A low-temperature penetration-promoting system based on variable-frequency ultrasound

Abstract

The application provides a low-temperature penetration promoting system based on variable-frequency ultrasound, belonging to the field of penetration promotion, and comprising a machine body, a treatment head, a refrigeration component, a first ultrasonic piezoelectric sheet, a second ultrasonic piezoelectric sheet, a third ultrasonic piezoelectric sheet and a microprocessor; the treatment head is provided with a composition to be promoted; the microprocessor is used for applying a driving voltage to the refrigeration component and the three ultrasonic piezoelectric sheets; the refrigeration component is used for reducing the temperature of target skin; the three ultrasonic piezoelectric sheets are respectively used for generating a first ultrasonic signal, a second ultrasonic signal and a third ultrasonic signal with different frequencies and different pulse durations, so as to form transdermal channels with different diameters and different depths at the target skin, and make molecules of different sizes in the composition to be promoted to reach the target points through the transdermal channels. The application can make different sizes of components in the composition to be promoted to reach their effective target points respectively, and reduce the risk of skin sensitivity.

Description

Technical Field

[0001] This invention relates to the field of permeation enhancement, and in particular to a low-temperature permeation enhancement system based on variable frequency ultrasound. Background Technology

[0002] In recent years, with the rise of the "appearance economy" and the improvement of national quality, people are paying more and more attention to makeup and skincare, as well as the texture and scientific basis of skincare products. To respond to the actual needs of the market and users, the efficacy of skincare products has become increasingly refined and diversified, with each ingredient targeting a specific area to exert its effect. Common skincare ingredients like squalane target the sebum film. As a lipid closest to human sebum, squalane can integrate with the sebum film, strengthening and repairing the epidermis. Ceramides target the stratum corneum, replenishing intercellular lipids and repairing the skin barrier, leaving skin soft and radiant. Retinol targets the dermis, inhibiting collagen breakdown and promoting collagen synthesis, thus reducing existing wrinkles and minimizing their formation.

[0003] To ensure skincare ingredients reach their target sites, penetration enhancement is necessary. Currently, existing penetration enhancement methods can be categorized into chemical and physical methods. Chemical penetration enhancement involves adding penetration enhancers to skincare products. These enhancers can be further divided into chemical and herbal penetration enhancers. However, chemical penetration enhancers such as azone, organic acids, and surfactants can cause skin irritation if used in large quantities or for extended periods. Herbal penetration enhancers such as eucalyptus oil, peppermint, and cloves have fewer side effects but lower penetration efficiency. Physical penetration enhancement utilizes physical technologies such as electricity and sound to promote the introduction and absorption of skincare ingredients. This can be categorized into iontophoresis, electroporation, and ultrasound. Iontophoresis uses a continuous low-voltage direct current to apply an electric field to the skin surface. Based on the principle of repulsion between like charges, it applies a driving force to ions or charged skincare ingredients, promoting their penetration into the subcutaneous layer. Iontophoresis requires the ionized skincare ingredients to be ionized, thus having certain limitations and lower penetration efficiency. Electroporation technology involves altering the orientation of lipid molecules in the stratum corneum under a momentary high-voltage pulsed current. This increases the disordered structure of the lipid bilayer, forming hydrophilic pores that enhance cell and tissue membrane permeability. However, it is highly irritating and can negatively impact the skin and the activity of skincare ingredients. It is more suitable for the penetration of small molecules such as chemically synthesized compounds. Ultrasonic infusion utilizes the cavitation effect and microcurrents of ultrasound waves to create temporary, reversible transmission channels in the stratum corneum. The mechanical effect of ultrasound then propels skincare ingredients along the direction of the sound waves, allowing them to penetrate the stratum corneum and reach subcutaneous targets. Compared to iontophoresis and electroporation, ultrasonic infusion does not require ionizable skincare ingredients, and its sound energy is non-invasive and radiation-free, minimizing its impact on the activity of plant-based skincare ingredients. However, current technologies generally use a single-frequency ultrasonic infusion method, opening a single-size penetration channel with each frequency. This approach cannot simultaneously promote the penetration of various ingredients within a skincare product, resulting in lower penetration efficiency. Summary of the Invention

[0004] The purpose of this invention is to provide a low-temperature permeation-enhancing system based on variable frequency ultrasound, which can simultaneously enhance the permeation of molecules of different sizes in a composition, ensuring that molecules of different sizes reach the target sites on the skin and improving the permeation efficiency.

