A Chinese medicine composition for preventing and treating colorectal adenoma recurrence and canceration, and its preparation method and application

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma, and a preparation method and application thereof. The raw materials of the traditional Chinese medicine composition include bran-fried atractylodes, coix seeds, oldenlandia diffusa, pseudostellaria, vinegar-curcuma, bergamot and euphorbia pulex, and the composition has the effects of clearing turbidity and detoxifying, eliminating symptoms and dispersing nodules, can effectively prevent the recurrence after colorectal adenoma resection and delay the progression of intestinal adenoma, further reduce the incidence of intestinal cancer, have clear clinical efficacy and are low in price.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating colorectal adenoma recurrence and canceration, and a preparation method and application thereof. Background Art

[0002] Intestinal polyps refer to the hyperplasia of the intestinal mucosal epithelium, forming polyp-like growths that protrude into the intestinal cavity. Patients with intestinal polyps may have no clinical symptoms, but some may experience abdominal distension, abdominal pain, increased mucus in the stool, and blood in the stool in severe cases. Intestinal polyps can be divided into neoplastic and non-neoplastic based on pathological manifestations. Neoplastic polyps are adenomatous polyps, and non-neoplastic polyps include hyperplastic, inflammatory polyps, and hamartoma polyps. Colorectal adenoma is a benign glandular epithelial tumor originating from the intestinal epithelium. The interior may be composed of tubular, villous, or serrated structures. It is the most common precancerous lesion of colorectal cancer, accounting for 85%-90% of all precancerous lesions of colorectal cancer. At present, endoscopic treatment is mostly used in clinical treatment of colorectal adenomas. However, factors such as the patient's intestinal preparation, the level of endoscopic examination physicians, and endoscopic treatment methods have an impact on the endoscopic detection rate and treatment effect. Therefore, how to reduce and prevent postoperative recurrence and canceration of colorectal adenomas is an important topic in the current prevention and treatment of colorectal cancer. Summary of the invention

[0003] In view of the above technical problems, the present invention provides a Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma, and its preparation method and application. The Chinese medicine composition has the effects of clearing turbidity and detoxifying, eliminating symptoms and dispersing nodules, and can effectively prevent and treat the recurrence and canceration of colorectal adenoma.

[0004] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions:

[0005] On the one hand, the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. The raw materials thereof include, by weight: 12 to 18 parts of stir-fried atractylodes lancea, 27 to 33 parts of coix seeds, 12 to 18 parts of oldenlandia diffusa, 12 to 18 parts of pseudostellaria, 6 to 10 parts of vinegar-cured zedoaria, 6 to 10 parts of citron and 12 to 18 parts of euphorbia pulex.

[0006] The Chinese medicine composition of the present invention adopts the treatment method of "clearing turbidity and detoxifying". It has been confirmed through clinical practice that the prescription can effectively prevent the recurrence after colorectal adenoma resection and delay the progression of intestinal adenoma, and delay the process of carcinogenesis and reduce the incidence of carcinogenesis. It has clear efficacy and low price.

[0007] In addition, during clinical use, it was found that for patients with chronic enteritis, the Chinese medicine composition can also significantly relieve their clinical symptoms such as abdominal distension, abdominal pain, sticky and uncomfortable stools or constipation.

[0008] Among the various Chinese medicines in the above formula:

[0009] Fried Atractylodes with Glutinous Rice Bran: pungent, bitter, warm; dries dampness and affects the spleen, dispels wind and cold, improves eyesight;

[0010] Coix seeds: sweet, light, cool; diuretic, invigorating the spleen and stopping diarrhea, removing numbness, draining pus, detoxifying and dispersing stagnation;

[0011] Hedyotis diffusa: slightly bitter, sweet, and cold; clears away heat and detoxifies, promotes diuresis and reduces swelling, promotes blood circulation and relieves pain;

[0012] Pseudostellariae Radix: sweet, slightly bitter, neutral; replenishes qi and strengthens the spleen, produces body fluid and moistens the lungs;

[0013] Vinegar Curcuma: pungent, bitter, warm; promotes qi and resolves blood, eliminates stagnation and relieves pain;

[0014] Buddha’s hand: pungent, bitter, warm; soothes the liver and relieves depression, regulates qi and harmonizes the middle, dries dampness and resolves phlegm;

[0015] Herba Dijinjiu: pungent, neutral; clears away heat and detoxifies, cools blood and stops bleeding, promotes dampness and reduces jaundice.

