An intelligent wound dressing and a method of making the same

Abstract

The application discloses an intelligent wound dressing and a preparation method thereof, and relates to a dressing and a preparation method for closed-loop detection of wound state information and on-demand drug delivery. The application aims to overcome the problem of forming a closed-loop control of wound state monitoring and drug delivery in the existing intelligent dressing. The wound patch comprises a heating layer, an isolation layer and a patch bottom layer which are arranged in a stack from top to bottom, and a temperature and humidity sensor for collecting temperature and humidity at a wound bed; the contact surface of the heating layer and the isolation layer is provided with a liquid metal filling channel; the liquid metal filling channel is filled with liquid metal; the patch bottom layer is provided with a hydrogel through hole; the temperature and humidity signal output end of the temperature and humidity sensor is electrically connected with the temperature and humidity signal input end of a monitoring control terminal through a near field communication antenna; the liquid metal is electrically connected with a power supply through a heating switch; the monitoring control terminal acquires the temperature and humidity values at the wound bed, and generates a heating switch signal to control the closing of the heating switch and the heating of the drug hydrogel.

Description

Technical Field

[0001] This invention relates to dressings for closed-loop detection of wound condition information and on-demand drug administration, as well as their preparation methods. Background Technology

[0002] The wound healing process can be broadly divided into four phases: hemostasis, inflammation, proliferation, and remodeling. Under various conditions, wound healing can slow down or even stop, leading to chronic wounds. Therefore, timely and effective wound management is crucial for reducing infection and accelerating healing. Elevated wound temperature is considered an important indicator of wound condition, such as bacterial infection or inflammation; therefore, monitoring wound temperature can provide valuable information about the wound's status.

[0003] However, existing smart dressings only have a single temperature monitoring function or only a drug release function. They cannot obtain wound status information based on temperature monitoring and administer drugs based on the wound status, thus failing to form a closed-loop control for wound status monitoring and drug administration.

[0004] Furthermore, current smart dressing control devices are bulky, lack flexibility and human-computer interaction, and require wire connections, which affects the convenience and comfort of patients. Summary of the Invention

[0005] The purpose of this invention is to overcome the problems of closed-loop control of wound condition monitoring and drug administration in existing smart dressings, and to provide a smart wound dressing and its preparation method.

[0006] This invention provides an intelligent wound dressing, comprising a wound patch, a flexible near-field communication antenna, an medicated gel, a monitoring and control terminal, and a power supply;

[0007] The wound patch includes a heating layer, an isolation layer, and a bottom layer of the patch, which are stacked from top to bottom, as well as a temperature and humidity sensor for collecting temperature and humidity at the wound bed.

[0008] The heating layer and the insulating layer are bonded together, and the bonding surface between the two is provided with a liquid metal filling channel;

[0009] The liquid metal filling channel is filled with liquid metal;

[0010] The bottom layer of the patch has hydrogel through-holes, which are used to hold the drug hydrogel.

[0011] The temperature and humidity signal output terminal of the temperature and humidity sensor is electrically connected to the temperature and humidity signal input terminal of the monitoring and control terminal through a near-field communication antenna; the liquid metal is electrically connected to the power supply through a heating switch.

[0012] The monitoring and control terminal acquires the temperature and humidity values ​​at the wound bed from the temperature and humidity signals, and compares the temperature and humidity values ​​at the wound bed with the pre-configured temperature threshold and humidity threshold, respectively. When the temperature value at the wound bed exceeds the temperature threshold or the humidity value at the wound bed exceeds the humidity threshold, a heating switch signal is generated, and the heating switch is closed through the near-field communication antenna, so that the liquid metal generates heat to heat the hydrogel.

[0013] This invention also provides a method for preparing a smart wound dressing. Based on the above-mentioned smart wound dressing, the specific steps are as follows:

[0014] Step 1: Use soft lithography to produce the punches for the heating layer, isolation layer, exudate collection layer, and substrate bottom layer;

[0015] Step 2: Thoroughly mix the PDMS prepolymer at a ratio of 10:1 and pour it onto the punch. Then, degas it under vacuum to obtain a prefabricated device consisting of a heating layer, an insulating layer, an exudate collection layer, and a patch bottom layer. Finally, place the prefabricated device in a drying oven to cure.

