A catalyst composition for preparing methyl isobutyl ketone by one-step acetone process and its application

Abstract

The application discloses a catalyst composition and application thereof, and belongs to the field of chemical industry. The catalyst composition comprises catalyst I and catalyst II, and the molar ratio of catalyst I to catalyst II is 1:5-15. The catalyst I comprises an active component and a carrier. The mass fraction of the active component is 5-10%, and the mass fraction of the carrier is 90-95%. The active component is at least one selected from palladium or platinum. The catalyst II is at least one selected from aluminum chloride, iron chloride, zinc chloride or tin chloride. The catalyst composition provided by the application can obviously improve the conversion rate of acetone and the selectivity of MIBK.

Description

Technical Field

[0001] This invention relates to the field of methyl isobutyl ketone (MEK) preparation technology, specifically to a catalyst composition for one-step preparation of MEK from acetone and its application. Background Technology

[0002] Methyl isobutyl ketone (MIBK) is an important solvent and organic chemical intermediate. MIBK can be used as a solvent in cellulose-based coatings and resin-based coatings such as nitrocellulose and ethyl cellulose, and is also a major raw material for organic chemical products such as rubber antioxidant 6PPD and methyl isobutyl alcohol. With the development of my country's coatings and rubber additives industry in recent years, the demand for MIBK has grown rapidly, and both imports and consumption of MIBK have increased rapidly.

[0003] The preparation of MIBK from acetone mainly involves two methods: a three-step method and a one-step method. The three-step method uses acetone as a raw material, which condenses into diacetone alcohol (DAA) under the action of an alkaline catalyst. DAA is then dehydrated in the liquid phase under an acidic catalyst to produce isopropylidene acetone (MO). MO is then selectively hydrogenated to produce MIBK. This process is characterized by mild reaction conditions, ease of operation, inexpensive catalysts, and low requirements for equipment materials. However, its disadvantages include a long process flow, high investment, and high production costs.

[0004] The one-step process mainly involves completing the three-step reaction of acetone in the first step under catalytic conditions. Acetone undergoes condensation and dehydration to produce MO under the action of a catalyst; then, MO is hydrogenated to produce MIBK. The main products include isopropanol, MIBK, methyl isobutyl alcohol, and diisobutyl ketone (DIBK). The one-step process is short, requires less investment, has high acetone conversion and MIBK selectivity, and low raw material and energy consumption. Because acetone and methyl isobutyl ketone readily undergo hydrogenation to produce isopropanol and methyl isobutyl alcohol, the one-step acetone process must ensure a high conversion rate of acetone while suppressing the ketone-to-alcohol side reaction, placing high demands on the performance of the catalyst.

[0005] To address the aforementioned problems, this invention employs a hybrid catalytic system, achieving both high conversion rate and high selectivity. Summary of the Invention

[0006] In order to overcome the problem that the catalyst in the one-step preparation of methyl isobutyl ketone from acetone in the prior art cannot simultaneously ensure a high conversion rate of acetone and effectively suppress the side reaction of ketone to alcohol, the present invention provides a catalyst composition and its application.

[0007] To solve the above-mentioned technical problems, the first aspect of the present invention provides a catalyst composition comprising catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II in the catalyst composition is 1:5 to 15, for example 1:5, 1:10, 1:7.5, 1:8, or 1:15; catalyst I comprises an active component and a support, wherein the mass fraction of the active component is 5% to 10%, for example 5%, 6%, 8%, or 10%; the mass fraction of the support is 90% to 95%; the active component is selected from at least one of palladium or platinum; and catalyst II is selected from at least one of aluminum chloride, ferric chloride, zinc chloride, or tin chloride.

[0008] According to some embodiments of the present invention, the carrier is selected from at least one of silicon dioxide, alumina and activated carbon.

[0009] A second aspect of the present invention provides a method for preparing a catalyst composition, comprising mixing catalyst I and catalyst II to obtain the catalyst composition.

[0010] According to some embodiments of the present invention, the preparation of catalyst I includes the steps of calcining, oxidizing and ion-exchanging the active component on a support; preferably, the calcination is carried out in an air environment.