[0016] In the formula, Herba Dijincao clears heat and dampness, activates blood circulation and detoxifies, while Herba Hedyotis diffusae clears heat, activates dampness and detoxifies. The two herbs are used together to cleanse the turbid toxins that have been accumulated in the intestines for a long time, so that the turbidity can be detoxified, which is a treatment that treats the root cause. They are the main herbs. Radix Pseudostellariae and Rhizoma Atractylodis Macrocephalae can strengthen the spleen and dry dampness, detoxify turbidity and thicken the intestines, which can prevent the turbid toxins from being transformed and regenerated, and restrain the bitter and cold herbs from directly breaking the wound. They are the assistant herbs. Semen Coix Seed clears heat and dampness, disperses knots and eliminates carbuncle, while Rhizoma Curcumae can activate blood circulation and eliminate symptoms, and prevent recurrence by activating blood circulation and dispersing knots. They are the adjuvant herbs. Citron can regulate qi and resolve phlegm, relieve pain and stop pain, which is the guiding herbs.

[0017] Clinical observations have shown that taking the Chinese medicine composition provided by the present invention for 3 to 6 months can effectively reduce the probability of recurrence of colorectal adenoma, thereby reducing the possibility of colorectal adenoma canceration.

[0018] In clinical application, the decoction pieces of the above-mentioned Chinese medicines can be mixed according to the weight ratio and then decocted in water for warm consumption. Alternatively, the decoction-free granules of each Chinese medicine can be weighed according to the weight ratio of the raw medicines and taken with boiled water after mixing.

[0019] Preferably, the raw materials of the traditional Chinese medicine composition include 14-16 parts of stir-fried atractylodes lancea, 28-31 parts of coix seeds, 14-16 parts of oldenlandia diffusa, 14-16 parts of pseudostellaria, 6-10 parts of vinegar-cured zedoaria, 8-10 parts of citron and 14-16 parts of euphorbia pulex.

[0020] Preferably, the raw materials of the traditional Chinese medicine composition include 15 parts of stir-fried Atractylodes lancea with bran, 30 parts of Coix seeds, 15 parts of Oldenlandia diffusa, 15 parts of Pseudostellaria heterophylla, 9 parts of Curcuma zedoariae with vinegar, 9 parts of Citron and 15 parts of Herba Euphorbiae Iris.

[0021] Preferably, during clinical use, the prescription can be added or subtracted by diagnosing the patient's symptoms through the four diagnostic methods. Specifically:

[0022] Patients with damp-heat stagnation type are often accompanied by abdominal distension or pain, dry mouth and bitter taste, thirst and drinking, or diarrhea, yellow-brown and foul-smelling stool, burning sensation in the anus, tenesmus, or constipation, short and red urine, red tongue, yellow and greasy fur, and a stringy or slippery pulse. The treatment method is mainly to clear away heat and eliminate dampness. When the Chinese medicine composition is used to prevent and treat colorectal adenoma recurrence and canceration in patients with damp-heat stagnation type, the Chinese medicine composition also includes 5-7 parts of Coptis chinensis, 12-18 parts of Scutellaria barbata, 16-24 parts of Patrinia scabra, 12-18 parts of Pyrus truncatula, 12-18 parts of Herba Artemisiae Argyi, and 12-18 parts of Herba Codonopsis pilosulae by mass, so as to clear away heat, eliminate dampness and detoxify. A further preferred mass ratio is: 5.5-6.5 parts of coptis root, 13.5-16.5 parts of scutellaria barbata, 18-22 parts of patrinia scabra, 13.5-16.5 parts of radix scutellariae, 13.5-16.5 parts of scutellaria baicalensis, 13.5-16.5 parts of scutellaria baicalensis; a further optimized mass ratio is: 6 parts of coptis root, 15 parts of scutellaria barbata, 20 parts of patrinia scabra, 15 parts of radix scutellariae, 15 parts of scutellaria baicalensis, 15 parts of scutellaria baicalensis;

