Preparation method of freeze-dried medical dressing and freeze-dried medical dressing patch

Abstract

The present invention provides a preparation method of a freeze-dried medical dressing and a freeze-dried medical patch. The steps of the preparation method of the freeze-dried medical dressing are as follows: (1) Mix chitosan with deionized water and heat it to between 20 and 70 °C, stir well to completely dissolve it; (2) Slowly stir the solution obtained in step (1), and add methylcellulose and ceramide to the solution. After mixing evenly, cool it to between 10 and 20 °C, continue stirring, and add glycerol, triethanolamine, benzyl alcohol, fragrance, and disodium ethylenediaminetetraacetate to the resulting solution; (3) Put the raw materials stirred evenly in step (2) into a mold for freeze-drying to obtain the freeze-dried medical dressing. Adding ceramide and glycerol can increase the thickness of the epidermal stratum corneum, significantly enhance the adhesion between keratinocytes, improve the degree of skin dryness, reduce skin desquamation, and improve the water replenishment of skin cells. Moreover, chitosan has good antibacterial properties and can sterilize the skin surface.

Description

Technical Field

[0001] The present invention relates to the technical field of medical dressing production, and particularly relates to a preparation method of a freeze-dried medical dressing and a freeze-dried medical dressing. Background Art

[0002] Medical dressings are plasters improved based on traditional cold compress methods (such as cold water, ice water, alcohol, etc.). By vaporizing the water contained in the polymer gel and natural cooling components, heat can be taken away to achieve local cooling. The drug components are combined with the hydrogel, and through the hydration effect, the drug components can quickly penetrate the fat layer, penetrate into the subcutaneous tissue, reach the lesion site, act on the affected area, and achieve the effects of cold compress for relieving pain, transdermal absorption, and sustained-release drug delivery. Medical dressings can cause local capillary contraction, reduce local congestion, reduce the sensitivity of nerve endings to relieve pain, reduce fever by cooling, reduce local blood flow, and prevent the spread of inflammation and suppuration. They can conduct and dissipate the heat in the body, increase heat dissipation, and reduce body temperature. Cold compress is suitable for people who need cold compress, such as early local soft tissue injury, high fever patients, heatstroke patients, toothache, etc.

[0003] Existing medical dressings have poor water replenishing performance for the skin and the water replenishing effect is not good. Summary of the Invention

[0004] What the present invention aims to overcome is the problem that existing medical dressings have poor water replenishing performance for the skin and the water replenishing effect is not good. The purpose is to provide a preparation method of a freeze-dried medical dressing and a freeze-dried medical dressing.

[0005] The technical problems to be solved by the present invention are achieved by adopting the following technical solutions:

[0006] A preparation method of a freeze-dried medical dressing comprises the following steps:

[0007] Step (1): Mix chitosan with deionized water and heat it to 20 - 70 °C, stir well to completely dissolve it;

[0008] Step (2): Slowly stir the solution obtained in step (1), add methylcellulose and ceramide to the solution. After mixing evenly, cool it to 10 - 20 °C, continue stirring, and add glycerol, triethanolamine, benzyl alcohol, fragrance, and disodium ethylenediaminetetraacetate to the obtained solution;

[0009] Step (3): Put the raw materials stirred evenly in step (2) into a mold for freeze-drying to obtain a freeze-dried medical dressing.

[0010] Further, the weight parts of the freeze-dried medical dressing are composed of: 15-20 parts of chitosan, 5-7 parts of methylcellulose, 3-5 parts of ceramide, 5-10 parts of glycerol, 1-3 parts of triethanolamine, 0.05-0.2 parts of benzyl alcohol, 0.1-0.2 parts of fragrance, 0.5-1 part of disodium ethylenediaminetetraacetate, and 70-85 parts of deionized water.

[0011] Further, the conditions for freeze-drying treatment in step (3) are a temperature of -15 to -10 °C.

[0012] Further, the chitosan added in step (1) is 200-300 mesh micropowder particles.

