A traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae disease in chickens and its application

Abstract

The present invention provides a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application, which relates to the technical field of veterinary drugs. The traditional Chinese medicine preparation comprises the following traditional Chinese medicine components in parts by weight: 10-20 parts of Eucommia ulmoides leaves, 5-13 parts of Psoralea corylifolia, 3-10 parts of Cortex Lycii, 3-10 parts of Corydalis yanhusuo, 2-8 parts of Bupleurum chinense, 5-13 parts of Paeonia lactiflora, 3-10 parts of Platycodon grandiflorum, 2-8 parts of Curcuma aromatica, 2-8 parts of Glycyrrhiza uralensis, 3-10 parts of Cinnamomum cassia, 2-8 parts of Zingiber officinale, 5-12 parts of Achyranthes bidentata, 2-8 parts of Atractylodes lancea, and 5-13 parts of Polyporus umbellatus. The traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application are obtained by reasonably compatibility of fourteen Chinese herbal medicines such as Eucommia ulmoides leaves, Psoralea corylifolia, Cortex Lycii, Bupleurum chinense, Paeonia lactiflora, and Platycodon grandiflorum according to the principle of syndrome differentiation and treatment in traditional Chinese medicine, giving full play to the functions of each medicine, and the medicines jointly coordinate to enhance the drug effect. It has the effects of promoting blood circulation to remove blood stasis, strengthening tendons and relieving arthralgia, dredging meridians and dispelling cold, and removing dampness and reducing swelling. Through clinical trials, it is proved that the traditional Chinese medicine preparation of the present invention has a definite curative effect in preventing and treating Mycoplasma synoviae in chickens. Using the traditional Chinese medicine preparation of the present invention can significantly improve the health status of chickens, increase the egg production rate, and reduce the broken egg rate. And the present invention is made of natural traditional Chinese medicine, with strong pertinence, remarkable curative effect, no drug resistance, and no drug residue, which is more beneficial to human food safety and beneficial to human health.

Description

Technical Field

[0001] The present invention relates to the technical field of veterinary drugs, and specifically to a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application. Background Art

[0002] Mycoplasma synoviae in chickens is a chronic or acute infectious disease caused by infection with Mycoplasma synoviae, also known as infectious synovitis in chickens. Diseased chickens mainly have the synovial membrane and tendon sheath membrane of joints infected by the bacteria, resulting in joint swelling, synovitis, tenosynovitis, and subclinical upper respiratory tract infection, causing a low survival rate of the chicken flock and a decrease in egg production rate of laying hens, causing irreparable losses to chicken farming production, seriously affecting the economic benefits of farm households, and damaging the development of the chicken farming industry. Clinically, this disease is usually prevented and treated with Western medicine antibiotics, which does not conform to the general trend of antibiotic-free farming, and is prone to recurrence and the problem of antibiotic residues in meat and egg products, posing a potential risk to people's health.

[0003] Natural Chinese herbal medicines have attracted attention due to their diverse functions, non-toxic side effects, and non-antibiotic resistance. Traditional Chinese veterinary medicine pays more attention to the overall and local conditioning of laying hens, and can also provide laying hens with various nutrients such as amino acids, vitamins, and natural bioactive substances such as polysaccharides, flavonoids, and alkaloids, which can enhance the body's immunity, solve the problem of antibiotic residues, effectively control the development and spread of diseases, keep animals healthy, and provide people with green and pollution-free high-quality egg products. Therefore, it plays an important role in the breeding industry. Unfortunately, there is currently no traditional Chinese veterinary medicine ready-made preparation for preventing and treating Mycoplasma synoviae in chickens on the clinical market. Therefore, there is an urgent need for a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens with definite curative effect, green economy, no antibiotics, and no toxic side effects. Summary of the Invention

[0004] (I) Technical Problems to be Solved

[0005] Aiming at the deficiencies of the prior art, the present invention provides a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application, which has the advantages of definite curative effect, green economy, no antibiotics, and no toxic side effects.

