Electrolyte analysis device

Abstract

The electrolyte analysis device of the present application includes: an ISE electrode (1) including at least one electrode, a comparison electrode (2) different from the ISE electrode (1) and including at least one electrode, a housing portion (200) housing the electrodes of the ISE electrode (1) and the comparison electrode (2), the housing portion (200) having a pressing portion pressing the electrodes against each other, a first pressing switching portion (210) switching between a fixed state and a released state of the ISE electrode (1), a second pressing switching portion (215) switching between a fixed state and a released state of the comparison electrode (2), and switching between the fixed state and the released state of the ISE electrode (1) and the comparison electrode (2), respectively.

Description

Technical Field

[0001] This invention relates to an electrolyte analysis device. Background Technology

[0002] As an example of an electrolyte analysis device that prevents contamination caused by different reagents coming into contact with the suction nozzle during reagent replacement by a user, Patent Document 1 describes a device comprising: a nozzle support that is coupled with a suction nozzle and is movable between a reagent container replacement position and a reagent suction position; a locking mechanism that engages with the nozzle support moved to the reagent container replacement position and fixes the nozzle support at the reagent container replacement position; and a locking release mechanism that is capable of releasing the engagement of the nozzle support and the locking mechanism when powered on, wherein when a reagent container meets a predetermined condition, the locking release mechanism is controlled to release the engagement of the nozzle support and the locking mechanism, thereby moving the nozzle support to the reagent suction position.

[0003] Existing technical documents

[0004] Patent documents

[0005] Patent Document 1: International Publication No. 2019 / 198400 Summary of the Invention

[0006] The technical problem that the invention aims to solve

[0007] The electrolyte analysis device described in the aforementioned Patent Document 1 is a device for measuring the concentration of specific electrolytes (sodium (Na), potassium (K), chloride (Cl), etc.) contained in electrolyte solutions such as human blood and urine, and uses an ion-selective electrode to measure the concentration.

[0008] The general method for measuring electrolyte concentration mainly employs the following flow-type steps: First, serum, serving as the electrolyte solution, is directly supplied to the ion-selective electrode, or a sample solution diluted with a diluent is supplied to the ion-selective electrode, and the inter-liquid potential of the electrolyte solution with the comparison electrode solution is measured. Next, or before the above measurement, a standard solution is supplied to the ion-selective electrode, and the inter-liquid potential of the electrolyte solution with the comparison electrode solution is measured again. The electrolyte concentration of the sample solution is calculated based on the two inter-liquid potential levels.

[0009] In this type of flow electrolyte analyzer, in addition to reagents such as diluent, standard solution, and comparison electrode solution, ion-selective electrodes are used as consumables, and the replacement of these consumables is performed by the user.

[0010] Ion-selective electrodes are used in two types depending on the measurement project: measuring electrodes for Na, K, and Cl (hereinafter referred to as ISE electrodes) and comparator electrodes. Generally, the service life and number of measurements of ISE electrodes and comparator electrodes are quite different.

[0011] These ISE electrodes and comparator electrodes include flow paths with electrode membrane portions, and are used in a state where the ISE electrodes and comparator electrodes are in close contact with each other, for example, by means of O-rings, so as to prevent leakage.

[0012] When a user replaces each of these ISE electrodes and comparator electrodes, the individual electrodes can be removed by temporarily releasing the contact points between them.

[0013] On the other hand, as mentioned above, since the replacement timing of each electrode is different, even the electrode parts that are not being replaced are temporarily loosened, and internal liquid leakage cannot be avoided. In this case, in addition to the replaced electrode parts, it is also necessary to take measures such as cleaning the unreplaced electrode parts, thereby reducing the cleaning burden on the user.

[0014] This invention provides an electrolyte analysis device that reduces the burden on the user during operation compared to previous methods.

[0015] Technical means for solving technical problems

[0016] The present invention includes several means for solving the above-mentioned problems. For example, it is characterized by comprising: a first electrode group including at least one electrode; a second electrode group, different from the first electrode group and including at least one electrode; and an electrode receiving portion for receiving the electrodes of the first electrode group and the second electrode group, the electrode receiving portion having: a pressing portion for pressing the electrode; a first switching portion for switching between a fixed state and a released state of the first electrode group; and a second switching portion for switching between a fixed state and a released state of the second electrode group, and switching between the fixed state and the released state of both the first electrode group and the second electrode group.

[0017] Invention Effects

[0018] According to the present invention, the burden on the user can be reduced during job changes compared to the past. The technical problems, structures, and effects beyond those described above become clearer through the following description of embodiments. Attached Figure Description

[0019] Figure 1 A diagram showing the overall structure of the electrolyte analysis device according to Embodiment 1 of the present invention is provided.

[0020] Figure 2 This is a diagram showing a simplified structure of the analytical cell in the electrolyte analysis apparatus of Example 1.

[0021] Figure 3 This diagram shows the structure around the electrodes in the electrolyte analysis apparatus of Example 1, and shows the state in which the first electrode group and the second electrode group are fixed.

[0022] Figure 4 This is a partial perspective perspective view showing the structure around the electrodes in the electrolyte analysis device of Example 1.

[0023] Figure 5 This diagram shows the state in which the first electrode group is deactivated by the first pressing switch in the electrolyte analysis apparatus of Example 1.

[0024] Figure 6 This is a diagram showing a comparison between the fixed and unfixed states of the first electrode group in the electrolyte analysis apparatus of Example 1.

[0025] Figure 7 This diagram shows the state in which the second electrode group is deactivated by the second pressing switch in the electrolyte analysis apparatus of Example 1.

