A programmable intracranial environment simulation device

Abstract

The present invention discloses a programmable intracranial environment simulation device for simulating the intracranial environment (primarily temperature and pressure). The device comprises a control portion and a cavity portion. The control portion includes a programmable stepper motor controller, a pressure generating module, a stepper motor driver, a DC power supply, a serial port stepper / servo controller, a digital temperature control module, and a digital display temperature controller. The cavity portion comprises a main cavity and a compensatory cavity. The main cavity is connected to the pressure generating module via a pipeline, and the compensatory cavity is connected to the pressure generating module via a pipeline. The present invention allows users to easily obtain the desired intracranial simulated environment. The changing patterns of pressure and temperature are determined by the control program. The present invention can be manually programmed at any time, conveniently and quickly, or more complex programs can be written on an external development platform to obtain a more real-time changing environment.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedicine, and in particular to a programmable intracranial environment simulation device. Background Art

[0002] In modern medical research and education, understanding changes in the intracranial environment is crucial for understanding and treating a range of neurological diseases. Changes in the intracranial environment, including factors such as intracranial pressure and temperature, are crucial for understanding disease mechanisms, diagnosis, treatment, and evaluating treatment outcomes.

[0003] However, monitoring and simulating the intracranial environment faces significant challenges in practice. First, monitoring intracranial pressure and temperature typically requires invasive medical procedures, which can be risky and uncomfortable for patients. Second, intracranial pressure and temperature are affected by a variety of physiological and pathological factors, including heart rate, respiration, changes in body position, brain diseases, and treatments. This makes changes in the intracranial environment extremely complex and difficult to accurately simulate.

[0004] Furthermore, despite numerous studies dedicated to understanding changes in intracranial pressure and temperature and their impact on brain diseases, we lack effective tools to simulate these changes in actual clinical and research practice. Most existing simulation technologies are based on computer models and cannot provide a realistic, dynamic simulation environment. These technologies also cannot easily adjust simulation parameters, such as intracranial pressure and temperature, to simulate different disease states and treatment effects.

[0005] Finally, most existing intracranial environment simulation technologies lack user-friendliness and programmability, making it difficult for physicians and researchers to tailor intracranial environment simulations to their specific needs, such as simulating the effects of specific disease states or treatments on the intracranial environment. Summary of the Invention

[0006] In response to the above technical problems in the related art, the present invention provides a programmable intracranial environment simulation device that can solve the above problems.

[0007] To achieve the above technical objectives, the technical solution of the present invention is implemented as follows:

[0008] A programmable intracranial environment simulation device includes a main cavity, which includes a cavity isolation plate. The upper end of the cavity isolation plate is connected to an acrylic hemispherical cover through a sealing component, and the lower end of the cavity isolation plate is connected to a cavity shell through a screw. A liquid inlet hole is provided in the center of the cavity isolation plate, and the lower liquid port of the liquid inlet hole is connected to a liquid inlet pipe through a liquid inlet channel component. The cavity isolation plate is also evenly provided with a number of micropores connecting the inner cavity of the hemispherical cover and the inner cavity of the cavity shell. A quick plug is provided on one side of the cavity shell, and a semiconductor refrigeration module is provided at the lower end of the inner cavity of the cavity shell. The semiconductor refrigeration module is electrically connected to a digital temperature control module, and the digital temperature control module is controlled by a digital display temperature controller or an external computer. The quick plug is connected to a pressure generating module through a delivery pipe, and the pressure generating module is controlled by a programmable stepper motor controller or an external computer. The pressure generating module is connected to a compensation cavity through a delivery pipe.

[0009] Furthermore, the acrylic hemispherical cover is hemispherical, an annular connecting portion is provided at the open end of the acrylic hemispherical cover, and a detection head is also connected to the acrylic hemispherical cover.

[0010] Furthermore, the lower end of the inner cavity of the cavity shell is connected to an aluminum alloy heat conducting part through screws, and the lower end of the aluminum alloy heat conducting part is connected to the semiconductor refrigeration module.

