A kind of orifice-opening and hair-growing tincture for treating seborrheic alopecia

Abstract

The invention belongs to the field of medical technology, and in particular to a tincture for promoting the growth of hair and promoting the flow of blood for treating seborrheic alopecia. The tincture for promoting the growth of hair and promoting the flow of blood of the invention is made of the following raw materials in parts by weight: 4-6 parts of Sichuan pepper, 12-18 parts of angelica, 12-18 parts of calamus, 12-18 parts of safflower, 12-18 parts of processed polygonum multiflorum, 8-12 parts of ligusticum chuanxiong, 24-36 parts of raw cypress leaves, 12-18 parts of raw rhubarb, 12-18 parts of sophora flavescens, 12-18 parts of scutellaria baicalensis, 8-12 parts of ginseng, 0.8-1.2 parts of ganoderma lucidum, and 0.8-1.2 parts of asparagus cochinchinensis. The tincture for promoting the growth of hair and promoting the flow of blood of the invention has a good therapeutic effect on seborrheic alopecia and has a good application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a tincture for opening the acupoints and promoting hair growth for treating seborrheic alopecia. Background Art

[0002] Seborrheic alopecia is commonly known as "baldness", also known as seborrheic alopecia and male pattern baldness. It is a type of hair loss induced by excessive secretion of sebum, often accompanied by dandruff, greasy scalp, and obvious itching. Seborrheic alopecia often occurs in young and middle-aged men with vigorous secretion of sebaceous glands, so it is sometimes also called "male pattern baldness". Over time, the hair on both sides of the forehead and the top of the head begins to fall off, while the back of the head and the temporal parts on both sides still maintain normal hair. The speed and range of hair loss vary from person to person, and most progress slowly. Female patients mainly lose hair on the top of the head, and the hair is diffusely sparse.

[0003] The treatment of seborrheic alopecia currently relies mainly on daily diet. Various vitamins, oryzanol, desine, etc. can be used for medication. In addition, people have also tried to treat seborrheic alopecia with drugs. For example, the Chinese invention patent application "CN201710903108.5 A Chinese medicine formula for treating seborrheic alopecia and its preparation method" provides a Chinese medicine composition, which is composed of drugs such as oriental rhizome, coix seed, arborvitae leaf, cassia seed, rehmannia root, capillaris, scutellaria, phellodendron, schizonepeta, bamboo leaf, mulberry leaf, tuckahoe, julibrissin, gentian, hawthorn, cicada shell and black sesame.

[0004] However, the effects of existing diet conditioning and drug treatments vary greatly for different patients, and some patients cannot achieve ideal therapeutic effects. Therefore, it is still necessary to develop new therapeutic drugs for seborrheic alopecia. Summary of the invention

[0005] In view of the problems of the prior art, the present invention provides a tincture for treating seborrheic alopecia, aiming to provide a new medicine for treating seborrheic alopecia and to provide more options for the clinical treatment of seborrheic alopecia.

[0006] A pharmaceutical composition (tongqiao shengfa tincture) for treating seborrheic alopecia is prepared from the following raw materials in parts by weight: 4-6 parts of Sichuan pepper, 12-18 parts of angelica, 12-18 parts of calamus, 12-18 parts of safflower, 12-18 parts of processed polygonum multiflorum, 8-12 parts of chuanxiong, 24-36 parts of raw arborvitae leaves, 12-18 parts of raw rhubarb, 12-18 parts of sophora flavescens, 12-18 parts of radix spatholobi, 8-12 parts of ginseng, 0.8-1.2 parts of ganoderma lucidum and 0.8-1.2 parts of asparagus cochinchinensis.

[0007] Preferably, it is made of the following raw materials in parts by weight: 5 parts of Sichuan pepper, 15 parts of angelica, 15 parts of calamus, 15 parts of safflower, 15 parts of processed Polygonum multiflorum, 10 parts of ligusticum chuanxiong, 30 parts of raw Platycladus orientalis leaves, 15 parts of raw rhubarb, 15 parts of sophora flavescens, 15 parts of radix spatholobi, 10 parts of ginseng, 1 part of ganoderma lucidum, and 1 part of asparagus cochinchinensis.

[0008] Preferably, the pharmaceutical composition is a drug for external use.

[0009] Preferably, it is a preparation prepared by taking the native powder of the raw material, water or organic solvent extract as active ingredients, and adding pharmaceutically acceptable excipients or auxiliary ingredients.

[0010] Preferably, the preparation is a solution, tincture, powder, lotion, oil, emulsion, ointment, paste, plaster, film or gel.

[0011] The present invention also provides a method for preparing the above-mentioned pharmaceutical composition, which is characterized in that it comprises the following steps: mixing the raw materials, adding ethanol aqueous solution, soaking, and filtering through a microporous filter membrane to obtain the pharmaceutical composition.

[0012] Preferably, the concentration of the ethanol aqueous solution is 60-90%; and / or the amount of the ethanol aqueous solution is 3-7 times the amount of the raw material; and / or the soaking time is 5-9 days.

