Axial rotation locking sterile connection device, docking station, system and connection method

Abstract

The present invention discloses an axial rotation locking aseptic connection device, a docking device, a system and a connection method, which relate to the technical field of aseptic connectors. The technical scheme thereof mainly includes a connecting member, an axial rotation buckle, a sterile barrier membrane and a sealing ring; the connecting member includes a main body, a tube head, a connecting portion and a limiting portion, and the sealing ring is connected to the tube head in the main body; the sterile barrier membrane is fitted with the sealing ring; the limiting portion is connected to the main body through the connecting portion; the axial rotation buckle and the limiting portion are respectively on both sides of the tube head; the axial rotation buckle is rotatably connected to the main body; the axial rotation buckle is provided with a limiting groove, the groove wall of the limiting groove is used to interfere with the limiting portion to radially position the sealing ring and apply axial extrusion force to the sealing ring; the limiting portion is provided with a fastening member, and a back-stop groove is provided on the inner groove wall of the limiting groove, and the back-stop groove is used to engage with the fastening member. The present invention can complete the connection of two aseptic connection devices only through the relative rotation of the limiting portion and the axial rotation buckle, and the operation is simple and no strong pressing is required.

Description

Technical Field

[0001] The present invention relates to the technical field of sterile connectors, and more particularly to an axially rotating locking sterile connection device. Background Art

[0002] In the fields of biology, medicine, and other technologies, it is often necessary to connect different containers together under sterile conditions to construct a sterile fluid pathway. In the prior art, sterile connectors are often used to connect two containers.

[0003] For example, Chinese patent CN216201461U discloses a sterile coupling connector, which includes a connector body and an isolation membrane; a limiting groove is provided at one end of the connector body, and the axis of the limiting groove is on the same straight line as the axis of the connector body; a connecting piece is installed inside the limiting groove, and the connection between the connecting piece and the limiting groove is a snap-fit ​​connection; a dustproof protective cover is provided on the connector body, and two snap-fit ​​pieces of unequal lengths are provided at both ends of the dustproof protective cover; the snap-fit ​​pieces are respectively snap-fitted with the card blocks, and the card blocks are respectively provided on the outer surface of the connector body; the isolation membrane is covered on the connecting piece and welded to the surface of the connector body, and the isolation membrane is a stacked structure with one end welded to the upper surface of the dustproof protective cover.

[0004] In this patent, the two sterile coupling connectors are fastened together using a snap-fit ​​structure. After fastening, the isolation membranes on the two sterile coupling connectors are pulled apart to open the sterile passage. To ensure a tight seal between the two sterile coupling connectors after the isolation membranes are removed, the snap-fit ​​structure of the two sterile coupling connectors is typically an interference fit. This makes fastening the two sterile coupling connectors difficult, and sometimes even requires the use of auxiliary tools or equipment to complete the fastening of the two sterile coupling connectors.

[0005] Based on the above reasons, the present invention hopes to further optimize the structure of the sterile connector and provide a sterile connector with lower connection difficulty. Summary of the Invention

[0006] In response to the shortcomings of the existing technology, the purpose of the present invention is to provide an axially rotating locking sterile connection device, which can complete the connection of two axially rotating locking sterile connection devices through the relative rotation of the limiting part and the axial rotating buckle, with the help of the resistance force between the two. It is simple to operate and does not require the use of auxiliary tools or equipment to press hard.

[0007] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: an axially rotating locking aseptic connection device, comprising a connecting member, an axially rotating buckle, a sterile barrier membrane and a sealing ring; the connecting member comprises a main body and a tube head, the tube head is arranged on the main body, the sealing ring is fixed in the main body and communicated with the tube head; the sterile barrier membrane is fixed on the connecting member and fits on the side of the sealing ring away from the tube head; the connecting member also includes a connecting portion and a limiting portion, the limiting portion is connected to the main body through the connecting portion; the axially rotating buckle and the limiting portion are symmetrically arranged on both sides of the tube head axis respectively; the axially rotating buckle is rotatably connected to the main body, and the rotation axis of the axially rotating buckle is perpendicular to the tube head axis; a limiting groove is provided in the axially rotating buckle, the groove wall of the limiting groove is used to interfere with the limiting portion to radially position the sealing ring and apply axial extrusion force to the sealing ring; a fastening piece is provided on the limiting portion, and a retreat groove is provided on the inner groove wall of the limiting groove, and the retreat groove is used to engage with the fastening piece.

