A lipid-lowering and weight-loss composition, a lipid-lowering and weight-loss product and a preparation method thereof

Abstract

The invention discloses a lipid-lowering and weight-loss composition, a lipid-lowering and weight-loss product and a preparation method thereof, and belongs to the technical field of food and medicine. By weight, the lipid-lowering and weight-loss composition includes 3-6 parts of black dates, 1.8-6 parts of raw coix seeds, 1.8-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.4 parts of polygonatum and 0.6-2 parts of lotus leaves. The lipid-lowering and weight-loss composition is suitable for obese people with increased blood lipids caused by internal damp-heat accumulation, and can play the role of clearing heat and removing dampness, reducing blood lipids and losing weight. The lipid-lowering and weight-loss product containing the above-mentioned lipid-lowering and weight-loss composition can also play the role of clearing heat and removing dampness, reducing blood lipids and losing weight for obese people with increased blood lipids caused by internal damp-heat accumulation. The corresponding preparation method is simple, easy to operate, and suitable for industrial production.

Description

Technical Field

[0001] The present invention relates to the technical field of food and medicine, and in particular to a lipid-lowering and weight-loss composition, a lipid-lowering and weight-loss product and a preparation method thereof. Background Art

[0002] Obesity refers to excessive accumulation and / or abnormal distribution of body fat and weight gain. It is a chronic metabolic disease caused by the interaction of multiple factors, including genetic and environmental factors. Obesity is closely related to a variety of diseases such as type II diabetes, dyslipidemia, hypertension, coronary heart disease and certain cancers. Obesity and related diseases may damage the physical and mental health of patients and reduce their quality of life. With the increasing incidence of obesity and hyperlipidemia and the trend of younger people, providing products that can play a certain role in reducing fat and weight has become a hot topic.

[0003] In view of this, the present invention is proposed. Summary of the invention

[0004] One of the purposes of the present invention is to provide a lipid-lowering and weight-loss composition, which is suitable for obese people with increased blood lipids caused by internal dampness and heat, and can play the role of clearing away heat and dampness, lowering lipids and losing weight.

[0005] The second object of the present invention is to provide a lipid-lowering and weight-loss product whose preparation raw materials include the lipid-lowering and weight-loss composition.

[0006] The third object of the present invention is to provide a method for preparing the above-mentioned lipid-lowering and weight-loss product.

[0007] This application can be implemented as follows:

[0008] In a first aspect, the present application provides a lipid-lowering and weight-loss composition, which comprises, by weight, 3-6 parts of black dates, 1.8-6 parts of raw coix seeds, 1.8-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.4 parts of polygonatum and 0.6-2 parts of lotus leaves.

[0009] In an optional embodiment, the lipid-lowering and weight-loss composition includes 3-6 parts of black dates, 3-6 parts of raw coix seeds, 2-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.2 parts of polygonatum and 1-2 parts of lotus leaves.

[0010] In an optional embodiment, the lipid-lowering and weight-loss composition includes 5 parts of black dates, 3 parts of raw coix seeds, 3 parts of raw cassia seeds, 3 parts of red beans, 3 parts of black sesame seeds, 2 parts of polygonatum and 1 part of lotus leaves.

[0011] In a second aspect, the present application provides a lipid-lowering and weight-loss product, the raw materials for preparing the lipid-lowering and weight-loss composition include any one of the aforementioned embodiments.

[0012] In an optional embodiment, the lipid-lowering and weight-loss product includes a lipid-lowering and weight-loss food or a lipid-lowering and weight-loss medicine.

[0013] In an optional embodiment, when the lipid-lowering and weight-loss product is a lipid-lowering and weight-loss food, the preparation raw materials further include seasonings and / or food additives.

[0014] In a third aspect, the present application provides a method for preparing the lipid-lowering and weight-loss product according to the aforementioned embodiment, comprising the following steps: extracting the preparation raw materials.

[0015] In an optional embodiment, before extraction, the process further includes crushing or mashing raw cassia seed, black sesame, raw coix seed and adzuki bean.

[0016] In an optional embodiment, the extraction is performed by soaking the prepared raw material in water and then heating it under reflux for extraction.

[0017] In an optional embodiment, the material-liquid ratio of the prepared raw material to the water used for soaking is 1 g: 5-15 mL.

[0018] In an optional embodiment, the soaking time is 0.5-2h.

[0019] In an optional embodiment, the temperature of the heating reflux extraction is 80-100°C.