[0013] Preferably, the concentration of the ethanol aqueous solution is 75%; and / or the amount of the ethanol aqueous solution is 5 times the amount of the raw material; and / or the soaking time is 7 days.

[0014] The present invention also provides use of the pharmaceutical composition in preparing a medicine for treating seborrheic alopecia.

[0015] The present invention provides a Tongqiao Shengfa tincture for treating seborrheic alopecia. Tongqiao Shengfa tincture, combined with clinical rolling needle therapy, stimulates hair follicle growth, improves local nutrition of hair follicles, and achieves the effect of preventing hair loss and promoting hair growth. The formula of the pharmaceutical composition is as follows:

[0016] Sichuan pepper is Zanthoxylumbungeanum Maxim.

[0017] Platycladus orientalis leaves Cupressaceae Dried branches and leaves of the plant Platycladusorientalis (L.) Franco.

[0018] Raw rhubarb is the decoction piece of the original medicinal material of rhubarb.

[0019] Tongqiao Shengfa Tincture: Sichuan pepper in the recipe is warm and spicy, which can warm the spleen and stomach, treat wind evil, strengthen teeth and hair, open the pores, and dredge blood vessels. Long-term use of spicy and warm blood circulation, hair is the residue of blood, so it can nourish hair; processed Polygonum multiflorum nourishes blood and yin, nourishes liver and kidney; raw Platycladus orientalis leaves promote hair growth and blacken hair, clears heat and dries dampness; ginseng enters the spleen, lung, and heart meridians, replenishes qi and blood, and nourishes liver and kidney. The four are the main drugs. Angelica and Ganoderma lucidum replenish qi and blood, promote blood circulation and replenish blood; Acorus calamus opens the mind, refreshes the spirit, removes dampness and harmonizes the stomach; Sophora flavescens clears heat and dries dampness, and relieves itching. The four are the minister drugs, and the assistants are safflower, Chuanxiong, and Radix Pseudostellariae. Safflower and Chuanxiong promote blood circulation and remove blood stasis, and promote qi circulation; Radix Pseudostellariae dispels wind and dampness, and promotes blood circulation. Envoys: raw rhubarb and asparagus cochinchinensis. Raw rhubarb dries dampness and removes blood stasis; asparagus cochinchinensis nourishes kidney yin, nourishes yin and clears heat. Using the whole formula together can open the pores, unblock the blood vessels, remove dampness and wind, and promote hair growth and darken the hair.

[0020] Obviously, according to the above contents of the present invention, in accordance with common technical knowledge and customary means in the art, without departing from the above basic technical ideas of the present invention, other various forms of modification, replacement or change may be made.

[0021] The above contents of the present invention are further described in detail below through specific implementation methods in the form of embodiments. However, this should not be understood as the scope of the above subject matter of the present invention being limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is an example diagram of BASP classification;

[0023] Figure 2 This is a comparison chart of the treatment effects of two patients in Experimental Example 1;

[0024] Figure 3 This is a comparison chart of the treatment effects of three patients in Experimental Example 1;

[0025] Figure 4 This is a comparison chart of the treatment effects of three patients in Experimental Example 1. DETAILED DESCRIPTION

[0026] Embodiment 1: Orifice-opening and hair-growing tincture

[0027] Tincture made from the following ingredients: 5g Sichuan pepper, 15g angelica, 15g Acorus calamus, 15g safflower, 15g processed Polygonum multiflorum, 10g Chuanxiong, 30g raw Platycladus orientalis leaves, 15g raw rhubarb, 15g Sophora flavescens, 15g Polygonum aviculare, 10g ginseng, 1g Ganoderma lucidum, and 1g Asparagus cochinchinensis.

[0028] The preparation method of the tincture is as follows: mix the raw materials, add 5 times the amount of 75% ethanol, soak for 7 days, filter through a 0.22 μm organic nylon microporous filter membrane, and obtain the tincture.

[0029] Directions for use: For external use, once in the morning and once in the evening.

[0030] Embodiment 2: Tongqiao Shengfa Tincture

[0031] A tincture made from the following ingredients: 4g Sichuan pepper, 18g angelica, 18g calamus, 18g safflower, 18g processed Polygonum multiflorum, 12g Chuanxiong, 36g raw Platycladus orientalis leaves, 18g raw rhubarb, 18g Sophora flavescens, 18g Polygonum aviculare, 12g ginseng, 1.2g Ganoderma lucidum, and 1.2g Asparagus cochinchinensis.

[0032] The preparation method of the tincture is as follows: mix the raw materials, add 5 times the amount of 75% ethanol, soak for 7 days, filter through a 0.22 μm organic nylon microporous filter membrane, and obtain the tincture.

[0033] Directions for use: For external use, once in the morning and once in the evening.

[0034] Example 3: Orifice-opening and hair-growing tincture

[0035] A tincture made from the following ingredients: 6g of Sichuan pepper, 12g of angelica, 12g of calamus, 12g of safflower, 12g of processed Polygonum multiflorum, 8g of chuanxiong, 24g of raw Platycladus orientalis leaves, 12g of raw rhubarb, 12g of Sophora flavescens, 12g of Radix scutellariae, 8g of ginseng, 0.8g of Ganoderma lucidum, and 0.8g of Asparagus cochinchinensis.

