A pesticide synergist, its preparation method and application

Abstract

This invention provides a pesticide synergist, its preparation method, and its application, belonging to the field of pesticide adjuvants. The pesticide synergist provided by this invention comprises, by weight percentage, 3.5-4.5% lauric acid, 5.5-6.5% diacetone alcohol, 10-15% emulsifier, and 74-80% solubilizer. The pesticide synergist provided by this invention is environmentally friendly, can improve the contact and adhesion between the active ingredient of the pesticide and its application site, improve the efficiency of pesticide use, and can still maintain high efficacy while reducing the dosage of herbicides, insecticides, and fungicides. Ultimately, it reduces environmental pollution, increases crop yield, lowers costs, and increases profits.

Description

Technical Field

[0001] This invention belongs to the field of pesticide adjuvant technology, specifically relating to a pesticide synergist, its preparation method, and its application. Background Technology

[0002] With societal progress, agricultural development has entered a new stage of accelerated and comprehensive green transformation, placing new and higher demands on reducing pesticide use and increasing efficiency. Currently, pesticide use is inefficient, and the large quantities used have an increasingly severe environmental impact. Therefore, many pesticide adjuvants have emerged. Commonly used agricultural adjuvants include mineral oils, nonionic surfactants, and vegetable oils. Agricultural adjuvants are developing towards environmental protection and high efficiency, and vegetable oil adjuvants are currently the most promising. Vegetable oil adjuvants can be added to pesticide products as formulation adjuvants, possessing excellent properties such as wide applicability, environmental friendliness, and good biodegradability. However, the variety of commercially available vegetable oil adjuvants is relatively limited, and their synergistic effects are not ideal.

[0003] Therefore, there is an urgent need for an environmentally friendly pesticide synergist that enhances the efficacy of pesticides. Summary of the Invention

[0004] In view of this, the purpose of this invention is to provide a pesticide synergist, its preparation method and application, which can improve the surface tension and contact angle of pesticides, improve pesticide application efficiency, reduce pesticide usage, and has the effects of environmental protection, increased yield and increased income.

[0005] To achieve the above objectives, the present invention provides a pesticide synergist, wherein the components of the pesticide synergist, by weight percentage, include 3.5-4.5% lauric acid, 5.5-6.5% diacetone alcohol, 10-15% emulsifier, and 74-80% cosolvent.

[0006] Preferably, the pesticide synergist comprises, by weight percentage, 4.2% lauric acid, 6.3% diacetone alcohol, 13% emulsifier, and 76.5% n-hexanol.

[0007] In this invention, diacetone alcohol can be used as a drug preservative and antifreeze agent; lauric acid has antibacterial, antiviral and antibacterial and fungal growth inhibition functions (herpes, influenza, Helicobacter pylori). Through the combination and efficacy of the two, the surface tension and contact angle of pesticides can be improved, and the efficiency of pesticide use can be improved.

[0008] Preferably, the emulsifier is a mixture of Span 80 and Tween 80 in a weight ratio of 1.40 to 2.34:3.13.

[0009] Preferably, the emulsifier has an HLB value of 10 to 12.

[0010] Preferably, the pesticide synergist is an emulsifiable concentrate.

[0011] Preferably, the co-solvent is n-hexanol, isohexanol, ethanol, propanol, or acetone.

[0012] Preferably, it includes the following steps:

[0013] (1) Weigh the raw materials according to the stated weight percentage;

[0014] (2) Stir n-hexanol, emulsifier, lauric acid and diacetone alcohol at 30-40℃ for 3-5 minutes, and obtain pesticide synergist after cooling.

[0015] Preferably, the mixing is carried out under water bath heating.

[0016] The present invention also provides the application of the pesticide synergist in the preparation of pesticides.

[0017] Preferably, the pesticide includes herbicides, fungicides, or insecticides.

[0018] Preferably, the herbicide is clodinafop-propargyl, nicosulfuron, atrazine, or nicosulfuron; the fungicide is chlorothalonil or copper acetate; and the insecticide is imidacloprid or matrine.