[0011] Furthermore, a fixed shell is fixedly connected to the outer side of the cavity shell, one end of the liquid inlet pipe is connected to the liquid inlet channel assembly, and the other end passes through the fixed shell and extends out of the cavity; the connection between the cavity shell and the aluminum alloy heat conductor, the connection between the cavity shell and the cavity isolation plate, and the connection between the cavity isolation plate and the annular connection part of the acrylic hemispherical cover are all provided with sealing rings.

[0012] Furthermore, the pressure generating module includes a motor bracket, a motor is installed at one end of the inner cavity of the motor bracket, and a pressure generating cavity is provided at the other end. The power shaft of the motor is connected to the push head through a ball screw transmission, and the end of the pressure generating cavity close to the push head is connected to a silicone film 1 through a sealing pressing sheet, and the other two ends of the pressure generating cavity are respectively provided with a quick plug 2 and a quick plug 3, and the bottom end of the motor bracket is provided with a foot.

[0013] Furthermore, the quick plug one is connected to the quick plug two through a delivery pipe, the quick plug three is connected to the compensation chamber through a delivery pipe, the compensation chamber includes a base, a compensation chamber is provided at the upper end of the base, the upper end opening of the compensation chamber is connected to the silicone film two through a sealing component two, a quick plug four and a quick plug five are provided on the side of the compensation chamber, the quick plug three is connected to the quick plug four through a delivery pipe, and the quick plug five is connected to the liquid inlet interface through a delivery pipe.

[0014] Furthermore, the motor is driven by a stepper motor driver, the stepper motor driver is electrically connected to the programmable stepper motor controller and the serial port stepper / servo controller, and the serial port stepper / servo controller is externally connected to a computer via a cable.

[0015] Furthermore, it also includes an outer shell for installing the control part and the cavity part. The outer shell is also provided with a DC power supply for powering the control part. A number of ventilation holes are evenly provided on the side of the outer shell, and handles are symmetrically provided on the two opposite sides of the outer shell.

[0016] The beneficial effects of the present invention are as follows: the present invention enables users to conveniently obtain the desired intracranial simulation environment, and the changing rules of pressure and temperature are determined by the control program; the present invention can be manually programmed at any time, conveniently and quickly, and more complex programs can also be written on an external development platform to obtain a more real-time changing environment; the two separate chambers and micropore design of the main cavity can be used to inject fluids of different states or different materials to more realistically simulate the physiological state of the brain. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0018] The present invention will be described in further detail below with reference to the accompanying drawings.

[0019] Figure 1 1 is a schematic structural diagram of a programmable intracranial environment simulation device according to an embodiment of the present invention;

[0020] Figure 2 This is a top view of a programmable intracranial environment simulation device according to an embodiment of the present invention with the upper cover of the outer shell opened;

[0021] Figure 3 is a schematic structural diagram of the main cavity according to an embodiment of the present invention;

[0022] Figure 4 is a cross-sectional view of the main cavity according to an embodiment of the present invention;

[0023] Figure 5 is a simplified plan view of the pressure generating module according to an embodiment of the present invention;

[0024] Figure 6 is a schematic structural diagram of the compensatory cavity according to an embodiment of the present invention;

[0025] Figure 7 This is a working principle diagram of a programmable intracranial environment simulation device described in an embodiment of the present invention.

[0026] In the picture:

[0027] 100, main cavity; 1001, acrylic hemispherical cover; 1002, sealing component 1; 1003, cavity isolation plate; 1004, liquid inlet channel assembly; 1005, aluminum alloy heat conductor; 1006, fixed shell; 1007, cavity shell; 1008, quick plug 1; 1009, liquid inlet pipe; 1010, semiconductor refrigeration module; 1101, hemispherical cover cavity; 1102, cavity shell cavity; 10011, detection head; 200, digital temperature control module; 300, pressure generating module; 3001, motor; 3002, screw shaft; 3003, push head; 3004, sealing press; 3005, silicone Film one; 3006, pressure generating chamber; 3007, quick plug two; 3008, quick plug three; 3009, motor bracket; 3010, foot pad; 3011, sleeve; 400, compensation chamber; 4001, compensation chamber; 4002, silicone film two; 4003, sealing component two; 4004, quick plug four; 4005, quick plug five; 501, digital display temperature controller; 502, stepper motor driver; 503, serial port stepper / servo controller; 504, programmable stepper motor controller; 505, DC power supply; 506, liquid inlet interface; 507, handle; 600, outer shell. DETAILED DESCRIPTION

[0028] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention are within the scope of protection of the present invention.