[0005] To achieve the above objectives, the present invention provides the following solution:

[0006] A low-temperature permeation enhancement system based on variable frequency ultrasound includes: a body, a treatment head, a cooling component, a first ultrasonic piezoelectric pad, a second ultrasonic piezoelectric pad, a third ultrasonic piezoelectric pad, and a microprocessor.

[0007] The body is fixedly connected to the treatment head; the treatment head has a composition to be promoted for penetration; the treatment head comes into contact with the target skin when it is working;

[0008] The first ultrasonic piezoelectric pad, the second ultrasonic piezoelectric pad, and the third ultrasonic piezoelectric pad are all disposed on the treatment head;

[0009] The microprocessor is disposed in the body of the machine; the microprocessor is connected to the cooling component, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element and the third ultrasonic piezoelectric element respectively, and the microprocessor is used to apply driving voltage to the cooling component, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element and the third ultrasonic piezoelectric element;

[0010] The cooling component is used to lower the temperature of the target skin;

[0011] The first ultrasonic piezoelectric pad is used to generate a first ultrasonic signal; the second ultrasonic piezoelectric pad is used to generate a second ultrasonic signal; the third ultrasonic piezoelectric pad is used to generate a third ultrasonic signal; the first ultrasonic signal, the second ultrasonic signal, and the third ultrasonic signal are used to form transdermal channels of different diameters and depths at the target skin, so that components of different molecular weights in the composition to be enhanced can reach the target point of action on the target skin through the transdermal channels; wherein, the frequency of the first ultrasonic signal > the frequency of the second ultrasonic signal > the frequency of the third ultrasonic signal, and the pulse duration of the first ultrasonic signal < the pulse duration of the second ultrasonic signal < the pulse duration of the third ultrasonic signal.

[0012] Optionally, the low-temperature permeation-enhancing system based on variable frequency ultrasound further includes:

[0013] A first temperature sensor is disposed on the treatment head for detecting the temperature of the target skin;

[0014] The second temperature sensor is installed inside the machine body and is used to detect the ambient temperature;

[0015] The microprocessor is also connected to the first temperature sensor and the second temperature sensor, and the microprocessor is also used to determine the driving voltage applied to the cooling component based on the temperature of the target skin and the ambient temperature.

[0016] Alternatively, the driving voltage applied to the cooling component can be determined using the following formula:

[0017]

[0018] Among them, U cool T is the driving voltage applied to the cooling component. e For ambient temperature, T f For the target skin temperature, T th A pre-set temperature threshold.

[0019] Optionally, the cooling component includes: a semiconductor cooling chip and a cooling ring structure;

[0020] The cold compress ring structure is disposed on the treatment head;

[0021] The semiconductor cooling chip is disposed in the body of the device and is connected to the microprocessor and the cooling ring structure respectively. The semiconductor cooling chip is used to reduce the temperature of the cooling ring structure under the action of the driving voltage, so as to reduce the temperature of the target skin.

[0022] Optionally, the frequency of the first ultrasonic signal is 1 MHz, the frequency of the second ultrasonic signal is 200 kHz, and the frequency of the third ultrasonic signal is 20 kHz.

[0023] Optionally, the microprocessor is used to apply driving voltages to the cooling component, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element, and the third ultrasonic piezoelectric element in sequence.