[0020] In an optional embodiment, the heating reflux extraction is performed 1-3 times, and the time of each heating reflux extraction is 0.5-2h.

[0021] In an optional embodiment, the method further includes separating the solid-liquid extract after extraction, and drying the separated liquid phase.

[0022] In an optional embodiment, the extract is further cooled before solid-liquid separation.

[0023] In an alternative embodiment, cooling is to 20-50°C.

[0024] In an optional embodiment, solid-liquid separation is performed by combining centrifugation and sieve filtration, wherein the mesh size of the sieve is 100-300 meshes.

[0025] In an optional embodiment, drying comprises any one of vacuum drying, forced air drying, freeze drying and spray drying.

[0026] In an optional embodiment, the vacuum drying temperature is 50-80°C.

[0027] In an optional embodiment, the temperature of the forced air drying is 60-100°C.

[0028] In an optional embodiment, the pre-freezing temperature of freeze drying is -40 to -20°C, the sublimation temperature is -20 to 25°C, and the decomposition temperature is 25 to 55°C.

[0029] In an optional embodiment, the inlet air temperature of the spray drying is 120-210°C, and the outlet air temperature is 60-110°C.

[0030] In an optional embodiment, the liquid phase is concentrated before drying.

[0031] In an optional embodiment, the concentration is carried out by concentration under reduced pressure.

[0032] In an optional embodiment, the reduced pressure concentration is carried out at 60-80° C. and a vacuum degree of -0.07 to -0.10 MPa.

[0033] In an optional embodiment, the solid content of the concentrated liquid phase is 10-20%.

[0034] In an optional embodiment, the method further comprises screening the dried product.

[0035] In an optional embodiment, the mesh size of the sieve used for sieving is 60-100 meshes, preferably 80 meshes.

[0036] The beneficial effects of this application include:

[0037] In the lipid-lowering and weight-loss composition provided in the present application, raw coix seed is used as the main medicine, raw coix seed is cool in nature, sweet and light in taste, and enters the spleen, stomach, and lung meridians, and can strengthen the spleen and lung, clear away heat and dampness. Raw cassia seed and lotus leaf are used as ministerial medicines, among which raw cassia seed is slightly cold in nature, sweet and bitter in taste, enters the liver meridian and large intestine meridian, clears liver fire and has the function of evacuation, and has the effect of moistening the intestine, lowering serum cholesterol and lowering blood pressure; lotus leaf is flat in nature, bitter in taste, enters the liver, spleen, and stomach meridians, and has the effects of clearing away heat and dampness, promoting clear yang, cooling blood and stopping bleeding. Red bean, black date and black sesame are used as adjuvants, which can promote diuresis, strengthen the kidney and relieve constipation. Polygonatum odoratum is used as a messenger to prevent excessive loss of body fluid in the body. All medicines are used together to play the effects of clearing away heat and dampness, strengthening the spleen and lightening the body, and reducing weight and reducing fat, and are particularly suitable for obese people with increased blood lipids caused by internal damp heat. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0039] The lipid-lowering and weight-loss composition, lipid-lowering and weight-loss product and preparation method thereof provided in the present application are described in detail below.

[0040] The present application proposes a lipid-lowering and weight-loss composition, which comprises, by weight, 3-6 parts of black dates, 1.8-6 parts of raw coix seeds, 1.8-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.4 parts of polygonatum and 0.6-2 parts of lotus leaves.

[0041] For reference, the amount of black dates can be 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, 4.8 parts, 5 parts, 5.2 parts, 5.5 parts, 5.8 parts or 6 parts, etc., or any other value within the range of 3-6 parts.

[0042] The dosage of raw coix seed can be 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, 4.8 parts, 5 parts, 5.2 parts, 5.5 parts, 5.8 parts or 6 parts, etc., or it can be any other value within the range of 1.8-6 parts.

[0043] The dosage of raw Cassia seeds can be 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts or 3 parts, etc., or any other value within the range of 1.8-3 parts.

[0044] The amount of adzuki bean can be 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, 4.8 parts, 5 parts, 5.2 parts, 5.5 parts, 5.8 parts or 6 parts, etc., or any other value within the range of 1.8-6 parts.

[0045] The amount of black sesame can be 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts or 3 parts, etc., or any other value within the range of 1.8-3 parts.

[0046] The dosage of Polygonatum odoratum can be 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts or 2.4 parts, etc., or any other value within the range of 1.2-2.4 parts.

