Traditional Chinese medicine pill forming process and equipment

Abstract

The application discloses a traditional Chinese medicine pill forming process and equipment, and relates to the technical field of traditional Chinese medicine pills. The process first prepares raw materials into medicine blanks with a thickness of 1-4 mm; then the medicine blanks are vacuum dried at 4-30 DEG C, and then crushed into fine powder to obtain standby medicine powder; then starch, hydroxypropyl cellulose and the standby medicine powder are mixed according to a weight ratio of 1:(0.8-1.2):(190-210), and then pressed into pills to obtain original medicine pills; then polyvinyl alcohol, cross-linked povidone, a lubricant, a colorant and a flavoring agent are uniformly mixed and coated on the surface of the original medicine pills, and after coating, the traditional Chinese medicine pills are obtained; the equipment of the application is used to implement the above process. The process of the application improves the storage effect of the traditional Chinese medicine pills, reduces the loss of the medicinal effect of the traditional Chinese medicine pills caused by storage, and the equipment of the application helps to improve the efficiency.

Description

Technical Field

[0001] This invention relates to the technical field of traditional Chinese medicine pills, and in particular to a process and equipment for forming traditional Chinese medicine pills. Background Technology

[0002] Traditional Chinese medicine (TCM) and its herbal remedies are treasures of my country's traditional culture. Inheriting and developing TCM and its herbal remedies is of great significance to national health and the national economy. Modernizing TCM production technology is crucial for its development, as it can not only increase yield but also enhance efficacy. TCM is available in various dosage forms, including decoctions, tablets, and pills. Among these, pills are spherical or near-spherical preparations made from finely powdered or extracted medicinal herbs with suitable excipients, making them convenient for patients to take.

[0003] Among related technologies, a styrax pill is disclosed, comprising the following components: 50g styrax, 100g benzoin, 50g borneol, 200g concentrated buffalo horn powder, 75g artificial musk, 100g sandalwood, 100g agarwood, 100g cloves, 100g cyperus rotundus, 100g costus root, 100g prepared frankincense, 100g long pepper, 100g atractylodes macrocephala, 100g chebula pulp, and 100g cinnabar. The preparation method involves pulverizing the medicinal herbs in the traditional Chinese medicine prescription into a fine powder, using water as a binder, and forming the pills by hand. The pills are then dried in a traditional drying room to obtain the traditional Chinese medicine pills. They are used for phlegm-induced syncope and coma, stroke-induced hemiplegia, limb weakness, as well as heatstroke and stomach pain.

[0004] However, the styrax pills produced by the above manufacturing method are large, reddish-brown honey pills that need to be sealed and stored to prevent moisture, mold, and insects. Moreover, some of the medicinal ingredients, such as borneol, are volatile and not easy to store for a long time. Therefore, the above-mentioned styrax pills are prone to loss of efficacy during storage, making them difficult to preserve. Summary of the Invention

[0005] In order to improve the preservation effect of traditional Chinese medicine pills and reduce the loss of efficacy caused by preservation, this application provides a traditional Chinese medicine pill forming process and equipment.

[0006] In the first aspect, this application provides a process for forming traditional Chinese medicine pills, which adopts the following technical solution:

[0007] A process for forming traditional Chinese medicine pills includes the following steps:

[0008] Preparation: Weigh out styrax, benzoin, borneol, concentrated buffalo horn powder, artificial musk, sandalwood, agarwood, cloves, cyperus, costus root, frankincense (processed), long pepper, atractylodes, chebula, and cinnabar; grind the cinnabar into a fine powder; grind benzoin, sandalwood, agarwood, cloves, cyperus, costus root, frankincense (processed), long pepper, atractylodes, chebula, borneol, concentrated buffalo horn powder, and artificial musk into fine powders respectively; mix all the above fine powders to obtain a mixed medicinal powder; stew styrax until dissolved and add it to the mixed medicinal powder, mix evenly, and roll into sheets to obtain a medicinal blank with a thickness of 1-4 mm;

[0009] Powdering: The raw medicinal material is vacuum dried at 4-30℃, and then pulverized into fine powder to obtain the powder for later use;

[0010] Dry pill making: Weigh starch and hydroxypropyl cellulose, mix starch, hydroxypropyl cellulose and prepared medicine powder in a weight ratio of 1:(0.8-1.2):(190-210), and then compress into pills to obtain the original medicine pills;

[0011] Coating: Weigh out polyvinyl alcohol, crospovidone, lubricant, colorant and flavoring agent, mix them evenly, and coat them on the surface of the original pill to form a coating, thus obtaining the traditional Chinese medicine pill.

