Composition for assisting weight loss and preparation method thereof

Abstract

The present invention relates to a composition for assisting weight loss and a preparation method thereof. The formula of the composition for assisting weight loss includes the following raw material components: 80-100 parts of guar gum, 1-5 parts of malic acid, 10-15 parts of inulin, and 5-10 parts of potato extract. The present invention forms a super absorbent hydrogel with a three-dimensional structure by cross-linking guar gum and malic acid, which absorbs water and swells to occupy the volume of the stomach, reducing the daily food intake; inulin can increase the viscosity of the stomach contents and reduce the speed at which food enters the small intestine from the stomach; the protease inhibitor of the potato extract can effectively increase the leptin content in the plasma, thereby delaying the emptying of the contents in the stomach, and can transmit a satiety signal to the brain, reduce appetite, and effectively reduce food intake. The composition for assisting weight loss of the present invention can be eaten 20-30 minutes before a meal, provides a sense of satiety before a meal, reduces appetite, does not affect the user's three meals a day, and achieves the purpose of weight loss by reducing the amount of food intake per meal.

Description

Technical Field

[0001] The invention relates to a composition for assisting weight loss and a preparation method thereof. Background Art

[0002] In 2018-2019, the overweight / obese rate among adults in my country was 51.2%. Some scholars have evaluated the prevalence of overweight / obesity in my country based on linear regression analysis of national data, and used data analysis methods to predict future development trends. By 2030, the overall prevalence of overweight / obesity among adults in my country may reach 70.5%. At present, the health burden caused by obesity in my country is very high, and this situation may deteriorate sharply in the future. Active intervention measures are urgently needed to combat the growing obesity epidemic. Today's weight loss products are mostly based on traditional Chinese medicine formulas, which may cause adverse reactions if taken for a long time; or in the form of meal replacements, the ingredients are complex and diverse, and the daily consumption of meal replacements prevents obese people from eating their favorite foods, and users cannot persist for a long time.

[0003] Chinese patent application 202011208201.2 discloses a hydrogel that assists in controlling diet, and its preparation method and application. The invention uses sodium carboxymethyl cellulose, water-soluble polysaccharide polymers and polycarboxylic acids as raw materials, and conducts a cross-linking reaction to obtain a hydrogel with a high swelling ratio in the acidic environment of the stomach, which occupies the stomach space by swelling with water. This patent application controls diet by physically occupying the stomach space to reduce the stomach capacity. After the hydrogel has absorbed water and expanded, the higher the swelling ratio, the better the fluidity, the shorter the retention time in the stomach, the faster the emptying speed, and the time to produce a feeling of fullness is limited. Moreover, by simply occupying the space in the stomach, the user will still have the desire to eat, and the appetite is not suppressed, so it is difficult for obese people to persist in using it.

[0004] Chinese patent application 202110450935.X discloses a composition for weight control, its preparation method and application. The raw materials in the patent application include Ganoderma lucidum residue, oatmeal, rye kernel, quinoa, black rice, buckwheat, corn husk and black sesame. The patent application contains up to 8 ingredients, mainly cellulose and coarse grains, which are single and unattractive. After eating the meal replacement, the user cannot eat three meals a day normally, and it is difficult for obese people to stick to it.

[0005] Chinese patent application 2023100616046 discloses a Chinese medicine formula for weight loss and its production process. The drug raw materials in the patent application include: Poria, Poria, Atractylodes macrocephala, Magnolia officinalis, Alisma orientalis, Cinnamomum cassia, Citrus aurantium, and Licorice. The main ingredients in the patent application are Chinese medicine ingredients. Long-term consumption of Chinese medicine may have potential adverse reactions. At the same time, different obese patients have different fat-making mechanisms. Only through the effects of strengthening the spleen and removing dampness, diuresis and relieving stranguria, and warming yang and transforming qi, it may not be effective for all obese patients. Users are not very accepting and cannot persist in long-term use.

[0006] In summary, the above patent applications generally have shortcomings such as complex ingredients, cannot be consumed for a long time, users cannot persist in using them, and affect the normal consumption of three meals a day.