[0016] Step 3: Drill holes in the cured prefabricated components according to the different designs of the heating layer, isolation layer, exudate collection layer, and patch bottom layer;

[0017] Step 4: After drilling, the prefabricated device is treated with oxygen plasma to obtain the heating layer, the isolation layer, the exudate collection layer and the patch bottom layer. Then, the heating layer, the isolation layer, the exudate collection layer, the patch bottom layer and the temperature and humidity sensor are pressed together in the top and bottom order and bonded on a hot plate.

[0018] Step 7: Inject liquid metal into the liquid metal filling channel through the connecting through-hole;

[0019] Step 9: Electrically connect the temperature and humidity sensor, liquid metal, power supply, and flexible near-field communication antenna through flexible circuits.

[0020] The beneficial effects of this invention are:

[0021] The present invention provides an intelligent wound dressing that can wirelessly monitor the temperature and humidity of the wound. It can monitor the wound condition through wound temperature and humidity monitoring, and control the liquid metal heating circuit through the monitoring and control terminal to realize the on-demand release of drugs in the hydrogel, forming a closed-loop control. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of an intelligent wound dressing according to the present invention;

[0023] Figure 2 This is a schematic diagram of the disassembled structure of a wound patch in an intelligent wound dressing according to the present invention;

[0024] Figure 3 This is a schematic diagram of the heating layer in a wound patch of an intelligent wound dressing according to the present invention;

[0025] Figure 4 This is a schematic diagram of the structure of the isolation layer in a wound patch of an intelligent wound dressing according to the present invention;

[0026] Figure 5 This is a schematic diagram of the temperature and humidity sensor in a wound patch of an intelligent wound dressing according to the present invention.

[0027] Figure 6 This is a schematic diagram of the exudate collection layer in a wound patch of a smart wound dressing according to the present invention.

[0028] Figure 7 This is a schematic diagram of the structure of the bottom layer of a wound patch in a smart wound dressing according to the present invention;

[0029] Figure 8 This is a schematic diagram of the liquid metal heating circuit in a wound patch of an intelligent wound dressing according to the present invention.

[0030] Figure 9 This is a schematic diagram illustrating the use of an intelligent wound dressing according to the present invention. Detailed Implementation

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other.

[0033] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but this is not intended to limit the scope of the invention. Specific Implementation Method 1

[0035] This embodiment of an intelligent wound dressing includes a wound patch 1, a flexible near-field communication antenna 2, an medicated gel 3, a monitoring and control terminal 4, and a power supply 5.

[0036] The wound patch 1 includes a heating layer 1-1, an isolation layer 1-2 and a patch bottom layer 1-5 stacked from top to bottom, as well as a temperature and humidity sensor 1-3 for collecting temperature and humidity at the wound bed.

[0037] The heating layer 1-1 and the isolation layer 1-2 are bonded together, and the bonding surface between the two is provided with a liquid metal filling channel 1-1-1;

[0038] Liquid metal is filled into channel 1-1-1;

[0039] The bottom layer 1-5 of the patch has hydrogel through-holes 1-5-2, which are used to carry the drug hydrogel 3.

[0040] The temperature and humidity signal output terminals of temperature and humidity sensors 1-3 are electrically connected to the temperature and humidity signal input terminals of the monitoring and control terminal 4 via the near-field communication antenna 2; the liquid metal is electrically connected to the power supply 5 via a heating switch.

[0041] The monitoring and control terminal 4 acquires the temperature and humidity values ​​at the wound bed from the temperature and humidity signals, and compares the temperature and humidity values ​​at the wound bed with the pre-configured temperature threshold and humidity threshold, respectively. When the temperature value at the wound bed exceeds the temperature threshold or the humidity value at the wound bed exceeds the humidity threshold, a heating switch signal is generated, and the heating switch is closed through the near-field communication antenna 2, so that the liquid metal generates heat to heat the hydrogel 3. Specific Implementation Method Two

[0043] This embodiment is a further explanation of embodiment one. In this embodiment, the wound patch 1 also includes an exudate collection layer 1-4; and the exudate collection layer 1-4 is disposed between the isolation layer 1-2 and the patch bottom layer 1-5.

