A pressure-sensible brain stereotaxic apparatus

Abstract

The application discloses a pressure-sensible brain stereotaxic apparatus and belongs to the technical field of medical research and medical equipment. The brain stereotaxic apparatus comprises a bottom plate, a rotating assembly and a marking assembly. The bottom plate is provided with a fixing device for fixing the head of an animal. The rotating assembly comprises a vertically movable base plate, a rotating disc rotatably connected with the base plate and a rotating unit. The rotating disc is provided with a groove. The rotating unit comprises a gear ring coaxially connected with the rotating disc and a gear rack. The gear rack is in mesh with the gear ring and is slidably connected with the base plate. The gear rack can drive the rotating disc to rotate by 180 DEG. The marking assembly comprises a pressure sensing unit and a skull drill and a skull needle. The pressure sensing unit is installed on the groove. The skull drill and the skull needle are coaxially arranged at two ends of the pressure sensing unit. The pressure sensing unit can sense the pressure change of the skull drill or the skull needle. The rotating disc can drive the skull drill or the skull needle to be vertically arranged downward. The application can accurately identify the contact between the skull needle and the furnace body.

Description

Technical Field

[0001] This invention relates to the field of medical research and medical equipment technology, and in particular to a pressure-sensitive stereotaxic device for the brain. Background Technology

[0002] The brain is the most complex organ in the human body, and unraveling its mysteries is considered the "ultimate frontier" of life science research. To date, brain science research has made a series of significant advances at both the microscopic and macroscopic levels. In fact, the brain's structure and function are highly complex, requiring the use of certain tools and techniques to better study it. Stereotactic brain imaging technology provides a powerful tool for brain science research.

[0003] The invention disclosed in CN111888036B is a fixing structure for a stereotaxic instrument for rats and mice. It uses a lead screw to rotate and drive a slider to move on the control panel, which facilitates precise adjustment of the position of the two ear rods, thereby achieving the effect of blocking the ear canals of rats and mice. The adjustment accuracy is high and the ear rods will not puncture the eardrums of rats and mice.

[0004] The invention disclosed in CN112807122B is a positioning arm with a cranial drill, comprising: a cranial drill and a positioning and fixing component for positioning; wherein, the positioning and fixing component is provided with a retractable connecting sleeve; the cranial drill is detachably connected to the positioning and fixing component by being fitted into and secured by the connecting sleeve. This positioning arm allows for direct drilling after positioning during experimental surgery on mouse and rat heads, without the need to remove the positioning arm or manually mark the area, making the entire process convenient, accurate, and rapid; it is also simple to operate, effectively shortening the surgical positioning and drilling time; and it is highly versatile, compatible with most commercially available stereotaxic instruments for mouse and rat brains.

[0005] In existing stereotaxic devices, after drilling a hole in the skull, a syringe is used to inject the needle into the skull for positioning. However, inaccurate positioning is prone to occur when determining the zero point of the Z-axis. During actual positioning, it may appear to the naked eye that the syringe has touched the skull, but in reality, it has not, or because the skull has some elasticity, it has actually descended to the point where there is a slight indentation in the skull. Summary of the Invention

[0006] In view of this, it is necessary to provide a pressure-sensitive stereotaxic instrument to solve the problem that existing stereotaxic instruments have difficulty in determining the zero point of the Z-axis.

[0007] This invention provides a pressure-sensitive stereotaxic device, comprising:

[0008] A base plate, on which a fixing device for fixing the animal's head can be provided;

[0009] A rotating assembly includes a vertically movable base plate, a rotating disk rotatably connected to the base plate, and a rotating unit. The rotating disk has a groove. The rotating unit includes a gear ring and a rack coaxially connected to the rotating disk. The rack meshes with the gear ring and is slidably connected to the base plate. The rack can drive the rotating disk to rotate 180°.

[0010] The marking assembly includes a pressure sensing unit, a skull drill, and a skull needle. The pressure sensing unit is mounted on the groove. The skull drill and skull needle are coaxially arranged and located at both ends of the pressure sensing unit. The pressure sensing unit can sense pressure changes of the skull drill or skull needle.

[0011] The rotating disk can drive the skull drill or skull needle to be set vertically downward.