[0013] A freeze-dried medical patch includes a freeze-dried medical dressing prepared by using the above-mentioned preparation method of the freeze-dried medical dressing. The medical patch further includes a first base film, a second base film, a release film, and a gauze layer;

[0014] The freeze-dried medical dressing is coated on the gauze layer by using an automatic coater. A diversion tube is fixedly installed on the first base film. The diversion tube forms a closed annular structure. The first base film and the second base film are thermally pressed and compounded. The gauze layer is arranged between the first base film and the second base film. The outer edge of the gauze layer extends into the interior of the diversion tube. A blank frame is provided in the middle of the second base film. The part of the gauze layer coated with the freeze-dried medical dressing is located within the blank frame. The release film is pasted on the freeze-dried medical dressing;

[0015] Liquid storage cylinders are equidistantly arranged on the diversion tube. The diversion tube is communicated with the liquid storage cylinders. The liquid storage cylinders are fixed on the first base film. A cover is provided at one end of the liquid storage cylinder far from the first base film. A piston is installed inside the liquid storage cylinder. A top pressure screw rod is rotatably connected to the piston. The top pressure screw rod passes through the cover through threaded connection. A turning handle is fixed at one end of the top pressure screw rod located outside the cover. The interior of the liquid storage cylinder is filled with a replenishing liquid.

[0016] The beneficial effects of the present invention are:

[0017] The structure of the present invention is simple. Adding ceramide and glycerol can increase the thickness of the epidermal stratum corneum, significantly enhance the adhesion between keratinocytes, improve the dryness of the skin, reduce skin desquamation, and improve the water replenishment of skin cells. Moreover, chitosan has good antibacterial properties and can sterilize the skin surface. Description of the Drawings

[0018] Figure 1 It is a cross-sectional view of the medical patch of the present invention;

[0019] Figure 2 It is a structural diagram of the automatic coater of the present invention;

[0020] Figure 3 It is a structural diagram of the cloth plate setting of the present invention;

[0021] Figure 4 The structural diagram of the adjustment ring of the present invention is provided;

[0022] Figure 5 It is a structural diagram of the drying mechanism of the present invention;

[0023] In the figure: 101, first base film; 102, second base film; 103, anti-adhesive film; 104, gauze layer; 105, guide tube; 106, blank frame; 107, liquid storage cylinder; 108, cover; 109, piston; 110, top pressure screw; 111, handle; 1, device base; 2, coating mechanism; 3, drying mechanism; 4, feeding conveyor belt; 5, table; 6, unwinding rack; 7, winding rack; 12, coating rack; 13, spiral feeding barrel; 14, coating head; 21, guide groove; 22, cloth plate; 23, material leveling rod; 24, support column; 25, top pressure sleeve; 26, limit groove; 27, guide convex strip; 28, adjusting screw; 29, limit Position plate; 30, toggle slot; 31, knob; 32, middle rod; 33, adjustment ring; 34, connecting rod; 35, limit ring groove; 36, sliding column; 37, buffer wheel; 51, support plate; 52, side plate; 53, lifting cylinder; 54, limit convex strip; 55, lifting column; 56, scraper; 57, connecting groove; 58, side support block; 59, crossbeam; 60, lifting screw; 61, driving gear; 62, transmission rod; 63, hand wheel; 71, oven; 72, upper drying rack; 73, lower drying rack; 74, heating tube; 75, first lifting rod; 76, slide seat; 77, second lifting rod; 78, vertical guide groove; 79, mounting seat; 80, horizontal axis. DETAILED DESCRIPTION

[0024] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below with reference to specific diagrams.

[0025] Example 1

[0026] A method for preparing a freeze-dried medical dressing, comprising the following steps:

[0027] (1) Mix chitosan and deionized water, heat to 20-70°C, and stir thoroughly to completely dissolve them;

[0028] (2) slowly stirring the solution obtained in step (1), and adding methylcellulose and ceramide to the solution. After the mixture is evenly mixed, the mixture is cooled to between 10° C. and 20° C., and the mixture is continuously stirred. Glycerin, triethanolamine, benzyl alcohol, fragrance, and disodium ethylenediaminetetraacetate are added to the obtained solution.

[0029] (3) The raw material after being evenly stirred in step (2) is put into a mold for freeze-drying to obtain a freeze-dried medical dressing.

[0030] The weight parts composition of the freeze-dried medical dressing is as follows: 15-20 parts of chitosan, 5-7 parts of methylcellulose, 3-5 parts of ceramide, 5-10 parts of glycerol, 1-3 parts of triethanolamine, 0.05-0.2 parts of benzyl alcohol, 0.1-0.2 parts of fragrance, 0.5-1 part of disodium ethylenediaminetetraacetate, and 70-85 parts of deionized water.

[0031] In step (3), the conditions for freeze-drying treatment are a temperature of -15 to -10 °C

[0032] The chitosan added in step (1) is a micropowder particle with a mesh size of 200-300.

[0033] Adding ceramide can increase the thickness of the epidermal stratum corneum, significantly enhance the adhesion between keratinocytes, improve skin dryness, reduce skin desquamation, and improve the water replenishment of skin cells. Moreover, chitosan has good antibacterial properties and can sterilize the skin surface.

