A method for synthesizing hexa-substituted oxy-cyclotriphosphazene compounds
By reacting hexachlorocyclotriphosphazene with specific compounds under potassium trimethylsilanolate catalysis and combining with optimized post-processing, the problems of long synthesis time, high risk and high cost of hexasubstituted oxycyclotriphosphazene in the prior art have been solved, realizing an efficient, safe and environmentally friendly synthesis method.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- XIAN MODERN CHEM RES INST
- Filing Date
- 2023-06-13
- Publication Date
- 2026-05-15
AI Technical Summary
Existing methods for synthesizing hexasubstituted oxycyclotriphosphazenes suffer from problems such as long reaction times, high risks, high costs, and complex processes, making them particularly unsuitable for the synthesis of alkoxycyclotriphosphazene derivatives.
A highly efficient synthesis was achieved by reacting hexachlorocyclotriphosphazene with compounds such as phenol/4-nitrophenol/trifluoroethanol/4-ethylphenol/4-methoxyphenol/4-methylthioether-based phenol under potassium trimethylsilanolate catalysis, combined with 2-methyltetrahydrofuran solvent and optimized post-treatment process.
This method enables the efficient, safe, and environmentally friendly synthesis of hexasubstituted oxycyclotriphosphazenes, is compatible with different functional groups, reduces wastewater and waste liquid generation, and lowers synthesis costs.
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of chemical and polymer material additives, and relates to a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Background Technology
[0002] Phosphazenes possess excellent flame retardant properties and superior heat resistance due to their unique chemical structure. As a novel phosphorus flame retardant, hexasubstituted oxycyclic triphosphazenes have broad application value, and different application requirements can be met depending on the nature of the substituents. For example, hexaphenoxycyclic triphosphazenes and their derivatives exhibit outstanding characteristics such as excellent heat resistance, hydrolysis resistance, good compatibility with polymer materials, and significant flame retardant efficiency, making them one of the current hot topics in halogen-free flame retardant research. Alkoxycyclic triphosphazene derivatives, such as hexa(2,2,2-trifluoroethoxy)cyclic triphosphazenes, can be used as flame retardants for lithium-ion battery electrolytes.
[0003] Currently, the synthesis methods of hexasubstituted oxycyclotriphosphazenes can be divided into three main categories. The first method uses an acid-binding agent as a catalyst. In a solvent system, phenol reacts directly with hexachlorocyclotriphosphazenes, and the product is then obtained after further processing. Common acid-binding agents include potassium carbonate, triethylamine, and potassium phosphate. The synthesis of hexasubstituted oxycyclotriphosphazenes is promoted by acid-binding agents. Examples include patents CN 121406C, US00552319A, and US5075453. However, due to the alkalinity of the acid-binding agent, this method has a long reaction time and is unsuitable for the synthesis of alkoxycyclotriphosphazene derivatives. The second method involves first reacting sodium metal or sodium hydride with a phenol or alcohol in an ether solvent such as tetrahydrofuran to obtain sodium phenolate or sodium alkoxide, which is then reacted with hexachlorocyclotriphosphazene to obtain the target product. The synthesis of hexasubstituted oxycyclotriphosphazenes is promoted by sodium metal or sodium hydride.
[0004] Examples include CN10358815A, CN106356558, US6518836, and US6627122. The use of highly reactive metallic sodium or sodium hydride significantly increases the overall risk of the method and makes it incompatible with phenols possessing highly reactive functional groups, such as nitro groups. Furthermore, the stepwise preparation of sodium phenolate, sodium alkoxide, and hexachlorocyclotriphosphazene derivatives increases reaction time and processing steps, ultimately raising the synthesis cost of the hexachlorocyclotriphosphazene derivatives. A third method involves reacting phenols or alcohols with sodium hydroxide or potassium hydroxide to generate sodium phenolate or sodium alkoxide, which is then reacted with hexachlorocyclotriphosphazene to obtain the target product. This metal hydroxide-promoted synthesis of hexachlorocyclotriphosphazenes is described below. Examples include CN113024605A, CN103539820A, and CN101648978A. The water generated during the preparation of sodium phenolate or sodium alkoxide in this method requires an additional dehydration process or the use of solvents such as toluene or chlorobenzene that can azeotropically react with water for water separation, which greatly complicates the entire process. Summary of the Invention
[0005] To address the shortcomings of existing technologies, the present invention aims to provide a method for synthesizing hexasubstituted oxycyclotriphosphazene compounds that is efficient, environmentally friendly, and has broad substrate applicability.
