A cryogenic plasma device for visual treatment of intestinal tumors

By designing a low-temperature plasma device including an air channel and a discharge layer, combined with the combination of air pump and valve components, the problem of difficulty in operating in treating intestinal tumors is solved, and precise treatment of intestinal tumors and efficient tumor tissue attraction is achieved.

CN116688361BActive Publication Date: 2025-06-20UNIV OF SCI & TECH OF CHINA
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Patent Information

Application Number
CN202310519008.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-05-10
Publication Date
2025-06-20
Estimated Expiration
2043-05-10

AI Technical Summary

Technical Problem

When using low-temperature plasma to treat tumor cells in the intestine, it is difficult to accurately penetrate the low-temperature plasma into the intestine and act on the lesion tissue, which is difficult to operate.

Method used

A low-temperature plasma device including an outer hose and an inner hose is designed. An air conduction channel is formed between the outer hose and the inner hose. The outer surface and inner surface of the air conduction channel are provided with a discharge layer, and the surface of the discharge layer is coated with an insulating layer. Through the cooperation of light probes, temperature sensors and lighting lamps, visual treatment of tumor lesions in the intestines is achieved, and through the cooperation of air pumps and valve components, the delivery of low-temperature plasma and the attraction of tumor tissue clumps are achieved.

Benefits of technology

It realizes precise treatment of intestinal tumors, simplifies the operation process, and improves the efficiency and safety of treatment.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention relates to the field of low-temperature plasma treatment equipment, and particularly to a low-temperature plasma device for visually treating intestinal tumors, which includes an outer hose and an inner hose passing through the inside of the outer hose. It is characterized in that a gas conduction channel is formed between the outer hose and the inner hose, and discharge layers are provided on both the outer surface and the inner surface of the gas conduction channel. An insulating layer is coated on the surface of the discharge layer. A flexible wire tube is provided outside the outer hose, and an end shell is connected to the end of the flexible wire tube. The gas conduction channel penetrates the end face of the end shell, and a light probe, a temperature sensor, and a lighting lamp are provided on the end face of the end shell. In the present invention, a gas conduction channel is provided in the flexible wire tube, and a discharge layer is provided in the gas conduction channel, so that low-temperature plasma can be generated in the discharge layer, and the low-temperature plasma in the gas conduction channel is conducted by means of ventilation. The low-temperature plasma is transported to the tumor lesion site in the intestine in a visual manner through the light probe and the lighting lamp, and the purpose of accurately treating intestinal tumors is conveniently achieved.
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Description

Technical Field

[0001] The present invention relates to the field of cryogenic plasma treatment equipment, and particularly to a cryogenic plasma device for visual treatment of intestinal tumors. Background Art

[0002] Colorectal cancer is a type of cancer in the digestive tract, with a relatively high incidence and mortality rate, posing a serious threat to human health. Surgery, radiotherapy, chemotherapy, molecular targeted therapy, and immunotherapy are common methods for treating colon cancer. However, the recovery rate of colorectal cancer is quite low;

[0003] Plasma is the fourth state of matter after solid, liquid, and gas. When the applied voltage reaches the breakdown voltage, gas molecules are ionized to produce a mixture including electrons, ions, atoms, and atomic clusters. Cryogenic plasma can be generated at near-room-temperature atmospheric pressure, thus forming a mild plasma-tumor interface, which is lethal to tumor cells without causing too much damage to surrounding tissues. Cryogenic plasma can effectively inhibit or kill tumor cells such as intestinal cancer, lung cancer, cervical cancer, nasopharyngeal cancer, and skin cancer. Atmospheric pressure cryogenic plasma has the advantages of selectively killing tumor cells and being applicable to a wide variety of tumor types, and is a new method for cancer treatment.

[0004] The difficulty in using cryogenic plasma to treat tumor cells in the intestinal tract lies in precisely introducing the cryogenic plasma deep into the intestine to act on the diseased tissue site, which is quite difficult to operate. Summary of the Invention

[0005] The object of the present invention is to solve the following problems existing in the prior art: The difficulty in using cryogenic plasma to treat tumor cells in the intestinal tract lies in precisely introducing the cryogenic plasma deep into the intestine to act on the diseased tissue site, which is quite difficult to operate.