[0034] Preparation of chitosan micropowder:

[0035] (1) Low-temperature plasma treatment: Put chitosan into the vacuum chamber of the plasma reactor, evacuate to 1 Pa, then introduce nitrogen until the vacuum chamber pressure reaches 10 Pa, control the temperature at 55-60 °C, the discharge power at 300-450 W, and the continuous discharge time at 5-10 min, and then stop discharging;

[0036] (2) Microwave treatment: Add water to the chitosan treated by low-temperature plasma and stir to make the water content reach 50-55 wt%, add a silane coupling agent, stir evenly, and then perform microwave treatment at a microwave frequency of 2450 MHz and an output power of 700 W for 3-5 min. After the microwave treatment, naturally cool to room temperature;

[0037] (3) Micronization: Send the chitosan treated by microwave into a freeze dryer, and the dried solid is made into micropowder by an ultrafine pulverizer to obtain chitosan micropowder.

[0038] Using the low-temperature plasma method, chitosan forms a three-dimensional network structure under the condition of no molecular chain breakage to improve the water absorption performance of the dressing.

[0039] Example 2

[0040] On the basis of Example 1, as Figure 1 shown; a freeze-dried medical dressing is prepared by the preparation method of the freeze-dried medical dressing to prepare a freeze-dried medical patch. The medical patch includes a first base film 101, a second base film 102, a release film 103, and a gauze layer 104;

[0041] The freeze-dried medical dressing is coated onto the gauze layer 104 using an automatic coater. A diversion tube 105 is fixedly installed on the first base film 101. The diversion tube 105 forms a closed annular structure. The first base film 101 and the second base film 102 are thermally pressed and compounded. The gauze layer 104 is arranged between the first base film 101 and the second base film 102. The outer edge of the gauze layer 104 extends into the interior of the diversion tube 105. A blank frame 106 is provided in the middle of the second base film 102. The part of the gauze layer 104 coated with the freeze-dried medical dressing is located within the blank frame 106. The anti-adhesive film 103 is pasted on the freeze-dried medical dressing;

[0042] There are liquid storage cylinders 107 at equal intervals on the diversion tube 105. The diversion tube 105 is communicated with the liquid storage cylinders 107. The liquid storage cylinders 107 are fixed on the first base film 101. A cover 108 is provided at one end of the liquid storage cylinder 107 away from the first base film 101. A piston 109 is installed inside the liquid storage cylinder 107. A top pressure screw 110 is rotatably connected to the piston 109. The top pressure screw 110 passes through the cover 108 by threaded connection. A turning handle 111 is fixed at one end of the top pressure screw 110 located outside the cover 108. The interior of the liquid storage cylinder 107 is filled with a replenishing liquid.

[0043] The replenishing liquid is deionized water.

[0044] As the moisture in the dressing vaporizes, the moisture in the dressing will slowly decrease, which will in turn reduce the service life of the dressing. By providing the liquid storage cylinder 107 and using the liquid storage cylinder 107 to store the replenishing liquid, when the moisture in the dressing decreases, by rotating the top pressure screw 110, the piston 109 in the liquid storage cylinder 107 is pushed to move, and the replenishing liquid in the liquid storage cylinder 107 is pushed out. The replenishing liquid penetrates through the gauze layer and enters the dressing to replenish water for the dressing, so as to increase the service life of the dressing.

[0045] Example 3

[0046] On the basis of Example 2, as Figures 2 - 4 shown; The automatic coater includes a device base 1, a coating mechanism 2, and a drying mechanism 3;

[0047] A feeding conveyor belt 4 is provided on the upper part of the device base 1. A platen 5 is provided below the belt surface of the feeding conveyor belt 4. The coating mechanism 2 is located above the feeding conveyor belt 4. A unwind rack 6 and a rewind rack 7 are respectively provided at both ends of the device base 1;

[0048] The coating mechanism 2 includes a coating rack 12, a spiral feeding cylinder 13, and a coating head 14; A coating rack 12 is provided on the device base 1. A spiral feeding cylinder 13 is installed on the coating rack 12. A coating head 14 is installed at the lower end of the spiral feeding cylinder 13;

