by weight: 25-35 parts walnut kernels, 10-20 parts black fungus, 15-25 parts Polygonum cuspidatum, 25-35 parts Dioscorea hypoglauca, 25-35 parts Lygodium japonicum, 10-20 parts Curcuma longa, 25-35 parts Fossilized grass, 25-35 parts Citrus aurantium, 10-20 parts Calcite, 25-35 parts Coix lacryma-jobi, 10-20 parts Lindera strychnifolia, 25-35 parts Glauber's salt, 10-20 parts Rheum palmatum, 10-20 parts Plantago asiatica, 10-20 parts Bupleurum chinense, 10-20 parts Cirsium japonicum, 5-10 parts Fennel, 10-20 parts Achyranthes bidentata, and 5-10 parts Glycyrrhiza uralensis.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It is made from the following raw materials in parts by weight: 30 parts walnut kernels, 15 parts black fungus, 20 parts Polygonum cuspidatum, 30 parts Dioscorea hypoglauca, 30 parts Lygodium japonicum, 15 parts Curcuma longa, 30 parts Fossilized grass, 30 parts Citrus aurantium, 15 parts Calcite, 30 parts Coix lacryma-jobi, 15 parts Lindera strychnifolia, 30 parts Glauber's salt, 15 parts Rheum palmatum, 15 parts Plantago asiatica, 15 parts Bupleurum chinense, 15 parts Cirsium japonicum, 9 parts Fennel, 15 parts Achyranthes bidentata, and 6 parts Glycyrrhiza uralensis.

3. A method for preparing a traditional Chinese medicine composition for treating gallstones according to claim 1 or 2, characterized in that: Mix the various components of the traditional Chinese medicine composition, add them to a pot, stir-fry over low heat until they turn yellow, then grind them into powder of 80-100 mesh, and prepare them into a powder according to conventional methods.

4. The use of the traditional Chinese medicine composition as described in claim 1 or 2 in the preparation of a medicament for treating gallstones.

5. A traditional Chinese medicine composition for treating gallstones according to claim 1 or 2, characterized in that, The traditional Chinese medicine composition is in the form of powder, decoction, granules, pills, or capsules.