[0024] Optionally, the low-temperature permeation-enhancing system based on frequency conversion ultrasound also includes a switching button;

[0025] The switching button is located on the body; the switching button is used to receive switching commands input by the user;

[0026] The microprocessor is also connected to the switching button, and the microprocessor is also used to apply a driving voltage to the cooling component, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element and / or the third ultrasonic piezoelectric element according to the switching command.

[0027] Optionally, the low-temperature permeation-enhancing system based on frequency conversion ultrasound further includes a power amplifier;

[0028] The power amplifier is connected to the microprocessor, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element, and the third ultrasonic piezoelectric element, respectively.

[0029] The microprocessor applies a driving voltage to the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element, and the third ultrasonic piezoelectric element through the power amplifier.

[0030] According to specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0031] This invention controls the intensity of the ultrasonic cavitation effect by changing the frequency of the ultrasonic signal, thereby opening permeation channels of different depths and diameters on the skin barrier. This allows components of different sizes in the permeation-enhancing composition to reach their effective target points. Furthermore, applying a cold compress before the variable frequency ultrasound operation avoids the activation of inflammatory factors and vasodilation in the skin tissue caused by the mechanical and thermal effects of ultrasound, thus reducing the risk of skin sensitivity. Attached Figure Description

[0032] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0033] Figure 1 A schematic diagram of a low-temperature permeation-enhancing system based on variable frequency ultrasound;

[0034] Figure 2 This is a schematic diagram of the treatment head;

[0035] Figure 3 A flowchart illustrating the usage of a low-temperature permeation-enhancing system based on variable frequency ultrasound;

[0036] Figure 4 This is a schematic diagram of the permeation promotion process in four working cycles.

[0037] Symbol explanation:

[0038] Body-1, Treatment head-2, First ultrasonic piezoelectric pad-3, Second ultrasonic piezoelectric pad-4, Third ultrasonic piezoelectric pad-5, Microprocessor-6, Switch button-7, Power amplifier-8, Semiconductor cooling pad-9, Cold compress ring structure-10, First temperature sensor-11, Second temperature sensor-12. Detailed Implementation

[0039] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0040] The purpose of this invention is to provide a low-temperature penetration enhancement system based on variable frequency ultrasound. By changing the working frequency of the ultrasound and the working time of each frequency, the intensity of the ultrasonic cavitation effect can be controlled, thereby opening skin care ingredient penetration channels of different depths and diameters on the skin barrier, so that various skin care ingredients can reach their effective target points.

[0041] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0042] like Figure 1As shown, the present invention provides a low-temperature permeation enhancement system based on frequency conversion ultrasound, comprising: a body 1, a treatment head 2, a cooling component, a first ultrasonic piezoelectric pad 3, a second ultrasonic piezoelectric pad 4, a third ultrasonic piezoelectric pad 5, and a microprocessor 6.

[0043] The body 1 is fixedly connected to the treatment head 2. The treatment head 2 has the composition to be promoted for penetration. The treatment head 2 comes into contact with the target skin during operation.

[0044] The first ultrasonic piezoelectric pad 3, the second ultrasonic piezoelectric pad 4, and the third ultrasonic piezoelectric pad 5 are all disposed on the treatment head 2.

[0045] The microprocessor 6 is disposed within the body 1. The microprocessor 6 is connected to the cooling component, the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and the third ultrasonic piezoelectric element 5, respectively. The microprocessor 6 is used to apply driving voltage to the cooling component, the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and the third ultrasonic piezoelectric element 5.

[0046] In one specific implementation, the microprocessor 6 is used to sequentially apply driving voltages to the cooling component, the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and the third ultrasonic piezoelectric element 5. Specifically, the microprocessor 6 applies driving voltages to the cooling component, the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and the third ultrasonic piezoelectric element 5 sequentially according to a set time period.

