A compound composition containing python oil for treating hemorrhoids and preparation method thereof

Abstract

The present invention provides a composite composition containing python oil for treating hemorrhoids and a preparation method thereof, the composite composition comprising the following raw materials in parts by weight: 50-70 parts of python oil extract, 15-25 parts of peach gum, 15-25 parts of chitosan, 11-14 parts of menthol, 13-18 parts of borneol, 4-8 parts of sanguisorba officinalis extract, 11-15 parts of phellodendron, 5-9 parts of gallnut, 7-10 parts of angelica dahurica, 7-8 parts of dragon's blood, 3-6 parts of aloe gel, 5-10 parts of sodium gamma-polyglutamate, 8-15 parts of ethylhexyl palmitate, and 4-8 parts of phytosterol. The composite composition of the present invention has a synergistic effect, can play a role in rapid anti-inflammatory, antipruritic, analgesic and hemostatic effects, relieves symptoms such as swelling, pain and bleeding of hemorrhoids, effectively promotes the healing of hemorrhoid wounds, and improves the therapeutic effect.

Description

Technical Field

[0001] The invention relates to the field of hemorrhoid medicines, and in particular to a compound composition containing python oil for treating hemorrhoids and a preparation method thereof. Background Art

[0002] Hemorrhoids are common and multiple anorectal diseases. Hemorrhoids are also called hemorrhoids or hemorrhoids. It is mainly caused by the enlargement and tortuosity of the veins under the skin of the anal margin, the anal canal or the lower rectal mucosa, which forms venous masses, leading to local ulcers. The main symptoms of hemorrhoids are itching, pain, edema and prolapse around the anus, which may be accompanied by blood in the stool, and the disease is repeated, causing a lot of inconvenience and pain to the patient's life. At present, there are oral medication and topical medication in the treatment of hemorrhoids. The topical method can act directly on the site of the disease, so it has a quick effect and good medication effect, but most topical Western medicines contain hormones or simple Chinese medicines that are slow to take effect, resulting in unstable treatment effects, repeated attacks of hemorrhoids, and poor treatment effects. Summary of the invention

[0003] In view of this, the present invention provides a composite composition containing python oil for treating hemorrhoids and a preparation method thereof.

[0004] The technical solution of the present invention is achieved in this way:

[0005] A python oil-containing compound composition for treating hemorrhoids comprises the following raw materials in parts by weight: 50-70 parts of python oil extract, 15-25 parts of peach gum, 15-25 parts of chitosan, 11-14 parts of menthol, 13-18 parts of borneol, 4-8 parts of sanguisorba officinalis extract, 11-15 parts of phellodendron amurense, 5-9 parts of gallnut, 7-10 parts of angelica dahurica, 7-8 parts of dragon's blood, 3-6 parts of aloe gel, 5-10 parts of sodium gamma-polyglutamate, 8-15 parts of ethylhexyl palmitate and 4-8 parts of phytosterol.

[0006] Furthermore, the python oil-containing compound composition for treating hemorrhoids comprises the following raw materials in parts by weight: 55 parts of python oil extract, 23 parts of peach gum, 19 parts of chitosan, 13 parts of menthol, 16 parts of borneol, 5 parts of Sanguisorba officinalis extract, 12 parts of Phellodendron amurense, 6 parts of Galla chinensis, 9 parts of Angelica dahurica, 7 parts of Dragon's Blood, 4 parts of aloe gel, 8 parts of sodium γ-polyglutamate, 12 parts of ethylhexyl palmitate, and 6 parts of phytosterols.

[0007] Furthermore, the preparation method of the python oil extract is: peeling fat from the abdomen of the python, removing impurities and film on the surface of the fat, placing it in an oil refining pot, refining it at a temperature of 85-105°C, filtering to remove impurities, and cooling to obtain the python oil extract.

[0008] Furthermore, the preparation method of the Sanguisorba officinalis extract is: crush the Sanguisorba officinalis, add 3 to 4 times the weight of water to boil for 3 to 4 hours, filter out the medicinal liquid, add 6 to 8 times the weight of water to the residue and boil for 5 to 6 hours, filter out the medicinal liquid, and discard the residue; combine the two medicinal liquids and evaporate to dryness to obtain the Sanguisorba officinalis extract.

[0009] Furthermore, the phytosterols include one or a combination of two or more of β-sitosterol, stigmasterol, campesterol and brassicasterol.