[0049] A guide groove 21 is provided on one side of the lower port of the coating head 14, a material distribution plate 22 is slidably installed in the guide groove 21, a material leveling rod 23 is provided on the side of the material distribution plate 22, a support column 24 is provided on the coating frame 12, one end of the support column 24 is connected to the output end of the driving motor, a top pressure sleeve 25 is slidably installed on the support column 24, a limiting groove 26 is provided on the inner ring side of the top pressure sleeve 25, a guide convex strip 27 is provided on the outer side of the support column 24 along the axial direction, and the guide convex strip 27 is located inside the limiting groove 26, an adjusting screw 28 is installed on the coating frame 12 through a threaded connection, a limiting disk 29 is fixed at one end of the adjusting screw 28, a toggle groove 30 is provided on the outer ring of the top pressure sleeve 25, and a limiting groove 26 is provided on the inner ring side of the top pressure sleeve 25. The disk 29 slides in the toggle groove 30, and a knob 31 is fixedly installed at the other end of the adjusting screw 28. An intermediate rod 32 is rotated and passed through the support column 24, and the intermediate rod 32 is perpendicular to the axis of the support column 24. An adjusting ring 33 is installed on the support column 24, and the adjusting ring 33 is fixed on the intermediate rod 32. A connecting rod 34 is hinged on the top pressure sleeve 25, and the other end of the connecting rod 34 is hinged on the adjusting ring 33. The connecting rod 34 and the intermediate rod 32 are not on the same plane. A limiting ring groove 35 is provided on the outer ring of the adjusting ring 33, and a sliding column 36 is provided on the side of the cloth plate 22. A buffer wheel 37 is installed on the end of the sliding column 36, and the buffer wheel 37 is located inside the limiting ring groove 35.

[0050] By adjusting the adjustment screw 28 to rotate, the limit plate 29 is pushed to move, and the limit plate 29 drives the top pressure sleeve 25 to move along the axis direction of the support column 24. When the top pressure sleeve 25 moves, the connecting rod 34 connected thereto pushes the adjustment ring intermediate rod 32 to deflect, and at the same time, the driving motor drives the support column 24 to rotate, and the support column 24 drives the deflected adjustment ring 33 to rotate. During the rotation process, the limit ring groove 35 of its outer ring pushes the sliding column 36 to reciprocate along the axis direction of the support column 24, thereby driving the cloth plate 22 to reciprocate. When the rubber material output by the spiral feeding cylinder 13 passes through the cloth plate 22, the material leveling rod 23 on the cloth plate 22 can disperse the concentrated rubber material to prevent the rubber material from falling, so that the rubber material can be evenly distributed, and the uniformity of the coating of the rubber material is improved. The reciprocating amplitude of the cloth plate 22 can be adjusted according to the deflection amplitude of the adjustment ring 33. During the adjustment process, it is not necessary to turn off the driving motor, so as to realize the dynamic adjustment of the reciprocating amplitude of the cloth plate 22.

[0051] Example 4

[0052] On the basis of Example 3, Figures 2 - 4As shown in the figure; a support plate 51 is provided at the lower end of the coating head 14. Side plates 52 are respectively fixed on both sides of the support plate 51. The side plates 52 are arranged closely against the fabric plate 22. The side plates 52, the support plate 51, and the fabric plate 22 form a cylindrical structure. A lifting cylinder 53 is provided at the lower end of the coating head 14. The upper end of the lifting cylinder 53 is slidably inserted into the cylindrical structure formed by the side plates 52, the support plate 51, and the fabric plate 22. A limiting rib 54 is provided on one side of the lifting cylinder 53. A lifting column 55 is slidably inserted into the lower end of the fabric plate 22. A scraper 56 is fixed at the lower end of the lifting column 55. A connecting groove 57 is provided on the scraper 56. The limiting rib 54 is slidably located inside the connecting groove 57. A side support block 58 is provided on the side of the lifting cylinder 53. The scraper 56 is arranged closely against the outer side wall of the lifting cylinder 53. A cross beam 59 is provided on the coating rack 12. A lifting screw 60 is rotatably installed on the cross beam 59. The lower end of the lifting screw 60 is threadedly connected and passes through the side support block 58. A driving gear 61 is installed at the upper end of the lifting screw 60. A transmission rod 62 is rotatably installed on the upper part of the cross beam 59. The transmission rod 62 and the driving gear 61 form a worm and worm gear mechanism. A hand wheel 63 is installed at one end of the transmission rod 62.

[0053] The lifting column 55 is perpendicular to the support column 24.

[0054] The lifting screw 60 is parallel to the scraper 56, and the lifting screw 60 is perpendicular to the support column 24.

[0055] During the coating process, it is necessary to adjust the coating thickness of the sizing material. By rotating the hand wheel 63, the transmission rod 62 is driven to rotate. The transmission rod 62 drives the driving gear 61 to rotate. The driving gear 61 pushes the side support block 58 to lift along the axis direction of the lifting screw 60, thereby driving the lifting cylinder 53 to move up and down. When the lifting cylinder 53 moves, the scraper 56 is driven to move, so as to adjust the distance between the scraper 56 and the backing layer, and further adjust the coating thickness of the sizing material. The scraper 56 is connected to the fabric plate 22 through the lifting column 55, and thus the scraper 56 can be driven to reciprocate for coating, improving the uniformity of the coating.

