A composition with whitening efficacy and a preparation method and application thereof

Abstract

The present application relates to a composition with whitening effect and its preparation method and application, the composition with whitening effect includes: ascorbic acid polypeptide, dimethyl methoxy benzodioxole, fibronectin, sea beet extract and methoxy cinnamic acid ethyl hexyl ester. The application creatively finds that the composition of ascorbic acid polypeptide, dimethyl methoxy benzodioxole, fibronectin, sea beet extract and methoxy cinnamic acid ethyl hexyl ester can effectively inhibit the multiple pathways of melanin production, so as to achieve the effect of more excellent skin whitening, and the five components have certain synergistic effect on the above effect, and are very suitable for whitening cosmetics, mild and non-irritating.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition with whitening effect, its preparation method and application, and particularly to a composition with whitening effect and an essence with whitening effect and its preparation method. Background Technology

[0002] "Skin whitening" has always been a constant theme in the beauty market, with consistently huge market demand. Whitening, fading spots, removing blemishes, brightening, and reducing dark spots are the main demands for skin whitening functions. The depth of skin color is regulated by multiple factors, primarily depending on the content and distribution of melanin. Melanin is an amino acid derivative, formed from tyrosine or 3,4-dihydroxyphenylalanine through a series of chemical reactions, and it often exists in a polymerized form. Melanin is synthesized by melanocytes in the basal layer of the human epidermis. When ultraviolet rays irradiate the skin, the skin enters a "self-protective" state, activating tyrosinase to catalyze the oxidation of tyrosine or 3,4-dihydroxyphenylalanine to produce melanin to protect skin cells. Melanin then moves through layers of cell metabolism, eventually reaching the epidermis to form freckles, sunspots, and dark spots.

[0003] Melanin formation is a highly complex process. Therefore, to achieve effective whitening, it's necessary to comprehensively inhibit melanin production and its migration to the stratum corneum. However, some whitening products on the market only target one aspect of melanin formation, making it difficult to achieve a truly comprehensive and effective result. Furthermore, since most whitening ingredients are active molecules, their stability is poor, and they are easily oxidized and discolored, thus losing their effectiveness. For example, commonly used vitamin C (ascorbic acid) is easily oxidized and deactivated, causing the product to darken and creating an unpleasant sensory experience for consumers. Other commonly used whitening agents, such as 4-butylresorcinol and kojic acid, not only easily discolor but also irritate the skin. People with sensitive or fragile skin may not tolerate them, and long-term use of irritating ingredients can lead to inflammation, which can exacerbate melanin production, thus preventing products containing these whitening ingredients from achieving their intended effects.

[0004] CN114796046A discloses a whitening, spot-fading, and antioxidant composition and its application. The composition comprises N-acetylneuraminic acid, tranexamic acid, hop extract, and lotus germ extract. This invention creatively combines these four active ingredients for whitening, spot-fading, and antioxidant effects; the four components complement each other and have a synergistic effect.

[0005] CN113648270A discloses a whitening and moisturizing essence lotion and its preparation method, comprising the following raw materials in parts by weight: water 2-5 parts, glycerin 3-6 parts, cucumber juice 5-8 parts, fragrance 4-6 parts, carbomer 2-5 parts, mink oil 5-8 parts, petrolatum 2-4 parts, triethanolamine 4-6 parts, glyceryl stearate 2-5 parts, antioxidant 4-6 parts, anti-inflammatory light makeup water 4-6 parts, honey water 4-6 parts, herbal extract of senna 8-10 parts, vitamins 4-6 parts, ginseng extract 8-10 parts, and deer antler extract 1-3 parts. This invention has strong moisturizing ability, but there is no specific data to prove its whitening effect.

[0006] The whitening effects of existing products are not very significant or long-lasting. Therefore, it is very meaningful to develop a product with a simple preparation method, significant whitening effect, and long-lasting effect. Summary of the Invention

[0007] In view of the shortcomings of the prior art, the purpose of this invention is to provide a composition with whitening effect, its preparation method and application, specifically a composition with whitening effect and an essence with whitening effect and its preparation method.