[0047] The amount of lotus leaf can be 0.6 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts or 2 parts, etc., or any other value within the range of 0.6-2 parts.

[0048] In some preferred embodiments, the lipid-lowering and weight-loss composition includes 3-6 parts of black dates, 3-6 parts of raw coix seeds, 2-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.2 parts of polygonatum and 1-2 parts of lotus leaves.

[0049] In some more preferred embodiments, the lipid-lowering and weight-loss composition includes 5 parts of black dates, 3 parts of raw coix seeds, 3 parts of raw cassia seeds, 3 parts of red beans, 3 parts of black sesame seeds, 2 parts of polygonatum and 1 part of lotus leaves.

[0050] Each component in the above composition can be a medicinal material or a medicinal piece.

[0051] The lipid-lowering and weight-loss composition provided in the present application is particularly suitable for obese people with increased blood lipids caused by internal damp-heat accumulation. It is mainly used to treat damp-heat stasis and constipation, and can play the role of clearing away heat and dampness and lowering lipids and losing weight.

[0052] Specifically, in the above composition, raw coix seed is used as the main medicine, which is cool in nature, sweet and light in taste, and enters the spleen, stomach, and lung meridians, and can strengthen the spleen and lung, clear away heat and dampness. Raw cassia seed and lotus leaf are used as the ministerial medicine, among which raw cassia seed is slightly cold in nature, sweet and bitter in taste, enters the liver meridian and large intestine meridian, clears liver fire and has the function of evacuation, and has the effect of moistening the intestine, lowering serum cholesterol and lowering blood pressure; lotus leaf is flat in nature, bitter in taste, enters the liver, spleen, and stomach meridians, and has the effects of clearing away heat and dampness, promoting the clear yang, cooling blood and stopping bleeding. Red bean, black date and black sesame are used as adjuvants, which can promote diuresis, strengthen the kidney and relieve constipation. Polygonatum odoratum is used as the messenger to prevent excessive loss of body fluid in the body. All the medicines are used together to play the effects of clearing away heat and dampness, strengthening the spleen and lightening the body, and reducing weight and reducing blood lipids.

[0053] Furthermore, the present application also provides a lipid-lowering and weight-loss product, the raw materials for preparing the lipid-lowering and weight-loss composition include the above-mentioned lipid-lowering and weight-loss composition.

[0054] For reference, the above-mentioned lipid-lowering and weight-loss products may include lipid-lowering and weight-loss foods (including lipid-lowering and weight-loss health foods) or lipid-lowering and weight-loss medicines.

[0055] When the lipid-lowering and weight-loss product is a common lipid-lowering and weight-loss food or a health food, its preparation raw materials also include seasonings and / or food additives.

[0056] When the lipid-lowering and weight-loss product is a lipid-lowering and weight-loss health food or medicine, its preparation raw materials may also include pharmaceutically acceptable excipients and carriers.

[0057] Correspondingly, the present application also provides a method for preparing the above-mentioned lipid-lowering and weight-loss product, comprising the following steps: extracting the preparation raw materials.

[0058] For reference, the extraction may be performed by soaking the raw material in water and then heating it under reflux for extraction.

[0059] Among them, the material-liquid ratio of the prepared raw materials to the water used for soaking can be 1g:5-15mL, such as 1g:5mL, 1g:6mL, 1g:7mL, 1g:8mL, 1g:9mL, 1g:10mL, 1g:11mL, 1g:12mL, 1g:13mL, 1g:14mL or 1g:15mL, etc., or it can be any other value within the range of 1g:5-15mL.

[0060] The soaking time may be 0.5-2 h, such as 0.5 h, 0.8 h, 1 h, 1.2 h, 1.5 h, 1.8 h or 2 h, or any other value within the range of 0.5-2 h.

[0061] The temperature of the heating reflux extraction can be 80-100°C, such as 80°C, 85°C, 90°C, 95°C or 100°C, etc., or any other value within the range of 80-100°C.

[0062] The number of heating reflux extractions can be illustratively but not limitatively 1-3 times (such as 1, 2 or 3 times), and the time of each heating reflux extraction can be 0.5-2 h (such as 0.5 h, 1 h, 1.5 h or 2 h).

[0063] Through the above extraction process, the effective components in the preparation raw materials can be effectively extracted.

[0064] In some optional embodiments, before extraction, raw cassia seed, black sesame, raw coix seed and adzuki bean can be crushed or pounded to improve the extraction effect.

[0065] Furthermore, the solid-liquid separation of the extract after extraction is carried out, and the liquid phase obtained by separation is dried.