[0006] (II) Technical Solutions

[0007] To achieve the above-mentioned purposes of definite curative effect, green economy, no antibiotics and no toxic side effects, the present invention provides the following technical solutions: a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application, comprising raw materials in the following weight parts ratio: 10-20 parts of Eucommia ulmoides leaves, 5-13 parts of Psoralea corylifolia, 3-10 parts of Cortex Lycii, 3-10 parts of Corydalis yanhusuo, 2-8 parts of Bupleurum chinense, 5-13 parts of Paeonia lactiflora, 3-10 parts of Platycodon grandiflorum, 2-8 parts of Curcuma aromatica, 2-8 parts of Glycyrrhiza uralensis, 3-10 parts of Ramulus Cinnamomi, 2-8 parts of Dry Ginger, 5-12 parts of Achyranthes bidentata, 2-8 parts of Atractylodes lancea, 5-13 parts of Polyporus umbellatus. Preferably, the traditional Chinese medicine components in parts by weight are: 14 parts of Eucommia ulmoides leaves, 8 parts of Psoralea corylifolia, 7 parts of Cortex Lycii, 7 parts of Corydalis yanhusuo, 5 parts of Bupleurum chinense, 8 parts of Paeonia lactiflora, 7 parts of Platycodon grandiflorum, 5 parts of Curcuma aromatica, 5 parts of Glycyrrhiza uralensis, 7 parts of Ramulus Cinnamomi, 5 parts of Dry Ginger, 8 parts of Achyranthes bidentata, 5 parts of Atractylodes lancea, 8 parts of Polyporus umbellatus.

[0008] Preferably, the dosage form of the traditional Chinese medicine preparation is an aqueous solution or a granule.

[0009] A preparation method of a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens, comprising the following steps:

[0010] Step 1: Weigh each traditional Chinese medicine component according to the weight parts: 14 parts of Eucommia ulmoides leaves, 8 parts of Psoralea corylifolia, 7 parts of Cortex Lycii, 7 parts of Corydalis yanhusuo, 5 parts of Bupleurum chinense, 8 parts of Paeonia lactiflora, 7 parts of Platycodon grandiflorum, 5 parts of Curcuma aromatica, 5 parts of Glycyrrhiza uralensis, 7 parts of Ramulus Cinnamomi, 5 parts of Dry Ginger, 8 parts of Achyranthes bidentata, 5 parts of Atractylodes lancea, 8 parts of Polyporus umbellatus;

[0011] Step 2: Wash the raw materials weighed in the above step 1 with clean water, dry the washed raw materials and crush them into powders, and use a stirrer to mix the powders of various raw materials evenly to obtain a crude traditional Chinese medicine powder;

[0012] Step 3: Put the crude traditional Chinese medicine powder obtained in step 2 into an extraction tank, add water to carry out warm soaking on the crude traditional Chinese medicine powder at 70 °C, and the warm soaking time is 30 minutes;

[0013] Step 4: Decoct the warm-soaked crude traditional Chinese medicine powder obtained in the above step 3 three times with water, each time for 2 hours, then combine the decoction liquids and let them stand for 12 hours;

[0014] Step 5: Filter the decoction liquid that has stood well in step 4, and concentrate the filtrate to a relative density of 1.2-1.3 (measured at 80 °C), and cool it to room temperature for standby;

[0015] Step 6: Add an appropriate amount of sodium benzoate to the concentrated filtrate obtained in step 5, dissolve and mix it evenly, and then fill it to obtain the aqueous solution of the traditional Chinese medicine preparation of the present invention;

[0016] Step 7: Spray-dry the concentrated filtrate obtained in step 5 to prepare granules, and then sterilize and package them to obtain the granule of the traditional Chinese medicine preparation of the present invention.