[0011] According to some embodiments of the present invention, the calcination temperature is 800-1000℃, for example 800℃, 900℃, 1000℃; the calcination time is 12-48h, for example 12h, 24h, 48h.

[0012] According to some embodiments of the present invention, the oxidation includes oxidizing the calcined support using an oxidizing agent; preferably, the volume ratio of the oxidizing agent to the calcined support is 2 to 5:1, for example 2:1, 3:1, 4:1, 5:1; preferably, the oxidation temperature is 20 to 40°C, for example 20°C, 30°C, 35°C, 40°C, and the oxidation time is 12 to 48 hours, for example 12 hours, 24 hours, 36 hours, 48 ​​hours.

[0013] According to some embodiments of the present invention, the oxidant is hypochlorous acid or hydrogen peroxide; preferably, the concentration of the oxidant is diluted to 1-5% when used, for example, 1%, 2%, 3%, or 5%.

[0014] According to some embodiments of the present invention, the oxidation process includes adjusting the pH and drying the oxidized carrier to a constant mass; preferably, sodium bicarbonate is used to adjust the pH to 7-8, for example 7, 7.5, or 8.

[0015] According to some embodiments of the present invention, the ion exchange includes adding a noble metal solution to the oxidized support; preferably, the volume ratio of the oxidized support to the noble metal solution is 1:1.5 to 3, for example 1:2.5, 1:1.5, 1:3, or 1:2; preferably, the noble metal solution is a palladium chloride solution or a chloroplatinic acid solution.

[0016] According to some embodiments of the present invention, the ion exchange is followed by standing for 1 to 2 hours, for example 1 hour, 1.5 hours, or 2 hours, and then drying the obtained catalyst I to constant weight.

[0017] A third aspect of the present invention provides a reaction for the one-step preparation of methyl isobutyl ketone from acetone, wherein a mixture containing hydrogen and acetone is contacted with a catalyst and reacted to obtain a reaction solution containing methyl isobutyl ketone, and the reaction solution is separated to obtain the methyl isobutyl ketone; wherein the catalyst is one of the catalyst compositions described above or a catalyst composition obtained by the above preparation method.

[0018] According to some embodiments of the present invention, the reaction is a continuous batch reaction;

[0019] And / or, the molar ratio of hydrogen to acetone is 2 to 10:1, preferably 2 to 5:1, for example 2:1, 3:1, 5:1;

[0020] And / or, the molar ratio of acetone to the active component in catalyst I is 1000 to 1500:1, for example 1000:1, 1200:1, 1500:1;

[0021] And / or, the molar ratio of acetone to catalyst II is 100 to 200:1, for example 100, 1, 120, 1, 150, 1, 200, 1;

[0022] And / or, the reaction temperature is 100–150°C, for example, 100°C, 120°C, 150°C;

[0023] And / or, the reaction pressure is 0.5 to 2 MPa, for example 0.5 MPa, 1 MPa, 1.5 MPa, 2 MPa;

[0024] And / or, the reaction time is 0.5 to 1 hour, for example, 0.5 hours, 0.8 hours, or 1 hour.

[0025] According to some embodiments of the present invention, the selectivity of methyl isobutyl ketone in the reaction is 95.1% to 96.4%, for example 95.1%, 95.6%, 96.2%, 96.1%, 96.3%, and 96.4%.

[0026] According to some embodiments of the present invention, the acetone has a purity of ≥99.5% and a water content of ≤0.1%;

[0027] And / or, the acetone conversion rate is 55.2% to 58.4%, for example 55.2%, 58.0%, 57.1%, 58.4%, 57.3%, 57.5%, 56.6%. Controlling the acetone feedstock parameters helps to improve reaction selectivity and extend catalyst life.

[0028] Beneficial effects:

[0029] This invention provides a catalyst composition that combines catalyst I (a noble metal hydrogenation catalyst) and catalyst II (a Lewis acid catalyst). The noble metal hydrogenation catalyst can improve the conversion rate of acetone hydrogenation. Under the condition of the presence of the Lewis acid catalyst, the electron transfer of the two ketone-to-alcohol side reactions, namely acetone hydrogenation to isopropanol and MIBK hydrogenation to MIBC, is affected and the side reactions are suppressed, thereby improving the selectivity of MIBK. Detailed Implementation

[0030] The present invention will be further described below with reference to embodiments. However, the present invention is not limited to these embodiments.

