An integrally formed three-dimensional degradable textile structural bone plate and a method of making the same

Abstract

The application discloses an integrally-formed three-dimensional degradable textile structure bone plate and a preparation method thereof. The preparation method is as follows: composite yarns composed of degradable glass fibers and other degradable materials are woven into a preformed body in the shape of a bone plate through three-dimensional weaving, three-dimensional knitting, three-dimensional needle knitting or three-dimensional angle interlocking, and in the weaving process, preformed holes are formed in the preformed body by adding a mold; and then the preformed body is sequentially subjected to heating and solidification and cooling treatment, so that the integrally-formed three-dimensional degradable textile structure bone plate is obtained. The finally-prepared three-dimensional degradable woven bone plate has better plasticity, can better adapt to the shape of a bone, improves the repair effect of the bone plate, has good flexibility and toughness, has better mechanical properties, has higher biocompatibility and degradability, and is suitable for the field of bone tissue repair.

Description

Technical Field

[0001] This invention belongs to the field of biodegradable materials and textile structures, and relates to an integrally molded three-dimensional biodegradable textile structural rib plate and its preparation method. Background Technology

[0002] Traditional bone repair materials typically include metal plates and screws, but these materials have several drawbacks, such as causing significant trauma, requiring secondary surgery for removal, and interfering with imaging examinations. Therefore, alternative materials are needed. Biodegradable materials are considered a promising option for bone repair due to their good biocompatibility, degradability, and plasticity. Biodegradable materials are usually made from biodegradable polymers such as polylactic acid, polyhydroxyalkanoates, and polycaprolactone, but these materials also have some limitations, such as poor plasticity, fragility, and rapid degradation.

[0003] To overcome these problems, researchers have proposed the concept of biodegradable textile structural bone plates. Biodegradable textile structural bone plates, made from materials such as polylactic acid fibers and biodegradable glass fibers, possess good flexibility and toughness, high biocompatibility, and biodegradability, making them a promising bone tissue repair material. Most existing biodegradable textile structural bone plates are formed using a two-dimensional lamination method, which presents the following problems:

[0004] (1) Poor overall mechanical strength and stability of the bone plate; On the one hand, two-dimensional lamination usually involves bonding multiple layers of materials together by pressure and heat treatment. However, the interfacial bonding strength between different materials may be low, leading to weaknesses and easy peeling or delamination. This reduces the overall mechanical strength and stability of the bone plate and limits its performance under stress. On the other hand, during the two-dimensional lamination process, interlayer pores, bubbles and defects are inevitably generated. These pores and defects may lead to stress concentration and failure points, reducing the mechanical strength and stability of the bone plate. In addition, in the two-dimensional lamination process, fibers can only be arranged on a plane, and it is impossible to achieve multi-directional fiber interlacing and optimized fiber distribution. This may lead to uneven fiber density and single fiber direction in some areas, resulting in local stress concentration and the formation of weaknesses.

[0005] (2) Bone plates cannot provide sufficient support for bone growth; bone plates prepared by two-dimensional lamination are usually planar structures that cannot provide sufficient three-dimensional support and connection, which may limit the interaction between the bone plate and the surrounding bone tissue and affect the ability of bone growth.

[0006] (3) The preparation is difficult; the process of preparing biodegradable textile structural plates by two-dimensional lamination is relatively complicated, requiring multiple steps and equipment, and the preparation process is cumbersome.

[0007] (4) It is easy to generate fuzz; on the one hand, the friction between material layers will cause the fibers or particles to misalign and move, thus forming fuzz; on the other hand, during the lamination process, the pressure is unevenly transmitted between material layers, with some areas receiving greater pressure and other areas receiving less pressure, which will cause incomplete contact and lead to the generation of fuzz; in addition, improper selection of process parameters: process parameters such as lamination temperature, pressure and duration have an impact on the formation of fuzz. If the parameters are not selected reasonably, the risk of fuzz generation will increase. Summary of the Invention

[0008] The purpose of this invention is to solve the problems existing in the prior art and to provide an integrally molded three-dimensional biodegradable textile structural rib plate and its preparation method.

[0009] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0010] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate involves weaving a composite yarn composed of biodegradable glass fiber and other biodegradable materials into a preform in the shape of a rib plate through three-dimensional braiding, three-dimensional machine weaving, three-dimensional knitting, or three-dimensional angular interlocking. During the weaving process, pre-formed holes are created in the preform by adding a mold. The preform is then subjected to heating, curing, and cooling treatments to obtain the one-piece molded three-dimensional biodegradable textile structural rib plate. The heating, curing, and cooling treatments are applied to the preform to solidify the composite material and enhance its mechanical properties and stability. Different pressures, times, and temperatures can be specifically designed according to actual needs, resulting in one-piece molded three-dimensional biodegradable woven rib plates with excellent performance, which have significant application value and promising prospects for promotion.