[0066] In some optional embodiments, before solid-liquid separation, the extract is further cooled, such as cooled to 20-50°C, such as 20°C, 25°C, 30°C, 35°C, 40°C, 45°C or 50°C, etc., or it can be cooled to any other value within the range of 20-50°C.

[0067] In an optional embodiment, solid-liquid separation is performed by combining centrifugation and sieve filtration, wherein the mesh size of the sieve is 100-300 meshes (preferably 200 meshes).

[0068] When the number of reflux extractions is greater than 2, the filter residue after the previous extraction is used as the extraction raw material for the next extraction, and the extract obtained from each reflux extraction is cooled, centrifuged, filtered, and the filtrate is combined for standby use.

[0069] In some specific embodiments, the extraction process can be carried out in the following manner: the components in the composition are mixed according to a ratio (wherein, raw cassia seed, black sesame, raw coix seed and red bean are first crushed and then mixed), and 8 times deionized water is added for immersion for 1 hour; then heated and refluxed for extraction at 100°C for 1 hour; the obtained extract is cooled to 40°C, centrifuged, and the supernatant of the centrifuge is filtered (200 mesh sieve) for later use; the filter residue is subjected to a second extraction under the same extraction conditions as the first extraction, and the extract is cooled to 40°C, centrifuged, and the supernatant of the centrifuge is filtered (200 mesh sieve) for later use, and the two filtrates are combined.

[0070] For reference, the drying in the present application may include any one of vacuum drying, forced air drying, freeze drying and spray drying.

[0071] When vacuum drying is adopted, the vacuum drying temperature can be 50-80°C, such as 50°C, 55°C, 60°C, 65°C, 70°C, 75°C or 80°C, etc., or any other value within the range of 50-80°C.

[0072] When air drying is adopted, the air drying temperature can be 60-100°C, such as 60°C, 65°C, 70°C, 75°C, 80°C, 85°C, 90°C, 95°C or 100°C, etc., or it can be any other value within the range of 60-100°C.

[0073] When freeze drying is adopted, the pre-freezing temperature of freeze drying can be -40 to -20°C, such as -40°C, -35°C, -30°C, -25°C, -20°C, etc., or any other value within the range of -40 to -20°C. The sublimation temperature can be -20 to 25°C, such as -20°C, -15°C, -10°C, -5°C, 0°C, 5°C, 10°C, 15°C, 20°C or 25°C, etc., or any other value within the range of -20 to 25°C. The decomposition temperature can be 25 to 55°C, such as 25°C, 30°C, 35°C, 40°C, 45°C, 50°C or 55°C, etc., or any other value within the range of 25 to 55°C.

[0074] When spray drying is adopted, the air inlet temperature of spray drying can be 120-210° C., such as 120° C., 130° C., 140° C., 150° C., 160° C., 170° C., 180° C., 190° C., 200° C. or 210° C., etc., or any other value within the range of 120-210° C. The air outlet temperature can be 60-110° C., such as 60° C., 65° C., 70° C., 75° C., 80° C., 85° C., 90° C., 95° C., 100° C., 105° C. or 110° C., etc., or any other value within the range of 60-110° C.

[0075] In some embodiments, before drying, the liquid phase is concentrated, which can be done by concentrating under reduced pressure.

[0076] Specifically, the reduced pressure concentration can be performed at 60-80° C. and a vacuum degree of -0.07 to -0.10 MPa. In some embodiments, the concentration is performed until the solid content of the liquid phase is 10-20%.

[0077] Furthermore, the dried product is sieved.

[0078] The mesh size of the sieve used for sieving can be 60-100 meshes, preferably 80 meshes.

[0079] In some specific embodiments, the filtrate after extraction and filtration can be concentrated under reduced pressure to a thick paste, transferred to an evaporating dish, vacuum dried or air dried to obtain an extract dry extract, and then the extract dry extract is crushed into powder, mixed evenly, and passed through an 80-mesh sieve. The filtrate after extraction and filtration can also be concentrated under reduced pressure to a certain volume, filtered, freeze-dried or spray-dried, and mixed evenly after drying, and passed through an 80-mesh sieve.

[0080] In the present application, the dry extract powder of the extract may not be seasoned and may be directly processed and packaged according to the formulation prescription; alternatively, corresponding seasonings and food additives may be added for seasoning according to taste requirements, and molding auxiliary materials may be added for processing, and after packaging, medicated vegetarian products of various flavors may be obtained, and the product form may be solid (powder, granules, blocks, tablets, capsules, pills, gel candy, jelly), liquid, paste, etc.