[0012] By adopting the above technical solution, the process of this application first prepares a sheet-like medicinal preform with a large surface area and thin thickness, which helps to reduce drying time and allows the preform to dry quickly. Furthermore, drying at the specified temperature helps to reduce the volatilization of drug components such as borneol. After drying, the preform is pulverized into powder and mixed with starch and hydroxypropyl cellulose. This powder is then pressed into pills without adding liquid, thus reducing the moisture content of the original pills. Coating the surface of the original pills isolates them from the external environment, creating an environment unsuitable for microbial growth inside the coating, inhibiting microbial reproduction within the coating, and reducing the loss of effective drug components. Since the coating uses crospovidone and the original pills use hydroxypropyl cellulose, both excellent disintegrants, the coating and the original pills can disintegrate rapidly after being swallowed by the patient, facilitating rapid efficacy. In summary, the process of this application improves the preservation effect of traditional Chinese medicine pills and reduces the loss of efficacy due to storage.

[0013] Secondly, this application provides an apparatus for implementing the above-mentioned traditional Chinese medicine pill forming process, which adopts the following technical solution:

[0014] An apparatus for implementing the above-mentioned traditional Chinese medicine pill forming process includes a blank-making mechanism, a powder-making mechanism, a dry pelletizing mechanism, and a coating mechanism. The blank-making mechanism includes a raw material pulverizer, a dry material mixer, a reaction vessel, and a twin-roll calender arranged in sequence. The reaction vessel is equipped with a mixing agitator, and the twin-roll calender is equipped with a shearing component. The powder-making mechanism includes an automatic material transfer rack, a vacuum drying chamber, and a medicinal blank pulverizer arranged in sequence. The automatic material transfer rack is used to transfer the medicinal blanks output from the twin-roll calender to the vacuum drying chamber. The dry pelletizing mechanism is used to press the spare medicinal powder output from the medicinal blank pulverizer into raw medicinal pills. The coating mechanism is used to coat the raw medicinal pills.

[0015] By adopting the above technical solution, the raw material pulverizer pulverizes the raw materials and then feeds them into a dry material mixer for uniform mixing to obtain a mixed medicinal powder. A reaction vessel is used to stew styrax. After the mixed medicinal powder is fed into the reaction vessel, a mixing agitator can evenly mix the mixed medicinal powder with the stewed styrax. A double-roll calender can calender the mixed material into sheets, facilitating the preparation of medicinal blanks. A shearing device is used to cut the medicinal blanks. An automatic transfer rack automatically moves the medicinal blanks to a vacuum drying oven. After drying, the automatic transfer rack then conveys the medicinal blanks to a medicinal blank pulverizer for further pulverization. Then, a dry pelletizing mechanism presses the powder into pellets, and a coating mechanism coats the pellets to obtain traditional Chinese medicine pills, thus improving efficiency.

[0016] In one specific implementation, the shearing component includes a shearing frame, a blade, a base plate, and a power cylinder. The shearing frame is mounted on a twin-roll calender. The power cylinder and the base plate are both fixedly connected to the shearing frame. The power cylinder is opposite to the base plate. The blade is slidably connected to the shearing frame and is located between the power cylinder and the base plate. The power cylinder is fixedly connected to the blade.

[0017] By adopting the above technical solution, when the drug blank is inserted between the blade and the base plate, the operating power cylinder pushes the blade to move, and the blade can cut the drug blank.

[0018] In one specific implementation scheme, the automatic transfer rack includes a ring track, a moving trolley, a drying rack, a lifting cylinder for driving the drying rack to rise and fall, and a push-pull component for pushing and pulling the drying rack. Several moving trolleys are slidably connected to the ring track. The lifting cylinder is located on the moving trolley, and the push-pull component is located on the drying rack. Both the lifting cylinder and the push-pull component are connected to the drying rack. The double-roll calender, vacuum drying oven, and pharmaceutical blank pulverizer are all located around the ring track.

[0019] By adopting the above technical solution, the drying rack moves synchronously along the circular track using a mobile trolley. When a drying rack reaches the twin-roll calender, it can receive the pharmaceutical blanks output from the twin-roll calender. The shearing component cuts the pharmaceutical blanks into appropriate lengths. When the lifting cylinder pushes the drying rack upwards, a section of pharmaceutical blank can be placed at different heights on the drying rack, thus allowing multiple sections of pharmaceutical blanks to be dried simultaneously, further improving production efficiency. The push-pull component can push the drying rack into or pull it out of the vacuum drying chamber. While one mobile trolley transports dried pharmaceutical blanks, another mobile trolley can move an empty drying rack to the twin-roll calender, which is beneficial for continuously drying multiple batches of pharmaceutical blanks, resulting in higher efficiency.

