A dual-temperature zone continuous microreactor suitable for two-step reactions

Abstract

This invention relates to the field of microreactors and discloses a dual-temperature zone continuous microreactor suitable for two-step reactions. It includes a pre-cooling / heating channel plate, a mixing reaction channel plate, and several heat exchange channel plates disposed on both sides of the pre-cooling / heating channel plate and the mixing reaction channel plate, each equipped with a dual-temperature zone. On one hand, the addition of the pre-cooling / heating channel plate in the microreactor facilitates sufficient heat exchange of the reactants before the reaction. On the other hand, the optimized design of the pre-cooling / heating channel plate, the mixing reaction channel plate, and the heat exchange channel plates improves the integration of the microreactor. Combining these two improvements, the microreactor of this invention can achieve continuous production of two-step reactions under different temperature conditions, with good heat exchange performance, reducing the impact of unstable, difficult-to-handle, or hazardous intermediate products.

Description

Technical Field

[0001] This invention relates to the field of microreactors, and more particularly to a dual-temperature zone continuous microreactor suitable for two-step reactions. Background Technology

[0002] A microchannel reactor is a three-dimensional structural element used to carry out chemical reactions, fabricated on a solid matrix using specialized microfabrication techniques. Microchannel reactors typically contain small channel sizes and a high variety of channels through which fluids flow and where desired reactions are required to occur. Possessing a very large specific surface area, microchannel reactors offer significantly better heat and mass transfer capabilities compared to reaction vessels.

[0003] In the field of microreactor systems, the development of microreactors is moving towards industrialized continuous production. For specific reactions, specific reactors need to be designed according to process requirements, which should be integrated, convenient, and safer. The preparation of general compounds usually requires multiple specific reactions. In these reactions, factors such as unstable intermediate products, difficult post-processing, or flammability and explosiveness often arise, which greatly restricts pilot-scale and industrial-scale production.

[0004] Patent 201711226642.3 discloses a method for synthesizing 4-amino-3-chlorophenol using a multi-temperature zone continuous flow microchannel reactor. The microchannel reactor includes one or more preheating modules and one or more reaction module groups, achieving preheating and multi-temperature zone control through series or parallel connection of individual module reactors. However, this method has low integration, and the piping connections between modules inevitably lead to heat loss and increase the risk of blockage and leakage.

[0005] Patent 200610088398.4 discloses a composite heat exchange reactor, which integrates a microchemical reaction channel and a multi-temperature zone heat exchange channel on a substrate. However, this design is not suitable for scale-up and industrialization. The heat exchange interfaces are scattered, which is not conducive to integration; the heat exchange channels are insufficient, and the ideal heat exchange flux is 3-10 times the fluid flux to achieve a good heat exchange effect; moreover, the reactor does not have a pre-cooling / heating channel. If the reaction is a low-temperature reaction with a fast reaction rate and a large amount of heat release, there is simply not enough time for heat exchange. Summary of the Invention

[0006] To address the technical problems of low integration and poor heat exchange in existing multi-temperature zone microreactors, this invention provides a dual-temperature zone continuous microreactor suitable for two-step reactions. On one hand, this invention adds a pre-cooling / heating channel plate to the microreactor, which facilitates sufficient heat exchange of the reactants before the reaction. On the other hand, this invention improves the integration of the microreactor through optimized design of the pre-cooling / heating channel plate, the mixing reaction channel plate, and the heat exchange channel plate. Combining these two improvements, the microreactor of this invention can achieve continuous production of two-step reactions under different temperature conditions, with good heat exchange performance, reducing the impact of unstable, difficult-to-handle, or hazardous intermediate products.

[0007] The specific technical solution of this invention is: a dual-temperature zone continuous microreactor suitable for two-step reactions, comprising stacked interconnected layers:

[0008] Precooling / heating channel plate: One side surface of the precooling / heating channel plate is divided into temperature zone 1 and temperature zone 2; the surface of temperature zone 1 of the precooling / heating channel plate is provided with a precooling / heating channel for material A, a precooling / heating channel for material B, a heat exchange liquid outlet cavity for temperature zone 1, and a heat exchange liquid auxiliary cavity for temperature zone 1; the surface of temperature zone 2 of the precooling / heating channel plate is provided with a precooling / heating channel for material C, a heat exchange liquid outlet cavity for temperature zone 2, and a heat exchange liquid auxiliary cavity for temperature zone 2.

