Arrayed microcavity blood pressure detection system based on digital optical frequency double comb

Abstract

The embodiment of the application provides a kind of arrayed microcavity blood pressure detection system based on digital light frequency double comb, it is related to optical sensing technical field.The input end of light intensity modulator is connected with laser, waveform generator respectively, the output end of light intensity modulator, polarization controller, on-chip optical microcavity array are sequentially connected;Light intensity modulator is modulated based on electrical modulation signal to single-frequency light, and optical frequency double comb signal is obtained;Optical frequency double comb signal enters on-chip optical microcavity array after polarization controller, on-chip optical microcavity array is pasted to the position of the artery to be measured, and on-chip optical microcavity array includes multiple sensing units, each sensing unit generates an independent pulse signal, and on-chip optical microcavity array obtains sensing signal based on optical frequency double comb signal and the jump extrusion of the artery to be measured position, and signal processing mechanism obtains blood pressure value information based on sensing signal.The detection system can realize the technical effect of improving the accuracy and convenience of blood pressure measurement.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of optical sensing, in particular to an arrayed microcavity blood pressure detection system based on digital optical frequency double comb. BACKGROUND

[0002] Blood pressure is an important parameter index for measuring the degree of human health, because high blood pressure can cause a series of diseases such as coronary heart disease, angina pectoris, myocardial infarction and diabetes. In the treatment of high blood pressure, continuous blood pressure monitoring data has important guiding significance.

[0003] In the prior art, continuous measurement of blood pressure can only be realized by the invasive measurement method using a cannula as a standard, which uses a pressure gauge to measure the blood pressure at any arterial site. Other common methods such as Korotkoff's method, oscillographic method, etc. are discrete in time, have a long measurement time interval, and require an inflatable cuff to apply external force to assist measurement. The wave speed method for measuring blood pressure needs to set two measurement points on the body surface, and the time delay of the pulse wave at the two measurement points is measured to replace the traditional inflatable cuff for non-invasive and continuous blood pressure estimation. Generally, most of the wave speed method sets two measurement points at the heart and the wrist, and the long distance measurement has high requirements for position stability and spatial size.

[0004] The development trend of optical sensing is to require the demodulation system to have real-time detection, large multiplexing number, high precision, etc., and this correspondingly puts forward higher requirements on the laser light source used in the sensing system: high sweep rate, wide sweep range, narrow instantaneous linewidth, etc. Therefore, the current development of sensing is not only limited by the device itself but also greatly limited by the light source. The optical frequency comb is a very promising new type of light source. The general optical frequency comb is generated by a mode-locked laser, and this method has great defects in precision and speed, and cannot be flexibly adjusted. In addition, the traditional double comb needs two lasers, which greatly increases the complexity of the system. SUMMARY

[0005] The purpose of the embodiments of the present application is to provide an arrayed microcavity blood pressure detection system and method based on digital optical frequency double comb, which can realize the technical effects of improving the accuracy and convenience of blood pressure measurement.

[0006] In a first aspect, the embodiments of the present application provide an arrayed microcavity blood pressure detection system based on digital optical frequency double comb, comprising a laser, a waveform generator, an optical intensity modulator, a polarization controller, an on-chip optical microcavity array and a signal processing mechanism.

[0007] The input end of the light intensity modulator is connected with the laser and the waveform generator respectively, the output end of the light intensity modulator, the polarization controller and the on-chip optical microcavity array are sequentially connected, the laser emits single-frequency light of a preset frequency, the waveform generator generates an electrical modulation signal based on a preset time-domain signal, and the preset time-domain signal is obtained by inverse Fourier transform and superposition of two groups of frequency comb signals with a preset comb spacing and a preset frequency difference value.

[0008] The light intensity modulator modulates the single-frequency light based on the electrical modulation signal to obtain an optical frequency double-comb signal; the optical frequency double-comb signal enters the on-chip optical microcavity array after passing through the polarization controller, the on-chip optical microcavity array is attached to the position of the artery to be measured, the on-chip optical microcavity array includes a plurality of sensing units, each of which generates an independent pulse signal, the on-chip optical microcavity array obtains a sensing signal based on the optical frequency double-comb signal and the beating and extrusion of the position of the artery to be measured, and the signal processing mechanism obtains blood pressure value information based on the sensing signal.

