A quick-setting magnesium oxychloride bone cement, its preparation method and application

Abstract

The application provides a quick-setting magnesium oxychloride bone cement as well as a preparation method and application thereof. The raw material composition of the quick-setting magnesium oxychloride bone cement comprises a solid phase and a liquid phase; the solid phase comprises magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate; and the liquid phase is water. The mass ratio of zinc chloride to magnesium chloride is (1-2):(9-8); the mass of strontium hydrogen phosphate is 3-5 wt.% of the total weight of magnesium oxide, magnesium chloride and zinc chloride. The ratio of the total mass of zinc chloride and magnesium chloride to the mass of water is 1:11-17; and the ratio of the total mass of zinc chloride and magnesium chloride to the mass of magnesium oxide is 1:6-9. The composite magnesium oxychloride bone cement prepared by the application has a suitable setting time, is convenient for clinical operation, has a high compressive strength, meets the strength requirement of dense bone, and can be used for bone repair of load-bearing parts.

Description

Technical Field

[0001] This invention belongs to the field of biomedical materials technology, specifically relating to a fast-setting magnesium oxychloride bone cement, its preparation method, and its application. Background Technology

[0002] Aging, traffic accidents, and tumors can all cause bone defects. While bone itself has a certain self-repairing ability, when the defect exceeds a critical size, bone repair materials are needed for repair. Autologous bone is the best bone repair material, but its source is limited, and for the elderly, bone harvesting surgery may cause secondary trauma. Allogeneic bone may cause immune rejection. Therefore, an artificial bone repair material with good bioactivity and excellent mechanical properties is needed.

[0003] Bone cement has received widespread attention and research due to its excellent self-curing and malleability. However, currently used bone cements all have their own drawbacks. For example, polymethyl methacrylate (PMMA) bone cement releases a large amount of heat during curing, which can easily burn surrounding tissues and is cytotoxic. Calcium phosphate (CMP) bone cement, due to its ability to form hydroxyapatite after solidification and its ability to form a bony bond with bone tissue, exhibits good bioactivity and biocompatibility; however, it also suffers from poor adhesion and low mechanical strength. Magnesium phosphate (MgP) bone cement has good mechanical properties, degradability, and bioactivity; however, its short setting time and rapid heat release limit its clinical use. Calcium sulfate (MSP) bone cement has good biocompatibility, osteoconductivity, and can promote bone healing, but its rapid degradation and poor mechanical properties also limit its application.

[0004] Magnesium oxychloride cement (MOC) is a ternary composite system consisting of active MgO, MgCl2, and H2O. MOC possesses advantages such as good mechanical properties, good biocompatibility, and short setting time; however, excessively rapid setting can reduce its mechanical properties. Therefore, further research and development of bone cements with suitable setting times and high compressive strength is of significant clinical importance.

[0005] Therefore, there is a need to provide an improved technical solution that addresses the shortcomings of the existing technology. Summary of the Invention

[0006] To address the shortcomings of existing technologies, the present invention aims to provide a fast-setting magnesium oxychloride bone cement with high compressive strength and short setting time, as well as its preparation method and application.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] This invention provides a fast-setting magnesium oxychloride bone cement, the raw material composition of which includes a solid phase and a liquid phase; the solid phase includes magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate; the liquid phase is water.

[0009] Preferably, the molar ratio of zinc chloride to magnesium chloride is (1-2):(9-8); the mass of strontium hydrogen phosphate is 3-5 wt.% of the total weight of magnesium oxide, magnesium chloride, and zinc chloride.

[0010] More preferably, the molar ratio of zinc chloride to magnesium chloride is (1-1.75):(9-8.25); and the mass of strontium hydrogen phosphate is 4.0 wt.% of the total weight of magnesium oxide, magnesium chloride, and zinc chloride.

[0011] More preferably, the molar ratio of zinc chloride to magnesium chloride is 1.25:8.75.

[0012] Preferably, the ratio of the total amount of zinc chloride and magnesium chloride to the amount of water is 1:11-17; and the ratio of the total amount of zinc chloride and magnesium chloride to the amount of magnesium oxide is 1:6-9.