[0010] A method for preparing a composite composition containing python oil for treating hemorrhoids comprises the following steps:

[0011] Step 1: crush peach gum and add it to distilled water while stirring to obtain a peach gum solution; add chitosan to ascorbic acid solution to obtain a chitosan solution; add python oil extract to the peach gum solution and perform high-speed shear treatment, and then add the chitosan solution and perform low-speed shear treatment to obtain composite raw material A;

[0012] Step 2: grind and crush Phellodendron amurense, Galla chinensis, and Angelica dahurica, soak them in distilled water, and then perform ultrasonic treatment. Filter and obtain the medicinal solution. Add distilled water to the medicinal residues for ultrasonic treatment. Repeat 2 to 3 times, then combine the filtrate, and concentrate to a water content of 40 to 50% to obtain a mixed solution.

[0013] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterols for high-pressure homogenization, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2 for high-pressure homogenization again, and then adding menthol, borneol, Sanguisorba officinalis extract, Dragon's Blood, and sodium γ-polyglutamate for high-pressure homogenization to obtain a composite composition containing python oil.

[0014] Furthermore, in step one, the mass concentration of peach gum in the peach gum solution is 20-30%; in step two, the distilled water is 4-6 times the total amount of Phellodendron amurense, Galla chinensis and Angelica dahurica.

[0015] Furthermore, the ascorbic acid solution is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:50-60, adding ascorbic acid to distilled water and stirring evenly to obtain the ascorbic acid solution.

[0016] Furthermore, in step 1, the rotation speed of the high-speed shearing is 5000-8000 r / min, the temperature is 30-35°C, and the time is 4-8 min; the rotation speed of the low-speed shearing is 400-600 r / min, the temperature is 40-50°C, and the time is 6-10 min.

[0017] Furthermore, in step 2, the ultrasonic treatment power is 500-700w, the temperature is 40-60°C, and the time is 30-40min.

[0018] Furthermore, in step three, the pressure of the high-pressure homogenization is 50-80 MPa, and the pressure holding time is 20-45 min.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] 1. The compound composition for treating hemorrhoids in the present invention is mainly python oil, which contains abundant natural active substances and antibacterial ingredients, and has the effects of antibacterial and anti-inflammatory, hemostasis and analgesia, decomposition and granulation, and promotion of wound healing; menthol has a cooling and antipruritic effect; Phellodendron has the effects of detoxification, purging fire, clearing heat and drying dampness; Galla chinensis has the effects of collecting moisture and astringing sores, astringing intestines and stopping diarrhea, stopping bleeding, and astringing the lungs and reducing fire; Angelica dahurica has the effects of reducing swelling and pus, dispelling wind and relieving pain; Sanguisorba officinalis has the effects of promoting granulation and astringing sores, removing blood stasis and stopping bleeding, and promoting blood circulation and relieving pain; Aloe vera gel has the effects of activating cell vitality, harmonizing skin, and astringing; and phytosterol has the effects of anti-inflammatory and antiviral. The synergistic effect of python oil with peach gum, chitosan, sanguisorba officinalis extract, Phellodendron, Galla chinensis, Angelica dahurica, Sanguisorba officinalis, aloe vera gel, etc. can play a role of rapid anti-inflammatory, antipruritic, analgesic and hemostatic effects, relieve the symptoms of hemorrhoids such as swelling, pain, and bleeding, effectively promote the healing of hemorrhoid wounds, and improve the therapeutic effect.

[0021] 2. Through the preparation method of the present invention, the compound composition is prepared into a stable emulsion with super strong permeability and strong affinity for skin and mucous membranes, so that the active ingredients in the compound composition of the present invention take effect on hemorrhoids quickly, and at the same time have a long action time and good therapeutic effect.

[0022] 3. In the preparation process of the present application, peach gum, python oil and chitosan solution are first compounded. Peach gum has negative charge and chitosan has positive charge. Under the action of positive and negative charges, cross-linked gel molecules are formed to wrap the python oil, so that the python oil can form a stable microemulsion and reduce the fishy smell of the python oil. In addition, peach gum and chitosan also have the effects of promoting wound healing and inhibiting bacteria, and can also reduce inflammation in the hemorrhoid area. Under the action of aloe vera gel, phytosterols and sodium polyglutamate, cell proliferation can be promoted, hemorrhoid wound healing can be promoted, and the treatment effect can be improved. DETAILED DESCRIPTION

[0023] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0024] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0025] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0026] The preparation method of the python oil extract comprises the following steps: removing fat from the abdomen of the python, removing impurities and a film on the surface of the fat, placing the fat in an oil refining pot, refining the fat at a temperature of 85-105° C., filtering and removing impurities, and cooling the fat to obtain the python oil extract.