[0009] In the implementation process, the arrayed microcavity blood pressure detection system based on digital optical frequency double-comb obtains an optical frequency double-comb signal through a laser, a waveform generator and a light intensity modulator, attaches an on-chip optical microcavity array to the position of an artery to be measured, inputs the optical frequency double-comb signal into the on-chip optical microcavity array, obtains a sensing signal under the beating and extrusion of the position of the artery to be measured, and obtains blood pressure value information based on the sensing signal; the arrayed microcavity blood pressure detection system based on digital optical frequency double-comb uses digital optical frequency double-comb as a light source, has the advantages of high bandwidth, high precision and high speed, and can freely adjust; and by using an arrayed optical microcavity, the time delay of two points can be measured in a very short distance, which improves the stability of the system and saves space size, and is more convenient; thus, the arrayed microcavity blood pressure detection system based on digital optical frequency double-comb can achieve the technical effects of improving the accuracy and convenience of blood pressure measurement.

[0010] Further, the signal processing mechanism includes an erbium-doped fiber amplifier, and the erbium-doped fiber amplifier is connected with the on-chip optical microcavity array.

[0011] In the implementation process, the signal is amplified by the erbium-doped fiber amplifier due to the certain loss of the on-chip optical microcavity array itself and the loss of the packaging coupling.

[0012] Further, the signal processing mechanism further includes a coherent receiver, and the coherent receiver is connected with the erbium-doped fiber amplifier and the laser respectively.

[0013] Further, the signal processing mechanism further includes an oscilloscope, and the oscilloscope is connected with the coherent receiver.

[0014] In the above implementation process, the amplified sensing signal enters the coherent receiver, and when the laser emits single-frequency light, the branched reference light is sent to the coherent receiver, the sensing signal and the reference light enter the coherent receiver together for demodulation, and finally the comb data is collected by the oscilloscope to restore the pulse wave waveform.

[0015] Further, the sensing signal satisfies the following relationship:

[0016]

[0017] wherein, λ is the resonant wavelength of the micro-ring resonant cavity of the on-chip optical micro-cavity array, Δ λ is the variation of the resonant wavelength, Δ l is the waveguide deformation variable, l is the total length of the original waveguide, Δ n is the waveguide refractive index variation, n is the original waveguide refractive index.

[0018] Further, the on-chip optical micro-cavity array includes two sensing units, each of which generates a set of sensing signals, and based on the two sets of sensing signals and the continuous time difference between the two sets of sensing signals, the blood pressure value information is obtained by analyzing based on the wave speed method.

[0019] Further, the to-be-measured arterial position is a radial artery position.

[0020] In a second aspect, the embodiments of the present application provide an arrayed micro-cavity blood pressure detection method based on digital optical frequency double comb, applied to the arrayed micro-cavity blood pressure detection system based on digital optical frequency double comb of any one of the first aspect, the detection method comprising:

[0021] emitting a single-frequency light of a preset frequency by a laser;

[0022] generating an electrical modulation signal based on a preset time domain signal by a waveform generator, the preset time domain signal being obtained by inverse Fourier transform and superposition of two groups of frequency comb signals with a preset comb interval and a preset frequency difference value;

[0023] modulating the single-frequency light based on the electrical modulation signal to obtain an optical frequency double comb signal;

[0024] transmitting the optical frequency double comb signal to an on-chip optical micro-cavity array to obtain a sensing signal, the on-chip optical micro-cavity array being attached to a to-be-measured arterial position;

[0025] obtaining blood pressure value information of the to-be-measured arterial position according to the sensing signal.

[0026] ​Further, before the step of generating the electrical modulation signal based on the preset time domain signal by the waveform generator, the method further comprises:

[0027] generating two groups of frequency combs with different comb intervals and having preset frequency difference values by using pseudo-random sequence codes;

[0028] converting the two groups of frequency combs into two groups of time domain signals by inverse fast Fourier transform and superimposing to obtain the preset time domain signal.