[0026] Figure 8 This is a diagram showing a comparison between the fixed and unfixed states of the second electrode group in the electrolyte analysis apparatus of Example 1.

[0027] Figure 9 This diagram illustrates the state in which the first electrode group and the second electrode group are deactivated by the first and second press-to-switch units in the electrolyte analysis apparatus of Example 1.

[0028] Figure 10 This is a diagram showing the structure around the electrodes in the electrolyte analysis apparatus of Embodiment 2 of the present invention.

[0029] Figure 11 This diagram shows the state in which the first electrode group is deactivated by the first pressing switch in the electrolyte analysis apparatus of Embodiment 2.

[0030] Figure 12 This diagram shows the state in which the second electrode group is deactivated by the second press switch in the electrolyte analysis apparatus of Embodiment 2.

[0031] Figure 13 This is a diagram showing the structure around the electrodes in the electrolyte analysis apparatus of Embodiment 3 of the present invention. Detailed Implementation

[0032] Embodiments of the electrolyte analysis apparatus of the present invention will be described below with reference to the accompanying drawings. Furthermore, in the drawings used in this specification, the same or corresponding structural elements are sometimes labeled with the same or similar reference numerals, and repeated descriptions of these structural elements are omitted.

[0033] <Example 1>

[0034] use Figures 1 to 9 Example 1 of the electrolyte analysis device of the present invention is described.

[0035] First, use Figure 1 and Figure 2 The overall structure and the structure of the main parts of the electrolyte analysis device are described. Figure 1 This is a diagram showing the overall structure of the electrolyte analysis device in Embodiment 1. Figure 2 This is a diagram showing a simplified structure of the analytical cell in an electrolyte analysis apparatus.

[0036] Figure 1 The electrolyte analysis device 100 shown includes a conveyor line 71, a clamp 55, dispensing lines 65 and 66, a pre-analysis buffer 61, a post-analysis buffer 62, two analysis tanks 50, a sample probe 14, a display device 80, a control device 29, etc.

[0037] The conveyor line 71 is located at the end of the device and is a device that uses clamps 55 to transport the conveyor container 90 to the conveyor position and remove the conveyor container 90 after the measurement is completed. The conveyor container 90 carries multiple sample containers 15 for holding samples, which are inserted from the sample holder input section (not shown).

[0038] In this embodiment, an example of mounting multiple sample containers 15 on a transfer container 90 is described, but it is sufficient to mount one or more sample containers 15 on the transfer container 90. As another example of the transfer container 90, there is a sample holder or the like capable of mounting one sample container 15.

[0039] The clamp 55 is a mechanism for moving the transfer container 90 from the transfer line 71 to the dispensing lines 65 and 66, or from the dispensing lines 65 and 66 to the transfer line 71.

[0040] Dispensing lines 65 and 66 are mechanisms for conveying the sample container 15 containing the dispensing object in the transfer container 90 to the dispensing position of the sample probe 14, or for conveying the transfer container 90 containing the dispensed sample container 15 to the post-analysis buffer 62.

[0041] The pre-analysis buffer 61 and post-analysis buffer 62 are spaces used to allow the sample container 15 waiting to be dispensed into the analysis tank 50 and the sample container 15 after the analysis is completed to wait before being transferred to other parts.

[0042] The analytical cell 50 is an analytical section equipped with an ISE electrode 1 for measuring the concentration of electrolytes in a sample. (Using...) Figure 2 The details are explained below. Furthermore, the number of analysis cells 50 provided in the electrolyte analysis apparatus 100 is not limited to one, but can be two or more.

[0043] Figure 2 The analytical cell 50 shown is a flow-type cell that uses an ion-selective electrode.

[0044] Figure 2 In the diagram, the main components of the analytical cell 50 include five parts: sample dispensing section, electrode section, reagent section, mechanism section, and waste liquid mechanism, as well as a control device 29. The control device 29 controls these parts and performs calculation and display control of electrolyte concentration based on the measurement results.

[0045] The sample dispensing section includes a sample probe 14. Patient samples, etc., held within the sample container 15, are dispensed into the analytical device by the sample probe 14. Here, "sample" is a general term for analytes collected from a patient's body, such as blood or urine. Analytes that have undergone prescribed pretreatment are also referred to as samples.

[0046] The electrode section includes a dilution tank 11, a suction nozzle 13, a diluent nozzle 24, an internal standard solution nozzle 25, an ISE electrode 1, a comparator electrode 2, a clamp valve 23, a voltmeter 27, and an amplifier 28. The sample dispensed through the sample dispensing section is discharged into the dilution tank 11 and diluted and stirred by the diluent discharged from the diluent nozzle 24 into the dilution tank 11.

[0047] The nozzle 13 is connected to the ISE electrode 1 through the first flow path, and the diluted sample solution drawn from the dilution tank 11 is transported to the ISE electrode 1 through the first flow path 37.

[0048] On the other hand, with the clamp valve 23 closed, the pipette syringe 10 is activated to deliver the comparison electrode solution contained in the comparison electrode solution bottle 5 to the comparison electrode 2 via the second flow path 38. By contacting the diluted sample solution delivered to the ISE electrode flow path with the comparison electrode solution delivered to the comparison electrode flow path, the ISE electrode 1 and the comparison electrode 2 are electrically connected. The electrode section measures the concentration of a specific electrolyte contained in the sample by the potential difference between the ISE electrode 1 and the comparison electrode 2.