[0019] Preferably, the amount of the pesticide synergist is 0.5 wt% of the amount of water used in the pesticide application.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] (1) The pesticide synergist provided by the present invention can reduce the surface tension and contact angle of pesticides, thereby enabling the active ingredients in pesticides to fully contact and adhere to the action point, thus improving the pesticide's effect;

[0022] (2) The pesticide synergist provided by the present invention can be compounded with a variety of pesticides, so that the dosage of herbicide, fungicide and insecticide can be reduced while still having the effect of normal pesticide dosage;

[0023] (3) The pesticide synergist provided by the present invention requires a small amount, has no pollution to the environment, reduces the cost of pesticide application in the field, increases crop yield, and increases profits. Detailed Implementation

[0024] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention. Unless otherwise specified, the experimental methods used in the embodiments are all conventional methods; the materials and reagents used are all commercially available.

[0025] Lauric acid was purchased from Shanghai Bid Pharmaceutical Technology Co., Ltd.; diacetone alcohol was purchased from Shanghai Maclean Biochemical Technology Co., Ltd.; Span 80 was purchased from Tianjin Fuchen Chemical Reagent Factory; Tween 80 was purchased from Tianjin Fuchen Chemical Reagent Factory.

[0026] Nicosulfuron suspension was purchased from Tianjin Huayu Pesticide Co., Ltd.; atrazine dispersible oil suspension was purchased from Dezhou Xianglong Biochemical Co., Ltd.; nitrazepam atrazine dispersible oil suspension was purchased from Hebei Zhongbaolv Crop Technology Co., Ltd.; chlorothalonil was purchased from Limin Chemical Co., Ltd.; and imidacloprid was purchased from Sunong (Guangde) Biotechnology Co., Ltd.

[0027] Example 1

[0028] (1) Weigh out 28% Span 80 and 72% Tween 80 by weight and mix them evenly to obtain an emulsifier with an HLB value of 10;

[0029] (2) Weigh out 3.5% lauric acid, 5.5% diacetone alcohol, 11% emulsifier, and 80% n-hexanol by weight;

[0030] (3) Hexanol, emulsifier, lauric acid and diacetone alcohol are stirred in a water bath at 30°C for 5 minutes and then cooled to obtain pesticide synergist.

[0031] Example 2

[0032] (1) Weigh out 37.3% Span 80 and 62.7% Tween 80 by weight and mix them evenly to obtain an emulsifier with an HLB value of 13;

[0033] (2) Weigh out 4.5% lauric acid, 6.5% diacetone alcohol, 15% emulsifier, and 74% isohexanol by weight;

[0034] (3) Hexanol, emulsifier, lauric acid and diacetone alcohol are stirred in a water bath at 40°C for 4 minutes and then cooled to obtain pesticide synergist.

[0035] Example 3

[0036] (1) Weigh out 46.7% Span 80 and 53.3% Tween 80 by weight and mix them evenly to obtain an emulsifier with an HLB value of 11;

[0037] (2) Weigh out 4.2% lauric acid, 6.3% diacetone alcohol, 13% emulsifier, and 76.5% n-hexanol by weight;

[0038] (3) Hexanol, emulsifier, lauric acid and diacetone alcohol are stirred in a water bath at 35°C for 3 minutes and then cooled to obtain pesticide synergist.

[0039] Comparative Example 1

[0040] (1) Weigh out 46.7% Span 80 and 53.3% Tween 80 by weight and mix them evenly to obtain an emulsifier with an HLB value of 11;

[0041] (2) Weigh out 10.5% lauric acid, 13% emulsifier, and 76.5% n-hexanol by weight;

[0042] (3) Hexanol, emulsifier, lauric acid and diacetone alcohol are stirred in a water bath at 35°C for 3 minutes and then cooled to obtain pesticide synergist.

[0043] Comparative Example 2

[0044] (1) Weigh out 46.7% Span 80 and 53.3% Tween 80 by weight and mix them evenly to obtain an emulsifier with an HLB value of 11;

[0045] (2) Weigh out 10.5% diacetone alcohol, 13% emulsifier, and 76.5% n-hexanol by weight;

[0046] (3) Hexanol, emulsifier, lauric acid and diacetone alcohol are stirred in a water bath at 35°C for 3 minutes and then cooled to obtain pesticide synergist.

