A composition with instant soothing efficacy, and its preparation method and application

Abstract

The application belongs to the technical field of cosmetics, and discloses a composition with instant soothing effect, a preparation method and application thereof. The composition comprises components: hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, and edelweiss callus extract. The composition has significant soothing effect and can instantly soothe, thereby instantly relieving the uncomfortable feeling such as stinging, burning, swelling and itching, through reasonable compounding of hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, and edelweiss callus extract.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a composition with instant soothing effect and a preparation method and application thereof. BACKGROUND

[0002] Sensitive skin refers to a high reaction state occurring under physiological or pathological conditions, and is clinically manifested as subjective feelings such as burning, stinging and itching of the skin when stimulated by physical, chemical, mental and other factors, and is also manifested as objective signs such as erythema and scales. According to epidemiological studies, more than 30% of the world's population has sensitive skin symptoms.

[0003] Allergic skin causes consumers to have an excessive reaction or intolerance to external stimuli. In most cases, these stimuli symptoms include stinging, burning, redness, itching and the like, which are the pain points of consumers with allergic skin and are problems that need to be solved urgently by sensitive skin care products.

[0004] At present, the products on the market for soothing sensitive skin mainly achieve the effect through two ways: one is to achieve soothing effect by moisturizing and increasing the water content of the skin, but only by increasing the water content of the skin to achieve soothing effect, which is a temporary solution. If the water content of the skin decreases, discomfort will still occur. The other is to resist external stimuli by long-term barrier repair, such as the invention patent with the publication number CN112137931A discloses a composition for soothing sensitive skin with high efficiency, which can improve the tolerance of the skin after 28 days of use. However, the physiological repair cycle of the skin requires more than 28 days, which cannot meet the instant soothing needs of sensitive skin in a high reaction state. It can be seen that the above two ways cannot instantaneously soothe the high reaction state of sensitive skin and solve the discomfort such as stinging, burning, redness and itching of sensitive skin.

[0005] Therefore, it is a technical problem that needs to be solved by those skilled in the art to develop a product that can instantaneously soothe sensitive skin and relieve discomfort such as stinging, burning, redness and itching. SUMMARY

[0006] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides a composition which can instantaneously soothe sensitive skin and instantaneously relieve discomfort such as stinging, burning, redness and itching.

[0007] The first aspect of the present application provides a composition comprising the following components: hydroxyphenylpropionamide benzoic acid and / or mother of the chrysanthemum flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, high mountain fireweed callus extract.

[0008] During long-term production research, the inventors have dug into effective ingredients in cosmetic raw materials for calming, relieving itching, relieving pain, and removing redness, such as acetyl dipeptide-1 cetyl ester, 4-tert-butylcyclohexanol, beta-glucan, dipotassium glycyrrhizate, aloe extract, Astragalus membranaceus root extract, Saposhnikovia divaricata root extract, Calendula officinalis flower extract, Albizia julibrissin flower extract, Gastrodia elata root extract, Ophiopogon japonicus extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea extract, Glycyrrhiza glabra root extract, Matricaria chamomilla flower extract, Rosmarinus officinalis leaf extract, Polygonum hydropiper extract, Sophora flavescens root extract, Tribulus terrestris fruit extract, and Cornus officinalis fruit extract, and unexpectedly found that the combination of hydroxyphenylpropionamide benzoic acid and / or Matricaria chamomilla flower oil, farnesol and / or hydroxyasiatic acid glycoside, Kava leaf / root / stem extract and / or menthol lactate, and Ledum palustre callus extract has significant soothing effect and can instantly soothe, thereby instantly relieving the discomfort such as stinging, burning, swelling, and itching.

[0009] Specifically, in the composition of the present application, the effects of each component are as follows:

[0010] Hydroxyphenylpropionamide benzoic acid or Matricaria chamomilla flower oil can inhibit the release of histamine from mast cells, prevent the binding of P substance released by nerve endings to NK-1 receptors of mast cells, and relieve itching and swelling.