[0029] Further, after the step of obtaining the blood pressure value information of the to-be-measured arterial position according to the sensing signal, the method further comprises:

[0030] obtaining the pulse wave waveform information according to the sensing signal by frequency comb monitoring frequency shift.

[0031] Other features and advantages of the present application will be illustrated in the following description, or can be inferred from the description or determined without doubt, or can be known by implementing the above-mentioned technologies of the present application.

[0032] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the following preferred embodiments are specifically described below, and the accompanying drawings are described in detail as follows. BRIEF DESCRIPTION OF DRAWINGS

[0033] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments of the present application. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as limiting the scope. For those skilled in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0034] Figure 1 The structural schematic diagram of the arrayed microcavity blood pressure detection system based on digital optical frequency double comb provided by the embodiments of the present application;

[0035] Figure 2 The structural schematic diagram of the on-chip optical microcavity array provided by the embodiments of the present application;

[0036] Figure 3 The flowchart of the arrayed microcavity blood pressure detection method based on digital optical frequency double comb provided by the embodiments of the present application;

[0037] Figure 4 The flowchart of another arrayed microcavity blood pressure detection method based on digital optical frequency double comb provided by the embodiments of the present application;

[0038] Figure 5 The schematic diagram of the two groups of frequency combs provided by the embodiments of the present application;

[0039] Figure 6 A principle diagram of frequency comb demodulation provided for an embodiment of the present application is shown in the following figure;

[0040] Figure 7 A diagram of long-time stable measurement data provided for an embodiment of the present application is shown in the following figure;

[0041] Figure 8 A diagram of time difference of two groups of pulse waves provided for an embodiment of the present application is shown in the following figure;

[0042] Figure 9 A diagram of detection of blood pressure value information-time provided for an embodiment of the present application is shown in the following figure.

[0043] Figure: laser 100; waveform generator 200; optical intensity modulator 300; polarization controller 400; on-chip optical microcavity array 500; sensing unit 510; optical fiber 520; signal processing mechanism 600; erbium-doped fiber amplifier 610; coherent receiver 620; oscilloscope 630. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. The components of the embodiments of the present application described and shown in the drawings herein can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed present application, but only represents selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application.

[0045] In the present application, the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. These terms are mainly used to better describe the present application and its embodiments, and are not intended to limit the indicated devices, elements or components to have a specific orientation, or to be constructed and operated in a specific orientation.

[0046] In addition, in addition to being used to indicate the orientation or positional relationship, the above-mentioned partial terms can also be used to indicate other meanings, for example, the term "upper" can also be used to indicate a certain dependent relationship or connection relationship in some cases. Those skilled in the art can understand the specific meaning of these terms in the present application according to the specific situation.

[0047] In addition, the terms "mounting", "arrangement", "provided with", "connected", "linked" should be interpreted broadly. For example, it can be fixed connection, detachable connection, or integral structure; it can be mechanical connection, or point connection; it can be direct connection, or indirect connection through intermediate medium, or internal connection between two devices, elements or components. The specific meaning of the above terms in the present application can be understood by those skilled in the art according to the specific circumstances.

[0048] In addition, the terms "first", "second", etc. are mainly used to distinguish different devices, elements or components (the specific type and structure may be the same or different), and are not intended to indicate or imply the relative importance and quantity of the indicated devices, elements or components. Unless otherwise stated, the meaning of "multiple" is two or more.

[0049] The embodiment of the present application is based on a digital optical frequency double comb arrayed microcavity blood pressure detection system and method, which can be applied to continuous blood pressure monitoring. The digital optical frequency double comb arrayed microcavity blood pressure detection system obtains an optical frequency double comb signal through a laser, a waveform generator and an optical intensity modulator, attaches an on-chip optical microcavity array to the position to be measured, and inputs the optical frequency double comb signal to the on-chip optical microcavity array to obtain a sensing signal under the pulsation compression at the position to be measured. The blood pressure value information is obtained based on the sensing signal. The digital optical frequency double comb arrayed microcavity blood pressure detection system uses a digital optical frequency double comb as a light source, has the advantages of high bandwidth, high precision and high speed, and can be freely adjusted. By using an arrayed optical microcavity, the time delay of two points can be measured in a very short distance, which improves the system stability and saves space size, and is more convenient. Therefore, the digital optical frequency double comb arrayed microcavity blood pressure detection system can realize the technical effects of improving the accuracy and convenience of blood pressure measurement.