[0013] More preferably, the ratio of the total amount of zinc chloride and magnesium chloride to the amount of water is 1:13; and the ratio of the total amount of zinc chloride and magnesium chloride to the amount of magnesium oxide is 1:8.

[0014] This invention provides a method for preparing the aforementioned quick-setting magnesium oxychloride bone cement, comprising the following steps:

[0015] (1) Weigh out water, magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate according to the composition of raw materials, and set aside;

[0016] (2) Add magnesium chloride and zinc chloride to water in sequence and stir until well mixed to obtain a solution;

[0017] (3) Add strontium hydrogen phosphate to the solution and stir until homogeneous to obtain a suspension;

[0018] (4) Add magnesium oxide to the suspension and stir for 3 minutes to obtain the solution.

[0019] This invention provides an application of the aforementioned quick-setting magnesium oxychloride bone cement in bone repair materials.

[0020] Beneficial effects:

[0021] This invention replaces magnesium chloride in magnesium oxychloride cement with zinc chloride at different molar ratios, then adds both to ultrapure water, followed by the addition of strontium hydrogen phosphate to form a suspension. Magnesium oxide powder is then added to the suspension to investigate and determine the optimal zinc chloride / magnesium chloride molar ratio for magnesium oxychloride bone cement. The composite magnesium oxychloride bone cement prepared by this invention has a suitable setting time, facilitating clinical application; it also possesses high compressive strength, making it suitable for bone repair in load-bearing areas. Attached Figure Description

[0022] The accompanying drawings, which form part of this application, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention. Wherein:

[0023] Figure 1 The diagram shows the compressive strength and softening coefficient of magnesium oxychloride bone cement samples with different amounts of strontium hydrogen phosphate after being immersed in SBF solution for different periods.

[0024] Figure 2 The graph shows the initial and final setting times of magnesium oxychloride bone cement with different zinc chloride content.

[0025] Wherein, 0∶10 is Comparative Example 1, 1∶9 is Example 1, 1.25∶8.75 is Example 2, 1.5∶8.5 is Example 3, 1.75∶8.25 is Example 4, and 2∶8 is Comparative Example 2; the vertical axis is the condensation time in minutes.

[0026] Figure 3 The figure shows the test results of compressive strength of magnesium oxychloride bone cement with different zinc chloride content.

[0027] Wherein, 0∶10 is Comparative Example 1, 1∶9 is Example 1, 1.25∶8.75 is Example 2, 1.5∶8.5 is Example 3, 1.75∶8.25 is Example 4, and 2∶8 is Comparative Example 2; the vertical axis represents compressive strength, in MPa.

[0028] Figure 4 The X-ray diffraction patterns are those of the magnesium oxychloride bone cement curing products obtained in Examples 1, 2 and Comparative Example 1.

[0029] Wherein, 0:10 is Comparative Example 1, 1:9 is Example 1, and 1.25:8.75 is Example 2.

[0030] Figure 5 The graph shows the compressive strength test results of the magnesium oxychloride bone cement obtained in Example 2 and Comparative Examples 3, 4 and 5.

[0031] Among them, 8-1-17 is Comparative Example 5, 8-1-15 is Comparative Example 4, 8-1-13 is Example 2, and 8-1-11 is Comparative Example 3; the vertical axis represents compressive strength in MPa.

[0032] Figure 6 The graph shows the initial setting time and final setting time of the magnesium oxychloride bone cement obtained in Example 2 and Comparative Examples 3, 4 and 5.

[0033] Among them, 8-1-17 is Comparative Example 5, 8-1-15 is Comparative Example 4, 8-1-13 is Example 2, and 8-1-11 is Comparative Example 3; the vertical axis represents the condensation time in minutes.

[0034] Figure 7 The graph shows the compressive strength test results of the magnesium oxychloride bone cement obtained in Example 2 and Comparative Examples 6, 7, and 8.

[0035] Wherein, 6-1-13 is Comparative Example 6, 7-1-13 is Comparative Example 7, 8-1-13 is Example 2, and 9-1-13 is Comparative Example 8; the vertical axis represents compressive strength, in MPa.

[0036] Figure 8 The graph shows the initial and final setting times of the magnesium oxychloride bone cement obtained in Example 2 and Comparative Examples 6, 7, and 8.

