Essential oil composition and use thereof

Abstract

The present application provides a kind of essential oil composition, belongs to daily chemical technology field.The essential oil composition of the present application includes the following components by weight: 30-50 parts of yizhi essential oil, 20-40 parts of lion head citrus essential oil, 15-30 parts of cumin seed essential oil.The essential oil composition of the present application is synergistically enhanced under the action of various active ingredients.The essential oil composition of the present application is used as the main functional component of mosquito repellent, which has the advantages of natural, green, safe, no side effects, no pollution, etc., and lays the foundation for the development of green and environmentally friendly plant-based mosquito repellent products.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of daily chemical industry, and particularly relates to an essential oil composition and application thereof in mosquito repellent. BACKGROUND

[0002] Mosquitoes are carriers of various mosquito-borne infectious disease pathogens, and their saliva contains various antigen components. Female mosquitoes suck the blood of humans or animals when they reproduce, causing insect bite dermatitis at the bitten site and accompanying the uncomfortable feeling of skin itching. In addition, mosquitoes can also transmit various diseases such as malaria, dengue fever, yellow fever, etc. In recent years, the number of people suffering from diseases and even death due to mosquito bites has shown an upward trend. With global warming, the time and area suitable for the survival of mosquitoes are more extensive, and various infectious diseases caused by mosquito-borne pathogens are likely to enter an unprecedented outbreak period.

[0003] At present, using mosquito repellents is one of the effective measures to avoid mosquito bites. Mosquito repellents can cause the smell receptors of mosquitoes to malfunction, causing mosquitoes to fail to identify humans as blood-sucking targets, and play a key role in preventing bites and disease transmission. According to the different components of the repellent, it is mainly divided into two categories of chemical synthesis and plant origin, and the commonly used repellents on the market are mainly chemical synthesis. The large-scale use of chemical repellents has led to the emergence of drug-resistant mosquitoes, which has brought greater challenges to the effective control of mosquitoes and related diseases.

[0004] With the increase of market demand, the types of mosquito repellent products are increasing, and people's requirements for the effectiveness and safety of mosquito repellent products are also increasing. Therefore, green and environmentally friendly plant source repellents have become a hot research topic at present. SUMMARY

[0005] Therefore, the purpose of the present application is to provide an essential oil composition which can be used to prepare a plant source green mosquito repellent product, has high safety and good mosquito repellent effect.

[0006] In order to achieve the above-mentioned purpose of the application, the present application provides the following technical solutions:

[0007] An essential oil composition comprises the following components in parts by weight: 30-50 parts of Chinese yam seed oil, 20-40 parts of lion head citrus oil, and 15-30 parts of coriander seed oil.

[0008] Preferably, the essential oil composition comprises the following components in parts by weight: 35-45 parts of Chinese yam seed oil, 25-30 parts of lion head citrus oil, and 20-25 parts of coriander seed oil.

[0009] Another purpose of the present application is to provide a mosquito repellent product comprising the essential oil composition.

[0010] Preferably, the weight percentage of the essential oil composition in the mosquito repellent product is 5-20%.

[0011] Preferably, the mosquito repellent product further comprises a surfactant, and the surfactant comprises any one or several of Tween, hydrogenated castor oil and alkyl glucoside.

[0012] Preferably, the mosquito repellent product further comprises an organic solvent, and the organic solvent is de-aldehyde ethanol.

[0013] Another object of the present application is to provide a preparation method of the mosquito repellent product, comprising the following steps: weighing the essential oil of Alpinia oxyphylla, the essential oil of Citrus aurantium and the essential oil of Coriandrum sativum seed according to the proportion, mixing and stirring uniformly, adding a surfactant and stirring uniformly, adding an organic solvent, and ultrasonic treatment to obtain the mosquito repellent product.

[0014] Preferably, the ultrasonic treatment temperature is 20-50℃, the treatment time is 10-30min, and the ultrasonic power is 200-1000W.

[0015] Another object of the present application is to provide the application of the essential oil composition or the mosquito repellent product in repelling mosquitoes.

[0016] Preferably, the essential oil composition or the mosquito repellent product is used every 5-7h.