[0050] In recent years, with the rapid development of on-chip optical technology, light source technology and optical information processing, it is possible to realize higher quality sensing and detection in the field of biological medicine and other fields by using more sensitive and faster optical methods. The high integration, easy arraying characteristics of optical microcavities and the high flexibility of digital optical frequency comb are combined, which realizes a more accurate and more convenient blood pressure measurement compared with various traditional blood pressure detection methods.

[0051] Please refer to Figure 1 and Figure 2 , Figure 1 The structure diagram of the digital optical frequency double comb arrayed microcavity blood pressure detection system provided by the embodiment of the present application is shown in Figure 2A structure diagram of an on-chip optical microcavity array provided by an embodiment of the present application; the arrayed microcavity blood pressure detection system based on a digital optical frequency double comb includes a laser 100, a waveform generator 200, an optical intensity modulator 300, a polarization controller 400, an on-chip optical microcavity array 500, and a signal processing mechanism 600;

[0052] Illustratively, the input ends of the optical intensity modulator 300 are connected with the laser 100 and the waveform generator 200 respectively, the output end of the optical intensity modulator 300, the polarization controller 400, and the on-chip optical microcavity array 500 are connected in sequence, the laser 100 emits single-frequency light of a preset frequency, the waveform generator 200 generates an electrical modulation signal based on a preset time-domain signal, and the preset time-domain signal is obtained by inverse Fourier transform and superposition of two groups of frequency comb signals with a preset comb interval and a preset frequency difference.

[0053] Illustratively, the optical intensity modulator 300 modulates the single-frequency light based on the electrical modulation signal to obtain an optical frequency double comb signal; the optical frequency double comb signal enters the on-chip optical microcavity array 500 after passing through the polarization controller 400, the on-chip optical microcavity array 500 is attached to the position of the artery to be measured, the on-chip optical microcavity array 500 includes a plurality of sensing units, each sensing unit generates an independent pulse signal, the on-chip optical microcavity array 500 obtains a sensing signal based on the optical frequency double comb signal and the pulsation compression of the position of the artery to be measured, and the signal processing mechanism 600 obtains blood pressure value information based on the sensing signal.

[0054] Illustratively, the signal processing mechanism 600 includes an erbium-doped fiber amplifier 610, and the erbium-doped fiber amplifier 610 is connected with the on-chip optical microcavity array 500.

[0055] Illustratively, the signal is amplified by the erbium-doped fiber amplifier due to the certain loss of the on-chip optical microcavity array 500 itself plus the loss of the packaging coupling.

[0056] Illustratively, the signal processing mechanism 600 further includes a coherent receiver 620, and the coherent receiver 620 is connected with the erbium-doped fiber amplifier 610 and the laser 100 respectively.

[0057] Illustratively, the signal processing mechanism 600 further includes an oscilloscope 630, and the oscilloscope is connected with the coherent receiver 620.

[0058] Illustratively, the amplified sensing signal enters the coherent receiver 620, and the laser 100 sends the split reference light to the coherent receiver 620 when emitting the single-frequency light, the sensing signal and the reference light enter the coherent receiver 620 together for demodulation, and finally the frequency comb data is collected by the oscilloscope 630 to restore the pulse wave form.

[0059] Illustratively, the sensing signal satisfies the following relationship:

[0060] ;

[0061] wherein, λ is a resonant wavelength of a micro-ring resonant cavity of the on-chip optical microcavity array, Δ λ is a variation amount of the resonant wavelength, Δ l is a waveguide deformation variable, l is a total length of the original waveguide, Δ n is a waveguide refractive index variation amount, n is an original waveguide refractive index.

