A ginseng and deer antler pill for treating oligospermia and its preparation method

Abstract

This invention discloses a ginseng and deer antler pill and its preparation method, belonging to the field of traditional Chinese medicine preparation technology. The ginseng and deer antler pill comprises active ingredients and pharmaceutical excipients; wherein, the active ingredients, by mass parts, include: 9-11 parts ginseng, 15-17 parts deer antler, 11-13 parts tortoise shell, 9-11 parts donkey-hide gelatin, 15-17 parts motherwort, 15-17 parts morinda root, 15-17 parts angelica root, 15-17 parts eucommia bark, 15-17 parts achyranthes root, 15-17 parts poria cocos, 15-17 parts dodder seed, 15-17 parts astragalus root, 15-17 parts longan pulp, 15-17 parts schisandra fruit, 15-17 parts phellodendron bark, 15-17 parts cyperus rhizome, and 4-5 parts cordyceps. This invention enhances the blood-nourishing and sperm-generating effects of the original formula by adding tortoise shell and donkey-hide gelatin to the traditional ginseng and deer antler pill formula, and by replacing psoralea corylifolia with motherwort in the formula, resulting in a significant therapeutic effect on oligospermia.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a ginseng and deer antler pill and its preparation method. Background Technology

[0002] Ginseng and Deer Antler Pills are a traditional Chinese medicine compound preparation made from 15 medicinal materials including ginseng, deer antler, angelica, astragalus, psoralea, and cordyceps. Its main functions are to nourish the kidneys and promote the production of body fluids, replenish qi, and nourish blood.

[0003] Oligospermia refers to a condition where the number of sperm in the semen of a healthy, fertile man is lower than that of a normal sperm count. Clinical manifestations include low sperm motility, poor forward movement, and a high rate of sperm abnormalities. Oligospermia is a relatively common cause of male infertility.

[0004] In modern work and life, due to factors such as frequent late nights, high work pressure leading to mental stress, and lack of exercise, sperm motility is decreasing, resulting in an increasing trend of oligospermia. Ginseng and deer antler pills, as one of the traditional Chinese medicine preparations currently used to treat oligospermia, have only moderate efficacy. How to improve the traditional formula of ginseng and deer antler pills to enhance its therapeutic effect on oligospermia is a direction that research in this field should focus on. Summary of the Invention

[0005] The purpose of this invention is to provide a ginseng and deer antler pill and its preparation method. By adding tortoise shell and donkey-hide gelatin, which are considered to have nourishing properties, to the traditional ginseng and deer antler pill formula, and replacing psoralea corylifolia with motherwort, the blood-nourishing and sperm-generating effects of the original formula are enhanced, and the therapeutic effect on oligospermia is more significant.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] One of the technical solutions of this invention is to provide a ginseng and deer antler pill, the components of which include active ingredients and pharmaceutical excipients for pills;

[0008] The active ingredients, by mass parts, include: 9-11 parts ginseng, 15-17 parts deer antler, 11-13 parts tortoise shell, 9-11 parts donkey-hide gelatin, 15-17 parts motherwort, 15-17 parts morinda root, 15-17 parts angelica root, 15-17 parts eucommia bark, 15-17 parts achyranthes root, 15-17 parts poria cocos, 15-17 parts dodder seed, 15-17 parts astragalus root, 15-17 parts longan pulp, 15-17 parts schisandra fruit, 15-17 parts phellodendron bark, 15-17 parts cyperus rhizome, and 4-5 parts cordyceps.

[0009] This formula uses ginseng to replenish vital energy and nourish blood, donkey-hide gelatin to nourish blood and yin, and tortoise shell to nourish yin and subdue yang, seeking yang within yin, so that yang can generate endless vitality with the help of yin. Deer antler tonifies the kidneys and strengthens yang, nourishes essence and blood, thus harmonizing qi, blood, yin and yang, and supplementing both acquired and innate constitutions; these are the principal herbs. Astragalus, Poria, Angelica sinensis, and longan pulp replenish qi and nourish blood, and calm the mind; Morinda officinalis, Cordyceps sinensis, Achyranthes bidentata, and Leonurus japonicus nourish yin and generate essence, and strengthen muscles and bones; Schisandra chinensis replenishes qi and nourishes yin, astringes essence and stops seminal emission, and calms the mind; Cuscuta chinensis and Eucommia ulmoides warm yang and raise yin, so that yin can generate endless vitality with the rise of yang; these are the assistant herbs. Cyperus rotundus regulates qi and soothes the liver, regulates menstruation and relieves pain, so that the tonification is not stagnant; Phellodendron amurense is bitter and cold, and strengthens yin, thus counteracting the dryness of the other herbs; these are the adjuvant herbs. The combined effects of these herbs are to nourish blood and generate essence.