[0009] Mixing reaction channel plate: The surface of the mixing reaction channel plate is provided with AB material reaction channel and CD material reaction channel; the inlet of the AB material reaction channel is connected to the outlet of the A material precooling / heating channel and the outlet of the B material precooling / heating channel, respectively; the inlet of the CD material reaction channel is connected to the outlet of the AB material reaction channel and the outlet of the C material precooling / heating channel, respectively; one side surface of the mixing reaction channel plate is divided into temperature zone one and temperature zone two; the surface of temperature zone one of the mixing reaction channel plate is provided with a temperature zone one heat exchange liquid inlet cavity and a temperature zone one heat exchange liquid auxiliary cavity, and the surface of temperature zone two of the mixing reaction channel plate is provided with a temperature zone two heat exchange liquid inlet cavity and a temperature zone two heat exchange liquid auxiliary cavity.

[0010] Several heat exchange channel plates: The heat exchange channel plates are disposed on both sides of the precooling / heating channel plate and the mixing reaction channel plate. One side surface of the heat exchange channel plate is divided into temperature zone 1 and temperature zone 2. Temperature zone 1 and temperature zone 2 of the heat exchange channel plate are respectively provided with temperature zone 1 heat exchange channel and temperature zone 2 heat exchange channel. The temperature zone 1 heat exchange liquid inlet cavity, temperature zone 1 heat exchange liquid auxiliary cavity, temperature zone 1 heat exchange channel and temperature zone 1 heat exchange liquid outlet cavity are connected to form a temperature zone 1 heat exchange liquid circulation channel. The temperature zone 2 heat exchange liquid inlet cavity, temperature zone 2 heat exchange liquid auxiliary cavity, temperature zone 2 heat exchange channel and temperature zone 2 heat exchange liquid outlet cavity are connected to form a temperature zone 2 heat exchange liquid circulation channel.

[0011] The dual-temperature zone continuous microreactor of the present invention is suitable for two-step reactions, and its features are as follows:

[0012] (1) The present invention adds a precooling / heating channel plate to the microreactor, which is beneficial to the full heat exchange of the reactants before the reaction. Especially for some low-temperature reactions, it can provide sufficient heat exchange time (the reaction rate of low-temperature reactions is generally faster, so more sufficient heat exchange time is required).

[0013] (2) This invention improves the integration of the microreactor through optimized design of the precooling / heating channel plate, the mixing reaction channel plate, and the heat exchange channel plate. The working principle of the dual-temperature zone continuous microreactor of this invention is as follows: First, two heat exchange liquids at different temperatures enter the microreactor through the inlet cavity of the temperature zone 1 / 2 heat exchange liquid of the mixing reaction channel plate, and diffuse through the auxiliary cavity of the temperature zone 1 / 2 heat exchange liquid throughout the entire microreactor to the temperature zones 1 / 2 of each heat exchange channel plate, the mixing reaction channel plate, and the precooling / heating channel plate, and finally flow out through the outlet cavity of the temperature zone 1 / 2 heat exchange liquid of the precooling / heating channel plate. Under the condition of heat exchange liquid circulation, the reaction raw materials A / B / C are introduced through the A material precooling / heating channel, the B material precooling / heating channel, and the C material precooling / heating channel of the precooling / heating channel plate, respectively. Among them, A material and B material undergo preliminary heat exchange with the heat exchange liquid in temperature zone 1, and C material undergoes preliminary heat exchange with the heat exchange liquid in temperature zone 2. After initial heat exchange, materials A, B, and C are respectively introduced into the mixing reaction channel plate. Materials A and B are mixed and further heat exchanged in the AB material reaction channel to generate material D. Material D is further mixed and heat exchanged with material C in the CD material reaction channel to generate product E. Finally, product E is discharged from the outlet of the CD material reaction channel and collected.

[0014] In summary, this invention improves integration by adding a pre-cooling / heating channel plate and rationally arranging the internal structure of the microreactor, forming two heat exchange zones (temperature zone one and temperature zone two). This enables continuous production of two-step reactions under different temperature conditions, resulting in good heat exchange performance and reducing the impact of unstable, difficult-to-handle, or dangerous intermediate products.

[0015] Preferably, the distribution of the AB material reaction channels and CD material reaction channels on the mixing reaction channel plate includes two parallel arrangements:

[0016] Option 1: The AB material reaction channel is located in temperature zone 1; the CD material reaction channel is located in temperature zone 2.