[0017] Preferably, the traditional Chinese medicine preparation is a drug for preventing and treating Mycoplasma synoviae in chickens, and the specific dosage is as follows:

[0018] (1) The dosage form of the traditional Chinese medicine preparation is an aqueous solution, and 100 ml is mixed with 300 catties of water for drinking;

[0019] (2) The traditional Chinese medicine preparation is a granule, and 100 g is mixed with 300 catties of water for drinking.

[0020] Preferably, the water temperature for warm-soaking the crude traditional Chinese medicine powder in step three is 70 degrees Celsius.

[0021] (III) Beneficial effects

[0022] Compared with the prior art, the present invention provides a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application, which has the following beneficial effects:

[0023] 1. The traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application are obtained by reasonably combining fourteen Chinese herbal medicines such as Eucommia ulmoides leaves, Psoralea corylifolia, Lycium chinense Mill., Bupleurum chinense DC., Paeonia lactiflora Pall., Platycodon grandiflorum (Jacq.) A. DC. according to the principle of syndrome differentiation and treatment in traditional Chinese medicine, giving full play to the effects of each medicine, and the medicines jointly coordinate to increase the medicinal effect, and have the effects of promoting blood circulation to remove stasis, strengthening tendons and relieving arthralgia, dredging meridians and dispelling cold, and removing dampness and reducing swelling.

[0024] 2. The traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application are proved by clinical trials that the traditional Chinese medicine preparation of the present invention has a definite curative effect in preventing and treating Mycoplasma synoviae in chickens. Using the traditional Chinese medicine preparation of the present invention can significantly improve the health status of chickens, increase the egg production rate, reduce the broken egg rate, and the present invention is made of natural traditional Chinese medicine, with strong pertinence, remarkable curative effect, no drug resistance, and no drug residue, which is more beneficial to human health. Specific embodiments

[0025] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative work shall fall within the protection scope of the present invention.

[0026] Example 1:

[0027] A traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application are prepared according to the following steps:

[0028] Step 1: Weigh each traditional Chinese medicine component by weight parts: 10 - 20 parts of Eucommia ulmoides leaves, 5 - 13 parts of Psoralea corylifolia, 3 - 10 parts of Cortex Lycii Radicis, 3 - 10 parts of Corydalis yanhusuo, 2 - 8 parts of Bupleurum chinense, 5 - 13 parts of Paeonia lactiflora, 3 - 10 parts of Platycodon grandiflorum, 2 - 8 parts of Curcuma aromatica, 2 - 8 parts of Glycyrrhiza uralensis, 3 - 10 parts of Ramulus Cinnamomi, 2 - 8 parts of Rhizoma Zingiberis, 5 - 12 parts of Achyranthes bidentata, 2 - 8 parts of Atractylodes lancea, 5 - 13 parts of Polyporus umbellatus;

[0029] Step 2: Wash the raw materials weighed in Step 1 with clean water, dry the washed raw materials and crush them into powders, and use a stirrer to mix various raw material powders evenly to obtain a crude traditional Chinese medicine powder;

[0030] Step 3: Put the crude traditional Chinese medicine powder obtained in Step 2 into an extraction tank, add water to carry out warm soaking on the crude traditional Chinese medicine powder at 70 °C, and the warm soaking time is 30 minutes;

[0031] Step 4: Decoct the warm-soaked crude traditional Chinese medicine powder in Step 3 three times with 10 times the amount of water, each time for 2 hours, then combine the decoctions and let it stand for 12 hours;

[0032] Step 5: Filter the decoction that has stood well in Step 4, and concentrate the filtrate to a relative density of 1.2 - 1.3 (measured at 80 °C), and cool it to room temperature for standby;

[0033] Step 6: Dissolve and mix an appropriate amount of sodium benzoate in the concentrated filtrate obtained in Step 5, fill it into containers, sterilize it, and package it to obtain the aqueous solution of the traditional Chinese medicine preparation of the present invention. The prepared traditional Chinese medicine preparation is a drug for preventing and treating Mycoplasma synoviae in chickens. The specific dosage is: 300 catties of water is mixed with every 100 ml for drinking;

[0034] Step 7: Spray-dry the concentrated filtrate obtained in Step 5 to prepare a granule, and sterilize and package it to obtain the granule of the traditional Chinese medicine preparation of the present invention.

