Anticorrosion and fresh-keeping trademark sticker, and preparation method and application thereof

Abstract

The application discloses an anti-corrosion and fresh-keeping trademark sticker and a preparation method and application thereof. The anti-corrosion and fresh-keeping trademark sticker is formed by bonding a soluble microneedle patch and a base sealing material; the soluble microneedle patch is composed of a microneedle body and a base layer, the microneedle body is prepared from raw materials including epsilon-polylysine and polyvinyl alcohol, and the mass ratio of the epsilon-polylysine to the polyvinyl alcohol is 1:9-9:1. The microneedle system can promote the transdermal diffusion of epsilon-polylysine to fruits and vegetables, the epsilon-polylysine contained in the needle body of the trademark sticker is released along with the dissolution of the soluble microneedle needle body when the trademark sticker is attached to the surface of crops such as fruits, so that the anti-corrosion and fresh-keeping effect of epsilon-polylysine on the surface of crops such as fruits is improved, and the economic cost is reduced.

Description

Technical Field

[0001] This invention belongs to the field of food preservation and anti-corrosion technology, specifically relating to anti-corrosion and food preservation labeling, its preparation method and application. Background Technology

[0002] Citrus is one of the world's most important economic crops. During post-harvest storage and transportation, citrus fruits are susceptible to diseases such as Penicillium mold, green mold, stem rot, black rot, and anthracnose. Among these, Penicillium mold is the main disease affecting storage and transportation; once infected, the disease spreads rapidly, potentially causing the entire fruit to rot and emit an unpleasant odor within days, resulting in severe economic losses.

[0003] According to Article 6, "Preservation and Anti-corrosion," of the Chinese agricultural industry standard NY / T 1189-2017 "Citrus Storage," citrus fruits should be treated with prescribed preservatives within 24 hours of arriving at the harvesting and processing plant. There are 115 registered pesticide products in my country used for post-harvest fruit soaking for sterilization and preservation of citrus fruits, with seven active ingredients: imazalil, prochloraz, biguanide trioctylbenzene sulfonate (Bac-K), Bacillus subtilis, thiophanate-methyl, thiabendazole, and sodium chlorophenoxyacetate. The safety interval (from the time of treatment to market release) is 10-60 days. Although my country has relevant guidelines on the use of citrus preservatives, they are insufficient, lacking more detailed guidelines and leading to misuse and abuse in practice. Some citrus producers, in order to ensure the appearance of their fruits, arbitrarily increase the concentration of preservatives or ignore the safety interval before selling them directly to the market.

[0004] As consumers demand increasingly higher quality and green agricultural products, requiring both extended shelf life and reduced health risks, edible preservatives are gradually gaining attention. Currently, commercially available edible preservatives include chitosan and ε-polylysine (ε-PL). For fruits and other agricultural products, chitosan, due to its excellent film-forming properties, can be made into a coating material, used as a preservative during storage to reduce spoilage. Other preservatives are mostly applied through large-area coating, spraying, or soaking to achieve preservation. However, regardless of the method—whether using plastic wrap, coating, spraying, or soaking—preservatives cannot penetrate the interior of fruits and other agricultural products, leading to increased costs and poor preservation results.

[0005] A trademark is a sign used to identify and distinguish the source of goods or services. Trademark stickers are typically used as identification signs, printed with graphics and text that primarily serve to identify and indicate products. There are no reports of trademark stickers having anti-corrosion or preservation properties. Summary of the Invention

[0006] Based on this, the present invention provides an anti-corrosion and preservation label, which is made of soluble microneedle patches containing ε-polylysine and a base sealing material. The microneedles of the anti-corrosion and preservation label have good mechanical properties and can penetrate into the fruit peel. The ε-PL contained therein will be released as the soluble microneedles dissolve, thereby effectively improving the penetration of ε-PL into the surface of fruits and other crops, and improving the anti-corrosion and preservation effect of ε-PL on the surface of fruits and other crops.

[0007] The present invention includes the following technical solutions.

[0008] A type of anti-corrosion and preservation label is made of soluble microneedle patches and a base sealing material bonded together;

[0009] The soluble microneedle patch consists of a microneedle body and a base layer. The microneedle body is prepared from raw materials including ε-polylysine and polyvinyl alcohol, and the mass ratio of ε-polylysine to polyvinyl alcohol is 1:9-9:1.