[0049] Specifically, the ISE electrode 1 is attached with an ion-sensitive membrane. This membrane has the property that its electromotive force changes with the concentration of specific ions in the sample solution (e.g., sodium ions (Na+), potassium ions (K+), chloride ions (Cl-), etc.). The ISE electrode 1 outputs an electromotive force corresponding to the concentration of each ion in the sample solution, and the electromotive force between the ISE electrode 1 and the comparison electrode 2 is acquired by a voltmeter 27 and an amplifier 28. The control device 29 calculates the ion concentration in the sample based on the acquired electromotive force for each ion and displays the result. The sample solution remaining in the dilution tank 11 is discharged through a waste liquid mechanism.

[0050] Furthermore, the potential difference between the ISE electrode 1 and the comparator electrode 2 is easily affected by temperature changes. To correct for potential fluctuations caused by such temperature changes, an internal standard solution is discharged from the internal standard solution nozzle 25 into the dilution tank 11 between the measurement of one sample and the measurement of the next sample, and the measurement is performed in the same manner as for the samples described above. Preferably, the correction corresponding to the change is performed using the measurement results of the internal standard solution performed during the sample measurement. In this case, the internal standard solution is not diluted.

[0051] The reagent section includes a suction nozzle 6 for drawing reagents from the reagent container, a degassing mechanism 7, and a filter 16, and provides the reagents required for measurement. When performing electrolyte measurements, three reagents are used: an internal standard solution, a diluent, and a comparison electrode solution. The reagent section is equipped with an internal standard solution bottle 3 for containing the internal standard solution, a diluent bottle 4 for containing the diluent, and a comparison electrode solution bottle 5 for containing the comparison electrode solution. Figure 2 This state is shown. Furthermore, in the case of a cleaning device, a cleaning solution bottle for containing the cleaning solution can be placed in the reagent section.

[0052] The internal standard solution bottle 3 and the diluent bottle 4 are connected to the internal standard solution nozzle 25 and the diluent nozzle 24 respectively via a filter 16 and a flow path. Each nozzle is configured to guide its tip into the dilution tank 11. In addition, the comparison electrode solution bottle 5 is connected to the comparison electrode 2 via a filter 16 and a flow path.

[0053] Degassing mechanisms 7 are connected to the flow paths between the diluent bottle 4 and the dilution tank 11, and between the comparison electrode bottle 5 and the comparison electrode 2, respectively, to supply degassed reagent to the dilution tank 11 and the comparison electrode 2. This is because the flow path is under negative pressure using a syringe to draw reagent from the bottle, thus the gas dissolved in the reagent manifests as bubbles within the reagent. The degassing mechanisms prevent the reagent from being supplied to the dilution tank 11 and the comparison electrode 2 in a bubble-containing state.

[0054] The mechanism includes an internal standard solution injector 8, a diluent injector 9, a pipette injector 10, solenoid valves 17, 18, 19, 20, 21, 22, and 30, and a preheater 12, which perform liquid delivery operations within or between these mechanisms. For example, the internal standard solution and diluent are delivered to the dilution tank 11 by the operation of the internal standard solution injector 8, the diluent injector 9, and the solenoid valves located in the flow path. The preheater 12 suppresses the influence of temperature on the ISE electrode 1 by controlling the temperature of the internal standard solution and diluent reaching the ISE electrode 1 within a certain range.

[0055] The waste liquid mechanism includes a first waste liquid nozzle 26, a second waste liquid nozzle 36, a vacuum bottle 34, a waste liquid receiving device 35, a vacuum pump 33, and solenoid valves 31 and 32. It discharges the sample solution remaining in the dilution tank 11 and the reaction liquid remaining in the flow path of the electrode section through the third flow path.

[0056] Return to Figure 1 The display device 80 is a part that displays various screens such as the operation screen for setting the measurement items to be measured on the sample to be measured, and the screen for confirming the measurement results, and the display device 80 is composed of a liquid crystal display or the like.

[0057] In addition, it does not need to be an LCD screen; it can be replaced by a printer or the like. It can consist of a screen and a printer, and it can be a touch panel type screen that allows input of various parameters or settings, measurement results, measurement commission information, and instructions for starting or stopping the analysis based on the displayed operation screen.

[0058] The control device 29 is connected to the analysis tank 50, etc., via a wired or wireless network, and controls the operation within the electrolyte analysis apparatus 100, including the analysis tank 50. Furthermore, the control device 29 calculates the electrolyte concentration in the sample by performing calculations using the potential of the ISE electrode 1 measured against the sample solution. At this time, by calibrating based on the ISE electrode potential measured against the internal standard solution, the electrolyte concentration can be measured more accurately.

[0059] The control device 29 can be configured as a computer with a CPU (Central Processing Unit), RAM (Random Access Memory), storage devices, and I / O ports. The RAM, storage devices, and I / O ports are configured to exchange data with the CPU via an internal bus. The I / O ports are connected to the aforementioned components and control their operation. Operation control is achieved by reading programs stored in the storage devices into the RAM and executing them with the CPU. Furthermore, input / output devices are connected to the control device 29, enabling the display of user input and measurement results.

[0060] Next, the use of Figure 2 The electrolyte concentration measurement device shown is activated. The measurement action is controlled by control device 29.

[0061] First, the sample dispensed from the sample container 15 via the sample probe 14 of the sample dispensing section is discharged into the dilution tank 11 of the electrode section. After the sample is dispensed into the dilution tank 11, the diluent from the diluent bottle 4 is discharged from the diluent nozzle 24 by the action of the diluent syringe 9 to dilute the sample. As described above, in order to prevent the generation of bubbles due to temperature and pressure changes of the diluent in the flow path, degassing is performed by a degassing mechanism 7 installed in the middle of the diluent flow path. The diluted sample solution is drawn to the ISE electrode 1 by the action of the pipette syringe 10 and the solenoid valve 22.