[0020] In one specific implementation, the drying rack includes a base cylinder, a slide rod, a support plate, and a movable frame. The base cylinder is fixedly connected to a moving trolley, the slide rod is inserted into the base cylinder, the support plate is fixedly connected to the slide rod, the movable frame is mounted on the support plate, the lifting cylinder is located below the support plate and is fixedly connected to the support plate, the push-pull member is mounted on the support plate, and the push-pull member is detachably connected to the movable frame.

[0021] By adopting the above technical solution, when the lifting cylinder pushes the support plate up or down, the slide rod slides inside the base cylinder, which helps to reduce the swaying of the support plate during the lifting process. The push-pull component drives the moving frame to move on the surface of the support plate, thus transferring the moving frame into the vacuum drying oven.

[0022] In one specific implementation, the movable frame includes a vertical rod, a frame, support bars, ball bearings, a shaft, and wheels. Several frames are fixedly connected to the vertical rod in an upward direction. The vertical rod is fixedly connected to the shaft. The wheels are rotatably connected to the end of the shaft. Several support bars are rotatably connected to the frame, and several wheels are fixedly connected to the support bars.

[0023] By adopting the above technical solution, when the medicine blank is conveyed to the uppermost support bar, the support bar rotates under the friction of the medicine blank, which helps the medicine blank to unfold and be placed, and also helps the medicine blank to dry. The lifting cylinder pushes the support plate to rise, and the entire moving frame can be raised, so that the medicine blanks can be placed on the support bars at different heights.

[0024] In one specific implementation scheme, the mobile trolley includes a platform, wheels, a drive motor, a drive gear, and abutment wheels. The wheels, drive motor, and abutment wheels are all mounted on the platform. The drive gear is fixedly connected to the motor shaft of the drive motor. The ring track passes between the drive gear and the abutment wheels. The drive gear meshes with the outer peripheral wall of the ring track, and the abutment wheels abut against the inner peripheral wall of the ring track. The lifting cylinder and the drying rack are both located on the platform.

[0025] By adopting the above technical solution, the abutment wheel and the drive gear clamp the ring track, and the drive motor drives the drive gear to rotate, so that the entire moving trolley can move along the ring track, thereby moving the drying rack to different positions and achieving the effect of automatically transferring the medicine blank.

[0026] In one specific implementation scheme, the push-pull component includes a push-pull cylinder, a mounting block, a drive motor, a drive gear, a rotating rod, a gear ring, and a locking block. The push-pull cylinder is fixedly connected to the moving trolley, the mounting block is fixedly connected to the telescopic end of the push-pull cylinder, the drive motor is fixedly connected to the mounting block, the drive gear is fixedly connected to the motor shaft of the drive motor, one end of the rotating rod is rotatably connected to the mounting block, the other end of the rotating rod is fixedly connected to the locking block, the gear ring is sleeved on the rotating rod, the gear ring is fixedly connected to the rotating rod, the drive gear meshes with the gear ring, and the locking block is provided with a locking groove.

[0027] By adopting the above technical solution, the drive motor drives the rotating rod to rotate, the locking block can rotate, and the moving frame can be inserted into the groove and engaged with the locking block. At this time, the push-pull cylinder pushes or pulls the moving frame to move, so that the medicine blank can be sent into the vacuum drying oven or removed from the vacuum drying oven.

[0028] In summary, this application includes at least one of the following beneficial technical effects:

[0029] 1. The process described in this application improves the preservation effect of traditional Chinese medicine pills and reduces the loss of efficacy caused by preservation.

[0030] 2. The equipment described in this application can be used to implement the process described in this application, which helps to improve efficiency;

[0031] 3. The automatic transfer rack of this application can place the drug blank into a vacuum drying oven for drying. Attached Figure Description

[0032] Figure 1 This is a schematic diagram of the overall structure of the equipment used to prepare traditional Chinese medicine pills in Embodiment 1 of this application.

[0033] Figure 2 This is a schematic diagram of the raw material crusher, dry material mixer, and reaction vessel in Embodiment 1 of this application.

[0034] Figure 3 This is a schematic diagram of the shearing component and the powder-making mechanism in Embodiment 1 of this application.

[0035] Figure 4 yes Figure 3 Enlarged view of point A in the middle.

[0036] Figure 5 This is a schematic diagram of the structure of the mobile trolley and drying rack in Embodiment 1 of this application.

[0037] Figure 6 This is an exploded view of the drying rack in Embodiment 1 of this application.

[0038] Figure 7 This is a cross-sectional view of the push-pull component in Embodiment 1 of this application.