[0010] In some embodiments, the mass ratio of ε-polylysine to polyvinyl alcohol is 3:7-8:2.

[0011] In some embodiments, the mass ratio of ε-polylysine to polyvinyl alcohol is 3:7 to 7:3.

[0012] In some embodiments, the mass ratio of ε-polylysine to polyvinyl alcohol is 5:5-7:3.

[0013] In some embodiments, the mass ratio of ε-polylysine to polyvinyl alcohol is 5:5.

[0014] In some embodiments, the mass ratio of ε-polylysine to polyvinyl alcohol is 7:3.

[0015] In some embodiments, the polyvinyl alcohol is PVA-103.

[0016] In some embodiments, the substrate sealing material is selected from thermal paper, non-woven fabric, and pressure-sensitive adhesive.

[0017] In some embodiments, the raw materials for preparing the microneedles also include non-ε-polylysine food additives and / or other preservatives.

[0018] In some embodiments, the non-ε-polylysine food additive and / or other preservative is potassium sorbate.

[0019] In some embodiments, the substrate layer is prepared from a raw material including polyvinylpyrrolidone.

[0020] In some embodiments, the substrate layer is prepared from a raw material including polyvinylpyrrolidone K90.

[0021] This invention also provides a method for preparing the aforementioned anti-corrosion and preservation label. It includes the following technical solution:

[0022] A method for preparing the aforementioned anti-corrosion and preservation label includes the following steps:

[0023] Preparation of the needle solution: Mix an aqueous solution containing ε-polylysine and an aqueous solution containing polyvinyl alcohol according to the ratio of solutes in the aqueous solution, heat and mix at 45±5℃, remove air bubbles by sonication, and remove insoluble matter by centrifugation to obtain the needle solution.

[0024] Preparation of soluble microneedle patch: The needle solution is added to the microneedle negative mold, centrifuged, excess needle solution is scraped off, centrifuged and dried, then a base liquid is added and centrifuged again; the microneedle negative mold is dried and the microneedles are peeled off to obtain the soluble microneedle patch; wherein, the base liquid is an ethanol solution containing polyvinylpyrrolidone.

[0025] Preparation of the anti-corrosion and preservation label: The soluble microneedle patch is bonded to the base sealing material to obtain the anti-corrosion and preservation label.

[0026] In some embodiments, the ratio of ε-polylysine to water in the aqueous solution containing ε-polylysine is 1g:0.5mL-10mL.

[0027] In some embodiments, the ratio of ε-polylysine to water in the aqueous solution containing ε-polylysine is 1g:1mL-5mL.

[0028] In some embodiments, the ratio of ε-polylysine to water in the aqueous solution containing ε-polylysine is 1g:1.5mL-2mL.

[0029] In some embodiments, the ratio of polyvinyl alcohol to water in the aqueous solution containing polyvinyl alcohol is 1g:0.5mL-10mL.

[0030] In some embodiments, the ratio of polyvinyl alcohol to water in the aqueous solution containing polyvinyl alcohol is 1g:1mL-5mL.

[0031] In some embodiments, the ratio of polyvinyl alcohol to water in the aqueous solution containing polyvinyl alcohol is 1g:1.5mL-2mL.

[0032] In some embodiments, the ratio of polyvinylpyrrolidone to ethanol in the base solution is 1g:2mL-8mL.

[0033] In some embodiments, the ratio of polyvinylpyrrolidone to ethanol in the base solution is 1g:3.5mL-4mL.

[0034] The present invention also provides the uses of the soluble microneedle patch and the preservative label. These include the following technical solutions.

[0035] The use of the soluble microneedle patch in the preparation of preservative materials for food preservation.

[0036] The use of the preservative label in the preparation of preservative materials for food preservation.

[0037] In some embodiments, the food is fruit, vegetables, or meat.

[0038] In some of these embodiments, the food is a citrus fruit.