[0029] like Figure 1-7 As shown, a programmable intracranial environment simulation device according to an embodiment of the present invention is used for simulating the intracranial environment (mainly temperature and pressure), including a control part and a cavity part. The control part includes a programmable stepper motor controller 504, a pressure generating module 300, a stepper motor driver 502, a DC power supply 505, a serial port stepper / servo controller 503, a digital temperature control module 200, and a digital display temperature controller 501; the cavity part is composed of a main cavity 100 and a compensation cavity 400; the main cavity 100 is connected to the pressure generating module 300 through a pipeline, and the compensation cavity 400 is connected to the pressure generating module 300 through a pipeline.

[0030] In one embodiment of the present invention, an acrylic hemispherical cover 1001 is connected to the upper end of a cavity isolation plate 1003 through a sealing component 1002. Specifically, an annular crimping piece is pressed on the annular connecting portion of the acrylic hemispherical cover 1001 and is locked by screws. Fluid is input into the hemispherical cover inner cavity 1101 of the acrylic hemispherical cover 1001 through a liquid inlet pipe 1009. In order to prevent leakage of the fluid in the hemispherical cover inner cavity 1101, a sealing ring is provided at the connection between the annular connecting portion pressed on the acrylic hemispherical cover 1001 and the cavity isolation plate 1003 for sealing. A detection head 10011 is also connected to the acrylic hemispherical cover 1001. The detection head 10011 can detect the temperature and pressure of the fluid in the hemispherical cover inner cavity 1101 in real time, and can directly transmit the pressure and temperature values to the programmable stepper motor controller 504 and the digital temperature controller. The controller 501 is displayed or transmitted to the computer; the lower end of the cavity isolation plate 1003 is connected to the cavity shell 1007 by screws (to prevent leakage of the fluid in the cavity shell inner cavity 1102, a sealing ring is provided at the connection between the cavity shell 1007 and the cavity isolation plate 1003), the cavity shell 1007 is provided with a cavity shell inner cavity 1102, and the cavity shell inner cavity 1102 can be connected to the delivery pipe through a quick plug 1008 to input fluid, the hemispherical cover inner cavity 1101 and the cavity shell inner cavity 1102 are separated into two independent chambers by the cavity isolation plate 1003, and a number of micropores connecting the hemispherical cover inner cavity 1101 and the cavity shell inner cavity 1102 are evenly provided on the cavity isolation plate 1003, and the internal environment of the pressure and temperature of the fluid in the hemispherical cover inner cavity 1101 can be changed by changing the pressure and temperature of the fluid in the cavity shell inner cavity 1102.

[0031] In one embodiment of the present invention, the lower end of the cavity shell inner cavity 1102 is connected to the aluminum alloy heat conducting member 1005 by screws (in order to prevent leakage of the fluid in the cavity shell inner cavity 1102, a sealing ring is provided at the connection between the cavity shell 1007 and the aluminum alloy heat conducting member 1005), the aluminum alloy heat conducting member 1005 is provided with a plurality of heat conducting fins, and the heat conducting fins extend into the cavity shell inner cavity 1102 to fully contact with the fluid, and the lower end of the aluminum alloy heat conducting member 1005 is tightly attached to the semiconductor refrigeration module 1010, the semiconductor refrigeration module 1 010 exchanges heat with the fluid in the cavity shell cavity 1102 through the aluminum alloy heat conductor 1005, thereby changing the temperature of the fluid in the cavity shell cavity 1102, and then changing the temperature of the fluid in the hemispherical cover cavity 1101, and the semiconductor refrigeration module 1010 can be controlled by being electrically connected to the digital display temperature controller 501 through the digital temperature control module 200 (for example, directly inputting control conditions through the touch screen of the digital display temperature controller 501), or it can be connected to an external computer through the digital temperature control module 200 and controlled by the computer.