[0062] On the other hand, the comparative electrode solution is delivered from the comparative electrode solution bottle 5 to the comparative electrode 2 via the clamp valve 23 and the pipette syringe 10. The comparative electrode solution is, for example, an aqueous solution of potassium chloride (KCl) of a specified concentration. Through contact between the sample solution and the comparative electrode solution, the ISE electrode 1 and the comparative electrode 2 are electrically connected. Furthermore, to suppress the influence of concentration fluctuations during sample delivery, the electrolyte concentration of the comparative electrode solution is preferably high; however, crystallization may occur near the saturation concentration, causing flow path blockage. Therefore, it is preferably between 0.5 mmol / L and 3.0 mmol / L. The ISE electrode potential, referenced to the comparative electrode potential, is measured using a voltmeter 27 and an amplifier 28.

[0063] In addition, before and after sample measurement, the internal standard solution in the internal standard solution bottle 3 in the reagent section is discharged into the dilution tank 11 through the internal standard solution syringe 8, and the electrolyte concentration of the internal standard solution is measured in the same way as the sample measurement.

[0064] Next, we will refer to Figures 3 to 9 The detailed structure of the analytical tank 50 of the present invention will be explained. Figure 3 This is a diagram showing the structure around the electrodes in the electrolyte analysis apparatus of Example 1. Figure 4 This is a perspective view showing the structure around the electrodes in the electrolyte analysis device of Example 1, with the internal structure partially visible through the outer wall. Figure 5 This diagram shows the state in which the first electrode group has been deactivated by the first pressing switch. Figure 6 It is a diagram comparing the fixed and unlocked states of the first electrode group. Figure 7 This diagram shows the state in which the second electrode group has been deactivated by the second press switch. Figure 8 This is a diagram comparing the fixed and unlocked states of the second electrode group. Figure 9 This diagram shows the state in which the first electrode group and the second electrode group are deactivated by the first and second press switching units.

[0065] In the electrolyte analysis device 100 of this embodiment, such as Figure 3 As shown, an ISE electrode 1, which constitutes a first electrode group including at least one electrode, and a comparison electrode 2, which constitutes a second electrode group different from the ISE electrode 1 and includes at least one electrode, are housed in a housing 200.

[0066] like Figure 3 As shown, the receiving portion 200 has a pressing portion, a first pressing switching portion 210, and a second pressing switching portion 215. Within the receiving portion 200, from... Figure 3 Starting from the left, the components are arranged in the following order: first flow path component 220, ISE electrode 1, intermediate flow path component 224, comparison electrode 2, second flow path component 222, and pressure section.

[0067] The configuration allows for switching the fixed state and the deactivated state of the ISE electrode 1 and the comparator electrode 2 via the first press switching unit 210 or the second press switching unit 215, respectively.

[0068] The first pressing switching unit 210 is a component that switches between the fixed state and the released state of the ISE electrode 1. It consists of a first component that is fixed to the holding part 245 fixed to the receiving part 200, and a second component that is provided with a rod 249A and is rotatably supported around the pressing shaft 243. The first component and the second component abut against each other through a helical surface.

[0069] If the rod 249A of the second component is in Figure 4 When rotated counterclockwise, the first and second components rotate relative to each other along the helical surface, thus extending the combined width of the first and second components in the direction of the pressing shaft 243. Conversely, by... Figure 4 Rotate lever 249A clockwise to shorten it to its original length. Both the first and second components have shaft holes that allow free axial movement relative to the pressing shaft 243. Lever 249A, located on the second component, is the first operating lever.

[0070] The second press switching unit 215 is a component that switches between the fixed state and the released state of the comparison electrode 2. It consists of a first component fixed to the slider 230 and a second component that is provided with a rod 249B as a second operating lever and is rotatably supported around the pressing shaft 243.

[0071] If the rod 249B of the second component is in Figure 4 When rotated counterclockwise, the first and second components rotate relative to each other along the helical surface, thus extending the combined width of the first and second components in the direction of the pressing shaft 243. Conversely, by... Figure 4Rotate lever 249B clockwise to shorten it to its original length. Lever 249B, located on the second component, is the second operating lever. Both the first and second components have shaft holes that allow free axial movement relative to the pressing shaft 243. The pressing shaft 243 passes through the shaft holes.

[0072] Both rods 249A and 249B extend away from the pressing axis 243, reducing the force applied to the front end of the rod when the second component is rotated along the helical surface. Furthermore, by widening the front end of the rod, a shape is created that allows the operator to easily place their fingers on it, thus providing a user-friendly electrolyte analysis device.

[0073] The first flow path member 220 is fixed to the receiving portion 200, forming a flow path connected to the first flow path 37, which is connected to the nozzle 13 and the dilution tank 11 outside the receiving portion 200. The ISE electrode 1 is pressed against the first flow path member 220 by the pressing part to maintain a fixed state during measurement.

[0074] The second flow path member 222 has a flow path connected to the second flow path 38 connected to the comparison electrode liquid bottle 5. Since it is not fixed to the receiving part 200, etc., it is configured to be able to flow to... Figure 3 The first flow path member 220 side and the first pressing switching part 210 side move.