[0006] To solve the problems existing in the prior art, the present invention provides a cryogenic plasma device for visual treatment of intestinal tumors, including an outer hose and an inner hose penetrating through the inside of the outer hose. It is characterized in that a gas conduction channel is formed between the outer hose and the inner hose, and discharge layers are provided on both the outer surface and the inner surface of the gas conduction channel. An insulating layer is coated on the surface of the discharge layer. A flexible wire tube is provided outside the outer hose, and an end shell is connected to the end of the flexible wire tube. The gas conduction channel penetrates the end face of the end shell, and a light probe, a temperature sensor, and a lighting lamp are provided on the end face of the end shell. An air pump is provided at the end of the flexible wire tube away from the end shell, and the air pump is used to conduct gas into the gas conduction channel.

[0007] Preferably, the discharge layer is made of copper material, and the insulating layer is made of polyester film.

[0008] Preferably, an air return channel is formed through the inside of the inner hose, and the air return channel penetrates the end face of the end housing. The air guide channel and the air return channel are selectively connected to the exhaust and suction ends of the air pump through a valve assembly.

[0009] Preferably, the valve assembly includes a valve housing. A valve body rotates inside the valve housing. An anterior arc housing and a posterior arc housing that are slidably fitted to the edge of the valve body are fixed inside the valve housing. A sealed first valve chamber and a second valve chamber are formed between the anterior arc housing and the valve body. A sealed third valve chamber is formed between the posterior arc housing and the valve body. A valve hole penetrates radially through the surface of the valve body. The air return channel communicates with the first valve chamber. The second valve chamber penetrates through the outer space of the valve housing through a through pipe. The suction end of the air pump communicates with the third valve chamber. The exhaust end of the air pump and the air guide channel both communicate with the gap between the valve housing and the valve body. Two fixed valve plates are symmetrically fixed on the inner wall of the valve housing between the connection position of the air guide channel and the connection position of the exhaust end of the air pump. Two moving valve plates that are aligned with the fixed valve plates are fixed to the edge of the valve body. When the valve hole communicates the first valve chamber and the third valve chamber, the moving valve plate is in airtight contact with the fixed valve plate. When the valve hole communicates the second valve chamber and the third valve chamber, there is a gap between the moving valve plate and the fixed valve plate.

[0010] Preferably, a rotating handle is concentrically fixed to the valve body. The rotating handle extends radially along the valve body so that the rotating handle can rotate following the valve body. Two limiting columns are fixed on the surface of the valve housing for limiting the rotation angle of the rotating handle from the first valve chamber to the second valve chamber. A positioning body is fixed on the surface of the valve housing. A spring is connected between the positioning body and the extending end of the rotating handle. When the rotating handle is located at the middle position between the two limiting columns, the spring is in the maximum stretched state.

[0011] Preferably, a filter screen is encapsulated at the end of the through pipe.

[0012] Preferably, a collector is arranged between the suction end of the air pump and the third valve chamber. The collector includes a collection box. A filter plate is arranged inside the collection box. The filter plate divides the inner space of the collection box into upper and lower parts. The suction end of the air pump communicates with the top of the collection box. The third valve chamber communicates with the bottom of the collection box.

[0013] Compared with the related art, the low-temperature plasma device for visual treatment of intestinal tumors provided by the present invention has the following beneficial effects:

[0014] 1. The present invention provides an air guide channel inside the flexible wire tube and arranges a discharge layer in the air guide channel so that low-temperature plasma can be generated inside the discharge layer. The low-temperature plasma in the air guide channel is conducted by means of ventilation. The low-temperature plasma is transported to the tumor lesion site in the intestine in a visual manner through a light probe and a lighting lamp, conveniently achieving the purpose of precise treatment of intestinal tumors.

[0015] 2. The present invention provides an air return channel inside the inner hose. By means of an air pump, negative pressure is generated in the air return channel, and the tumor tissue mass after being treated with plasma in the intestine can be timely attracted out of the body.