[0037] Wherein, 6-1-13 is Comparative Example 6, 7-1-13 is Comparative Example 7, 8-1-13 is Example 2, and 9-1-13 is Comparative Example 8; the vertical axis represents the solidification time in minutes. Detailed Implementation

[0038] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention are within the scope of protection of the present invention.

[0039] The present invention will now be described in detail with reference to embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in the embodiments of the present invention can be combined with each other.

[0040] This invention addresses the existing problems by providing a fast-setting magnesium oxychloride bone cement with high compressive strength and short setting time. The raw material composition includes a solid phase and a liquid phase; the solid phase includes magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate; the liquid phase is water.

[0041] This invention utilizes zinc chloride to replace part of the magnesium chloride, which can promote the hydration reaction of magnesium oxychloride cement and shorten the setting time of magnesium oxychloride cement.

[0042] In a preferred embodiment of the present invention, the molar ratio of zinc chloride to magnesium chloride is (1-2):(9-8) (e.g., 1:9, 1.25:8.75, 1.5:8.5, 1.75:8.25 or 2:8); the mass of strontium hydrogen phosphate is 3-5 wt.% of the total mass of magnesium oxide, magnesium chloride and zinc chloride (e.g., 3.0 wt.%, 3.5 wt.%, 4.0 wt.%, 4.5 wt.% or 5.0 wt.%).

[0043] In a preferred embodiment of the present invention, the molar ratio of zinc chloride to magnesium chloride is (1-1.75):(9-8.25) (e.g., 1:9, 1.25:8.75, 1.5:8.5, or 1.75:8.25); the mass of strontium hydrogen phosphate is 4.0 wt.% of the total mass of magnesium oxide, magnesium chloride, and zinc chloride.

[0044] Strontium hydrogen phosphate is added to magnesium oxychloride cement as a water-resistant admixture. According to previous experiments, when the admixture dosage is 4.0 wt.%, magnesium oxychloride bone cement has good compressive strength and water resistance.

[0045] In a preferred embodiment of the present invention, the molar ratio of zinc chloride to magnesium chloride is 1.25:8.75.

[0046] In a preferred embodiment of the present invention, the ratio of the total amount of zinc chloride and magnesium chloride to the amount of water is 1:11-17 (e.g., 1:11, 1:13, 1:15 or 1:17); the ratio of the total amount of zinc chloride and magnesium chloride to the amount of magnesium oxide is 1:6-9 (e.g., 1:6, 1:7, 1:8 or 1:9).

[0047] In a preferred embodiment of the present invention, the ratio of the total amount of zinc chloride and magnesium chloride to the amount of water is 1:13; and the ratio of the total amount of zinc chloride and magnesium chloride to the amount of magnesium oxide is 1:8.

[0048] This invention provides a method for preparing the aforementioned quick-setting magnesium oxychloride bone cement, comprising the following steps:

[0049] (1) Weigh out water, magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate according to the composition of raw materials, and set aside;

[0050] (2) Add magnesium chloride and zinc chloride to water in sequence and stir until well mixed to obtain a solution;

[0051] (3) Add strontium hydrogen phosphate to the solution and stir until homogeneous to obtain a suspension;

[0052] (4) Add magnesium oxide to the suspension and stir for 3 minutes to obtain the solution.

[0053] This invention provides an application of the aforementioned quick-setting magnesium oxychloride bone cement in bone repair materials.

[0054] The following detailed description of a fast-setting magnesium oxychloride bone cement, its preparation method, and its application is illustrated by specific embodiments.

[0055] The raw materials used in the following examples:

[0056] The water was ultrapure water; the magnesium chloride was magnesium chloride hexahydrate (Tianjin Kemeio Chemical Reagent Co., Ltd.), analytical grade; the zinc chloride (Tianjin Hedong Hongyan Reagent Factory) was analytical grade; and the strontium hydrogen phosphate (Shanghai Maclean Biochemical Technology Co., Ltd.) was analytical grade.

[0057] Magnesium oxide was obtained by calcining analytical grade magnesium hydroxide (Biode Pharmaceutical) in a muffle furnace at 500°C for 3 hours.

[0058] The activity of magnesium oxide varies depending on the calcination temperature of magnesium hydroxide, with higher activity magnesium oxide content at certain calcination temperatures.