[0006] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:
[0007] A method for synthesizing a hexasubstituted oxycyclic triphosphazene compound, wherein the hexasubstituted oxycyclic triphosphazene compound has the following general formula (I):
[0008]
[0009] Wherein, R = Ph, 4-NO2-Ph, TFE, 4-Et-Ph, 4-MeO-Ph, 4-MeS-Ph;
[0010] The raw materials for this synthesis method include: hexachlorocyclotriphosphazene, one or two of the following: phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol, and potassium trimethylsilanolate catalyst.
[0011] The present invention also includes the following technical features:
[0012] Specifically, the synthesis method includes: under nitrogen atmosphere, dissolving the crystallized hexachlorocyclotriphosphazene in a solvent, adding it to a solution of one or two of phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol, and then adding potassium trimethylsilanolate, and reacting for 6-24 hours; after the reaction is completed, the corresponding hexasubstituted oxycyclotriphosphazene derivative is obtained through post-treatment.
[0013] Specifically, in the raw materials, the molar ratio of one of the following, phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol, or potassium dimethylsilyl tartar is 1:6 to 7.69:6 to 7.99.
[0014] Specifically, the reaction temperature is 65-100℃.
[0015] Specifically, the post-processing includes: restoring to room temperature, adding deionized water, and separating the liquid; washing the organic phase sequentially with water and then with saturated brine; concentrating the organic phase to a small volume, adding a large amount of deionized water, and washing out the solid; filtering and drying to obtain the corresponding hexasubstituted oxycyclotriphosphazene derivative.
[0016] Specifically, the solvent is 2-methyltetrahydrofuran, CPME, or tetrahydrofuran.
[0017] Specifically, the solvent in the solution of one or two of phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol is 2-methyltetrahydrofuran, CPME or tetrahydrofuran, and is the same as the solvent of hexachlorocyclotriphosphazene.
[0018] Specifically, in this synthesis method, when the raw materials are hexachlorocyclotriphosphazene, phenol, and potassium trimethylsilanolate, R in general formula (I) is Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-nitrophenol, and potassium trimethylsilanolate, R in general formula (I) is 4-NO2-Ph; when the raw materials are hexachlorocyclotriphosphazene, trifluoroethanol, and potassium trimethylsilanolate, R in general formula (I) is TFE; when the raw materials are hexachlorocyclotriphosphazene, 4-ethylphenol, and potassium trimethylsilanolate, R in general formula (I) is 4-Et-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-methoxyphenol, and potassium trimethylsilanolate, R in general formula (I) is 4-MeO-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-methylthiophenol, and potassium trimethylsilanolate, R in general formula (I) is 4-MeS-Ph.
[0019] Specifically, when the raw materials for this synthesis method are hexachlorocyclotriphosphazene, 4-ethylphenol, 4-methoxyphenol and potassium trimethylsilanolate, R in general formula (I) is 4-Et-Ph and 4-MeO-Ph.
[0020] Compared with the prior art, the present invention has the following technical effects:
[0021] This invention utilizes a highly safe and low-toxicity solvent, potassium trimethylsilanolate, to synthesize hexasubstituted oxycyclotriphosphazenes of phenols and alkyl alcohols. Furthermore, the optimized post-treatment method efficiently removes residual phenols and salts from the reaction system, significantly reducing wastewater and waste liquid generated during post-treatment.