[0023] Patients with cold-dampness obstruction type are often accompanied by abdominal distension, poor appetite, dull pain in the abdomen, severe pain when encountering cold, pain relieved by warmth, bland mouth without thirst, cold body and cold limbs, clear and long urine, clear and thin stool, even watery or difficult stool, bowel sounds, tenesmus, pale tongue, white or greasy tongue coating, and deep and tight pulse. Treatment is mainly based on warming and removing cold-dampness. When the Chinese medicine composition is used to prevent and treat colorectal adenoma recurrence and canceration in patients with cold-dampness obstruction type, the Chinese medicine composition also includes 5-7 parts of Amomum villosum, 8-12 parts of Cardamom, 8-12 parts of Aucklandia lappa, 7-11 parts of Alpinia galanga, 9.5-14.5 parts of Magnolia officinalis, and 8-12 parts of Tangerine peel in terms of mass proportions to warm the middle and dispel cold and resolve phlegm. A further preferred mass ratio is: 5.5-6.5 parts of Amomum villosum, 9-11 parts of Cardamom, 9-11 parts of Aucklandia lappa, 8-10 parts of Alpinia officinalis, 11-13 parts of Magnolia officinalis, and 9-11 parts of Tangerine peel; a further optimized mass ratio is: 6 parts of Amomum villosum, 10 parts of Cardamom, 10 parts of Aucklandia lappa, 9 parts of Alpinia officinalis, 12 parts of Magnolia officinalis, and 10 parts of Tangerine peel;

[0024] Patients with blood stasis obstruction syndrome are often accompanied by abdominal pain, distension, or stabbing pain, which comes and goes, frequent belching, aggravated when in a bad mood, bowel sounds and flatulence, dry and hard stools, or loose stools, tenesmus, dark tongue or ecchymosis, thin white fur, stringy or astringent pulse, and treatment is mainly based on invigorating qi, activating blood circulation and dispersing nodules. When the Chinese medicine composition is used to prevent and treat colorectal adenoma recurrence and canceration in patients with blood stasis obstruction syndrome, the Chinese medicine composition also includes 12 to 18 parts of astragalus, 12 to 18 parts of Gleditsia sinensis, 9.5 to 14.5 parts of red peony root, 12 to 18 parts of rhodiola rosea, 8 to 12 parts of angelica and 2.5 to 3.5 parts of Panax notoginseng in terms of mass proportions, so as to invigorate qi, activate blood circulation and dredge collaterals. A further preferred mass ratio is: 13.5-16.5 parts of Astragalus, 13.5-16.5 parts of Gleditsia sinensis, 11-13 parts of Red Peony Root, 13.5-16.5 parts of Rhodiola rosea, 9-11 parts of Angelica sinensis, and 2.8-3.2 parts of Panax notoginseng; a further optimized mass ratio is: 15 parts of Astragalus, 15 parts of Gleditsia sinensis, 12 parts of Red Peony Root, 15 parts of Rhodiola rosea, 10 parts of Angelica sinensis, and 3 parts of Panax notoginseng.

[0025] In actual use of this prescription, each weight portion above is 1g, which is the dosage per dose. Use 1 to 2 doses per day depending on the condition of the disease.

[0026] In a second aspect, the present invention also provides a method for preparing the above-mentioned Chinese medicine composition: weigh the raw materials according to the raw material ratio of the above-mentioned Chinese medicine composition, mix them, boil them with water, filter them, and obtain a decoction.

[0027] Preferably, the decoction is performed 1 to 2 times, each time for 30 to 45 minutes. Preferably, the decoction is performed 2 times, each time for 30 to 45 minutes.

[0028] In a third aspect, the present invention also provides another method for preparing the above-mentioned Chinese medicine composition: weigh each raw material according to the raw material ratio of the above-mentioned Chinese medicine composition, decoct with water, filter, concentrate and dry respectively to obtain the extract of each raw material obtained by the preparation method. The extract of each raw material obtained by the preparation method is easy to store and transport, and can be dispersed in water for clinical use.

[0029] Preferably, the decoction is performed 1 to 2 times, each time for 30 to 45 minutes. Preferably, the decoction is performed 2 times, each time for 30 to 45 minutes.