[0059] Example 1

[0060] This embodiment provides a fast-setting magnesium oxychloride bone cement, the raw material composition of which includes a solid phase and a liquid phase; the solid phase includes magnesium oxide (MgO), magnesium chloride (MgCl2), zinc chloride (ZnCl2) and strontium hydrogen phosphate (SrHPO4); the liquid phase is water (H2O).

[0061] The molar ratio of ZnCl2 to MgCl2 is 1:9; the molar ratio of the total amount of ZnCl2 and MgCl2 to the amount of H2O is 1:13; the molar ratio of MgO to the total amount of ZnCl2 and MgCl2 is 8:1; and the mass of SrHPO4 is 4.0 wt.% of the total mass of MgO, MgCl2, and ZnCl2.

[0062] The preparation method of this quick-setting magnesium oxychloride bone cement includes the following steps:

[0063] (1) Weigh out water, magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate according to the composition of raw materials, and set aside;

[0064] (2) Add magnesium chloride and zinc chloride to water in sequence and stir until well mixed to obtain a solution;

[0065] (3) Add strontium hydrogen phosphate to the solution and stir until homogeneous to obtain a milky white suspension;

[0066] (4) Add magnesium oxide to the suspension and stir for 3 minutes to obtain magnesium oxychloride bone cement paste.

[0067] The amount of SrHPO4 added was determined based on previous experiments. The compressive strength and softening coefficient of magnesium oxychloride bone cement samples with different amounts of SrHPO4 were measured after being soaked in SBF solution (simulated body fluid) for different periods (1d, 7d, 14d, 28d, 56d, and 84d, respectively).

[0068] The raw material composition of magnesium oxychloride bone cement samples is magnesium oxide (MgO), magnesium chloride (MgCl2), strontium hydrogen phosphate (SrHPO4), and water (H2O); the molar ratio of MgO, MgCl2, and H2O is 8:1:15; the mass of SrHPO4 is 0-5 wt.% of the total weight of MgO and MgCl2 (0 wt.%, 3.0 wt.%, 3.5 wt.%, 4.0 wt.%, 4.5 wt.%, and 5.0 wt.%, respectively). Magnesium oxychloride bone cement samples with different amounts of strontium hydrogen phosphate were obtained using the above preparation method.

[0069] Experimental results are as follows Figure 1 As shown, the water resistance of magnesium oxychloride bone cement is evaluated by its softening coefficient; the higher the softening coefficient, the better the water resistance. Figure 1 It can be seen that when the admixture content is 4.0 wt.%, magnesium oxychloride bone cement has good compressive strength and water resistance.

[0070] Example 2

[0071] This embodiment provides a quick-setting magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 1 is that the molar ratio of ZnCl2 to MgCl2 is 1.25:8.75, and the other composition and preparation method are the same as those of Example 1.

[0072] Example 3

[0073] This embodiment provides a fast-setting magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 1 is that the molar ratio of ZnCl2 to MgCl2 is 1.5:8.5, and the other composition and preparation method are the same as those of Example 1.

[0074] Example 4

[0075] This embodiment provides a quick-setting magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 1 is that the molar ratio of ZnCl2 to MgCl2 is 1.75:8.25, and the other composition and preparation method are the same as those of Example 1.

[0076] Comparative Example 1

[0077] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 1 is that the molar ratio of ZnCl2 to MgCl2 is 0:10 (i.e. no ZnCl2 is added), while the other composition and preparation method are the same as in Example 1.

[0078] Comparative Example 2

[0079] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 1 is that the molar ratio of ZnCl2 to MgCl2 is 2:8, while the other composition and preparation method are the same as in Example 1.

[0080] Comparative Example 3

[0081] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 2 is that the total amount of ZnCl2 and MgCl2 to the amount of H2O is 1:11, and the other composition and preparation method are the same as those of Example 2.

[0082] Comparative Example 4

[0083] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 2 is that the total amount of ZnCl2 and MgCl2 to the amount of H2O is 1:15, and the other composition and preparation method are the same as those of Example 2.

[0084] Comparative Example 5

[0085] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 2 is that the total amount of ZnCl2 and MgCl2 to the amount of H2O is 1:17, and the other composition and preparation method are the same as those of Example 2.