[0031] The palladium chloride used in this invention conforms to GB / T 8185-2020;

[0032] The chloroplatinic acid used in this invention conforms to GB / T 26298-2010;

[0033] In this invention, the carrier has an iodine value ≥1200 mg / g and a specific surface area ≥1300 m². 2 / g.

[0034] The method for calculating the selectivity of methyl isobutyl ketone in this invention is as follows: MIBK selectivity = (amount of acetone corresponding to the generation of MIBK / total conversion of acetone) * 100%;

[0035] The method for calculating acetone conversion rate in this invention is as follows: Acetone conversion rate = Total acetone conversion amount / Feed amount * 100%.

[0036] Example 1

[0037] This embodiment provides a catalyst composition.

[0038] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:10:

[0039] Catalyst I was prepared by calcining Al2O3 at 800℃ for 48 hours in air, followed by oxidation modification with 1% hypochlorous acid. The pH was adjusted to 8 using sodium bicarbonate. The oxidized Al2O3 was dried to constant weight, and then palladium chloride solution was added to the constant-weight oxidized Al2O3 for ion exchange loading of palladium. After standing for 2 hours, the palladium-loaded Al2O3 was dried to constant weight to obtain a palladium / alumina catalyst containing 5 wt% palladium. The volume ratio of hypochlorous acid to Al2O3 was 2:1; the oxidation temperature was 40℃; the oxidation time was 12 hours; and the volume ratio of the constant-weight oxidized Al2O3 to the palladium chloride solution was 1:1.5.

[0040] Catalyst II is aluminum chloride.

[0041] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0042] A one-step process for preparing methyl isobutyl ketone from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing methyl isobutyl ketone. The reaction solution is then separated to obtain the methyl isobutyl ketone. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.5% and a water content of 0.1%. In the one-step process for preparing methyl isobutyl ketone from acetone, the molar ratio of hydrogen to acetone is 2:1, the molar ratio of acetone to palladium in catalyst I is 1000:1, and the molar ratio of acetone to aluminum chloride is 100:1. The reaction conditions are a reaction temperature of 100°C, a reaction pressure of 2 MPa, and a reaction time of 0.5 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0043] Example 2

[0044] This embodiment provides a catalyst composition.

[0045] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:5.

[0046] Catalyst I was prepared by calcining SiO2 at 1000℃ for 12 hours in air, followed by oxidation modification with 5% hydrogen peroxide. The pH was adjusted to 7 using sodium bicarbonate. The oxidized SiO2 was dried to constant weight, and then chloroplatinic acid solution was added to the constant-weight oxidized SiO2 for ion exchange to load platinum metal. After standing for 2 hours, the platinum-loaded SiO2 was dried to constant weight to obtain a platinum / silica catalyst containing 10 wt% platinum. The volume ratio of hydrogen peroxide to SiO2 was 2:1; the oxidation temperature was 20℃; the oxidation time was 12 hours; and the volume ratio of the constant-weight oxidized SiO2 to palladium chloride solution was 1:3.

[0047] Catalyst II is ferric chloride.

[0048] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0049] A one-step process for preparing methyl isobutyl ketone (MOB) from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing MOB. The reaction solution is then separated to obtain the MOB. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.5% and a water content of 0.1%. In the one-step process for preparing MOB from acetone, the molar ratio of hydrogen to acetone is 2:1, the molar ratio of acetone to platinum in catalyst I is 1000:1, and the molar ratio of acetone to ferric chloride is 200:1. The reaction conditions are a reaction temperature of 150°C, a reaction pressure of 0.5 MPa, and a reaction time of 1 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0050] Example 3

[0051] This embodiment provides a catalyst composition.

[0052] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:15.