[0011] As a preferred technical solution:

[0012] As described above, in the preparation method of an integrally molded three-dimensional biodegradable textile structural rib plate, the mass content of biodegradable glass fiber in the composite yarn is 5%-95%. The degradation rate of the rib plate can be controlled by adjusting the ratio of biodegradable glass fiber and other biodegradable materials. The higher the content of biodegradable glass fiber, the slower the degradation rate; the higher the content of other biodegradable materials, the faster the degradation rate. Ideal mechanical properties can also be obtained by adjusting the ratio of biodegradable glass fiber and other biodegradable materials.

[0013] In the preparation method of the integrally molded three-dimensional biodegradable textile structural bone plate as described above, the other biodegradable materials are one or more of polylactic acid (PLA), polycaprolactone (PCL), polylactic-glycolic acid (PLGA), polyhydroxyalkanoate (PHA), and polyester (PGA).

[0014] For the fabrication of textile structural plates, using yarns made from a single biodegradable glass fiber or other biodegradable materials is not ideal, as the properties of these materials may not meet the performance requirements of the plate. However, using composite yarns containing both biodegradable glass fiber and other biodegradable materials allows for the complementary properties of the two materials, resulting in better performance. Specifically, biodegradable glass fiber has good strength and stiffness but poor flexibility, while other biodegradable materials have good flexibility but poor strength and stiffness. Therefore, combining these two materials maintains the rigidity and strength of the plate while increasing its flexibility and toughness, making it more suitable for repair and replacement within the human body. Furthermore, by fabricating composite yarns, the proportion and distribution of different materials can be better controlled, thus better regulating the plate's performance. If a single material is used to fabricate the yarn, the proportion and distribution of the materials cannot be flexibly controlled, making it difficult to meet the performance requirements of the plate.

[0015] The preparation method of the integrally molded three-dimensional biodegradable textile structural rib plate described above involves the following steps: other biodegradable material fiber bundles and biodegradable glass fiber bundles are twisted at a twist rate of 200 twists / 10cm using an S-twist method using a twisting machine; then, the twisted yarn and other biodegradable material fiber bundles are twisted at a twist rate of 200 twists / 10cm using a Z-twist method using a twisting machine to obtain the composite yarn.

[0016] The preparation method of the integrally molded three-dimensional biodegradable textile structural rib plate described above involves the following steps: wrapping other biodegradable material fiber bundles on the surface of biodegradable glass fiber bundles to obtain the composite yarn.

[0017] The preparation method of the integrally molded three-dimensional biodegradable textile structural rib plate described above involves the following steps for preparing the composite yarn: using an injection molding machine, other biodegradable materials (in any form, such as granular or fibrous materials) are heated to a molten state, and biodegradable glass fiber bundles are passed through the molten other biodegradable materials, so that the other biodegradable materials coat the surface of the biodegradable glass fiber bundles, thus obtaining the composite yarn.

[0018] The preparation method of the integrally molded three-dimensional biodegradable textile structural rib plate described above involves the following process for preparing the composite yarn: using two-dimensional weaving technology, biodegradable glass fiber bundles are used as the core yarn, and other biodegradable material fiber bundles are used as the weaving yarn. The spindles are moved regularly by combining a rotary wheel system with a figure-eight track, thus obtaining the composite yarn.

[0019] The preparation method of the integrally molded three-dimensional biodegradable textile structural rib plate described above, wherein the fineness of the biodegradable glass fibers in the biodegradable glass fiber bundle is 100-1600 tex.

[0020] In the preparation method of the integrally molded three-dimensional biodegradable textile structural rib plate described above, the fineness of the other biodegradable material fibers in the other biodegradable material fiber bundle is 100-1600 tex.

[0021] The method for preparing an integrally molded three-dimensional biodegradable textile structural rib, as described above, involves the following steps: during three-dimensional weaving, the weaving angle is 5°-70° and the thickness of the preform is 5-30mm; during three-dimensional machine weaving, the number of layers is 2-12, the warp density is 3-10 threads / cm, and the weft density is determined by the weft-beating force; during three-dimensional knitting, the thickness of the preform is 5-30mm, the warp density is 40-90 threads / 5cm, and the weft density is 40-90 threads / 5cm; during three-dimensional angle interlocking, the number of layers is 2-12, the warp density is 3-10 threads / cm, and the weft density is determined by the weft-beating force.

[0022] The preparation method of the one-piece molded three-dimensional biodegradable textile structural bone plate described above involves heating and curing at a temperature 5-40°C higher than the melting point of other biodegradable materials, for a time of 30-70 minutes.

[0023] The preparation method of the one-piece molded three-dimensional biodegradable textile structural bone plate described above uses a vulcanizing machine for heating, curing and cooling. The pressure of the vulcanizing machine is 10-30 MPa. After preheating for 10 minutes, it is first hot rolled for heating and curing, and then cooled.