[0081] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0082] Example 1

[0083] This embodiment provides a lipid-lowering and weight-loss product, which is prepared by the following method:

[0084] Take 6 parts of black dates, 1.8 parts of raw coix seeds, 1.8 parts of raw cassia seeds, 6 parts of red beans, 3 parts of black sesame seeds, 2.4 parts of polygonatum and 0.6 parts of lotus leaves (all parts are by weight, based on dry weight), crush the raw coix seeds, raw cassia seeds, red beans and black sesame seeds, and then mix the above raw materials.

[0085] Deionized water was added at a solid-liquid ratio of 1:8 (g:mL), and the mixture was soaked for 1 hour. The extract was heated at 100°C and refluxed for 1 hour. The extract was cooled to 40°C, centrifuged, and filtered (200 mesh sieve) to obtain filtrate 1. 8 times the volume of water was added to the residue, and the extract was cooled to 40°C for 1 hour. The extract was cooled to 40°C, centrifuged, and filtered (200 mesh sieve) to obtain filtrate 2. After filtrates 1 and 2 were combined, they were concentrated under reduced pressure at a concentration temperature of 60°C and a vacuum degree of -0.09MPa. The mixture was concentrated to a solid content of 15%, filtered (200 mesh sieve), and then spray-dried. The air inlet temperature was 170°C and the air outlet temperature was 90°C. The spray-dried powder was sieved through an 80-mesh sieve to obtain the obtained formula 1.

[0086] Example 2

[0087] The difference between this embodiment and embodiment 1 is that:

[0088] The raw materials are: 3 parts of black dates, 6 parts of raw coix seeds, 3 parts of raw cassia seeds, 1.8 parts of red beans, 1.8 parts of black sesame seeds, 1.2 parts of polygonatum odoratum and 2 parts of lotus leaves. 2 groups of prescriptions were obtained.

[0089] Example 3

[0090] The difference between this embodiment and embodiment 1 is that:

[0091] The raw materials are: 5 parts of black dates, 3 parts of raw coix seeds, 3 parts of raw cassia seeds, 3 parts of red beans, 3 parts of black sesame seeds, 2 parts of polygonatum and 1 part of lotus leaves. Three groups of prescriptions were obtained.

[0092] Example 4

[0093] The difference between this embodiment and embodiment 1 is that:

[0094] The raw materials are: 6 parts of black dates, 6 parts of raw coix seeds, 3 parts of raw cassia seeds, 6 parts of red beans, 3 parts of black sesame seeds, 2.4 parts of polygonatum and 2 parts of lotus leaves. 4 groups of prescriptions were obtained.

[0095] Example 5

[0096] The difference between this embodiment and embodiment 1 is that:

[0097] The raw materials are: 5 parts of black dates, 2 parts of raw coix seeds, 2 parts of raw cassia seeds, 5 parts of red beans, 3 parts of black sesame seeds, 2.2 parts of polygonatum odoratum and 0.8 parts of lotus leaves. Five groups of prescriptions were obtained.

[0098] Example 6

[0099] The difference between this embodiment and embodiment 1 is that:

[0100] The raw materials are: 4 parts of black dates, 5 parts of raw coix seeds, 3 parts of raw cassia seeds, 2 parts of red beans, 2 parts of black sesame, 1.4 parts of polygonatum and 1.6 parts of lotus leaves. 6 groups of prescriptions were obtained.

[0101] Example 7

[0102] The difference between this embodiment and embodiment 3 is that the heating reflux extraction is carried out at 90° C. 7 groups of formulas are obtained.

[0103] Example 8

[0104] The difference between this embodiment and embodiment 3 is that before extraction, the raw coix seeds, raw cassia seeds, red beans and black sesame seeds were not crushed, but directly mixed. 8 groups of formulas were obtained.

[0105] Example 9

[0106] The difference between this embodiment and embodiment 3 is that the material-liquid ratio (g:mL) is 1:6. 9 groups of formulas were obtained.

[0107] Example 10

[0108] The difference between this embodiment and embodiment 3 is that the heating reflux extraction is performed once and the extraction time is 2 hours. 10 groups of formulas are obtained.

[0109] Embodiment 11

[0110] The difference between this embodiment and embodiment 3 is that:

[0111] The concentrated extract was transferred to an evaporating dish and dried with air at 95°C. The obtained dry extract was crushed and passed through an 80-mesh sieve to obtain 11 groups of formulas.

