An apparatus and method for evaluating fluid distribution in a chromatographic column

Abstract

The application provides an evaluation device and method for fluid distribution of a separation column, which comprises the following steps: loading adsorbents into the separation column, and dividing the separation column into several logical regions according to the height of the separation column from top to bottom, and setting several probes at the boundary of adjacent logical regions; installing a distribution member which can be used to guide and distribute fluid at the top of the separation column; installing a flap which can be used to open and close the liquid outlet at the bottom of the separation column; preparing a liquid containing a tracer component, introducing the liquid containing the tracer component into the separation column from the distribution member, and controlling the liquid flow rate to pass through the logical regions in sequence, collecting the conductivity data of the liquid at the boundary of adjacent logical regions by the probes; discharging the liquid containing the tracer component through the separation member, and then discharging and sampling the adsorbents in different logical regions by controlling the turning of the flap, and measuring the conductivity data of the tracer component in the adsorbents.

Description

Technical Field

[0001] This invention relates to the field of chemical product separation and purification technology, specifically to an apparatus and method for evaluating the fluid distribution in a separation column. Background Technology

[0002] The core component of processes such as simulated moving bed chromatography, chromatographic separation, and ion exchange is the chromatographic separation column, which contains a certain amount of adsorbent and uses a countercurrent flow method to continuously separate liquids in a sequential manner. Therefore, when a liquid passes through a container containing such particles, it can be imagined as a fixed bed, where the fluid distribution is particularly critical. For example, problems such as channeling, turbulence, backmixing, jetting, and retention commonly occur during the separation process. Especially in situations where height and space are limited, only a "pancake" type chromatographic separation column can be designed, and its internal structure inevitably becomes the biggest influencing factor on fluid distribution.

[0003] Currently, process design researchers can only design chromatographic separation column structures based on theoretical knowledge and relevant experience in order to solve the aforementioned problems such as channeling, turbulence, backmixing, jetting, and retention. However, production practice is influenced by many factors, and the problems encountered are often not singular or definite. In such cases, once channeling, turbulence, backmixing, jetting, or retention occurs, the general process for solving these problems is: first, identify where the current structure of the chromatographic separation column cannot match the actual production, and then fill the gaps, or redesign and install the chromatographic separation column. It is very likely that after operation, the effect will still be unsatisfactory. Repeatedly checking for omissions and filling gaps not only seriously affects the project schedule, but also the installation and disassembly process is time-consuming and labor-intensive.

[0004] In summary, developing a method for efficiently and rapidly evaluating the fluid distribution in a separation column has practical guiding significance for processes such as uniform mixing of the liquid to be separated and the mobile phase, and accurate collection of target components during production. Summary of the Invention

[0005] In order to reduce or even eliminate problems such as channeling, short-circuiting, open-circuiting, and dead zones in the fluid of the chromatographic separation column during actual production, and to reduce temperature difference and concentration change, this invention provides an evaluation device and method for the fluid distribution of the separation column.

[0006] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows:

[0007] In a first aspect, the present invention provides a method for evaluating the fluid distribution in a separation column, comprising:

[0008] Step 1: The adsorbent is loaded into the separation column and divided into several logical regions in order from top to bottom according to the height of the separation column. Several probes are set at the interface between adjacent logical regions.

[0009] Step 2: Install a detachable distribution component at the top of the separation column to serve as a drainage and diversion device;

[0010] A flap for opening and closing the liquid outlet of the separation column is installed at the liquid outlet at the bottom of the separation column, and a drive mechanism for controlling the flap to flip to open and close the liquid outlet of the separation column; the flap is provided with a channel for liquid to flow through.

[0011] Step 3: Prepare a liquid containing tracer components, introduce the liquid containing tracer components into the separation column from the distribution component, control the liquid flow rate, and pass it through the logic region in sequence. Collect the conductivity data of the liquid at the interface between adjacent logic regions using probes.

[0012] Step 4: The liquid containing the tracer component is drained through the separation component. Then, the adsorbent in different logic regions is discharged and sampled by controlling the flipping of the flap, and the conductivity data of the tracer component in the adsorbent is measured.

[0013] Furthermore, the distribution component includes a cover plate and an upper inlet disposed on the cover plate, and a distribution plate is provided at the bottom of the cover plate, and the distribution plate is provided with channels for diverting flow; preferably, the bottom surface of the cover plate is a plane, an arc surface, or a conical surface; more preferably, when the bottom surface of the cover plate is a conical surface, a sintered plate with liquid flow holes is disposed below the conical surface.