[0035] The prepared traditional Chinese medicine preparation is a drug for preventing and treating Mycoplasma synoviae in chickens. The specific dosage is: 300 catties of water is mixed with every 100 g for drinking.

[0036] Example 2:

[0037] The difference between this example and Example 1 lies in

[0038] Raw materials (by weight parts): 14 parts of Eucommia ulmoides leaves, 8 parts of Psoralea corylifolia, 7 parts of Cortex Lycii Radicis, 7 parts of Corydalis yanhusuo, 5 parts of Bupleurum chinense, 8 parts of Paeonia lactiflora, 7 parts of Platycodon grandiflorum, 5 parts of Curcuma aromatica, 5 parts of Glycyrrhiza uralensis, 7 parts of Ramulus Cinnamomi, 5 parts of Rhizoma Zingiberis, 8 parts of Achyranthes bidentata, 5 parts of Atractylodes lancea, 8 parts of Polyporus umbellatus.

[0039] Example 3:

[0040] In a 12,000 - chicken farm in Fengqiu County, Henan Province, chickens at the age of 50 days were successively found to have symptoms such as lameness, listlessness, and decreased feed intake. One week later, more than 800 chickens in the flock were affected. The diseased chickens were emaciated, with swollen tarsal joints, toe joints, wing joints, and foot pads. Some chickens had respiratory symptoms and excreted yellow - green loose stools. Upon autopsy, yellow purulent secretions or yellow - white caseous secretions were visible at the swollen joints. The keel wings were slightly deformed, and the air sacs of some autopsy subjects were turbid, and the kidneys were slightly enlarged, showing a mottled appearance. According to the local disease prevalence, clinical symptoms, and autopsy results, it was diagnosed as Mycoplasma synoviae infection, and the diseased chickens were randomly divided into two groups for isolated feeding and treatment.

[0041] 1 Materials and Methods;

[0042] 1.1 Test drugs.

[0043] The Chinese medicine granule of the present invention, the Chinese medicine aqueous solution of the present invention;

[0044] 1.2 Test animals;

[0045] The diseased chickens were randomly divided into two groups: experimental group 1 and experimental group 2, with 400 chickens in each group.

[0046] 1.3 Test methods;

[0047] 1.3.1 The drugs were administered (mixed with water) in the feed according to the doses described in Table 1. The drugs were continuously administered for 7 days and then discontinued after 7 days.

[0048] Table 1 Experimental groups and drug administration doses

[0049]

[0050] 1.3.2 The two - group experiments were carried out under the same feeding conditions, and the chicken house environment was disinfected daily as required.

[0051] 1.3.3 Observation and measurement items: Observe the changes and health status of the chicken flock daily and record the feed intake.

[0052] Criteria for judging the treatment effect: (1) Effective: The spirit and appetite of the diseased chickens gradually recover, the diseased chickens gradually recover, and can gradually stand, and the joint swelling shows a tendency to subside; (2) Cured: The spirit and appetite of the diseased chickens return to normal, can stand, and the joint swelling significantly subsides; (3) Ineffective: After medication, the symptoms of the diseased chickens do not relieve, and even worsen or die.

[0053] 2 Results and Analysis;

[0054] 2.1 Chicken clinical manifestations.

[0055] After the end of the treatment period, the joint swelling of chickens in experimental groups 1 and 2 significantly subsided, their mental state recovered well, and their food intake and drinking water tended to return to normal. From the results in Table 2, it can be seen that the cure rates and effective numbers of experimental groups 1 and 2 both reached over 95%, effectively controlling the epidemic situation and achieving satisfactory treatment effects.