[0012] In some embodiments, the pressure sensing unit includes a sleeve detachably connected to the groove and a pressure sensor. The pressure sensor is disposed in the middle of the sleeve and fixedly connected to the sleeve. The ends of the skull drill and skull needle are respectively inserted into the sleeve from both ends and abut against the pressure sensor.

[0013] In some embodiments, the ends of the skull drill and skull needle are respectively connected to the sleeve via a transition fit, and friction grease is provided between the ends of the skull drill and skull needle and the sleeve.

[0014] In some embodiments, a sliding unit is provided between the rack and the substrate. The sliding unit includes a guide rail fixedly connected to the substrate, a sliding frame slidably engaged with the guide rail, and a limiting member. The rack is mounted on the sliding frame, and the limiting member is disposed on both sides of the substrate to limit the movement range of the sliding frame.

[0015] In some embodiments, a hollow groove is provided in the middle of the sliding frame, and the rotating disk is disposed in the hollow groove.

[0016] In some embodiments, a fastening bolt is provided on one side of the sliding frame, and the fastening bolt abuts against the guide rail through the sliding frame to lock the sliding frame.

[0017] In some embodiments, the cranial needle is a microinjector.

[0018] In some embodiments, a driving assembly is further included, the driving assembly including a vertical driving unit and a horizontal driving unit disposed parallel to the substrate, the horizontal driving unit being connected to the vertical driving unit, the horizontal driving unit being capable of driving the vertical driving unit to move relative to both sides of the substrate, the substrate being connected to the vertical driving unit, and the vertical driving unit being capable of driving the substrate to move vertically.

[0019] In some embodiments, a support is also included, and the vertical drive unit is fixedly connected to the support via the horizontal drive unit, wherein the horizontal drive unit is capable of driving the vertical drive unit to move relative to the support.

[0020] In some embodiments, the driving assembly further includes a longitudinal driving unit, the base plate is connected to the support via the longitudinal driving unit, and the longitudinal driving unit is capable of driving the base plate to move in a direction perpendicular to the substrate.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0022] (1) The present invention provides a pressure-sensitive stereotaxic device for the brain, comprising a rotating unit, which includes a gear ring and a rack coaxially connected to a rotating disk. The rack meshes with the gear ring and is slidably connected to a base plate. By precisely controlling the stroke of the rack, the rack can drive the rotating disk to rotate 180°, which can respectively drive the cranial drill or cranial needle to be vertically downward. After the cranial drill drills a hole in the skull, there is no need to disassemble the cranial drill and then install the cranial needle. The rotating disk rotates 180°, directly adjusting the cranial needle, which is coaxially set with the cranial drill, to be vertically downward. This simplifies the test steps, improves the test accuracy, and ensures that the cranial needle can be accurately inserted into the hole drilled by the cranial drill. This avoids the cranial needle from being misaligned with the hole due to various errors, resulting in inaccurate positioning or even damage to the cranial needle.

[0023] (2) A pressure-sensitive stereotaxic device for brain positioning according to the present invention is provided with a marking component. The marking component includes a pressure sensing unit, a cranial drill and a cranial needle. The pressure sensing unit is installed on a groove. The cranial drill and the cranial needle are coaxially arranged and located at both ends of the pressure sensing unit. When the external pressure on the cranial drill or the cranial needle changes slightly, the pressure sensing unit can identify it in real time, thereby determining that the cranial needle is in contact with the skull and accurately determining the zero point of the Z-axis, which is convenient for subsequent brain science research. Attached Figure Description

[0024] The accompanying drawings, which are included to provide a further understanding of the invention and form part of this application, illustrate exemplary embodiments of the invention and, together with their description, serve to explain the invention and do not constitute an undue limitation thereof. In the drawings:

[0025] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0026] Figure 2 This is a schematic diagram of the sliding unit and marking component in this invention;

[0027] Figure 3 This is a schematic diagram of the marking component in this invention;

[0028] Figure 4 This is a schematic diagram of the sliding frame in the first extreme position in this invention;

[0029] Figure 5 This is a schematic diagram of the sliding frame in the second extreme position in this invention;

[0030] Figure 6 This is a schematic diagram of the connection structure between the support and the marking assembly in this invention;

[0031] Figure 7 This is a brain region scan of the mouse used in this invention;

[0032] In the figure, there are: base plate 100, rotating assembly 200, base plate 210, rotating disk 220, groove 221, rotating unit 230, gear ring 231, rack 232, sliding unit 240, guide rail 241, sliding frame 242, limiting component 243, hollow groove 244, fastening bolt 245, marking assembly 300, pressure sensing unit 310, sleeve 311, pressure sensor 312, skull drill 320, skull needle 330, driving assembly 400, vertical driving unit 410, horizontal driving unit 420, longitudinal driving unit 430, and support 500. Detailed Implementation

[0033] Preferred embodiments of the present invention will now be described in detail with reference to the accompanying drawings, which form part of this application and are used together with the embodiments of the present invention to illustrate the principles of the present invention, but are not intended to limit the scope of the present invention.