[0047] Experimental Example 1

[0048] The surface tension and contact angle of the pesticide synergist obtained in Example 3 were measured.

[0049] 1. The pesticide synergists obtained in Example 3, Comparative Example 1, and Comparative Example 2 were prepared into aqueous solutions of 0.01%, 0.05%, 0.1%, 0.5%, and 1%, respectively. Under room temperature (25°C) conditions, 30 mL of each aqueous solution was taken and the surface tension was measured using a JK99B surface tension meter. 1 μL of each solution was taken and the contact angle of the different systems was measured using a JG2000DM contact angle meter. Each treatment was repeated 5 times. The results are shown in Table 1.

[0050] Table 1. Screening results of pesticide synergist adjuvant dosage.

[0051]

[0052]

[0053] Note: All data in the table are mean ± standard deviation, and different letters indicate significant differences (p<0.05).

[0054] The measurement results show that the pesticide synergists in Comparative Example 1 and Comparative Example 2 are single active ingredients, and their solution surface tension and contact angle did not change significantly, so they could not play the corresponding role.

[0055] In Example 3 of this application, the use of pesticide synergist reduced the surface tension and contact angle of the solution. When the addition amount was 0.5%, the surface tension of the solution was 31.33 mN / m and the contact angle was 69.21°. The difference in surface tension and contact angle between the addition amount and 1% was not significant. Therefore, the final determination of the pesticide synergist addition amount was 0.5% of the water content of the pesticide dilution.

[0056] 2. The surface tension and contact angle of the pesticide synergist obtained in Example 3, which consisted of herbicides nicosulfuron, nicotinamide, and clodinafop-propargyl; fungicide chlorothalonil; and insecticide imidacloprid diluted at the recommended dosage and then mixed with 0.5% water content of the pesticide dilution solution, were measured. The results are shown in Table 2.

[0057] Table 2. Test results of pesticide compounding adjuvants.

[0058]

[0059] According to Table 2, the pesticide synergist in Example 3, when combined with herbicides, fungicides, and insecticides, can reduce their surface tension and contact angle.

[0060] Experiment Example 2

[0061] The synergistic activity of the pesticide synergist in Example 3 on pesticides was determined.

[0062] 1. The synergistic activity of pesticide adjuvants against herbicides was determined in laboratory experiments.

[0063] The experiment was designed according to the "Guidelines for Indoor Bioassay Testing of Pesticides - Herbicides Part 4: Activity Assay Tests - Foliar Spraying" (NYT1155.4-2006). A pesticide synergist was mixed with a reduced dose of a commonly used herbicide (the synergist was added at 0.5% of the water content of the pesticide dilution). A 3WP-2000 mobile spray tower was used to spray the test weeds at the 2-3 leaf stage, with a spray volume of 450 L / m². 2 Seven and fourteen days after spraying, the fresh weight of the above-ground portion of the weeds was measured, and the fresh weight inhibition rate was calculated. The results are shown in Table 3.

[0064] Table 3. Indoor test results of post-emergence control efficacy of pesticide synergists and herbicide reduction formulations.

[0065]

[0066] Note: All data in the table are mean ± standard deviation, and different letters indicate significant differences (p<0.05).

[0067] As can be seen from the table above, the pesticide synergist prepared in this application has a synergistic effect on herbicides. The synergistic effect is more obvious when it is combined with 4% nicosulfuron, 15% clodinafop-propargyl, and 27% nicotinate at a 30% reduction.

[0068] 2. The synergistic activity of pesticide adjuvants against herbicides was determined in field trials.

[0069] Experimental location: Cornfield in Xushui District, Baoding City; Experimental drugs: Nicosulfuron suspension, nicotine sulfide, and nicotine sulfide; Experimental crop: Zhengdan 958 corn.