[0056] Table 2 Treatment effects of chickens in each group

[0057]

[0058] Example 4:

[0059] Laying hens at a laying hen farm in Kunming, Yunnan Province, at 180 days of age became ill, with sporadic deaths. The dead laying hens were extremely emaciated. Upon autopsy, purulent secretions were visible in the tarsal joints, the sternum was deformed, and a large amount of caseous secretions adhered. The diseased chickens showed lameness and paralysis symptoms before death; the feed intake of the large group decreased, some diseased chickens showed pale heads and inverted combs, the egg production rate decreased, and the number of broken eggs exceeded the standard; samples were taken for laboratory PCR detection, and Mycoplasma synoviae was positive.

[0060] 1 Materials and methods;

[0061] 1.1 Test drugs.

[0062] The traditional Chinese medicine granule of the present invention, the traditional Chinese medicine aqueous solution of the present invention, 20% doxycycline hydrochloride soluble powder.

[0063] 1.2 Test animals;

[0064] The chicken house and the site were thoroughly disinfected, and the diseased chickens with damaged and deformed joints were culled. The remaining 1,500 diseased chickens were selected and isolated for treatment. The diseased chickens were randomly divided into three groups, namely experimental group 1, experimental group 2, and drug control group, with 500 chickens in each group.

[0065] 1.3 Test methods;

[0066] 1.3.1 The drugs were administered (mixed with water) in the feed according to the doses described in Table 3. The drugs were continuously administered for 7 days and then discontinued after 7 days.

[0067] Table 3 Experimental groups and drug administration doses

[0068]

[0069] 1.3.2 Each grouped test was carried out under the same feeding conditions. The eggs produced by the isolated diseased chickens were counted 2 days before the test, and the eggs produced by the experimental groups were counted within half a month after the start of the test.

[0070] 1.3.3 Observation and determination items: Observe the changes and health status of the chicken flock every day, and record the feed intake, egg production, egg weight, and number of broken eggs.

[0071] Criteria for judging treatment effects:

[0072] (1) Effective: The spirit and appetite of the diseased chickens gradually recover, the diseased chickens gradually recover, can gradually stand up, the joint swelling shows a tendency to subside, the egg production rate has a certain increase, and the number of inferior eggs decreases; (2) Cured: The spirit and appetite of the diseased chickens return to normal, can stand up, the joint swelling significantly subsides, the egg production rate has a certain increase, and the number of broken eggs decreases; (3) Ineffective: After medication, the symptoms of the diseased chickens do not relieve, even worsen or die, the egg production rate continues to decline, and the number of broken eggs increases.

[0073] 2 Results and analysis;

[0074] 2.1 Clinical manifestations of laying hens.

[0075] At the end of the treatment period, the laying hens in experimental groups 1 and 2 and the drug control group all had significantly subsided joint swelling, better mental recovery, normal feeding and drinking, increased egg production rate, and decreased number of broken eggs. As can be seen from the results in Table 4, the cure rate and effective number of experimental groups 1 and 2 are both higher than those of the drug control group, and the ineffective number is also much lower than that of the drug control group.

[0076] Table 4 Treatment effects of laying hens in each group

[0077] Group Quantity (pcs) Cured (pcs) Effective (pcs) Ineffective (pcs) Cure rate (%) Experimental Group 1 500 478 482 18 95.6 Experimental Group 2 500 476 483 17 95.2 Control Drug Group 500 461 464 36 92.2

[0078] 2.2 Egg production of laying hens;