[0034] This embodiment describes a pressure-sensitive stereotaxic device for the brain, relating to the fields of medical research and medical device technology. It is applied to animal brain region experiments and can be used for experiments on mammals such as mice, birds such as birds, or fish such as carp. In this application, mice are used as the experimental animal, but the device is not limited to mice. The stereotaxic device in this application can accurately measure the slight pressure between the cranial needle 330 and the skull, thereby accurately determining the zero point of the Z-axis.

[0035] Please see Figures 1 to 6 A pressure-sensitive stereotaxic device in this embodiment includes: a base plate 100, a rotating assembly 200, and a marking assembly 300, wherein:

[0036] The base plate 100 can be equipped with a fixing device for fixing the animal's head. The fixing device can be selected as needed to clamp the head of different experimental animals.

[0037] The rotating assembly 200 includes a base plate 210, a rotating disk 220, and a rotating unit 230. The base plate 210 serves as a carrier and can move vertically, thereby driving other components to move relative to the base plate 100 to perform drilling and injection operations on the animal's skull.

[0038] The rotating disk 220 is rotatably connected to the substrate 210. The rotating disk 220 can rotate freely relative to the substrate 210. A groove 221 is provided on the rotating disk 220. The groove 221 can be used to install the skull drill 320 and the skull needle 330.

[0039] The rotating unit 230 includes a gear ring 231 and a rack 232 coaxially connected to the rotating disk 220. The rack 232 meshes with the gear ring 231 and is slidably connected to the base plate 210. By precisely controlling the stroke of the rack 232, the rack 232 can drive the rotating disk 220 to achieve a 180° rotation, thereby completely reversing the orientation of the groove 221.

[0040] The marking component 300 includes a pressure sensing unit 310, a cranial drill 320, and a cranial needle 330. The pressure sensing unit 310 is mounted on the groove 221. The cranial drill 320 and the cranial needle 330 are coaxially arranged and located at both ends of the pressure sensing unit 310. When the external pressure on the cranial drill 320 or the cranial needle 330 changes slightly, the pressure sensing unit 310 can identify it in real time, thereby determining that the cranial needle 330 is in contact with the skull, accurately determining the zero point of the Z-axis, which is convenient for subsequent neuroscience research.

[0041] The rotating disk 220 can drive the cranial drill 320 or the cranial needle 330 to be vertically downwards. After the cranial drill 320 drills a hole in the skull, there is no need to disassemble the cranial drill 320 to install the cranial needle 330. The rotating disk 220 rotates 180° to directly adjust the cranial needle 330, which is coaxial with the cranial drill 320, to be vertically downwards. This simplifies the test procedure, improves the test accuracy, and ensures that the cranial needle 330 can be accurately inserted into the hole drilled by the cranial drill 320. This avoids inaccurate positioning or even damage to the cranial needle 330 due to various errors causing it to be out of concentricity with the hole.

[0042] Please see Figure 2 and Figure 3The pressure sensing unit 310 includes a sleeve 311 and a pressure sensor 312. The sleeve 311 is detachably connected to the groove 221. In some embodiments, the sleeve 311 is directly snapped into the groove 221, and the two sides of the groove 221 press against the sleeve 311 to fix the sleeve 311 in the rotating disk 220. In some embodiments, screw holes can be opened on both sides of the groove 221, and screws can be screwed into the screw holes to effectively fix the sleeve 311 installed in the groove 221.