[0017] Option 2: Under operating conditions, the temperature in temperature zone 1 is lower than that in temperature zone 2; the AB material reaction channel passes through temperature zone 1 and temperature zone 2 sequentially; the CD material reaction channel is located in temperature zone 1.

[0018] This invention designs two different mixing reaction channel plates. Among them:

[0019] The working principle of Scheme 1 is as follows: After materials A and B enter the mixing reaction channel plate, they are mixed in the AB material reaction channel, exchange heat with the heat exchange liquid in temperature zone 1, and generate material D. Material D and material C are mixed in the CD material reaction channel, exchange heat with the heat exchange liquid in temperature zone 2, and generate product E.

[0020] The advantage of Option 1 lies in its design of placing the two-step reactions at different temperatures on the same reaction surface, reducing energy loss and connection risks associated with connecting different reactors. In some reactions, the first step is a lower-temperature reaction, and the second step is a higher-temperature reaction. Furthermore, if the first step reaction takes too long, solids will gradually form, requiring timely processing or incorporation into the next reaction. In this case, this design effectively solves the problem of unstable first-step products, eliminates redundant pipeline channels, and virtually eliminates the risk of blockage after process optimization.

[0021] In Scheme 2, the temperature in Zone 2 is higher than that in Zone 1. Its working principle is as follows: After materials A and B enter the mixing reaction channel plate, they are mixed in the AB material reaction channel. They first exchange heat with the heat exchange liquid in Zone 1, and then exchange heat further with the heat exchange liquid in Zone 2 to accelerate the reaction and generate material D. Then material D flows back to Zone 1 and mixes with material C, exchanges heat with the heat exchange liquid in Zone 1 and reacts to generate product E.

[0022] The advantage of Option 2 lies in the following: In some reactions, once initiated, the reaction proceeds rapidly and releases a large amount of heat, leading to localized overheating and numerous side reactions. Furthermore, in a microreactor, mixing efficiency largely determines the reaction rate and purity. When materials A and B enter the mixing reaction channel plate, they are not yet fully mixed. If the temperature is high and the reaction is rapid, side reactions and impurities are easily generated. Therefore, temperature zone one is designed to be at a lower temperature. After materials A and B pass through the reaction channel in temperature zone one, they achieve a better degree of mixing. At this point, the temperature needs to be increased to accelerate the reaction rate; therefore, temperature zone two is designed to be at a higher temperature. Controlling the mixing and reaction rates through a series of methods is to better control the reaction temperature when the reaction is violently exothermic, preventing the exothermic reaction from accumulating at a single point in the reactor, leading to temperature runaway and side reactions. The mixing reactions of materials D and C are both carried out at the lower temperature in temperature zone one.

[0023] Preferably, one side surface of the precooling / heating channel plate, the mixing reaction channel plate, and the heat exchange channel plate is divided into a temperature zone one and a temperature zone two by a vacuum cavity.

[0024] Since there is a certain temperature difference between temperature zone 1 and temperature zone 2, in order to avoid heat transfer, the present invention uses a vacuum cavity to separate temperature zone 1 and temperature zone 2. After evacuating the vacuum cavity, heat transfer can be effectively reduced.

[0025] Preferably, in the precooling / heating channel plate, the inlets of the precooling / heating channels for material A, material B, and material C, as well as the heat exchange liquid outlet cavities for temperature zone one and temperature zone two, extend to the sides of the precooling / heating channel plate.

[0026] Preferably, in the mixing reaction channel plate, the outlet of the CD material reaction channel, the inlet cavity of the heat exchange liquid in temperature zone one, and the inlet cavity of the heat exchange liquid in temperature zone two extend to the side of the mixing reaction channel plate.

[0027] Preferably, the precooling / heating channels for materials A, B, and C, the reaction channel for materials AB, and the reaction channel for materials CD are curved, and several S-shaped turbulence blocks are arranged in the flow direction. The heat exchange channels in temperature zone one and temperature zone two are curved, and several staggered flow-slowing baffles are provided in the flow direction.

[0028] Designing the flow channels of the precooling / heating channel plate, mixing reaction channel plate, and heat exchange channel plate as curved can increase heat exchange or reaction time. Designing turbulence blocks or flow-slowing baffles on the flow channels can further improve the material mixing effect or delay the residence time.

[0029] Preferably, temperature measurement channels that communicate with the outside are provided in temperature zone 1 and temperature zone 2 of the mixing reaction channel plate.

