Sample needle cleaning method

Abstract

The application discloses a sample needle cleaning method, which is realized through a sample needle washing station, and mainly comprises the following steps: ①initially cleaning the inner and outer walls of the sample needle with pure water; ②cleaning the inner wall of the sample needle again with alkali water; and ③cleaning the inner and outer walls of the sample needle again with pure water. The sample needle cleaning method provided by the application is realized through the sample needle washing station which is simple in structure and easy to assemble, can clean the inner wall and the outer wall of the sample needle, comprehensively improves the cleaning effect, completely eliminates the pollution caused by the sample needle, avoids false positive and other adverse phenomena of the detection result, and sets a second diameter reducing structure in the outer wall cleaning section, so that the flow rate of the cleaning liquid is changed through the diameter reducing structure, the liquid hanging phenomenon of the needle wall is improved, accurate sample adding is realized, and the test precision is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of sample needle cleaning, in particular to a sample needle cleaning method. BACKGROUND

[0002] Biochemical luminescence immunoassay analyzer and other in vitro diagnostic medical devices have the advantages of high sensitivity, wide linear range and convenient and fast operation, and have been widely used in the field of clinical testing. In the detection process, the sample needle needs to absorb the sample and react with the related reagent. If the sample needle is not cleaned thoroughly, it will carry pollution between samples and cause false positive. Secondly, the existing needle cleaning station only cleans the outer wall of the sample needle, ignoring the risk of sample residue on the inner wall of the needle, which will also affect the accuracy of the detection result. Thirdly, when the cleaning approaches the end point, the amount of cleaning liquid decreases, which is easy to cause the cleaning liquid to be adsorbed on the outer wall of the sample needle, forming a hanging liquid phenomenon, which changes the sample adding amount of the needle, and finally affects the test precision. SUMMARY

[0003] In order to solve the above problems, the present application provides a sample needle cleaning method which is completely cleaned, safe and reliable, and the specific technical scheme can be as follows:

[0004] The sample needle cleaning method provided by the present application is realized by a sample needle cleaning station, and the sample needle cleaning method is characterized in that:

[0005] The sample needle cleaning station comprises a cleaning column, the cleaning column is provided with a cleaning cavity, the cleaning cavity is divided into an upper needle outer wall cleaning section and a lower needle inner wall cleaning section; the needle outer wall cleaning section has a first diameter reducing structure and a second diameter reducing structure, the first diameter reducing structure is provided with a pressure cap with an annular elastic nozzle, and the second diameter reducing structure is arranged at the lower part of the first diameter reducing structure; the needle inner wall cleaning section is provided with a needle inner wall cleaning liquid overflow cavity outside, and a flow guide channel is arranged between the needle inner wall cleaning liquid overflow cavity and the needle inner wall cleaning section; the top of the cleaning column is provided with a needle outer wall cleaning liquid inlet joint which is in communication with the annular elastic nozzle, the bottom of the cleaning column is provided with a liquid outlet joint which is in communication with the end of the needle inner wall cleaning section, and the cleaning column is further provided with a needle inner wall cleaning liquid inlet joint and a needle inner wall cleaning liquid overflow joint which are in communication with the needle inner wall cleaning liquid overflow cavity;

[0006] The cleaning method comprises the following steps:

[0007] S1, inserting the sample needle into the cleaning cavity from the pressure cap until the needle tip reaches the needle inner wall cleaning section;

[0008] S2, perform initial cleaning of the inner and outer walls of the sample needle with pure water: remove the piston at the tail of the sample needle, inject pure water into the needle body to clean the inner wall of the needle; at the same time, inject pure water into the annular elastic nozzle through the cleaning fluid inlet connector of the outer wall of the needle, so that the pure water is sprayed out from the annular elastic nozzle to clean the outer wall of the sample needle; after cleaning for a certain period of time, drain the waste liquid in the cleaning chamber through the bottom drain connector.

[0009] S3. Clean the inner wall of the sample needle again with alkaline water: Inject alkaline solution into the overflow chamber of the inner wall cleaning solution through the inlet connector, and let the alkaline solution enter the inner wall cleaning section until the liquid level covers the needle tip suction port; at this time, repeatedly draw the alkaline solution in the inner wall cleaning section through the piston at the tail of the sample needle to clean the inner wall of the needle; after cleaning, open the bottom drain connector to drain the alkaline solution; during this process, adjust the liquid level in the inner wall cleaning section of the needle through the overflow connector.