[0036] The preparation method of the tincture is as follows: mix the raw materials, add 5 times the amount of 75% ethanol, soak for 7 days, filter through a 0.22 μm organic nylon microporous filter membrane, and obtain the tincture.

[0037] Directions for use: For external use, once in the morning and once in the evening.

[0038] The technical solution of the present invention is further illustrated by experiments below.

[0039] Experimental Example 1 The therapeutic effect of Tongqiao Shengfa tincture on seborrheic alopecia

[0040] 1. Experimental Methods

[0041] 1. Diagnostic criteria for seborrheic alopecia

[0042] Seborrheic alopecia, also known as androgenic alopecia, is mainly characterized by thinning and thinning of the hair, often accompanied by increased scalp oil secretion, progressive development, decreased hair density, atrophy of hair follicles, disappearance of vellus hair, until the scalp in the hair loss area becomes shiny.

[0043] 2. Case scoring table

[0044] The following case scoring table was used to score cases and collect indicators:

[0045] BASP classification:

[0046] M1□ M2□ M3□ C1□ C2□ C3□ V1□ V2□ F1□ F2□ (Examples of each classification are as follows Figure 1 (shown)

[0047] Have you taken medication for this disease in the past 6 months: Yes □ No □

[0048] Are there other diseases: Yes □ No □

[0049] History of drug allergy: No □ Yes □

[0050] Family history: No □ Yes □

[0051] Pressure size: Smaller □ Larger □

[0052] Sleep disorder: No □ Yes □

[0053] Food preference: Normal □ Spicy □ Greasy □ Sweet □

[0054] Adverse reactions: None □ Yes □

[0055] Table 1 Main observation index score table

[0056]

[0057]

[0058] 3. Treatment methods

[0059] The Tongqiao Shengfa tincture of Example 1 or Example 3 is used externally, once in the morning and once in the evening, for 3 months.

[0060] 2. Case Data and Treatment Effects

[0061] The indicators of the 10 cases before and after treatment are shown in Table 2. The hair photos or scalp dermoscopic photos before and after treatment are shown in Table Figure 2 shown.

[0062] Table 2

[0063]

[0064]

[0065] From Table 2, Figure 2 From the data, we can see that after using the Tongqiao Shengfa Tincture, the itching, oiliness, scaling and other symptoms were significantly improved, and hair loss was reduced, which has the effect of hair growth.

[0066] It can be seen from the above embodiments that the present invention provides a new drug for treating seborrheic alopecia, which provides more options for the clinical treatment of seborrheic alopecia.

Claims

1. A topical pharmaceutical composition for treating seborrheic alopecia, characterized in that: The invention is prepared from the following raw materials in parts by weight: 4-6 parts of Sichuan pepper, 12-18 parts of angelica, 12-18 parts of calamus, 12-18 parts of safflower, 12-18 parts of processed polygonum multiflorum, 8-12 parts of chuanxiong, 24-36 parts of raw arborvitae leaves, 12-18 parts of raw rhubarb, 12-18 parts of sophora flavescens, 12-18 parts of radix spatholobi, 8-12 parts of ginseng, 0.8-1.2 parts of ganoderma lucidum and 0.8-1.2 parts of asparagus cochinchinensis.

2. The external pharmaceutical composition according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 5 parts of Sichuan pepper, 15 parts of angelica, 15 parts of calamus, 15 parts of safflower, 15 parts of processed polygonum multiflorum, 10 parts of chuanxiong, 30 parts of raw arborvitae leaves, 15 parts of raw rhubarb, 15 parts of sophora flavescens, 15 parts of radix spatholobi, 10 parts of ginseng, 1 part of ganoderma lucidum and 1 part of asparagus cochinchinensis.

3. The external pharmaceutical composition according to claim 1 or 2, characterized in that: The preparation is prepared by adding pharmaceutically acceptable auxiliary materials or auxiliary components into the original powder of the raw materials, water or organic solvent extract as active ingredients.

4. The external pharmaceutical composition according to claim 3, characterized in that: The preparation is a tincture, powder, oil, emulsion, ointment, paste, plaster, film or gel.

5. The method for preparing the external pharmaceutical composition according to any one of claims 1 to 4, characterized in that: The method comprises the following steps: mixing raw materials, adding ethanol aqueous solution, soaking, and filtering through a microporous filter membrane to obtain the product.

6. The preparation method according to claim 5, characterized in that: The concentration of the ethanol aqueous solution is 60-90%; and / or the amount of the ethanol aqueous solution is 3-7 times the amount of the raw material; and / or the soaking time is 5-9 days.

7. The preparation method according to claim 6, characterized in that: The concentration of the ethanol aqueous solution is 75%; and / or, the amount of the ethanol aqueous solution is 5 times the amount of the raw material; and / or, the soaking time is 7 days.

8. Use of the external pharmaceutical composition according to any one of claims 1 to 4 in the preparation of a medicament for treating seborrheic alopecia.

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