[0039] Explanation of reference numerals in the attached figures:

[0040] 1. Preform making mechanism; 11. Raw material crusher; 12. Dry material mixer; 13. Reactor; 14. Double roll calender; 15. Mixing agitator; 16. Shearing parts; 161. Shearing frame; 1611. Wheel groove; 162. Blade; 1621. Drag-reducing wheel; 163. Base plate; 164. Power cylinder; 2. Powder making mechanism; 21. Automatic material transfer frame; 22. Vacuum drying oven; 23. Preform crusher; 24. Circular track; 25. Moving trolley; 251. Car platform; 252. Wheel; 253. Drive motor; 254. Drive gear; 255. Abutment wheel; 26. Drying rack; 261. Base cylinder; 262. Slide rod; 2 63. Support plate; 264. Movable frame; 2641. Vertical rod; 2642. Frame; 2643. Support bar; 2644. Ball bearing; 2645. Shaft; 2646. Rotary wheel; 2647. Wheel hole; 2648. Ring groove; 2649. Through hole; 27. Lifting cylinder; 28. Push-pull component; 281. Push-pull cylinder; 282. Mounting block; 2821. Insertion hole; 2822. Rotating groove; 283. Drive motor; 284. Drive gear; 285. Rotating rod; 2851. Rod body; 2852. Rotating block; 286. Gear ring; 287. Locking block; 288. Locking groove; 3. Dry shot pressing mechanism; 4. Coating mechanism. Detailed Implementation

[0041] The following is in conjunction with the appendix Figure 1-7 The present application will be further described in detail with reference to the embodiments.

[0042] Example

[0043] Example 1

[0044] Reference Figure 1 This embodiment provides an apparatus for preparing traditional Chinese medicine pills, including a blank-forming mechanism 1, a powder-making mechanism 2, a dry-forming pill-pressing mechanism 3, and a coating mechanism 4 arranged in sequence.

[0045] The raw material is placed into the preforming mechanism 1, which forms a tablet-shaped preform. The preform is then conveyed to the powdering mechanism 2, which forms a powder. This powder is then conveyed to the dry pelleting mechanism 3, a standard dry granulation machine (such as the GZL-240 model), which compresses the powder into pills. Finally, the pills are conveyed to the coating mechanism 4, a standard fully automatic coating machine (such as the BG-100E model), which coats the pills, thus obtaining the traditional Chinese medicine pills.

[0046] Reference Figure 1 and Figure 2 The billet-making mechanism 1 includes, from top to bottom, a raw material crusher 11, a dry material mixer 12, and a reaction vessel 13, as well as a double-roll calender 14 located on one side of the reaction vessel 13. The raw material crusher 11 is a conventional crusher, the dry material mixer 12 is a conventional drum-type mixer, the reaction vessel 13 is a conventional jacketed kettle, a mixing agitator 15 is fixedly connected to the reaction vessel 13, the mixing agitator 15 is a conventional agitator, the mixing end of the mixing agitator 15 is inserted into the reaction vessel 13, and the double-roll calender 14 is a conventional double-roll calender 14, with a shearing piece 16 at the discharge end of the double-roll calender 14.

[0047] The raw materials are fed into the raw material pulverizer 11 for pulverization, and then the pulverized powder is conveyed to the dry material mixer 12, where it is mixed evenly to obtain a mixed powder. Simultaneously, the material inside the reaction vessel 13 is heated. Once the material in the vessel has melted, the mixed powder is added to the reaction vessel 13. The mixing agitator 15 continuously stirs the material in the reaction vessel 13 until it is evenly mixed. The material in the reaction vessel 13 is then removed and calendered into sheets using a double-roll calender 14 to obtain a drug blank. When the drug blank reaches a suitable length, the shearing device 16 cuts it. The thickness of the drug blank can be between 1-4 mm; in this embodiment, the drug blank thickness is 2 mm.

[0048] Reference Figure 3 and Figure 4The shearing component 16 includes a shearing frame 161, a blade 162, a base plate 163, and a power cylinder 164. The shearing frame 161 is riveted to the discharge end of the twin-roll calender 14. The blade 162, base plate 163, and power cylinder 164 are all located inside the shearing frame 161. The base plate 163 is welded to the inner wall of the shearing frame 161, and the power cylinder 164 is welded to the top of the shearing frame 161, with the telescopic end of the power cylinder 164 facing the base plate 163. The blade 162 is located between the power cylinder 164 and the base plate 163. A drag-reducing wheel 1621 is installed at both ends of the blade 162. A wheel groove 1611 is provided on the inner wall of the shearing frame 161. The drag-reducing wheel 1621 is inserted into the wheel groove 1611 and abuts against the groove wall. The length direction of the wheel groove 1611 is the same as the length direction of the power cylinder 164. The telescopic end of the power cylinder 164 is riveted to the blade 162.