[0010] S4. Rinse the inner and outer walls of the sample needle with pure water: Follow the method in step two to thoroughly clean the inner and outer walls of the sample needle.

[0011] The pressure cap is screwed to the outer wall cleaning section of the needle, and the outer wall of the nozzle of the elastic nozzle is in close contact with the inner wall of the first diameter reduction structure.

[0012] The needle inner wall cleaning fluid overflow cavity is an annular structure concentrically arranged with the needle inner wall cleaning section, and the top surface of the needle inner wall cleaning fluid overflow cavity is higher than the top surface of the needle inner wall cleaning section.

[0013] The needle inner wall cleaning fluid overflow connector is located above the needle inner wall cleaning fluid inlet connector, and the flow guide channel is located at any position between the needle inner wall cleaning fluid inlet connector and the needle inner wall cleaning fluid overflow connector.

[0014] The flow channel is a horizontal channel connecting the overflow chamber of the cleaning fluid inside the needle and the cleaning section inside the needle.

[0015] The bottom of the cleaning column is provided with a plug that is screwed into the cleaning chamber. A sealing ring is provided on the horizontal mating surface of the plug and the cleaning column. A longitudinal hole is opened in the center of the plug to form the inner wall cleaning section of the needle.

[0016] The inner wall cleaning section of the needle is a through hole with a third diameter reduction structure, and the diameter of the tube above the third diameter reduction structure is larger than the end diameter of the outer wall cleaning section of the needle.

[0017] The needle inner wall cleaning fluid overflow cavity is located on the cleaning column, and the needle inner wall cleaning fluid overflow cavity is arranged around the outer wall of the plug.

[0018] The sample needle cleaning method provided by this invention is achieved through a sample needle washing station with a simple structure and easy assembly. It can clean both the inner and outer walls of the sample needle, comprehensively improving the cleaning effect, completely eliminating contamination carried by the needle, and avoiding adverse phenomena such as false positives in the test results. A second diameter reduction structure is set in the outer wall cleaning section of the needle. By changing the flow rate of the cleaning fluid through this diameter reduction structure, the phenomenon of liquid adhering to the needle wall is improved, accurate sample addition is achieved, and the test accuracy is improved. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the sample needle washing station described in this invention. Detailed Implementation

[0020] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings. These embodiments are implemented based on the technical solution of the present invention, and detailed implementation methods and specific operation processes are given. However, the scope of protection of the present invention is not limited to the following embodiments.

[0021] The sample needle cleaning method described in this invention is implemented using a sample needle washing station. For example... Figure 1 As shown, the sample needle washing station includes a washing column 1, which has a flow channel. A pressure cap 2 is screwed to the top of the flow channel, and a plug 3 is screwed to the bottom. The sample needle washing chamber is composed of the flow channel above the plug 3 (i.e., the needle outer wall washing section) and a longitudinal through hole (i.e., the needle inner wall washing section) opened in the center of the plug 3.

[0022] The aforementioned needle outer wall cleaning section has a first diameter reduction structure 41 and a second diameter reduction structure 42. The end of the pressure cap 2 extends to the first diameter reduction structure 41, and an annular elastic nozzle 21 is installed at its tail. The liquid inlet channel of the elastic nozzle 21 is connected to the needle outer wall cleaning liquid inlet connector 5. The outer wall of its nozzle is in close contact with the inner wall of the first diameter reduction structure 41 (for specific structure, please refer to ZL201410365228.0 Reagent Needle Washing Station), so that the cleaning liquid is sprayed out in a circumferential high pressure, thereby thoroughly cleaning the outer wall of the sample needle. To avoid liquid adhering to the needle outer wall, a second diameter reduction structure 42 is also provided below the first diameter reduction structure 41. When the cleaning liquid passes through the second diameter reduction structure 42, the flow channel becomes smaller, and the flow rate of the cleaning liquid increases. When it passes through the outer wall of the sample needle at high speed, it can carry away residual droplets, thereby avoiding liquid adhering to the surface of the sample needle and causing contamination.