[0044] The surface where the exudate collection layer 1-4 and the bottom layer of the patch 1-5 are bonded together is provided with an exudate storage channel 1-4-1;

[0045] The bottom layer of the patch 1-5 is provided with an exudate collection hole 1-5-3 at the position corresponding to the inlet of the exudate storage channel.

[0046] The other technical features of this embodiment are exactly the same as those of Embodiment 1. Specific Implementation Method 3

[0048] This embodiment is a further explanation of embodiment two. In this embodiment, the exudate collection layer 1-4 is provided with a hydrogel placement groove 1-4-2 on the side facing the bottom layer 1-5 of the patch.

[0049] The other technical features of this embodiment are exactly the same as those of Embodiment 2. Specific Implementation Method Four

[0051] This embodiment is a further explanation of embodiment three. In this embodiment, the temperature and humidity sensor 1-3 is in the form of a sheet and is fixed between the isolation layer 1-2 and the exudate collection layer 1-4.

[0052] Furthermore, the exudate collection layer 1-4 is provided with sensor through holes 1-4-3; the acquisition end of the temperature and humidity sensor 1-3 passes through the sensor through holes 1-4-3 and contacts the bottom layer of the patch 1-5;

[0053] Temperature and humidity acquisition holes 1-5-1 are provided on the bottom layer of the patch, corresponding to the acquisition end of the temperature and humidity sensor 1-3.

[0054] The other technical features of this embodiment are exactly the same as those of Embodiment 3. Detailed Implementation Method Five

[0056] This embodiment is a further explanation of embodiment one. In this embodiment, the isolation layer 1-2 is provided with a connecting through hole 1-2-1 that communicates with the liquid metal filling channel.

[0057] The other technical features of this embodiment are exactly the same as those of Embodiment 1. Specific Implementation Method Six

[0059] This embodiment is a further explanation of one of the embodiments one to five. In this embodiment, the heating layer 1-1, the isolation layer 1-2, the exudate collection layer 1-4, and the patch bottom layer 1-5 are all polydimethylsiloxane (PDMS) layers.

[0060] The other technical features of this embodiment are exactly the same as those of embodiments one through five. Detailed Implementation Method Seven

[0062] This embodiment is a further explanation of one of the embodiments one to five. In this embodiment, the outer surface of the patch bottom layer 1-5 is coated with pressure-sensitive adhesive.

[0063] The other technical features of this embodiment are exactly the same as those of embodiments one through five. Detailed Implementation Method Eight

[0065] This embodiment is a further explanation of one of the embodiments six. In this embodiment, the width of the liquid metal filling channel 1-1-1 is 100um and the depth is 100um.

[0066] The other technical features of this embodiment are exactly the same as those of Embodiment Six. Detailed Implementation Method Nine

[0068] This embodiment is a further explanation of one of embodiments two to five. In this embodiment, the width of the exudate storage channel 1-4-1 is 1 mm and the depth is 300 μm.

[0069] The other technical features of this embodiment are exactly the same as those of embodiments two through five. Detailed Implementation Method Ten

[0071] This embodiment of the invention provides a method for preparing an intelligent wound dressing, based on an intelligent wound dressing according to embodiment six. The specific steps are as follows:

[0072] Step 1: Use soft photolithography to produce the punches for the heating layer 1-1, the isolation layer 1-2, the exudate collection layer 1-4, and the substrate bottom layer 1-5;

[0073] Step 2: Thoroughly mix the PDMS prepolymer at a ratio of 10:1 and pour it onto the punch. Then, degas it under vacuum to obtain the prefabricated device consisting of heating layer 1-1, isolation layer 1-2, exudate collection layer 1-4, and patch bottom layer 1-5. Finally, place the prefabricated device in a drying oven to cure.