[0049] The medicine blank is inserted between the blade 162 and the base plate 163. When the medicine blank is output to a suitable length, the power cylinder 164 is activated to extend. The power cylinder 164 drives the blade 162 to move. When the blade 162 comes into contact with the base plate 163, the medicine blank is cut off.

[0050] Reference Figure 3 and Figure 5 The powder making mechanism 2 includes an automatic transfer rack 21, a vacuum drying chamber 22, and a medicinal material pulverizer 23 arranged in sequence. The automatic transfer rack 21 is located at the discharge end of the double-roll calender 14. The vacuum drying chamber 22 and the medicinal material pulverizer 23 are both located next to the automatic transfer rack 21. The vacuum drying chamber 22 is a conventional vacuum drying chamber 22, and the medicinal material pulverizer 23 is a conventional pulverizer.

[0051] Reference Figure 5 and Figure 6 The automatic transfer rack 21 includes a ring track 24, a moving trolley 25, a drying rack 26, a lifting cylinder 27, and a push-pull component 28. The ring track 24 is located on the ground, and the moving trolleys 25 are located on the ring track 24. There can be two, three, four, or five moving trolleys 25, etc. In this embodiment, there are three moving trolleys 25. Each moving trolley 25 is equipped with a drying rack 26 and a lifting cylinder 27, and the push-pull component 28 is located on the drying rack 26.

[0052] The trolley 25 moves along the ring track 24, the lifting cylinder 27 pushes the drying rack 26 up or down, and the push-pull component 28 pushes the drying rack 26 to move.

[0053] The mobile trolley 25 includes a platform 251, wheels 252, a drive motor 253, a drive gear 254, and abutment wheels 255. There are four wheels 252, which are mounted at the four corners of the platform 251. The platform 251 is positioned above the ring track 24. The drive motor 253 is riveted to the platform 251. The drive gear 254 is integrally connected to the motor shaft of the drive motor 253 and is located below the platform 251. The abutment wheels 255 are mounted on the bottom wall of the platform 251. The ring track 24 passes between the drive gear 254 and the abutment wheels 255. The drive gear 254 meshes with the outer peripheral wall of the ring track 24, and the abutment wheels 255 abut against the inner peripheral wall of the ring track 24.

[0054] The drying rack 26 includes four base cylinders 261, sliding rods 262, support plates 263, and a movable frame 264. Each base cylinder 261 is riveted vertically to the upper surface of the vehicle platform 251. A sliding rod 262 is inserted into each base cylinder 261. The support plate 263 is located above the sliding rods 262, and the top of the sliding rods 262 is riveted to the support plate 263. The movable frame 264 is placed on the support plate 263.

[0055] The lifting cylinder 27 is riveted vertically to the upper surface of the vehicle plate 251. The lifting cylinder 27 is located below the support plate 263, and its top end is riveted to the support plate 263. The push-pull component 28 is mounted on the support plate 263 and is connected to the movable frame 264.

[0056] The movable frame 264 includes vertical rods 2641, a frame 2642, support bars 2643, ball bearings 2644, shafts 2645, and wheels 2646. There are two shafts 2645, both horizontally oriented. Each shaft 2645 has a wheel 2646 at both ends, with wheel holes 2647 on each wheel. Each shaft 2645 also has annular grooves 2648 at both ends. The shaft 2645 is inserted into the wheel holes 2647, and the wheel 2646 engages with the annular grooves 2648. The wheel 2646 abuts against the support plate 263. Two vertical rods 2641 are welded to each shaft 2645, both vertically oriented. There are four frames 2642, arranged sequentially from top to bottom. Each frame 2642 is located between two vertical rods 2641 on the same shaft 2645, and the frames 2642 are welded to the vertical rods 2641. Each frame 2642 contains several support bars 2643. Both sides of each frame 2642 have through holes 2649, and both ends of the support bars 2643 are inserted into the through holes 2649. Several ball bearings 2644 are welded onto each support bar 2643.

[0057] Reference Figure 6 and Figure 7The push-pull component 28 includes a push-pull cylinder 281, a mounting block 282, a drive motor 283, a drive gear 284, a rotating rod 285, a gear ring 286, and a locking block 287. The push-pull cylinder 281 is riveted horizontally to the upper surface of the support plate 263, with its telescopic end facing the shaft 2645. The mounting block 282 is riveted to the telescopic end of the push-pull cylinder 281. The drive motor 283 is riveted to the mounting block 282, and the drive gear 284 is coaxially connected to the motor shaft of the drive motor 283.