[0030] In a fourth aspect, the present invention also provides the use of the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method in the preparation of drugs for preventing and treating the recurrence and / or canceration of colorectal adenomas.

[0031] Preferably, the above-mentioned medicine is an oral preparation. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further illustrated in conjunction with specific embodiments below. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0033] The stir-fried Atractylodes lancea, Coix seeds, Oldenlandia diffusa, Pseudostellaria heterophylla, Curcuma zedoaria, Citron, and Herba Euphorbiae used in the following examples all meet national or local standards.

[0034] Example 1

[0035] The embodiment of the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. Each dose is prepared from the following raw materials by weight: 15g of stir-fried atractylodes lancea, 30g of coix seed, 15g of oldenlandia diffusa, 15g of pseudostellaria, 9g of vinegar-curcuma, 9g of citron and 15g of herba euphorbiae.

[0036] Preparation method:

[0037] Mix the above raw materials and place them in a medicine decoction machine, add 900g of water and boil for 45min, filter, boil the residue with 600g of water for 30min, filter, and combine the filtrate to obtain the product.

[0038] Example 2

[0039] The embodiment of the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. Each dose is prepared from the following raw materials by weight: 15g of stir-fried atractylodes lancea, 30g of coix seed, 15g of oldenlandia diffusa, 15g of pseudostellaria, 9g of vinegar-curcuma, 9g of citron and 15g of herba euphorbiae.

[0040] Preparation method:

[0041] The above raw materials were decocted with water for 2 times, the first time for 45 minutes, the residue was filtered and decocted again for 30 minutes, filtered, the filtrate was combined, concentrated and dried to obtain the decoction extracts of each raw material. The decoction extracts obtained were mixed to obtain the product.

[0042] Example 3

[0043] The embodiment of the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. Each dose is prepared from the following raw materials by weight: 14g of stir-fried atractylodes lancea, 28g of coix seed, 14g of oldenlandia diffusa, 14g of pseudostellaria, 6g of vinegar-cured zedoaria, 8g of citron and 14g of herba euphorbiae.

[0044] Preparation method:

[0045] Mix the above raw materials and place them in a medicine decoction machine, add 900g of water and boil for 45min, filter, boil the residue with 600g of water for 30min, filter, and combine the filtrate to obtain the product.

[0046] Example 4

[0047] The embodiment of the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. Each dose is prepared from the following raw materials by weight: 16g of stir-fried atractylodes lancea, 31g of coix seed, 16g of oldenlandia diffusa, 16g of pseudostellaria, 10g of vinegar-cured zedoaria, 10g of citron and 16g of euphorbia pulex.

[0048] The preparation method is the same as Example 2.

[0049] Example 5

[0050] The embodiment of the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. Each dose is prepared from the following raw materials by weight: 12g of stir-fried atractylodes lancea, 27g of coix seed, 12g of oldenlandia diffusa, 12g of pseudostellaria, 6g of vinegar-cured zedoaria, 6g of citron and 12g of herba euphorbiae.

[0051] Preparation method:

[0052] Mix the above raw materials and place them in a medicine decoction machine, add 800g of water and boil for 45min, filter, boil the residue with 500g of water for 30min, filter, and combine the filtrate to obtain the product.

[0053] Example 6

[0054] The embodiment of the present invention provides a traditional Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma. Each dose is prepared from the following raw materials by weight: 18g of stir-fried atractylodes lancea, 33g of coix seed, 18g of oldenlandia diffusa, 18g of pseudostellaria, 10g of vinegar-cured zedoaria, 10g of citron and 18g of herba euphorbiae.

[0055] The preparation method is the same as Example 2.

[0056] Effect Example 1

[0057] This effect example provides the statistical results of the clinical application effect of the Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma in Example 1 of the present invention.

[0058] Statistical objects: 200 patients who underwent postoperative clamp removal of colorectal adenomas in the outpatient and inpatient departments of the Department of Gastroenterology of Hebei Provincial Hospital of Traditional Chinese Medicine from 2019 to 2021. All 200 cases were treated with the Chinese medicine composition provided in Example 1 of the present invention, with a dosage of 1 dose per day, twice a day, morning and evening, for 3 months of treatment. The adenoma recurrence rate of the 200 patients was 43% (a total of 86 recurrences).