[0022] The method of this invention has good versatility and is compatible with phenols and alcohols containing different types of functional groups.
[0023] This invention uses 2-methyltetrahydrofuran as the reaction solvent, and the reaction system can be directly washed with water to fully remove phenols (alcohols) and salts.
[0024] The potassium trimethylsilanolate of this invention is highly active, safe, non-toxic, and leaves no residue. Detailed Implementation
[0025] This invention provides a method for synthesizing hexasubstituted oxycyclic triphosphazene compounds, the synthetic route of which is as follows:
[0026]
[0027] Specific formulation: The hexasubstituted oxycyclic triphosphazene compound has the following general formula (I):
[0028]
[0029] Wherein, R = Ph, 4-NO2-Ph, TFE, 4-Et-Ph, 4-MeO-Ph, 4-MeS-Ph;
[0030] The raw materials for this synthesis method include hexachlorocyclotriphosphazene, as well as phenol, 4-nitrophenol or trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol / one or two of them, and potassium trimethylsilanolate as a catalyst.
[0031] The synthetic method includes: under nitrogen atmosphere, dissolving crystallized hexachlorocyclotriphosphazene in a solvent, adding it to a solution of one or two of phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol, and then adding potassium trimethylsilanolate, reacting at 65-100℃ for 6-24 h; after the reaction, obtaining the corresponding hexasubstituted oxycyclotriphosphazene derivative through post-treatment. Post-treatment includes: restoring to room temperature, adding deionized water, separating the liquid phase; washing the organic phase sequentially with water and saturated brine; concentrating the organic phase to a small volume, adding a large amount of deionized water, washing off the solid; filtering, and drying to obtain the corresponding hexasubstituted oxycyclotriphosphazene derivative.
[0032] The solvent is 2-methyltetrahydrofuran, CPME, or tetrahydrofuran.
[0033] The solvent in the solution of one or two of phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol is 2-methyltetrahydrofuran, CPME or tetrahydrofuran, and is the same as the solvent of hexachlorocyclotriphosphazene.
[0034] When the raw materials for this synthesis method are hexachlorocyclotriphosphazene, phenol, and potassium trimethylsilanolate, R in general formula (I) = Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-nitrophenol, and potassium trimethylsilanolate, R in general formula (I) = 4-NO2-Ph; when the raw materials are hexachlorocyclotriphosphazene, trifluoroethanol, and potassium trimethylsilanolate, R in general formula (I) = TFE; when the raw materials are hexachlorocyclotriphosphazene, 4-ethylphenol, and potassium trimethylsilanolate, R in general formula (I) = 4- Et-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-methoxyphenol and potassium trimethylsilanolate, R in general formula (I) is 4-MeO-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-methylthiophenol and potassium trimethylsilanolate, R in general formula (I) is 4-MeS-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-ethylphenol, 4-methoxyphenol and potassium trimethylsilanolate, R in general formula (I) is 4-Et-Ph and 4-MeO-Ph.
[0035] Potassium trimethylsilanolate was selected to accelerate the substitution reaction of hexachlorocyclotriphosphazene with phenol or alcohol (phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol / one or two of these), and it has broad functional group compatibility.
[0036] In the raw materials, the molar ratio of hexachlorocyclotriphosphazene, phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol / one of these or potassium dimethylsilyl alcohol is 1:6 to 7.69:6 to 7.99.
[0037] More specifically, the molar ratio of hexachlorocyclotriphosphazene, (phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol / one or two of these) and potassium trimethylsilanolate is 1:7.6:7.92.
[0038] After the reaction is complete, the reaction system is first washed with water to remove a large amount of salt and phenol (alcohol), then washed with saturated brine to remove residual water and salt, then the reaction system is concentrated to a minimum, and then deionized water is added to precipitate the product.
[0039] The post-treatment method involves first removing residues such as salt and phenol, and then precipitating the product, which can greatly reduce the wastewater and waste liquid generated during the post-treatment process.