[0043] A pressure sensor 312 is located in the middle of the sleeve 311 and is fixedly connected to the sleeve 311. The pressure sensor 312 is also fixedly connected to the inner wall of the sleeve 311. The ends of the skull drill 320 and skull needle 330 are respectively inserted into the sleeve 311 from both ends and abut against the pressure sensor 312. When the skull drill 320 or skull needle 330 is subjected to a reaction force from the skull, the pressure sensor 312 can sensitively identify and display the specific resistance force value. The operator can adjust the drilling pressure and determine the zero point of the Z-axis based on the value.

[0044] In some embodiments, please refer to Figure 3 The ends of the cranial drill 320 and the cranial needle 330 are respectively connected to the sleeve 311 with a transition fit. The end of the cranial drill 320 away from the drill bit is inserted into the sleeve 311 and is connected to the sleeve 311 with a transition fit to maintain the corresponding friction and ensure that the cranial drill 320 will not come out of the sleeve 311. At the same time, the end of the cranial needle 330 away from the needle tip is inserted into the sleeve 311 and is connected to the sleeve 311 with a transition fit to maintain the corresponding friction and ensure that the cranial drill 320 will not come out of the sleeve 311.

[0045] It should be noted that friction grease is provided between the ends of the cranial drill 320 and cranial needle 330 and the sleeve 311. This friction grease enhances the friction between the cranial drill 320 and cranial needle 330 and the inner wall of the sleeve 311, preventing the cranial drill 320 and cranial needle 330 from dislodging. Furthermore, the drill bit of the cranial drill 320 and the needle bit of the cranial needle 330 are coaxially positioned in the middle, ensuring accurate positioning during switching.

[0046] In some embodiments, please refer to Figure 2 A sliding unit 240 is provided between the rack 232 and the substrate 210. The sliding unit 240 includes a guide rail 241 fixedly connected to the substrate 210, a sliding frame 242 slidably engaged with the guide rail 241, and a limiting member 243. The cross-section of the guide rail 241 can be T-shaped, trapezoidal, or dovetail-shaped. A corresponding sliding groove is provided at the bottom of the sliding frame 242. The sliding groove can be slidably engaged with the guide rail 241. The sliding frame 242 can move along the guide rail 241 in a defined direction.

[0047] In a further embodiment, the rack 232 is mounted on the sliding frame 242, which can drive the rack 232 to move, thereby pushing the gear ring 231 to rotate, and ultimately driving the rotation of the rotating disk 220. Furthermore, by providing limiting members 243 on both sides of the base plate 210, the distance between the limiting members 243 and the sliding frame 242 can be adjusted, thereby precisely controlling the rotation angle of the gear ring 231 and the rotating disk 220, allowing the rotating disk 220 to achieve 180° rotation and switching.

[0048] Please continue reading. Figure 2 A fastening bolt 245 is provided on one side of the sliding frame 242. A screw hole is provided on the sliding frame 242. The fastening bolt 245 is screwed into the screw hole. The fastening bolt 245 passes through the screw hole and abuts against the guide rail 241, thereby locking the sliding frame 242 and ensuring that the sliding frame 242 remains stationary relative to the guide rail 241.

[0049] As a preferred embodiment, the sliding frame 242 has two extreme positions on the guide rail 241.

[0050] Please see Figure 4 In the first extreme position, the right side of the sliding frame 242 abuts against the right-side limiting member 243, and the cranial needle 330 and cranial drill 320 remain vertically set. The drill bit of the cranial drill 320 is set vertically downward. The sliding frame 242 is locked by the fastening bolt 245, and the cranial drill 320 can drill holes in the skull.

[0051] Please see Figure 5 In the second extreme position, the left side of the sliding frame 242 abuts against the left-side limiting member 243, and the cranial needle 330 and cranial drill 320 remain vertically positioned, with the tip of the cranial needle 330 pointing vertically downwards. The sliding frame 242 is locked in place using the fastening bolt 245, allowing the cranial needle 330 to mark the skull.

[0052] The movement of the sliding frame 242 between its two extreme positions can drive the rotating disk 220 to switch 180°, thereby enabling the use of the cranial needle 330 and the cranial drill 320 respectively.

[0053] In some embodiments, the cranial needle 330 is a micro-injector with a maximum injection volume of 10 μL.

[0054] Please see Figure 6A pressure-sensitive stereotaxic device further includes a drive assembly 400, which includes a vertical drive unit 410 and a horizontal drive unit 420 arranged parallel to the substrate 210. The horizontal drive unit 420 is connected to the vertical drive unit 410 and can drive the vertical drive unit 410 to move relative to both sides of the substrate 210. The substrate 210 is connected to the vertical drive unit 410 and can drive the substrate 210 to move vertically.