[0053] Catalyst I was prepared by calcining activated carbon at 1000℃ for 12 hours in air, followed by oxidative modification with 2% hypochlorous acid. The pH was adjusted to 7.5 with sodium bicarbonate. The oxidized activated carbon was dried to constant weight, and then palladium chloride solution was added to the constant-weight oxidized activated carbon for ion exchange loading of palladium. After standing for 1.5 hours, the palladium-loaded activated carbon was dried to constant weight, yielding a palladium / activated carbon catalyst containing 10 wt% palladium. The volume ratio of hypochlorous acid to activated carbon was 3:1; the oxidation temperature was 30℃; the oxidation time was 24 hours; and the volume ratio of the constant-weight oxidized activated carbon to palladium chloride solution was 1:2.

[0054] Catalyst II is zinc chloride.

[0055] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0056] A one-step process for preparing methyl isobutyl ketone (MOB) from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing MOB. The reaction solution is then separated to obtain the MOB. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.6% and a water content of 0.08%. In the one-step process for preparing MOB from acetone, the molar ratio of hydrogen to acetone is 5:1, the molar ratio of acetone to palladium in catalyst I is 1500:1, and the molar ratio of acetone to zinc chloride is 100:1. The reaction conditions are a reaction temperature of 100°C, a reaction pressure of 1 MPa, and a reaction time of 1 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0057] Example 4

[0058] This embodiment provides a catalyst composition.

[0059] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:7.5.

[0060] Catalyst I was prepared by calcining Al2O3 at 900℃ for 24 hours in air, followed by oxidation modification with 3% hydrogen peroxide. The pH was adjusted to 8 using sodium bicarbonate. The oxidized Al2O3 was dried to constant weight, and then palladium chloride solution was added to the constant-weight oxidized Al2O3 for ion exchange loading of palladium. After standing for 1 hour, the palladium-loaded Al2O3 was dried to constant weight to obtain a palladium / alumina catalyst containing 10 wt% palladium. The volume ratio of hydrogen peroxide to Al2O3 was 4:1; the oxidation temperature was 40℃; the oxidation time was 12 hours; and the volume ratio of the constant-weight oxidized Al2O3 to the palladium chloride solution was 1:2.5.

[0061] Catalyst II is tin chloride.

[0062] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0063] A one-step process for preparing methyl isobutyl ketone (MOB) from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing MOB. The reaction solution is then separated to obtain the MOB. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.6% and a water content of 0.1%. In the one-step process for preparing MOB from acetone, the molar ratio of hydrogen to acetone is 5:1, the molar ratio of acetone to palladium in catalyst I is 1500:1, and the molar ratio of acetone to tin chloride is 200:1. The reaction conditions are a reaction temperature of 150°C, a reaction pressure of 1 MPa, and a reaction time of 1 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0064] Example 5

[0065] This embodiment provides a catalyst composition.

[0066] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:8.

[0067] Catalyst I was prepared by calcining Al2O3 at 800℃ for 48 hours in air, followed by oxidation modification with 5% hypochlorous acid. The pH was adjusted to 7 with sodium bicarbonate, and the modified Al2O3 was dried to constant weight. Palladium chloride solution was then added to the constant-weight modified Al2O3 for ion exchange loading of palladium. After standing for 2 hours, the palladium-loaded Al2O3 was dried to constant weight to obtain a palladium / alumina catalyst containing 5 wt% palladium. The volume ratio of hydrogen peroxide to Al2O3 was 3:1; the oxidation temperature was 20℃; the oxidation time was 12 hours; and the volume ratio of the constant-weight modified Al2O3 to the palladium chloride solution was 1:3.

[0068] Catalyst II is aluminum chloride.

[0069] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0070] A one-step process for preparing methyl isobutyl ketone (MOB) from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing MOB. The reaction solution is then separated to obtain the MOB. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.6% and a water content of 0.05%. In the one-step process for preparing MOB from acetone, the molar ratio of hydrogen to acetone is 3:1, the molar ratio of acetone to palladium in catalyst I is 1200:1, and the molar ratio of acetone to aluminum chloride is 150:1. The reaction conditions are a reaction temperature of 120°C, a reaction pressure of 1.5 MPa, and a reaction time of 1 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0071] Example 6

[0072] This embodiment provides a catalyst composition.