[0030] The temperature measurement channel is designed to facilitate the real-time monitoring of the temperatures in temperature zones 1 and 2, which is beneficial for controlling the reaction.

[0031] Preferably, there are four heat exchange channel plates, which are attached to the two sides of the precooling / heating channel plate and the mixing reaction channel plate in pairs; a partition is sandwiched between the two innermost heat exchange channel plates; the surface of the partition is divided into temperature zone one and temperature zone two by a vacuum cavity; the surface of temperature zone one and temperature zone two of the partition is provided with heat exchange liquid auxiliary passage cavity for temperature zone one and temperature zone two, respectively.

[0032] A heat exchange channel plate can be installed on each side of the precooling / heating channel plate and the mixing reaction channel plate to improve the heat exchange effect.

[0033] Preferably, the dual-temperature zone continuous microreactor also includes two cover plates stacked on the outside of the two outermost heat exchange channel plates.

[0034] Compared with the prior art, the beneficial effects of the present invention are:

[0035] (1) The present invention adds a precooling / heating channel plate in the microreactor, which is beneficial to the full heat exchange of the reactants before the reaction.

[0036] (2) By optimizing the design of the precooling / heating channel plate, the mixing reaction channel plate and the heat exchange channel plate, the present invention improves the integration of the microreactor, enabling continuous production of two-step reactions at different temperature conditions. The heat exchange effect is good, which can reduce the influence of factors such as unstable intermediate products, difficult handling or danger.

[0037] (3) The present invention designs a mixed reaction channel plate with two different flow channel layouts, which can be applied to different types of two-step synthesis reactions. Attached Figure Description

[0038] Figure 1 This is a schematic diagram showing the split of the dual-temperature zone continuous microreactor of Embodiment 1 of the present invention;

[0039] Figure 2 This is a plan view of each plate in the dual-temperature zone continuous microreactor of Embodiment 1 of the present invention;

[0040] Figure 3 This is a schematic diagram of the overall appearance of the dual-temperature zone continuous microreactor of Embodiment 1 of the present invention;

[0041] Figure 4 This is a plan view of the precooling / heating channel plate in the dual-temperature zone continuous microreactor of Embodiment 1 of the present invention;

[0042] Figure 5 This is a plan view of the mixing reaction channel plate in the dual-temperature zone continuous microreactor of Embodiment 1 of the present invention;

[0043] Figure 6 This is a plan view of one of the heat exchange channel plates in the dual-temperature zone continuous microreactor of Embodiment 1 of the present invention;

[0044] Figure 7 This is a plan view of each plate in the dual-temperature zone continuous microreactor of Embodiment 2 of the present invention;

[0045] Figure 8 This is a plan view of the mixing reaction channel plate in the dual-temperature zone continuous microreactor of Embodiment 2 of the present invention.

[0046] The attached diagram is labeled as follows: Precooling / heating channel plate 1, Precooling / heating channel 11 for material A, Precooling / heating channel 12 for material B, Precooling / heating channel 13 for material C, Mixing reaction channel plate 2, Reaction channel 21 for materials AB, Reaction channel 22 for materials CD, Heat exchange channel plate 3, Heat exchange channel 31 for temperature zone 1, Heat exchange channel 32 for temperature zone 2, Vacuum chamber 4, Turbulence block 5, Flow slowing baffle 6, Temperature measuring channel 7, Baffle 8, Cover plate 9, Temperature zone 1 a, Temperature zone 2 b, Heat exchange liquid outlet cavity for temperature zone 1 c, Heat exchange liquid auxiliary cavity for temperature zone 1 d, Heat exchange liquid outlet cavity for temperature zone 2 e, Heat exchange liquid auxiliary cavity for temperature zone 2 f, Heat exchange liquid inlet cavity for temperature zone 1 g, Heat exchange liquid inlet cavity for temperature zone 2 h. Detailed Implementation

[0047] The present invention will be further described below with reference to embodiments.

[0048] General Implementation Examples

[0049] A dual-temperature zone continuous microreactor suitable for two-step reactions, such as Figure 1-3 as well as Figure 7 As shown, the system comprises the following layered components stacked sequentially: cover plate 9, heat exchange channel plate 3, precooling / heating channel plate 1, heat exchange channel plate 3, partition plate 8, heat exchange channel plate 3, mixing reaction channel plate 2, heat exchange channel plate 3, and cover plate 9. Wherein:

[0050] One side surface of the precooling / heating channel plate, the mixing reaction channel plate, the heat exchange channel plate, and the partition is divided into temperature zone a and temperature zone b by the vacuum cavity 4.