[0074] Step 3: Drill holes in the cured prefabricated components according to the different designs of heating layer 1-1, isolation layer 1-2, exudate collection layer 1-4, and patch bottom layer 1-5;

[0075] Step 4: After drilling, the prefabricated device is treated with oxygen plasma to obtain heating layer 1-1, isolation layer 1-2, exudate collection layer 1-4 and patch bottom layer 1-5 respectively. Then, heating layer 1-1, isolation layer 1-2, exudate collection layer 1-4, patch bottom layer 1-5 and temperature and humidity sensor 1-3 are pressed together in top to bottom order and bonded on a hot plate.

[0076] Step 7: Inject liquid metal into the liquid metal filling channel through the connecting through-hole 1-2-1;

[0077] Step 9: Electrically connect the temperature and humidity sensors 1-3, liquid metal, power supply 5, and flexible near-field communication antenna 2 through flexible circuits. Specific Implementation

[0079] This invention relates to an intelligent wound dressing, which comprises wound exudate management, sensor monitoring, closed-loop treatment, and a flexible circuit module, enabling effective wound exudate management and on-demand wound treatment in synergy. This integrated patch is attached to the wound site, and wound exudate is stored in microfluidic channels. It boasts advantages such as wireless connectivity, closed-loop operation, human-computer interaction, multi-functionality, flexibility, and portability.

[0080] like Figures 1 to 8 As shown, this invention is used for wound temperature and humidity monitoring and on-demand drug delivery, comprising: a wound patch 1, mainly pasted on the wound bed (wound surface) to realize wound exudate management, wound temperature and humidity information collection, and on-demand drug release functions; a flexible circuit system c (including a flexible near-field communication antenna 2), mainly used to realize sensor information processing, communication with the monitoring and control terminal 4, and drug release signal (heating switch signal) feedback functions; a power supply 5 (lithium battery) to power the entire intelligent wound dressing; and wires, mainly used to connect the power supply 5 and the flexible circuit system c.

[0081] The flexible circuit system cable connector c1 is used to connect the flexible circuit system and the wound dressing, thereby enabling power supply and signal transmission; the power interface c2 is used to connect wires; the flexible NFC antenna 23 is used to enable communication between the smart wound dressing and the monitoring and control terminal 4 (smartphone).

[0082] The wound patch includes a heating layer 1-1, an isolation layer 1-2, a temperature and humidity sensor 1-3, an exudate collection layer 1-4, and a patch bottom layer 1-5.

[0083] The heating layer 1-1 and the isolation layer 1-2 are equipped with a liquid metal filling channel 1-1-1, which is used to fill liquid metal; forming a liquid metal heating circuit 6. Heating is achieved by energizing the liquid metal heating circuit (connected to the power supply 5 through a heating switch, or by using other forms of heating circuit), thereby realizing the melting and release of the drug.

[0084] The isolation layer 1-2 is used to fix the temperature and humidity sensor 1-3; the temperature and humidity sensor 1-3 is used to monitor the temperature and humidity information of the wound.

[0085] The exudate collection layer 1-4 and the bottom layer of the patch 1-5 are equipped with an exudate storage channel 1-4-1 to store wound exudate; wound exudate b comes from the wound;

[0086] The bottom layer 1-5 of the patch serves as the base for the entire patch and the retainer for the medicated gel 3;

[0087] Drug hydrogel 3 contains temperature-sensitive hydrogel microspheres, which can achieve controlled drug release.

[0088] The heating layer 1-1 includes a PDMS substrate and liquid metal-filled grooves on the PDMS substrate. The liquid metal-filled grooves are 100µm wide, 200µm apart, and 100µm deep. The formed liquid metal-filled channels 1-1-1 are filled with liquid metal using a syringe. The liquid metal heating circuit 6 may include a circuit 6-1 formed by the liquid metal and a connection 6-2. The connection 6-2 is used to compensate for the height difference between the liquid metal heating circuit 6 and the temperature and humidity sensor 1-3, realizing the vertical connection between the two circuits.

[0089] The isolation layer 1-2 includes a PDMS film, connecting vias 1-2-1, and a sensing circuit cavity 1-2-2. Multiple connecting vias 1-2-1 (corresponding to the inlets of the liquid metal filling channels 1-1-1) are used to fill the liquid metal filling channels 1-1-1 with liquid metal and to achieve a vertical connection between the temperature and humidity sensor 1-3 and the liquid metal heating circuit. The sensing circuit cavity 1-2-2 is used to house the circuit board of the temperature and humidity sensor 1-3.