[0016] 3. The present invention uses a valve assembly to switch the air guide channel for air guiding and the air return channel for air suction to work alternately, and only one air pump is used to achieve the purpose of low-temperature plasma delivery and tumor tissue mass aspiration. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 is a schematic diagram of the structures of the air guide channel and the air return channel of the present invention;

[0019] Figure 3 is a schematic diagram of the end face structure of the end shell of the present invention;

[0020] Figure 4 is a schematic diagram of the connection structure among the valve assembly, the collector, and the air pump of the present invention;

[0021] Figure 5 is a schematic diagram of the structure of the collector of the present invention;

[0022] Figure 6 is one of the schematic diagrams of the structure of the valve assembly of the present invention;

[0023] Figure 7 is the second schematic diagram of the structure of the valve assembly of the present invention;

[0024] Figure 8 is a schematic diagram of the valve body torsion limit structure of the present invention.

[0025] Reference numerals in the figures: 1, tube shell; 2, flexible wire tube; 3, end shell; 31, light probe; 32, temperature sensor; 33, lighting lamp; 4, valve assembly; 41, valve shell; 42, valve body; 43, moving valve plate; 44, fixed valve plate; 45, valve hole; 46, front arc shell; 47, first valve cavity; 48, second valve cavity; 49, rear arc shell; 410, third valve cavity; 411, through pipe; 412, turning handle; 413, positioning body; 414, limit post; 5, air pump; 6, collector; 61, collection box; 62, filter plate; 7, outer hose; 71, air guide channel; 8, inner hose; 81, air return channel; 9, discharge layer. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0026] In order to make the objectives, technical solutions, and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0027] The following describes the specific implementation of the present invention in detail with reference to specific embodiments.

[0028] Embodiment 1

[0029] As Figure 1-3 shown, a cryogenic plasma device for visual treatment of intestinal tumors has a tube shell 1. An outer hose 7 passes through the tube shell 1, and an inner hose 8 passes through the inside of the outer hose 7. An air guide channel 71 is formed between the outer hose 7 and the inner hose 8. A flexible wire tube 2 is fixed to the end face of the tube shell 1. The flexible wire tube 2 covers the outer layer of the outer hose 7. An end shell 3 is fixed to the end of the flexible wire tube 2 away from the tube shell 1. The outer hose 7 and the inner hose 8 are embedded in the end shell 3, so that the air guide channel 71 penetrates the end face of the end shell 3. The exhaust end of an air pump 5 is connected to the air guide channel 71;

[0030] A light probe 31, a temperature sensor 32 and a lighting lamp 33 are embedded and fixed on the end face of the end shell 3. The lines of the light probe 31, the temperature sensor 32 and the lighting lamp 33 extend from inside the flexible wire tube 2 to inside the tube shell 1. The optical fiber line and the power supply line are connected to the light probe 31, the temperature sensor 32 and the lighting lamp 33 from the part of the tube shell 1. The light probe 31 is connected to a visualization screen;

[0031] As Figure 2-3 shown, a discharge layer 9 is pasted on the outer surface of the inner hose 8 and the inner surface of the outer hose 7. That is, the discharge layer 9 is distributed on the outer surface and the inner surface of the air guide channel 71. An insulating layer is coated on the surface of the discharge layer 9. The power supply line is connected to the discharge layer 9 from the part of the tube shell 1;

[0032] The outer hose 7 and the inner hose 8 are made of polyurethane plastic. The flexible wire tube 2 is made of silica gel material. The discharge layer 9 is made of copper material. The insulating layer is made of polyester film;

[0033] The end shell 3 is inserted into the intestine. The lighting lamp 33 assists the light probe 31 to take pictures of the inside of the intestine. The tumor lesion site is accurately identified through an external visualization screen. The power supply supplies power to the discharge layer 9, and cryogenic plasma is generated between the discharge layers 9. The air pump 5 is turned on to supply air to the air guide channel 71. The gas transports the cryogenic plasma in the air guide channel 71 to one end of the end shell 3, so that the cryogenic plasma acts on the tumor lesion site to achieve the treatment purpose. The temperature sensor 32 monitors the temperature of the plasma action site during the treatment process, so as to stop the treatment in time when the temperature is abnormal.