[0112] Comparative Example 1

[0113] The difference between this embodiment and embodiment 1 is that:

[0114] The raw materials are: 1.5 parts of black dates, 6.5 parts of raw coix seeds, 1 part of raw cassia seeds, 6.5 parts of red beans, 1 part of black sesame seeds, 3 parts of polygonatum odoratum and 0.5 parts of lotus leaves. 12 prescriptions were obtained.

[0115] Comparative Example 2

[0116] The difference between this embodiment and embodiment 1 is that:

[0117] The raw materials are: 6.5 parts of black dates, 1 part of raw coix seeds, 4 parts of raw cassia seeds, 1.5 parts of red beans, 3.5 parts of black sesame seeds, 1 part of polygonatum odoratum and 2.5 parts of lotus leaves. 13 prescriptions were obtained.

[0118] Comparative Example 3

[0119] The difference between this embodiment and embodiment 3 is that an equal amount of Poria cocos is used to replace raw coix seed. 14 groups of prescriptions are obtained.

[0120] Comparative Example 4

[0121] The difference between this embodiment and embodiment 3 is that an equal amount of senna leaves is used to replace raw cassia seeds. 15 prescriptions are obtained.

[0122] Comparative Example 5

[0123] The difference between this embodiment and embodiment 3 is that an equal amount of mung beans is used instead of adzuki beans. 16 prescriptions are obtained.

[0124] Comparative Example 6

[0125] The difference between this embodiment and embodiment 3 is that an equal amount of Dendrobium officinale is used to replace Polygonatum odoratum. 17 prescriptions are obtained.

[0126] Test Example 1

[0127] Study on the lipid-lowering and weight-loss effects of lipid-lowering and weight-loss products on mice fed a high-fat diet

[0128] 1. Implementation methods

[0129] The extracts of Formulation 1, Formulation 2, Formulation 3, Formulation 4, Formulation 5, Formulation 6, Formulation 12 and Formulation 13 corresponding to Examples 1-6 and Comparative Examples 1-2 were used as test samples. 100 male 7-week-old SPF-grade C57BL / 6 mice were purchased from China Food and Drug Inspection Institute (Daxing), license number: SCXK (Beijing) 2017-0005, and were raised in the SPF-grade experimental animal center of the School of Life Sciences of Beijing Institute of Technology, with a 12-hour day and night cycle, a temperature of (22±2)°C, and a humidity of 50±5%. All animals were free to eat and drink.

[0130] The mice were adaptively fed for 7 days before the experiment and randomly divided into normal control group, model control group, group 1, group 2, group 3, group 4, group 5, group 6, group 12 and group 13 according to body weight, with 10 mice in each group. The normal control group was given ordinary feed, and each drug-treated group and the model control group were fed with high-fat feed. The normal control group and the model control group were gavaged with equal volume of solvent control, and the mice in each drug-treated group were gavaged (dosage calculation: the amount of crude drug for human use in each formula is 100g / day, multiplied by the extraction rate of each formula for the human use of each formula, and the human body weight is calculated as 70kg. The dosage of mice was determined according to the equivalent dose conversion requirements between humans and animals in "Pharmacological Experimental Methodology"), and the gavage volume was 0.1mL / 10g body weight. Drink water and eat normally, and the model was continuously modeled and gavage was administered for 6 weeks. During the administration, the survival status of mice in each group was observed, and the body weight, water intake, and food intake were weighed. At the end of the administration, the body length of the mice was measured and the Lee's index was calculated according to formula (1). Blood was collected to detect the levels of cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). The liver and fat were removed by dissection, and the liver and fat weights were weighed. The liver coefficient and fat coefficient were calculated according to formula (2) and formula (3).

[0131]

[0132]

[0133]

[0134] 2. Experimental results

[0135] ① The weight changes and Lee's index results of mice in each group are shown in Table 1.

[0136] Table 1 Body weight changes and Lee's index results of mice in each group

[0137]

[0138] Note: Compared with the normal control group, *P<0.05, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0139] The results showed that after 6 weeks of oral administration, the body weight of mice in each group increased to varying degrees. The body weight of mice in the model control group was significantly higher than that in the normal control group at week 6 (P<0.01), and that in groups 1, 2, 3, 4, 5 and 6 was significantly lower than that in the model control group (P<0.05 or P<0.01). The results of Lee's index showed that the body weight of mice in the model control group was significantly higher than that in the normal control group (P<0.05), and that in groups 1, 2, 3, 4, 5 and 6 was significantly lower than that in the model control group (P<0.05 or P<0.01). The effects of groups 12 and 13 were not obvious.