[0090] The temperature and humidity sensor 1-3 is connected to the flexible circuit system c via a flexible circuit board 1-3-1 (the flexible circuit board 1-3-1 can be external or part of the temperature and humidity sensor 1-3 itself). The temperature and humidity sensor 1-3 is used to monitor the temperature and humidity information at the wound site.

[0091] The exudate storage channel 1-4-1 includes a PDMS disc, an exudate storage groove, a hydrogel placement groove 1-4-2, and a sensor through hole 1-4-3. The exudate storage channel 1-4-1 formed by the exudate storage groove is used to store wound exudate, and its width is 1 mm and its depth is 300 μm. The hydrogel placement groove 1-4-2 is used to place the medicated hydrogel 3. The sensor through hole 1-4-3 is used to hold and fix the temperature and humidity sensor 1-3 (so that the fixed temperature and humidity sensor 1-3 passes through and is embedded). The outlet 1-4-4 of the exudate storage channel 1-4-1 is used to drain the wound exudate.

[0092] The bottom layer 1-5 of the patch includes a PDMS thin layer, a temperature and humidity acquisition hole 1-5-1, a hydrogel through-hole 1-5-2, and an exudate collection hole 1-5-3. Medical acrylic pressure-sensitive adhesive is coated on the PDMS thin layer for adhesion to the skin wound. The hydrogel through-hole 1-5-2 is used to hold and fix the medicated hydrogel 3. The PDMS thin layer forms a sensor isolation layer 1-5-4 at the position corresponding to the temperature and humidity sensor 1-3 to isolate the temperature and humidity sensor 1-3 from the wound. The sensor isolation layer 1-5-4 has a temperature and humidity acquisition hole 1-5-1 for the temperature and humidity sensor 1-3 to collect wound humidity information. The exudate collection hole 1-5-3 is used to collect wound exudate.

[0093] Drug hydrogel 3 mainly consists of poly(N-isopropylacrylamide) hydrogel microspheres and calcium alginate hydrogel, which can shrink and release drugs when heated, and is mainly used for on-demand drug release; calcium alginate hydrogel is mainly used to encapsulate hydrogel microspheres.

[0094] The main materials of the flexible circuit system c and the flexible circuit board 1-3-1 are polyimide. The main material of the wound patch 1 is PDMS. The thickness of the wound patch is 1.75mm, and the patch diameter can be selected from 10, 15, 20, 25, and 30mm according to different wound sizes.

[0095] The preparation method of the present invention includes the following steps:

[0096] Step 1: PDMS device channel fabrication uses standard soft lithography to pattern the photoresist to produce a punch.

[0097] Step 2: Then, thoroughly mix the PDMS prepolymer at a ratio of 10:1 and pour it into the mold. Place the vacuum-degassed device in an 80℃ drying oven for 2 hours to cure.

[0098] Step 3: PDMS film is produced by spin coating using a spin coater.

[0099] Step 4: Drill holes in the PDMS device using a hole punch according to the requirements and design.

[0100] Step 5: After drilling, the PDMS device is treated with oxygen plasma, and then the device is pressed together in top to bottom and placed on an 80°C hot plate for bonding for 2 hours.

[0101] Step 6: After installing the sensor, the chip is fixed by spin coating with PDMS.

[0102] Step 7: After the top liquid metal filling microchannel bonding is completed, liquid metal is injected into the channel using a syringe to form a liquid metal heating coil.

[0103] Step 8: Crosslink sodium alginate containing temperature-sensitive hydrogel microspheres using filter paper containing calcium chloride solution to form calcium alginate hydrogel.

[0104] Step 9: Connect the wound patch and lithium battery to the flexible circuit system respectively.

[0105] Step 10: Use a smartphone to monitor the temperature and humidity of the wound via NFC, and control the liquid metal heating circuit to release medication for wound treatment.

