Core-shell materials, sensors based on core-shell materials, and methods of preparation and use

By loading silver nanoparticles and perovskite quantum dots onto dendritic mesoporous silica nanoparticles and adding an outer gold shell to form a petal-like structure, the instability problem of perovskite quantum dots was solved, and the high sensitivity and high stability of SERS detection of cardiac troponin I were achieved.

CN117340240BActive Publication Date: 2026-06-09FOSHAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FOSHAN UNIVERSITY
Filing Date
2023-08-23
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

In existing technologies, perovskite quantum dots are unstable in water, making it difficult to prepare SERS detection substrate materials with high sensitivity and high stability, resulting in poor detection performance for cardiac troponin I.

Method used

Using dendritic mesoporous silica nanoparticles as the core, silver nanoparticles were synthesized in situ through amino modification, and perovskite quantum dots were loaded onto them. A gold shell was added to form a petal-like structure, and 4-mercaptobenzonitrile was used as a binding site to enhance surface plasmon resonance and Raman hotspot effect.

Benefits of technology

This study improved the sensitivity and stability of SERS detection of cardiac troponin I, achieving high-sensitivity detection with a detection limit of 0.27 pg mL⁻¹.

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Abstract

The present application relates to a core-shell material, a sensor based on the core-shell material, and a preparation method and application thereof. The core-shell material comprises an outer shell and an inner core; the outer shell is coated on the surface of the inner core; the outer shell comprises a metal shell layer; and the inner core comprises dendritic mesoporous silica nanoparticles loaded with perovskite quantum dots and metal particles. The core-shell material of the present application selects dendritic mesoporous silica nanoparticles (DMSNs) as the skeleton of the sensing core, successfully in-situ synthesizes silver nanoparticles in the pore space of the DMSNs through modification of amino groups, and then loads perovskite quantum dots CsPbBr3 on the DMSNs through swelling effect at 150 DEG C. The CsPbBr3@Ag@DMSNs (DAP) can produce a synergistic effect through superposition of chemical enhancement and electromagnetic enhancement, and compared with binary DMSNs, the DAP can improve the responsiveness of SERS to cardiac troponin I.
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