[0073] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:10:

[0074] Catalyst I was prepared by calcining Al2O3 at 800℃ for 48 hours in air, followed by oxidation modification with 1% hypochlorous acid. The pH was adjusted to 7 with sodium bicarbonate, and the modified Al2O3 was dried to constant weight. Palladium chloride solution was then added to the constant-weight modified Al2O3 for ion exchange loading of palladium. After standing for 1 hour, the palladium-loaded Al2O3 was dried to constant weight, yielding a palladium / alumina catalyst containing 8 wt% palladium. The volume ratio of hydrogen peroxide to Al2O3 was 2:1; the oxidation temperature was 20℃; the oxidation time was 48 hours; and the volume ratio of the constant-weight modified Al2O3 to the palladium chloride solution was 1:1.5.

[0075] Catalyst II is ferric chloride.

[0076] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0077] A one-step process for preparing methyl isobutyl ketone (MOB) from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing MOB. The reaction solution is then separated to obtain the MOB. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.8% and a water content of 0.05%. In the one-step process for preparing MOB from acetone, the molar ratio of hydrogen to acetone is 3:1, the molar ratio of acetone to palladium in catalyst I is 1200:1, and the molar ratio of acetone to aluminum chloride is 120:1. The reaction conditions are a reaction temperature of 120°C, a reaction pressure of 1.5 MPa, and a reaction time of 0.8 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0078] Example 7

[0079] This embodiment provides a catalyst composition.

[0080] The catalyst composition comprises catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:10:

[0081] Catalyst I was prepared by calcining activated carbon at 1000℃ for 12 hours in air, followed by oxidative modification with 2% hydrogen peroxide. The pH was adjusted to 7 using sodium bicarbonate. The oxidized activated carbon was dried to constant weight, and then chloroplatinic acid solution was added to the constant-weight oxidized activated carbon for ion exchange loading of platinum. After standing for 1 hour, the platinum-loaded activated carbon was dried to constant weight, yielding a platinum / activated carbon catalyst containing 6 wt% platinum. The volume ratio of hydrogen peroxide to activated carbon was 5:1; the oxidation temperature was 35℃; the oxidation time was 36 hours; and the volume ratio of the constant-weight oxidized activated carbon to chloroplatinic acid solution was 1:2.5.

[0082] Catalyst II is ferric chloride.

[0083] Preparation of the catalyst composition: Catalyst I and catalyst II are mixed to obtain the catalyst composition.

[0084] A one-step process for preparing methyl isobutyl ketone (MOB) from acetone includes contacting a mixture of hydrogen and acetone with a catalyst to react and obtain a reaction solution containing MOB. The reaction solution is then separated to obtain the MOB. The catalyst used in the reaction is the aforementioned catalyst composition, and the acetone used in the reaction has a purity of 99.8% and a water content of 0.05%. In the one-step process for preparing MOB from acetone, the molar ratio of hydrogen to acetone is 5:1, the molar ratio of acetone to platinum in catalyst I is 1200:1, and the molar ratio of acetone to aluminum chloride is 120:1. The reaction conditions are a reaction temperature of 120°C, a reaction pressure of 1.5 MPa, and a reaction time of 0.8 h. The calculated acetone conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0085] Comparative Example 1

[0086] According to the preparation method described in Example 1, methyl isobutyl ketone was prepared in one step using acetone, except that the catalyst was Ni, Co / Al2O3. The calculated acetone reaction conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0087] Comparative Example 2

[0088] According to the preparation method described in Example 1, methyl isobutyl ketone was prepared in one step using acetone, except that the catalyst was Pd / resin. The calculated acetone reaction conversion rate and MIBK selectivity are shown in Appendix Table 1.

[0089] Table 1

[0090]

[0091] As can be seen from the results in Table 1 above, the catalyst compositions prepared in Examples 1 to 7 of this application include catalyst I and catalyst II, which can significantly improve the acetone conversion rate and MIBK selectivity in the one-step preparation of methyl isobutyl ketone from acetone. The catalyst compositions prepared in Examples 5 and 7 have the highest MIBK selectivity. In contrast, Comparative Examples 1 and 2 use only a single type of catalyst, and the acetone conversion rate and MIBK selectivity are significantly lower in the one-step preparation of methyl isobutyl ketone from acetone.