[0027] Example 1

[0028] The composite composition containing python oil for treating hemorrhoids of the present embodiment comprises the following raw materials in parts by weight: 50 parts of python oil extract, 15 parts of peach gum, 15 parts of chitosan, 11 parts of menthol, 13 parts of borneol, 4 parts of Sanguisorba officinalis extract, 11 parts of Phellodendron amurense, 5 parts of Galla chinensis, 7 parts of Angelica dahurica, 7 parts of Dragon's Blood, 3 parts of aloe gel, 5 parts of sodium γ-polyglutamate, 8 parts of ethylhexyl palmitate, and 4 parts of phytosterol composed of β-sitosterol, stigmasterol, campesterol and rapeseed sterol in a mass ratio of 1:1:1:1;

[0029] The preparation method of the Sanguisorba officinalis extract in this embodiment is as follows: grind Sanguisorba officinalis, add 3 times the weight of water to boil for 3 hours, filter out the liquid, add 6 times the weight of water to the residue and boil for 5 hours, filter out the liquid, and discard the residue; combine the two liquids and evaporate to dryness to obtain the Sanguisorba officinalis extract;

[0030] The ascorbic acid solution in this embodiment is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:50, adding ascorbic acid to the distilled water and stirring evenly to obtain an ascorbic acid solution;

[0031] The preparation method of the compound composition comprises the following steps:

[0032] Step 1: crush peach gum and add it into distilled water while stirring to obtain a peach gum solution with a mass concentration of 20%; add chitosan into ascorbic acid solution to obtain a chitosan solution; add python oil extract into the peach gum solution and perform high-speed shear treatment at a speed of 5000r / min and a temperature of 30°C for 4 minutes, then add chitosan solution and perform low-speed shear treatment at a speed of 400r / min and a temperature of 40°C for 6 minutes to obtain composite raw material A;

[0033] Step 2: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 4 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica, soak them, and then ultrasonically treat them at a power of 500w and a temperature of 40°C for 30min, filter and obtain the liquid medicine, add distilled water to the residue, and ultrasonically treat them at a power of 500w and a temperature of 40°C for 30min, repeat the filtration treatment 2-3 times, combine the filtrate, and concentrate it to a water content of 40% to obtain a mixed solution;

[0034] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterol, and performing high-pressure homogenization at a pressure of 50 MPa for 20 minutes, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2, and performing high-pressure homogenization at a pressure of 50 MPa for 20 minutes, and then adding menthol, borneol, Sanguisorba officinalis extract, Sanguisorba officinalis, and sodium γ-polyglutamate, and performing high-pressure homogenization at a pressure of 50 MPa for 20 minutes, to obtain a composite composition containing python oil.

[0035] Example 2

[0036] The composite composition containing python oil for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 70 parts of python oil extract, 25 parts of peach gum, 25 parts of chitosan, 14 parts of menthol, 18 parts of borneol, 8 parts of Sanguisorba officinalis extract, 15 parts of Phellodendron amurense, 9 parts of Galla chinensis, 10 parts of Angelica dahurica, 8 parts of Dragon's Blood, 6 parts of aloe gel, 10 parts of sodium γ-polyglutamate, 15 parts of ethylhexyl palmitate, and 8 parts of phytosterol composed of β-sitosterol and campesterol in a mass ratio of 1:2;

[0037] The preparation method of the Sanguisorba officinalis extract in this embodiment is as follows: grind the Sanguisorba officinalis, add 4 times the weight of water to boil for 4 hours, filter out the medicinal liquid, add 8 times the weight of water to boil for 6 hours, filter out the medicinal liquid, and discard the medicinal residue; combine the two medicinal liquids and evaporate to dryness to obtain the Sanguisorba officinalis extract;

[0038] The ascorbic acid solution in this embodiment is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:60, adding ascorbic acid to the distilled water and stirring evenly to obtain an ascorbic acid solution;

[0039] The preparation method of the compound composition comprises the following steps:

[0040] Step 1: crush peach gum and add it into distilled water while stirring to obtain a peach gum solution with a mass concentration of 30%; add chitosan into ascorbic acid solution to obtain a chitosan solution; add python oil extract into the peach gum solution and perform high-speed shear treatment at a speed of 8000 r / min and a temperature of 35°C for 8 minutes, then add chitosan solution and perform low-speed shear treatment at a speed of 600 r / min and a temperature of 50°C for 10 minutes to obtain composite raw material A;

[0041] Step 2: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 6 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica, soak them, and then ultrasonically treat them at a power of 700w and a temperature of 60°C for 40min, filter and obtain the liquid medicine, add distilled water to the residue, and ultrasonically treat them at a power of 700w and a temperature of 60°C for 40min, repeat the filtration treatment 2-3 times, combine the filtrate, and concentrate it to a water content of 50% to obtain a mixed solution;

[0042] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterol, and homogenizing under high pressure for 45 minutes at a pressure of 80 MPa, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2, and homogenizing under high pressure for 45 minutes at a pressure of 80 MPa, and then adding menthol, borneol, Sanguisorba officinalis extract, Dragon's Blood, and sodium γ-polyglutamate, and homogenizing under high pressure for 45 minutes at a pressure of 80 MPa, to obtain a composite composition containing python oil.

[0043] Example 3

[0044] The composite composition containing python oil for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 60 parts of python oil extract, 18 parts of peach gum, 20 parts of chitosan, 12 parts of menthol, 15 parts of borneol, 6 parts of Sanguisorba officinalis extract, 14 parts of Phellodendron amurense, 8 parts of Galla chinensis, 8 parts of Angelica dahurica, 7.5 parts of Dragon's Blood, 5 parts of aloe gel, 6 parts of sodium γ-polyglutamate, 10 parts of ethylhexyl palmitate, and 7 parts of phytosterol composed of β-sitosterol, stigmasterol, and campesterol in a mass ratio of 2:1:1;

[0045] The ascorbic acid solution in this embodiment is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:55, adding ascorbic acid to the distilled water and stirring evenly to obtain an ascorbic acid solution;

[0046] The preparation method of the compound composition comprises the following steps:

[0047] Step 1: After crushing peach gum, add it into distilled water while stirring to obtain a peach gum solution with a mass concentration of 25%; add chitosan into ascorbic acid solution to obtain a chitosan solution; add python oil extract into the peach gum solution and perform high-speed shear treatment at a speed of 7000r / min and a temperature of 32°C for 7min, then add chitosan solution and perform low-speed shear treatment at a speed of 500r / min and a temperature of 45°C for 7min to obtain composite raw material A;

[0048] Step 2: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 5 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica, soak them, and then ultrasonically treat them at a power of 600w and a temperature of 45°C for 35min, filter and obtain the liquid medicine, add distilled water to the residue, and ultrasonically treat them at a power of 650w and a temperature of 50°C for 36min, repeat the filtration treatment 3 times, combine the filtrate, and concentrate it to a water content of 42% to obtain a mixed solution;

[0049] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterol, and performing high-pressure homogenization at a pressure of 70 MPa for 30 minutes, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2, and performing high-pressure homogenization at a pressure of 55 MPa for 40 minutes, and then adding menthol, borneol, Sanguisorba officinalis extract, Sanguisorba officinalis, and sodium γ-polyglutamate, and performing high-pressure homogenization at a pressure of 65 MPa for 23 minutes, to obtain a composite composition containing python oil.

[0050] Example 4

[0051] The composite composition containing python oil for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 55 parts of python oil extract, 23 parts of peach gum, 19 parts of chitosan, 13 parts of menthol, 16 parts of borneol, 5 parts of Sanguisorba officinalis extract, 12 parts of Phellodendron amurense, 6 parts of Galla chinensis, 9 parts of Angelica dahurica, 7 parts of Dragon's Blood, 4 parts of aloe vera gel, 8 parts of sodium γ-polyglutamate, 12 parts of ethylhexyl palmitate, and 6 parts of β-sitosterol;

[0052] The ascorbic acid solution in this embodiment is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:52, adding ascorbic acid to the distilled water and stirring evenly to obtain an ascorbic acid solution;

[0053] The preparation method of the compound composition comprises the following steps:

[0054] Step 1: crush peach gum and add it into distilled water while stirring to obtain a peach gum solution with a mass concentration of 28%; add chitosan into ascorbic acid solution to obtain a chitosan solution; add python oil extract into the peach gum solution and perform high-speed shear treatment at a speed of 6000r / min and a temperature of 35°C for 6min, then add chitosan solution and perform low-speed shear treatment at a speed of 450r / min and a temperature of 48°C for 9min to obtain composite raw material A;

[0055] Step 2: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 6 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica to soak, and then ultrasonically treat for 30 minutes at a power of 650w and a temperature of 50°C, filter to obtain the liquid medicine, add distilled water to the residue and ultrasonically treat for 35 minutes at a power of 550w and a temperature of 42°C, repeat the filtration treatment twice, combine the filtrate, and concentrate to a water content of 45% to obtain a mixed solution;

[0056] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterol, and performing high-pressure homogenization at a pressure of 60 MPa for 40 minutes, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2, and performing high-pressure homogenization at a pressure of 75 MPa for 25 minutes, and then adding menthol, borneol, Sanguisorba officinalis extract, Dragon's Blood, and sodium γ-polyglutamate, and performing high-pressure homogenization at a pressure of 70 MPa for 35 minutes, to obtain a composite composition containing python oil.

[0057] Comparative Example 1

[0058] In this application, tea oil is replaced with python oil extract, and the rest is the same as Example 4.

[0059] The tea oil compound composition for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 55 parts of python oil extract, 23 parts of peach gum, 19 parts of chitosan, 13 parts of menthol, 16 parts of borneol, 5 parts of sanguisorba officinalis extract, 12 parts of phellodendron, 6 parts of gallnut, 9 parts of angelica dahurica, 7 parts of dragon's blood, 4 parts of aloe gel, 8 parts of sodium γ-polyglutamate, 12 parts of ethylhexyl palmitate, and 6 parts of β-sitosterol;

[0060] The ascorbic acid solution in this comparative example is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:52, adding ascorbic acid to the distilled water and stirring evenly to obtain an ascorbic acid solution;

[0061] The preparation method of the compound composition comprises the following steps:

[0062] Step 1: crush peach gum and add it into distilled water while stirring to obtain a peach gum solution with a mass concentration of 28%; add chitosan into ascorbic acid solution to obtain a chitosan solution; add tea oil into the peach gum solution and perform high-speed shear treatment at a speed of 6000 r / min and a temperature of 35°C for 6 minutes, then add the chitosan solution and perform low-speed shear treatment at a speed of 450 r / min and a temperature of 48°C for 9 minutes to obtain composite raw material A;

[0063] Step 2: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 6 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica to soak, and then ultrasonically treat for 30 minutes at a power of 650w and a temperature of 50°C, filter to obtain the liquid medicine, add distilled water to the residue and ultrasonically treat for 35 minutes at a power of 550w and a temperature of 42°C, repeat the filtration treatment twice, combine the filtrate, and concentrate to a water content of 45% to obtain a mixed solution;

[0064] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterol, and performing high-pressure homogenization at a pressure of 60 MPa for 40 minutes, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2, and performing high-pressure homogenization at a pressure of 75 MPa for 25 minutes, and then adding menthol, borneol, Sanguisorba officinalis extract, Dragon's Blood, and sodium γ-polyglutamate, and performing high-pressure homogenization at a pressure of 70 MPa for 35 minutes, to obtain a composite composition containing python oil.

[0065] Comparative Example 2

[0066] This application does not contain aloe vera gel, phytosterols and sodium γ-polyglutamate, and the rest is the same as Example 4.

[0067] The composite composition containing python oil for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 55 parts of python oil extract, 23 parts of peach gum, 19 parts of chitosan, 13 parts of menthol, 16 parts of borneol, 5 parts of Sanguisorba officinalis extract, 12 parts of Phellodendron amurense, 6 parts of Galla chinensis, 9 parts of Angelica dahurica, 7 parts of Dragon's Blood, and 12 parts of ethylhexyl palmitate;

[0068] The ascorbic acid solution of this comparative example is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:52, adding ascorbic acid into the distilled water and stirring evenly to obtain an ascorbic acid solution;

[0069] The preparation method of the compound composition comprises the following steps:

[0070] Step 1: crush peach gum and add it into distilled water while stirring to obtain a peach gum solution with a mass concentration of 28%; add chitosan into ascorbic acid solution to obtain a chitosan solution; add python oil extract into the peach gum solution and perform high-speed shear treatment at a speed of 6000r / min and a temperature of 35°C for 6min, then add chitosan solution and perform low-speed shear treatment at a speed of 450r / min and a temperature of 48°C for 9min to obtain composite raw material A;

[0071] Step 2: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 6 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica to soak, and then ultrasonically treat for 30 minutes at a power of 650w and a temperature of 50°C, filter to obtain the liquid medicine, add distilled water to the residue and ultrasonically treat for 35 minutes at a power of 550w and a temperature of 42°C, repeat the filtration treatment twice, combine the filtrate, and concentrate to a water content of 45% to obtain a mixed solution;

[0072] Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate and homogenizing under high pressure for 40 minutes at a pressure of 60 MPa, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2 and homogenizing under high pressure for 25 minutes at a pressure of 75 MPa, and then adding menthol, borneol, Sanguisorba officinalis extract and Sanguisorba officinalis and homogenizing under high pressure for 35 minutes at a pressure of 70 MPa to obtain a composite composition containing python oil.

[0073] Comparative Example 3

[0074] This application does not contain peach gum and chitosan, and the other raw materials are the same as those in Example 4.

[0075] The composite composition containing python oil for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 55 parts of python oil extract, 13 parts of menthol, 16 parts of borneol, 5 parts of Sanguisorba officinalis extract, 12 parts of Phellodendron amurense, 6 parts of Galla chinensis, 9 parts of Angelica dahurica, 7 parts of Dragon's Blood, 4 parts of aloe gel, 8 parts of sodium γ-polyglutamate, 12 parts of ethylhexyl palmitate, and 6 parts of β-sitosterol;

[0076] The preparation method of the compound composition comprises the following steps:

[0077] Step 1: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 6 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica to soak, and then ultrasonically treat for 30 minutes at a power of 650w and a temperature of 50℃, filter to obtain the liquid medicine, add distilled water to the residue and ultrasonically treat for 35 minutes at a power of 550w and a temperature of 42℃, repeat the filtration treatment twice, combine the filtrate, and concentrate to a water content of 45% to obtain a mixed solution;

[0078] Step 2: placing the python oil extract in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterol, and performing high-pressure homogenization at a pressure of 60 MPa for 40 minutes, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 1, and performing high-pressure homogenization at a pressure of 75 MPa for 25 minutes, and then adding menthol, borneol, Sanguisorba officinalis extract, Dragon's Blood, and sodium γ-polyglutamate, and performing high-pressure homogenization at a pressure of 70 MPa for 35 minutes, to obtain a composite composition containing python oil.

[0079] Comparative Example 4

[0080] The preparation method of this application is different from that of Example 4.

[0081] The composite composition containing python oil for treating hemorrhoids of this embodiment comprises the following raw materials in parts by weight: 55 parts of python oil extract, 23 parts of peach gum, 19 parts of chitosan, 13 parts of menthol, 16 parts of borneol, 5 parts of Sanguisorba officinalis extract, 12 parts of Phellodendron amurense, 6 parts of Galla chinensis, 9 parts of Angelica dahurica, 7 parts of Dragon's Blood, 4 parts of aloe vera gel, 8 parts of sodium γ-polyglutamate, 12 parts of ethylhexyl palmitate, and 6 parts of β-sitosterol;

[0082] The preparation method of the compound composition comprises the following steps:

[0083] Step 1: After grinding and crushing Phellodendron amurense, Gallnut chinensis and Angelica dahurica, add distilled water 6 times the total amount of Phellodendron amurense, Gallnut chinensis and Angelica dahurica, stir and mix, decoct for 40 minutes and filter, repeat the decoction operation for 3 times on the residue and combine all the filtrates, concentrate to a water content of 45% to obtain a mixed solution;

[0084] Step 2: Add python oil extract, peach gum, chitosan, menthol, borneol, sanguisorba officinalis extract, phellodendron, gallnut, angelica dahurica, dragon's blood, aloe gel, sodium γ-polyglutamate, ethylhexyl palmitate, and β-sitosterol into the mixed solution prepared in step 1, and stir and mix evenly to obtain the composite composition containing python oil of this comparative example.