[0040] The resulting product contains virtually no phenol or salt residues and requires no additional purification.
[0041] The following are specific embodiments of the present invention. It should be noted that the present invention is not limited to the following specific embodiments. All equivalent modifications made based on the technical solutions of this application fall within the protection scope of the present invention.
[0042] Example 1:
[0043] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, phenol (71.44g), 2-MeTHF (325mL), and then a 2-MeTHF solution (34.5g) of hexachlorocyclotriphosphazene (300mL) was added. Finally, potassium trimethylsilanolate (101g) was added. The reaction was refluxed at 80°C for 12 hours to terminate the reaction. After returning to room temperature, the reaction system was washed with deionized water (0.5L), then with saturated brine (0.5L). The reaction system was then concentrated to a minimum volume, and deionized water was added again. A colorless solid precipitated, which was filtered and dried to obtain 63g of colorless solid hexaphenoxycyclotriphosphazene (91% yield). 1 H NMR (500MHz, CDCl3): δ7.09 (t, J = 7.5 Hz, 2H), 7.03 (t, J = 7.0 Hz, 1H), 6.84 (d, J = 8.0 Hz, 2H). 31 P NMR (202MHz, CDCl3): δ 8.74.
[0044] Example 2:
[0045] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, phenol (71.44g), CPME (325mL), and then a CPME solution of hexachlorocyclotriphosphazene (34.5g) (300mL) were added. Finally, potassium trimethylsilanolate (101g) was added. The reaction was refluxed at 100°C for 24h to terminate the reaction. After returning to room temperature, the reaction system was washed first with deionized water (0.5L), then with saturated brine (0.5L), and then concentrated to a minimum volume. Deionized water was added again, and a colorless solid precipitated. The solid was filtered and dried to obtain 50g of colorless solid hexaphenoxycyclotriphosphazene (72% yield).
[0046] Example 3:
[0047] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, phenol (71.44 g), THF (325 mL), and then a THF solution of hexachlorocyclotriphosphazene (34.5 g) (300 mL) were added sequentially. Finally, potassium trimethylsilanolate (101 g) was added. The reaction was refluxed at 65°C for 24 h, and then the reaction was stopped. After returning to room temperature, deionized water (500 mL) was added to precipitate a colorless solid, which was then filtered. The filter cake was washed successively with deionized water (500 mL) and ethanol (500 mL), and dried to obtain 60 g of colorless solid hexaphenoxycyclotriphosphazene (87% yield).
[0048] Example 4:
[0049] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, 105g of 4-nitrophenol and 325mL of 2-MeTHF were added sequentially. Then, a 300mL solution of 34.5g of hexachlorocyclotriphosphazene in 2-MeTHF was added, followed by 101g of potassium trimethylsilanolate. The reaction was refluxed at 80°C for 12 hours, and then the reaction was stopped. After returning to room temperature, 1L of deionized water was added, and a colorless solid precipitated. The solid was filtered. 0.5L of deionized water was added to the filter cake, and the mixture was stirred vigorously. The mixture was then filtered, washed with ice-cold ethanol, and the filter cake was dried to obtain 78g of colorless solid hexa(4-nitrophenoxy)cyclotriphosphazene (81% yield). 1 H NMR (500MHz, DMSO-d6): δ8.16 (d, J = 9.0 Hz, 2H), 7.31 (d, J = 9.0 Hz, 2H). 31 P NMR (202MHz, DMSO-d6): δ 7.29.
[0050] Example 5:
[0051] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, trifluoroethanol (76g), 2-MeTHF (325mL), and then a 2-MeTHF solution (300mL) of hexachlorocyclotriphosphazene (34.5g) were added to the system. Finally, potassium trimethylsilanolate (101g) was added. The reaction was refluxed at 80°C for 6 hours to terminate the reaction. After returning to room temperature, the reaction system was washed twice with deionized water (0.5L), then washed with saturated brine (0.5L), and then concentrated to obtain 58g of colorless solid hexa(2,2,2-trifluoroethoxy)cyclotriphosphazene (80% yield). 1 H NMR (500MHz, CDCl3): δ4.29 (s, 2H). 19 FNMR (470MHz, CDCl3): δ-75.45. 31 PNMR (202MHz, CDCl3): δ 16.86.