[0079] As can be seen from the results in Table 5, comparing the egg production of laying hens 2 days before the start of the treatment period and on the 15th day of treatment, first of all, the egg production of experimental groups 1 and 2 and the control drug group has a relatively obvious increase, and the egg production rates have increased by 21.0%, 17.8%, and 16.0% respectively; compared with the drug control group, experimental groups 1 and 2 show better performance. The broken egg rates of experimental groups 1 and 2 also remain below 1%. The above results are consistent with the clinical manifestations of laying hens, indicating that the traditional Chinese medicine preparation of the present invention has more advantages in treating Mycoplasma synoviae disease in laying hens, the curative effect is more obvious, is expected to replace traditional veterinary drugs, avoid the use of antibiotics, and the dosage form of the traditional Chinese medicine preparation of the present invention has no influence on the drug effect. The test results show that both the aqueous solution and the granule show the prevention and treatment effects of Mycoplasma synoviae disease in laying hens.

[0080] Table 5 Egg production of laying hens

[0081]

[0082]

[0083] In the case implementation, the pharmacological effects of each traditional Chinese medicine component in the traditional Chinese medicine preparation are as follows:

[0084] Eucommia ulmoides Oliv. leaves: sweet in taste, warm in nature, belonging to the liver and kidney meridians, with the functions of tonifying the liver and kidney, strengthening tendons and bones, and preventing miscarriage, mainly treating kidney deficiency low back pain, weakness of the waist and limbs, rheumatic arthralgia, and threatened abortion.

[0085] Psoralea corylifolia: Pungent and bitter in taste, warm in nature. It acts on the kidney and spleen meridians. It has the functions of warming the kidney and strengthening yang, absorbing qi to relieve asthma, and warming the spleen to stop diarrhea. It is mainly used to treat impotence, spermatorrhea, frequent urination, cold pain in the waist and hips, kidney deficiency asthma, spleen-kidney yang deficiency, and diarrhea.

[0086] Lycium chinense Mill. Root-bark: Sweet in taste, cold in nature. It acts on the lung, liver, and kidney meridians. It has the functions of cooling blood to reduce fever and clearing the lung to purge fire. It is mainly used to treat yin deficiency with blood heat and cough and asthma due to lung heat.

[0087] Corydalis yanhusuo: Pungent and bitter in taste, warm in nature. It acts on the liver and spleen meridians. It has the effects of promoting blood circulation to remove stasis and regulating qi to relieve pain. It is mainly used to treat qi stagnation and blood stasis, traumatic injury, postpartum stasis obstruction, and rheumatic arthralgia.

[0088] Bupleurum chinense DC.: Pungent and bitter in taste, slightly cold in nature. It acts on the liver, gallbladder, and lung meridians. It has the effects of inducing sweating to relieve exterior syndrome and interior syndrome, lifting yang qi, and soothing the liver and relieving depression. It is used for common cold with fever, alternating chills and fever, chronic diarrhea due to spleen deficiency, uterine prolapse, and rectal prolapse.

[0089] Paeonia lactiflora Pall.: Bitter and sour in taste, slightly cold in nature. It acts on the liver and spleen meridians. It has the effects of soothing the liver to relieve pain and nourishing blood to astringe yin. It is used for insufficiency of liver yin, deficiency heat, diarrhea and abdominal pain, and convulsion of the four limbs.

[0090] Platycodon grandiflorus (Jacq.) A. DC.: Bitter and pungent in taste, neutral in nature. It acts on the lung meridian. It has the effects of dispersing the lung qi, resolving phlegm, alleviating sore throat, and discharging pus. It is used for profuse phlegm and cough, sore throat, and lung abscess.

[0091] Curcuma aromatica Salisb.: Pungent and bitter in taste, cold in nature. It acts on the liver, heart, and lung meridians. It has the effects of regulating qi to relieve depression, cooling blood to promote blood circulation, and promoting bile secretion to remove jaundice. It is used for chest and abdominal distension, diarrhea, coma due to febrile disease, and damp-heat jaundice.