[0092] It should be noted that the embodiments described above are only for explaining the present invention and do not constitute any limitation on the present invention. The present invention has been described with reference to typical embodiments, but it should be understood that the words used therein are descriptive and explanatory terms, not limiting terms. Modifications can be made to the present invention within the scope of the claims, and revisions can be made to the present invention without departing from the scope and spirit of the present invention. Although the present invention described herein relates to specific methods, materials, and embodiments, it does not mean that the present invention is limited to the specific examples disclosed herein; on the contrary, the present invention can be extended to all other methods and applications with the same function.

Claims

1. A catalyst composition, characterized in that, The catalyst composition includes catalyst I and catalyst II, wherein the molar ratio of catalyst I to catalyst II is 1:5 to 15; catalyst I comprises an active component and a support, wherein the mass fraction of the active component is 5 to 10% and the mass fraction of the support is 90 to 95%; the active component is selected from at least one of palladium or platinum; the support is selected from at least one of silica, alumina, and activated carbon; and catalyst II is selected from at least one of aluminum chloride, ferric chloride, zinc chloride, or tin chloride. The preparation of catalyst I includes the steps of calcining, oxidizing and ion-exchanging the active component on the support; The oxidation includes oxidizing the calcined carrier with an oxidizing agent; the oxidation process includes adjusting the pH, drying the oxidized carrier to a constant mass, and adjusting the pH to 7-8 using sodium bicarbonate; The oxidant is hypochlorous acid or hydrogen peroxide; The catalyst composition is used to catalyze the preparation of methyl isobutyl ketone from a mixture containing hydrogen and acetone.

2. A method for preparing the catalyst composition as described in claim 1, characterized in that, This includes mixing catalyst I and catalyst II to obtain the catalyst composition; The preparation of catalyst I includes the steps of calcining, oxidizing and ion-exchanging the active component on the support; The oxidation includes oxidizing the calcined carrier with an oxidizing agent; the oxidation process includes adjusting the pH, drying the oxidized carrier to a constant mass, and adjusting the pH to 7-8 using sodium bicarbonate; The oxidant is hypochlorous acid or hydrogen peroxide.

3. The preparation method according to claim 2, characterized in that, The roasting is carried out in an air environment.

4. The preparation method according to claim 2, characterized in that, The calcination temperature is 800–1000℃, and the calcination time is 12–48 hours; And / or, the ion exchange includes adding a noble metal solution to the oxidized support; the noble metal solution is a palladium chloride solution or a chloroplatinic acid solution; And / or, the ion exchange is followed by standing for 1 to 2 hours and drying the obtained catalyst I to constant weight.

5. The preparation method according to claim 4, characterized in that, The volume ratio of the oxidant to the calcined carrier is 2 to 5:1; And / or, the volume ratio of the oxidized support to the noble metal solution is 1:1.5 to 3.

6. The preparation method according to claim 4, characterized in that, The oxidation temperature is 20–40°C, and the oxidation time is 12–48 h.

7. The preparation method according to claim 2, characterized in that, The oxidant is diluted to a concentration of 1-5% before use.

8. A reaction for preparing methyl isobutyl ketone, characterized in that, A mixture containing hydrogen and acetone is contacted with a catalyst and reacted to obtain a reaction solution containing methyl isobutyl ketone; the catalyst is the catalyst composition according to claim 1 or the catalyst composition obtained by any one of claims 2-7.

9. The reaction according to claim 8, characterized in that, In the reaction, the selectivity of methyl isobutyl ketone is 95.1-96.4%.

10. The reaction according to claim 8, characterized in that, The reaction is a continuous batch process. And / or, the molar ratio of hydrogen to acetone is 2 to 10:1; And / or, the molar ratio of acetone to the active component in catalyst I is 1000–1500:1; And / or, the molar ratio of acetone to catalyst II is 100–200:1; And / or, the reaction temperature is 100–150°C; And / or, the reaction pressure is 0.5–2 MPa; And / or, the reaction time is 0.5 to 1 hour.

11. The reaction according to claim 10, characterized in that, The molar ratio of hydrogen to acetone is 2 to 5:

1.

12. The reaction according to claim 8, characterized in that, The acetone has a purity of ≥99.5% and a water content of ≤0.1%. And / or, the acetone conversion rate is 55.2% to 58.4%.

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