[0007] Therefore, the market is in urgent need of developing a weight loss product with simple ingredients and preparation method, which does not affect the normal three meals a day of obese people, and allows obese people to take it for a long time without adverse effects. Summary of the invention

[0008] In view of the above-mentioned defects of the prior art, the present invention provides a composition for assisting weight loss. The product has simple ingredients and preparation method, does not affect the normal eating of obese people for three meals a day, and allows obese people to take it for a long time without adverse effects.

[0009] The technical objectives of the present invention are achieved through the following technical solutions:

[0010] The present invention provides a composition for assisting weight loss, and the formula thereof comprises the following raw material components by weight: 80-100 parts of guar gum, 1-5 parts of malic acid, 10-15 parts of inulin, and 5-10 parts of potato extract. Guar gum and malic acid are cross-linked to form a super absorbent hydrogel with a three-dimensional structure, which absorbs water and swells to occupy the volume of the stomach, thereby reducing the stomach capacity. Inulin increases the viscosity of the stomach contents and reduces the speed at which food enters the small intestine from the stomach. Inulin can also be used as a prebiotic by beneficial microorganisms in the colon, thereby improving the intestinal environment and promoting weight loss. Potato extract: protease inhibitors present in potatoes can effectively increase the leptin content in plasma, thereby delaying the emptying of the contents in the stomach, and can transmit satiety signals to the brain, reduce appetite, and enable people to effectively reduce food intake.

[0011] Preferably, the formula of the present invention further comprises the following raw material components: 100 parts of guar gum, 5 parts of malic acid, 15 parts of inulin, and 5 parts of potato extract.

[0012] Preferably, the formula of the present invention further comprises the following raw material components: 90 parts of guar gum, 3 parts of malic acid, 12 parts of inulin, and 8 parts of potato extract.

[0013] Preferably, the formula of the present invention further comprises the following raw material components: 80 parts of guar gum, 1 part of malic acid, 15 parts of inulin, and 10 parts of potato extract.

[0014] Furthermore, the formula of the present invention also includes water in an amount of 15-25 times the weight of the guar gum and the malic acid.

[0015] Furthermore, the viscosity of the guar gum of the present invention is 4500-6000 mPa·s.

[0016] Furthermore, the inulin of the present invention is obtained by spray drying with chicory root as raw material, and has an inulin content of ≥90% and a polymerization degree of 10-20.

[0017] Another technical object of the present invention is to provide a method for preparing the above-mentioned composition for assisting weight loss, comprising the following steps:

[0018] 1) dissolving malic acid in water to obtain a solution;

[0019] 2) adding guar gum to the solution under stirring conditions, stirring evenly until completely dissolved, to obtain micelles;

[0020] 3) drying and cross-linking the micelles, crushing them, and mixing them with inulin and potato extract to obtain the micelles.

[0021] Furthermore, the drying and cross-linking process of the present invention is carried out at a temperature of 65-85° C. and for a time of 12-18 hours.

[0022] Furthermore, the pulverization requirement of the present invention is that it needs to pass through an 80-mesh sieve.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The weight loss-aiding composition of the present invention has multiple weight loss effects: guar gum and malic acid are cross-linked to form a highly absorbent three-dimensional hydrogel that physically occupies the stomach, and inulin prolongs the viscosity of the absorbent hydrogel in the stomach to prolong its retention time in the stomach, prolong gastric emptying time, and prolong the time of satiety. In addition, the protease inhibitor II (PI2) of potato extract suppresses appetite, and multiple mechanisms are superimposed to enhance the weight loss effect;

[0025] 2. The weight loss-aiding composition of the present invention does not affect the regular meals, and is conducive to long-term use by dieters. The most difficult thing for dieters to lose weight is persistence. The present invention provides a sense of fullness before meals, reduces appetite, does not affect the three meals a day of the user, and the user can still eat some of his favorite foods normally, but only reduces the daily food intake of the dieter to one-third or one-half of the previous amount, thereby achieving the purpose of weight loss, which is conducive to the dieter's persistence in use. DETAILED DESCRIPTION

[0026] In order to better illustrate the technical purpose, technical scheme and advantages of the present invention, the present invention is further described in conjunction with specific embodiments. The raw materials used in the present invention are guar gum, malic acid, inulin, and potato extract (all of which are conventionally sold products in the market. The unit of weight parts mentioned in the present invention is gram.