[0014] Preferably, the distribution plate includes an upper distribution plate and a lower distribution plate, both of which are porous structures; more preferably, the porous structures of the upper distribution plate and the lower distribution plate do not correspond; more preferably, the inner and outer sides are defined with the distance from the center of the separation column as the boundary, the side containing the center of the separation column is the inner side, and the other side of the boundary is the outer side, the opening ratio of the inner side of the upper distribution plate and the lower distribution plate is 1.5-2 times that of the outer side, and the opening ratio of the inner side is preferably 65-85%;

[0015] More preferably, the upper distribution plate radiates outward from the center, and the area within 0.1-0.3 times the radius is a non-perforated area.

[0016] Preferably, a lower outlet for liquid outflow is provided below the flap, and the lower outlet is installed at the bottom of the separation column by a quick-release clamp.

[0017] Preferably, the flap is provided with a central shaft, the central shaft is connected to a drive mechanism, and the drive mechanism is connected to a host computer.

[0018] Preferably, the flap has a three-layer structure, with the pores in the upper and lower layers smaller than those in the middle layer; more preferably, the pore size in the upper and lower layers is 80-100 mesh, and the pore size in the middle layer is 5-10 mesh.

[0019] Preferably, in step 1, the separation column is divided into four logical regions from top to bottom according to its height: logical region I, logical region II, logical region III, and logical region IV; and / or,

[0020] At least three probes are provided on the interface of each adjacent logical region, preferably one of which is located at the center point of the separation column.

[0021] Furthermore, at least one sampling point is provided in each of the logical regions; preferably, two sampling points are provided in each of the logical regions; more preferably, the two sampling points are located on the same plane.

[0022] Secondly, the present invention provides an evaluation device for the fluid distribution of a separation column, including a separation column, wherein the separation column is uniformly divided into several logical regions in a top-to-bottom order, and several probes for detecting conductivity are provided at the interface between adjacent logical regions, wherein the probes are connected to a conductivity meter.

[0023] The top of the separation column is provided with a detachable distribution component that serves to guide and divert the flow;

[0024] The bottom outlet of the separation column is provided with a flap for opening and closing the outlet of the separation column, and a drive mechanism for controlling the flap to flip to open and close the outlet of the separation column; the flap is provided with a channel for liquid to flow through.

[0025] Furthermore, the distribution component includes a cover plate and an upper inlet disposed on the cover plate, a distribution plate is provided at the bottom of the cover plate, and the distribution plate is provided with channels for diverting flow; and / or,

[0026] The flap is provided with a lower outlet for liquid to flow out, and the lower outlet is installed at the bottom of the separation column by a quick-release clamp.

[0027] Preferably, the flap is provided with a central shaft, the central shaft is connected to a drive mechanism, and the drive mechanism is connected to a host computer.

[0028] This invention discloses a device and method for evaluating the fluid distribution of a separation column. It can overcome design flaws in existing core components of simulated moving beds, chromatographic separation, and ion exchange processes in practical applications, as well as problems such as difficulty in replacement and installation, and high maintenance costs. Furthermore, it allows for the evaluation of fluid distribution within the separation column before production use, particularly for effectively assessing the uniform distribution of materials within "pancake" type low aspect ratio separation columns. This enables the selection of the optimal configuration to achieve the best separation, dispersion, and distribution effects, providing significant guidance for large-scale industrial production. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the evaluation device of the present invention.

[0030] Figure 2 This is a probe point diagram of the present invention.

[0031] Figure 3 These are illustrations of different styles of the distribution components of the present invention.

[0032] In the diagram, 1. Distribution component; 2. Upper inlet; 3. Separation column; 4. Probe setting area; 5. Sampling position; 6. Distribution plate; 7. Annular boss; 8. Non-perforated area of ​​the upper distribution plate; 9. Sealing ring; 10. Flip plate; 11. Central shaft; 12. Stepper motor; 13. Quick-release clamp; 14. Cover plate; 15. Lower outlet; 16. Host computer; 17. Probe 1; 18. Probe 2; 19. Probe 3. Detailed Implementation

[0033] In the description of this invention, it should be noted that unless specific conditions are specified in the examples, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0034] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. These descriptions are intended to explain the invention and not to limit it.