[0051] like Figure 4 As shown, in the precooling / heating channel plate 1: the surface of the temperature zone one of the precooling / heating channel plate is provided with a precooling / heating channel 11 for material A, a precooling / heating channel 12 for material B, a heat exchange liquid outlet cavity c for temperature zone one, and a heat exchange liquid auxiliary cavity d for temperature zone one. Specifically, the surface of the temperature zone two of the precooling / heating channel plate is provided with a precooling / heating channel 13 for material C, a heat exchange liquid outlet cavity e for temperature zone two, and a heat exchange liquid auxiliary cavity f for temperature zone two. The inlets of the precooling / heating channels for materials A, B, and C, as well as the heat exchange liquid outlet cavities for temperature zone one and temperature zone two, extend to the sides of the precooling / heating channel plate. The precooling / heating channels for materials A, B, and C are all curved, and a large number of S-shaped turbulence blocks 5 are arranged in the flow direction of the channels.

[0052] like Figure 5 or Figure 8As shown, in the mixing reaction channel plate 2: the surface of the mixing reaction channel plate is provided with AB material reaction channel 21 and CD material reaction channel 22. The inlets of the AB material reaction channels are connected to the outlets of the A material precooling / heating channel and the B material precooling / heating channel, respectively; the inlets of the CD material reaction channels are connected to the outlets of the AB material reaction channels and the C material precooling / heating channel, respectively. The surface of the first temperature zone of the mixing reaction channel plate is provided with a first temperature zone heat exchange liquid inlet cavity g and a first temperature zone heat exchange liquid auxiliary cavity d, and the surface of the second temperature zone of the mixing reaction channel plate is provided with a second temperature zone heat exchange liquid inlet cavity h and a second temperature zone heat exchange liquid auxiliary cavity f. The outlet of the CD material reaction channel, the first temperature zone heat exchange liquid inlet cavity, and the second temperature zone heat exchange liquid inlet cavity extend to the side of the mixing reaction channel plate. Both the AB material reaction channel and the CD material reaction channel are curved, and a large number of S-shaped turbulence blocks 5 are arranged in the flow direction of the channels. In addition, temperature measuring channels 7, which are connected to the outside, are provided in temperature zone 1 and temperature zone 2 of the mixing reaction channel plate for temperature measurement.

[0053] Furthermore, the distribution of the AB material reaction channels and CD material reaction channels on the mixing reaction channel plate includes two parallel schemes:

[0054] Option 1: As Figure 5 As shown, the reaction channel for material AB is located in temperature zone one; the reaction channel for material CD is located in temperature zone two.

[0055] Option 2: Figure 8 As shown, in operation, the temperature of temperature zone one is lower than that of temperature zone two; the AB material reaction channel flows through temperature zone one and temperature zone two in sequence; the CD material reaction channel is located in temperature zone one.

[0056] like Figure 6 As shown, in the heat exchange channel plate 3, the surfaces of temperature zone one and temperature zone two are respectively provided with temperature zone one heat exchange channel 31 and temperature zone two heat exchange channel 32. The temperature zone one heat exchange channel and temperature zone two heat exchange channel are curved, and a large number of flow-slowing baffles 6 are staggered according to the channel flow direction. The temperature zone one heat exchange liquid inlet cavity, temperature zone one heat exchange liquid auxiliary cavity, temperature zone one heat exchange channel and temperature zone one heat exchange liquid outlet cavity are connected to form the temperature zone one heat exchange liquid circulation channel; similarly, the temperature zone two heat exchange liquid inlet cavity, temperature zone two heat exchange liquid auxiliary cavity, temperature zone two heat exchange channel and temperature zone two heat exchange liquid outlet cavity are connected to form the temperature zone two heat exchange liquid circulation channel.

[0057] like Figure 1 , Figure 2 or Figure 7 As shown, in the partition 8: the surfaces of temperature zone 1 and temperature zone 2 of the partition are respectively provided with heat exchange liquid auxiliary passage d in temperature zone 1 and heat exchange liquid auxiliary passage f in temperature zone 2.

[0058] Furthermore, the aforementioned boards are tightly bonded together using vacuum diffusion welding. The board thickness is on the order of millimeters, while the channel width and depth are on the order of micrometers or millimeters. Each board can be processed using techniques such as CNC milling, chemical etching, electrical discharge machining, and laser ablation. The board materials can be metals (316L, Hastelloy, titanium and titanium alloys, etc.), or silicon carbide, glass, etc.