[0008] The present invention is further configured such that: the limiting portion is fan-shaped.

[0009] The present invention is further configured such that: a slope for guiding the fastening member from outside the limiting groove into the anti-retraction groove is further provided on the groove wall of the limiting groove.

[0010] The present invention is further configured as follows: an initial groove is provided on the groove wall of the limiting groove, and the fastening member can be rotated from the initial groove to the outside of the limiting groove.

[0011] The present invention is further configured as follows: a rotation direction indication mark is provided on the axial rotation buckle, which is used to indicate the rotation direction of the axial rotation buckle when the fastening member moves from the initial groove to the stop groove.

[0012] The present invention is further configured as follows: the axial rotating buckle is provided with a side parallel to the radial direction of its rotating axis, and a locking indicator strip is provided on the main body; when the locking indicator strip is aligned with the side, the fastener is engaged with the wall of the anti-retraction groove.

[0013] The present invention is further configured such that: a handle is provided on the axial rotating buckle.

[0014] The present invention further comprises a pin for rotatably connecting the axial rotating buckle to the main body, the pin having a stopper at one end and circumferential teeth at the other end. The main body is provided with a pin hole. After the pin passes through the axial rotating buckle, the end provided with the circumferential teeth is inserted into the pin hole and forms an interference fit therewith.

[0015] The present invention is further configured as follows: a positioning protrusion and a positioning groove for accommodating the positioning protrusion are provided on the main body, the positioning protrusion and the positioning groove correspond to each other one by one, and the corresponding positioning protrusions and positioning grooves are symmetrically arranged on both sides of the axis of the tube head.

[0016] The present invention is further configured to include a pull ring fixedly connected to the sterile barrier membrane.

[0017] The present invention is further configured as follows: the pull ring is provided with a male buckle and a stop for engaging with the male buckle.

[0018] The present invention is further configured as follows: an installation indicator strip is provided on the main body, and the installation indicator strip is provided on any side surface of the main body parallel to the axis of the tube head.

[0019] The present invention is further configured as follows: a first annular groove is provided on the inner side of the sealing ring, a second annular groove is provided on the outer side of the sealing ring, and the groove walls of the first annular groove and the second annular groove are both arc-shaped.

[0020] The present invention is further configured such that: the cross-sectional area of ​​the first annular groove is greater than the cross-sectional area of ​​the second annular groove.

[0021] The present invention is further configured to further include a protective cover, which is located on a side of the sterile barrier membrane facing away from the connecting member and is detachably fixedly connected to the connecting member.

[0022] The present invention is further configured as follows: the protective cover includes a cover body and a gripping portion that are snap-connected to the connecting member; and anti-slip grooves are provided on a side of the gripping portion close to the connecting member.

[0023] The present invention also provides a sterile docking device, including a first sterile connecting component and a second sterile connecting component. Fluid channels are arranged inside the first sterile connecting component and the second sterile connecting component. After the first sterile connecting component and the second sterile connecting component are docked, a sterile circulation channel for fluid flow is formed. The first sterile connecting component and the second sterile connecting component both adopt the above-mentioned axial rotation locking sterile connection device.

[0024] The present invention also provides a sterile connection system, comprising a first container, a second container, and a sterile docking device connecting the first container and the second container, wherein the sterile docking device adopts the above-mentioned sterile docking device.

[0025] The present invention also provides a sterile connection method, which is applied to the above-mentioned axial rotation locking sterile connection device, comprising the following steps:

[0026] S1. Connect two axially rotating and locking aseptic connection devices with the same structure so that the two sterile barrier membranes are in contact with each other with the sides facing away from their corresponding sealing rings, and the two sealing rings are aligned.

[0027] S2. Rotate the two axially rotating buckles so that the fastening piece of one axially rotating locking aseptic connection device is engaged with the withdrawal preventing groove of the other axially rotating locking aseptic connection device.

[0028] S3. Pull out the two sterile barrier membranes to form a sterile fluid pathway.

[0029] In summary, the present invention has the following beneficial effects compared to the prior art:

[0030] 1. The present invention does not distinguish between male and female. When users construct a sterile fluid channel, they do not need to waste time and experience to distinguish between male and female, thereby improving the efficiency of sterile connection.