[0092] Glycyrrhiza uralensis Fisch.: Sweet in taste, neutral in nature. It acts on the heart, lung, spleen, and stomach meridians. It has the effects of invigorating the spleen and replenishing qi, resolving phlegm and relieving cough, coordinating the actions of various drugs, and detoxifying. It is used for weakness of the spleen and stomach, listlessness and fatigue, cough and asthma, sore throat, poisoning, and sores and ulcers.

[0093] Cinnamomum cassia Presl: Pungent and sweet in taste, warm in nature. It acts on the heart, lung, and bladder meridians. It has the effects of inducing sweating to relieve the exterior syndrome and warming the channels to promote yang qi. It is used for wind-cold exterior syndrome, arthralgia, and retention of water and dampness.

[0094] Zingiber officinale Rosc.: Pungent in taste, hot in nature. It acts on the spleen, stomach, kidney, heart, and lung meridians. It has the effects of warming the middle-jiao to dispel cold, restoring yang and promoting blood circulation, and drying dampness and resolving phlegm. It is used for coldness in the stomach with reduced appetite, diarrhea due to cold intestine, cold pain, cold limbs, wind-cold-damp arthralgia, and cough with fluid retention.

[0095] Achyranthes bidentata Blume: Bitter, sweet, and sour in taste, neutral in nature. It acts on the liver and kidney meridians. It has the effects of tonifying the liver and kidney, strengthening tendons and bones, removing blood stasis and dredging meridians, and guiding blood downward. It is used for pain in the waist and hips, traumatic injury, postpartum blood stasis, and retention of the fetal membranes.

[0096] Atractylodes lancea: Pungent, bitter, and warm in nature, it pertains to the spleen, stomach, and liver meridians, and has the effects of drying dampness and strengthening the spleen, dispelling wind and cold, and improving eyesight; it is used for diarrhea, edema, wind-cold-damp arthralgia, wind-cold common cold, and night blindness.

[0097] Polyporus umbellatus: Pungent and salty in taste, warm in nature; slightly poisonous, it pertains to the lung and large intestine meridians, and has the effects of eliminating phlegm and opening orifices, dissipating binds and relieving swelling; it is used for stroke, epilepsy, phlegm dyspnea, and orifice obstruction; externally, it is used for treating carbuncles and sores.

[0098] The beneficial effects of the present invention are as follows: The traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens and its application are obtained by rationally combining fourteen kinds of Chinese herbal medicines such as Eucommia ulmoides leaves, Psoralea corylifolia, Lycium chinense Miller, Bupleurum chinense, Paeonia lactiflora, and Platycodon grandiflorum according to the principle of syndrome differentiation and treatment in traditional Chinese medicine, giving full play to the effects of each medicine, and the various medicines jointly coordinate to enhance the medicinal effects, and have the effects of promoting blood circulation to remove stasis, strengthening tendons and relieving arthralgia, dredging meridians and dispelling cold, and removing dampness and relieving swelling.

[0099] Moreover, through clinical trials, it is proved that the traditional Chinese medicine preparation of the present invention has definite curative effects in preventing and treating Mycoplasma synoviae in chickens. Using the traditional Chinese medicine preparation of the present invention can significantly improve the health status of chickens, increase the egg production rate, and reduce the cracked egg rate. The present invention is made of natural traditional Chinese medicines, has strong pertinence, remarkable curative effects, no drug resistance, and no drug residues, is more conducive to human food safety, and is beneficial to human health. Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirits of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens, characterized in that, It is composed of raw materials with the following weight ratio: 10 - 20 parts of Eucommia ulmoides leaves, 5 - 13 parts of Psoralea corylifolia, 3 - 10 parts of Cortex Lycii, 3 - 10 parts of Corydalis yanhusuo, 2 - 8 parts of Bupleurum chinense, 5 - 13 parts of Paeonia lactiflora, 3 - 10 parts of Platycodon grandiflorum, 2 - 8 parts of Curcuma aromatica, 2 - 8 parts of Glycyrrhiza uralensis, 3 - 10 parts of Ramulus Cinnamomi, 2 - 8 parts of Rhizoma Zingiberis, 5 - 12 parts of Achyranthes bidentata, 2 - 8 parts of Atractylodes lancea, 5 - 13 parts of Polyporus umbellatus.