[0035] A specific embodiment of the present invention provides a method for evaluating the fluid distribution in a separation column, comprising:

[0036] Step 1: The adsorbent is loaded into the separation column and divided into several logical regions in order from top to bottom according to the height of the separation column. Several probes are set at the interface between adjacent logical regions.

[0037] Step 2: Install a detachable distribution component at the top of the separation column to serve as a drainage and diversion device;

[0038] A flap for opening and closing the liquid outlet of the separation column is installed at the liquid outlet at the bottom of the separation column, and a drive mechanism for controlling the flap to flip to open and close the liquid outlet of the separation column; the flap is provided with a channel for liquid to flow through.

[0039] Step 3: Prepare a liquid containing tracer components, introduce the liquid containing tracer components into the separation column from the distribution component, control the liquid flow rate, and pass it through the logic region in sequence. Collect the conductivity data of the liquid at the interface between adjacent logic regions using probes.

[0040] Step 4: The liquid containing the tracer component is drained through the separation component. Then, the adsorbent in different logic regions is discharged and sampled by controlling the flipping of the flap, and the conductivity data of the tracer component in the adsorbent is measured.

[0041] Furthermore, specific embodiments of the present invention also provide an evaluation device for the fluid distribution in a separation column, such as... Figure 1 As shown, it includes a separation column 3, which is cylindrical in shape and funnel-shaped at the bottom.

[0042] The separation column 3 is evenly divided into several logical regions in a top-to-bottom order. Several probes for detecting conductivity are set at the interface 4 between adjacent logical regions. The probes are connected to a conductivity meter.

[0043] In a preferred embodiment of the present invention, the separation column 3 is divided into four logical regions from top to bottom, namely I, II, III, and IV. At least three probes (17 / 18 / 19) are provided on the interface of each adjacent logical region. Preferably, one probe 17 is located at the center point of the separation column.

[0044] The top of the separation column 3 is provided with a detachable distribution component 1 that serves to guide and divert the flow;

[0045] The bottom outlet of the separation column 3 is provided with a flap 10 for opening and closing the outlet of the separation column, and a stepper motor 12 for controlling the flap 10 to flip to open and close the outlet of the separation column 3; the flap 10 is provided with a channel for liquid to flow through.

[0046] The distribution component 1 includes a cover plate 14 and an upper inlet 2 disposed on the cover plate 14. A distribution plate 6 is provided at the bottom of the cover plate 14, and the distribution plate 6 has channels for diverting flow. A groove is provided at the bottom of the cover plate 14, and a gasket is placed in the groove. An annular boss 7 is inserted into the upper port of the separation column 3. The protrusion of the annular boss 7 matches the groove. When the protrusion of the annular boss 7 is aligned with the groove, the cover plate 14 seals the upper port of the separation column 3.

[0047] Preferably, the bottom surface of the cover plate 14 is a plane, an arc surface of 15 to 35°, or a conical surface of not less than 150°; more preferably, when the bottom surface of the cover plate 14 is a conical surface, a sintered plate with liquid flow holes is provided below the conical surface.

[0048] Preferably, the distribution plate 6 includes an upper distribution plate and a lower distribution plate, both of which are porous structures. Preferably, the porous structures of the upper and lower distribution plates are not corresponding, and there are micro-gaps between them to facilitate liquid flow. More preferably, the inner and outer sides are defined with a point halfway from the center of the separation column as the boundary. The side containing the center of the separation column is the inner side, and the other side of the boundary is the outer side. The opening ratio of the inner side of the upper and lower distribution plates is 1.5-2 times that of the outer side, and the opening ratio of the inner side is preferably 65-85%. Because the liquid flow rate is larger at the center, larger and more numerous holes are needed, while the opposite is true at the edges, ensuring that the linear velocity of all liquid flow cross-sections is consistent after passing through the distribution plate.

[0049] More preferably, the upper distribution plate radiates outward from the center, and the area within 0.1-0.3 times the radius is a non-perforated region 8.

[0050] Below the flap 14 is a lower outlet 15, which is installed at the bottom of the separation column 3 via a quick-release clamp 13. The upper inlet is an inverted cone shape, and the lower outlet is a regular cone shape, the purpose of which is to reduce dead volume. When adsorbent needs to be added, it is opened. Figure 1 The quick-connect clamp 13 releases material by first sinking from the center and then collecting it continuously from top to bottom. The flap 10 has a central shaft 11 connected to a stepper motor 12. The stepper motor 12 drives the central shaft to rotate, thereby rotating the flap 10. The stepper motor 12 is connected to a host computer 16. Preferably, the flap 10 has a three-layer structure (upper, middle, and lower), with the pores in the upper and lower layers smaller than those in the central layer. The pore size in the upper and lower layers is 80-100 mesh, and the pore size in the central layer is 5-10 mesh. Micro-gaps exist between the three layers to facilitate liquid flow.