[0059] Effect Example 2

[0060] This effect example provides the statistical results of the clinical application effect of the Chinese medicine composition for preventing and treating the recurrence and canceration of colorectal adenoma in Example 2 of the present invention.

[0061] 1. Case source

[0062] From January to December 2022, 70 patients with colorectal adenoma who visited Hebei Provincial Hospital of Traditional Chinese Medicine were aged between 18 and 65 years old. All patients had varying degrees of abdominal distension, abdominal pain, constipation or diarrhea, belching, dry mouth, bitter taste in the mouth, anal distension and discomfort.

[0063] 2. Treatment methods

[0064] The 35 cases in the treatment group were orally administered the Chinese medicine composition of Example 2 of the present invention, one dose per day, after endoscopic adenoma removal.

[0065] There were 35 cases in the blank control group who voluntarily refused to accept drug intervention after endoscopic adenoma resection.

[0066] Patients in both groups filled out the TCM syndrome scale (as shown in Table 1), calculated the TCM syndrome scores, received health guidance, and were followed up for 1 year.

[0067] Table 1 TCM syndrome scale

[0068]

[0069] With reference to the Guiding Principles for Clinical Research of New Chinese Medicines (Trial Implementation), the nimodipine method was used to calculate the syndrome score reduction rate: syndrome score reduction rate = [(score before treatment - score after treatment) / score before treatment] × 100%.

[0070] The efficacy evaluation was conducted according to the TCM Clinical Efficacy Standard (ZY / T001.1-94) for the efficacy evaluation of polyps and hemorrhoids:

[0071] Cured: The frequency and characteristics of stools return to normal, symptoms and signs disappear or almost disappear, and the syndrome score decreases by more than 95% compared with that before treatment;

[0072] Markedly effective: The frequency of bowel movements has not been significantly reduced but the stool has become formed, or the stool is loose but occurs once a day, and the symptom score is reduced by more than 70% compared with before treatment;

[0073] Effective: The frequency and characteristics of stools are improved compared with before treatment, and the symptom score is reduced by more than 35% compared with before treatment;

[0074] Ineffective: The therapeutic effect does not reach the effective standard or the symptoms are worse than before.

[0075] Total effective rate = (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0076] 3. Results

[0077] The results are shown in Table 2 and Table 3:

[0078] Table 2 Comparison of polyp recurrence between the two groups one year after surgery

[0079] Group Number of cases relapse No recurrence Relapse rate Treatment Group 35 18 17 51.42％ Blank control group 35 21 14 60％

[0080] Table 3 Evaluation of TCM syndrome efficacy

[0081] Group Number of cases cure Significant effect efficient invalid Total Effectiveness Treatment Group 35 cases 2 20 9 4 88.57％ Blank control group 35 cases 0 9 14 12 65.71％

[0082] Effect Example 2

[0083] This effect example provides individual cases of clinical application of the Chinese medicine composition for preventing and treating recurrence and canceration of colorectal adenoma in Example 1 of the present invention.

[0084] Case 1:

[0085] Zhang, female, 58 years old;

[0086] Chief complaint: intermittent abdominal distension and pain for half a year;

[0087] Current main symptoms: intermittent abdominal pain, abdominal distension, difficult flatulence, sticky mouth, normal appetite, early satiety, occasional belching, normal sleep at night, frequent dreams and easy awakening, sticky and uncomfortable stools, one bowel movement every 1-2 days, yellow urine, dark red tongue with yellow greasy coating at the root, and a wiry and slippery pulse.

[0088] Auxiliary examination: On September 25, 2022, the results of the colonoscopy at Hebei Provincial Hospital of Traditional Chinese Medicine showed: colon polyps, polyps with a diameter of about 0.3 cm (already removed); proctitis. Pathology showed: (colon) low-grade tubular adenoma.