[0031] 2. The present invention can complete the connection of the two axially rotating and locking sterile connecting devices only through the relative rotation of the limiting part and the axial rotating buckle, with the help of the resistance force between the two. The operation is simple and there is no need to use auxiliary tools or equipment to press hard. The friction contact and snap connection between the two further improve the connection reliability of the two axially rotating and locking sterile connecting devices.

[0032] 3. The present invention adds a snap-connectable pull ring to the sterile barrier membrane, and the snap connection of the pull ring enables the simultaneous removal of two isolation films.

[0033] 4. In the present invention, a first annular groove and a second annular groove are provided inside and outside the sealing ring, thereby reducing the variation of the CV value inside the sealing ring. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 An exploded view of the axial rotation locking sterile connection device;

[0035] Figure 2 It is an overall schematic diagram of the axial rotation locking sterile connection device;

[0036] Figure 3 is a schematic diagram of a protective cover;

[0037] Figure 4 A schematic diagram showing a fastening member;

[0038] Figure 5 A schematic diagram showing the locking indicator strip;

[0039] Figure 6 A schematic diagram showing the rotation direction indicator;

[0040] Figure 7 A schematic diagram showing the limit slot;

[0041] Figure 8 It is a schematic diagram of the pin shaft;

[0042] Figure 9 is a cross-sectional view of the sealing ring;

[0043] Figure 10 Schematic diagram of the two-axis rotation locking sterile connection device during S1;

[0044] Figure 11 Schematic diagram of the two-axis rotation locking sterile connection device during S2.

[0045] In the figure: 1. Connecting member; 11. Main body; 111. Locking indicator strip; 112. Pin hole; 113. Installation indicator strip; 12. Pipe head; 13. Limiting part; 131. Fastening part; 14. Connecting part; 2. Axial rotation buckle; 21. Limiting groove; 22. Anti-retraction groove; 23. Initial groove; 24. Inclined surface; 25. Rotation direction indicator mark; 26. Observation hole; 27. Handle; 3. Sterile barrier membrane; 4. Sealing ring; 41. First annular groove; 42. Second annular groove; 5. Protective cover; 51. Cover body; 52. Grip; 521. Anti-slip groove; 6. Pin shaft; 61. Stopper; 62. Circumferential teeth; 71. Positioning protrusion; 72. Positioning groove; 8. Pull ring; 81. Male buckle; 82. Stopper; 91. Slot; 92. Connecting part. DETAILED DESCRIPTION

[0046] The technical solution of the present invention will be clearly described below in conjunction with the accompanying drawings. Obviously, the described embodiments are not all embodiments of the present invention. All other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the invention.

[0047] It should be noted that the terms "center", "up", "down", "horizontal", "left", "right", "front", "back", "lateral", "longitudinal", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0048] Example

[0049] like Figure 1-9 As shown in the figure, in a preferred embodiment of the present invention, an axial rotation locking aseptic connection device includes a connecting component 1, an axial rotation buckle 2, a sterile barrier membrane 3 and a sealing ring 4.

[0050] The connecting member 1 includes a main body 11, a tube head 12, a connecting portion 14 and a limiting portion 13. The tube head 12 is arranged on the main body 11. The sealing ring 4 is fixed in the main body 11 and is connected to the tube head 12. The end of the sealing ring 4 facing away from the tube head 12 protrudes from the side of the main body 11 facing away from the tube head 12; the sterile barrier membrane 3 is fixed on the connecting member 1 and fits with the side of the sealing ring 4 facing away from the tube head 12. The limiting portion 13 is connected to the main body 11 through the connecting portion 14; the axial rotating buckle 2 and the limiting portion 13 are symmetrically arranged on both sides of the axis of the tube head 12; the axial rotating buckle 2 is rotatably connected to the main body 11, and the rotation axis of the axial rotating buckle 2 is perpendicular to the axis of the tube head 12; a limiting groove 21 is provided in the axial rotating buckle 2, and the groove wall of the limiting groove 21 is used to contact with the limiting portion 13 to perform radial positioning of the sealing ring 4 and apply axial extrusion force to the sealing ring 4; a fastening part 131 is provided on the limiting portion 13, and a retreat groove 22 is provided on the inner groove wall of the limiting groove 21, and the retreat groove 22 is used to engage with the fastening part 131 to lock the limiting portion 13 in the limiting groove 21.