[0011] Farnesol or hydroxyasiatic acid glycoside can regulate the release and expression of various cytokines such as IL-1α, TNF-α, IL-6, IL-8, INOS, and COX-2, thereby inhibiting inflammatory factors from the source, inhibiting vasodilation, and inhibiting redness and erythema.

[0012] The piperine ingredients contained in Kava leaf / root / stem extract not only have a slight anesthetic analgesic effect, but also can effectively inhibit the overexpression of TRPV1 and release of neurotransmitters, effectively inhibit the burning and pain; menthol lactate is a mild TRPM8 activator, which acts on sensory nerve endings to reduce pain and give the skin a cooling sensation.

[0013] Ledum palustre callus has active ingredients different from those of the plant, and has stronger activity, excellent antioxidant and DNA protection performance, and greatly improves the self-repairing ability of skin cells after external stimulation.

[0014] According to some embodiments of the present application, the composition comprises the following components in mass parts: hydroxyphenylpropionamide benzoic acid and / or Matricaria chamomilla flower oil 1-30 parts, farnesol and / or hydroxyasiatic acid glycoside 10-70 parts, Kava leaf / root / stem extract and / or menthol lactate 1-30 parts, and Ledum palustre callus extract 10-70 parts.

[0015] According to some embodiments of the present application, the composition comprises the following components in mass fraction: 1-20 parts of hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, 20-60 parts of farnesol and / or hydroxy asperosaponin, 1-20 parts of kava pepper leaf / root / stem extract and / or menthol lactate, 20-70 parts of high mountain firebush callus extract.

[0016] According to some embodiments of the present application, the composition comprises the following components in mass fraction: 1-10 parts of hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, 30-50 parts of farnesol and / or hydroxy asperosaponin, 5-15 parts of kava pepper leaf / root / stem extract and / or menthol lactate, 50-70 parts of high mountain firebush callus extract.

[0017] The second aspect of the present application provides a preparation method of the composition of the present application, comprising the following steps:

[0018] The components are mixed to obtain the composition.

[0019] The third aspect of the present application provides a cosmetic product comprising the composition of the present application.

[0020] According to some embodiments of the present application, the cosmetic product comprises a facial cleanser, a cosmetic water, a lotion, a foundation, a mask or a body lotion.

[0021] According to some embodiments of the present application, the cosmetic product further comprises a cosmetically acceptable adjuvant.

[0022] According to some embodiments of the present application, the adjuvant comprises at least one of an oil, an emulsifier, a polyol, a thickening agent.

[0023] According to some embodiments of the present application, the composition is added to the cosmetic product in an amount of 0.05-5wt%.

[0024] According to some embodiments of the present application, the composition is added to the cosmetic product in an amount of 0.5-2wt%.

[0025] The fourth aspect of the present application provides a face cream comprising the composition of the present application.

[0026] According to some embodiments of the present application, the face cream further comprises the following components: glycerin, 1,3-propanediol, 1,2-hexanediol, p-hydroxyacetophenone, ceteth-10 / 1 PEG / PPG dimethicone, hydrogenated polyisobutene, dimethicone, shea butter, polyglyceryl-4 isostearate, trihydroxystearin.

[0027] Compared with the prior art, the present application has the following advantages:

[0028] The composition of the present application reasonably matches hydroxyphenylpropionamide benzoic acid and / or mother chamomile flower oil, farnesol and / or hydroxyl asperosaponin, kava pepper leaf / root / stem extract and / or menthol lactate, high mountain fireweed callus extract, has significant soothing effect, can quickly solve various uncomfortable feelings of the skin, can also avoid secondary damage caused by scratching and rubbing, and greatly relieves unpleasant feelings caused by sensitive skin. BRIEF DESCRIPTION OF DRAWINGS

[0029] The present application will be further described below in combination with the drawings and examples.

[0030] Figure 1 The erythema comparison chart after 2h for the samples of application example 1 and comparative application example 19 respectively. DETAILED DESCRIPTION

[0031] In order to make those skilled in the art more clearly understand the technical solutions of the present application, the following examples are listed for illustration. It should be pointed out that the following examples do not constitute a limitation on the scope of protection required by the present application.