[0024] The present invention also provides a three-dimensional biodegradable textile structural rib plate prepared by a method for preparing an integrally molded three-dimensional biodegradable textile structural rib plate as described in any of the preceding claims. The three-dimensional biodegradable textile structural rib plate has higher bending strength than the two-dimensional laminated structure. The bending strength of the three-dimensional biodegradable textile structural rib plate can be increased by more than 20% compared with the two-dimensional laminated composite material with the same material composition. The bending strength of the three-dimensional biodegradable textile structural rib plate exhibited in the three-point bending test is 80-200 MPa.

[0025] Three-dimensional biodegradable textile structural plates also show advantages in tensile strength. Research results show that the tensile strength of three-dimensional biodegradable textile structural plates can be increased by 10%-60% compared with two-dimensional laminated composites with the same material composition. The average tensile strength of three-dimensional biodegradable textile structural plates in tensile tests is 60-200 MPa.

[0026] Three-dimensional biodegradable textile structural plates also show advantages in impact absorption performance, effectively mitigating damage caused by external impacts. Research results show that the impact strength of three-dimensional biodegradable textile structural plates can be increased by 10%-80% compared with two-dimensional laminated composites with the same material composition, and the energy absorption capacity of three-dimensional biodegradable textile structural plates can be increased by 20%-50% compared with two-dimensional laminated composites with the same material composition.

[0027] The three-dimensional biodegradable textile structural rib plate exhibited an average fracture toughness of 1-8 kJ / m in fracture toughness tests. 2 ;

[0028] The three-dimensional biodegradable textile structural bone plate began to gradually degrade in 2 weeks in in vitro simulation experiments and was completely absorbed by the human body within 52 weeks.

[0029] Therefore, it can be seen that the three-dimensional biodegradable textile structure bone plate of the present invention has certain toughness and strength, can stably support the fracture site for a certain period of time, and can be absorbed and degraded by the human body within an appropriate period of time.

[0030] Compared to two-dimensional lamination, three-dimensional biodegradable textile structural plates typically exhibit significant improvements in compressive performance. They can distribute stress and absorb energy more evenly, reducing stress concentration and failure. This improvement can significantly enhance the stability and compressive strength of the plates. The specific percentage increase is influenced by various factors, such as fiber type, fiber content, and the density and form of the weave structure. For specific materials and designs, the compressive strength of three-dimensional biodegradable textile structural plates can be 10%-30% higher than that of two-dimensional laminated composites with the same material composition.

[0031] When using three-dimensional biodegradable textile-structured bone plates to treat fractures, the bone integration time is 6-8 weeks. Generally, the porosity of the three-dimensional textile structure is between 30% and 70%, which provides sufficient space for blood vessel and osteocyte growth and promotes the formation of new bone tissue. Typically, the pore size of the three-dimensional textile structure is between 100 micrometers and 500 micrometers, which provides a suitable growth environment for osteocytes and promotes cell attachment, proliferation, and differentiation.

[0032] Therefore, it can be seen that the three-dimensional biodegradable textile structural bone plate of the present invention provides sufficient support for bone growth.

[0033] Beneficial effects:

[0034] The one-piece molded three-dimensional biodegradable textile structural rib plate prepared by the present invention has good mechanical properties and plasticity. Compared with the traditional two-dimensional laminated structure, the rib plate of this structure does not have interlayer defects and has better mechanical properties and plasticity.

[0035] The one-piece molded three-dimensional biodegradable textile structure bone plate prepared by this invention can be customized in terms of bone plate structure and raw materials according to different patients' fracture conditions and individual differences by adjusting the textile structure and fiber ratio, so as to better adapt to different medical treatment needs.

[0036] The three-dimensional biodegradable textile structural rib plate prepared by the present invention is woven in three dimensions. During the weaving process, holes can be left in appropriate positions in advance so that the rib plate does not need to be drilled after installation. The entire rib plate is integrally formed and does not need to be drilled again after preparation.

[0037] The integrally molded three-dimensional biodegradable textile structure bone plate prepared by this invention can be designed and manufactured according to needs to meet different bone repair requirements in terms of its external dimensions and shape.

[0038] The one-piece molded three-dimensional biodegradable textile structural bone plate prepared by this invention has good biocompatibility and biodegradability, and can be gradually metabolized and absorbed by the human body, avoiding the need for secondary surgery to remove it.

[0039] This invention employs three-dimensional weaving, machine weaving, corner interlocking, and knitting textile structures to create composite yarns from biodegradable fibers of other materials and biodegradable glass fibers. These yarns are then used to create preforms using three-dimensional textile structures. Through heating, curing, and cooling, a rib plate is produced. This process enhances the bonding mechanical properties of the rib plate material in three-dimensional space. These four three-dimensional textile structures improve the bonding strength and adhesion between the rib plate layers. The entire rib plate is integrally formed, uniformly stressed, and requires no lamination. The entire rib plate bears the stress as a whole, resulting in better overall mechanical properties.