[0047] In another specific implementation, the low-temperature permeation-enhancing system based on frequency-modulated ultrasound further includes a switching button 7. The switching button 7 is disposed on the body 1. The switching button 7 is used to receive a switching command input by the user. The microprocessor 6 is also connected to the switching button 7, and the microprocessor 6 is further used to apply a driving voltage to the cooling component, the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and / or the third ultrasonic piezoelectric element 5 according to the switching command.

[0048] Furthermore, the low-temperature permeation-enhancing system based on frequency-conversion ultrasound also includes a power amplifier 8. The power amplifier 8 is connected to the microprocessor 6, the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and the third ultrasonic piezoelectric element 5, respectively. The microprocessor 6 applies a driving voltage to the first ultrasonic piezoelectric element 3, the second ultrasonic piezoelectric element 4, and the third ultrasonic piezoelectric element 5 through the power amplifier 8.

[0049] The cooling component is used to lower the temperature of the target skin. In this embodiment, the cooling component includes a semiconductor cooling pad 9 and a cooling ring structure 10. The cooling ring structure 10 is disposed on the treatment head 2. The semiconductor cooling pad 9 is disposed inside the body 1 and is connected to both the microprocessor 6 and the cooling ring structure 10. The semiconductor cooling pad 9 is used to lower the temperature of the cooling ring structure 10 under the action of the driving voltage, thereby lowering the temperature of the target skin.

[0050] The first ultrasonic piezoelectric pad 3 is used to generate a first ultrasonic signal. The second ultrasonic piezoelectric pad 4 is used to generate a second ultrasonic signal. The third ultrasonic piezoelectric pad 5 is used to generate a third ultrasonic signal. The first, second, and third ultrasonic signals are used to form transdermal channels of different diameters and depths at the target skin, allowing components of different molecular weights in the composition to be enhanced to reach the target site of the target skin through the transdermal channels. The frequency of the first ultrasonic signal > the frequency of the second ultrasonic signal > the frequency of the third ultrasonic signal, and the pulse duration of the first ultrasonic signal < the pulse duration of the second ultrasonic signal < the pulse duration of the third ultrasonic signal.

[0051] Specifically, the first ultrasound signal interacts with the composition to be enhanced to produce a cavitation effect. The cavitation bubbles break open the skin barrier, forming the shallowest and smallest transdermal channel, allowing the smaller molecular weight components to reach their subcutaneous target sites.

[0052] The second ultrasound signal interacts with the composition to be enhanced to produce a cavitation effect. The cavitation bubbles break open the skin barrier, forming a transdermal channel with a medium penetration depth and diameter, allowing the medium molecular weight component to reach its subcutaneous target.

[0053] The third ultrasound signal interacts with the composition to be enhanced to generate a sonic micro-flow, which opens the skin barrier by cavitation bubble rupture, forming the deepest and largest transdermal channel, allowing the component with the largest molecular weight to reach its subcutaneous target.

[0054] Because the three frequencies open transdermal channels to different depths, the duration of the ultrasound signal pulses at the three frequencies should meet the following requirements: h <p m <p l Among them, p h p is the pulse duration of the first ultrasound signal. m p is the pulse duration of the second ultrasound signal. l The pulse duration of the third ultrasound signal.

[0055] The molecular weight of the component in the penetration-enhancing composition that acts at shallow, intermediate, and deep depths should meet the requirement of D. h≤D m ≤D l Among them, D h D represents the molecular weight of the component that promotes permeation by the first ultrasound signal. m D represents the molecular weight of the component that promotes permeation via the second ultrasound signal. l The molecular weight of the component that promotes permeation by the third ultrasound signal.

[0056] In one specific implementation, the frequency of the first ultrasonic signal is 1MHz, the frequency of the second ultrasonic signal is 200kHz, and the frequency of the third ultrasonic signal is 20kHz.