[0056] Embodiment 5

[0057] On the basis of Embodiment 3, as Figures 2 - 5 shown in the figure; the drying mechanism 3 includes an oven 71. The oven 71 is installed on the device base 1. An upper drying rack 72 and a lower drying rack 73 are provided inside the oven 71. Heating tubes 74 are installed on both the upper drying rack 72 and the lower drying rack 73. Two first lifting rods 75 are hinged on the upper part of the upper drying rack 72. The upper end of each first lifting rod 75 is hinged to a slide seat 76 one by one. A second lifting rod 77 is hinged on the upper end face of the oven 71. The lower end of the second lifting rod 77 is hinged to the slide seat 76 one by one. A vertical guide groove 78 is provided on the side of the oven 71. A mounting seat 79 slides in the vertical guide groove 78. A horizontal shaft 80 is rotatably installed on the mounting seat 79. The horizontal shaft 80 is threadedly connected and passes through the slide seat 76. The thread directions of the two slide seats 76 connected to the horizontal shaft 80 are opposite.

[0058] By rotating the horizontal shaft 80, the two sliding seats 76 on the horizontal shaft 80 are driven to move. When the moving distances of the two sliding seats 76 are close to each other, the first lifting rod 75 and the second lifting rod 77 are opened, and then the upper drying rack 72 descends. Conversely, the upper drying rack 72 is adjusted to rise, so as to adjust the distance between the heating tube 74 on the upper drying rack 72 and the coating material.

[0059] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A preparation method of a freeze-dried medical dressing, characterized in that, The steps are as follows: Step (1): Mix chitosan with deionized water and heat it to a temperature between 20 and 70 °C, and stir well to completely dissolve it; Step (2): Slowly stir the solution obtained in step (1), and add methylcellulose and ceramide to the solution. After mixing evenly, cool it to a temperature between 10 and 20 °C, continue stirring, and add glycerol, triethanolamine, benzyl alcohol, fragrance, and disodium ethylenediaminetetraacetate to the resulting solution; Step (3): Put the raw materials stirred evenly in step (2) into a mold for freeze-drying to obtain a freeze-dried medical dressing; The freeze-dried medical dressing prepared by the above-mentioned preparation method of the freeze-dried medical dressing, the medical dressing also includes a first base film, a second base film, a release film, and a gauze layer; Coat the freeze-dried medical dressing onto the gauze layer using an automatic coater. A flow guide tube is fixedly installed on the first base film. The flow guide tube forms a closed annular structure. The first base film and the second base film are thermally pressed and compounded. The gauze layer is arranged between the first base film and the second base film. The outer edge of the gauze layer extends into the interior of the flow guide tube. A blank frame is provided in the middle of the second base film. The part of the gauze layer coated with the freeze-dried medical dressing is located within the blank frame. The release film is pasted on the freeze-dried medical dressing; Liquid storage cylinders are equidistantly arranged on the flow guide tube. The flow guide tube is communicated with the liquid storage cylinders. The liquid storage cylinders are fixed on the first base film. A seal cover is provided at one end of the liquid storage cylinder away from the first base film. A piston is installed inside the liquid storage cylinder. A top pressure screw rod is rotatably connected to the piston. The top pressure screw rod passes through the seal cover by threaded connection. A turning handle is fixed at one end of the top pressure screw rod outside the seal cover. A replenishing liquid is filled inside the liquid storage cylinder; The replenishing liquid is deionized water.

2. The preparation method of a freeze-dried medical dressing according to claim 1, characterized in that, The weight parts composition of the freeze-dried medical dressing is: 15 - 20 parts of chitosan, 5 - 7 parts of methylcellulose, 3 - 5 parts of ceramide, 5 - 10 parts of glycerol, 1 - 3 parts of triethanolamine, 0.05 - 0.2 parts of benzyl alcohol, 0.1 - 0.2 parts of fragrance, 0.5 - 1 part of disodium ethylenediaminetetraacetate, and 70 - 85 parts of deionized water.

3. The preparation method of a freeze-dried medical dressing according to claim 1, characterized in that, The conditions for the freeze-drying treatment in step (3) are a temperature of -15 to -10 °C.

4. The preparation method of a freeze-dried medical dressing according to claim 1, characterized in that, The chitosan added in step (1) is fine powder particles with a mesh size of 200 - 300.

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