[0106] This invention relates to an intelligent wound dressing device, which comprises wound exudate management (exudate collection layer 1-4 and patch bottom layer 1-5), sensing and monitoring (temperature and humidity sensors 1-3), closed-loop monitoring and drug delivery (heating layer 1-1, isolation layer 1-2, temperature and humidity sensors 1-3, patch bottom layer 1-5), and a flexible circuit module. This device enables effective wound exudate management and on-demand wound treatment. The entire device adopts a modular design, with the wound patch 1 being a replaceable component, and the flexible circuit system c and lithium battery power supply 5 being fixed components. The three parts are connected by ribbon cable clips. The flexible circuit system c and lithium battery power supply 5 are reusable, reducing usage costs. For different wound sizes, this invention provides wound patches 1 with diameters of 10-30 mm. The medicated hydrogel 3 uses temperature-sensitive hydrogel microspheres that can be loaded with various antibiotics, sodium hyaluronate, and growth factors for the treatment of chronic wounds, offering universal applicability to different stages of wound healing. It is suitable for different wound sizes, providing a basic platform reference for the treatment of chronic wounds.

[0107] The wound exudate management module of the wound patch enables exudate storage. The sensing module simultaneously detects temperature and humidity at the wound site, providing a reference for the diagnosis of infected wounds and drug release. A liquid metal heating circuit, controlled by voltage, enables on-demand drug release from the temperature-sensitive hydrogel microspheres. The use of liquid metal as the heating circuit gives the wound patch flexibility and stretchability, enhancing wound comfort. The modular design of the wound patch reduces dressing replacement parts, lowering costs, and adapts to different wound sizes. By integrating a near-field communication antenna, the flexible circuit allows for data transmission via inductive coupling. Furthermore, the invention includes a graphical user interface mobile application for recording, analyzing, and visualizing monitoring data, while simultaneously controlling the drug release system.

[0108] like Figure 9 As shown, the intelligent wound dressing of this invention is applied to the wound site (a is the skin where the wound is located), and wound exudate is stored in the exudate storage channel 1-4-1. Simultaneously, the intelligent wound dressing can monitor the temperature and humidity of the wound to determine early infection, and uses a smartphone to control the liquid metal heating circuit to release the drug from the medicated gel 3 on demand. In a mouse model of infected wounds, the intelligent wound dressing of this invention can accelerate wound healing by reducing inflammation, promoting angiogenesis and collagen deposition. This provides a basic platform reference for the treatment of chronic wounds.

[0109] While the invention has been described herein with reference to specific embodiments, it should be understood that these embodiments are merely examples of the principles and applications of the invention. Therefore, it should be understood that many modifications can be made to the exemplary embodiments, and other arrangements can be designed without departing from the spirit and scope of the invention as defined by the appended claims. It should be understood that different dependent claims and features herein can be combined in ways different from those described in the original claims. It is also understood that features described in conjunction with individual embodiments can be used in other embodiments.

Claims

1. A smart wound dressing, characterized in that, It includes a wound patch (1), a flexible near-field communication antenna (2), a medicated hydrogel (3), a monitoring and control terminal (4), and a power supply (5); The wound patch (1) includes a heating layer (1-1), an isolation layer (1-2), and a patch bottom layer (1-5) stacked from top to bottom, as well as a temperature and humidity sensor (1-3) for collecting temperature and humidity at the wound bed. The heating layer (1-1) and the isolation layer (1-2) are bonded together, and the bonding surface of the two is provided with a liquid metal filling channel (1-1-1) formed by liquid metal filling grooves; the width of the liquid metal filling grooves is 100 μm, the spacing is 200 μm, and the depth is 100 μm; The liquid metal filling channel (1-1-1) is filled with liquid metal; The bottom layer (1-5) of the patch has hydrogel through holes (1-5-2), which are used to carry the drug hydrogel (3); the drug hydrogel (3) contains temperature-sensitive hydrogel microspheres, which can realize the controlled release of drugs; The temperature and humidity signal output terminal of the temperature and humidity sensor (1-3) is electrically connected to the temperature and humidity signal input terminal of the monitoring and control terminal (4) through the near-field communication antenna (2); the liquid metal is electrically connected to the power supply (5) through the heating switch; The monitoring and control terminal (4) acquires the temperature and humidity values ​​at the wound bed in the temperature and humidity signal, and compares the temperature and humidity values ​​at the wound bed with the pre-configured temperature threshold and humidity threshold respectively; and when the temperature value at the wound bed exceeds the temperature threshold or the humidity value at the wound bed exceeds the humidity threshold, a heating switch signal is generated, and the heating switch is closed through the near-field communication antenna (2) so that the liquid metal generates heat to heat the hydrogel (3).