[0051] Specifically, in this embodiment, the pipe head 12 is a pagoda-shaped pipe head, which has a strong connection strength with other fluid channels.

[0052] Specifically, in this embodiment, the limiting portion 13 and the axial rotation buckle 2 are distributed at 180° around the axis of the tube head 12 .

[0053] Specifically, the limiting portion 13 is fan-shaped, with at least one of its plane proximal to the main body 11 and its plane facing away from the main body 11 being configured to engage the wall of the limiting groove 21, thereby achieving radial positioning and increasing the frictional contact area between the limiting portion 13 and the wall of the limiting groove 21, thereby enhancing the locking effect between the limiting portion 13 and the axially rotating buckle 2. In this embodiment, the arcuate edges of the limiting portion 13 are chamfered at both ends to facilitate entry of the limiting portion 13 into the limiting groove 21. In this embodiment, the limiting portion 13 is fan-shaped with a central angle of 180 degrees.

[0054] Specifically, this embodiment further includes a protective cover 5, which is located on the side of the sterile barrier membrane 3 facing away from the connecting member 1 and is detachably fixedly connected to the connecting member 1 to protect the sterile barrier membrane 3. When the two-axis rotation locking sterile connection device needs to be connected, the protective cover 5 can be detached from the connecting member 1.

[0055] The protective cover 5 in this embodiment includes a cover body 51 that snaps into contact with the connecting member 1 and a grip portion 52. In this embodiment, both sides of the main body 11 and the cover body 51 are provided with a snap-fitting slot 91 and a snap-fitting member 92. The main body 11 and the cover body 51 are connected through the snap-fitting engagement of the snap-fitting slots 91 and the snap-fitting member 92. In this embodiment, there are four snap-fitting slots 91 and four snap-fitting members 92. The grip portion 52 is provided with anti-slip grooves 521 on the side closest to the connecting member 1 to increase friction between the user's hand and the protective cover 5, making it easier for the user to remove the protective cover 5 from the connecting member 1.

[0056] Specifically, an initial groove 23 is further provided on the wall of the limiting groove 21, and the fastener 131 can be rotated from the initial groove 23 to the outside of the limiting groove 21. The initial groove 23 can protect the fastener when the axial rotation locking sterile connection device is not in use.

[0057] Specifically, a slope 24 is further provided on the groove wall of the limiting groove 21 , and the slope 24 is used to guide the fastening member 131 to enter the anti-retraction groove 22 from outside the limiting groove 21 .

[0058] Specifically, the axially rotatable buckle 2 is provided with a rotation direction indicator mark 25, which is used to indicate the rotation direction of the axially rotatable buckle 2 when the fastening member 131 moves from the initial groove 23 to the retaining groove 22. The rotation direction indicator mark 25 helps the user determine the rotation direction of the axially rotatable buckle 2, prevents the fastening member 131 from colliding with the groove wall of the initial groove 23, and protects the fastening member 131.

[0059] Specifically, the axially rotating buckle 2 is provided with a side edge parallel to the radial direction of its rotation axis, and the main body 11 is provided with a locking indicator strip 111. When the locking indicator strip 111 is aligned with the side edge, the fastening member 131 engages with the wall of the backstop groove 22. The locking indicator strip 111 helps the user determine whether the axially rotating buckle 2 is fully rotated, preventing the axially rotating buckle 2 from being rotated too far and preventing the fastening member 131 from being damaged by the wall of the backstop groove 22.

[0060] Specifically, a plurality of observation holes 26 are provided on the side of the axial rotating buckle 2 facing away from the main body 11 or on the arc surface coaxial with the rotation axis of the axial rotating buckle 2. All observation holes 26 are arranged around the rotation axis of the axial rotating buckle 2, so that the user can observe the movement process of the limiting portion 13 in the limiting groove 21 through the observation holes 26.

[0061] Specifically, a handle 27 is provided on the axial rotating buckle 2 to facilitate the user to rotate the axial rotating buckle 2 .