[0032] The raw materials, reagents or devices used in the following examples, if not specifically stated, can be obtained from conventional commercial channels or can be obtained by existing known methods.

[0033] Example 1

[0034] The present example provides a composition with instant soothing effect, which is composed of the following components in mass fraction: hydroxyphenylpropionamide benzoic acid 2 parts, mother chamomile flower oil 1 part, farnesol 20 parts, hydroxyl asperosaponin 15 parts, kava pepper leaf / root / stem extract 4 parts, menthol lactate 5 parts, and high mountain fireweed callus extract 53 parts.

[0035] The preparation method of the composition with instant soothing effect in the present example is to mix the components uniformly.

[0036] Example 2

[0037] The present example provides a composition with instant soothing effect, which is composed of the following components in mass fraction: hydroxyphenylpropionamide benzoic acid 3 parts, farnesol 20 parts, hydroxyl asperosaponin 15 parts, kava pepper leaf / root / stem extract 10 parts, and high mountain fireweed callus extract 52 parts.

[0038] The preparation method of the composition with instant soothing effect in the present example is to mix the components uniformly.

[0039] Example 3

[0040] This embodiment provides a composition with immediate soothing effects, which consists of the following components in parts by weight: 2 parts of chamomile oil, 20 parts of bisabolol, 18 parts of asiaticoside, 7 parts of menthol lactate, and 53 parts of Edelweiss callus extract.

[0041] The method for preparing the composition with immediate soothing effect in this embodiment is as follows: simply mix all components evenly.

[0042] Comparative Example 1

[0043] Compared with Example 1, Comparative Example 1 contains only hydroxyphenylpropionamide benzoic acid and chamomile oil, and the amount of components is the same as in Example 1.

[0044] Comparative Example 2

[0045] Compared with Example 1, Comparative Example 2 contains only bisabolol and asiaticoside, and the amount of components is the same as in Example 1.

[0046] Comparative Example 3

[0047] Compared to Example 1, Comparative Example 3 contained only kava leaf / root / stem extract and menthol lactate, with the same component amounts as in Example 1.

[0048] Comparative Example 4

[0049] Compared with Example 1, Comparative Example 4 contained only Edelweiss callus extract, and the amount of components was the same as in Example 1.

[0050] Comparative Example 5

[0051] Compared with Example 1, Comparative Example 5 contains only hydroxyphenylpropionamide benzoic acid, chamomile oil, bisabolol and asiaticoside, and the amounts of the components are the same as in Example 1.

[0052] Comparative Example 6

[0053] Compared with Example 1, Comparative Example 6 contains only hydroxyphenylpropionamide benzoic acid, chamomile oil, kava leaf / root / stem extract and menthol lactate, and the amounts of the components are the same as in Example 1.

[0054] Comparative Example 7

[0055] Compared with Example 1, Comparative Example 7 contained only hydroxyphenylpropionamide benzoic acid, chamomile oil and edelweiss callus extract, and the amounts of the components were the same as in Example 1.

[0056] Comparative Example 8

[0057] Compared with Example 1, Comparative Example 8 contains only bisabolol, asiaticoside, kava leaf / root / stem extract and menthol lactate, and the amounts of the components are the same as in Example 1.

[0058] Comparative Example 9

[0059] Compared with Example 1, Comparative Example 9 contained only bisabolol, asiaticoside and Edelweiss callus extract, and the amounts of the components were the same as in Example 1.

[0060] Comparative Example 10

[0061] Compared with Example 1, Comparative Example 10 contained only Kava leaf / root / stem extract, menthol lactate and Edelweiss callus extract, with the same amount of components as in Example 1.

[0062] Comparative Example 11

[0063] Compared with Example 1, Comparative Example 11 lacked the Edelweiss callus extract, while the other components and amounts were the same as in Example 1.