[0075] The intermediate flow path member 224 has a groove 224A that engages with the slider 230, a flow path connected to the third flow path 39 connected to the waste liquid receiving member 35, and a pinch valve 23. Similar to the second flow path member 222, the intermediate flow path member 224 is not fixed to the receiving portion 200, etc. Therefore, the intermediate flow path member 224 is configured to be able to... Figure 3 The first flow path member 220 and the first press switching part 210 move together. The direction of pressing the ISE electrode 1 or the comparison electrode 2 by the intermediate flow path member 224 is switched by the first press switching part 210 or the second press switching part 215.

[0076] The slider 230 is disposed between the first press switching part 210 and the second press switching part 215, and is driven in coordination with the switching of the first press switching part 210 and the second press switching part 215, so that the intermediate flow path member 224 is in... Figure 3 A component that moves towards the first flow path component 220 side and the first pressing switching part 210 side.

[0077] The slider 230 is located on the first flow path component 220 side, i.e. Figure 3The front end of the left side of the middle flow path member 220 bends inward so that they are relatively close to each other. The middle flow path member 224 is provided with a groove 224A that is larger than the bend and allows the bent portion of the front end of the first flow path member 220 to be inserted. In the fixed state described later, a gap is provided between the groove 224A and the slider 230. In contrast, if the first press switching part 210 is switched, the slider 230 contacts the comparator electrode 2 near the groove 224A and keeps the comparator electrode 2 in a fixed state, and the ISE electrode 1 is switched to the deactivated state. If the second press switching part 215 is switched, the slider 230 contacts the ISE electrode 1 near the groove 224A and keeps the ISE electrode 1 in a fixed state, and the comparator electrode 2 is switched to the deactivated state.

[0078] The pressing part is a component for pressing the ISE electrode 1 and the comparison electrode 2 against each other, and includes a spring 241, a pressing shaft 243, a holding part 245, a pressing end 247, and a spring seat 248.

[0079] Spring 241 applies elastic force to spring seat 248 fixed on pressing shaft 243, in the direction of... Figure 3 The force component on the first flow path component 220 side. For example... Figure 3 As shown, an example of using a helical spring is illustrated. However, the spring 241 is not limited to a helical spring. A conical spring (which has the effect of reducing the length of the receiving part in the long side direction due to its shorter length when contracted) or other elastic members can also be used.

[0080] The pressing shaft 243 is inserted in the order of holding part 245, first pressing switching part 210, and second pressing switching part 215, and moves in the length direction of the shaft by switching the first pressing switching part 210 or the second pressing switching part 215.

[0081] The retaining part 245 is fixed to the receiving part 200 and is provided with a hole for the pressing shaft 243 to slide inside, serving as a reference surface for the first member of the first pressing switching part 210. In addition, the retaining part 245 can accept the elastic force of the spring 241.

[0082] The pressing end 247 is fixed to the pressing shaft 243 and presses the second flow path component 222.

[0083] Figure 3The diagram shows the ISE electrode 1 and the comparator electrode 2 in a fixed state, i.e., during measurement. When the ISE electrode 1 and the comparator electrode 2 are retracted, the spring 241 is in a contracted state and is in a state where the pressing end 247 is pressed by the spring seat 248 and the pressing shaft 243. That is, the pressing part applies a force to press against the first flow path member 220, and the ISE electrode 1, the intermediate flow path member 224, the comparator electrode 2, and the second flow path member 222 are fixed by being pressed against the first flow path member 220 to prevent internal liquid leakage.

[0084] A gap is provided between the slider 230 and the groove 224A of the intermediate flow path component 224, and this does not affect the fixation of the ISE electrode 1 and the comparator electrode 2.

[0085] Additionally, the second component of the first press switch unit 210 interacts with the first component and the slider 230. Figure 3 A gap is provided between the right sides of the two electrodes, which does not affect the fixation of the ISE electrode 1 and the comparison electrode 2. Furthermore, the second member of the second press switch 215 and the spring seat 248... Figure 3 A gap is provided between the left sides of the electrode and the comparator electrode 2, which does not affect the fixation of the ISE electrode 1 and the comparator electrode 2.

[0086] Figure 5 and Figure 6 This illustrates a situation where ISE electrode 1 is in a deactivated state, while comparison electrode 2 is in a fixed state. This is achieved by switching a lever mounted on the second member of the first press switch 210, as shown in the diagram. Figure 6 (A) "ISE electrode 1 and comparator electrode 2 fixed state" to Figure 6 As shown in (B) "ISE electrode 1 switching state, comparison electrode 2 fixed state", the width of the first pressing switching part 210 increases.

[0087] When the width of the first pressing switching part 210 increases, the right end face of the second component abuts against the slider 230, and the slider 230 moves to the right. The curved portion on the left end of the slider 230 also moves to the right, abutting against the right end of the groove 224A of the intermediate flow path component 224. The pressing end 247 is pressed together towards the second flow path component 222, but can no longer move towards the first flow path component 220. Therefore, the entire pressing part moves to the side opposite to the pressing end 247. At this time, since the slider 230 fixed to the second pressing switching part 215 also moves to the side opposite to the first flow path component 220, the intermediate flow path component 224 engaged with the slider 230 by the groove 224A, the comparison electrode 2 located between the intermediate flow path component 224 and the pressing end 247, and the second flow path component 222 also move together in the same direction. As a result, the ISE electrode 1 switches from the fixed state to the released state.

[0088] At this time, because the spring 241 applies a force to the pressing end 247 in the direction of pressing the comparison electrode 2 and the second flow path member 222, the comparison electrode 2 is maintained in the state where it is clamped between the intermediate flow path member 224 and the second flow path member 222 by the pressing end 247. That is, even if the ISE electrode 1 is switched from fixed to released, the fixed state of the comparison electrode 2 is maintained.