[0040] The bone plate of this invention adopts a three-dimensional textile structure. The three-dimensional textile structure uses a three-dimensional weaving method, in which fibers are interwoven and staggered in three dimensions to form a continuous textile network structure. In contrast, two-dimensional laminated composite materials are laminated only on a two-dimensional plane, which easily leads to incomplete bonding between layers, resulting in interlayer porosity and defects. The three-dimensional weaving structure can effectively fill the gaps by interweaving fibers in three-dimensional space, reducing the formation of interlayer porosity. The interweaving and staggering between fibers makes the entire structure more compact and uniform, reducing the generation of air bubbles.

[0041] The bone plate of the present invention adopts a three-dimensional textile structure. The three-dimensional textile structure has the advantage of interlacing and crossing fibers in three dimensions. Through the multi-directional arrangement and crossing of fibers in three-dimensional space, a more uniform and optimized fiber distribution can be achieved. This fiber distribution method can better disperse stress and provide multi-directional strength support, reduce local stress concentration and the formation of weak points. At the same time, the three-dimensional textile structure can also adjust the density and distribution of fibers to adapt to the mechanical requirements of different parts, further optimizing the mechanical properties of the bone plate.

[0042] This invention employs a variety of different three-dimensional textile structures, including three-dimensional weaving, three-dimensional knitting, corner interlocking, and three-dimensional knitting. These structures can be flexibly selected according to different application scenarios and material properties, which can better control the mechanical properties and plasticity of the bone plate. At the same time, the design of these structures can increase the surface area of ​​the material, promote the attachment and growth of bone cells, thereby promoting the support and repair of the bone plate.

[0043] The textile structure preparation methods used in this invention, such as three-dimensional weaving, machine weaving, corner interlocking, and knitting, are relatively simple. By adjusting textile process parameters, such as spinning speed and twist number, the proportion and distribution of biodegradable other material fibers and glass fibers can be effectively controlled, enabling customized design of the rib plate. At the same time, since the three-dimensional textile structure is integrally formed, only integral weaving is required, without the need for interlayer bonding. This preparation method is simple and flexible, improving preparation efficiency and reducing preparation difficulty.

[0044] The three-dimensional textile structure of this invention features interwoven fibers, high structural stability, and strong fiber fixation. Compared with the traditional two-dimensional lamination method, the three-dimensional textile structure can provide a stronger fiber connection, reduce fiber movement and detachment, thereby eliminating the risk of fuzz formation and obtaining a more uniform and clean slab surface. Attached Figure Description

[0045] Figure 1 This is the preform obtained in Embodiment 2 of the present invention. Detailed Implementation

[0046] The present invention will be further described below with reference to specific embodiments. It should be understood that the following embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, it should be understood that after reading the teachings of this invention, those skilled in the art can make various alterations or modifications to the invention, and these equivalent forms also fall within the scope defined by the appended claims.

[0047] The sources of the relevant substances in the embodiments are as follows:

[0048] Biodegradable glass: The preparation method is the same as that of the biodegradable glass fiber in Example 2 of patent CN107043212A;

[0049] Polylactic acid (PLA): Manufacturer: NatureWorks, USA; Grade: 4032D.

[0050] Polycaprolactone (PCL): Manufacturer: Solvay, USA; Grade: 6800;

[0051] Polylactic-glycolic acid (PLGA): Manufacturer: EVONIK CORPORATION, USA; Product code: B6029-1.

[0052] Polyhydroxyalkanoate (PHA): Manufacturer is Mirel (USA), brand name is F1006;

[0053] Polyglycolic acid (PGA): Manufacturer: McLean, Brand: P909206.

[0054] The relevant detection methods in the embodiments are as follows:

[0055] Bending strength of three-dimensional biodegradable textile structural plates: tested according to the standard ASTM D 7246 / D 7246-07 standard test method for bending properties of polymer-based composite materials;

[0056] Average tensile strength of three-dimensional biodegradable textile structural plates: tested according to standard ASTM D 3039 / D 3039M-08 standard test method for tensile properties of polymer-based composite materials;

[0057] Average fracture toughness of three-dimensional biodegradable textile structural plates: The test was conducted in accordance with the standard test method for interlaminar fracture toughness of unidirectional fiber-reinforced polymer matrix composites of type I, as per ASTM D 5528-01(07).

[0058] In vitro simulation experiment: The pharmaceutical standard referenced in the experiment was YYT 0473-2004 In vitro degradation test of polyvinyl chloride copolymers and blends for surgical implants.

[0059] Example 1

[0060] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0061] (1) Raw material preparation:

[0062] Biodegradable glass fiber bundles;

[0063] Other biodegradable fiber bundles: made of polylactic acid, with a single filament fineness of 200 tex;

[0064] (2) Preparation of composite yarn:

[0065] Other biodegradable material fiber bundles and biodegradable glass fiber bundles are twisted together using a twisting machine at a twist rate of 200 twists / 10cm (S-twist). The resulting yarn is then twisted together with other biodegradable material fiber bundles using a twisting machine at a twist rate of 200 twists / 10cm (Z-twist) to obtain a composite yarn. The composite yarn contains 5% biodegradable glass by mass.