[0034] Embodiment 2

[0035] As Figure 2-4, as shown in FIGS. 6 - 8, an air return passage 81 is formed through the interior of the inner hose 8, and the through - end of the air return passage 81 penetrates the end face of the end shell 3. The valve assembly 4 includes a circular valve housing 41. A circular valve body 42 is rotatably installed at the central position within the valve housing 41. The front arc shell 46 and the rear arc shell 49 are fixedly installed inside the valve housing 41. The front arc shell 46 and the rear arc shell 49 slidably fit the edge of the valve body 42. A sealed first valve chamber 47 and a second valve chamber 48 are formed between the front arc shell 46 and the valve body 42, and a sealed third valve chamber 410 is formed between the rear arc shell 49 and the valve body 42. The valve body 42 has a valve hole 45 radially penetrating its surface. The air return passage 81 communicates with the first valve chamber 47. The second valve chamber 48 penetrates the external space of the valve housing 41 through a through - pipe 411. The suction end of the air pump 5 communicates with the third valve chamber 410, and the exhaust end of the air pump 5 and the air guide passage 71 both communicate with the gap between the valve housing 41 and the valve body 42. Two fixed valve plates 44 are symmetrically fixed on the inner wall of the valve housing 41 between the connection position of the air guide passage 71 and the connection position of the exhaust end of the air pump 5. A movable valve plate 43 for aligning with the two fixed valve plates 44 is fixed to the edge of the valve body 42;

[0036] A rotating handle 412 is concentrically fixed to the lower part of the valve body 42 and passing through the valve housing 41. The rotating handle 412 extends radially along the valve body 42, so that the rotating handle 412 can rotate following the valve body 42. Two limit posts 414 are fixed on the surface of the valve housing 41 to limit the rotation angle of the rotating handle 412 from the first valve chamber 47 to the second valve chamber 48. A positioning body 413 is fixed on the surface of the valve housing 41. A spring is connected between the positioning body 413 and the extended end of the rotating handle 412. When the rotating handle 412 is located at the middle position between the two limit posts 414, the spring is in the maximum stretched state;

[0037] As Figure 7 shown, when supplying gas for treating the interior of the intestine, the valve hole 45 communicates with the second valve chamber 48 and the third valve chamber 410. The movable valve plate 43 separates from the fixed valve plate 44 to form a gap. The gas discharged from the exhaust end of the air pump 5 enters the gap between the valve housing 41 and the valve body 42, and passes through the gap between the movable valve plate 43 and the fixed valve plate 44 to enter the air guide passage 71. The suction end of the air pump 5 inhales external air through the third valve chamber 410, the valve hole 45, the second valve chamber 48, and the through - pipe 411 to achieve air pressure balance. A filter screen is encapsulated at the end of the through - pipe 411 to filter impurities in the air;

[0038] As Figure 6As shown, the tumor tissue after plasma treatment will undergo gasification, liquefaction, and solidification and shedding. It is necessary to suck out the tumor tissue mass after plasma treatment out of the body. First, cut off the power supply to the discharge layer 9, and then rotate the valve body 42 through the handle. The rotating handle 412 rotates accordingly. Under the pulling force of the spring and the limitation of the limiting column 414, the valve hole 45 rotates and is positioned to align with the first valve cavity 47. At this time, the third valve cavity 410, the valve hole 45, the first valve cavity 47, and the air return channel 81 are connected. The moving valve plate 43 and the fixed valve plate 44 are sealed and fitted to cut off the passage between the air guide channel 71 and the air pump 5. The air pump 5 sucks air to form a negative pressure in the third valve cavity 410, the valve hole 45, the first valve cavity 47, and the air return channel 81, and sucks out the tumor tissue mass out of the body through the negative pressure.

[0039] When treatment needs to be carried out again, reverse the position of the valve body 42 to the original position.

[0040] Embodiment III

[0041] As Figure 4-5 shown, to prevent the sucked tumor tissue mass from entering the air pump 5, a collector 6 is provided between the suction end of the air pump 5 and the third valve cavity 410. The collector 6 includes a collection box 61. A filter plate 62 is provided in the collection box 61. The filter plate 62 divides the internal space of the collection box 61 into upper and lower parts. The suction end of the air pump 5 is communicated with the top of the collection box 61, and the third valve cavity 410 is communicated with the bottom of the collection box 61;

[0042] The sucked tumor tissue mass sequentially passes through the air return channel 81, the first valve cavity 47, the valve hole 45, and the third valve cavity 410 and enters the bottom of the collection box 61. The gas is discharged upward from the collection box 61 through the height difference and the filtration of the filter plate 62, and the tumor tissue mass stays at the bottom of the collection box 61, which is convenient for later centralized treatment.