[0010] Preferably, the active ingredients, by mass parts, include: 10 parts ginseng, 16 parts deer antler, 12 parts tortoise shell, 10 parts donkey-hide gelatin, 16 parts motherwort, 16 parts morinda root, 16 parts angelica, 16 parts eucommia, 16 parts achyranthes root, 16 parts poria, 16 parts dodder seed, 16 parts astragalus, 16 parts longan pulp, 16 parts schisandra fruit, 16 parts phellodendron bark, 16 parts cyperus rhizome, and 4 parts cordyceps.

[0011] Preferably, the deer antler is dehaired and processed with ghee; the Morinda officinalis is processed with licorice water; the Cuscuta chinensis is salt-fried; the Astragalus membranaceus is honey-roasted; the Schisandra chinensis is vinegar-steamed; and the Cyperus rotundus is vinegar-processed.

[0012] Preferably, the pharmaceutical excipients for the pills include honey.

[0013] The second technical solution of the present invention provides a method for preparing the above-mentioned ginseng and deer antler pills, comprising the following steps:

[0014] Ginseng, deer antler, tortoise shell, motherwort, morinda root, angelica, eucommia bark, achyranthes root, poria cocos, dodder seed, astragalus root, longan pulp, schisandra fruit, phellodendron bark, cyperus rhizome, and cordyceps are pulverized, sieved, and sterilized to obtain a total mixed medicinal powder. The total mixed medicinal powder is then mixed with melted donkey-hide gelatin and pill-making excipients, followed by mixing, drying, and pill-making to obtain the ginseng and deer antler pills.

[0015] Preferably, the ginseng, deer antler, tortoise shell, motherwort, morinda root, angelica, eucommia, achyranthes root, poria, dodder seed, astragalus, longan pulp, schisandra fruit, phellodendron bark, cyperus rhizome, and cordyceps are pulverized and sieved through a 100-mesh sieve.

[0016] Preferably, the melting temperature is 80–100°C.

[0017] Preferably, the temperature of the agglomerate is 80–90°C.

[0018] The beneficial technical effects of the present invention are as follows:

[0019] This invention provides a formula for ginseng and deer antler pills. By adding tortoise shell and donkey-hide gelatin, which are considered nourishing and beneficial to the body, to the traditional ginseng and deer antler pill formula, and replacing psoralea corylifolia with motherwort, the overall approach is to use the assistant herbs to warm the yang and nourish the yin, thereby enhancing the yin-nourishing effects of the principal herbs, donkey-hide gelatin and tortoise shell. By seeking yang within yin, the deer antler, the principal herb, benefits from the yin and is thus able to generate abundant essence, greatly enhancing the blood-nourishing and sperm-producing effects of the original formula. Compared with traditional ginseng and deer antler pills, this formula is more effective in treating oligospermia. Detailed Implementation

[0020] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention. It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the present invention.

[0021] Furthermore, regarding the numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, are also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0022] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar to or equivalent to those described herein may be used in the implementation or testing of this invention.

[0023] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0024] All raw materials used in the embodiments of this invention are commercially available products.