[0057] To improve the accuracy of temperature control for the target skin, the low-temperature permeation-enhancing system based on variable frequency ultrasound further includes a first temperature sensor 11 and a second temperature sensor 12. The first temperature sensor 11 is disposed on the treatment head 2 and is used to detect the temperature of the target skin. The second temperature sensor 12 is disposed inside the body 1 and is used to detect the ambient temperature.

[0058] The microprocessor 6 is also connected to the first temperature sensor 11 and the second temperature sensor 12. The microprocessor 6 is further configured to determine the driving voltage applied to the cooling component based on the temperature of the target skin and the ambient temperature. Specifically, the driving voltage applied to the cooling component is determined using the following formula:

[0059]

[0060] Among them, U cool T is the driving voltage applied to the cooling component. e For ambient temperature, T f For the target skin temperature, T th The preset temperature threshold, i.e. the temperature threshold for cold compress therapy, has an initial value of 12℃. Users can manually set it according to their experience with cold compress therapy.

[0061] Furthermore, the present invention can be applied to the field of beauty, and the penetration-enhancing composition can be different types of skin care products to improve the beauty effect.

[0062] The higher the ultrasound frequency, the narrower the transdermal channel diameter; the longer the pulse duration, the deeper the transdermal channel. Skincare ingredients can only pass through the transdermal channel when its diameter is larger than the molecular weight; and skincare ingredients can only reach the target site and exert their effects when the depth of the transdermal channel is greater than the depth of the target site. By adjusting the ultrasound frequency to control the diameter of the transdermal channel, various ingredients with different molecular weights in skincare products can pass through the skin barrier sequentially. By adjusting the pulse duration of different ultrasound frequencies to control the depth of the transdermal channel, skincare ingredients can reach the subcutaneous target site sequentially.

[0063] On the one hand, this invention controls the intensity of the ultrasonic cavitation effect by changing the ultrasonic working frequency and the working time of each frequency, thereby opening skin care ingredient penetration channels of different depths and diameters on the skin barrier, so that various skin care ingredients can reach their effective target points respectively; on the other hand, cold compress treatment is performed before the variable frequency ultrasound is operated, which avoids the activation of inflammatory factors and vasodilation in skin tissue caused by the mechanical and thermal effects of ultrasound, and reduces the risk of skin sensitivity.

[0064] To better understand the solution of this invention, the usage process of the low-temperature permeation-enhancing system based on frequency conversion ultrasound is described below with reference to specific embodiments, such as... Figure 3 As shown.

[0065] Step 1: The user places an appropriate amount of skincare product on the treatment head. After the system is turned on, the user holds the ultrasonic treatment head, ensuring it is in close contact with the facial skin. The entire treatment process is divided into 4 work cycles, with a full-face treatment performed in each cycle. The transdermal channels created by ultrasonic cavitation are transient and reversible. Each full-face treatment cycle needs to be maintained for a period of time. This means that by the current work cycle, the transdermal channels opened in the previous work cycle tend to close, preventing skincare ingredients from reaching the wrong target areas.

[0066] Step 2: The user presses the switch button on the handle for the first time to put the system into the first working cycle, and performs cold compress and massage treatment on the whole face by sliding the treatment head.

[0067] The cold compress treatment process is as follows: the microprocessor applies a driving voltage U to the semiconductor cooling chip. cool The cold end of the thermoelectric cooler connects to the ring-shaped portion on the treatment head, lowering the head's temperature and allowing the user to apply a cooling treatment to the entire face. Because the ultrasonic treatment head is made of metal, to ensure a better cooling experience, a 50V driving voltage is applied to the thermoelectric cooler when the temperature difference between the ambient environment and the target skin is less than a temperature threshold, initiating the cooling process. When the temperature difference is greater than or equal to the temperature threshold, the driving voltage is no longer applied, and the cooling process stops.

[0068] The massage treatment process involves the user sliding the treatment head to evenly apply skincare products to the entire face. During this process, the skincare ingredients that target the skin barrier and stratum corneum fully contact the skin of the entire face to exert their effects.