[0051] In some embodiments of the present invention, the probe 4 may be selected from one or more of the following: thermal conductivity sensor, electrical conductivity sensor, pH sensor, humidity sensor, density sensor, concentration sensor, and moisture sensor. However, it is not limited to these types.

[0052] In a preferred embodiment of the present invention, in step 1, the separation column is divided into four logical regions in order from top to bottom according to its height: logical region I, logical region II, logical region III, and logical region IV; at least three probes are provided on the interface of each adjacent logical region, one of which is located at the center point of the separation column.

[0053] More preferably, at least one sampling point 5 is set in each of the logical regions; preferably, two sampling points are set in each of the logical regions; more preferably, the two sampling points are located on the same plane. The adsorbent material descends from the center, and the adsorbent at the corresponding sampling point can be collected according to the weight and the height of the logical region. Then, XRF analysis is performed to calculate its exchange rate, which is compared with the liquid conductivity detected by the probe.

[0054] Example 1

[0055] use Figure 3 The distribution structure of sample group 1 involves filling the separation column with approximately 2.5-3.5 kg of NaY-type adsorbent, followed by the installation of the cover plate, distribution plate, and separator. The lower outlet is then fixed, and a constant flow pump is used to pump the adsorbent containing 0.2-0.5 mol / L Li at a flow rate of 1.0-1.5 times the bed density. + The solution is injected through the top inlet.

[0056] Conductivity sensors (probes) are installed at the interfaces of logical partitions I, II, III, and IV. Specifically, probes are placed at the center of the interface, at the 1 / 2 mark between the center and the inner wall of the separation column, and at the 1 / 4 mark. That is, probes I-T1, I-T2, and I-T3 are placed at the cross-sections of region I and region II; probes II-T1, II-T2, and II-T3 are placed at the cross-sections of region II and region III; and probes III-T1, III-T2, and III-T3 are placed at the cross-sections of region III and region IV. Figure 2 As shown, the conductivity values ​​obtained by the corresponding probes are recorded.

[0057] Furthermore, within the plane at half the height of each region, two sampling points were randomly set at the midpoint between the center and the inner wall of the separation column: location I-W1 and location I-W2 in region I, location II-W1 and location II-W2 in region II, location III-W1 and location III-W2 in region III, and location IV-W1 and location IV-W2 in region IV. The effectiveness of the distribution structure was determined by comparing the similarity of the conductivity values ​​of each probe and site.

[0058] After collecting probe data, Li + The solution is replaced with softened water at a flow rate of 2.5-3 times the bed density to displace free ions. Dry nitrogen is used to clean the adsorbent, surface, and internal solution in the separation column. The lower outlet is removed, and the host computer sends commands to the stepper motor at 5-10 minute intervals to control the flip plate to collect the adsorbent in each sampling site area for conductivity testing.

[0059] Calculate its commutativity using the following formula.

[0060] The degree of exchange α = W1 / W2 × 100%; where W1 is the sodium ions exchanged; and W2 is the sodium ions before exchange.

[0061] Basic principle: This embodiment uses a conductivity sensor as a probe, containing Li + The solution and the Na in the NaY solid particles in the separation column + An exchange occurs, initially involving a small amount of Na. + With Li + As the conductivity increases, the electrical conductivity also increases.

[0062] In style group 1:

[0063] 1-1 The contact surface between the interior of the distribution component and the distribution plate is flat, with no blind plate.

[0064] The contact surface between the interior of the 1-2 distribution component and the distribution plate is a plane, radiating outward from the center, and the area within 0.18 times the radius is the blind plate area.

[0065] The contact surface between the interior of the 1-3 distribution component and the distribution plate is planar, without a blind plate. The upper inlet is inserted into the distribution component at 2 / 3 of its length, with the remainder being an internal channel passing through the interior of the distribution component. Table 1 shows the conductivity data of the sampling points in region I and the cross-sectional probes in regions I and II.