[0039] In recent years, microneedle formulations have been developed, primarily for use in the pharmaceutical and cosmetic industries. Microneedles can be categorized by their delivery method into solid microneedles, coated microneedles, soluble microneedles, and hollow microneedles. Soluble microneedles, after penetrating the stratum corneum, release the functional drug components contained within the needle as it dissolves, achieving drug absorption by the subcutaneous tissue and the body. Soluble microneedles only require removal of the dressing after administration, offering advantages such as safety, non-invasiveness, and high efficiency, resulting in good patient compliance and promising future development prospects. It is a drug delivery method with advantages of good permeability, precision, and quantitative release.

[0040] ε-PL, a natural amino acid polymer produced through bio-fermentation, is known for its strong antibacterial effect, high safety, and good thermal stability. It possesses broad-spectrum bactericidal properties and was approved by the FDA as a safe food preservative in October 2003. my country also permitted ε-PL as a food additive in 2014, demonstrating promising prospects in food preservation and maintenance. Currently, ε-PL is widely used in meat, pastries, and fruit and vegetable juices. However, for citrus fruits and other agricultural products, ε-PL can only be applied or sprayed onto the surface and cannot penetrate the interior, thus reducing its antiseptic and antibacterial effects and further increasing preservation costs.

[0041] This invention combines ε-PL with polyvinyl alcohol, an auxiliary material that improves the mechanical properties of needle tips, to create an ε-PL soluble microneedle patch (hereinafter referred to as a microneedle, patch, or microneedle patch). This microneedle patch exhibits excellent mechanical properties. The patch is then further processed into an anti-corrosion and preservation label. The microneedles promote the transdermal diffusion of ε-PL into fruits and vegetables. By applying the label to the surface of fruits and other crops, the ε-PL contained in the needles of the patch is released as the soluble microneedles dissolve, thereby effectively improving the penetration of ε-PL into the skin of fruits and other crops, enhancing the anti-corrosion and preservation effect of ε-PL on the surface of fruits and other crops, and reducing economic costs.

[0042] Therefore, the anti-corrosion and preservation label of the present invention has the following beneficial effects:

[0043] 1. The microneedle patch prepared by combining ε-PL and a specific microneedle excipient, polyvinyl alcohol, in the anti-corrosion and preservation label has excellent mechanical properties, which can penetrate into the fruit peel, allowing ε-PL to effectively penetrate into the interior of fruits such as citrus, thereby improving the anti-corrosion and preservation effect.

[0044] 2. When using the anti-corrosion and preservation label, simply stick it on the surface of fruits such as oranges. The operation is simple. Compared with methods such as spraying large areas of preservatives, applying the anti-corrosion and preservation label can effectively reduce economic costs and achieve precise and quantitative anti-corrosion and preservation effects.

[0045] 3. The microneedle patch can be made into an anti-corrosion and preservation label, combining preservation and promotion in one; moreover, the label can seal the micropores formed by the needles in the patch, isolating water, air and bacteria, which can further improve the preservation effect. Attached Figure Description

[0046] Figure 1 The soluble microneedle patch prepared in Example 1.

[0047] Figure 2 Micrographs of the soluble microneedle patches prepared with the 6 needle solution formulation in Example 2: (a) pure ε-PL; (b) ε-PL:PVP k30 = 1:1; (c) EPL:Dex 40 = 1:1; (d) ε-PL:PVP k30:PVA-103 = 45:45:10; (e) ε-PL:Dex 40:PVA-103 = 45:45:10; (f) ε-PL:PVA-103 = 5:5.

[0048] Figure 3 This is a photograph of the orange peel puncture performance test of the soluble microneedle patch with a mass ratio of ε-polylysine to polyvinyl alcohol of 1:9-9:1 in Example 3.

[0049] Figure 4The puncture rate of the soluble microneedle patch with a mass ratio of ε-polylysine to polyvinyl alcohol of 1:9-9:1 in Example 3 after puncturing orange peel.

[0050] Figure 5 This is an HE-stained section of orange peel after puncturing orange peel using a soluble microneedle patch with a mass ratio of 7:3 of ε-polylysine and polyvinyl alcohol, as described in Example 3.

[0051] Figure 6 This is a diffusion diagram of Cy7-labeled ε-PL onto intact citrus fruit after microneedle administration in Example 4.

[0052] Figure 7 This is a graph showing the change in the diffusion range of Cy7-labeled ε-PL on citrus peel over time after microneedle administration in Example 4.