[0059] Example 1 (The mixing reaction channel plate uses Scheme 1)

[0060] A dual-temperature zone continuous microreactor suitable for two-step reactions, such as Figure 1-3 As shown, the system comprises the following layered components stacked sequentially: cover plate 9, heat exchange channel plate 3, precooling / heating channel plate 1, heat exchange channel plate 3, partition plate 8, heat exchange channel plate 3, mixing reaction channel plate 2, heat exchange channel plate 3, and cover plate 9. Wherein:

[0061] One side surface of the precooling / heating channel plate, the mixing reaction channel plate, the heat exchange channel plate, and the partition are all divided into temperature zone a and temperature zone b by the vacuum cavity 4.

[0062] like Figure 4 As shown, in the precooling / heating channel plate 1: the surface of the first temperature zone of the precooling / heating channel plate is provided with a precooling / heating channel 11 for material A, a precooling / heating channel 12 for material B, a heat exchange liquid outlet cavity c for the first temperature zone, and a heat exchange liquid auxiliary cavity d for the first temperature zone; the surface of the second temperature zone of the precooling / heating channel plate is provided with a precooling / heating channel 13 for material C, a heat exchange liquid outlet cavity e for the second temperature zone, and a heat exchange liquid auxiliary cavity f for the second temperature zone. The inlets of the precooling / heating channels for materials A, B, and C, as well as the heat exchange liquid outlet cavities for the first and second temperature zones, extend to the sides of the precooling / heating channel plate. The precooling / heating channels for materials A, B, and C are curved, and a large number of S-shaped turbulence blocks 5 are arranged in the flow direction of the channels.

[0063] like Figure 5 or Figure 8As shown, in the mixing reaction channel plate 2: the surface of the mixing reaction channel plate is provided with AB material reaction channel 21 (located in temperature zone 1) and CD material reaction channel 22 (located in temperature zone 2); the inlets of the AB material reaction channels are respectively connected to the outlets of the A material precooling / heating channel and the B material precooling / heating channel (each plate has a through hole at the corresponding position); the inlets of the CD material reaction channels are respectively connected to the outlets of the AB material reaction channels and the C material precooling / heating channel (each plate has a through hole at the corresponding position). The surface of temperature zone 1 of the mixing reaction channel plate is provided with a temperature zone 1 heat exchange liquid inlet cavity g and a temperature zone 1 heat exchange liquid auxiliary cavity d, and the surface of temperature zone 2 of the mixing reaction channel plate is provided with a temperature zone 2 heat exchange liquid inlet cavity h and a temperature zone 2 heat exchange liquid auxiliary cavity f. The outlet of the CD material reaction channel, the temperature zone 1 heat exchange liquid inlet cavity, and the temperature zone 2 heat exchange liquid inlet cavity extend to the side of the mixing reaction channel plate. Both the AB material reaction channel and the CD material reaction channel are curved, and a large number of S-shaped turbulence blocks 5 are arranged in the flow direction of the channels. In addition, temperature measuring channels 7 that communicate with the outside are respectively provided in temperature zone one and temperature zone two on the mixing reaction channel plate.

[0064] like Figure 6 As shown, in the heat exchange channel plate 3, the surfaces of temperature zone one and temperature zone two are respectively provided with temperature zone one heat exchange channel 31 and temperature zone two heat exchange channel 32. Both temperature zone one and temperature zone two heat exchange channels are curved, and a large number of flow-slowing baffles 6 are staggered according to the flow direction of the channels. The inlet cavity, auxiliary cavity, heat exchange channel and outlet cavity of the temperature zone one heat exchange liquid are connected to form the temperature zone one heat exchange liquid circulation channel; similarly, the inlet cavity, auxiliary cavity, heat exchange channel and outlet cavity of the temperature zone two heat exchange liquid are connected to form the temperature zone two heat exchange liquid circulation channel.

[0065] like Figure 1 , Figure 2 or Figure 7 As shown, in the partition 8: the surfaces of temperature zone 1 and temperature zone 2 of the partition are respectively provided with heat exchange liquid auxiliary passage d in temperature zone 1 and heat exchange liquid auxiliary passage f in temperature zone 2.