[0066] Table 1. Numerical results of probe and sampling sites in Example 1

[0067]

[0068] In Example 1, the conductivity data monitored by the three probe patterns differed significantly. Among the exchange rate data detected at each point, the differences between patterns 1-2 were relatively small, while the differences between the other groups were large. Therefore, this distribution component is not suitable for 0.2-0.5 mol / L Li + Separation and purification of solution systems.

[0069] Example 2

[0070] Adopting attachment Figure 3 The distribution structure of pattern group 2 is the same as that in embodiment 1. Table 2 shows the conductivity data of probes II-T1, II-T2, and II-T3 in regions II and III, as well as sites II-W1 and II-W2 in region II.

[0071] In style group 2:

[0072] 2-1 The contact surface between the interior of the distribution component and the distribution plate is a 25° arc surface, with no blind plate.

[0073] 2-2 The contact surface between the interior of the distribution component and the distribution plate is an arc surface, radiating outward from the center, and the blind plate area is within 0.22 times the radius.

[0074] 2-3 The contact surface between the inside of the distribution component and the distribution plate is an arc surface, radiating outward from the center. The blind plate area is within 0.22 times the radius. The upper inlet is inserted into the distribution component at 2 / 3 of its length, and the remainder is an inner channel passing through the inside of the distribution component.

[0075] Table 2. Numerical results of probe and sampling sites in Example 2

[0076]

[0077] In Example 2, the conductivity data monitored by the three probe patterns were all less different than those in Example 1, while the exchange rate data detected at each point differed significantly. Therefore, this distribution component is also not suitable for 0.2-0.5 mol / L Li. + Separation and purification of solution systems.

[0078] Example 3

[0079] Adopting attachment Figure 3 The distribution structure of pattern group 3 is the same as that in embodiment 1. Table 3 gives the conductivity data of probes III-T1, III-T2, and III-T3 in regions III and IV, as well as sites III-W1 and III-W2 in region III.

[0080] In style group 3:

[0081] 3-1 The contact surface between the interior of the distribution component and the distribution plate is a 150° conical surface, without a blind plate.

[0082] 3-2 The contact surface between the interior of the distribution component and the distribution plate is an inclined surface, radiating outward from the center, and the blind plate area is within 0.21 times the radius.

[0083] 3-3 The contact surface between the distribution component and the distribution plate is an inclined surface, radiating outward from the center. The blind plate area is within 0.21 times the radius. The upper inlet is inserted into the distribution component at 2 / 3 of its length, and the remainder is an inner channel passing through the interior of the distribution component.

[0084]

[0085]

[0086] Table 3. Numerical results of probe and sampling sites in Example 5.

[0087] In Example 3, the conductivity data monitored by the three probe types were all less different than those in Example 1, but the exchange rate data detected at each point still differed significantly. Therefore, this distribution component is not suitable for 0.2-0.5 mol / L Li. + Separation and purification of solution systems.

[0088] Example 4

[0089] Adopting attachment Figure 3 The distribution structure of pattern group 4 is the same as in embodiment 1. Table 4 gives the conductivity data of probes III-T1, III-T2, and III-T3 in regions III and IV, as well as sites IV-W1 and IV-W2 in region IV.

[0090] In style group 4:

[0091] 4-1 The contact surface between the inside of the distribution component and the distribution plate is a 150° conical surface, with an 80-mesh sintered plate added between them, and no blind plate.

[0092] 4-2 The contact surface between the interior of the distribution component and the distribution plate is a 150° conical surface, with an 80-mesh sintered plate added between them. The blind plate area is within 0.25 times the radius of the center radiating outward.

[0093] 4-3 The contact surface between the inside of the distribution component and the distribution plate is a 150° conical surface, with an 80-mesh sintered plate added between them. The area radiates outward from the center, and the blind plate area is within 0.25 times the radius. The upper inlet is inserted into the distribution component at 2 / 3 of its length, and the remainder is an inner channel passing through the inside of the distribution component.

[0094] Table 4. Numerical results of probe and sampling sites in Example 6.

[0095]

[0096] In Example 4, the conductivity data monitored by the three probe patterns were all relatively similar, and the exchange rate data detected at each point were also relatively similar. Pattern 4-2 was the most prominent among the three groups. Therefore, these three groups of distribution components are suitable for 0.2-0.5 mol / L Li + Separation and purification of solution systems, especially Pattern 4-2.