[0140] The comprehensive results showed that groups 1-6 were all effective, among which group 3 had the best effect.

[0141] ②The results of the four blood lipids of each group of mice are shown in Table 2.

[0142] Table 2 Effects of each group on four indicators of blood lipids in mice

[0143]

[0144] Note: Compared with the normal control group, *P<0.05, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0145] The results showed that the blood TC, TG, and LDL-C levels of mice in the model control group were significantly higher than those in the normal control group (P<0.01), and the HDL-C level was significantly lower than that in the normal control group (P<0.01), which fully proved that this experiment provided a hyperlipidemia model. The four blood lipid results of Group 3 and Group 6 were all significantly better than those of the model control group (P<0.05 or P<0.01), and Group 1, Group 2, Group 4, and Group 5 all had different degrees of improvement effects (P<0.05 or P<0.01). The effects of Group 12 and Group 13 were not obvious.

[0146] ③The liver coefficient and fat coefficient results of each group of mice are shown in Table 3.

[0147] Table 3 Effects of each group on liver coefficient and fat coefficient of mice

[0148]

[0149]

[0150] Note: Compared with the normal control group, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0151] The results showed that the liver coefficient and fat coefficient of the mice in the model control group were significantly higher than those in the normal control group (P<0.01), which once again proved that this experiment provided a high-fat model. Group 1, Group 2, Group 3, Group 4, Group 5, and Group 6 all had different degrees of improvement effects (P<0.05 or P<0.01), among which Group 3 was the best (P<0.01). Group 12 and Group 13 had no obvious effects.

[0152] Test Example 2

[0153] Study on the lipid-lowering and weight-loss effects of lipid-lowering and weight-loss products on mice fed a high-fat diet

[0154] 1. Implementation Method Referring to Test Example 1, the efficacy of the products provided in Example 3 and Examples 7-11 (Examples 7-11 correspond to the following formulation groups 7 to 11, respectively) was investigated.

[0155] 2. Experimental results:

[0156] The weight changes and Lee's index results of each group of mice are shown in Table 4, the four blood lipid results of each group of mice are shown in Table 5, and the liver coefficient and fat coefficient results of each group of mice are shown in Table 6.

[0157] Table 4 Body weight changes and Lee's index results of mice in each group

[0158]

[0159] Note: Compared with the normal control group, *P<0.05, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0160] Table 5 Effects of each group on four indicators of blood lipids in mice

[0161]

[0162]

[0163] Note: Compared with the normal control group, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0164] Table 6 Effects of each group on the liver coefficient and fat coefficient of mice

[0165]

[0166] Note: Compared with the normal control group, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0167] The results showed that the weight, Lee's index, blood lipid index, liver index and kidney index of the three groups of Chinese medicine combination were significantly better than those of the model control group (P<0.01), and the other groups had different degrees of improvement (P<0.05 or P<0.01). This shows that the preparation conditions corresponding to the three groups of prescriptions can obtain products with better effects.

[0168] Test Example 3

[0169] Study on the lipid-lowering and weight-loss effects of lipid-lowering and weight-loss products on mice fed a high-fat diet

[0170] 1. Implementation Method Referring to Test Example 1, the efficacy of the products provided in Example 3 and Comparative Examples 3-6 (Comparative Examples 3-6 correspond to the following formulations 14 to 17, respectively) was investigated.

[0171] 2. Experimental results:

[0172] The weight changes and Lee's index results of each group of mice are shown in Table 7, the four blood lipid results of each group of mice are shown in Table 8, and the liver coefficient and fat coefficient results of each group of mice are shown in Table 9.

[0173] Table 7 Body weight changes and Lee's index results of mice in each group

[0174]

[0175] Note: Compared with the normal control group, *P<0.05, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0176] Table 8 Effects of each group on four indicators of blood lipids in mice

[0177]

[0178] Note: Compared with the normal control group, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0179] Table 9 Effects of each group on the liver coefficient and fat coefficient of mice

[0180]

[0181] Note: Compared with the normal control group, **P<0.01; compared with the model control group, #P<0.05, ##P<0.01.

[0182] The results showed that the body weight, Lee's index, blood lipid index, liver index and kidney index of group 3 were significantly better than those of the model control group (P<0.05 or P<0.01), and the other groups showed different degrees of improvement, but the effect was not obvious.