[0062] Exemplarily, the on-chip optical microcavity array 500 includes two sensing units 510, each of which generates a set of sensing signals, and based on the two sets of sensing signals and the continuous time difference between the two sets of sensing signals, the blood pressure value information is obtained by analyzing based on the wave speed method; optionally, the two ends of the on-chip optical microcavity array 500 are respectively connected with corresponding optical fibers 520.

[0063] Exemplarily, the to-be-measured arterial position is a radial arterial position.

[0064] Please refer to Figure 3 , Figure 3 is a flowchart of an arrayed microcavity blood pressure detection method based on a digital optical frequency double comb provided by an embodiment of the present application, applied to Figure 1 and Figure 2 a digital optical frequency double comb-based arrayed microcavity blood pressure detection system, the detection method comprising the following steps:

[0065] S100: emitting a single-frequency light of a preset frequency by a laser;

[0066] S200: generating an electrical modulation signal based on a preset time-domain signal by a waveform generator, the preset time-domain signal being obtained by inversely transforming and superimposing two groups of frequency comb signals having a preset comb interval and a preset frequency difference value;

[0067] S300: modulating the single-frequency light based on the electrical modulation signal to obtain an optical frequency double comb signal;

[0068] S400: transmitting the optical frequency double comb signal to an on-chip optical microcavity array to obtain a sensing signal, the on-chip optical microcavity array being attached to a to-be-measured arterial position;

[0069] S500: obtaining blood pressure value information of the to-be-measured arterial position according to the sensing signal.

[0070] Please refer to Figure 4 , Figure 4 is a flowchart of another arrayed microcavity blood pressure detection method based on a digital optical frequency double comb provided by an embodiment of the present application.

[0071] For example, prior to step S200: generating an electrically modulated signal based on a preset time-domain signal using a waveform generator, the method further includes:

[0072] S110: Generate two sets of frequency combs with different comb tooth intervals and preset frequency differences using pseudo-random sequence codes;

[0073] S120: The two sets of frequency combs are converted into two sets of time-domain signals by inverse fast Fourier transform and then superimposed to obtain a preset time-domain signal.

[0074] For example, after step S500: obtaining blood pressure information of the location of the artery to be measured based on the sensing signal, the method further includes:

[0075] S600: Obtain pulse wave waveform information by monitoring frequency shift through frequency comb based on sensor signals.

[0076] In some embodiments, the arrayed microcavity blood pressure detection system based on digital optical frequency dual comb provided in this application can use an on-chip optical microcavity array to measure pulse waves at two locations on the radial artery in parallel. Since general single-wavelength lasers cannot meet the requirements of arrayed detection, a high-bandwidth, high-precision, high-speed, and freely adjustable digital optical frequency dual comb is introduced for detection and demodulation. By acquiring the pulse wave signal, the time delay of the pulse waves at two relatively close different locations is extracted, and combined with the mathematical model of time difference to blood pressure, more accurate systolic and diastolic blood pressure can be obtained. Thus, this arrayed microcavity blood pressure detection system based on digital optical frequency dual comb improves the problems of discontinuity in current blood pressure measurement and the instability and poor convenience of the traditional wave velocity method.

[0077] In some implementations, combined Figures 1 to 4 The specific working process of the arrayed microcavity blood pressure detection method based on digital optical frequency dual comb provided in this application is illustrated below:

[0078] The laser emits a frequency of f 0-frequency light enters the light intensity modulator for modulation;

[0079] The computer generates two sets of frequency combs with a bandwidth of 2GHz and comb spacings of 3.920MHz and 3.913MHz respectively (frequency difference approximately 7kHz) using pseudo-random sequence codes. Figure 5 As shown, Figure 5 A schematic diagram of two sets of frequency comb teeth provided in an embodiment of this application;

[0080] For example, Figure 5 The figure shows a schematic diagram of the increasing frequency difference between the two sets of comb teeth in the simulated frequency domain.