[0055] In practical implementation, the vertical drive unit 410 includes a vertically arranged screw, a guide rod, and a nut. Support plates are provided at both ends of the guide rod and the screw. One end of the nut is screwed to the screw, and the nut is slidably connected to the guide rod. Rotating the screw moves the nut. The nut is fixedly connected to the base plate 210, which can move vertically under the action of the vertical drive unit 410.

[0056] Similarly, the horizontal drive unit 420 has a similar structure to the vertical drive unit 410. The screw of the horizontal drive unit 420 is arranged perpendicular to the screw of the vertical drive unit 410 and parallel to the substrate 210. The nut of the horizontal drive unit 420 is fixedly connected to the support plate in the vertical drive unit 410, thereby realizing the overall drive of the vertical drive unit 410.

[0057] A pressure-sensitive stereotaxic device further includes a support 500, which includes a base and two oppositely spaced side plates, the side plates being perpendicular to and fixedly connected to the base. A support plate of a horizontal drive unit 420 is fixedly connected to the side plates, and the horizontal drive unit 420 can drive a vertical drive unit 410 to move relative to the support 500.

[0058] The drive assembly 400 also includes a longitudinal drive unit 430, which has a structure similar to that of the vertical drive unit 410. The screw of the longitudinal drive unit 430 is arranged perpendicular to the substrate 210, the nut of the longitudinal drive unit 430 is fixedly connected to the base plate 100, and the support plate of the longitudinal drive unit 430 is fixedly connected to the base. The longitudinal drive unit 430 can drive the base plate 100 to move in a direction perpendicular to the substrate 210.

[0059] The horizontal drive unit 420 and the vertical drive unit 410 cooperate to move the cranial drill 320 and cranial needle 330 in a vertical plane parallel to the base plate 210, thereby positioning the various functional areas of the skull. The vertical drive unit 430 is set independently relative to the horizontal drive unit 420 and the vertical drive unit 410, which allows the fixation device used to fix the animal's head to move with the base plate 100, escaping the frontal shadow of the rotating component 200. This facilitates the operation of the experimental animal by the staff over a larger range and avoids interference from the marking component 300 and the rotating component 200.

[0060] It should be noted that the screws of the horizontal drive unit 420, the vertical drive unit 410, and the longitudinal drive unit 430 can be coaxially connected to a servo motor for driving. Alternatively, a handwheel can be installed at the end of the screw for manual operation.

[0061] Workflow: Weigh the laboratory mice, anesthetize them, and prepare the skin on their heads. Disinfect with 75% alcohol.

[0062] 1. Fix the anesthetized mouse to the fixation device on the base plate 100. The specific operation is as follows: Insert the mouse's upper incisors into the horizontal bar, and adjust the knob to press the nose bar firmly; insert the ear bar into the mouse's ear canal, and adjust the left and right ear bars to make the line connecting the two ears of the mouse and the ear bars in a straight line. After ensuring that the scale positions of the left and right ear bars are the same, adjust the knob to lock the ear bars. The criteria for judging whether the mouse is well fixed are: nose aligned with the center, head not moving, tail not falling off, and the brain visually placed horizontally (making the skull horizontal).

[0063] 2. Use ophthalmic scissors to make a longitudinal incision of about 3 cm in the mouse's head skin. Use forceps to peel off and remove the periosteal connective tissue along the surface of the skull. Use a sterile cotton ball to remove the oozing blood, clean the surface of the skull, and expose the anterior and posterior fontanelles.

[0064] Third, first activate the longitudinal drive unit 430, move the base plate 100 directly below the marking component 300, and adjust the horizontal drive unit 420. Move the sliding frame 242 to the first extreme position and lock the sliding frame 242. Adjust the horizontal drive unit 420 so that the drill bit of the skull drill 320 is at a predetermined position on the mouse's head. Adjust the vertical drive unit 410 so that the drill bit is close to the mouse's head. Monitor the resistance pressure through the pressure sensor 312 to ensure that the drill bit drills to a predetermined depth on the mouse's head with a predetermined resistance pressure.