[0032] In one embodiment of the present invention, the power shaft of the motor 3001 is connected to the push head 3003 through a ball screw transmission. Specifically, the power shaft of the motor 3001 is locked with the screw shaft 3002, and the ball nut on the screw shaft 3002 is fixedly connected with a sleeve 3011. The sleeve 3011 is fixedly connected to the push head 3003 at one end close to the pressure generating cavity 3006, and a quick plug 1008 is provided on one side of the cavity shell 1007. The quick plug 1008 is connected to the quick plug 2 3007 on the pressure generating module 300 through a delivery pipe. When the motor 30 01When the push head 3003 is driven forward by the ball screw transmission, the push head 3003 passes through the central through hole of the sealing pressing plate 3004 and pushes the silicone film 3005, thereby generating pressure fluctuations on the fluid in the cavity shell inner cavity 1102, thereby changing the pressure of the fluid in the hemispherical cover inner cavity 1101, wherein the motor 3001 is driven by the stepper motor driver 502, and the stepper motor driver 502 can be directly controlled by the programmable stepper motor controller 504, or connected to a computer through the serial port stepper / servo controller 503 and controlled by the computer.

[0033] In one embodiment of the present invention, the quick plug three 3008 of the pressure generating module 300 is connected to the quick plug four 4004 of the compensation chamber 400 through a delivery pipe, and the quick plug five 4005 of the compensation chamber 400 is connected to the liquid inlet interface 506 through the delivery pipe. Fluid can be injected or pressure can be applied to the inner cavity of the compensation chamber 400, the pressure generating chamber 3006, and the inner cavity 1102 of the cavity shell through the liquid inlet interface 506. The upper end opening of the compensation chamber 4001 is connected to the silicone film two 4002 through the sealing component two 4003. Specifically, the silicone film two 4002 is pressed onto the upper end opening of the compensation chamber 4001 through an annular pressure ring and a screw. The silicone film two 4002 is elastic, making the compensation chamber 400 a flexible cavity. The human body is roughly equivalent to a sealed cavity, but this cavity is not rigid but flexible. Changes in intracranial pressure reflect this. Compensation means that even with a small amount of bleeding, intracranial pressure changes minimally because the body, as a container, is elastic and has the ability to compensate. The Compensation Cavity 400 simulates this mechanism, providing compensation for the entire sealed cavity.

[0034] Analog control principle and process:

[0035] Method 1 (manual programming, manual temperature adjustment): The user can manually write a program to control the motor through the programmable stepper motor controller 504, mainly including information such as speed, direction, and pulse. After this information is sent to the stepper motor driver 502, the stepper motor driver 502 will drive the motor 3001 to rotate a specified number of revolutions based on the received information, thereby pushing the push head 3003 forward and backward through the ball screw drive. The push head 3003 squeezes the silicone membrane 3005 of the pressure generating module 300, thereby changing the pressure in the cavity. Different speeds, directions, and pulses will produce different pressure changes. The user can combine various motion methods based on this principle to obtain the desired simulated pressure fluctuation. The user enters the desired temperature through the digital display temperature controller 501. The temperature information is sent to the digital temperature control module 200 via the RS232 serial port. The digital temperature control module 200 outputs current to the semiconductor cooling module 1010 in a bidirectional temperature control mode. Heat exchange is carried out between the semiconductor cooling module 1010 and the main cavity 100 via the aluminum alloy heat conductor 1005, thereby changing the temperature of the cavity.

[0036] Method 2 (external programming) allows users to write more complex programs on the computer. The general implementation process is as follows: the user can transmit the pressure and temperature detected in the cavity to the computer. The computer makes corresponding decisions based on the obtained pressure and temperature (simulating a real dynamic environment), and then gives and controls signals (speed, direction, pulse, temperature) to change the cavity environment. Its basic control principle is the same as that of Method 1. As can be seen from the above, Method 1 can obtain any static environment required by the user; Method 2 can write an automated program and add the user's algorithm to dynamically control the cavity environment according to the real-time environment to obtain a more realistic simulation effect.