[0081] The two groups of frequency combs (frequency domain signals) are converted into time domain signals by inverse fast Fourier transform and are superimposed to generate a preset time domain signal, and then the code of the generated preset time domain signal is imported into a 60GS / s signal generator to generate an electrical signal consistent with the code, which is used as a modulation signal of an optical intensity modulator to modulate the signal light branched from a laser;

[0082] The optical frequency double comb signal (optical signal) after the optical intensity modulator is a series of optical frequency combs consistent with the previous design in the frequency domain, and the double combs are frequency modulated at the demodulation end to reduce the bandwidth requirement of the demodulation end, improve the sampling rate, and improve the time resolution of the pulse detection;

[0083] The optical frequency double comb signal passes through the polarization controller and directly enters the on-chip optical microcavity array, and each sensing unit in the array can generate an independent pulse signal. The on-chip optical microcavity array is in line with the trend of the radial artery, and the radial artery pulsation causes extrusion to the on-chip optical microcavity array. The microcavity of the on-chip optical microcavity array is deformed under stress, resulting in a change in refractive index and a shift in the resonance peak. According to the micro-ring resonance formula 2πnR = mλ, the following relationship can be derived:

[0084] ;

[0085] wherein, λ is the resonance wavelength of the micro-ring resonant cavity, Δ λ is the change amount of the resonance wavelength, Δ l is the waveguide deformation amount, l is the total length of the original waveguide, Δ n is the waveguide refractive index change amount, n is the original waveguide refractive index;

[0086] The pulse waveform is restored by the frequency comb monitoring frequency shift method, as shown in Figure 6 , which is a schematic diagram of the frequency comb demodulation provided by the embodiment of the application; Figure 6 Exemplarily,

[0087] as shown, the ordinate is the collected single-frame double-comb frequency domain image after frequency domain image, and the amplitude information of the pulse wave at this moment is read out according to the resonance peak depression in the frequency domain (the amplitude intensity corresponds to the resonance peak shift amount), and the comb interval is the longitudinal resolution of the pulse wave; the abscissa is the continuous pulse information under continuous long-time sampling, and the sampling rate of each frame of spectrum image is the transverse resolution of the pulse wave. The thick solid line is the restored pulse wave signal; Figure 6

[0088] ​Because the sensing units of the on-chip optical microcavity array (taking two sensing units as an example) are placed in sequence, and each sensing unit generates a group of sensing signals, therefore the two groups of sensing signals will have a corresponding time difference, based on the principle of wave speed method, the continuous time difference is analyzed, and the blood pressure value is obtained by substituting the wave speed-blood pressure model formula;

[0089] Because the chip itself has a certain loss plus the loss of packaging coupling, so subsequent amplification is needed through an erbium-doped optical fiber amplifier; the amplified optical signal and the previously branched reference light enter the coherent receiver for demodulation together, and finally the frequency comb data is collected by an oscilloscope to restore the waveform, the principle is shown in Figure 7 and Figure 8 , Figure 7 a schematic diagram of long-time stable measurement data provided by the embodiment of the present application, Figure 8 a schematic diagram of the time difference of two groups of pulse waves provided by the embodiment of the present application.

[0090] Exemplarily, the pulse wave wave speed method is based on the Moens-Korteweg equation to give the relationship between the pulse wave wave speed PWV and the arterial wall elastic modulus E in , the expression is:

[0091] ;

[0092] Among them, h is the thickness of the arterial wall, ρ is the density of blood, r is the radius of the artery. The arterial wall elastic modulus E in is directly related to blood pressure, the relationship is:

[0093] ;

[0094] Among them, P is the mean blood pressure (Mean Blood Pressure, MBP); because:

[0095] ;

[0096] Further combined with the Bramwell-Hill formula, the values of systolic blood pressure (Systolic Blood Pressure, SBP) and diastolic blood pressure (Diastolic Blood Pressure, DBP) can be further obtained:

[0097] ;

[0098] ;

[0099] Wherein, PTT is the propagation time, A is the empirical mean of individual-specific difference which can be obtained by a large amount of data analysis, SBP0, DBP0 and PTT0 are the preset initial values of the systolic pressure, diastolic pressure and propagation time respectively, which can also be calibrated together with other initial values. Thus, as long as the time difference between each two points is identified by the frequency comb method, the continuous non-invasive measurement of blood pressure can be realized, Figure 9 The average value of blood pressure in 10s every 1 hour is shown.