[0064] Comparative Example 12

[0065] Compared with Example 1, Comparative Example 12 lacked kava leaf / root / stem extract and menthol lactate, while other components and amounts were the same as in Example 1.

[0066] Comparative Example 13

[0067] Compared with Example 1, Comparative Example 13 lacked bisabolol and asiaticoside, while the other components and amounts were the same as in Example 1.

[0068] Comparative Example 14

[0069] Compared with Example 1, Comparative Example 14 lacked hydroxyphenylpropionamide benzoic acid and chamomile oil, while the other components and amounts were the same as in Example 1.

[0070] Comparative Example 15

[0071] Compared with Example 1, in Comparative Example 15, hydroxyphenylpropionamide benzoic acid and chamomile oil were replaced with β-glucan, while other components and amounts were the same as in Example 1.

[0072] Comparative Example 16

[0073] Compared with Example 1, in Comparative Example 16, bisabolol and asiaticoside were replaced with dipotassium glycyrrhizate, while the other components and amounts were the same as in Example 1.

[0074] Comparative Example 17

[0075] Compared with Example 1, in Comparative Example 17, the leaf / root / stem extract of Peppermint and menthol lactate were replaced with 4-tert-butylcyclohexanol, while the other components and amounts were the same as in Example 1.

[0076] Comparative Example 18

[0077] Compared with Example 1, in Comparative Example 18, the Edelweiss callus extract was replaced with aloe vera extract, while the other components and amounts were the same as in Example 1.

[0078] Application Example 1

[0079] This application example provides a face cream, the formula of which is shown in Table 1.

[0080] Table 1

[0081]

[0082]

[0083] The preparation method of this face cream includes the following steps:

[0084] 1) Add phase A to the aqueous phase pot and stir at 85°C until completely dissolved to obtain the aqueous phase;

[0085] 2) Add phase B to the oil phase pot and stir at 85°C until completely dissolved. Then slowly pump the aqueous phase from step 1) into the oil phase pot and homogenize and emulsify at 6000 rpm for 15 minutes to obtain the mixture.

[0086] 3) After the mixture from step 2) has cooled to 60°C, add the C phase component, stir until evenly dispersed, cool to below 40°C, filter through a 200-mesh filter, and the face cream is obtained.

[0087] Application Example 2-3

[0088] Compared with Application Example 1, in Application Examples 2-3, the composition provided in Example 1 was replaced with the composition provided in Example 2-3, and the other components, dosages and preparation methods were the same as in Application Example 1.

[0089] Compare and contrast with example 1-18

[0090] Compared with Application Example 1, in Comparative Application Examples 1-18, the composition provided in Example 1 was replaced with the substance provided in Comparative Examples 1-18, and the other components, amounts and preparation methods were the same as in Application Example 1.

[0091] Comparative Application Example 19

[0092] Compared with Application Example 1, in Comparative Application Example 19, the composition provided in Example 1 was replaced with deionized water, while the other components, amounts, and preparation methods were the same as in Application Example 1.

[0093] Experimental Example 1: Capsaicin Stimulation Sensory Test

[0094] 1.1 Experimental Principle

[0095] Capsaicin is the active ingredient in chili peppers. Upon contact with the human body, capsaicin activates the TRPV1 sensory receptor, producing burning, stinging, and other uncomfortable sensations. Based on this principle, a capsaicin receptor stimulation model was established, and the soothing and sedative effects of the tested and comparative examples were evaluated using topical samples.

[0096] 1.2 Experimental Methods

[0097] Thirty-three subjects, aged 25–50 years, were randomly selected. Two 1cm × 1cm test sites were chosen on each of their left and right upper arms. 1cm × 1cm filter paper was soaked in a 10% capsaicin solution and then applied to the test sites for 30 minutes. After 30 minutes, the filter paper was removed, and the test sample was immediately applied. One test site was randomly selected for application example 19, while the remaining test sites were randomly selected for application examples 1–3 and application examples 1–18. Pain and burning sensations were observed within 30 minutes, and scores were given based on the perceived sensations.