[0023] The longitudinal through-hole (i.e., the needle inner wall cleaning section) in the center of the plug 3 has a third diameter reduction structure 6. The diameter of the tube above the third diameter reduction structure 6 is larger than the end diameter of the needle outer wall cleaning section. After the plug 3 is installed, the needle inner wall cleaning section can easily connect with the needle outer wall cleaning section above, thereby reducing the assembly difficulty. In addition, the larger tube diameter section is beneficial for storing the needle inner wall cleaning fluid, making it convenient for the sample needle to aspirate the cleaning fluid for inner wall cleaning.

[0024] Because the cleaning fluid entering the inner wall of the needle directly would splash onto the sample needle, affecting its liquid level detection function, an overflow cavity 7 for the cleaning fluid is provided on the outside of the inner wall cleaning section and connected to it (through a horizontal channel). This overflow cavity 7 is a ring-shaped structure concentrically positioned with the inner wall cleaning section, located on the cleaning column 1, and surrounding the outer wall of the plug 3. To prevent leakage, a sealing ring 8 is installed on the horizontal mating surface between the plug 3 and the cleaning column 1.

[0025] Normally, the top surface of the needle inner wall cleaning fluid overflow chamber 7 is higher than the top surface of the needle inner wall cleaning section. The cleaning column 1 is equipped with a needle inner wall cleaning fluid inlet connector 9 and a needle inner wall cleaning fluid overflow connector 10, both connected to the needle inner wall cleaning fluid overflow chamber 7. The needle inner wall cleaning fluid overflow connector 10 is positioned above the needle inner wall cleaning fluid inlet connector 9. A flow channel connecting the needle inner wall cleaning section and the needle inner wall cleaning fluid overflow chamber 7 can be provided at any position between them. Furthermore, a drain connector 11, connected to the end of the needle inner wall cleaning section, is provided at the bottom of the cleaning column 1 to drain the cleaning fluid from the cleaning chamber.

[0026] The sample needle washing station described above cleans the sample needles by primarily including: ① initial cleaning of the inner and outer walls of the sample needle with pure water; ② secondary cleaning of the inner wall of the sample needle with alkaline water; and ③ final cleaning of the inner and outer walls of the sample needle with pure water. Details are as follows:

[0027] S1, insert the sample needle into the cleaning chamber from inside the pressure cap 2 until the needle tip reaches the cleaning section of the inner wall of the needle.

[0028] S2, perform initial cleaning of the inner and outer walls of the sample needle with pure water: remove the piston at the tail of the sample needle, inject pure water into the needle body to clean the inner wall of the needle (only water is ejected); at the same time, inject pure water into the elastic nozzle 21 through the cleaning fluid inlet connector 5 of the outer wall of the needle, so that the pure water is sprayed out from the elastic nozzle 21 to clean the outer wall of the sample needle; after cleaning for a certain period of time, drain the waste liquid in the cleaning chamber through the bottom drain connector 11.

[0029] S3. The inner wall of the sample needle is cleaned again with alkaline water: Alkaline solution is injected into the needle inner wall cleaning solution overflow chamber 7 through the inlet connector 9. After the liquid level rises, it enters the needle inner wall cleaning section through the horizontal channel until the liquid level covers the needle tip suction port. At this time, the alkaline solution in the needle inner wall cleaning section is repeatedly drawn up by the piston at the tail of the sample needle to clean the needle inner wall. After cleaning, the bottom drain connector 11 is opened to drain the alkaline solution. During this process, if the liquid level in the needle inner wall cleaning section is too high, the alkaline solution will be discharged through the needle inner wall cleaning solution overflow connector 10 to prevent the alkaline solution from flowing upward through the guide channel of the cleaning column 1 and damaging the elastic nozzle 21.

[0030] S4. Rinse the inner and outer walls of the sample needle with pure water: Follow the steps in S1 to thoroughly clean the inner and outer walls of the sample needle.