[0097] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A method for evaluating the fluid distribution in a separation column, characterized in that: An evaluation device for fluid distribution in a separation column is used. The evaluation device includes a separation column, which is uniformly divided into several logical regions in a top-to-bottom order. Several probes for detecting conductivity are set at the interface between adjacent logical regions, and the probes are connected to a conductivity meter. The top of the separation column is provided with a detachable distribution component that serves to guide and divert the flow; the distribution component includes a cover plate and an upper inlet provided on the cover plate, the bottom of the cover plate is provided with a distribution plate, and the distribution plate is provided with channels for diverting the flow; The bottom outlet of the separation column is provided with a flap for opening and closing the outlet of the separation column, and a drive mechanism for controlling the flap to flip to open and close the outlet of the separation column; the flap is provided with a channel for liquid to flow through. The evaluation method includes: Step 1: Load the adsorbent into the separation column; Step 2: Prepare a liquid containing tracer components, introduce the liquid containing tracer components into the separation column from the distribution component, control the liquid flow rate, and pass it through the logic region in sequence. Collect the conductivity data of the liquid at the interface between adjacent logic regions using a probe. Step 3: The liquid containing the tracer component is drained through the separation component. Then, the adsorbent in different logic regions is discharged and sampled by controlling the flipping of the flap, and the conductivity data of the tracer component in the adsorbent is measured.

2. The method for evaluating the fluid distribution in a separation column according to claim 1, characterized in that: The bottom surface of the cover plate can be a plane, an arc, or a cone.

3. The method for evaluating the fluid distribution in a separation column according to claim 2, characterized in that: When the bottom surface of the cover plate is a conical surface, a sintered plate with liquid flow holes is provided below the conical surface.

4. The method for evaluating the fluid distribution in a separation column according to claim 1, characterized in that: The distribution plate includes an upper distribution plate and a lower distribution plate, both of which are porous structures.

5. The method for evaluating the fluid distribution in a separation column according to claim 4, characterized in that: The porous structures of the upper distribution plate and the lower distribution plate do not correspond.

6. The method for evaluating the fluid distribution in a separation column according to claim 5, characterized in that: The inner and outer sides are defined with the distance from the center of the separation column at 1 / 2 as the boundary. The side containing the center of the separation column is the inner side, and the other side of the boundary is the outer side. The opening ratio of the inner side of the upper distribution plate and the lower distribution plate is 1.5-2 times that of the outer side.

7. The method for evaluating the fluid distribution in a separation column according to claim 6, characterized in that: The inner opening ratio of the upper distribution plate and the lower distribution plate is 65-85%.

8. The method for evaluating the fluid distribution in a separation column according to claim 6 or 7, characterized in that: The upper distribution plate radiates outward from the center, and the area within 0.1-0.3 times the radius is a non-perforated area.

9. The method for evaluating the fluid distribution in a separation column according to claim 1, characterized in that: The flap is provided with a lower outlet for liquid to flow out, and the lower outlet is installed at the bottom of the separation column by a quick-release clamp.

10. The method for evaluating the fluid distribution in a separation column according to claim 9, characterized in that: The flap is provided with a central shaft, which is connected to a drive mechanism, and the drive mechanism is connected to a host computer.

11. The method for evaluating the fluid distribution in a separation column according to claim 9 or 10, characterized in that: The flap has a three-layer structure, with the pores in the upper and lower layers being smaller than those in the middle layer.

12. The method for evaluating the fluid distribution in a separation column according to claim 11, characterized in that: The pore size of the upper and lower layers is 80-100 mesh, and the pore size of the middle layer is 5-10 mesh.

13. The method for evaluating the fluid distribution in a separation column according to claim 1, characterized in that: In step 1, based on the height of the separation column, it is divided into four logical regions in descending order: logical region I, logical region II, logical region III, and logical region IV; and / or, At least three probes are set on the interface of each adjacent logical region.

14. The method for evaluating the fluid distribution in a separation column according to claim 13, characterized in that: The system shall have at least three probes, one of which shall be located at the center of the separation column.

15. The method for evaluating the fluid distribution in a separation column according to claim 13 or 14, characterized in that: At least one sampling point is set in each of the logical regions.

16. The method for evaluating the fluid distribution in a separation column according to claim 15, characterized in that: Two sampling points are set in each of the logical regions.

17. The method for evaluating the fluid distribution in a separation column as described in claim 16, characterized in that: The two sampling points are located on the same plane.

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