[0008] To achieve this objective, the present invention adopts the following technical solution:

[0009] In a first aspect, the present invention provides a composition having whitening effect, the composition comprising: ascorbic acid polypeptide, dimethylmethoxybenzodihydropyranol, fibronectin, lepidocrocite extract and ethylhexyl methoxycinnamate.

[0010] Ascorbic acid peptides are natural, stable, and non-discoloring ascorbic acid derivatives containing multiple short peptides. Through the action of α-peptidase and α-peptidase in the skin, the ascorbic acid contained in the ascorbic acid peptides is gradually released, thus exerting its anti-ascorbic effect. Ascorbic acid has multiple benefits, including inhibiting melanin synthesis by melanocytes, reducing existing melanin, lightening skin pigmentation, scavenging free radicals, promoting collagen synthesis, inhibiting bacteria, reducing lipid peroxidation, and reducing inflammatory damage. This invention, by adding this ingredient, combines the benefits of natural vitamin C with the advantage of stability and non-discoloration.

[0011] Dimethylmethoxybenzodihydropyranol has a strong inhibitory effect on tyrosinase, which is better than that of kojic acid and arbutin; it protects the skin from UV damage, has excellent stability, does not discolor, is non-toxic to skin cells, and has excellent safety.

[0012] Fibronectin is widely found in tissues and tissue fluid. It is a high-molecular-weight glycoprotein that plays an important role in promoting cell adhesion, migration, growth, proliferation and differentiation. It can promote the synthesis of hyaluronic acid and ceramide, and can also mobilize phagocytes to clear abnormally accumulated melanin in the skin and reduce melanin secretion, thus having the effects of removing spots and whitening the skin.

[0013] The extract of *Gynostemma pentaphyllum* contains a variety of bioactive components, such as alkaloids, terpenes, flavonoids, and glucosinolates. It can reduce melanin production by inhibiting the expression of MITF and also has anti-inflammatory and antibacterial effects.

[0014] Ethylhexyl methoxycinnamate is an oil-soluble UVB sunscreen with an absorption wavelength between 290-320 nm. It can also act as a penetration enhancer to promote the absorption of active ingredients. In the composition of this invention, this component can serve as an excellent solvent for dimethylmethoxybenzodihydropyranol, allowing it to dissolve better into the product and ensuring its stability and non-precipitation within the product.

[0015] This invention creatively combines the above five active ingredients for whitening. The five active ingredients complement each other and have a synergistic effect. Each ingredient inhibits the production or transfer of melanin from all angles through different pathways or mechanisms, making the whitening effect of the product significant and long-lasting.

[0016] Preferably, the whitening composition comprises, by weight parts: 0.5-5 parts ascorbic acid polypeptide, 0.1-2 parts dimethylmethoxybenzodihydropyranol, 1-5 parts fibronectin, 0.5-5 parts *Gynostemma pentaphyllum* extract, and 0.3-6 parts ethylhexyl methoxycinnamate.

[0017] The amount of the ascorbic acid polypeptide can be 0.5 parts, 0.6 parts, 0.8 parts, 1.0 parts, 2.0 parts, 3.0 parts, 4.0 parts, 5.0 parts, etc.

[0018] The amount of dimethylmethoxybenzodihydropyranol can be 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1.0 parts, 1.2 parts, 1.5 parts, 2.0 parts, etc.

[0019] The amount of fibronectin can be 1.0 part, 1.2 parts, 2.0 parts, 3.0 parts, 4.0 parts, 5.0 parts, etc.

[0020] The amount of the extract can be 0.5 parts, 1.0 parts, 1.5 parts, 2.0 parts, 3.0 parts, 4.0 parts, 5.0 parts, etc.