[0069] This invention combines ultrasound penetration enhancement with cold compress function, and sets the cold compress function in the first working cycle, which effectively avoids the activation of inflammatory factors and vasodilation in skin tissue caused by the mechanical and thermal effects of ultrasound in the subsequent three cycles, thus reducing the risk of skin sensitivity.

[0070] Step 3: The user presses the switch button on the handle a second time to put the system into the second working cycle, and performs high-frequency ultrasound penetration-enhancing treatment on the entire face by sliding the treatment head:

[0071] The microprocessor applies a driving voltage to the high-frequency ultrasonic piezoelectric element (the first ultrasonic piezoelectric element) through a power amplifier. The high-frequency ultrasonic piezoelectric element converts electrical signals into acoustic signals. The high-frequency ultrasonic signal (the first ultrasonic signal) interacts with the skin care product to generate a cavitation effect. The cavitation bubbles break open the skin barrier, forming the shallowest and smallest transdermal channel, allowing the skin care ingredients with smaller molecular weights to reach their subcutaneous target sites.

[0072] The frequency of the high-frequency ultrasound signal is f. h =1MHz, pulse duration is p h The diameter of the transdermal channel formed under high-frequency ultrasound is d. h Depth is l h The molecular weight of the skincare ingredient that uses high-frequency ultrasound signals to enhance penetration is D. h The depth d of its subcutaneous target point t,h It should satisfy 0≤d t,h ≤l h .

[0073] Step 4: The user presses the switch button on the handle for the third time to put the system into the third working cycle, and performs mid-frequency ultrasound penetration enhancement treatment on the whole face by sliding the treatment head:

[0074] The microprocessor applies a driving voltage to the intermediate frequency ultrasonic piezoelectric element (second ultrasonic piezoelectric element) through a power amplifier. The intermediate frequency ultrasonic piezoelectric element converts electrical signals into acoustic signals. The intermediate frequency ultrasonic signal (second ultrasonic signal) interacts with the skin care product to generate a cavitation effect. The cavitation bubbles break open the skin barrier, forming a transdermal channel with a medium penetration depth and diameter, allowing skin care ingredients with medium molecular weight to reach their subcutaneous target sites.

[0075] The frequency of the intermediate frequency ultrasound signal is f. m =800kHz, pulse duration is p m The diameter of the transdermal channel formed under the action of mid-frequency ultrasound is d. m Depth is l m The molecular weight of the skincare ingredient that uses mid-frequency ultrasound signals to enhance penetration is D. m The depth d of its subcutaneous target point t,m Should satisfy l h ≤d t,m ≤l m .

[0076] Step 5: The user presses the switch button on the handle for the fourth time to put the system into its fourth working cycle, performing low-frequency ultrasound penetration-enhancing treatment on the entire face by sliding the treatment head.

[0077] The microprocessor applies a driving voltage to the low-frequency ultrasonic piezoelectric element (the third ultrasonic piezoelectric element) through a power amplifier. The low-frequency ultrasonic piezoelectric element converts electrical signals into acoustic signals. The low-frequency ultrasonic signal (the third ultrasonic signal) interacts with the skin care product to generate a sound wave micro-impact. The cavitation bubble breaks open the skin barrier, forming the deepest and largest transdermal channel, allowing the skin care ingredients with the largest molecular weight to reach their subcutaneous target.

[0078] The frequency of the low-frequency ultrasound signal is f. l =200kHz, pulse duration is p l The diameter of the transdermal channel formed under low-frequency ultrasound is d. l Depth is l l The molecular weight of the skincare ingredient that uses low-frequency ultrasound signals to enhance penetration is D. l The depth d of its subcutaneous target point t,l Should satisfy l m ≤d t,l ≤l l .like Figure 4 The diagram shows the permeation process over four working cycles.