[0066] (3) Preparation of preforms:

[0067] The composite yarn is woven into a preform with a thickness of 10mm using a three-dimensional weaving method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0068] In three-dimensional weaving, the weaving angle is 5°;

[0069] (4) Curing and cooling:

[0070] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0071] The vulcanizing machine has a pressure of 10 MPa, requires preheating for 10 minutes before hot rolling, and has a curing temperature that is 5°C higher than the melting point of other biodegradable materials. The curing time is 30 minutes.

[0072] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 90 MPa in the three-point bending test, an average tensile strength of 68 MPa in the tensile test, and an average fracture toughness of 5 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 3 weeks and is completely absorbed by the human body within 27 weeks.

[0073] Example 2

[0074] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0075] (1) Raw material preparation:

[0076] Biodegradable glass fiber bundles;

[0077] Other biodegradable fiber bundles: made of polycaprolactone, with a single filament fineness of 800 tex;

[0078] (2) Preparation of composite yarn:

[0079] Other biodegradable material fiber bundles and biodegradable glass fiber bundles are twisted together using a twisting machine at a twist rate of 200 twists / 10cm (S twist). The resulting yarn and other biodegradable material fiber bundles are then twisted together using a twisting machine at a twist rate of 200 twists / 10cm (Z twist) to obtain a composite yarn. The composite yarn contains 50% biodegradable glass by mass.

[0080] (3) Preparation of preforms:

[0081] The composite yarn is woven into a preform with a thickness of 20mm in the shape of a bone plate using a three-dimensional weaving method (e.g., Figure 1(as shown), and during the weaving process, pre-formed holes are formed in the preform by adding a mold;

[0082] In three-dimensional weaving, the weaving angle is 35°;

[0083] (4) Curing and cooling:

[0084] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0085] The vulcanizing machine has a pressure of 20 MPa, requires 10 minutes of preheating before hot rolling, and has a curing temperature 20°C higher than the melting point of other biodegradable materials. The curing time is 50 minutes.

[0086] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 150 MPa in the three-point bending test, an average tensile strength of 109 MPa in the tensile test, and an average fracture toughness of 2 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 4 weeks and is completely absorbed by the human body within 42 weeks.

[0087] Example 3

[0088] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0089] (1) Raw material preparation:

[0090] Biodegradable glass fiber bundles;

[0091] Other biodegradable fiber bundles: made of polylactic acid, with a single filament fineness of 1500 tex;

[0092] (2) Preparation of composite yarn:

[0093] Other biodegradable material fiber bundles and biodegradable glass fiber bundles are twisted together using a twisting machine at a twist rate of 200 twists / 10cm (S twist). The resulting yarn is then twisted together with other biodegradable material fiber bundles using a twisting machine at a twist rate of 200 twists / 10cm (Z twist) to obtain a composite yarn. The composite yarn contains 95% biodegradable glass by mass.

[0094] (3) Preparation of preforms:

[0095] The composite yarn is woven into a preform with a thickness of 30mm using a three-dimensional weaving method. During the weaving process, pre-formed holes are formed in the preform by adding a mold.

[0096] In three-dimensional weaving, the weaving angle is 70°;

[0097] (4) Curing and cooling:

[0098] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0099] The pressure of the vulcanizing machine is 30 MPa. It needs to be preheated for 10 minutes before hot rolling. The heating and curing temperature is 40°C higher than the melting point of other biodegradable materials, and the heating and curing time is 70 minutes.

[0100] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 200 MPa in the three-point bending test, an average tensile strength of 176 MPa in the tensile test, and an average fracture toughness of 5 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 6 weeks and is completely absorbed by the human body within 46 weeks.

[0101] Example 4

[0102] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0103] (1) Raw material preparation:

[0104] Biodegradable glass fiber bundles;

[0105] Other biodegradable fiber bundles: made of polylactic acid-glycolic acid, with a single filament fineness of 100 tex;

[0106] (2) Preparation of composite yarn:

[0107] Other biodegradable material fiber bundles are wrapped around the surface of biodegradable glass fiber bundles to obtain composite yarn; wherein, the mass content of biodegradable glass in the composite yarn is 5%;

[0108] (3) Preparation of preforms:

[0109] The composite yarn is woven into a preform in the shape of a bone plate using a three-dimensional weaving method, and pre-formed holes are formed in the preform by adding a mold during the weaving process;

[0110] In the three-dimensional weaving process, there are 2 layers and the warp density is 3 threads / cm.

[0111] (4) Curing and cooling:

[0112] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0113] The vulcanizing machine has a pressure of 10 MPa, requires preheating for 10 minutes before hot rolling, and the curing temperature is 10°C higher than the melting point of other biodegradable materials. The curing time is 30 minutes.