[0021] The amount of ethylhexyl methoxycinnamate can be 0.3 parts, 0.5 parts, 1.0 parts, 1.5 parts, 2.0 parts, 3.0 parts, 4.0 parts, 5.0 parts, 6.0 parts, etc.

[0022] Other specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0023] In a second aspect, the present invention provides the application of the whitening composition described in the first aspect in the preparation of cosmetics, the cosmetics including serums, essential oils, lotions, creams, masks, eye creams, or facial cleansers.

[0024] Thirdly, the present invention provides a whitening essence, the essence comprising: the whitening composition described in the first aspect, a skin conditioning agent, an emulsifier, a thickener, a moisturizer, and water.

[0025] Preferably, the whitening essence contains, by mass fraction, 2-25% of the whitening composition described in the first aspect, 0.1-10% of a skin conditioning agent, 1-10% of an emulsifier, 10-20% of a thickener, 35-60% of a moisturizer, and water.

[0026] The composition having whitening effect can have a mass fraction of 2%, 3%, 5%, 10%, 15%, 20%, 25%, etc.

[0027] The mass fraction of the skin conditioning agent can be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 2.0%, 4.0%, 5.0%, 8.0%, 10.0%, etc.

[0028] The mass fraction of the emulsifier can be 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.

[0029] The mass fraction of the thickener can be 10%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, etc.

[0030] The mass fraction of the humectant can be 35%, 42%, 43%, 44%, 45%, 47%, 49%, 50%, 53%, 55%, 60%, etc.

[0031] Other specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0032] Preferably, the skin conditioning agent comprises any one or a combination of at least two of the following: tranexamic acid, nicotinamide, glycyrrhizin, resveratrol, carnosine, 4-butylresorcinol, allantoin, osmanthus cell water, or *Saussurea involucrata* extract; more preferably, the skin conditioning agent is a combination of osmanthus cell water and allantoin.

[0033] Osmanthus cell water is a natural plant extract obtained through a low-temperature microwave extraction process using fresh osmanthus flowers. It is a mild substance with excellent oil-controlling, toning, antioxidant, skin-brightening, and anti-aging effects. Allantoin, when used in combination with osmanthus cell water as a skin conditioning agent, synergistically enhances the whitening effect of the composition in this invention, further promoting whitening and improving skin condition.

[0034] Fourthly, the present invention provides a method for preparing the whitening serum described in the third aspect, the method comprising the following steps:

[0035] (1) Mix and heat dimethylmethoxybenzodihydropyranol, ethylhexyl methoxycinnamate and emulsifier, add some humectant to obtain the first mixture; weigh water, thickener, chelating agent and some humectant, stir and heat, homogenize to completely dissolve the solid to obtain the second mixture;

[0036] (2) Mix the first mixture and the second mixture obtained in step (1), homogenize and emulsify, and then cool down; add pH adjuster, remaining moisturizer, ascorbic acid peptide, fibronectin, angelica extract and skin conditioner, mix and homogenize evenly to obtain the whitening essence.

[0037] Preferably, the heating temperature in step (1) is independently 75-90°C, such as 75°C, 77°C, 79°C, 80°C, 85°C, 88°C, 90°C, etc.

[0038] Preferably, the temperature to which the temperature is cooled in step (2) is 40-50℃, such as 40℃, 42℃, 43℃, 45℃, 46℃, 48℃, 50℃, etc.

[0039] Preferably, the homogenization emulsification time in step (2) is 5-10 minutes, such as 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, etc., and more preferably, it is 8-10 minutes.