[0017] Compared with the prior art, the present application has the following beneficial effects:

[0018] The present application provides an essential oil composition, and the essential oil composition of the present application is rich in various bioactive substances, including various terpenoid components such as round limettin, limonene, citronellal and linalool, which have a significant synergistic effect on mosquito repellency. The present application uses natural plant essential oil, which has a repellent effect on mosquitoes, can inhibit the growth and development of mosquitoes, and even can kill mosquitoes, larvae and their eggs. The present application uses plant essential oil as the main functional ingredient for mosquito repellency, which has the advantages of being natural, green, mild, safe, without side effects, and without pollution to the environment. The essential oil composition of the present application has the effects of antibacterial, antifungal and antiviral, and can prevent the risk of infection caused by mosquito bites when applied on the skin, and can also relieve skin redness and itching and help the skin to heal as soon as possible. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 : Effective protection time of the sample to be tested. DETAILED DESCRIPTION

[0020] The present application provides a kind of essential oil composition, including the following weight parts of components: 30-50 parts of fructus alpiniae oxyphyllae essential oil, 20-40 parts of Citrus reticulata Blanco essential oil, 15-30 parts of coriander seed essential oil;Preferably, including the following weight parts of components: 35-45 parts of fructus alpiniae oxyphyllae essential oil, 25-30 parts of Citrus reticulata Blanco essential oil, 20-25 parts of coriander seed essential oil;More preferably, including the following weight parts of components: 40 parts of fructus alpiniae oxyphyllae essential oil, 30 parts of Citrus reticulata Blanco essential oil, 20 parts of coriander seed essential oil.

[0021] The essential oil composition provided by the present application uses natural plant essential oil, which is rich in various terpenes such as auraptene, limonene, citronellal and linalool, and the active ingredients in the essential oil have a synergistic effect on mosquito repellent and can prevent infection caused by mosquito bites, relieve skin redness and itching, and promote skin healing.

[0022] In the present application, fructus alpiniae oxyphyllae is derived from the dried mature fruits of Alpinia oxyphylla Miq. of Zingiberaceae, which is a native medicinal material in Hainan and is known as one of the "four large southern medicines" in China. Fructus alpiniae oxyphyllae is rich in essential oil, and the essential oil is rich in high content of auraptene.

[0023] Citrus reticulata Blanco cv. Manau Gan belongs to the genus Citrus of Rutaceae. The essential oil content in the peel of Citrus reticulata Blanco cv. Manau Gan is relatively high, about 2.5%, and the content of D-limonene accounts for more than 80%. D-limonene has strong penetration performance. Once insects come into contact with the pesticide, the wax waterproof protective layer covering the surface of the insect is destroyed, a large amount of internal excretion liquid is produced, the stomata are blocked, the ability of the insect to obtain sufficient oxygen is disturbed, the insect is knocked down quickly, suffocated, and presents a clear state of dehydration.

[0024] Coriandrum sativum L. is an annual or biennial herbaceous plant of the Apiaceae Coriandrum seed genus. It is not only a delicious vegetable, but also a common traditional Chinese medicinal material. The content of linalool in coriander seed essential oil can reach about 80%. Linalool can cause strong stimulation to the olfactory system of mosquitoes, thereby playing a role in mosquito repellent.

[0025] The above essential oils in the present application are commercially available products well known to those skilled in the art.

[0026] In the present application, it is found that the essential oils of fructus alpiniae oxyphyllae, Citrus reticulata Blanco and coriander seed are compounded in a specific ratio, and the various active ingredients in the essential oils show a significant synergistic effect in mosquito repellent, which can significantly prolong the mosquito repellent time.

[0027] The present application provides a mosquito repellent product comprising the essential oil composition.

[0028] In the present application, the weight percentage of the essential oil composition in the mosquito repellent product is 5-20%, preferably 8-16%.

[0029] In the present application, the mosquito repellent product further comprises a surfactant, which can be selected from any one or several of Tween, hydrogenated castor oil and alkyl glucoside.

[0030] In the present application, the mosquito repellent product further comprises an organic solvent, which is de-aldehyde ethanol.

[0031] In the present application, the mosquito repellent product can be prepared into different dosage forms as needed, and further comprises acceptable adjuvants, which are added to prepare different dosage forms, including aqueous, emulsion and ointment.