[0025] Example 1

[0026] Preparation of Ginseng and Deer Antler Pills (large honey pills):

[0027] (1) Take the following weights of Chinese herbal medicine slices:

[0028] Ginseng 50g, deer antler (hair removed, processed with ghee) 80g, tortoise shell 60g, motherwort 80g, morinda root (processed with licorice water) 80g, angelica root 80g, eucommia bark 80g, achyranthes root 80g, poria cocos 80g, dodder seed (salt-fried) 80g, astragalus root (honey-fried) 80g, longan pulp 80g, schisandra fruit (vinegar-steamed) 80g, phellodendron bark 80g, cyperus rhizome (vinegar-processed) 80g, and cordyceps sinensis 20g;

[0029] The prepared Chinese herbal medicine slices are added to a multi-stage pulverizer and pulverized until they pass through a 100-mesh sieve. Then, using... 60 The total powder mixture was irradiated with Co, and the irradiation dose did not exceed 3 kGy to obtain the total powder mixture.

[0030] (2) Heat the honey to 105-115℃ and refine it until the water content is 18-20%. Stop when the honey is soft and filter it through a 50-mesh sieve. Let it stand at 80-90℃ for use in mixing.

[0031] (3) Take 50g of donkey-hide gelatin and add 50mL of hot water at 80-100℃ to dissolve it;

[0032] (4) Mix the sterilized total mixed medicine powder from step (1) with the tender honey from step (2) (add 130g tender honey for every 100g total mixed medicine powder), place it in a trough mixer, add the melted donkey-hide gelatin, start the trough mixer to stir, stir for about 10 minutes, mix evenly, form soft and hard pills, no dry powder, no floating honey, take them out and place them on a stainless steel trough, transfer them to the drying room to dry until suitable for pill making;

[0033] (5) The pill making is carried out on the honey pill machine. Apply an appropriate amount of lubricating oil to the chain with a brush, add the medicine ball into the feed port, squeeze out the strip, rotate, cut into smooth spherical honey pills, each weighing 9g, and make ginseng and deer antler pills.

[0034] Example 2

[0035] Preparation of Ginseng and Deer Antler Pills (Traditional Ginseng and Deer Antler Pill Formula):

[0036] (1) Take the following weights of Chinese herbal medicine slices:

[0037] Ginseng 50g, deer antler (hair removed, processed with ghee) 80g, psoralea corylifolia (salt-fried) 80g, morinda officinalis (licorice water processed) 80g, angelica sinensis 80g, eucommia ulmoides 80g, achyranthes bidentata 80g, poria cocos 80g, cuscuta chinensis (salt-fried) 80g, astragalus membranaceus (honey-fried) 80g, longan pulp 80g, schisandra chinensis (vinegar-steamed) 80g, phellodendron chinense 80g, cyperus rotundus (vinegar-processed) 80g, and cordyceps sinensis 20g;

[0038] The prepared Chinese herbal medicine slices are added to a multi-stage pulverizer and pulverized until they pass through a 100-mesh sieve. Then, using... 60 The total powder mixture was irradiated with Co, and the irradiation dose did not exceed 3 kGy to obtain the total powder mixture.

[0039] (2) Heat the honey to 105-115℃ and refine it until the water content is 18-20%. Stop when the honey is soft and filter it through a 50-mesh sieve. Let it stand at 80-90℃ for use in mixing.

[0040] (3) Mix the total mixed powder sterilized in step (1) with the tender honey in step (2) (add 130g tender honey for every 100g total mixed powder), place it in a trough mixer, start the trough mixer to stir, stir for about 10 minutes, mix evenly, form soft and hard pellets, no dry powder, no floating honey, take it out and place it on a stainless steel trough, transfer it to the drying room to dry until it is suitable for making pellets;

[0041] (4) The pill making is carried out on the honey pill machine. Apply an appropriate amount of lubricating oil to the chain with a brush, add the medicine ball into the feed port, squeeze out the strip, rotate, cut into smooth spherical honey pills, each weighing 9g, and make ginseng and deer antler pills.

[0042] Comparing the therapeutic effects of the ginseng and deer antler pills prepared in Examples 1 and 2 on oligospermia:

[0043] Diagnostic criteria for oligospermia:

[0044] After abstinence for 3-7 days, men should undergo three routine semen analyses. The average sperm density should be below 20 million sperm per mL, with no inflammation, cryptorchidism, or varicocele. A sperm count of 10-20 million sperm per mL is considered mild oligospermia, 5-10 million sperm per mL is moderate oligospermia, and below 5 million sperm per mL is severe oligospermia.