[0040] Other specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0041] Compared with the prior art, the present invention has the following beneficial effects:

[0042] This invention creatively provides a skin-whitening composition comprising ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, and ethylhexyl methoxycinnamate. This composition effectively inhibits multiple pathways of melanin production, thereby achieving superior skin-whitening effects. The combination of this composition with a skin conditioning agent exhibits a synergistic effect, significantly enhancing the composition's ability to inhibit melanocyte activity and reduce melanin content. Detailed Implementation

[0043] To further illustrate the technical means and effects of the present invention, the following description, in conjunction with preferred embodiments, further explains the technical solution of the present invention. However, the present invention is not limited to the scope of these embodiments. The sources of some components in the embodiments and comparative examples are as follows:

[0044] The weight parts of ascorbic acid peptide, dimethyl methoxybenzodihydropyranol, fibronectin, lepidocrocum extract, and ethylhexyl methoxycinnamate mentioned below are based on the actual content of the active ingredients contained in commercially available raw materials. Commercially available raw materials may also selectively contain any one or a combination of at least two of the following: solvents, fillers, diluents, stabilizers, pH adjusters, antibacterial agents, antioxidants, or impurities within permissible limits.

[0045] The ascorbic acid peptides involved in the following examples, comparative examples, application examples, and comparative application examples were derived from the VC peptide product purchased from Tianjin Hongshunke Biotechnology Co., Ltd.; the fibronectin involved were derived from the fibronectin product purchased from Tianjin Hongshunke Biotechnology Co., Ltd.; the *Ligusticum striatum* extract involved were derived from the *Ligusticum striatum* extract product purchased from Fanlin Chemical Technology (Guangzhou) Co., Ltd.; the lecithin involved were derived from the 62962 lecithin product purchased from Merck Chemical Technology (Shanghai) Co., Ltd.; the osmanthus cell water involved were derived from the product purchased from Sichuan Xiangzhiyuan Biotechnology Co., Ltd.; the glycyrrhizin involved were derived from the glycyrrhizin C product purchased from Gansu Fanzhi Pharmaceutical Co., Ltd.; and the resveratrol involved were derived from the resveratrol product purchased from Tianjin Hongshunke Biotechnology Co., Ltd.

[0046] Example 1

[0047] This embodiment provides a composition with whitening effects, which comprises the following active ingredients in parts by weight: 5 parts ascorbic acid peptide, 2 parts dimethylmethoxybenzodihydropyranol, 5 parts fibronectin, 5 parts *Gynostemma pentaphyllum* extract, and 6 parts ethylhexyl methoxycinnamate. The preparation method involves uniformly mixing the commercially available raw materials.

[0048] Example 2

[0049] This embodiment provides a composition with whitening effects, which comprises the following active ingredients by weight: 2.5 parts ascorbic acid peptide, 1 part dimethylmethoxybenzodihydropyranol, 3 parts fibronectin, 2.5 parts *Gynostemma pentaphyllum* extract, and 3 parts ethylhexyl methoxycinnamate. The preparation method involves uniformly mixing all commercially available raw materials.

[0050] Example 3

[0051] This embodiment provides a composition with whitening effects, which comprises the following active ingredients by weight: 0.5 parts ascorbic acid peptide, 0.1 parts dimethylmethoxybenzodihydropyranol, 1 part fibronectin, 0.5 parts *Gynostemma pentaphyllum* extract, and 0.3 parts ethylhexyl methoxycinnamate. The preparation method involves uniformly mixing the commercially available raw materials.

[0052] Application Example 1

[0053] This application example provides a whitening serum with the following formula:

[0054]

[0055] Its preparation method is as follows:

[0056] (1) Add phase A to the emulsification pot, stir and heat to 85°C until the solid is completely dissolved, then add phase B and stir well before use.

[0057] (2) Stir and heat phase C to 85°C, homogenize to completely dissolve the solid, then add the mixture obtained in step (1), homogenize and emulsify for 10 minutes, and then cool down. When the temperature drops to 45°C, add phases D, E, and F and homogenize to obtain the essence.

[0058] Application Example 2

[0059] This application example provides a whitening serum. The formula differs from Application Example 1 only in that the ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, and ethylhexyl methoxycinnamate maintain the weight ratio of Example 2, and the total amount of the five ingredients remains unchanged. The preparation method is the same as in Application Example 1.