[0032] The present application also provides a preparation method of the mosquito repellent product, which comprises weighing the essential oil of Japanese arborvitae, essential oil of lion head orange and essential oil of coriander seed, mixing and stirring uniformly, adding a surfactant and stirring uniformly, adding an organic solvent, and ultrasonic treatment to obtain the mosquito repellent product.

[0033] In the present application, the ultrasonic treatment temperature is 20-50℃, the treatment time is 10-30min, and the ultrasonic power is 200-1000W; preferably, the ultrasonic treatment temperature is 30-40℃, the treatment time is 15-25min, and the ultrasonic power is 400-800W.

[0034] The present application also provides the application of the essential oil composition or the mosquito repellent product in mosquito repellent.

[0035] In the present application, the essential oil composition or mosquito repellent product is used every 5-7h, preferably every 5.5-6.5h. The present application can effectively repel mosquitoes and prolong the mosquito repellent time.

[0036] As an implementable way, the mosquito repellent product of the present application can be directly used on bare skin or the site after mosquito bites when used.

[0037] Unless otherwise specified, the reagents involved in the present application are all commercially available products, which can be obtained through stable commercial channels.

[0038] The technical solutions provided by the present application will be described in detail below in combination with examples, but they should not be understood as limiting the scope of protection of the present application.

[0039] Examples 1-5

[0040] Examples 1-5 respectively provide an essential oil composition

[0041] The proportions of the components of the essential oil compositions of Examples 1-5 are shown in Table 1.

[0042] Table 1 Components of the essential oil compositions of Examples 1-5 (in parts by weight)

[0043]

[0044] Comparative Example 1

[0045] Only contains single essential oil of Alpinia Oxyphylla.

[0046] Comparative Example 2

[0047] Only contains single essential oil of Citrus Aurantium.

[0048] Comparative Example 3

[0049] Only contains single essential oil of Coriandrum Sativum.

[0050] Comparative Example 4

[0051] An essential oil composition comprising: essential oil of Alpinia Oxyphylla 40 parts, essential oil of Citrus Aurantium 30 parts.

[0052] Comparative Example 5

[0053] An essential oil composition comprising: essential oil of Alpinia Oxyphylla 40 parts, essential oil of Coriandrum Sativum 20 parts.

[0054] Comparative Example 6

[0055] An essential oil composition comprising: essential oil of Citrus Aurantium 30 parts, essential oil of Coriandrum Sativum 20 parts.

[0056] Examples 6-12

[0057] Examples 6-12 each provide a mosquito repellent product comprising the essential oil composition of Examples 1-5 respectively

[0058] The proportions of the components of the mosquito repellent products of Examples 6-12 are shown in Table 2.

[0059] Table 2 Components of the mosquito repellent products of Examples 6-12 (in percentage by weight %)

[0060]

[0061] Preparation method: essential oil of Alpinia Oxyphylla, essential oil of Citrus Aurantium and essential oil of Coriandrum Sativum are weighed according to the proportion, mixed and stirred uniformly, Tween-20 is added and stirred uniformly, de-aldehyde ethanol is added, ultrasonic treatment is carried out at 40℃ for 20min, the ultrasonic power is 600W, and a mosquito repellent liquid is obtained.

[0062] Comparative Examples 7-12

[0063] Comparative Examples 7-12 each provide a mosquito repellent product comprising the essential oil composition of Comparative Examples 1-6 respectively

[0064] The components of the mosquito repellent products of Comparative Examples 7-12 are shown in Table 3.

[0065] Table 3 Components of mosquito repellent products of Comparative Examples 7-12 (% by weight)

[0066]

[0067]

[0068] The method of Examples 6-12 was followed.

[0069] Example 13

[0070] This example compares the effective protection time of different mosquito repellent products

[0071] Human mosquito repellency test

[0072] Four test subjects with acceptable biting force (half male and half female, and not drinking tea, coffee or alcohol, and not using products containing fragrances before and during the test) were selected, and a 5 cm x 5 cm area of skin was drawn on the back of each hand. One hand was uniformly coated with the mosquito repellent product under test at a dose of 1.5 μL / cm 2 , and a 4 cm x 4 cm area of skin was exposed, with the rest of the area being tightly covered. The other hand was left as a blank control. The mosquito repellent product was left on for 2 h, and the hands were then inserted into a mosquito cage with acceptable biting force for 2 min, and the presence or absence of mosquitoes landing and sucking blood was observed. The test was then repeated at 1 h intervals, and the mosquito repellent product was considered to have failed as soon as one mosquito landed and sucked blood. The effective protection time (h) of the mosquito repellent product was recorded, and the results are shown in Figure 1 Table 4. The control hand was first tested each time, and the test mosquitoes with acceptable biting force were used for the test, and mosquitoes with unacceptable biting force were replaced with mosquitoes with acceptable biting force.