[0062] Specifically, this embodiment also includes a pin 6, which is used to achieve the rotational connection between the axial rotating buckle 2 and the main body 11. The pin 6 is provided with a stopper 61 at one end and circumferential teeth 62 at the other end. A pin hole 112 is provided in the main body 11. After the pin 6 passes through the axial rotating buckle 2, the stopper 61 is located on the side of the axial rotating buckle 2 facing away from the main body 11, while the end provided with the circumferential teeth 62 is inserted into the pin hole 112 and forms an interference fit therewith, ensuring a reliable connection between the pin 6 and the main body 11.

[0063] Specifically, the main body 11 is provided with positioning protrusions 71 and positioning grooves 72 for accommodating the positioning protrusions 71. The positioning protrusions 71 and positioning grooves 72 correspond one to one, and the corresponding positioning protrusions 71 and positioning grooves 72 are symmetrically arranged on both sides of the axis of the tube head 12. When all the positioning protrusions 71 of one axial rotation locking sterile connection device are fully inserted into all the positioning grooves 72 of the other axial rotation locking sterile connection device, the sealing rings 4 of the two axial rotation locking sterile connection devices are aligned. In this embodiment, two positioning protrusions 71 and two positioning grooves 72 are each provided, and all positioning protrusions 71 and positioning grooves 72 are arranged at intervals and evenly distributed around the axis of the tube head 12.

[0064] Specifically, this embodiment further includes a pull ring 8 , which is fixedly connected to the sterile barrier membrane 3 , so that the user can remove the sterile barrier membrane 3 from the connecting component 1 .

[0065] Specifically, the pull ring 8 is provided with a male buckle 81 and a stopper 82 for engaging with the male buckle 81 . The pull rings 8 of the two axially rotating and locking aseptic connection devices can be fixed together by the cooperation between the male buckle 81 and the stopper 82 .

[0066] Specifically, the main body 11 is provided with an installation indicator strip 113, which is provided on any side surface of the main body 11 parallel to the axis of the tube head 12. When the installation indicator strips 113 of the two axial rotation locking aseptic connection devices are aligned, the pull rings 8 of the two axial rotation locking aseptic connection devices can be aligned vertically, thereby facilitating the mating of the male buckle 81 and the stopper 82.

[0067] A first annular groove 41 is provided inside the sealing ring 4. The groove wall of the first annular groove 41 is arc-shaped in cross section. When the sealing ring 4 is axially squeezed, the first annular groove 41 can limit the internal expansion of the sealing ring 4, thereby reducing the change in the fluid coefficient (CV) within the sealing ring 4.

[0068] Specifically, a second annular groove 42 is provided on the outside of the sealing ring 4. The groove wall of the second annular groove 42 is arc-shaped in cross section, and the centerline of the arc-shaped groove wall of the first annular groove 41 is coplanar with the centerline of the arc-shaped groove wall of the second annular groove 42. The first annular groove 41 and the second annular groove 42 cooperate with each other to limit the expansion of the sealing ring 4 on both the inside and outside, further reducing the variation of the CV value within the sealing ring 4.

[0069] Specifically, the groove depth of the first annular groove 41 is greater than or equal to the groove depth of the second annular groove 42, where the groove depth refers to the depth of the groove perpendicular to the axial direction of the tube head 12. At the same time, the groove wall radius of the first annular groove 41 is greater than the groove wall radius of the second annular groove 42 to ensure that the cross-sectional area of ​​the second annular groove 42 is smaller than the cross-sectional area of ​​the first annular groove 41, so that when the sealing ring 4 is subjected to axial pressure, the expansion trends on the inner and outer sides of the sealing ring 4 are relatively balanced, further reducing the change in the CV value in the sealing ring 4.

[0070] This embodiment also provides a sterile docking device, including a first sterile connecting component 1 and a second sterile connecting component 1. Fluid channels are provided inside the first sterile connecting component 1 and the second sterile connecting component 1. After the first sterile connecting component 1 and the second sterile connecting component 1 are docked, a sterile circulation channel for fluid flow is formed. The first sterile connecting component 1 and the second sterile connecting component 1 both adopt the above-mentioned axial rotation locking sterile connection device.

[0071] like Figure 10-11 As shown, this embodiment further provides a sterile connection system, including a first container, a second container, and a sterile docking device connecting the first container and the second container, wherein the sterile docking device adopts the above-mentioned sterile docking device.