[0089] Figure 7 and Figure 8 This illustrates a situation where the ISE electrode 1 is in a fixed state, while the comparison electrode 2 is in a deactivated state. This is achieved by switching a lever mounted on the second member of the first press switch 210, as shown below. Figure 8 (A) "ISE electrode 1 and comparator electrode 2 fixed state" to Figure 8 As shown in (B) "ISE electrode 1 fixed state, comparison electrode 2 switching state", the width of the second press switching part 215 increases.

[0090] When the width of the second pressing switching part 215 increases, the slider 230 fixed to the second pressing switching part 215 is also pressed towards the first flow path member 220. The slider 230 moves towards the first flow path member 220 until it interferes with the groove 224A of the intermediate flow path member 224. After the interference, since the slider 230 can no longer move towards the first flow path member 220, the entire pressing part moves to the opposite side of the intermediate flow path member 224, and the comparison electrode 2 switches from the fixed state to the released state.

[0091] At this time, because the spring 241 applies a force to the slider 230 toward the intermediate flow path member 224, the slider 230 interferes with the groove 224A of the intermediate flow path member 224, and the intermediate flow path member 224 presses the ISE electrode 1 toward the first flow path member 220. Therefore, the ISE electrode 1 remains in a fixed state.

[0092] Figure 9 This illustrates a scenario where both ISE electrode 1 and comparator electrode 2 are in the deactivated state, as described above. Figure 5 and Figure 6 After the ISE electrode 1 shown is switched from the fixed state to the released state, as follows: Figure 7 and Figure 8 The comparison electrode 2 shown can be switched from the fixed state to the deactivated state, or in the reverse order, from the fixed state to the deactivated state.

[0093] Next, the effects of this embodiment will be explained.

[0094] The electrolyte analysis apparatus 100 of Embodiment 1 of the present invention described above includes an ISE electrode 1 containing at least one electrode, a comparison electrode 2 containing at least one electrode different from the ISE electrode 1, and a receiving portion 200 for accommodating the ISE electrode 1 and the comparison electrode 2. The receiving portion 200 has a pressing portion for pressing the electrodes against each other, a first pressing switching portion 210 for switching between a fixed state and a released state of the ISE electrode 1, and a second pressing switching portion 215 for switching between a fixed state and a released state of the comparison electrode 2, and switches between the fixed state and the released state of the ISE electrode 1 and the comparison electrode 2, respectively.

[0095] Therefore, for example, when installing or removing the ISE electrode 1, the pressure on the ISE electrode 1 can be released while maintaining the tight fit of the comparator electrode 2, allowing for the installation and removal of both the ISE electrode 1 and the comparator electrode 2 while keeping the other side fixed. Thus, compared to conventional methods, this reduces the number of leakage points, and since cleaning of the fixed side is unnecessary, the burden on the user is significantly reduced during replacement operations compared to conventional device structures.

[0096] Furthermore, since both the ISE electrode 1 and the comparison electrode 2 can be removed simultaneously, all electrodes can be removed. Therefore, an electrolyte analysis device can be provided that allows for easy cleaning of the entire interior of the housing 200, and offers excellent cleanability and ease of use.

[0097] In this embodiment, the lever 249A, which is operated when assembling or disassembling the ISE electrode 1, and the lever 249B, which is operated when assembling or disassembling the comparison electrode 2, are arranged adjacent to each other. Therefore, when replacing either electrode, the operator can simply reach to approximately the same location. Furthermore, if the two levers are configured to rotate in the same direction for assembly or disassembly, the assembly and disassembly actions are identical, thus improving operability.

[0098] In addition, for example, such as Figure 3 As shown, by placing the ISE electrode 1 on the left and the comparison electrode 2 on the right, and by placing the lever 249A for installing and removing the ISE electrode 1 on the left and the lever 249B for installing and removing the comparison electrode 2 on the right, the arrangement of the levers corresponding to the electrode arrangement is the same, thereby providing an electrolyte analysis device that can reduce operational errors and has good operability.

[0099] <Example 2>

[0100] use Figures 10 to 12 The electrolyte analysis device of Embodiment 2 of the present invention is described. Figure 10 This is a diagram showing the structure around the electrodes in the electrolyte analysis apparatus of Example 2. Figure 11This diagram shows the state in which the first electrode group is deactivated by the first pressing switch. Figure 12 This diagram shows the state in which the second electrode group is deactivated by the second pressing switch.

[0101] In the electrolyte analysis device 100 of Example 1, the spring 241 is positioned at the outermost end, in contrast to, as Figure 10 As shown, in the analysis tank 50 of the electrolyte analysis apparatus 100 of this embodiment, the pressing part includes a spring 341, a pressing shaft 343, a holding part 345, and pressing ends 347 and 348. Moreover, the spring 341 is disposed between the holding part 345 and the pressing end 347, the pressing end 347 constitutes the end on the side of the second flow path member 322, and the pressing end 348 constitutes the other end.

[0102] The other receiving portion 300, first pressing switching portion 310, second pressing switching portion 315, first flow path member 320, second flow path member 322, intermediate flow path member 324 and its groove 324A, pressing shaft 343, and holding portion 345 have substantially the same structure as the receiving portion 200, first pressing switching portion 210, second pressing switching portion 215, first flow path member 220, second flow path member 222, intermediate flow path member 224 and its groove 224A, pressing shaft 243, and holding portion 245 in Embodiment 1.