[0089] TCM diagnosis: abdominal pain caused by internal accumulation of turbid toxins

[0090] Western medicine diagnosis: 1. Adenomatous polyposis 2. Proctitis

[0091] On September 27, 2022, he first visited Hebei Provincial Hospital of Traditional Chinese Medicine and began to take Chinese medicine preparations: 6g of Bupleurum chinense, 10g of White Peony Root, 15g of Radix Pseudostellariae, 6g of Rhizoma Atractylodis Macrocephalae with Glutinous Rice Glutinosa, 10g of Citrus Hand, 10g of Tangerine Peel, 10g of Litchi Seed, 10g of Precocious Seed, 10g of Charred Crataegus Pinellia, 10g of Charred Shenqu, 10g of Charred Malt, 30g of Coix Seed, 15g of Hedyotis Diffusa, 9g of Curcuma Atractylodes with Vinegar, 6g of Amomum Villosum, 15g of Herba Dijincao, 20g of Dragon Bone, 20g of Oyster, and 20g of Fried Semen Ziziphi Spinosae (the above is the dosage per dose, calculated in terms of crude drugs; weigh the decoction-free granules of each Chinese medicine according to the weight ratio of the crude drugs, mix them together and take them with boiled water, and take 1 dose per day);

[0092] Re-examination on October 13, 2022. Current main symptoms: intermittent abdominal pain, abdominal distension, less flatulence, sticky mouth, normal appetite, early satiety, occasional belching, dreamy sleep and easy awakening at night, slightly improved, sticky and uncomfortable stool, one bowel movement per day, yellow urine, dark red tongue, thin yellow greasy coating, and slippery pulse.

[0093] The prescription was adjusted to: 6g of Bupleurum chinense, 10g of White Peony Root, 15g of Radix Pseudostellariae, 15g of Rhizoma Atractylodis Macrocephalae with Braised Glutinous Rice Bran, 10g of Citrus Hand, 10g of Tangerine Peel, 10g of Charred Crataegus Pinellia, 10g of Charred Shenqu, 10g of Charred Malt, 30g of Coix Seed, 15g of Hedyotis Diffusa, 9g of Curcuma Atractylodes with Vinegar, 6g of Amomum Villosum, 15g of Herba Dichroae, 20g of Dragon Bone, 20g of Oyster, 20g of Rhizoma Ziziphi Spinosae, 6g of Ginger, and 10g of Gleditsia sinensis (the above is the dosage per dose, calculated in terms of crude drugs; weigh the decoction-free granules of each Chinese medicine according to the weight ratio of the crude drugs, mix them together and take them with boiled water, and take 1 dose per day);

[0094] The third visit was on October 27, 2022. Current main symptoms: intermittent abdominal pain has been relieved, abdominal distension, sticky mouth, good appetite, early satiety, occasional belching, sleepiness with frequent dreams and easy awakening, slightly improved, sticky and uncomfortable stool, one bowel movement per day, yellow urine, dark red tongue, thin yellow greasy coating, and a stringy and slippery pulse.

[0095] The prescription was adjusted to: 6g of Bupleurum chinense, 10g of white peony root, 10g of stir-fried immature bitter orange with bran, 10g of vinegar-soaked cyperus, 10g of dried orange peel, 10g of citrus hand, 10g of charred hawthorn, 10g of charred Shenqu, 10g of charred malt, 30g of coix seed, 15g of oldenlandia diffusa, 9g of vinegar-soaked Curcuma, 6g of Amomum villosum, 15g of Fritillaria thunbergii, 20g of dragon bone, 20g of oyster, 20g of stir-fried spiny jujube seed, 6g of ginger, 10g of Gleditsia sinensis, 15g of stir-fried atractylodes with bran, 6g of siler, and 15g of euphorbia pulex (the above is the dosage per dose, calculated in terms of crude drugs; weigh the decoction-free granules of each Chinese medicine according to the weight ratio of the crude drugs, take them with boiled water after compatibility, and take 1 dose per day);

[0096] Fourth visit on November 14, 2022. Current main symptoms: Abdominal pain is significantly relieved, abdominal distension is relieved, sticky mouth is improved, appetite is good, occasional belching, sleep is improved with frequent dreams and easy awakening, bowel movements are one time a day, unformed, yellow urine, dark red tongue, thin yellow fur, and a stringy and slippery pulse.