[0070] The pesticide formulations were based on field-recommended dosages for 4% nicosulfuron suspension, 26% nicosulfuron-methyl oil dispersible suspension, and 27% nicosulfuron-methyl oil dispersible suspension, with manual weeding and a blank control included. (The pesticide synergist was added at 0.5% of the water content of the pesticide dilution.)

[0071] The test cells were randomly distributed, with each cell having an area of ​​10m². 2 Each treatment was repeated three times. All maize varieties planted in the experimental area were Zhengdan 958. No other herbicides were applied throughout the entire maize growing season except for the selected herbicide; the spraying rate was 450 L / hm². 2 .

[0072] Field weed control efficacy survey: The survey was conducted according to GB / T 17980.42-2000 standard. Five points were randomly selected in each plot at 7 days and 14 days after application, with each point measuring 0.25m. 2 Weed count by species: 28 days after application, the same method as 14 days was used to count the number of weeds and their above-ground fresh weight in each plot by species.

[0073] The formula for calculating the prevention and control effect is:

[0074] In the formula: CK—number of weeds or fresh weight in the control area;

[0075] PT—Number of weeds or fresh weight in the treatment area.

[0076] The corn yield was calculated as follows: Since the corn in the experimental area was to be processed as silage corn, data collection was conducted before harvesting with a silage corn harvester. Three points were randomly selected in the experimental field for data collection. At each point, the row spacing (10 rows) and plant spacing (30 plants per row) were measured to calculate the effective number of ears per mu (unit of land area). Subsequently, in each plot, 15 consecutive ears from adjacent double rows were selected, and the number of rows and kernels per row were counted to calculate the number of kernels per ear. The 100-kernel weight or 1000-kernel weight of the corn variety was obtained from relevant data. The yield of each plot was calculated using a reduction factor of 0.85, as shown in the following formula:

[0077]

[0078] The control efficacy of herbicide-pesticide synergistic adjuvants is shown in Table 4, and the effect of herbicide-pesticide synergistic adjuvants on corn yield is shown in Table 5.

[0079] Table 4. Control efficacy based on number of plants at 7 and 14 days post-emergence and control efficacy based on fresh weight at 28 days post-emergence.

[0080]

[0081] Note: All data in the table are mean ± standard deviation, and different letters indicate significant differences (p<0.05).

[0082] When pesticide synergist was combined with a 30% reduction in the dosage of 4% nicosulfuron suspension, the control efficacy against weeds at 7 and 14 days was 78.74% and 88.37%, respectively, and the control efficacy against fresh weight at 28 days was 85.48%. When pesticide synergist was combined with a 30% reduction in the dosage of 26% nicotine-atrazine dispersible oil suspension, the control efficacy against weeds at 7 and 14 days was 79.89% and 86.05%, respectively, and the control efficacy against fresh weight at 28 days was 73.57%. When pesticide synergist was combined with a 30% reduction in the dosage of 27% nicotine-atrazine dispersible oil suspension, the control efficacy against weeds at 7 and 14 days was 89.66% and 90.70%, respectively, and the control efficacy against fresh weight at 28 days was 81.12%. According to the data above, when the amount of herbicide used is reduced by 30% and combined with the pesticide synergist of this application, the weeding effect is the same as that of normal dosage, indicating that it can play a role in reducing the amount of herbicide used and increasing its effectiveness.

[0083] Table 5. Corn Yield Monitoring Table

[0084]

[0085] 3. Determination of the synergistic activity of pesticide adjuvants against fungicides

[0086] The mycelial growth rate method was used to determine the antibacterial activity of pesticide synergists against fungicides (the amount of pesticide synergists added was 0.5% of the water content of the pesticide dilution). Experimental method: The mycelial growth rate method was used to determine the synergistic activity of lauric acid-diacetone alcohol adjuvant combined with fungicide against eggplant wilt disease. First, prepare the treatment plates: dilute the test agent to the required concentration, mix the melted PDA medium cooled to about 50℃ with the drug solution at a volume ratio of 9:1, and then pour it into a disposable petri dish with a diameter of 9cm. A plate with an equal volume of sterile water added to the drug solution was used as a control. After the treatment plates solidified for 24 hours, the mycelial cake of eggplant wilt pathogen was cut with a punch and inoculated into the center of the drug-containing plate. Each treatment was repeated 3 times. After inoculation, the plates were placed in an incubator at (30±1)℃ for 5-7 days. The colony size was represented by the average diameter of the colony measured by the cross-cross method. The inhibition rate was calculated using the following formula:

[0087] Colony expansion diameter (mm) = average colony diameter (mm) - mycelial cake diameter (mm);

[0088]

[0089] The measurement results are shown in Table 6.

[0090] Table 6. Determination of the effect of pesticide synergists on the antifungal activity of fungicides.

[0091]

[0092]

[0093] Note: All data in the table are mean ± standard deviation, and different letters indicate significant differences (p<0.05).

[0094] As shown in Table 6, chlorothalonil, even with the addition of pesticide synergists at the recommended dosage, still exhibits inhibitory activity against Fusarium oxysporum and demonstrates a synergistic effect with chlorothalonil fungicides. Even with a 20% reduction in the recommended dosage, the combined pesticide synergists maintain an inhibition rate of over 95%.

[0095] 4. Determination of the synergistic activity of pesticide adjuvants against insecticides

[0096] The antibacterial activity of pesticide synergists against insecticides was determined using the leaf-immersion method (the amount of pesticide synergist added was 0.5% of the water content of the pesticide dilution). Experimental method: The synergistic activity of lauric acid-diacetone alcohol synergist against insecticides was determined using the leaf-immersion method. Plant leaves of uniform growth were selected, cut into suitable leaf segments, and immersed in the prepared pesticide solution for 10 seconds. After removal, the segments were air-dried and placed in petri dishes containing moisturizing filter paper. Standard test insects with consistent physiological states and continuous indoor culture were introduced into the petri dishes. Each treatment was repeated three times, and a control group without treatment was set up.

[0097] The formula for calculating the mortality rate of the insect population is as follows:

[0098]

[0099] The measurement results are shown in Table 7.

[0100] Table 7. Determination of the insecticidal activity enhancement of pesticides by pesticide synergists.

[0101]

[0102]

[0103] Note: All data in the table are mean ± standard deviation, and different letters indicate significant differences (p<0.05).

[0104] As shown in Table 7, imidacloprid, even with a reduced dosage and the addition of pesticide synergists, still exhibits good control effects against pea aphids and has a certain synergistic effect on imidacloprid insecticides.

[0105] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A pesticide synergist, characterized in that, The components of the pesticide synergist include lauric acid 3.5-4.5%, diacetone alcohol 5.5-6.5%, emulsifier 10-15%, and cosolvent 74-80% by weight percentage; The emulsifier is a mixture of Span 80 and Tween 80 in a weight ratio of 1.40-2.34:3.13; The cosolvent is n-hexanol, isohexyl alcohol, ethanol, propanol or acetone.

2. The pesticide synergist according to claim 1, characterized in that, The components of the pesticide synergist include lauric acid 4.2%, diacetone alcohol 6.3%, emulsifier 13%, and n-hexanol 76.5% by weight percentage.

3. The pesticide synergist according to claim 1, characterized in that, The HLB value of the emulsifier is 10-12.

4. The method for preparing the pesticide synergist according to any one of claims 1-3, characterized in that, The method comprises the following steps: (1) weighing the raw materials according to the weight percentage; (2) stirring n-hexanol, emulsifier, lauric acid and diacetone alcohol at 30-40℃ for 3-5 min, and obtaining the pesticide synergist after cooling.

5. Use of the pesticide synergist according to any one of claims 1 to 3 for the preparation of herbicides, fungicides or insecticides, characterized in that, The herbicide is clodinafop-propargyl, nicosulfuron, ametryn or nitrapyrin; the fungicide is chlorothalonil; and the insecticide is imidacloprid.

6. Use according to claim 5, characterized in that, The dosage of the pesticide synergist is 0.5wt% of the water used for the pesticide.

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