[0072] This embodiment also provides a sterile connection method, which is applied to the above-mentioned axial rotation locking sterile connection device, including the following steps:

[0073] S1. Attach two identical axially rotating, locking sterile connection devices so that the sides of the two sterile barrier membranes 3 facing away from their corresponding sealing rings 4 are in contact, and the two sealing rings 4 are aligned. Specifically, provide two identical axially rotating, locking sterile connection devices, remove their protective covers 5, confirm the sterility of the sides of the two sterile barrier membranes 3 proximal to the connecting member 1, and connect the two pipe heads 12 to the containers or pipes to be sterilely connected.

[0074] S2. Rotate the two axially rotating buckles 2 so that the fastening piece 131 of one axially rotating locking sterile connection device is engaged with the retaining groove 22 of the other axially rotating locking sterile connection device, thereby achieving radial positioning of the two sealing rings 4 and applying axial extrusion force to the two sealing rings 4.

[0075] S3, extracting the two sterile barrier membranes 3 to form a sterile fluid passage. When the two sterile barrier membranes 3 are extracted, the two pull rings 8 can be connected together by the cooperation of the male buckle 81 and the stopper 82, so that the two sterile barrier membranes 3 can be removed at the same time.

[0076] In summary, this embodiment can complete the connection of the two axially rotating locking sterile connection devices only through the relative rotation of the limiting portion 13 and the axial rotating buckle 2, with the help of the resistance force between the two. The operation is simple, and there is no need to use auxiliary tools or equipment to press vigorously. The friction contact and snap connection between the two further improve the connection reliability of the two axially rotating locking sterile connection devices. Secondly, this embodiment is a non-male and female design, which can improve the efficiency of sterile connection. In addition, this embodiment also adds a snap-connected pull ring 8 to the sterile barrier membrane 3. The snap connection of the pull ring 8 can realize the simultaneous removal of the two sterile barrier membranes 3. Finally, this embodiment also optimizes the structure of the sealing ring 4, and reduces the variation of the CV value in the sealing ring 4 through the design of the groove.

[0077] The foregoing description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art will readily appreciate that various modifications and variations of the present invention are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention are intended to be within the scope of protection of the present invention.

Claims

1. An axial rotation locking aseptic connection device, characterized in that: The invention comprises a connecting member (1), an axially rotating buckle (2), a sterile barrier membrane (3) and a sealing ring (4); the connecting member (1) comprises a main body (11) and a tube head (12), the tube head (12) is arranged on the main body (11), the sealing ring (4) is fixed in the main body (11) and communicates with the tube head (12); the sterile barrier membrane (3) is fixed on the connecting member (1) and fits with the side of the sealing ring (4) away from the tube head (12); the connecting member (1) also comprises a connecting portion (14) and a limiting portion (13), the limiting portion (13) is connected to the main body (11) through the connecting portion (14); the axially rotating buckle (2) and The limiting parts (13) are symmetrically arranged on both sides of the axis of the tube head (12); the axial rotating buckle (2) is rotatably connected to the main body (11), and the rotation axis of the axial rotating buckle (2) is perpendicular to the axis of the tube head (12); a limiting groove (21) is provided in the axial rotating buckle (2), and the groove wall of the limiting groove (21) is used to abut against the limiting part (13) to radially position the sealing ring (4) and apply axial extrusion force to the sealing ring (4); a fastening piece (131) is provided on the limiting part (13), and a retreat-stopping groove (22) is provided on the inner groove wall of the limiting groove (21), and the retreat-stopping groove (22) is used to engage with the fastening piece (131); The limiting portion (13) is fan-shaped; The groove wall of the limiting groove (21) is also provided with an inclined surface (24) for guiding the fastening member (131) to enter the anti-retraction groove (22) from outside the limiting groove (21); An initial groove (23) is provided on the groove wall of the limiting groove (21), and the fastening member (131) can be rotated from the initial groove (23) to the outside of the limiting groove (21).

2. The axial rotation locking aseptic connection device according to claim 1, characterized in that: The axial rotating buckle (2) is provided with a rotation direction indicating mark (25) for indicating the rotation direction of the axial rotating buckle (2) when the fastening member (131) moves from the initial groove (23) to the stop groove (22).