[0058] The mounting block 282 has an insertion hole 2821 on its side wall facing the shaft 2645. The insertion hole 2821 has a rotating groove 2822 on its wall. The rotating rod 285 includes a rod body 2851 and a rotating block 2852, with the rotating block 2852 integrally connected to one end of the rod body 2851. The rod body 2851 is inserted into the insertion hole 2821, and the rotating block 2852 is inserted into the rotating groove 2822. The rotating block 2852 abuts against the peripheral wall of the rotating groove 2822, and the rod body 2851 abuts against the wall of the insertion hole 2821. A gear ring 286 is fitted onto the rod body 2851 and welded to it. A drive gear 284 meshes with the gear ring 286. A locking block 287 is welded to the end of the rod body 2851 away from the mounting block 282, and the locking block 287 has a locking groove 288.

[0059] First, activate the push-pull cylinder 281 to push the locking block 287 above the shaft 2645. Then, activate the drive motor 283 to rotate the drive rod 2851 and the locking block 287. When the shaft 2645 is engaged in the slot 288, turn off the drive motor 283. Next, activate the lifting cylinder 27 to raise the support plate 263 and the moving frame 264 layer by layer. After the pharmaceutical blanks are placed on all four layers of the frame 2642, activate the drive motor 253 to move the moving frame 264 to the vacuum drying chamber 22. Then, extend the push-pull cylinder 281 to push the moving frame 264 into the vacuum drying chamber 22. Then, rotate the rod 285 in the opposite direction and activate the push-pull cylinder 281 to shorten it. When the locking block 287 slides out of the vacuum drying chamber 22, turn off the vacuum drying chamber 22 to begin vacuum drying. After drying, open the vacuum drying chamber 22, push the locking block 287 into the vacuum drying chamber 22 and engage it with the shaft 2645. Then operate the push-pull cylinder 281 to pull out the moving frame 264. Then start the drive motor 283 to move the moving frame 264 to the medicine blank pulverizer 23, and put the dried medicine blank into the medicine blank pulverizer 23 for pulverization to obtain the ready-to-use medicine powder. While this batch of medicine blanks is drying, start the next moving trolley 25 to place the next batch of medicine blanks on the moving frame 264.

[0060] This embodiment also provides a molding process for preparing traditional Chinese medicine pills, the steps of which are as follows:

[0061] Weigh out 5 kg of styrax, 10 kg of benzoin, 5 kg of borneol, 20 kg of concentrated buffalo horn powder, 7.5 kg of artificial musk, 10 kg of sandalwood, 10 kg of agarwood, 10 kg of cloves, 10 kg of cyperus rotundus, 10 kg of costus root, 10 kg of frankincense (processed), 10 kg of long pepper, 10 kg of atractylodes macrocephala, 10 kg of chebula pulp, and 10 kg of cinnabar.

[0062] Cinnabar is ground into a fine powder using water jet milling. Benzoin is added to the raw material pulverizer 11 and pulverized into a fine powder. The fine powder is then conveyed to the dry material mixer 12. Following the above operation, sandalwood, agarwood, cloves, cyperus rotundus, costus root, frankincense (processed), long pepper, atractylodes macrocephala, chebula pulp, borneol, concentrated buffalo horn powder, and artificial musk are added to the raw material pulverizer 11 in sequence and pulverized into fine powders respectively. All of the above fine powders are added to the dry material mixer 12 and stirred until uniform to obtain a mixed medicinal powder. At the same time, styrax is added to the reaction vessel 13 and heated. After the styrax is melted, the mixed medicinal powder is added to the reaction vessel 13. The mixing agitator 15 is started to stir the materials in the reaction mixture. After uniform mixing, the materials in the reaction vessel 13 are fed into the double-roll calender 14 and calendered into sheets to obtain a medicinal blank with a thickness of 2 mm.

[0063] Then, operate the automatic transfer rack 21 and the shearing piece 16 to place the medicine blank on the automatic transfer rack 21, and then send the medicine blank into the vacuum drying oven 22 for vacuum drying at 25°C. Then, take the dried medicine blank out of the vacuum drying oven 22 and send it into the medicine blank pulverizer 23 to be pulverized into fine powder, thus obtaining the medicine powder for later use.

[0064] Next, weigh out starch and hydroxypropyl cellulose, and add starch, hydroxypropyl cellulose and prepared medicine powder into dry pelleting mechanism 3 in a weight ratio of 1:1:200. Mix evenly and then press into pellets to obtain the original medicine pellets.

[0065] Weigh out 30 kg of polyvinyl alcohol, 5 kg of cross-linked polyvinyl chloride, 2 kg of lubricant, 2 kg of colorant and 2 kg of flavoring agent. Add polyvinyl alcohol, cross-linked polyvinyl chloride, lubricant, colorant and flavoring agent into coating mechanism 4 and mix evenly to obtain coating raw material. Input the original pill into coating mechanism 4 and operate coating mechanism 4 to coat the surface of the original pill with coating raw material. After coating, the traditional Chinese medicine pill is obtained.