Claims

1. A cryogenic plasma device for visual treatment of intestinal tumors, comprising an outer hose (7) and an inner hose (8) passing through the inside of the outer hose (7), characterized in that, An air guiding channel (71) is formed between the outer hose (7) and the inner hose (8). Discharge layers (9) are provided on both the outer surface and the inner surface of the air guiding channel (71). An insulating layer is coated on the surface of the discharge layer (9). A flexible wire tube (2) is provided outside the outer hose (7). One end of the flexible wire tube (2) is connected to an end shell (3). The air guiding channel (71) penetrates through the end face of the end shell (3). A light probe (31), a temperature sensor (32) and a lighting lamp (33) are provided on the end face of the end shell (3). An air pump (5) is provided at one end of the flexible wire tube (2) away from the end shell (3). The air pump (5) is used to conduct gas into the air guiding channel (71). An air return channel (81) is formed through the inside of the inner hose (8). The air return channel (81) penetrates through the end face of the end shell (3). The air guiding channel (71) and the air return channel (81) are selectively connected to the exhaust and suction ends of the air pump (5) through a valve assembly (4). The valve assembly (4) includes a valve housing (41). A valve body (42) rotates inside the valve housing (41). A front arc shell (46) and a rear arc shell (49) that are slidably fitted to the edge of the valve body (42) are fixed inside the valve housing (41). A sealed first valve cavity (47) and a second valve cavity (48) are formed between the front arc shell (46) and the valve body (42). A sealed third valve cavity (410) is formed between the rear arc shell (49) and the valve body (42). A valve hole (45) is radially penetrated through the surface of the valve body (42). The air return channel (81) is connected to the first valve cavity (47). The second valve cavity (48) penetrates through the external space of the valve housing (41) through a through pipe (411). The suction end of the air pump (5) is connected to the third valve cavity (410). The exhaust end of the air pump (5) and the air guiding channel (71) are both connected to the gap between the valve housing (41) and the valve body (42). Two fixed valve plates (44) are symmetrically fixed on the inner wall of the valve housing (41) between the connection position of the air guiding channel (71) and the connection position of the exhaust end of the air pump (5). A moving valve plate (43) for aligning with the two fixed valve plates (44) is fixed to the edge of the valve body (42). When the valve hole (45) connects the first valve cavity (47) and the third valve cavity (410), the moving valve plate (43) is in airtight contact with the fixed valve plate (44). When the valve hole (45) connects the second valve cavity (48) and the third valve cavity (410), there is a gap between the moving valve plate (43) and the fixed valve plate (44).

2. The cryogenic plasma device for visual treatment of intestinal tumors according to claim 1, characterized in that, The discharge layer (9) is made of copper material, and the insulating layer is made of polyester film.

3. The cryogenic plasma device for visual treatment of intestinal tumors according to claim 1, characterized in that, A rotating handle (412) is concentrically fixed to the valve body (42). The rotating handle (412) extends radially along the valve body (42) so that the rotating handle (412) can rotate following the valve body (42). Two limit posts (414) are fixed on the surface of the valve housing (41) for restricting the rotation angle of the rotating handle (412) from the first valve chamber (47) to the second valve chamber (48). A positioning body (413) is fixed on the surface of the valve housing (41). A spring is connected between the positioning body (413) and the extending end of the rotating handle (412). When the rotating handle (412) is located at the middle position between the two limit posts (414), the spring is in the maximum stretched state.

4. The cryogenic plasma device for visual treatment of intestinal tumors according to claim 1, characterized in that, A filter screen is encapsulated at the end of the through pipe (411).

5. The cryogenic plasma device for visual treatment of intestinal tumors according to claim 1, characterized in that, A collector (6) is arranged between the suction end of the air pump (5) and the third valve chamber (410). The collector (6) includes a collection box (61). A filter plate (62) is arranged in the collection box (61). The filter plate (62) divides the inner space of the collection box (61) into upper and lower parts. The suction end of the air pump (5) communicates with the top of the collection box (61), and the third valve chamber (410) communicates with the bottom of the collection box (61).

Citation Information

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