[0060] Application Example 3

[0061] This application example provides a whitening serum. The formula differs from Application Example 1 only in that the ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, and ethylhexyl methoxycinnamate maintain the weight ratio of Example 3, and the total amount of the five ingredients remains unchanged. The preparation method is the same as in Application Example 1.

[0062] Comparative Application Example 1

[0063] This comparative application example provides a whitening serum. The formula differs from Application Example 1 in that it does not contain ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, or ethylhexyl methoxycinnamate. It also includes glycyrrhizin at a concentration of 0.5%, while all other ingredients and their concentrations remain unchanged. The preparation method is the same as in Application Example 1.

[0064] Comparative Application Example 2

[0065] This comparative application example provides a whitening serum. The formula differs from Application Example 1 in that it does not contain ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, or ethylhexyl methoxycinnamate. It also includes resveratrol at a concentration of 1%, while all other ingredients and their concentrations remain unchanged. The preparation method is the same as in Application Example 1.

[0066] Comparative Application Example 3

[0067] This comparative application example provides a whitening serum. The only difference between this serum and Application Example 1 is that it does not contain ascorbic acid peptides. The reduced mass of these peptides is proportionally allocated to the content of dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, and ethylhexyl methoxycinnamate. All other ingredients and their contents remain unchanged. The preparation method is the same as in Application Example 1.

[0068] Comparative Application Example 4

[0069] This comparative application example provides a whitening serum, the only difference between its formula and Application Example 1 is that it does not contain dimethylmethoxybenzodihydropyranol. The reduced mass is proportionally allocated to the content of ascorbic acid peptides, fibronectin, *Lepidium apetalum* extract, and ethylhexyl methoxycinnamate, while the other raw materials and their contents remain unchanged. Its preparation method is the same as in Application Example 1.

[0070] Comparative Application Example 5

[0071] This comparative application example provides a whitening serum, the only difference between its formula and Application Example 1 is that it does not contain ethylhexyl methoxycinnamate. The reduced mass is proportionally allocated to the content of ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, and *Ligustrum lucidum* extract, while the other ingredients and their contents remain unchanged. Its preparation method is the same as in Application Example 1.

[0072] Comparative Application Example 6

[0073] This comparative application example provides a whitening serum, the only difference between its formula and Application Example 1 is that it does not contain fibronectin. The reduced mass is proportionally allocated to the content of ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, *Ligustrum lucidum* extract, and ethylhexyl methoxycinnamate, while the other raw materials and their contents remain unchanged. Its preparation method is the same as in Application Example 1.

[0074] Comparative Application Example 7

[0075] This comparative application example provides a whitening serum, the only difference between its formula and Application Example 1 is that it does not contain *Gynostemma pentaphyllum* extract. The reduced mass of *Gynostemma pentaphyllum* extract is proportionally allocated to the content of ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, and ethylhexyl methoxycinnamate. All other ingredients and their contents remain unchanged. Its preparation method is the same as in Application Example 1.

[0076] Comparative Application Example 8

[0077] This comparative application example provides a commercially available whitening serum.

[0078] Application Example 4

[0079] This application example provides a whitening serum, the formula of which differs from Application Example 1 in that the skin conditioning agent contains only 0.1% allantoin and does not contain osmanthus water; the reduced mass is proportionally reduced into water. Its preparation method is the same as in Application Example 1.

[0080] Application Example 5

[0081] This application example provides a whitening serum. The formula differs from Application Example 1 in that the skin conditioning agent contains only 10.1% osmanthus cell water and does not contain allantoin; all other ingredients and their contents remain unchanged. The preparation method is the same as in Application Example 1.

[0082] Comparative Application Example 9

[0083] This comparative application example provides a whitening serum, the difference in formula from Application Example 1 being that it does not contain allantoin or osmanthus cell water, and the reduced mass is proportionally reduced into water. Its preparation method is the same as in Application Example 1.