[0097] The prescription was adjusted to: 6g of Bupleurum chinense, 10g of white peony root, 10g of stir-fried immature bitter orange with bran, 10g of vinegar-sweetened cyperus, 10g of dried orange peel, 10g of citrus hand, 10g of charred hawthorn, 10g of charred Shenqu, 10g of charred malt, 30g of coix seed, 15g of oldenlandia diffusa, 9g of vinegar-sweetened zedoaria, 6g of Amomum villosum, 15g of Fritillaria thunbergii, 20g of dragon bone, 20g of oyster, 20g of stir-fried spiny jujube seed, 6g of ginger, 10g of Gleditsia sinensis, 15g of stir-fried atractylodes with bran, 6g of siler, and 15g of Pseudostellaria heterophylla (the above is the dosage per dose, calculated in terms of crude drugs; weigh the decoction-free granules of each Chinese medicine according to the weight ratio of the crude drugs, take them with boiled water after compatibility, and take 1 dose per day);

[0098] Fifth visit on December 25, 2022. Current main symptoms: no obvious abdominal pain, occasional abdominal distension, improved sticky mouth, good appetite, occasional belching, good sleep at night, one bowel movement a day, unformed, yellow urine, dark red tongue, thin yellow fur, and a stringy and slippery pulse.

[0099] The adjusted prescription is: 6g of Northern Bupleurum, 10g of White Peony, 10g of Stir-fried Citrus aurantium with bran, 10g of Vinegar Cyperus, 10g of Tangerine Peel, 10g of Citrus Palm, 10g of Charred Crataegus, 10g of Charred Shenqu, 10g of Charred Malt, 30g of Coix Seed, 15g of Oldenlandia Diffusa, 9g of Vinegar Curcuma, 6g of Amomum, 15g of Fritillaria Thunbergii, 20g of Dragon Bone, 20g of Oyster, 20g of Stir-fried Ziziphus jujuba seeds, 6g of Gleditsia sinensis, 10g of Stir-fried Atractylodes with bran, 6g of Saposhnikovia divaricata, and 15g of Pseudostellaria heterophylla (the above is the dosage per dose, calculated in terms of raw drugs; weigh the decoction-free granules of each Chinese medicine according to the weight ratio of the raw drugs, take it with boiled water after matching, and take 1 dose per day).

[0100] Efficacy: On March 15, 2023, the colonoscopy results showed chronic colorectal inflammation, no ulcers or neoplasms were found.

[0101] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modification, equivalent substitution or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for preventing and treating colorectal adenoma recurrence and canceration, characterized in that: The raw materials of the traditional Chinese medicine composition are: 12-18g of stir-fried atractylodes lancea with bran, 27-33g of coix seeds, 12-18g of oldenlandia diffusa, 12-18g of pseudoginseng, 6-10g of vinegar-curdled zedoaria, 6-10g of citron and 12-18g of euphorbia pulex.

2. The Chinese medicine composition according to claim 1, characterized in that: The raw materials of the traditional Chinese medicine composition are: 14-16g of stir-fried atractylodes lancea with bran, 28-31g of coix seed, 14-16g of oldenlandia diffusa, 14-16g of pseudoginseng, 6-10g of vinegar-curd zedoaria, 8-10g of citron and 14-16g of euphorbia pulex.

3. The Chinese medicine composition according to claim 2, characterized in that: The raw materials of the traditional Chinese medicine composition are: 15g of stir-fried atractylodes with bran, 30g of coix seed, 15g of oldenlandia diffusa, 15g of pseudostellaria, 9g of vinegar-curdled zedoaria, 9g of citron and 15g of herba euphorbiae.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The raw materials are weighed according to the raw material ratio of the traditional Chinese medicine composition, mixed, boiled with water, filtered, and obtained a decoction.

5. The preparation method according to claim 4, characterized in that: The decoction is performed 1 to 2 times, each time for 30 to 45 minutes.

6. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The raw materials are weighed according to the raw material ratio of the traditional Chinese medicine composition, and are decocted with water, filtered, concentrated and dried respectively to obtain the traditional Chinese medicine composition.

7. The preparation method according to claim 6, characterized in that: The decoction is performed 1 to 2 times, each time for 30 to 45 minutes.

8. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 7 in the preparation of drugs for preventing and treating recurrence and / or canceration of colorectal adenoma.

9. The use according to claim 8, characterized in that: The medicine is an oral preparation.

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