[0027] Example 1

[0028] By weight, the raw material components used in the weight loss assisting composition of Example 1 include: 100 parts of guar gum, 5 parts of malic acid, 15 parts of inulin, and 5 parts of potato extract.

[0029] The preparation method of the composition for assisting weight loss of this embodiment comprises the following steps:

[0030] 1) dissolving malic acid in 1575 parts of pure water to obtain a solution;

[0031] 2) adding guar gum while stirring the solution, and then stirring until the guar gum is completely dissolved and uniformly dissolved to obtain micelles;

[0032] 3) drying the micelle at 85° C. for 12 h to allow a cross-linking reaction to occur;

[0033] 4) drying and cross-linking the micelles, breaking the walls and pulverizing them through an 80-mesh sieve, and mixing them with inulin and potato extract to obtain the weight-loss composition.

[0034] Control group 1A

[0035] The formula of the auxiliary weight loss composition of the control group 1A does not contain guar gum, and only adds malic acid, inulin, and potato extract as three raw material components prepared according to the proportions of Example 1.

[0036] The preparation method of the weight loss-aiding composition of the control group 1A comprises the following steps:

[0037] The malic acid is dissolved in 1575 parts of pure water to obtain a solution; and the solution is mixed with inulin and potato extract to obtain the weight loss composition.

[0038] Control group 1B

[0039] The auxiliary weight loss composition of the control group 1B was formulated without malic acid and only contained three raw material components, namely, guar gum, inulin and potato extract, to obtain the auxiliary weight loss composition of the control group 1A.

[0040] The preparation method of the composition for assisting weight loss in the control group 1B comprises the following steps:

[0041] 1) dissolving guar gum in 1575 parts of pure water, and then stirring until the guar gum is completely dissolved and uniformly dissolved to obtain micelles;

[0042] 2) drying the micelle at 85° C. for 12 h to allow a cross-linking reaction to occur;

[0043] 3) drying and cross-linking the micelles, breaking the walls and pulverizing them through an 80-mesh sieve, and mixing them with inulin and potato extract to obtain the weight-loss composition.

[0044] Example 2

[0045] By weight, the raw material components used in the weight loss auxiliary composition of this embodiment include: 90 parts of guar gum, 3 parts of malic acid, 12 parts of inulin, and 8 parts of potato extract.

[0046] The preparation method of the composition for assisting weight loss of this embodiment comprises the following steps:

[0047] 1) dissolving malic acid in 1860 parts of pure water to obtain a solution;

[0048] 2) adding guar gum while stirring the solution, and then stirring until the guar gum is completely dissolved and uniformly dissolved to obtain micelles;

[0049] 3) drying the micelle at 75° C. for 15 h to allow a cross-linking reaction to occur;

[0050] 4) drying and cross-linking the micelles, breaking the walls and pulverizing them through an 80-mesh sieve, and mixing them with inulin and potato extract to obtain the weight-loss composition.

[0051] Control group 2A

[0052] The auxiliary weight loss composition of the control group 2A does not contain guar gum, and only contains three raw material components, namely, malic acid, inulin and potato extract, and is prepared according to the proportions of Example 2.

[0053] The preparation method of the composition for assisting weight loss of the control group 2A comprises the following steps:

[0054] Dissolve malic acid in 1860 parts of pure water to obtain a solution; mix well with inulin and potato extract to obtain a solution.

[0055] Control group 2B

[0056] The auxiliary weight loss composition of the control group 2B does not contain malic acid, but only contains guar gum, inulin and potato extract, and is prepared according to the proportions of Example 2.

[0057] The preparation method of the weight loss-aiding composition of the control group 2B comprises the following steps:

[0058] 1) dissolving guar gum in 1860 parts of pure water, and then stirring until the guar gum is completely dissolved and uniformly dissolved to obtain micelles;

[0059] 2) drying the micelle at 75° C. for 15 h to allow a cross-linking reaction to occur;

[0060] 3) drying and cross-linking the micelles, breaking the walls and pulverizing them through an 80-mesh sieve, and mixing them with inulin and potato extract to obtain the weight-loss composition.