[0066] Example 2

[0067] The only difference between this embodiment and Embodiment 1 is that the thickness of the drug blank is 1 mm.

[0068] Example 3

[0069] The only difference between this embodiment and Embodiment 1 is that the thickness of the drug blank is 4 mm.

[0070] Example 4

[0071] The only difference between this embodiment and Embodiment 1 is that the drug blank is vacuum dried at 4°C.

[0072] Example 5

[0073] The only difference between this embodiment and Embodiment 1 is that the drug blank is vacuum dried at 30°C.

[0074] Example 6

[0075] The only difference between this embodiment and Embodiment 1 is that starch, hydroxypropyl cellulose, and the prepared powder are added to the dry pelleting mechanism 3 in a weight ratio of 1:0.8:190.

[0076] Example 7

[0077] The only difference between this embodiment and Embodiment 1 is that starch, hydroxypropyl cellulose, and the prepared powder are added to the dry pelleting mechanism 3 in a weight ratio of 1:1.2:210.

[0078] Comparative Example

[0079] Comparative Example 1

[0080] The only difference between this comparative example and Example 1 is that no coating is applied to the surface of the original pill.

[0081] Comparative Example 2

[0082] The only difference between this comparative example and Example 1 is that an equal amount of honey is used to replace the starch.

[0083] Performance testing

[0084] The following performance tests were conducted on the traditional Chinese medicine pills provided in Examples 1-7 and Comparative Examples 1-2: The traditional Chinese medicine pills provided in Examples 1-7 and Comparative Examples 1-2 were placed in a sterile chamber and kept at a constant temperature of 25°C for 60 days. Afterward, the pills were removed, and the mold content inside the pills was tested according to the "Pharmaceutical Hygiene Standards". The borneol content was determined according to the method described in "Quality Standards of Guanxin Suhe Pill Capsules and Pharmacokinetic Study of Cinnamic Acid". The test results are shown in Table 1.

[0085] Table 1

[0086]

[0087] Combining Example 1 and Comparative Examples 1-2 with Table 1, it can be seen that compared to Example 1, the mold content in Comparative Example 1 is significantly higher, while the borneol content is significantly lower. In contrast, the mold content in Comparative Example 2 is significantly higher, but the borneol content changes less. This indicates that the process described in Example 1 helps improve the preservation effect of traditional Chinese medicine pills and reduces the loss of efficacy due to preservation.

[0088] As can be seen from Examples 1-7 and Table 1, Examples 1-7 all have low mold content and high borneol content. This indicates that under the process conditions of Examples 1-7, the preservation effect of traditional Chinese medicine pills can be improved, while reducing the loss of efficacy caused by preservation.