[0066] Furthermore, the aforementioned boards are tightly bonded together using vacuum diffusion welding, with a board thickness on the order of millimeters and channel width and depth on the order of micrometers. Each board can be machined using CNC milling technology. The material of each board can be metal (316L).

[0067] The working principle of the dual-temperature zone continuous microreactor in this embodiment is as follows: First, two heat exchange liquids at different temperatures enter the microreactor through the inlet cavities of the temperature zone 1 / 2 heat exchange liquid in the mixing reaction channel plate. These liquids diffuse through the auxiliary cavities of the temperature zone 1 / 2 heat exchange liquid throughout the entire microreactor to the temperature zones 1 / 2 of each heat exchange channel plate, the mixing reaction channel plate, and the pre-cooling / heating channel plate within the microreactor, and finally flow out through the outlet cavities of the temperature zone 1 / 2 heat exchange liquid in the pre-cooling / heating channel plate. With the heat exchange liquid circulating, the reaction raw materials A / B / C are introduced through the A material pre-cooling / heating channel, B material pre-cooling / heating channel, and C material pre-cooling / heating channel plate, respectively. Materials A and B undergo preliminary heat exchange with the heat exchange liquid in temperature zone 1, and material C undergoes preliminary heat exchange with the heat exchange liquid in temperature zone 2. After preliminary heat exchange, materials A / B / C are introduced into the mixing reaction channel plate. Specifically, after materials A and B enter the mixing reaction channel plate, they are mixed in the AB material reaction channel, exchange heat with the heat exchange liquid in temperature zone 1, and generate material D. Material D and material C are mixed in the CD material reaction channel, exchange heat with the heat exchange liquid in temperature zone 2, and generate product E. Finally, product E is discharged from the outlet of the CD material reaction channel and collected.

[0068] Example 2 (The mixing reaction channel plate uses Scheme 2)

[0069] The main difference between Example 2 and Example 1 is:

[0070] (1) The mixing reaction channel plate flow channel adopts Scheme 2: such as Figure 8 As shown, the AB material reaction channel flows through temperature zone 1 and temperature zone 2 successively; the CD material reaction channel is located in temperature zone 1.

[0071] (2) The positions of the through holes used for the flow of reactants and heat exchange fluid between the plates have been adapted.

[0072] The main difference between the working principle of the dual-temperature zone continuous microreactor in this embodiment and that in Embodiment 1 is that the temperature in temperature zone 2 is higher than that in temperature zone 1 in the mixing reaction channel plate. When materials A and B enter the mixing reaction channel plate, they are mixed in the AB material reaction channel. They first exchange heat with the heat exchange liquid in temperature zone 1, and then flow through temperature zone 2 for further heating with the heat exchange liquid in temperature zone 2 to accelerate the reaction and generate material D. Then material D flows back to temperature zone 1 and mixes with material C, exchanges heat with the heat exchange liquid in temperature zone 1 and reacts to generate product E.

[0073] Unless otherwise specified, the raw materials and equipment used in this invention are all commonly used in the field; unless otherwise specified, the methods used in this invention are all conventional methods in the field.

[0074] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Any simple modifications, alterations, and equivalent transformations made to the above embodiments based on the technical essence of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A dual-temperature zone continuous microreactor suitable for two-step reactions, characterized in that: Including stacked connections: Precooling / heating channel plate (1): One side surface of the precooling / heating channel plate is divided into temperature zone 1 (a) and temperature zone 2 (b); the surface of temperature zone 1 of the precooling / heating channel plate is provided with a precooling / heating channel for material A (11), a precooling / heating channel for material B (12), a heat exchange liquid outlet cavity (c) for temperature zone 1, and a heat exchange liquid auxiliary cavity (d) for temperature zone 1; the surface of temperature zone 2 of the precooling / heating channel plate is provided with a precooling / heating channel for material C (13), a heat exchange liquid outlet cavity (e) for temperature zone 2, and a heat exchange liquid auxiliary cavity (f) for temperature zone 2; Mixing reaction channel plate (2): The surface of the mixing reaction channel plate is provided with AB material reaction channel (21) and CD material reaction channel (22); the inlet of the AB material reaction channel is connected to the outlet of the A material precooling / heating channel and the outlet of the B material precooling / heating channel respectively; the inlet of the CD material reaction channel is connected to the outlet of the AB material reaction channel and the outlet of the C material precooling / heating channel respectively; one side surface of the mixing reaction channel plate is divided into temperature zone 1 (a) and temperature zone 2 (b); the surface of temperature zone 1 of the mixing reaction channel plate is provided with temperature zone 1 heat exchange liquid inlet cavity (g) and temperature zone 1 heat exchange liquid auxiliary cavity (d); the surface of temperature zone 2 of the mixing reaction channel plate is provided with temperature zone 2 heat exchange liquid inlet cavity (h) and temperature zone 2 heat exchange liquid auxiliary cavity (f); Several heat exchange channel plates (3): The heat exchange channel plates are located on both sides of the precooling / heating channel plate and the mixing reaction channel plate. One side surface of the heat exchange channel plate is divided into temperature zone 1 (a) and temperature zone 2 (b). Temperature zone 1 and temperature zone 2 of the heat exchange channel plate are respectively provided with temperature zone 1 heat exchange channel (31) and temperature zone 2 heat exchange channel (32). The temperature zone 1 heat exchange liquid inlet cavity, temperature zone 1 heat exchange liquid auxiliary cavity, temperature zone 1 heat exchange channel and temperature zone 1 heat exchange liquid outlet cavity are connected to form a temperature zone 1 heat exchange liquid circulation channel. The temperature zone 2 heat exchange liquid inlet cavity, temperature zone 2 heat exchange liquid auxiliary cavity, temperature zone 2 heat exchange channel and temperature zone 2 heat exchange liquid outlet cavity are connected to form a temperature zone 2 heat exchange liquid circulation channel.