[0098] Scoring criteria: -1 point - Increased discomfort; 0 points - No relief; 1 point - Slight relief; 2 points - Some relief; 3 points - Significant relief.

[0099] 1.3 Experimental Results

[0100] The results are shown in Table 2, and the scores are based on the average score.

[0101] Table 2

[0102]

[0103]

[0104] As can be seen from the data in Table 2, various soothing ingredients have a certain effect on suppressing burning and pain. However, the combination method of the present invention has significant immediate pain relief and soothing effect on burning sensation, and the soothing effect can last for more than two hours. The soothing effect of the composition of the present invention is significantly better than that of the various comparative application examples.

[0105] Experimental Example 2: Redness Suppression Test

[0106] 2.1 Experimental Principle

[0107] Multiple pro-inflammatory factors are involved in the inflammatory response, which not only exacerbate allergic reactions but also dilate blood vessels, leading to increased skin erythema and inflammation. The industry uses the α-value to represent changes in skin hemoglobin or erythema levels. Based on this principle, a capsaicin receptor stimulation model was established, and the redness-reducing efficacy of the tested and comparative examples was evaluated using topical samples.

[0108] 2.2 Experimental Methods

[0109] The experimental method was the same as in 1.2. After applying the sample for 30 minutes, the sample was wiped off. The a value of each test site was measured using a skin colorimeter probe. Compared with the blank group (comparative application example 19), the a value reduction rate was calculated to evaluate the redness reduction of each component and the composition.

[0110] The calculation method is as follows:

[0111] a-value reduction rate (%) = (a-blank group - a-subject group) / a-blank group × 100%.

[0112] 2.3 Experimental Results

[0113] The results are shown in Table 3 and Figure 1 As shown. Among them, Figure 1 (a) shows the change in erythema on the skin after 2 hours using the sample from Application Example 1; (b) shows the change in erythema on the skin after 2 hours using the sample from Comparative Application Example 19.

[0114] Table 3

[0115]

[0116] As can be seen from the data in Table 3, various soothing ingredients and combinations have a certain redness-reducing effect. However, the combination method of the present invention not only has a significant redness-reducing effect within 30 minutes, but also the erythema continues to fade after 2 hours. In contrast, the immediate soothing effect of application examples 1-18 is weaker than that of the application examples, and the effect of fading the erythema within 2 hours is not obvious.

[0117] from Figure 1 It can be seen that the erythema on the skin was significantly reduced after 2 hours using the sample of Application Example 1, while the erythema on the skin was still obvious after 2 hours using the sample of Comparative Application Example 19.

[0118] In addition, the erythema was no longer visible to the naked eye after 4 hours when using the samples of Application Examples 1-3; while the erythema was still quite obvious after 4 hours when using the samples of Comparative Application Examples 1-18.

[0119] Experiment Example 3: Itch Relief and Swelling Reduction Test

[0120] 3.1 Experimental Principle

[0121] The release of histamine, an itch-sensing mediator among inflammatory factors, is one of the important causes of skin itching. Based on this principle, a histamine stimulation model was established, and the antipruritic and anti-swelling efficacy of the examples and comparative samples was evaluated through topical application.

[0122] 3.2 Experimental Methods

[0123] Thirty-three subjects, aged 25–50 years, were randomly selected. Two 1cm × 1cm test sites were chosen on each of the left and right upper arms for histamine prick tests. After 30 minutes of pricking, the test sample was applied. One test site was randomly selected to receive the control application example 19, while the remaining test sites were randomly selected to receive application examples 1–3 and control application examples 1–18. After 30 minutes of application, the samples were wiped off, and the itching and wheals at the test sites were observed. The subjects were scored based on their perception.

[0124] Scoring criteria: -1 point - Increased discomfort; 0 points - No relief; 1 point - Slight relief; 2 points - Some relief; 3 points - Significant relief.

[0125] 3.3 Experimental Results

[0126] The results are shown in Table 4, and the scores are based on the average score.