[0079] Step 6: End of treatment.

[0080] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the system and core ideas of the present invention. Furthermore, those skilled in the art will recognize that, based on the ideas of the present invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A low-temperature permeation-enhancing system based on variable frequency ultrasound, characterized in that, The low-temperature permeation enhancement system based on frequency conversion ultrasound includes: a body, a treatment head, a cooling component, a first ultrasonic piezoelectric pad, a second ultrasonic piezoelectric pad, a third ultrasonic piezoelectric pad, and a microprocessor. The body is fixedly connected to the treatment head; the treatment head has the composition to be promoted for penetration; the treatment head comes into contact with the target skin when it is working; The first ultrasonic piezoelectric pad, the second ultrasonic piezoelectric pad, and the third ultrasonic piezoelectric pad are all disposed on the treatment head; The microprocessor is disposed in the body of the machine; the microprocessor is connected to the cooling component, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element and the third ultrasonic piezoelectric element respectively, and the microprocessor is used to apply driving voltage to the cooling component, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element and the third ultrasonic piezoelectric element in sequence according to a set time period; The cooling component is used to lower the temperature of the target skin; the cooling component includes: a semiconductor cooling pad and a cooling ring structure; the cooling ring structure is disposed on the treatment head; the semiconductor cooling pad is disposed in the body of the device and is respectively connected to the microprocessor and the cooling ring structure, and the semiconductor cooling pad is used to lower the temperature of the cooling ring structure under the action of the driving voltage, so as to lower the temperature of the target skin; The first ultrasonic piezoelectric pad is used to generate a first ultrasonic signal; the second ultrasonic piezoelectric pad is used to generate a second ultrasonic signal; the third ultrasonic piezoelectric pad is used to generate a third ultrasonic signal; the first ultrasonic signal, the second ultrasonic signal, and the third ultrasonic signal are used to form transdermal channels of different diameters and depths at the target skin, so that components of different molecular weights in the composition to be enhanced can reach the target point of action on the target skin through the transdermal channels; wherein, the frequency of the first ultrasonic signal > the frequency of the second ultrasonic signal > the frequency of the third ultrasonic signal, and the pulse duration of the first ultrasonic signal < the pulse duration of the second ultrasonic signal < the pulse duration of the third ultrasonic signal.

2. The low-temperature permeation-enhancing system based on variable frequency ultrasound according to claim 1, characterized in that, The low-temperature permeation-enhancing system based on variable frequency ultrasound also includes: A first temperature sensor is disposed on the treatment head for detecting the temperature of the target skin; The second temperature sensor is installed inside the machine body and is used to detect the ambient temperature; The microprocessor is also connected to the first temperature sensor and the second temperature sensor, and the microprocessor is also used to determine the driving voltage applied to the cooling component based on the temperature of the target skin and the ambient temperature.

3. The low-temperature permeation-enhancing system based on variable frequency ultrasound according to claim 2, characterized in that, The driving voltage applied to the cooling component is determined using the following formula: ； in, U cool The driving voltage applied to the cooling component. T e For ambient temperature, T f The temperature of the target skin. T th A pre-set temperature threshold.

4. The low-temperature permeation-enhancing system based on variable frequency ultrasound according to claim 1, characterized in that, The frequency of the first ultrasonic signal is 1MHz, the frequency of the second ultrasonic signal is 200kHz, and the frequency of the third ultrasonic signal is 20kHz.

5. The low-temperature permeation-enhancing system based on variable frequency ultrasound according to claim 1, characterized in that, The low-temperature permeation-enhancing system based on frequency conversion ultrasound also includes a power amplifier; The power amplifier is connected to the microprocessor, the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element, and the third ultrasonic piezoelectric element, respectively. The microprocessor applies a driving voltage to the first ultrasonic piezoelectric element, the second ultrasonic piezoelectric element, and the third ultrasonic piezoelectric element through the power amplifier.

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