[0114] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 78 MPa in the three-point bending test, an average tensile strength of 69 MPa in the tensile test, and an average fracture toughness of 4 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 2 weeks and is completely absorbed by the human body within 28 weeks.

[0115] Example 5

[0116] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0117] (1) Raw material preparation:

[0118] Biodegradable glass fiber bundles;

[0119] Other biodegradable fiber bundles: made of polycaprolactone, with a single filament fineness of 500 tex;

[0120] (2) Preparation of composite yarn:

[0121] By wrapping other biodegradable material fiber bundles on the surface of biodegradable glass fiber bundles, a composite yarn is obtained; wherein, the mass content of biodegradable glass in the composite yarn is 25%;

[0122] (3) Preparation of preforms:

[0123] The composite yarn is woven into a preform in the shape of a bone plate using a three-dimensional weaving method, and pre-formed holes are formed in the preform by adding a mold during the weaving process;

[0124] In the three-dimensional weaving process, there are 6 layers and the warp density is 5 threads / cm;

[0125] (4) Curing and cooling:

[0126] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0127] The pressure of the vulcanizing machine is 20MPa. It needs to be preheated for 10 minutes before hot rolling. The heating and curing temperature is 20℃ higher than the melting point of other biodegradable materials, and the heating and curing time is 70 minutes.

[0128] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 129 MPa in the three-point bending test, an average tensile strength of 100 MPa in the tensile test, and an average fracture toughness of 2 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 3 weeks and is completely absorbed by the human body within 47 weeks.

[0129] Example 6

[0130] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0131] (1) Raw material preparation:

[0132] Biodegradable glass fiber bundles;

[0133] Other biodegradable fiber bundles: made of polylactic acid-glycolic acid, with a single filament fineness of 900 tex;

[0134] (2) Preparation of composite yarn:

[0135] Other biodegradable material fiber bundles are wrapped around the surface of biodegradable glass fiber bundles to obtain composite yarn; wherein, the mass content of biodegradable glass in the composite yarn is 45%;

[0136] (3) Preparation of preforms:

[0137] The composite yarn is woven into a preform in the shape of a bone plate using a three-dimensional weaving method, and pre-formed holes are formed in the preform by adding a mold during the weaving process;

[0138] In the three-dimensional weaving process, there are 12 layers and the warp density is 10 threads / cm.

[0139] (4) Curing and cooling:

[0140] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0141] The vulcanizing machine has a pressure of 30 MPa, requires preheating for 10 minutes before hot rolling, and has a curing temperature that is 30°C higher than the melting point of other biodegradable materials. The curing time is 50 minutes.

[0142] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 124 MPa in the three-point bending test, an average tensile strength of 76 MPa in the tensile test, and an average fracture toughness of 4 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 2 weeks and is completely absorbed by the human body within 36 weeks.

[0143] Example 7

[0144] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0145] (1) Raw material preparation:

[0146] Biodegradable glass fiber bundles;

[0147] Other biodegradable materials: polylactic acid-glycolic acid;

[0148] (2) Preparation of composite yarn:

[0149] Using an injection molding machine, other biodegradable materials are heated to a molten state, and biodegradable glass fiber bundles are passed through the molten other biodegradable materials, so that the other biodegradable materials coat the surface of the biodegradable glass fiber bundles, thus obtaining a composite yarn; wherein, the mass content of biodegradable glass in the composite yarn is 10%;

[0150] (3) Preparation of preforms:

[0151] The composite yarn is woven into a preform with a thickness of 10mm using a three-dimensional knitting method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0152] In three-dimensional knitting, the horizontal density is 40 threads / 5cm and the vertical density is 40 threads / 5cm.

[0153] (4) Curing and cooling:

[0154] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0155] The vulcanizing machine has a pressure of 10 MPa, requires preheating for 10 minutes before hot rolling, and the curing temperature is 10°C higher than the melting point of other biodegradable materials. The curing time is 30 minutes.

[0156] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 96 MPa in the three-point bending test, an average tensile strength of 101 MPa in the tensile test, and an average fracture toughness of 5 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 2 weeks and is completely absorbed by the human body within 26 weeks.

[0157] Example 8

[0158] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0159] (1) Raw material preparation:

[0160] Biodegradable glass fiber bundles;

[0161] Other biodegradable materials: polyhydroxyalkanoates;

[0162] (2) Preparation of composite yarn:

[0163] Using an injection molding machine, other biodegradable materials are heated to a molten state, and biodegradable glass fiber bundles are passed through the molten other biodegradable materials, so that the other biodegradable materials coat the surface of the biodegradable glass fiber bundles, thus obtaining a composite yarn; wherein the mass content of biodegradable glass in the composite yarn is 60%;

[0164] (3) Preparation of preforms:

[0165] The composite yarn is woven into a preform with a thickness of 20mm using a three-dimensional knitting method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0166] In three-dimensional knitting, the horizontal density is 70 threads / 5cm and the vertical density is 50 threads / 5cm.