[0045] Treatment methods:

[0046] The trial involved 40 volunteers, divided into two groups of 20 each. Each group took one pill twice daily, one pill prepared according to Example 1 and the other according to Example 2. Semen analysis was performed after two weeks of treatment.

[0047] Therapeutic criteria:

[0048] The patient was cured; after routine semen analysis, the average sperm density was above 20 million / mL.

[0049] Effective, transforming severe oligospermia into moderate or mild oligospermia or curing it; transforming moderate oligospermia into mild oligospermia or curing it.

[0050] Ineffective; the number of sperm in the semen did not improve before and after treatment.

[0051] The treatment outcomes of patients in Example 1 and Example 2 are shown in Table 1.

[0052] Table 1 Treatment status of patients with oligospermia

[0053]

[0054]

[0055] Table 1 shows that by adjusting the traditional formula of Ginseng and Deer Antler Pills (large honey pills), the resulting new formula significantly improves the overall effective rate and cure rate for patients with oligospermia. Practice has proven that the formulation approach of this invention is scientifically effective and can provide a new treatment strategy for patients with oligospermia.

[0056] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A ginseng and deer antler pill for treating oligospermia, characterized in that, The components include the active ingredients and pharmaceutical excipients for pills; The active ingredients, by mass parts, are: 9-11 parts ginseng, 15-17 parts deer antler, 11-13 parts tortoise shell, 9-11 parts donkey-hide gelatin, 15-17 parts motherwort, 15-17 parts morinda root, 15-17 parts angelica root, 15-17 parts eucommia bark, 15-17 parts achyranthes root, 15-17 parts poria cocos, 15-17 parts dodder seed, 15-17 parts astragalus root, 15-17 parts longan pulp, 15-17 parts schisandra fruit, 15-17 parts phellodendron bark, 15-17 parts cyperus rhizome, and 4-5 parts cordyceps.

2. The ginseng and deer antler pill formulation according to claim 1, characterized in that, The active ingredients, by mass parts, are: 10 parts ginseng, 16 parts deer antler, 12 parts tortoise shell, 10 parts donkey-hide gelatin, 16 parts motherwort, 16 parts morinda root, 16 parts angelica, 16 parts eucommia, 16 parts achyranthes, 16 parts poria, 16 parts dodder seed, 16 parts astragalus, 16 parts longan pulp, 16 parts schisandra fruit, 16 parts phellodendron bark, 16 parts cyperus rhizome, and 4 parts cordyceps.

3. The ginseng and deer antler pills according to claim 1 or 2, characterized in that, The deer antler is dehaired and processed with ghee; the Morinda officinalis is processed with licorice water; the Cuscuta chinensis is salt-fried; the Astragalus membranaceus is honey-processed; the Schisandra chinensis is vinegar-steamed; and the Cyperus rotundus is vinegar-processed.

4. The ginseng and deer antler pills according to claim 1 or 2, characterized in that, The pharmaceutical excipients used in the pills include honey.

5. A method for preparing ginseng and deer antler pills according to any one of claims 1 to 4, characterized in that, Includes the following steps: Ginseng, deer antler, tortoise shell, motherwort, morinda root, angelica, eucommia bark, achyranthes root, poria cocos, dodder seed, astragalus root, longan pulp, schisandra fruit, phellodendron bark, cyperus rhizome, and cordyceps are pulverized, sieved, and sterilized to obtain a total mixed medicinal powder. The total mixed medicinal powder is then mixed with melted donkey-hide gelatin and pill-making excipients, followed by mixing, drying, and pill-making to obtain the ginseng and deer antler pills.

6. The preparation method according to claim 5, characterized in that, The ginseng, deer antler, tortoise shell, motherwort, morinda root, angelica, eucommia bark, achyranthes root, poria cocos, dodder seed, astragalus root, longan pulp, schisandra fruit, phellodendron bark, cyperus rhizome, and cordyceps sinensis are pulverized and sieved through a 100-mesh sieve.

7. The preparation method according to claim 5, characterized in that, The melting temperature is 80~100℃.

8. The preparation method according to claim 5, characterized in that, The temperature of the agglomerate is 80~90℃.

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