[0084] Test Example 1

[0085] Skin safety test:

[0086] The whitening essence products with efficacy prepared in Application Examples 1-5 and Comparative Application Examples 1-9 were placed in a patch applicator. The patch applicator containing the test substance was applied to the flexor side of the forearm of 30 subjects. The patch was then gently pressed with the palm of the hand to ensure even application to the skin for 24 hours. Skin irritation and sensitization were observed according to Table 1 (Skin reaction grading standard for closed patch test) at 30 min, 24 h, and 48 h after the patch applicator was removed, and the observation results were recorded.

[0087] Table 1

[0088]

[0089]

[0090] The results showed that no adverse skin reactions occurred in the products of Application Examples 1-5 and Comparative Application Examples 1-9, indicating that the eye repair composition and eye mask involved in the present invention are safe and non-irritating to the skin.

[0091] Test Example 2

[0092] Skin melanin and heme content test:

[0093] 1. Experimental instruments: Mexameter MX18 (melanin and heme tester), one thermometer and hygrometer.

[0094] 2. Testing Principle: Skin color is primarily determined by two pigments. The test is based on the principle of light absorption. The test probe emits three specific wavelengths of light, and the receiver receives the light reflected from the skin. The positions of the emitter and receiver in the probe ensure that only diffused and scattered light can be measured. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be determined by measuring the amount of reflected light. Melanin is tested using two wavelengths of light; these two wavelengths are chosen to obtain the different absorption rates of melanin. For heme testing, two wavelengths of light are chosen to determine the skin's absorption capacity. One of these wavelengths corresponds to the absorption peak of heme, while the other wavelength is used to avoid the influence of other colors such as bilirubin.

[0095] 3. Test subjects: 20 people in each group, 14 groups in total, volunteers aged 18-50 years old, with an average age of 35 years old, healthy skin, and no history of skin diseases or allergies.

[0096] 4. Test conditions: At room temperature of 20±2℃ and relative humidity of 50±5%, after the subjects used the same amount of the above application example and the control application example of the essence, they were left to stand for 30 minutes before the relevant data were tested.

[0097] 5. Experimental Procedure: In this experiment, the subjects were divided into 14 groups. Each group applied an equal amount of the essence from Application Examples 1-5 and Comparative Application Examples 1-9 of this invention topically. The subjects applied the essence to their faces twice a day, morning and evening, for 4 weeks. The melanin (MI) and hemoglobin (EI) values ​​of the skin at the test sites were measured using a Mexameter MX18 (melanin and hemoglobin analyzer).

[0098] (1) Skin melanin content MI value

[0099] In this test, the MI measured by the subject in week 0 was set as M. I0 In the fourth week, MI was set to MI4, and the change value of MI was △MI. △MI = MI4 - MI0, and the change rate of △MI = (MI4 - MI0) / MI0 × 100%. The change rate of △MI was negative, and the lower the value, the less melanin content in the skin after four weeks of product use, which means that the product has a better effect on lightening pigmentation and whitening. The results are shown in Table 2.

[0100] Table 2

[0101]

[0102]

[0103] (2) Skin hemoglobin content EI value

[0104] In this test, the EI measured by the subjects in week 0 was set as EI0, ​​and the EI in week 4 was set as EI4. The change in EI was ΔEI, where ΔEI = EI4 - EI0, ​​and the rate of change of ΔEI = (EI4 - EI0) / EI0 × 100%. The rate of change of ΔEI was negative, and the lower the value, the less hemoglobin content in the skin after four weeks of product use, meaning the skin would be whiter, have a better complexion, and the product would have a better whitening and brightening effect. The average rate of change of ΔEI for each group of 20 people after 4 weeks of use compared with the initial value is shown in Table 3.