[0127] Table 4

[0128]

[0129]

[0130] As can be seen from the data in Table 4, there were significant differences in the antipruritic and anti-swelling effects of the samples after 30 minutes of use in the application examples and control examples. Although various soothing ingredients and combinations all showed some antipruritic and anti-swelling effects compared to the blank, the combination method of this invention not only provided noticeable relief from itching and swelling within 30 minutes, but also made the wheals virtually invisible after 2 hours. In contrast, control examples 1-19 still showed traces of wheals after 2 hours, with a significantly weaker soothing effect than the application examples. Some control examples even showed no immediate soothing effect. Generally, the control examples only provided noticeable relief after 15-30 minutes, and even after 2 hours, the wheal fading effect was still not significant in some control examples.

[0131] Experiment Example 4: Consumer Sensory Testing

[0132] 4.1 Experimental Principle

[0133] Through real-world trials by consumers with sensitive skin, the product's actual efficacy in relieving several highly reactive aspects of the skin, such as stinging, burning, redness, itching, and tightness, was evaluated.

[0134] 4.2 Experimental Methods

[0135] Thirty-three subjects with sensitive skin, aged 35-50, were randomly selected for half-face testing. They used the product on one side of their face once in the morning and once in the evening for four consecutive weeks. Follow-up visits were conducted at weeks 2 and 4 to evaluate the product's soothing and repairing effects.

[0136] Scoring criteria: -1 point - Increased discomfort; 0 points - No relief; 1 point - Slight relief; 2 points - Some relief; 3 points - Significant relief.

[0137] 4.3 Experimental Results

[0138] The results are shown in Table 5, and the scores are averages.

[0139] Table 5

[0140]

[0141] As can be seen from the data in Table 5, compared with Comparative Application Example 19, Application Example 1 has a significant soothing effect, and can significantly relieve various discomforts such as stinging, burning, redness, itching, and tightness of the skin during the sensitive process. The base material of Comparative Application Example 19 is itself a relatively moisturizing cream system, which can relieve dryness and tightness of the skin to a certain extent; however, Application Example 1 contains the composition of the present invention, which also has the effect of promoting skin repair, and its effect of relieving dryness and tightness is more significant.

[0142] The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the embodiments described. Those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention, and these equivalent modifications or substitutions are all included within the scope defined by the claims of this application.

Claims

1. A composition, characterized in that, The composition comprises the following components in parts by weight: 1-30 parts of hydroxyphenylpropionamide benzoic acid and chamomile oil, 10-70 parts of bisabolol and asiaticoside, 1-30 parts of kava leaf / root / stem extract and menthol lactate, and 10-70 parts of edelweiss callus extract.

2. The composition according to claim 1, characterized in that, The composition comprises the following components in parts by weight: 1-20 parts of hydroxyphenylpropionamide benzoic acid and chamomile oil, 20-60 parts of bisabolol and asiaticoside, 1-20 parts of kava leaf / root / stem extract and menthol lactate, and 20-70 parts of edelweiss callus extract.

3. The composition according to claim 2, characterized in that, The composition comprises the following components in parts by weight: 1-10 parts of hydroxyphenylpropionamide benzoic acid and chamomile oil, 30-50 parts of bisabolol and asiaticoside, 5-15 parts of kava leaf / root / stem extract and menthol lactate, and 50-70 parts of edelweiss callus extract.

4. A method for preparing the composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: The components are mixed to obtain the composition.

5. A cosmetic product, characterized in that, Includes the composition according to any one of claims 1 to 3.

6. The cosmetic product according to claim 5, characterized in that, The cosmetics include facial cleansers, toners, lotions, foundations, face masks, or body lotions.

7. The cosmetic product according to claim 5, characterized in that, The composition is added to the cosmetic at an amount of 0.05 to 5 wt%.

8. The cosmetic product according to claim 7, characterized in that, The composition is added to the cosmetic at an amount of 0.5 to 2 wt%.

9. A face cream, characterized in that, Includes the composition according to any one of claims 1 to 3.

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