[0073] Calculation of effective protection time: the average of the effective protection times of the test subjects was taken.

[0074] Table 4 Effective protection time of different mosquito repellent products

[0075]

[0076]

[0077] The results show that the mosquito repellent product containing the essential oil composition of the present application can effectively protect for more than 5.5 hours. According to the comparison of the results of the comparative examples and the examples, it can be seen that the mosquito repellent product provided by the present application has significantly better effective protection time than the comparative examples, indicating that the essential oil of Yizhi, essential oil of Shitougan, and essential oil of Cumin seed are compounded in a certain proportion, and the rich citraurapten, D-limonene, and linalool mosquito-repelling functional components therein exhibit significant synergistic effect, greatly improving the mosquito-repelling effect and prolonging the effective protection time of the mosquito repellent product.

[0078] Example 14

[0079] The present embodiment provides a mosquito repellent emulsion

[0080] 10.0 g of the essential oil composition in Example 3, 5.0 g of polyoxyethylene glycol ether-40 hydrogenated castor oil, and 1.0 g of PEG-400 are mixed uniformly to obtain component A; 0.2 g of carbomer, 1.0 g of glycerol, and 82.8 g of deionized water are mixed, heated and stirred in a 70°C water bath until the carbomer is completely dissolved to obtain component B; cooled to 40-50°C, component A is slowly added to component B, and homogenized and emulsified to obtain a mosquito repellent emulsion.

[0081] Example 15

[0082] The present embodiment provides a mosquito repellent paste

[0083] 5.0 g of vaseline, 28.0 g of paraffin, and 2.0 g of beeswax are weighed, melted and mixed uniformly in an 80°C water bath, then 55.0 g of olive oil and 10.0 g of the essential oil composition in Example 3 are added, mixed and stirred uniformly, filled, and cooled and shaped to obtain a mosquito repellent paste.

[0084] The above only describes the preferred embodiments of the present application, and it should be noted that those skilled in the art can make several improvements and refinements without departing from the principles of the present application, and these improvements and refinements should also be considered within the protection scope of the present application.

Claims

1. A mosquito repellent product, characterized by, The mosquito repellent product is composed of an essential oil composition, a surfactant and an organic solvent, the essential oil composition is composed of the following components in parts by weight: 40 parts of Chinese aniseed essential oil, 30 parts of bergamot essential oil and 20 parts of coriander seed essential oil; the weight percentage of the essential oil composition in the mosquito repellent product is 5-20%; The surfactant includes any one or several of tween, hydrogenated castor oil and alkyl glucoside; the organic solvent is de-aldehyde ethanol; The preparation method of the mosquito repellent product comprises the following steps: The Chinese aniseed essential oil, the bergamot essential oil and the coriander seed essential oil are weighed in proportion, mixed and stirred uniformly, the surfactant is added and stirred uniformly, the organic solvent is added, ultrasonic treatment is conducted, and the mosquito repellent product is obtained.

2. The method of making the mosquito repellent product of claim 1, wherein, The method comprises the following steps: The Chinese aniseed essential oil, the bergamot essential oil and the coriander seed essential oil are weighed in proportion, mixed and stirred uniformly, the surfactant is added and stirred uniformly, the organic solvent is added, ultrasonic treatment is conducted, and the mosquito repellent product is obtained.

3. The method of claim 2, wherein the mosquito repellent product is prepared by mixing the mosquito repellent agent and the carrier in a ratio of 1 : 1 to 1 :

10. The ultrasonic treatment temperature is 20-50℃, the treatment time is 10-30 min, and the ultrasonic power is 200-1000 W.

4. The mosquito repellent product of claim 1 is used for repelling mosquitoes.

5. Use according to claim 4, characterized in that, The mosquito repellent product is used every 5-7 h.

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