[0105] Table 3

[0106]

[0107]

[0108] As shown in Tables 2 and 3, the whitening composition and essence involved in this invention possess excellent whitening effects. Furthermore, ascorbic acid peptides, dimethylmethoxybenzodihydropyranol, fibronectin, *Ligustrum lucidum* extract, and ethylhexyl methoxycinnamate have a synergistic effect in enhancing the whitening effect. The addition of skin conditioning agents further promotes the whitening effect. Simultaneously, the combination of allantoin and / or osmanthus cell water also affects the whitening effect. When allantoin and osmanthus cell water are used simultaneously in a specific ratio, they synergistically enhance the effects of the whitening composition in this invention, further promoting the whitening effect, improving skin condition, and maximizing the whitening effect.

[0109] The applicant declares that the detailed process equipment and process flow of this invention are illustrated through the above embodiments, but this invention is not limited to the above detailed process equipment and process flow, that is, it does not mean that this invention must rely on the above detailed process equipment and process flow to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of raw materials for the products of this invention, additions of auxiliary components, and selection of specific methods, all fall within the protection scope and disclosure scope of this invention.

Claims

1. A composition having whitening effects, characterized in that, The whitening composition comprises ascorbic acid peptide, dimethylmethoxybenzodihydropyranol, fibronectin, angelica extract, and ethylhexyl methoxycinnamate.

2. The composition with whitening effect according to claim 1, characterized in that, The whitening composition comprises, by weight, 0.5-5 parts of ascorbic acid polypeptide, 0.1-2 parts of dimethylmethoxybenzodihydropyranol, 1-5 parts of fibronectin, 0.5-5 parts of *Gynostemma pentaphyllum* extract, and 0.3-6 parts of ethylhexyl methoxycinnamate.

3. The use of the composition with whitening effect according to claim 1 or 2 in the preparation of whitening cosmetics.

4. The application according to claim 3, characterized in that, The whitening cosmetics include serums, essential oils, lotions, face creams, face masks, eye creams, or facial cleansers.

5. A whitening serum, characterized in that, The essence comprises: the whitening composition as described in claim 1 or 2, a skin conditioning agent, an emulsifier, a thickener, a moisturizer, and water.

6. The whitening essence according to claim 5, characterized in that, The essence comprises, by mass fraction: 2-25% of the whitening composition as described in claim 1 or 2, 0.1-10% of a skin conditioning agent, 1-10% of an emulsifier, 10-20% of a thickener, 35-60% of a moisturizer, and water.

7. The whitening essence according to claim 5, characterized in that, The skin conditioning agent includes any one or a combination of at least two of the following: tranexamic acid, niacinamide, glycyrrhizin, resveratrol, carnosine, 4-butylresorcinol, allantoin, osmanthus cell water, or Saussurea costatum extract.

8. The whitening essence according to claim 7, characterized in that, The skin conditioning agent is a combination of osmanthus cell water and allantoin.

9. A method for preparing a whitening serum according to any one of claims 5-8, characterized in that, The preparation method includes the following steps: (1) Mix and heat dimethylmethoxybenzodihydropyranol, ethylhexyl methoxycinnamate and emulsifier, add some humectant to obtain the first mixture; weigh water, thickener, chelating agent and some humectant, stir and heat, homogenize to completely dissolve the solid to obtain the second mixture; (2) Mix the first mixture and the second mixture obtained in step (1), homogenize and emulsify, and then cool down; mix and homogenize with pH adjuster, residual moisturizer, ascorbic acid peptide, fibronectin, salvia extract and skin conditioner to obtain the whitening essence.

10. The method for preparing the whitening serum according to claim 9, characterized in that, The heating temperature in step (1) is independently 75-90°C.

11. The method for preparing the whitening serum according to claim 9, characterized in that, The temperature to which the temperature is cooled in step (2) is 40-50℃.

12. The method for preparing the whitening serum according to claim 9, characterized in that, The homogenization emulsification time in step (2) is 5-10 minutes.

13. The method for preparing the whitening serum according to claim 12, characterized in that, The homogenization emulsification time in step (2) is 8-10 minutes.

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