2. The dual-temperature zone continuous microreactor as described in claim 1, characterized in that: The distribution of the AB material reaction channels and CD material reaction channels on the mixing reaction channel plate includes two parallel schemes: Option 1: The AB material reaction channel is located in temperature zone 1; the CD material reaction channel is located in temperature zone 2; Option 2: Under operating conditions, the temperature in temperature zone 1 is lower than that in temperature zone 2; the AB material reaction channel passes through temperature zone 1 and temperature zone 2 sequentially; the CD material reaction channel is located in temperature zone 1.

3. The dual-temperature zone continuous microreactor as described in claim 1 or 2, characterized in that: One side surface of the precooling / heating channel plate, the mixing reaction channel plate, and the heat exchange channel plate is divided into temperature zone one and temperature zone two by a vacuum cavity (4).

4. The dual-temperature zone continuous microreactor as described in claim 1 or 2, characterized in that: In the precooling / heating channel plate, the inlets of the precooling / heating channels for material A, material B, and material C, as well as the heat exchange liquid outlet cavities for temperature zone one and temperature zone two, extend to the sides of the precooling / heating channel plate.

5. The dual-temperature zone continuous microreactor as described in claim 1 or 2, characterized in that: In the mixing reaction channel plate, the outlet of the CD material reaction channel, the inlet cavity of the heat exchange liquid in temperature zone 1, and the inlet cavity of the heat exchange liquid in temperature zone 2 extend to the side of the mixing reaction channel plate.

6. The dual-temperature zone continuous microreactor as described in claim 1 or 2, characterized in that: The A material precooling / heating channel, B material precooling / heating channel, C material precooling / heating channel, AB material reaction channel and CD material reaction channel are curved, and several S-shaped turbulence blocks (5) are provided in the flow direction.

7. The dual-temperature zone continuous microreactor as described in claim 1 or 2, characterized in that: The heat exchange channels in temperature zone 1 and temperature zone 2 are curved, and several staggered slow-flow baffles (6) are provided in the flow direction.

8. The dual-temperature zone continuous microreactor as described in claim 1 or 2, characterized in that: Temperature measurement channels (7) that communicate with the outside are provided in temperature zone 1 and temperature zone 2 on the mixing reaction channel plate.

9. The dual-temperature zone continuous microreactor as described in claim 3, characterized in that: The number of heat exchange channel plates is 4, which are attached to the two sides of the precooling / heating channel plate and the mixing reaction channel plate in pairs; a partition (8) is sandwiched between the two innermost heat exchange channel plates; the surface of the partition is divided into temperature zone 1 (a) and temperature zone 2 (b) by a vacuum cavity (4); the surface of temperature zone 1 and temperature zone 2 of the partition is provided with a heat exchange liquid auxiliary passage (d) for temperature zone 1 and a heat exchange liquid auxiliary passage (f) for temperature zone 2, respectively.

10. The dual-temperature zone continuous microreactor as described in claim 1, characterized in that: It also includes two cover plates (9) stacked on the outside of the two outermost heat exchange channel plates.

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