[0052] Example 6:
[0053] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, 92.7g of 4-ethylphenol and 325mL of 2-MeTHF were added sequentially. Then, a 300mL solution of 34.5g of hexachlorocyclotriphosphazene in 2-MeTHF was added, followed by 101g of potassium trimethylsilanolate. The reaction was refluxed at 80°C for 12 hours, and then the reaction was stopped. After returning to room temperature, 1L of deionized water was added, and a colorless solid precipitated. The solid was filtered. 0.5L of deionized water was added to the filter cake, and the mixture was stirred vigorously. The mixture was then filtered, washed with ice-cold ethanol, and the filter cake was dried to obtain 80g of colorless solid hexa(4-ethylphenoxy)cyclotriphosphazene (92% yield). 1 HNMR (500MHz, CDCl3): δ6.97(d,J=8.5Hz,2H), 6.82(d,J=9.0Hz,2H), 2.59(q,J=7.5Hz,2H), 1.20(d,J=7.5Hz,3H). 31 P NMR (202MHz, CDCl3): δ 9.12.
[0054] Example 7:
[0055] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, 94g of 4-methoxyphenol and 325mL of 2-MeTHF were added sequentially. Then, a 300mL solution of 34.5g of hexachlorocyclotriphosphazene in 2-MeTHF was added, followed by 101g of potassium trimethylsilanolate. The reaction was refluxed at 80°C for 12 hours, and then the reaction was stopped. After returning to room temperature, 1L of deionized water was added, and a colorless solid precipitated. The solid was filtered. 0.5L of deionized water was added to the filter cake, and the mixture was stirred vigorously. The mixture was then filtered, washed with ice-cold ethanol, and the filter cake was dried to obtain 75g of colorless solid hexa(4-methoxyphenoxy)cyclotriphosphazene (86% yield). 1 H NMR (500MHz, CDCl3): δ6.76 (d, J = 9.0 Hz, 2H), 6.60 (d, J = 9.0 Hz, 2H), 3.69 (s, 3H). 31 P NMR (202MHz, CDCl3): δ 9.97.
[0056] Example 8:
[0057] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, 106.4g of 4-methylthiophenoxyphenol and 325mL of 2-MeTHF were added sequentially. Then, a 300mL solution of 34.5g of hexachlorocyclotriphosphazene in 2-MeTHF was added, followed by 101g of potassium trimethylsilanolate. The reaction was refluxed at 80°C for 12 hours, and then the reaction was stopped. After returning to room temperature, 1L of deionized water was added, and a colorless solid precipitated. The solid was filtered. 0.5L of deionized water was added to the filter cake, and the mixture was stirred vigorously. The mixture was then filtered, washed with ice-cold ethanol, and the filter cake was dried to obtain 70g of colorless solid hexa(4-methylthiophenoxy)cyclotriphosphazene (72% yield). 1 H NMR (500MHz, CDCl3): δ7.99 (d, J = 9.0Hz, 2H), 6.72 (d, J = 8.5Hz, 2H), 2.41 (s, 3H). 31 P NMR (202MHz, CDCl3): δ 9.49.