[0086] Comparative Example 6

[0087] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 2 is that the ratio of the amount of MgO to the total amount of ZnCl2 and MgCl2 is 6:1, while the other composition and preparation method are the same as in Example 2.

[0088] Comparative Example 7

[0089] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 2 is that the ratio of the amount of MgO to the total amount of ZnCl2 and MgCl2 is 7:1, while the other composition and preparation method are the same as in Example 2.

[0090] Comparative Example 8

[0091] This comparative example provides a magnesium oxychloride bone cement, the only difference between its raw material composition and that of Example 2 is that the ratio of the amount of MgO to the total amount of ZnCl2 and MgCl2 is 9:1, while the other composition and preparation method are the same as in Example 2.

[0092] Application Example 1

[0093] (1) The setting time of the cement pastes obtained in Examples 1-4 and Comparative Examples 1-8 was tested using a Vicat apparatus at 37°C. The experimental results are shown in Table 1 below. Figure 2 , 6 As shown in Figure 8.

[0094] (2) Test using a universal testing machine (loading speed 1 mm / min) -1 The compressive strength of the cement pastes obtained in Examples 1-4 and Comparative Examples 1-8 after curing in a curing chamber at 37°C and 80% humidity for 24 hours is shown in Table 1 below. Figure 3 , 5 As shown in Figures 7 and 8.

[0095] The specific method is as follows: 1) Fill the cement slurry into a 10mm×10mm×10mm cube mold; 2) Place the mold in a constant temperature and humidity chamber for curing. The curing temperature is 37℃, the curing humidity is 80%, and the curing time is 24h; 3) Demold the cured bone cement sample and set it aside.

[0096] Table 1

[0097] Group Initial setting time / min Final setting time / min Compressive strength / MPa Example 1 52 62 122.2 Example 2 30 45 98.5 Example 3 25 35 89.1 Example 4 20 35 82.8 Comparative Example 1 65 75 115.1 Comparative Example 2 10 15 65.5 Comparative Example 3 65 75 72.7 Comparative Example 4 100 120 65.2 Comparative Example 5 115 130 59.9 Comparative Example 6 110 120 78 Comparative Example 7 70 95 83.1 Comparative Example 8 55 70 78.5

[0098] The results showed that the addition of ZnCl2 significantly affected the setting time of magnesium oxychloride bone cement. Examples 1-4 showed that as the proportion of ZnCl2 replacing MgCl2 increased, both the initial and final setting times decreased. However, the compressive strength initially increased and then decreased with increasing ZnCl2 substitution ratio. This change in compressive strength is due to the initial enhancement and subsequent decrease of the characteristic peaks of the five phases after the addition of zinc chloride. The five phases are the main source of strength in magnesium oxychloride cement; the more of the five phases present, the higher the strength. The setting time of magnesium oxychloride bone cement is inversely proportional to its hydration reaction rate; that is, the faster the hydration reaction rate, the shorter the setting time. The incorporation of zinc chloride shortens the setting time, possibly by promoting the dissolution of magnesium oxide, accelerating the diffusion rate of magnesium ions, and promoting the hydration reaction. This is consistent with the results observed in Example 1 and Comparative Example 1. The intensity of the characteristic peak of magnesium oxide decreases after the addition of zinc chloride; however, with the increase of zinc chloride content, the intensity of the characteristic peak of magnesium oxide increases. This may be because the setting time is too short, resulting in a large amount of unreacted magnesium oxide, leading to a decrease in the intensity of the characteristic peaks of the five phases, and the compressive strength of magnesium oxychloride bone cement also decreases accordingly. Specifically, when the substitution ratio of ZnCl2 is 1.25 (Example 2), its initial setting time and final setting time are 30 min and 45 min, respectively, and the compressive strength is 98.5 MPa, which meets the requirements for dense bone.

[0099] As can be seen from Examples 1, 1 Comparative Example, and 2, replacing MgCl2 with ZnCl2 (Example 1) is beneficial to the setting time of magnesium oxychloride bone cement compared to not using ZnCl2 to replace MgCl2 (Example 1). However, if the ZnCl2 substitution ratio is too high (Comparative Example 2), the setting time of magnesium oxychloride bone cement is too short, which is not conducive to clinical operation and reduces compressive strength. This is because if the setting time is too short, a large amount of magnesium oxide fails to react, reducing the formation of phase V and leading to a decrease in the strength of magnesium oxychloride bone cement.