[0183] In summary, the lipid-lowering and weight-loss composition provided in the present application can effectively play the role of lipid-lowering and weight-loss.

[0184] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A lipid-lowering and weight-loss composition, characterized in that: The lipid-lowering and weight-loss composition consists of 3-6 parts of black dates, 1.8-6 parts of raw coix seeds, 1.8-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.4 parts of polygonatum and 0.6-2 parts of lotus leaves by weight.

2. The lipid-lowering and weight-loss composition according to claim 1, characterized in that: The lipid-lowering and weight-loss composition consists of 3-6 parts of black dates, 3-6 parts of raw coix seeds, 2-3 parts of raw cassia seeds, 1.8-6 parts of red beans, 1.8-3 parts of black sesame seeds, 1.2-2.2 parts of polygonatum odoratum and 1-2 parts of lotus leaves.

3. The lipid-lowering and weight-loss composition according to claim 2, characterized in that: The lipid-lowering and weight-loss composition consists of 5 parts of black dates, 3 parts of raw coix seeds, 3 parts of raw cassia seeds, 3 parts of red beans, 3 parts of black sesame seeds, 2 parts of polygonatum odoratum and 1 part of lotus leaves.

4. A lipid-lowering and weight-loss product, characterized in that: The raw materials for preparing the lipid-lowering and weight-loss product include the lipid-lowering and weight-loss composition according to any one of claims 1 to 3; The lipid-lowering and weight-loss product is a lipid-lowering and weight-loss medicine.

5. The method for preparing the lipid-lowering and weight-loss product according to claim 4, characterized in that: The following steps are involved: The preparation raw material is extracted.

6. The preparation method according to claim 5, characterized in that: Before extraction, the method further comprises crushing or mashing the raw cassia seed, the black sesame, the raw coix seed and the red bean.

7. The preparation method according to claim 6, characterized in that: The extraction is performed by soaking the raw materials in water and then heating and refluxing for extraction.

8. The preparation method according to claim 7, characterized in that: The material-liquid ratio of the prepared raw material to the water used for soaking is 1g:5-15mL.

9. The preparation method according to claim 7, characterized in that: The soaking time is 0.5-2h.

10. The preparation method according to claim 7, characterized in that: The temperature of the heating reflux extraction is 80-100°C.

11. The preparation method according to claim 7, characterized in that: The number of heating reflux extractions is 1-3 times, and the time of each heating reflux extraction is 0.5-2h.

12. The preparation method according to any one of claims 7 to 11, characterized in that: The method also includes separating the solid and liquid of the extracted liquid and drying the separated liquid phase.

13. The preparation method according to claim 12, characterized in that: Before solid-liquid separation, the extract is cooled.

14. The preparation method according to claim 13, characterized in that: Cool to 20-50°C.

15. The preparation method according to claim 12, characterized in that: The solid-liquid separation is carried out by combining centrifugation and sieve filtration, wherein the mesh number of the sieve is 100-300 meshes.

16. The preparation method according to claim 12, characterized in that: The drying includes any one of vacuum drying, forced air drying, freeze drying and spray drying.

17. The preparation method according to claim 16, characterized in that: The vacuum drying temperature is 50-80°C.

18. The preparation method according to claim 16, characterized in that: The temperature of blast drying is 60-100°C.

19. The preparation method according to claim 16, characterized in that: The pre-freezing temperature of freeze drying is -40 to -20°C, the sublimation temperature is -20 to 25°C, and the decomposition temperature is 25 to 55°C.

20. The preparation method according to claim 16, characterized in that: The inlet air temperature of spray drying is 120-210℃, and the outlet air temperature is 60-110℃.

21. The preparation method according to claim 12, characterized in that: Before drying, the liquid phase is concentrated.

22. The preparation method according to claim 21, characterized in that: The concentration was carried out by concentration under reduced pressure.

23. The preparation method according to claim 22, characterized in that: The reduced pressure concentration is carried out at 60-80°C and a vacuum degree of -0.07 to -0.10 MPa.

24. The preparation method according to claim 21, characterized in that: The liquid phase is concentrated to a solid content of 10-20%.

25. The preparation method according to claim 12, characterized in that: The method further comprises screening the dried product obtained by drying.

26. The preparation method according to claim 25, characterized in that: The mesh size of the sieve used for sieving is 60-100 meshes.

27. The preparation method according to claim 26, characterized in that: The mesh size of the sieve used for sieving is 80 mesh.

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