[0037] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A programmable intracranial environment simulation device, characterized in that: The invention comprises a main cavity (100), wherein the main cavity (100) comprises a cavity isolation plate (1003), wherein the upper end of the cavity isolation plate (1003) is connected to an acrylic hemispherical cover (1001) via a sealing component (1002), and the lower end of the cavity isolation plate (1003) is connected to a cavity shell (1007) via a screw, wherein a liquid inlet hole is provided at the center of the cavity isolation plate (1003), and a lower liquid port of the liquid inlet hole is connected to a liquid inlet pipe (1009) via a liquid inlet channel component (1004), and a plurality of micropores are evenly provided on the cavity isolation plate (1003) for connecting the inner cavity of the hemispherical cover (1101) and the inner cavity of the cavity shell (1102), and the cavity shell ( A quick plug 1 (1008) is provided on one side of the cavity shell (1007), and a semiconductor refrigeration module (1010) is provided at the lower end of the cavity shell inner cavity (1102). The semiconductor refrigeration module (1010) is electrically connected to the digital temperature control module (200), and the digital temperature control module (200) is controlled by a digital display temperature controller (501) or an external computer. The quick plug 1 (1008) is connected to the pressure generating module (300) through a delivery pipe, and the pressure generating module (300) is controlled by a programmable stepping motor controller (504) or an external computer. The pressure generating module (300) is connected to the compensation cavity (400) through a delivery pipe.

2. A programmable intracranial environment simulation device according to claim 1, characterized in that: The acrylic hemispherical cover (1001) is hemispherical, an annular connecting portion is provided at the open end of the acrylic hemispherical cover (1001), and a detection head (10011) is also connected to the acrylic hemispherical cover (1001).

3. A programmable intracranial environment simulation device according to claim 2, characterized in that: The lower end of the cavity shell inner cavity (1102) is connected to an aluminum alloy heat conducting part (1005) via screws, and the lower end of the aluminum alloy heat conducting part (1005) is connected to the semiconductor refrigeration module (1010).

4. A programmable intracranial environment simulation device according to claim 3, characterized in that: The outer side of the cavity shell (1007) is fixedly connected to a fixed shell (1006); one end of the liquid inlet pipe (1009) is connected to the liquid inlet channel assembly (1004), and the other end passes through the fixed shell (1006) and extends out of the cavity; the connection between the cavity shell (1007) and the aluminum alloy heat conductor (1005), the connection between the cavity shell (1007) and the cavity isolation plate (1003), and the connection between the cavity isolation plate (1003) and the annular connection part of the acrylic hemispherical cover (1001) are all provided with sealing rings.

5. A programmable intracranial environment simulation device according to claim 4, characterized in that: The pressure generating module (300) comprises a motor bracket (3009), wherein a motor (3001) is installed at one end of the inner cavity of the motor bracket (3009), and a pressure generating cavity (3006) is provided at the other end. The power shaft of the motor (3001) is connected to the push head (3003) via a ball screw transmission. The end of the pressure generating cavity (3006) close to the push head (3003) is connected to a silicone film (3005) via a sealing pressing piece (3004). The other two ends of the pressure generating cavity (3006) are respectively provided with a quick plug (3007) and a quick plug (3008). The bottom end of the motor bracket (3009) is provided with a foot (3010).

6. A programmable intracranial environment simulation device according to claim 5, characterized in that: The quick plug one (1008) is connected to the quick plug two (3007) through a delivery tube, and the quick plug three (3008) is connected to the compensation chamber (400) through a delivery tube. The compensation chamber (400) includes a base, and a compensation chamber (4001) is provided at the upper end of the base. The upper end opening of the compensation chamber (4001) is connected to the silicone film two (4002) through the sealing component two (4003). The side of the compensation chamber (4001) is provided with a quick plug four (4004) and a quick plug five (4005). The quick plug three (3008) is connected to the quick plug four (4004) through a delivery tube, and the quick plug five (4005) is connected to the liquid inlet interface (506) through the delivery tube.

7. A programmable intracranial environment simulation device according to claim 6, characterized in that: The motor (3001) is driven by a stepper motor driver (502), the stepper motor driver (502) is electrically connected to the programmable stepper motor controller (504) and the serial port stepper / servo controller (503), and the serial port stepper / servo controller (503) is externally connected to a computer via a cable.

8. A programmable intracranial environment simulation device according to claim 7, characterized in that: The device further comprises an outer shell (600) for mounting a control portion and a cavity portion, wherein a DC power supply (505) for powering the control portion is provided inside the outer shell (600), a plurality of ventilation holes are evenly provided on the side surface of the outer shell (600), and handles (507) are symmetrically provided on two opposite side surfaces of the outer shell (600).

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