2. The traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens according to claim 1, wherein the traditional Chinese medicine components in parts by weight are: 14 parts of Eucommia ulmoides leaves, 8 parts of Psoralea corylifolia, 7 parts of Cortex Lycii, 7 parts of Corydalis yanhusuo, 5 parts of Bupleurum chinense, 8 parts of Paeonia lactiflora, 7 parts of Platycodon grandiflorum, 5 parts of Curcuma aromatica, 5 parts of Glycyrrhiza uralensis, 7 parts of Ramulus Cinnamomi, 5 parts of Rhizoma Zingiberis, 8 parts of Achyranthes bidentata, 5 parts of Atractylodes lancea, 8 parts of Polyporus umbellatus.

3. The traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae disease in chickens according to claim 1, wherein, The dosage form of the traditional Chinese medicine preparation is an aqueous solution or granules.

4. A preparation method of a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae in chickens, characterized in that, It includes the following steps: Step 1: Weigh each traditional Chinese medicine component according to the weight ratio: 14 parts of Eucommia ulmoides leaves, 8 parts of Psoralea corylifolia, 7 parts of Cortex Lycii, 7 parts of Corydalis yanhusuo, 5 parts of Bupleurum chinense, 8 parts of Paeonia lactiflora, 7 parts of Platycodon grandiflorum, 5 parts of Curcuma aromatica, 5 parts of Glycyrrhiza uralensis, 7 parts of Ramulus Cinnamomi, 5 parts of Rhizoma Zingiberis, 8 parts of Achyranthes bidentata, 5 parts of Atractylodes lancea, 8 parts of Polyporus umbellatus; Step 2: Wash the raw materials weighed in Step 1 with clean water, dry the washed raw materials and crush them into powders, and use a stirrer to mix various raw material powders evenly to obtain crude traditional Chinese medicine powder; Step 3: Put the crude traditional Chinese medicine powder obtained in Step 2 into an extraction tank, add water to conduct warm soaking on the crude traditional Chinese medicine powder, and the warm soaking time is 30 minutes; Step 4: Decoct the warm - soaked crude traditional Chinese medicine powder in Step 3 three times with water, each time for 2 hours, then combine the decoctions and let it stand for 12 hours; Step 5: Filter the medicinal liquid that has stood well in Step 4, and concentrate the filtrate to a relative density of 1.2 - 1.3 (measured at 80°C), and cool it to room temperature for standby; Step 6: Add an appropriate amount of sodium benzoate to the concentrated filtrate obtained in Step 5, dissolve and mix it evenly, and then fill it to obtain the aqueous solution of the traditional Chinese medicine preparation of the present invention; Step 7: Spray - dry the concentrated filtrate obtained in Step 5 to prepare granules, and sterilize and package them to obtain the granule of the traditional Chinese medicine preparation of the present invention.

5. The preparation method of a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae disease in chickens according to claim 4, characterized in that, The traditional Chinese medicine preparation is a drug for preventing and treating Mycoplasma synoviae in chickens, and the specific dosage is: (1) When the dosage form of the traditional Chinese medicine preparation is an aqueous solution, 100 ml of it is mixed with 300 catties of water for drinking; (2) When the traditional Chinese medicine preparation is granules, 100 g of it is mixed with 300 catties of water for drinking.

6. The preparation method of a traditional Chinese medicine preparation for preventing and treating Mycoplasma synoviae disease in chickens according to claim 4, characterized in that, The water temperature for warm - soaking the crude traditional Chinese medicine powder in Step 3 is 70 degrees Celsius.

Images