[0100] In some implementation scenarios, it is found through actual experiments that the on-chip optical microcavity combined with the digital optical frequency double comb system in the embodiments of the present application can accurately detect the pulse, accurately identify the characteristic parameter points of the main wave, re-beat wave and descending middle isthmus of the pulse wave and the time delay of the two groups of data. The use of the digital optical frequency comb system makes the arrayed pulse detection more convenient. At the same time, through the derivation of the above formula, the accurate pulse systolic pressure and diastolic pressure can be obtained, which is a more accurate and convenient optical arrayed blood pressure measurement method.

[0101] In all embodiments of the present application, "large", "small" are relative, "more", "less" are relative, "upper", "lower" are relative, and the present embodiments will not be described further for such relative expressions.

[0102] It should be understood that the "in the present embodiment", "in the present embodiment" or "as an optional implementation" mentioned throughout the specification means that the specific features, structures or characteristics related to the embodiments are included in at least one embodiment of the present application. Therefore, "in the present embodiment", "in the present embodiment" or "as an optional implementation" appearing throughout the specification does not necessarily refer to the same embodiment. In addition, these specific features, structures or characteristics can be combined in one or more embodiments in any suitable manner. Those skilled in the art should also know that the embodiments described in the specification are optional embodiments, and the actions and modules involved are not necessarily required by the present application.

[0103] In various embodiments of the present application, it should be understood that the size of the serial number of the above processes does not mean the inevitable sequence of execution, and the execution sequence of each process should be determined according to its function and inherent logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0104] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can easily think of changes or replacements within the technical scope disclosed in the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. An arrayed microcavity blood pressure detection system based on digital optical frequency dual combs, characterized in that, It includes lasers, waveform generators, light intensity modulators, polarization controllers, on-chip optical microcavity arrays, and signal processing mechanisms; The input terminal of the light intensity modulator is connected to the laser and the waveform generator respectively. The output terminal of the light intensity modulator, the polarization controller, and the on-chip optical microcavity array are connected in sequence. The laser emits single-frequency light of a preset frequency. The waveform generator generates an electrical modulation signal based on a preset time domain signal. The preset time domain signal is obtained by performing an inverse Fourier transform and superimposing two sets of frequency comb signals with a preset comb tooth interval and a preset frequency difference. The light intensity modulator modulates the single-frequency light based on the electrical modulation signal to obtain an optical frequency dual-comb signal; the optical frequency dual-comb signal enters the on-chip optical microcavity array after passing through the polarization controller; the on-chip optical microcavity array is attached to the location of the artery to be measured; the on-chip optical microcavity array includes two sensing units, each of which generates an independent pulse signal; the on-chip optical microcavity array obtains a sensing signal based on the optical frequency dual-comb signal and the pulsation and compression of the location of the artery to be measured; and the signal processing mechanism obtains blood pressure information based on the sensing signal. The sensing signals satisfy the following relationship: Wherein, λ is the resonant wavelength of the micro-ring resonant cavity of the on-chip optical microcavity array, Δλ is the change in resonant wavelength, Δl is the waveguide deformation, l is the total length of the original waveguide, Δn is the change in waveguide refractive index, and n is the original waveguide refractive index. Each sensing unit generates a set of sensing signals. Based on the two sets of sensing signals and the continuous time difference between the two sets of sensing signals, the blood pressure information is obtained by analyzing the wave velocity method.

2. The arrayed microcavity blood pressure detection system based on digital optical frequency dual combs according to claim 1, characterized in that, The signal processing mechanism includes an erbium-doped fiber amplifier, which is connected to the on-chip optical microcavity array.

3. The arrayed microcavity blood pressure detection system based on digital optical frequency dual combs according to claim 2, characterized in that, The signal processing mechanism further includes a coherent receiver, which is connected to the erbium-doped fiber amplifier and the laser, respectively.

4. The arrayed microcavity blood pressure detection system based on digital optical frequency dual combs according to claim 3, characterized in that, The signal processing mechanism also includes an oscilloscope, which is connected to the coherent receiver.

5. The arrayed microcavity blood pressure detection system based on digital optical frequency dual combs according to claim 1, characterized in that, The location of the artery to be tested is the radial artery.

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