[0053] Figure 8 This is a statistical graph showing the diffusion range of ε-PL on citrus peel over time after microneedle administration in Example 4.

[0054] Figure 9 The anti-corrosion and preservation label prepared in Example 5.

[0055] Figure 10 This is a diagram illustrating the application of preservative labels to citrus fruits. Detailed Implementation

[0056] Unless otherwise specified, the practice of this invention will utilize molecular biology, pharmaceutics, and cell biology, which are within the scope of this art. Experimental methods in the following examples, unless otherwise specified, are generally performed under conventional conditions or as recommended by the manufacturer. All commonly used chemical reagents used in the examples are commercially available products.

[0057] Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the invention. The term "and / or" as used in this invention includes any and all combinations of one or more of the associated listed items.

[0058] The following will provide a more detailed description of the ε-PL-based anti-corrosion and preservation label of the present invention in conjunction with specific embodiments and accompanying drawings. Those skilled in the art should understand that the following description is illustrative and not restrictive, and should not be construed as limiting the scope of protection of the present invention.

[0059] The ε-polylysine (ε-PL) used in the following examples was purchased from Zhengzhou Bainafo Biotechnology.

[0060] PVA-103 was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0061] The PVP k90 was purchased from BASF in Germany.

[0062] Example 1: Preparation of soluble microneedle patches based on ε-PL

[0063] 1. Preparation of microneedle negative mold

[0064] A pyramidal metal microneedle male mold (microneedle height 1200 μm, base width 300 μm, tip spacing 800 μm, number of microneedles 12×12) was placed in anhydrous ethanol and sonicated for 20 minutes. After repeated cleaning, the male mold was placed at room temperature to allow the ethanol on its surface to completely evaporate. 9 mL of polydimethylsiloxane (PDMS) and 0.9 mL of curing agent (Dow Corning, USA) were mixed at a ratio of 10:1 (w / w) and stirred until homogeneous. The mixture was then degassed under vacuum for approximately 10 minutes. The degassed liquid PDMS containing the curing agent was slowly poured into the male mold (6 g), and then placed in a vacuum drying oven. A vacuum pump was connected and the mold was degassed for 45 minutes until no bubbles remained on the liquid surface. The male mold was then placed in an 80°C oven for curing for 2 hours until the PDMS was completely solidified. The male mold was then removed, cooled, and the female mold was separated.

[0065] 2. Preparation of needle solution and base solution

[0066] ε-PL (10g) was dissolved in 18mL of ultrapure water at a ratio of 1:1.8 (w / v), and the solution was shaken well to obtain the ε-PL solution. PVA-103 (10g) was dissolved in 18mL of ultrapure water at a ratio of 1:1.8 (w / v), and the solution was stirred and allowed to swell overnight. Then, it was heated at 90℃ for more than 2 hours, shaking regularly during heating to obtain the PVA-103 solution. The ε-PL solution and PVA-103 solution were mixed at a ratio of 7:3 (w / w), stirred in a 45℃ water bath for 2 hours, sonicated for 5 minutes to remove air bubbles, and then centrifuged at 4000rpm for 5 minutes to precipitate insoluble matter. The supernatant was used as the syringe solution.

[0067] Dissolve 10g of PVP k90 in 38mL of ethanol at a ratio of 1:3.8 (w / v), stir well with a spoon until swollen. The next day, stir thoroughly again, centrifuge at 2000rpm for 2 minutes to remove air bubbles, collect the supernatant to obtain the base solution, and add it to the syringe along the wall.

[0068] 3. Preparation of microneedle patches

[0069] Add 250 μL of the needle solution to the microneedle negative mold, balance the mixture, and centrifuge (4000 rpm, 10 min, 0-10℃) until the mold is completely filled. Remove excess solution with a clean scraper, then centrifuge again to dry (4000 rpm, 45 min, 20-30℃). Add PVP K90 base solution and centrifuge (4000 rpm, 45 min, 0-10℃). Place the microneedle negative mold in a drying oven and dry for at least 72 hours. Peel off the microneedles and store them in a sealed desiccator for later use.

[0070] The microneedles are gently removed from the mold to obtain a soluble microneedle patch with intact needle shape, such as... Figure 1 As shown.