2. The intelligent wound dressing according to claim 1, characterized in that, The wound patch (1) further includes an exudate collection layer (1-4); and the exudate collection layer (1-4) is disposed between the isolation layer (1-2) and the patch bottom layer (1-5); The surface where the exudate collection layer (1-4) and the bottom layer of the patch (1-5) are bonded together is provided with an exudate storage channel (1-4-1). The bottom layer of the patch (1-5) is provided with an exudate collection hole (1-5-3) at the position corresponding to the inlet of the exudate storage channel.

3. The intelligent wound dressing according to claim 2, characterized in that, The exudate collection layer (1-4) has a hydrogel placement groove (1-4-2) on the side facing the bottom layer of the patch (1-5).

4. The intelligent wound dressing according to claim 3, characterized in that, The temperature and humidity sensor (1-3) is in the form of a sheet and is fixed between the isolation layer (1-2) and the exudate collection layer (1-4); Furthermore, the exudate collection layer (1-4) is provided with a sensor through hole (1-4-3); the collection end of the temperature and humidity sensor (1-3) passes through the sensor through hole (1-4-3) and contacts the bottom layer of the patch (1-5); The bottom layer of the patch (1-5) has a temperature and humidity acquisition hole (1-5-1) at the position corresponding to the acquisition end of the temperature and humidity sensor (1-3).

5. The intelligent wound dressing according to claim 1, characterized in that, The isolation layer (1-2) is provided with a connecting through hole (1-2-1) that communicates with the liquid metal filling channel.

6. A smart wound dressing according to any one of claims 1 to 5, characterized in that, The heating layer (1-1), the isolation layer (1-2), the exudate collection layer (1-4), and the patch bottom layer (1-5) are all polydimethylsiloxane (PDMS) layers.

7. A smart wound dressing according to any one of claims 1 to 5, characterized in that, The outer surface of the patch base layer (1-5) is coated with pressure-sensitive adhesive.

8. A smart wound dressing according to any one of claims 2 to 5, characterized in that, The exudate storage channel (1-4-1) has a width of 1 mm and a depth of 300 μm.

9. A method for preparing an intelligent wound dressing, characterized in that, Based on the intelligent wound dressing according to claim 6, the specific steps are as follows: Step 1: Use soft lithography to produce the punches for the heating layer (1-1), the isolation layer (1-2), the exudate collection layer (1-4), and the substrate bottom layer (1-5); Step 2: Thoroughly mix the PDMS prepolymer at a ratio of 10:1 and pour it onto the punch. Then, degas it under vacuum to obtain a prefabricated device consisting of a heating layer (1-1), an isolation layer (1-2), an exudate collection layer (1-4), and a patch bottom layer (1-5). Finally, place the prefabricated device in a drying oven to cure. Step 3: Drill holes in the cured prefabricated device according to the different designs of the heating layer (1-1), the isolation layer (1-2), the exudate collection layer (1-4), and the patch bottom layer (1-5); Step 4: After drilling, the prefabricated device is treated with oxygen plasma to obtain the heating layer (1-1), the isolation layer (1-2), the exudate collection layer (1-4), and the patch bottom layer (1-5). Then, the heating layer (1-1), the isolation layer (1-2), the exudate collection layer (1-4), the patch bottom layer (1-5), and the temperature and humidity sensor (1-3) are pressed together in top to bottom and bonded on a hot plate. Step 7: Inject liquid metal into the liquid metal filling channel through the connecting through-hole (1-2-1); Step 9: Electrically connect the temperature and humidity sensor (1-3), liquid metal, power supply (5) and flexible near-field communication antenna (2) through flexible circuits.

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