[0089] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A process for forming traditional Chinese medicine pills, characterized in that, Includes the following steps: Preparation: Weigh out styrax, benzoin, borneol, concentrated buffalo horn powder, artificial musk, sandalwood, agarwood, cloves, cyperus, costus root, prepared frankincense, long pepper, atractylodes macrocephala, chebula pulp, and cinnabar; grind the cinnabar into a fine powder; grind benzoin, sandalwood, agarwood, cloves, cyperus, costus root, prepared frankincense, long pepper, atractylodes macrocephala, chebula pulp, borneol, concentrated buffalo horn powder, and artificial musk into fine powders respectively; mix all the above fine powders to obtain a mixed medicinal powder; stew styrax until dissolved and add it to the mixed medicinal powder, mix evenly, and roll into sheets to obtain a medicinal blank with a thickness of 1-4 mm; Powdering: The raw medicinal material is vacuum dried at 4-30℃, and then pulverized into fine powder to obtain the powder for later use; Dry pill making: Weigh starch and hydroxypropyl cellulose, mix starch, hydroxypropyl cellulose and prepared medicine powder in a weight ratio of 1:(0.8-1.2):(190-210), and then compress into pills to obtain the original medicine pills; Coating: Weigh out polyvinyl alcohol, crospovidone, lubricant, colorant and flavoring agent, mix polyvinyl alcohol, crospovidone, lubricant, colorant and flavoring agent evenly, and coat the surface of the original pill to form a coating, thus obtaining the Chinese medicine pill. The equipment used to implement the above-mentioned traditional Chinese medicine pill forming process includes a blank-making mechanism (1), a powder-making mechanism (2), a dry pelletizing mechanism (3), and a coating mechanism (4). The blank-making mechanism (1) includes a raw material pulverizer (11), a dry material mixer (12), a reaction vessel (13), and a double-roll calender (14) arranged in sequence. The reaction vessel (13) is equipped with a mixing agitator (15), and the double-roll calender (14) is equipped with a shearing component (16). The powder-making mechanism (2) includes an automatic transfer rack (21), a vacuum drying box (22), and a medicine blank pulverizer (23) arranged in sequence. The automatic transfer rack (21) is used to transfer the medicine blank output from the double-roll calender (14) into the vacuum drying box (22). The dry pelletizing mechanism (3) is used to press the spare medicine powder output from the medicine blank pulverizer (23) into raw medicine pills. The coating mechanism (4) is used to coat the raw medicine pills. The automatic transfer rack (21) includes a ring track (24), a moving trolley (25), a drying rack (26), a lifting cylinder (27) for driving the drying rack (26) to rise and fall, and a push-pull component (28) for pushing and pulling the drying rack (26). Several moving trolleys (25) are slidably connected to the ring track (24). The lifting cylinder (27) is located on the moving trolley (25), and the push-pull component (28) is located on the drying rack (26). The lifting cylinder (27) and the push-pull component (28) are both connected to the drying rack (26). The double-roll calender (14), the vacuum drying chamber (22), and the pharmaceutical blank pulverizer (23) are all located on the periphery of the ring track (24). The drying rack (26) includes a base cylinder (261), a slide rod (262), a support plate (263), and a movable frame (264). The base cylinder (261) is fixedly connected to the movable trolley (25). The slide rod (262) is inserted into the base cylinder (261). The support plate (263) is fixedly connected to the slide rod (262). The movable frame (264) is located on the support plate (263). The lifting cylinder (27) is located below the support plate (263). The lifting cylinder (27) is fixedly connected to the support plate (263). The push-pull member (28) is located on the support plate (263). The push-pull member (28) is detachably connected to the movable frame (264). The push-pull component (28) includes a push-pull cylinder (281), a mounting block (282), a drive motor (283), a drive gear (284), a rotating rod (285), a gear ring (286), and a locking block (287). The push-pull cylinder (281) is fixedly connected to the moving trolley (25). The mounting block (282) is fixedly connected to the telescopic end of the push-pull cylinder (281). The drive motor (283) is fixedly connected to the mounting block (282). The drive gear (284) is fixedly connected to the telescopic end of the push-pull cylinder (281). The drive motor (285), gear ring (286), and locking block (287) are also fixedly connected to the moving trolley (25). 84) Fixedly connected to the motor shaft of the drive motor (283), one end of the rotating rod (285) is rotatably connected to the mounting block (282), the other end of the rotating rod (285) is fixedly connected to the locking block (287), the gear ring (286) is sleeved on the rotating rod (285), the gear ring (286) is fixedly connected to the rotating rod (285), the drive gear (284) meshes with the gear ring (286), and the locking block (287) is provided with a locking groove (288).

2. The traditional Chinese medicine pill forming process according to claim 1, characterized in that: The shearing component (16) includes a shearing frame (161), a blade (162), a base plate (163), and a power cylinder (164). The shearing frame (161) is mounted on a twin-roll calender (14). The power cylinder (164) and the base plate (163) are both fixedly connected to the shearing frame (161). The power cylinder (164) is opposite to the base plate (163). The blade (162) is slidably connected to the shearing frame (161). The blade (162) is located between the power cylinder (164) and the base plate (163). The power cylinder (164) and the blade (162) are fixedly connected.

3. The traditional Chinese medicine pill forming process according to claim 1, characterized in that: The movable frame (264) includes a vertical rod (2641), a frame (2642), support bars (2643), ball bearings (2644), a shaft (2645), and a rotating wheel (2646). Several frames (2642) are fixedly connected to the vertical rod (2641) in an upward direction. The vertical rod (2641) is fixedly connected to the shaft (2645). The rotating wheel (2646) is rotatably connected to the end of the shaft (2645). Several support bars (2643) are rotatably connected to the frame (2642), and several rotating wheels (2646) are fixedly connected to the support bars (2643).

4. The traditional Chinese medicine pill forming process according to claim 1, characterized in that: The mobile trolley (25) includes a platform (251), wheels (252), a drive motor (253), a drive gear (254), and abutment wheels (255). The wheels (252), drive motor (253), and abutment wheels (255) are all mounted on the platform (251). The drive gear (254) is fixedly connected to the motor shaft of the drive motor (253). The ring track (24) passes between the drive gear (254) and the abutment wheels (255). The drive gear (254) meshes with the outer peripheral wall of the ring track (24), and the abutment wheels (255) abut against the inner peripheral wall of the ring track (24). The lifting cylinder (27) and the drying rack (26) are both located on the platform (251).

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