[0167] (4) Curing and cooling:

[0168] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0169] The pressure of the vulcanizing machine is 20MPa. It needs to be preheated for 10 minutes before hot rolling. The heating and curing temperature is 20℃ higher than the melting point of other biodegradable materials, and the heating and curing time is 70 minutes.

[0170] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 134 MPa in the three-point bending test, an average tensile strength of 145 MPa in the tensile test, and an average fracture toughness of 4 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 7 weeks and is completely absorbed by the human body within 48 weeks.

[0171] Example 9

[0172] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0173] (1) Raw material preparation:

[0174] Biodegradable glass fiber bundles;

[0175] Other biodegradable materials: a mixture of polylactic acid-glycolic acid and polyhydroxyalkanoate in a 1:1 mass ratio;

[0176] (2) Preparation of composite yarn:

[0177] Using an injection molding machine, other biodegradable materials are heated to a molten state, and biodegradable glass fiber bundles are passed through the molten other biodegradable materials, so that the other biodegradable materials coat the surface of the biodegradable glass fiber bundles, thus obtaining a composite yarn; wherein the mass content of biodegradable glass in the composite yarn is 80%;

[0178] (3) Preparation of preforms:

[0179] The composite yarn is woven into a preform with a thickness of 30mm using a three-dimensional knitting method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0180] In three-dimensional knitting, the horizontal density is 90 threads / 5cm and the vertical density is 90 threads / 5cm.

[0181] (4) Curing and cooling:

[0182] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0183] The vulcanizing machine has a pressure of 30 MPa, requires preheating for 10 minutes before hot rolling, and has a curing temperature that is 30°C higher than the melting point of other biodegradable materials. The curing time is 50 minutes.

[0184] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 157 MPa in the three-point bending test, an average tensile strength of 178 MPa in the tensile test, and an average fracture toughness of 8 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 5 weeks and is completely absorbed by the human body within 37 weeks.

[0185] Example 10

[0186] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0187] (1) Raw material preparation:

[0188] Biodegradable glass fiber bundles;

[0189] Other biodegradable fiber bundles: made of polyhydroxyalkanoates, with a single filament fineness of 250 tex;

[0190] (2) Preparation of composite yarn:

[0191] Using two-dimensional weaving technology, biodegradable glass fiber bundles are used as the core yarn, and other biodegradable material fiber bundles are used as the weaving yarn. The spindles are moved in a regular manner by using a combination of a rotary wheel system and a figure-eight track, thus obtaining a composite yarn. The biodegradable glass content in the composite yarn is 20%.

[0192] (3) Preparation of preforms:

[0193] The composite yarn is woven into a preform in the shape of a bone plate using a three-dimensional interlocking method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0194] In the case of three-dimensional interlocking, the number of layers is 2, and the warp density is 3 wires / cm;

[0195] (4) Curing and cooling:

[0196] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0197] The vulcanizing machine has a pressure of 10 MPa, requires preheating for 10 minutes before hot rolling, and the curing temperature is 10°C higher than the melting point of other biodegradable materials. The curing time is 30 minutes.

[0198] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 98 MPa in the three-point bending test, an average tensile strength of 67 MPa in the tensile test, and an average fracture toughness of 6 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 5 weeks and is completely absorbed by the human body within 39 weeks.

[0199] Example 11

[0200] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0201] (1) Raw material preparation:

[0202] Biodegradable glass fiber bundles;

[0203] Other biodegradable fiber bundles: made of polyhydroxyalkanoates, with a single filament fineness of 1000 tex;

[0204] (2) Preparation of composite yarn:

[0205] Using two-dimensional weaving technology, biodegradable glass fiber bundles are used as the core yarn, and other biodegradable material fiber bundles are used as the weaving yarn. The regular movement of the spindle is achieved by combining a rotary wheel system with a figure-eight track, thus obtaining a composite yarn. The biodegradable glass content in the composite yarn is 60%.

[0206] (3) Preparation of preforms:

[0207] The composite yarn is woven into a preform in the shape of a bone plate using a three-dimensional interlocking method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0208] In the case of three-dimensional interlocking, the number of layers is 6, and the warp density is 7 threads / cm;

[0209] (4) Curing and cooling:

[0210] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0211] The pressure of the vulcanizing machine is 20MPa. It needs to be preheated for 10 minutes before hot rolling. The heating and curing temperature is 20℃ higher than the melting point of other biodegradable materials, and the heating and curing time is 70 minutes.

[0212] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 154 MPa in the three-point bending test, an average tensile strength of 157 MPa in the tensile test, and an average fracture toughness of 4 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades within 7 weeks and is completely absorbed by the human body within 47 weeks.