[0071] To investigate the antifungal potential of ε-PL microneedles, the tips (needle bodies) of ε-PL microneedle patches were isolated, and the ε-PL content in the tips was measured using high-performance liquid chromatography (HPLC). The results showed that the ε-PL microneedle patches had a very high drug loading capacity, with each patch (13mm × 13mm) containing up to 1890 μg of ε-PL. Since extensive literature has confirmed that the inhibitory effect of ε-PL on fungi is concentration-dependent, the high ε-PL loading capacity implies that the microneedles can exert a higher antibacterial effect.

[0072] Example 2: Comparison of microneedle patches prepared with different excipient combinations

[0073] PVP, PVA, or dextran (Dex 40) were selected as needle excipients and compounded with ε-PL in different proportions to improve needle tip performance. PVP K90 with an average molecular weight of 1300 kDa was selected as the base layer material to prepare different soluble microneedle patches (other parameters are the same as the preparation method in Example 1).

[0074] The experimental results are shown in Figure 2 The quality of microneedles prepared by combining ε-PL with different excipients in different proportions varies. When ε-PL is used alone or combined with PVP k30 and Dex 40 alone, the prepared microneedles have an uneven texture and a high breakage rate. However, when a certain proportion of PVA-103 is added to the formulation, the breakage rate of the prepared microneedles is greatly reduced. The microneedles prepared by combining ε-PL and PVA-103 have a uniform texture and are completely transparent.

[0075] Example 3: Orange Peel Puncture Performance Test of Microneedle Patches

[0076] The orange peel puncture performance test of ε-PL soluble microneedle patches was conducted according to the following method:

[0077] Soluble microneedle patches were prepared according to the method in Example 1, using ε-polylysine and polyvinyl alcohol in a mass ratio of 1:9-9:1 as the needle material.

[0078] Wash and dry the oranges. Insert the prepared microneedle patch into the orange peel with the same force, press for 1 minute, and remove the microneedles after 4 minutes. Wash away the dissolved microneedle liquid with water. Immerse the orange peel surface in 4% (0.4g / 10mL) trypan blue solution for 2 minutes, then remove the trypan blue with water. Small pores of staining can be observed on the orange peel surface, proving that the microneedles prepared in this invention have good mechanical strength and good puncture effect (e.g., Figure 3 (As shown).

[0079] Figure 4 The results show that the soluble microneedle patch obtained by using the ε-PL:PVA-103 = 7:3 formulation has the best mechanical strength and the best puncture performance on the fruit peel, with a puncture rate of over 99%.

[0080] Figure 5 The results show that the soluble microneedle patch obtained by using the ε-PL:PVA-103 = 7:3 formulation can form obvious micropore channels in citrus peel with a depth between 660 and 920 meters.

[0081] Example 4: Microneedle-mediated delivery of ε-PL to citrus

[0082] When microneedles are used in fruit preservatives, drug distribution may primarily occur through concentration gradient-mediated diffusion. Therefore, to evaluate the unique mechanism of action of microneedles applied topically in fruit, this embodiment fabricated microneedle patches using Cy7-labeled ε-PL (prepared according to the method of Example 1 using Cy7-labeled ε-PL instead of ε-PL as the raw material), and then applied them to the surfaces of whole citrus fruits and separated peels for 5 min, respectively. After different time intervals, fluorescence imaging of the citrus fruits and detached peels was performed using a live-cell imaging system to test the diffusion of ε-PL onto the whole citrus fruits and citrus peels at different time points.

[0083] The results showed that ε-PL rapidly diffused on intact citrus fruits within 6 hours, and the distribution area of ​​ε-PL continued to increase over a period of 72 hours. Figure 6 To quantify the distribution of ε-PL on the peel, the citrus peel was further separated, microneedles were applied to the center of the peel, and the diameter of the fluorescent region was measured. Figure 7 As shown, a large concentration gradient promoted the rapid diffusion of ε-PL from the microneedle patch to the pericarp, forming a fluorescent region with a diameter of 51.1 ± 3.3 mm, which continued to increase to 58 ± 12.8 mm after 72 h. Figure 8 These results indicate that although microneedle patches are distributed primarily through diffusion, they can deliver ε-PL into the peel and form a large drug distribution area, showing great potential in reducing the occurrence of localized invasive fungal infections in citrus peels.