[0103] In this embodiment, as Figure 11 As shown, by switching the lever of the second member of the first pressing switching part 310, the width of the first pressing switching part 310 increases. The right end face of the second member abuts against the slider 330, causing the slider 330 to move to the right. The curved portion on the left end of the slider 330 also moves to the right, causing it to abut against the right end of the groove 324A of the intermediate flow path member 324. At this time, the pressing end 347 is pressed towards the second flow path member 322, but cannot move further, so the entire pressing part moves to the side opposite to the second flow path member 322. At this time, since the slider 330 also moves to the side opposite to the second flow path member 322, the intermediate flow path member 324, the comparison electrode 2, and the second flow path member 322, which are engaged with the slider 330 by the groove 324A, also move in the same direction as the slider 330. Thus, the ISE electrode 1 switches from the fixed state to the released state.

[0104] In contrast, since the spring 341 applies a force toward the second flow path member 322 to the pressing part, the comparison electrode 2 is still pressed onto the intermediate flow path member 324 by the pressing end 347 of the pressing part. Therefore, even when the ISE electrode 1 is switched to the release state, the comparison electrode 2 remains in a fixed state.

[0105] In addition, such as Figure 12As shown, by switching the second member of the second pressing switching part 315 using a lever, the width of the second pressing switching part 315 increases. At this time, the slider 330 fixed to the second pressing switching part 315 is pressed towards the first flow path member 320 side, and the slider 330 moves towards the first flow path member 320 side until it interferes with the groove 324A of the intermediate flow path member 324. After the interference, since it can no longer move towards the first flow path member 320 side, the entire pressing part moves to the opposite side of the intermediate flow path member 324 side, and the comparison electrode 2 switches from the fixed state to the released state.

[0106] At this time, because a force is applied to the slider 330 towards the intermediate flow path member 324 via the spring 341, the slider 330 interferes with the groove 324A of the intermediate flow path member 324, and the intermediate flow path member 324 presses the ISE electrode 1 towards the first flow path member 320. Therefore, the ISE electrode 1 remains in a fixed state.

[0107] Other structures and operations are substantially the same as those of the electrolyte analysis device in Example 1 above, and their details are omitted.

[0108] The electrolyte analysis device of Embodiment 2 of the present invention can also achieve essentially the same effect as the electrolyte analysis device of Embodiment 1 described above.

[0109] <Example 3>

[0110] use Figure 13 The electrolyte analysis device of Embodiment 3 of the present invention is described. Figure 13 This is a diagram showing the structure around the electrodes in the electrolyte analysis apparatus of Example 3.

[0111] like Figure 13 As shown, the electrolyte analyzer 100 in this embodiment has the same structure in the receiving part 400 as the ISE electrode 1 and the comparison electrode 2, but the structure of the pressing part is different from that in embodiments 1 and 2.

[0112] like Figure 13 As shown, the pressing part in the receiving part 400 of this embodiment is composed of a first pressing part into which a first pressing switching part 410 is inserted, and a second pressing part into which a second pressing switching part 415 is inserted. The intermediate flow path member 424 is fixed to the receiving part 400.

[0113] The first pressing part includes a pressing shaft 443A into which the first pressing switching part 410 is inserted, pressing ends 447A and 448A fixed to the pressing shaft 443A, etc., and is not fixed to the receiving part 400 except for the holding part 445A. A spring 441A that applies force in a predetermined direction is provided between the pressing end 447A and the holding part 445A.

[0114] The second pressing part includes a pressing shaft 443B into which the second pressing switching part 415 is inserted, pressing ends 447B and 448B fixed to the pressing shaft 443B, etc., and is not fixed to the receiving part 400 except for the holding part 445B. A spring 441B that applies force in a predetermined direction is provided between the pressing end 447B and the holding part 445B.

[0115] In this embodiment, under normal conditions, the ISE electrode 1 and the first flow path member 420 are pressed against the intermediate flow path member 424 fixed to the receiving portion 400 by a spring 441A via a pressing end 447A, thereby maintaining the fixed state of the ISE electrode 1. Additionally, the comparison electrode 2 and the second flow path member 422 are pressed against the intermediate flow path member 424 by a spring 441B via a pressing end 447B, thereby maintaining the comparison electrode 2 in a fixed state.

[0116] When the ISE electrode 1 is switched from the fixed state to the released state, the width of the first press switching part 410 is increased by switching the lever of the second member of the first press switching part 410, causing the pressing end 448A to move to the left as shown in the figure, that is, away from the holding part 445A. As a result, the pressing end 447A separates from the first flow path member 420, so the pressing force of the ISE electrode 1 on the intermediate flow path member 424 disappears, and it is in the released state. At this time, the state of the comparison electrode 2 side does not change, so it remains in the fixed state.

[0117] When the comparator electrode 2 is switched from the fixed state to the released state, the width of the second press switching part 415 is increased by switching the lever of the second member of the second press switching part 415, causing the pressing end 448B to move to the right as shown in the figure, that is, away from the holding part 445B. As a result, the pressing end 447B separates from the second flow path member 422, and therefore the pressing force of the comparator electrode 2 on the intermediate flow path member 424 disappears, and it is in the released state. At this time, the state of the ISE electrode 1 side does not change, so it remains in the fixed state.

[0118] Other structures and operations are substantially the same as those of the electrolyte analysis device in Example 1 above, and their details are omitted.

[0119] The electrolyte analysis device with a pressing part having a first pressing part with a first pressing switching part 410 inserted and a second pressing part with a second pressing switching part 415 inserted, as in Embodiment 3 of the present invention, can also achieve approximately the same effect as the electrolyte analysis device of Embodiment 1 described above.