[0213] Example 12

[0214] A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, the specific steps of which are as follows:

[0215] (1) Raw material preparation:

[0216] Biodegradable glass fiber bundles;

[0217] Other biodegradable fiber bundles: made of polyglycolic acid, with a single filament fineness of 1500 tex;

[0218] (2) Preparation of composite yarn:

[0219] Using two-dimensional weaving technology, biodegradable glass fiber bundles are used as the core yarn, and other biodegradable material fiber bundles are used as the weaving yarn. The regular movement of the spindle is achieved by using a combination of a rotary wheel system and a figure-eight track, thus obtaining a composite yarn. The biodegradable glass content in the composite yarn is 80%.

[0220] (3) Preparation of preforms:

[0221] The composite yarn is woven into a preform in the shape of a bone plate using a three-dimensional interlocking method, and pre-formed holes are formed in the preform by adding a mold during the weaving process.

[0222] In the case of three-dimensional interlocking, the number of layers is 12, and the warp density is 10 strands / cm;

[0223] (4) Curing and cooling:

[0224] Using a vulcanizing machine, the preform is first hot-rolled and then heated and cured, followed by cooling treatment to obtain an integrally formed three-dimensional biodegradable textile structural rib plate.

[0225] The vulcanizing machine has a pressure of 30 MPa, requires preheating for 10 minutes before hot rolling, and has a curing temperature that is 30°C higher than the melting point of other biodegradable materials. The curing time is 50 minutes.

[0226] The final fabricated three-dimensional biodegradable textile structural plate exhibited a bending strength of 198 MPa in the three-point bending test, an average tensile strength of 179 MPa in the tensile test, and an average fracture toughness of 5 kJ / m in the fracture toughness test. 2 In in vitro simulation experiments, it gradually degrades over 9 weeks and is completely absorbed by the human body over 49 weeks.

Claims

1. A method for preparing a one-piece molded three-dimensional biodegradable textile structural rib plate, characterized in that, Composite yarns composed of biodegradable glass fibers and other biodegradable materials are woven into a preform in the shape of a bone plate through three-dimensional weaving, three-dimensional machine weaving, three-dimensional knitting or three-dimensional interlocking. During the weaving process, pre-made holes are formed in the preform by adding a mold. The preform is then subjected to heating, curing and cooling treatments in sequence to obtain an integrally formed three-dimensional biodegradable textile structure bone plate. The fibers in the preform are interwoven and staggered in three dimensions to form a continuous textile network structure. The process of preparing composite yarn is as follows: using an injection molding machine, other biodegradable materials are heated to a molten state, and biodegradable glass fiber bundles are passed through the middle of the other biodegradable materials in the molten state, so that the other biodegradable materials are coated on the surface of the biodegradable glass fiber bundles, thus obtaining composite yarn; In three-dimensional knitting, the knitting angle is 5°-70°, and the thickness of the preform is 5-30mm; in three-dimensional machine knitting, the number of layers is 2-12, and the warp density is 3-10 threads / cm; in three-dimensional knitting, the thickness of the preform is 5-30mm, the warp density is 40-90 threads / 5cm, and the longitudinal density is 40-90 threads / 5cm; in three-dimensional angle interlocking, the number of layers is 2-12, and the warp density is 3-10 threads / cm.

2. The method for preparing an integrally molded three-dimensional biodegradable textile structural rib plate according to claim 1, characterized in that, The mass content of biodegradable glass fiber in composite yarns is 5%-95%.

3. The method for preparing an integrally molded three-dimensional biodegradable textile structural rib plate according to claim 1, characterized in that, Other biodegradable materials include one or more of polylactic acid, polycaprolactone, polylactic-hydroxyacetic acid, polyhydroxyalkyl esters, and polyesters.

4. The method for preparing an integrally molded three-dimensional biodegradable textile structural rib plate according to claim 1, characterized in that, The process of preparing composite yarn is as follows: other biodegradable material fiber bundles and biodegradable glass fiber bundles are twisted by a twisting machine at a twist of 200 twists / 10cm with S twist. Then, the twisted yarn and other biodegradable material fiber bundles are twisted by a twisting machine at a twist of 200 twists / 10cm with Z twist to obtain composite yarn.

5. The method for preparing an integrally molded three-dimensional biodegradable textile structural rib plate according to claim 1, characterized in that, The heating and curing temperature is 5-40℃ higher than the melting point of other biodegradable materials, and the time is 30-70 minutes.

6. A three-dimensional biodegradable textile structural rib plate prepared by the method for preparing an integrally molded three-dimensional biodegradable textile structural rib plate according to any one of claims 1-5, characterized in that, The three-dimensional biodegradable textile structural rib plate exhibited a bending strength of 80-200 MPa in a three-point bending test; The three-dimensional biodegradable textile structural plates exhibited an average tensile strength of 60-200 MPa in tensile tests. The three-dimensional biodegradable textile structural plate exhibited an average fracture toughness of 1-8 kJ / m² in fracture toughness tests. The three-dimensional biodegradable textile structural bone plate began to degrade gradually in 2 weeks in in vitro simulation experiments and was completely absorbed by the human body within 52 weeks.

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