[0031] It should be noted that in the description of this invention, terms such as "front," "rear," "left," "right," "vertical," "horizontal," "inner," and "outer" indicating orientation or positional relationships are based on the orientation or positional relationships shown in the accompanying drawings. They are used only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

Claims

1. A method for cleaning sample needles, implemented through a sample needle washing station, characterized in that: The sample needle washing station includes: a washing column, wherein a washing chamber is provided inside the washing column, the washing chamber being divided into an upper needle outer wall washing section and a lower needle inner wall washing section; the needle outer wall washing section has a first diameter reduction structure and a second diameter reduction structure, wherein a pressure cap with an annular elastic nozzle is provided at the first diameter reduction structure, and the second diameter reduction structure is spaced apart at the lower part of the first diameter reduction structure; a needle inner wall washing fluid overflow chamber is provided on the outside of the needle inner wall washing section, and a guide channel is provided between the needle inner wall washing fluid overflow chamber and the needle inner wall washing section; a needle outer wall washing fluid inlet connector connected to the annular elastic nozzle is provided at the top of the washing column, and a drain connector connected to the end of the needle inner wall washing section is provided at the bottom of the washing column; the washing column is also provided with a needle inner wall washing fluid inlet connector and a needle inner wall washing fluid overflow connector connected to the needle inner wall washing fluid overflow chamber; The cleaning method includes: S1, insert the sample needle into the cleaning chamber from inside the pressure cap until the needle tip reaches the cleaning section of the inner wall of the needle; S2, perform initial cleaning of the inner and outer walls of the sample needle with pure water: remove the piston at the tail of the sample needle, inject pure water into the needle body to clean the inner wall of the needle; at the same time, inject pure water into the annular elastic nozzle through the cleaning fluid inlet connector of the outer wall of the needle, so that the pure water is sprayed out from the annular elastic nozzle to clean the outer wall of the sample needle; after cleaning for a certain period of time, drain the waste liquid in the cleaning chamber through the bottom drain connector. S3. Clean the inner wall of the sample needle again with alkaline water: Inject alkaline solution into the overflow chamber of the inner wall cleaning solution through the inlet connector, and let the alkaline solution enter the inner wall cleaning section until the liquid level covers the needle tip suction port; at this time, repeatedly draw the alkaline solution in the inner wall cleaning section through the piston at the tail of the sample needle to clean the inner wall of the needle; after cleaning, open the bottom drain connector to drain the alkaline solution; during this process, adjust the liquid level in the inner wall cleaning section of the needle through the overflow connector. S4. Rinse the inner and outer walls of the sample needle with pure water: Follow the method in S2 to thoroughly clean the inner and outer walls of the sample needle.

2. The sample needle cleaning method according to claim 1, characterized in that: The pressure cap is screwed to the outer wall cleaning section of the needle, and the outer wall of the nozzle of the elastic nozzle is in close contact with the inner wall of the first diameter reduction structure.

3. The sample needle cleaning method according to claim 1, characterized in that: The needle inner wall cleaning fluid overflow cavity is an annular structure concentrically arranged with the needle inner wall cleaning section, and the top surface of the needle inner wall cleaning fluid overflow cavity is higher than the top surface of the needle inner wall cleaning section.

4. The sample needle cleaning method according to claim 3, characterized in that: The needle inner wall cleaning fluid overflow connector is located above the needle inner wall cleaning fluid inlet connector, and the flow guide channel is located at any position between the needle inner wall cleaning fluid inlet connector and the needle inner wall cleaning fluid overflow connector.

5. The sample needle cleaning method according to claim 3, characterized in that: The flow channel is a horizontal channel connecting the overflow chamber of the cleaning fluid inside the needle and the cleaning section inside the needle.

6. The sample needle cleaning method according to claim 5, characterized in that: The bottom of the cleaning column is provided with a plug that is screwed into the cleaning chamber. A sealing ring is provided on the horizontal mating surface of the plug and the cleaning column. A longitudinal hole is opened in the center of the plug to form the inner wall cleaning section of the needle.

7. The sample needle cleaning method according to claim 6, characterized in that: The inner wall cleaning section of the needle is a through hole with a third diameter reduction structure, and the diameter of the tube above the third diameter reduction structure is larger than the end diameter of the outer wall cleaning section of the needle.

8. The sample needle cleaning method according to claim 7, characterized in that: The needle inner wall cleaning fluid overflow cavity is located on the cleaning column, and the needle inner wall cleaning fluid overflow cavity is arranged around the outer wall of the plug.

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