[0061] Example 3

[0062] By weight, the raw material components used in the weight loss auxiliary composition of this embodiment include: 80 parts of guar gum, 1 part of malic acid, 15 parts of inulin, and 10 parts of potato extract.

[0063] The preparation method of the composition for assisting weight loss of this embodiment comprises the following steps:

[0064] 1) dissolving malic acid in 2025 parts of pure water to obtain a solution;

[0065] 2) adding guar gum while stirring the solution, and then stirring until the guar gum is completely dissolved and uniformly dissolved to obtain micelles;

[0066] 3) drying the micelle at 65° C. for 18 h to allow a cross-linking reaction to occur;

[0067] 4) drying and cross-linking the micelles, breaking the walls and pulverizing them through an 80-mesh sieve, and mixing them with inulin and potato extract to obtain the weight-loss composition.

[0068] Control group 3A

[0069] The auxiliary weight loss composition of the control group 3A did not contain guar gum, but only added malic acid, inulin and potato extract, and was prepared according to the proportions of Example 3.

[0070] The preparation method of the weight loss-aiding composition of the control group 3A comprises the following steps:

[0071] The malic acid is dissolved in 2025 parts of pure water, and mixed with inulin and potato extract to obtain the weight loss composition.

[0072] Control group 3B

[0073] The auxiliary weight loss composition of the control group 3B did not contain malic acid, but only added guar gum, inulin and potato extract, and was prepared according to the proportions of Example 3.

[0074] The preparation method of the weight loss-aiding composition of the control group 3B comprises the following steps:

[0075] 1) dissolving guar gum in 2025 parts of pure water, stirring until the guar gum is completely dissolved and uniformly dissolved to obtain micelles;

[0076] 2) drying the micelle at 65° C. for 18 h to allow a cross-linking reaction to occur;

[0077] 3) drying and cross-linking the micelles, breaking the walls and pulverizing them through an 80-mesh sieve, and mixing them with inulin and potato extract to obtain the weight-loss composition.

[0078] 2. Efficacy Test

[0079] 1. Efficacy test 1

[0080] 9 obese patients with weight loss needs (without other diseases and normal appetite, and similar weight) were recruited and randomly divided into three groups: control group 1A, control group 1B and experimental group 1. The auxiliary weight loss composition of experimental group 1 was prepared according to Example 1 of the present invention; each patient took 4 g of the corresponding weight loss product each time, before lunch and dinner every day (lunch and dinner for each obese patient were uniformly prepared, with the same meal size and dishes), that is, took it twice a day, and the weight changes of each group of patients for 4 weeks were recorded. The results are shown in Table 1 below:

[0081] Table 1 Body weight change test results of efficacy test 1

[0082] Patient (weight / kg) Day 0 Week 1 Week 2 Week 3 Week 4 Control group 1A 63.8±5.92 64.2±6 64±6.12 63.9±5.79 64.4±6.04 Control group 1B 67.7±6.71 67.9±6.83 67.6±6.77 68.3±7 68.4±7.19 Experimental Group 1 63.1±6.65 60.3±6.13 59.9±6.42 58.3±5.71 57.1±5.59

[0083] 2. Efficacy test 2

[0084] 9 obese patients with weight loss needs (without other diseases and normal appetite, and similar weight) were recruited and randomly divided into three groups: control group 2A, control group 2B and experimental group 2. The auxiliary weight loss composition of experimental group 2 was prepared according to Example 2 of the present invention; each patient took 4 g of the corresponding weight loss product each time, before lunch and dinner every day (lunch and dinner for each obese patient were uniformly prepared, with the same meal size and dishes), that is, took it twice a day, and the weight changes of each group of patients for 4 weeks were recorded. The results are shown in Table 2 below:

[0085] Weight change test results of efficacy trial 2

[0086] Patient (weight / kg) Day 0 Week 1 Week 2 Week 3 Week 4 Control group 2A 73.5±8.21 73.4±7.99 73.8±8.11 74.2±8.21 74.4±8.09 Control group 1B 75.3±7.7 75.2±7.45 74.9±7.32 75.1±7.87 75.3±7.56 Experimental Group 2 75.4±6.89 72.3±7.01 70.6±6.71 69.2±6.55 67.5±6.35

[0087] 3. Efficacy test 3

[0088] 9 obese patients with weight loss needs (without other diseases and normal appetite, and similar weight) were recruited and randomly divided into three groups: control group 3A, control group 3B and experimental group 3. The auxiliary weight loss composition of experimental group 3 was prepared according to Example 3 of the present invention; each patient took 4 g of the corresponding weight loss product each time, before lunch and dinner every day (lunch and dinner for each obese patient were uniformly prepared, with the same meal size and dishes), that is, took it twice a day, and recorded the weight changes of each group of patients for 4 weeks. The results are shown in Table 3 below:

[0089] Table 3 Body weight change test results of efficacy test 3

[0090] Patient (weight / kg) Day 0 Week 1 Week 2 Week 3 Week 4 Control group 3A 78.8±7.77 78.2±7.56 78.6±7.43 79.1±7.61 78.4±7.83 Control group 3B 75.3±7.38 75.2±7.26 76.4±7.21 76.7±7.09 76.1±7.42 Experimental Group 3 77.1±6.78 75.2±6.66 73.6±6.45 72.4±6.09 70.3±6.44

[0091] It can be seen from the data in Tables 1 to 3 that the weight of the patients in experimental groups 1, 2, and 3 has decreased significantly, and the weight loss is obvious; by the end of the fourth week of weight loss, the weight loss rate of each patient reached 8.5% to 12%. It can be seen that the weight loss-aiding composition described in Examples 1 to 3 has a significant effect on the weight loss of obese patients. However, the weight change of obese patients in all control groups was not obvious, and some patients even had a slight increase in weight in the fourth week, indicating that the formula of the weight loss-aiding composition of the present invention is scientific, and guar gum, malic acid, inulin and potato extract are all crucial and indispensable, forming a synergistic effect with each other. The above embodiments are only used to illustrate the technical scheme of the present invention rather than to limit the scope of protection of the present invention. In addition, the present invention can also be implemented in other ways. Although the present invention is described in detail with reference to the above embodiments, ordinary technicians in the field should understand that the technical scheme of the present invention can be modified or equivalently replaced, but these modifications or replacements are within the scope of protection of the present invention.

Claims

1. A composition for assisting weight loss, characterized in that: The invention is prepared from the following raw materials by weight: 80-100 parts of guar gum, 1-5 parts of malic acid, 10-15 parts of inulin and 5-10 parts of potato extract; the viscosity of the guar gum is 4500-6000 mPa·s; the inulin is obtained by spray drying with chicory root as raw material, the inulin content is ≥90%, and the degree of polymerization is 10-20.

2. The composition for assisting weight loss according to claim 1, characterized in that: 100 parts of guar gum, 5 parts of malic acid, 15 parts of inulin, and 5 parts of potato extract.

3. The composition for assisting weight loss according to claim 1, characterized in that: 90 parts of guar gum, 3 parts of malic acid, 12 parts of inulin, and 8 parts of potato extract.

4. The composition for assisting weight loss according to claim 1, characterized in that: 80 parts of guar gum, 1 part of malic acid, 15 parts of inulin, and 10 parts of potato extract.

5. A method for preparing a composition for assisting weight loss as claimed in any one of claims 1 to 4, characterized in that: The following steps are involved: 1) dissolving malic acid in water to obtain a solution; 2) adding guar gum to the solution under stirring conditions, stirring evenly until completely dissolved, to obtain micelles; 3) drying and cross-linking the micelles, crushing them, and mixing them with inulin and potato extract to obtain the micelles.

6. The method for preparing the composition for assisting weight loss according to claim 5, characterized in that: The drying and cross-linking temperature is 65-85°C and the time is 12-18 hours.

7. The method for preparing the composition for assisting weight loss according to claim 5, characterized in that: The particle size of the crushed material is required to pass through an 80-mesh sieve.