[0085] The present embodiments 1 to 4 and comparative examples 1 to 4 were used to conduct a treatment experiment on hemorrhoids in mice. The specific process is as follows:

[0086] Experimental animals Kunming mice: 80 Kunming mice, half male and half female, weighing 23-25 ​​g. SD rats: 120 Kunming mice, half male and half female, weighing 170-230 g. Anti-inflammatory and swelling experiments 80 Kunming mice, half male and half female, were randomly divided into 10 groups, 8 mice in each group. The mice in group 1 were used as the control group; the mice in group 2 were used as the Mayinglong Musk Hemorrhoid Cream group, the mice in groups 3 to 6 corresponded to the groups of the composite composition containing python oil prepared by Examples 1 to 4 of the present invention, and the mice in groups 7 to 10 corresponded to the groups of the composite composition containing python oil prepared by Comparative Examples 1 to 4.

[0087] When conducting the anti-inflammatory and swelling experiment, the two ears of the mice in the control group of group 1 were smeared with vaseline, the two ears of the mice in group 2 were smeared with Mayinglong Musk Hemorrhoid Cream, and the two ears of the mice in groups 3 to 10 were smeared with the corresponding compound composition containing python oil. The dosage of each group of mice was the same. After 1 hour of smearing, the medicine on the two ears of the mice was wiped off, and 0.05 ml of xylene was smeared on the left ear of the mice. After 30 minutes, the same amount of medicine was applied again. After another 1 hour, the mice were killed by dislocating the neck, and the two ears of the mice were immediately cut off. A rubber plug puncher was used to punch out 8 mm equal-area ear pieces at the same part of the two ears, and the weight was weighed using an analytical balance. The swelling degree and swelling inhibition rate were calculated, and the results were averaged. The calculation formula is as follows:

[0088]

[0089]

[0090] Hemorrhoid ulcer surface healing experiment 120 SD rats, half male and half female, were taken, first the perianal skin was disinfected, 0.05 ml of glacial acetic acid was injected outside the anus of the rat to cause ulcers in the rat, the perianal area of ​​the rat was swollen and there was inflammatory exudation and visible white ulcer surface. The rats were randomly divided into 10 groups, 12 in each group. The mice in group 1 were used as the control group; the mice in group 2 were used as the Mayinglong Musk Hemorrhoid Cream group, the mice in groups 3 to 6 corresponded to the groups of the composite composition containing python oil prepared by Examples 1 to 4 of the present invention, and the mice in groups 7 to 10 corresponded to the groups of the composite composition containing python oil prepared by Comparative Examples 1 to 4. The control group was smeared with vaseline, and the 2nd to 10th groups were smeared with the corresponding dose of drugs, 3 times a day, and the inflammatory exudation, redness and swelling of the ulcer surface and the time of scab shedding of the ulcer surface wound were observed to evaluate the degree of healing of the ulcer. The scoring criteria were: 1 point for ulcer exudate, 2 points for a small amount of ulcer exudate, 3 points for scabs that did not fall off and basically healed, and 4 points for scabs that fell off and completely healed. After the hemorrhoidal wounds were completely healed, the rats were kept in a normal environment and conditions for 3 months, and then the number of perianal recurrences of rats in each group was counted. Perianal swelling, flushing or bleeding was considered as hemorrhoid recurrence. Each experimental group was statistically calculated and the results were averaged.

[0091] Table 1 Hemorrhoids experimental results

[0092]

[0093] The above results show that, compared with the blank group, the compound composition of Mayinglong Musk Hemorrhoid Cream Group, Examples 1 to 4 and Comparative Examples 1 to 4 has a certain inhibitory effect on the swelling of mice, and in terms of promoting the healing of hemorrhoid wounds, Examples 1 to 4 are all better than Comparative Examples 1 to 4. The python oil extract in the present invention can synergize with peach gum, chitosan, sanguisorba officinalis extract, phellodendron, gallnut, angelica dahurica, dragon's blood, aloe gel, etc., and can play a role in rapid anti-inflammatory, antipruritic, analgesic and hemostatic effects, relieve the symptoms of hemorrhoids such as swelling, pain, and bleeding, effectively promote the healing of hemorrhoid wounds, and have a good therapeutic effect.