[0058] Example 9:
[0059] This embodiment provides a method for synthesizing a hexasubstituted oxycyclotriphosphazene compound. Under nitrogen atmosphere, in a 1L three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer, 4-methoxyphenoxy (47.1g), 4-ethylphenoxy (46.4g), and 2-MeTHF (325mL) were added sequentially. Then, a 2-MeTHF solution (300mL) of hexachlorocyclotriphosphazene (34.5g) was added to the system, and finally, potassium trimethylsilanolate (101g) was added. The reaction was refluxed at 80℃ for 12h, and the reaction was terminated. After returning to room temperature, 1L of deionized water was added first, and a colorless solid precipitated from the system. The mixture was filtered. The filter cake was added to 0.5L of deionized water and stirred vigorously. The mixture was filtered, washed with ice-cold ethanol, and the filter cake was dried to obtain 65g of colorless solid tris(4-methoxyphenoxy)tris(4-ethylphenoxy)cyclotriphosphazene (74% yield). 1 H NMR (500MHz, CDCl3): δ6.99 (brs, 2H), 6.82 (brs, 4H), 6.66 (brs, 2H), 3.75 (s, 3H), 2.60 (q, J = 7.5 Hz, 2H), 1.21 (t, J = 8.0 Hz, 3H). 31 P NMR (202 MHz, CDCl3): δ 9.54.
Claims
1. A method for synthesizing a hexasubstituted oxycyclic triphosphazene compound, characterized in that, The hexasubstituted oxycyclic triphosphazene compound has the following general formula (I): Wherein, R = Ph, 4-NO2-Ph, TFE, 4-Et-Ph, 4-MeO-Ph, 4-MeS-Ph; The raw materials for this synthesis method include: hexachlorocyclotriphosphazene, one or two of the following: phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol, and potassium trimethylsilanolate catalyst.
2. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 1, characterized in that, The synthesis method includes: under nitrogen atmosphere, dissolving crystallized hexachlorocyclotriphosphazene in a solvent, adding it to a solution of one or two of phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthioether-based phenol, then adding potassium trimethylsilanolate, and reacting for 6-24 hours; after the reaction is completed, the corresponding hexasubstituted oxycyclotriphosphazene derivative is obtained through post-treatment.
3. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 2, characterized in that, In the raw materials, the molar ratio of one of the following, phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol, or potassium dimethylsilyl tartar is 1:6 to 7.69:6 to 7.
99.
4. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 2, characterized in that, The reaction temperature is 65-100℃.
5. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 2, characterized in that, The post-processing includes: restoring to room temperature, adding deionized water, and separating the liquid; washing the organic phase sequentially with water and then with saturated brine; concentrating the organic phase to a small volume, adding a large amount of deionized water, and washing out the solid; filtering and drying to obtain the corresponding hexasubstituted oxycyclotriphosphazene derivative.
6. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 2, characterized in that, The solvent is 2-methyltetrahydrofuran, CPME, or tetrahydrofuran.
7. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 4, characterized in that, The solvent in the solution of one or two of the following: phenol / 4-nitrophenol / trifluoroethanol / 4-ethylphenol / 4-methoxyphenol / 4-methylthiophenol is 2-methyltetrahydrofuran, CPME, or tetrahydrofuran, and is the same as the solvent of hexachlorocyclotriphosphazene.
8. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 1, characterized in that, In this synthetic method, when the raw materials are hexachlorocyclotriphosphazene, phenol, and potassium trimethylsilanolate, R in general formula (I) is Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-nitrophenol, and potassium trimethylsilanolate, R in general formula (I) is 4-NO2-Ph; when the raw materials are hexachlorocyclotriphosphazene, trifluoroethanol, and potassium trimethylsilanolate, R in general formula (I) is TFE; when the raw materials are hexachlorocyclotriphosphazene, 4-ethylphenol, and potassium trimethylsilanolate, R in general formula (I) is 4-Et-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-methoxyphenol, and potassium trimethylsilanolate, R in general formula (I) is 4-MeO-Ph; when the raw materials are hexachlorocyclotriphosphazene, 4-methylthiophenol, and potassium trimethylsilanolate, R in general formula (I) is 4-MeS-Ph.
9. The method for synthesizing the hexasubstituted oxycyclic triphosphazene compound as described in claim 1, characterized in that, When the raw materials for this synthesis method are hexachlorocyclotriphosphazene, 4-ethylphenol, 4-methoxyphenol and potassium trimethylsilanolate, R in general formula (I) is 4-Et-Ph and 4-MeO-Ph.