[0120] Furthermore, in Embodiment 3, the first rod operated when installing or removing the ISE electrode 1 and the second rod operated when installing or removing the comparison electrode 2 are positioned opposite each other in the receiving portion 300. Since the first rod is positioned adjacent to the ISE electrode 1 and the second rod is positioned adjacent to the comparison electrode 2, they are close to the electrodes to be installed and removed, respectively. Therefore, an electrolyte analysis device that is easy to use and allows for easy determination of the correspondence between the electrode to be installed / removed and the rod to be operated is provided.

[0121] <Other>

[0122] This invention is not limited to the embodiments described above, but also includes various modifications. For example, the above embodiments are detailed descriptions provided to facilitate understanding of the invention, and the invention is not necessarily limited to including all the structures described.

[0123] Furthermore, a portion of the structure in one embodiment can be replaced with the structure in another embodiment, or the structure in another embodiment can be added to the structure in one embodiment. Additionally, other structures can be added to, deleted from, or replaced with portions of the structure in each embodiment.

[0124] Label Explanation

[0125] 1ISE electrode (Electrode Group 1)

[0126] 2. Comparison electrode (second electrode group)

[0127] 3 Internal standard solution bottles

[0128] 4 diluent bottles

[0129] 5 Comparison electrode liquid bottle

[0130] 6 suction nozzles

[0131] 7 Degassing Mechanism

[0132] 8 Internal standard solution syringe

[0133] 9 Diluent Syringe

[0134] 10…pipe syringe

[0135] 11 Dilution Tanks

[0136] 12 preheaters

[0137] 13 suction nozzles

[0138] 14 sample probes

[0139] 15 Sample Containers

[0140] 16 filters

[0141] Solenoid valves 17, 18, 19, 20, 21, 22, 30, 31, 32

[0142] 23 Pinch Valve

[0143] 24 diluent nozzle

[0144] 25 Internal Standard Liquid Nozzle

[0145] 26 First waste liquid nozzle

[0146] 27 Voltmeter

[0147] 28 amplifier

[0148] 29. Control Device (Control Unit)

[0149] 33 Vacuum Pump

[0150] 34 vacuum bottles

[0151] 35 Waste Liquid Receiving Unit

[0152] 36 Second waste liquid nozzle

[0153] 37 1st flow path

[0154] 38 2nd flow path

[0155] 39 3rd flow path

[0156] 50 analysis tanks

[0157] 55 clamp

[0158] 61 Analysis of the pre-buffer zone

[0159] 62 Post-analysis buffer

[0160] 65, 66 points betting line

[0161] 71 Teleport Line

[0162] 80 display devices

[0163] 90 Transport Containers

[0164] 100 Electrolyte Analysis Device

[0165] 200, 300, 400 electrode housings

[0166] 210, 310, 410 First Press Switching Unit (First Switching Unit)

[0167] 215, 315, 415 Second Press Switching Unit (Second Switching Unit)

[0168] 220, 320, 420 First flow path components

[0169] 222, 322, 422, second flow path components

[0170] 224, 324, 424 intermediate flow path components (3rd flow path component)

[0171] 224A, 324A slots

[0172] 230, 330 sliders

[0173] 241, 341, 441A, 441B springs (pressing part, elastic body)

[0174] 243, 343, 443A, 443B Pressing Shaft (Pressing Part, Shaft Part)

[0175] 245, 345, 445A, 445B retaining parts (pressing parts, holding parts)

[0176] 247, 347, 348, 447A, 447B, 448A, 448B Pressing end (pressing part)

[0177] 248 spring seat

[0178] 249A and 249B levers (operating levers).

Claims

1. An electrolyte analysis device, characterized by, comprises: a first electrode group including at least one electrode; a second electrode group different from the first electrode group and including at least one electrode; and an electrode housing portion for housing the electrodes of the first electrode group and the second electrode group, the electrode housing portion has: a pressing portion for pressing the electrodes to each other; a first switching portion that switches between a fixed state and a released state of the first electrode group; a second switching portion that switches between a fixed state and a released state of the second electrode group; a first flow path member that forms a first flow path connected to the outside of the electrode housing portion; a second flow path member connected to a second flow path; and a third flow path member connected to a third flow path, arranged in the order of the first flow path member, the first electrode group, the third flow path member, the second electrode group, the second flow path member, and the pressing portion, switched between the fixed state and the released state of the first electrode group and the second electrode group, respectively, the first electrode group is fixed by being pressed by the pressing portion to the first flow path member, the direction in which the first electrode group or the second electrode group is pressed by the third flow path member is switched by the first switching portion or the second switching portion, the first flow path member is fixed to the electrode housing portion, the pressing portion has: a shaft portion inserted in the order of a holding portion, the first switching portion, and the second switching portion; an elastic body that exerts a force on the shaft portion in a predetermined direction; and a holding portion fixed to the electrode housing portion, capable of receiving the elastic force of the elastic body and axially supporting the shaft portion so as to be movable in the axial direction, a slider that moves the third flow path member is provided between the first switching portion and the second switching portion, and the slider is fixed to the second switching portion.

2. The electrolyte analysis device according to claim 1, wherein the third flow path member has a groove engaged with the slider, a gap is provided between the groove and the slider when the first electrode group is pressed to the first flow path member, if the first switching portion is switched, the slider comes into contact with the groove and switches the first electrode group to the released state while the second electrode group is kept in the fixed state, and if the second switching portion is switched, the slider comes into contact with the groove and switches the second electrode group to the released state while the first electrode group is kept in the fixed state.

3. The electrolyte analysis device according to claim 1, wherein a first operation lever for operating the first switching portion and a second operation lever for operating the second switching portion are arranged adjacent to each other. ​ ​ ​

Images