3. The axial rotation locking aseptic connection device according to claim 2, characterized in that: The axial rotating buckle (2) is provided with a side parallel to the radial direction of its rotating axis, and the main body (11) is provided with a locking indicator strip (111); when the locking indicator strip (111) is aligned with the side, the fastening member (131) is engaged with the wall of the backstop groove (22).

4. The axial rotation locking aseptic connection device according to claim 1, characterized in that: A handle (27) is provided on the axial rotating buckle (2).

5. The axial rotation locking aseptic connection device according to claim 1, characterized in that: The invention also includes a pin shaft (6) for rotatably connecting the axial rotating buckle (2) and the main body (11), wherein a stopper (61) is provided at one end of the pin shaft (6) and a circumferential tooth (62) is provided at the other end; a pin hole (112) is provided on the main body (11); after the pin shaft (6) passes through the axial rotating buckle (2), the end thereof provided with the circumferential tooth (62) is inserted into the pin hole (112) and is interference-fitted with the pin hole (112).

6. An axial rotation locking aseptic connection device according to any one of claims 1 to 5, characterized in that: The main body (11) is provided with a positioning protrusion (71) and a positioning groove (72) for accommodating the positioning protrusion (71). The positioning protrusion (71) and the positioning groove (72) correspond to each other one by one. The corresponding positioning protrusions (71) and positioning grooves (72) are symmetrically arranged on both sides of the axis of the pipe head (12).

7. An axial rotation locking aseptic connection device according to any one of claims 1 to 5, characterized in that: It also comprises a pull ring (8), which is fixedly connected to the sterile barrier membrane (3).

8. The axial rotation locking aseptic connection device according to claim 7, characterized in that: The pull ring (8) is provided with a male buckle (81) and a stopper (82) for engaging with the male buckle (81).

9. The axial rotation locking aseptic connection device according to claim 7, characterized in that: The main body (11) is provided with an installation indicator strip (113), and the installation indicator strip (113) is provided on any side surface of the main body (11) parallel to the axis of the pipe head (12).

10. An axial rotation locking aseptic connection device according to any one of claims 1 to 5, characterized in that: A first annular groove (41) is provided on the inner side of the sealing ring (4), and a second annular groove (42) is provided on the outer side of the sealing ring (4). The groove walls of the first annular groove (41) and the second annular groove (42) are both arc-shaped.

11. The axial rotation locking aseptic connection device according to claim 10, characterized in that: The cross-sectional area of ​​the first annular groove (41) is greater than the cross-sectional area of ​​the second annular groove (42).

12. An axial rotation locking aseptic connection device according to any one of claims 1 to 5, characterized in that: It also comprises a protective cover (5), which is located on the side of the sterile barrier film (3) facing away from the connecting member (1) and is detachably fixedly connected to the connecting member (1).

13. The axial rotation locking aseptic connection device according to claim 12, characterized in that: The protective cover (5) comprises a cover body (51) and a gripping portion (52) that is snap-connected to the connecting member (1); a side of the gripping portion (52) close to the connecting member (1) is provided with an anti-slip pattern (521).

14. A sterile docking device, comprising a first sterile connecting member (1) and a second sterile connecting member (1), wherein fluid channels are provided inside the first sterile connecting member (1) and the second sterile connecting member (1), and a sterile flow channel for fluid flow is formed after the first sterile connecting member (1) and the second sterile connecting member (1) are docked, characterized in that: The first aseptic connection component (1) and the second aseptic connection component (1) both adopt the axial rotation locking aseptic connection device according to any one of claims 1 to 13.

15. An aseptic connection system comprising a first container, a second container, and an aseptic docking device connecting the first container and the second container, characterized in that: The sterile docking device adopts the sterile docking device as claimed in claim 14.

16. A sterile connection method, characterized in that: The axial rotation locking aseptic connection device according to any one of claims 1 to 13 comprises the following steps: S1. docking two axially rotating locking aseptic connection devices of the same structure so that the two sterile barrier membranes (3) are in contact with each other with their sides facing away from their corresponding sealing rings (4), and the two sealing rings (4) are aligned; S2, rotating the two axially rotating buckles (2) so that the fastening member (131) of one axially rotating locking aseptic connection device is engaged with the withdrawal stop groove (22) of the other axially rotating locking aseptic connection device; S3. Pull out the two sterile barrier membranes (3) to form a sterile fluid pathway.

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