[0094] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A composite composition containing python oil for treating hemorrhoids, characterized in that: The invention is prepared from the following raw materials in parts by weight: 50-70 parts of python oil extract, 15-25 parts of peach gum, 15-25 parts of chitosan, 11-14 parts of menthol, 13-18 parts of borneol, 4-8 parts of Sanguisorba officinalis extract, 11-15 parts of Phellodendron amurense, 5-9 parts of Galla chinensis, 7-10 parts of Angelica dahurica, 7-8 parts of Dragon's Blood, 3-6 parts of aloe vera gel, 5-10 parts of sodium γ-polyglutamate, 8-15 parts of ethylhexyl palmitate, and 4-8 parts of phytosterols; the phytosterols are one or a combination of two or more of β-sitosterol, stigmasterol, campesterol and rapeseed sterol; The preparation method of the python oil extract comprises the following steps: removing fat from the abdomen of a python, removing impurities and a thin film on the surface of the fat, placing the fat in an oil refining pot, refining the fat at a temperature of 85 to 105° C., filtering and removing impurities, and cooling the fat to obtain the python oil extract; The preparation method of the Sanguisorba officinalis extract comprises the following steps: crushing the Sanguisorba officinalis, adding 3 to 4 times the weight of water to boil for 3 to 4 hours, filtering out the medicinal liquid, adding 6 to 8 times the weight of water to the medicinal residue and boiling for 5 to 6 hours, filtering out the medicinal liquid, and discarding the medicinal residue; combining the two medicinal liquids and evaporating to dryness to obtain the Sanguisorba officinalis extract; The preparation method of the composite composition containing python oil for treating hemorrhoids comprises the following steps: Step 1: crush the peach gum and add it into distilled water while stirring to obtain a peach gum solution; Chitosan is added to an ascorbic acid solution to obtain a chitosan solution; python oil extract is added to a peach gum solution and subjected to high-speed shear treatment, and then the chitosan solution is added to the solution and subjected to low-speed shear treatment to obtain a composite raw material A; the ascorbic acid solution is prepared by weighing ascorbic acid and distilled water at a weight ratio of 1:50-60, adding ascorbic acid to the distilled water and stirring uniformly to obtain an ascorbic acid solution; Step 2: grind and crush Phellodendron amurense, Galla chinensis, and Angelica dahurica, soak them in distilled water, and then perform ultrasonic treatment, filter and obtain the medicinal solution, add distilled water to the medicinal residues for ultrasonic treatment, repeat 2 to 3 times, combine the filtrate, and concentrate to a water content of 40 to 50% to obtain a mixed solution; Step 3: placing the composite raw material A prepared in the above step 1 in a reaction kettle, adding ethylhexyl palmitate, aloe gel, and phytosterols for high-pressure homogenization, then adding the Sanguisorba officinalis extract and the mixed solution prepared in the above step 2 for high-pressure homogenization again, and then adding menthol, borneol, Sanguisorba officinalis extract, Dragon's Blood, and sodium γ-polyglutamate for high-pressure homogenization to obtain a composite composition containing python oil.

2. A composite composition containing python oil for treating hemorrhoids according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 55 parts of python oil extract, 23 parts of peach gum, 19 parts of chitosan, 13 parts of menthol, 16 parts of borneol, 5 parts of sanguisorba officinalis extract, 12 parts of phellodendron amurense, 6 parts of gallnut, 9 parts of angelica dahurica, 7 parts of dragon's blood, 4 parts of aloe vera gel, 8 parts of sodium polyglutamate gamma-glutamate, 12 parts of ethylhexyl palmitate and 6 parts of phytosterol.

3. A composite composition containing python oil for treating hemorrhoids according to claim 1, characterized in that: In step 1, the mass concentration of peach gum in the peach gum solution is 20-30%; in step 2, the distilled water is 4-6 times the total amount of Phellodendron amurense, Galla chinensis and Angelica dahurica.

4. A composite composition containing python oil for treating hemorrhoids according to claim 1, characterized in that: In step 1, the rotation speed of the high-speed shearing is 5000-8000 r / min, the temperature is 30-35° C., and the time is 4-8 min; the rotation speed of the low-speed shearing is 400-600 r / min, the temperature is 40-50° C., and the time is 6-10 min.

5. A composite composition containing python oil for treating hemorrhoids according to claim 1, characterized in that: In step 2, the ultrasonic treatment power is 500-700w, the temperature is 40-60°C, and the time is 30-40min.

6. A composite composition containing python oil for treating hemorrhoids according to claim 1, characterized in that: In step 3, the pressure of the high-pressure homogenization is 50-80 MPa, and the pressure holding time is 20-45 min.

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