[0100] As can be seen from Examples 2 and Comparative Examples 3, 4, 5, 6, 7, and 8, the molar ratio of magnesium oxychloride bone cement at 8:1:13 exhibits higher strength and a shorter setting time. This is because when the molar ratio of MgO to the total molar ratio of ZnCl2 and MgCl2 is low, a three-phase structure is formed, reducing its compressive strength; conversely, when the molar ratio of MgO to the total molar ratio of ZnCl2 and MgCl2 is too high, a large amount of unreacted MgO is produced, leading to a decrease in strength. Similarly, when the molar ratio of the total molar ratio of ZnCl2 and MgCl2 to the molar ratio of H2O is too high, on the one hand, magnesium hydroxide is generated, consuming MgO and reducing the amount of MgO available for the formation of the five-phase structure, thus affecting strength; on the other hand, excess unreacted H2O also generates pores, affecting strength. Conversely, when the ratio decreases, the concentration of MgCl2 increases, leading to the formation of the three-phase structure, which also reduces compressive strength. Regarding the setting time, from... Figure 8 It can be seen that as the ratio of the amount of MgO to the total amount of ZnCl2 and MgCl2 increases, the setting time first shortens and then lengthens. This is because the increased amount of MgO powder increases the contact area between the particles and the MgCl2 solution, promoting the reaction. However, when the ratio is too high, the reaction is faster, but the rapid reaction generates a large amount of hydration products. These hydration products coat the unhydrated MgO particles, hindering the reaction. The same reason applies to changing the ratio of the total amount of ZnCl2 and MgCl2 to the amount of H2O. Increasing or decreasing the corresponding proportion of H2O means decreasing or increasing the amount of MgO. Therefore, as the proportion decreases, the setting time shows a trend of first shortening and then lengthening, reaching its shortest value in 8-1-13 (Example 2).

[0101] (3) X-ray diffraction analysis was performed on the magnesium oxychloride bone cement curing products obtained in Examples 1, 2 and Comparative Example 1, respectively. The obtained X-ray diffraction patterns are as follows: Figure 4 As shown. By Figure 4 It can be seen that before and after the addition of ZnCl2, the main components of magnesium oxychloride bone cement are both five phases (5Mg(OH)2·MgCl2·8H2O) and magnesium oxide. The addition of ZnCl2 did not change the phase composition of magnesium oxychloride cement, but the intensity of the characteristic peaks changed. The intensity of the five phases first increased and then decreased. The more five phases there are, the higher the strength of magnesium oxychloride cement.

[0102] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A quick-setting magnesium oxychloride bone cement, characterized in that, The raw material composition includes a solid phase and a liquid phase; the solid phase includes magnesium oxide, magnesium chloride, zinc chloride, and strontium hydrogen phosphate; the liquid phase is water; The molar ratio of zinc chloride to magnesium chloride is (1-1.75):(8.25-9); the mass of strontium hydrogen phosphate is 4 wt.% of the total mass of magnesium oxide, magnesium chloride and zinc chloride; the molar ratio of the total amount of zinc chloride and magnesium chloride to water is 1:13; the molar ratio of the total amount of zinc chloride and magnesium chloride to magnesium oxide is 1:

8.

2. The quick-setting magnesium oxychloride bone cement as described in claim 1, characterized in that, The molar ratio of zinc chloride to magnesium chloride is 1.25:8.

75.

3. The method for preparing quick-setting magnesium oxychloride bone cement as described in any one of claims 1-2, characterized in that, Includes the following steps: (1) Weigh out water, magnesium oxide, magnesium chloride, zinc chloride and strontium hydrogen phosphate according to the composition of raw materials, and set aside; (2) Add magnesium chloride and zinc chloride to water in sequence, stir well to obtain a solution; (3) Add strontium hydrogen phosphate to the solution and stir until homogeneous to obtain a suspension; (4) Add magnesium oxide to the suspension and stir for 3 minutes to obtain the solution.

4. The application of the quick-setting magnesium oxychloride bone cement as described in any one of claims 1-2 in bone repair materials.

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