[0084] Example 5: Use of microneedle patches as anti-corrosion and preservation label

[0085] The soluble microneedle patch prepared in Example 1 was bonded to a thermal paper sticker to obtain an anti-corrosion and freshness-preserving label sticker, such as... Figure 9 As shown.

[0086] Apply the preservative label to the orange (e.g.) Figure 10 As shown, it can both prevent spoilage and preserve freshness, and also serve as a trademark for advertising.

[0087] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A preservative and food-keeping label, characterized in that, It is made of soluble microneedle patches and a base sealing material bonded together; The soluble microneedle patch consists of a microneedle body and a base layer. The microneedle body is prepared from ε-polylysine and polyvinyl alcohol, and the mass ratio of ε-polylysine to polyvinyl alcohol is 5:5-7:

3. The polyvinyl alcohol is PVA-103.

2. The anti-corrosion and preservation label according to claim 1, characterized in that, The mass ratio of ε-polylysine to polyvinyl alcohol is 5:5 or 7:

3.

3. The anti-corrosion and preservation label according to claim 1 or 2, characterized in that, The substrate sealing material is selected from thermal paper, non-woven fabric, and pressure-sensitive adhesive.

4. The anti-corrosion and preservation label according to claim 1 or 2, characterized in that, The base layer is made from raw materials including polyvinylpyrrolidone.

5. The anti-corrosion and preservation label according to claim 4, characterized in that, The base layer is prepared from raw materials including polyvinylpyrrolidone K90.

6. A method for preparing an anti-corrosion and preservation label according to any one of claims 1-5, characterized in that, Includes the following steps: Preparation of the needle solution: Mix an aqueous solution containing ε-polylysine and an aqueous solution containing polyvinyl alcohol according to the ratio of solutes in the aqueous solution, heat and mix at 45±5℃, remove air bubbles by sonication, and remove insoluble matter by centrifugation to obtain the needle solution. Preparation of soluble microneedle patch: The needle solution is added to the microneedle negative mold, centrifuged, excess needle solution is scraped off, centrifuged and dried, then a base liquid is added and centrifuged again; the microneedle negative mold is dried and the microneedles are peeled off to obtain the soluble microneedle patch; wherein, the base liquid is an ethanol solution containing polyvinylpyrrolidone. Preparation of the anti-corrosion and preservation label: The soluble microneedle patch is bonded to the base sealing material to obtain the anti-corrosion and preservation label.

7. The method for preparing the anti-corrosion and preservation label according to claim 6, characterized in that, The aqueous solution containing ε-polylysine has an ε-polylysine to water ratio of 1g:0.5mL-10mL; and / or, The ratio of polyvinyl alcohol to water in the aqueous solution containing polyvinyl alcohol is 1g:0.5mL-10mL; and / or, The ratio of polyvinylpyrrolidone and ethanol in the base solution is 1g: 2mL-8mL.

8. The method for preparing the anti-corrosion and preservation label according to claim 7, characterized in that, The ratio of ε-polylysine to water in the aqueous solution containing ε-polylysine is 1g:1mL-5mL.

9. The method for preparing the anti-corrosion and preservation label according to claim 8, characterized in that, The ratio of ε-polylysine to water in the aqueous solution containing ε-polylysine is 1g:1.5mL-2mL.

10. The method for preparing the anti-corrosion and preservation label according to claim 7, characterized in that, The ratio of polyvinyl alcohol to water in the aqueous solution containing polyvinyl alcohol is 1g:1mL-5mL.

11. The method for preparing the anti-corrosion and preservation label according to claim 10, characterized in that, The ratio of polyvinyl alcohol to water in the aqueous solution containing polyvinyl alcohol is 1g:1.5mL-2mL.

12. The method for preparing the anti-corrosion and preservation label according to claim 7, characterized in that, The ratio of polyvinylpyrrolidone and ethanol in the base solution is 1g: 3.5mL-4mL.

13. Use of the soluble microneedle patch as described in any one of claims 1-5 or the preservative label as described in any one of claims 1-5 in the preparation of preservative materials for food preservation.

14. The use according to claim 13, characterized in that, The food items mentioned are fruits, vegetables, and meat.

15. The use according to claim 14, characterized in that, The food in question is citrus fruit.

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