[0065] Please see Figure 7During localization, the skull must first be aligned horizontally to determine the Bregma site. Then, the target site is located using the corresponding coordinates on a brain atlas. For the skull to be aligned horizontally, both the Bregma and Lambda sites must be on the same horizontal plane, and the left and right hemispheres must be symmetrical on the same horizontal plane. The injection coordinates vary depending on the injection site and the mouse's weight. The location of the nucleus to be localized is determined by consulting a stereotaxic brain atlas, and the coordinate values ​​are calculated as ML (X-axis), AP (Y-axis), and DV (Z-axis).

[0066] 5. Adjust the sliding frame 242 to the second extreme position, with the cranial needle 330 set vertically downwards. The position of the cranial needle 330 is the same as when drilling the hole previously. Adjust the vertical drive unit 410 to insert the needle tip of the micro-cranial needle 330 into the target nucleus. Perform a slow injection; the injection dosage depends on the specific experiment. After injection, leave the needle in place for 10 minutes to allow for full absorption of the medication. Slowly adjust the Z-axis knob upwards to pull out the needle, and apply bone wax to the drilled area.

[0067] 6. Suture the skin and complete the stereotactic injection into the brain.

[0068] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in the present invention should be included within the scope of the present invention.

Claims

1. A pressure-sensible brain stereotaxic apparatus, characterized by, The utility model relates to a kind of animal head fixing device, including: Bottom plate, the fixing device for fixing animal head can be set on the bottom plate; Rotary assembly, the rotary assembly includes vertically movable base plate, rotary disc and rotation unit connected with base plate, the rotary disc is equipped with groove;The rotation unit includes gear ring coaxially connected with the rotary disc and rack, the rack is engaged with the gear ring and is slidably connected with the base plate, the rack can drive the rotary disc to realize 180 ° rotation;Slip unit is equipped between the rack and the base plate, the slip unit includes guide rail fixedly connected with the base plate, sliding frame body slidably connected with guide rail and limiting piece, the rack is installed on the sliding frame body, the limiting piece is arranged on both sides of the base plate to limit the movement range of the sliding frame body; Marking assembly, the marking assembly includes pressure sensing unit and skull drill and skull needle, the pressure sensing unit is installed on the groove, the skull drill and skull needle are coaxially arranged and are arranged at both ends of the pressure sensing unit, the pressure sensing unit can sense the pressure change of the skull drill or skull needle;The pressure sensing unit includes sleeve and pressure sensor, the pressure sensor is arranged in the middle of the sleeve and is fixedly connected with the sleeve, the end of the skull drill and skull needle is respectively inserted into the sleeve from both ends and abuts against the pressure sensor; Drive assembly, the drive assembly includes vertical drive unit and horizontal drive unit arranged parallel to the base plate, the horizontal drive unit is connected with the vertical drive unit, the horizontal drive unit can drive the vertical drive unit to move relative to both sides of the base plate, the base plate is connected with the vertical drive unit, and the vertical drive unit can drive the base plate to move vertically; The rotary disc can drive the skull drill or skull needle to be arranged vertically downward.

2. A pressure-sensible brain stereotaxic apparatus according to claim 1, wherein The end of the skull drill and skull needle is connected with the sleeve in transition fit, and friction grease is arranged between the end of the skull drill and skull needle and the sleeve.

3. A pressure-sensible brain stereotaxic apparatus according to claim 1, wherein The middle of the sliding frame body is provided with a hollow groove, and the rotary disc is arranged in the hollow groove.

4. A pressure-sensible brain stereotaxic instrument according to claim 3, characterized in that, One side of the sliding frame body is provided with a fastening bolt, the fastening bolt abuts against the guide rail through the sliding frame body to lock the sliding frame body.

5. A pressure-sensible brain stereotaxic instrument according to claim 1, characterized in that, The skull needle is a microsyringe.

6. A pressure-sensible brain stereotaxic instrument according to claim 1, characterized in that, The vertical drive unit is fixedly connected with the support through the horizontal drive unit, and the horizontal drive unit can drive the vertical drive unit to move relative to the support.

7. A pressure-sensible brain stereotaxic instrument according to claim 6, characterized in that, The drive assembly further includes a longitudinal drive unit, and the bottom plate is connected with the support through the longitudinal drive unit, and the longitudinal drive unit can drive the bottom plate to move in a direction perpendicular to the base plate.

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