A plant extract feed additive for improving prolonged labor of pregnant sows and application thereof

Abstract

This invention belongs to the field of feed additives, specifically disclosing a plant extract feed additive and its application for improving prolonged labor in pregnant sows. The applicant discovered that using mangosteen peel extract in feed additives can shorten the labor time in pregnant sows, thereby improving their reproductive performance. The feed additive prepared by compounding mangosteen peel extract with extracts of white clover, licorice, ginger, and astragalus allows the plant active ingredients to better exert their dual effects of medicine and nutrition, meeting the nutritional needs of pregnant sows, exhibiting good palatability, shortening sow labor time, reducing stillbirth rates, and improving sow reproductive performance. It also has advantages such as low toxicity, no drug resistance, and minimal residue, reducing potential food safety risks.

Description

Technical Field

[0001] This invention belongs to the field of feed additives, specifically relating to a plant extract feed additive for improving prolonged labor in pregnant sows and its application. Technical Background

[0002] Stillbirth is a key indicator affecting sow reproductive performance. Its occurrence is influenced by genetic, sow, piglet, and environmental factors, but the length of labor is directly related to stillbirth. When labor lasts longer than 5 hours, the number of stillbirths increases significantly. Parturition is a crucial part of livestock production. Problems during parturition have a serious impact on herd productivity and animal health. Parturition not only affects sow productivity but also her productive lifespan. Therefore, shortening the sow's parturition time promotes the growth and development of newborn piglets and improves sow reproductive efficiency, thereby further reducing costs and increasing economic benefits. However, due to the extensive use of antibiotics, drug resistance and drug residues are becoming increasingly serious problems. Simultaneously, with the growing demand for high-quality agricultural products and green foods, developing new non-toxic, harmless, and residue-free feed additives has become a new direction for promoting the healthy development of animal husbandry.

[0003] During farrowing, sows undergo a rapid series of hormonal and metabolic changes. While decades of breeding have significantly improved sow productivity, such as litter size, the increased nutritional and environmental stresses have also led to decreased tolerance and weakened constitution. Therefore, farrowing is easily affected by both the sow's own physical condition and surrounding factors. Firstly, genetic factors, particularly breed, can significantly influence the sow's labor process and thus the duration of farrowing. Imported lean breeds like Duroc tend to have a 1-2 hour longer labor compared to domestic breeds, possibly due to differences in adaptability and stress levels. Secondly, maternal factors, such as body condition (immunity, stress level), parity, gestational age, backfat thickness, total litter size, and constipation, can all affect the duration of farrowing. Finally, farrowing is an extremely complex process. During farrowing, the sow's uterine smooth muscle and other parturition-related muscles become more active, effective circulating blood volume decreases, placental glucose catabolism increases, and placental glycolysis accelerates. Sows are often fed a restricted diet for three days before farrowing, which puts them in a relatively hungry state at the time of farrowing. This state causes the placenta to further increase its energy supply. After glycogen is depleted, glycolysis is enhanced, and more metabolic intermediates such as lactic acid and pyruvic acid are produced.

[0004] Currently, pig farms mainly use exogenous oxytocin to assist in farrowing and address prolonged labor in sows. However, overuse of oxytocin is also common, leading to uterine spasms, poor farrowing efficacy, and significant harm to both the sow and fetus. Furthermore, oxytocin is suitable for single-parity animals such as cattle and horses, but is contraindicated in multiparity sows or single-parity sows carrying multiple litters. Therefore, the use of plant extracts to increase sow immunity and enhance uterine contractions during farrowing, addressing the problem of prolonged labor in sows, is scientifically sound. Summary of the Invention

[0005] The purpose of this invention is to provide a plant extract feed additive for improving prolonged labor in pregnant sows, wherein the feed additive is mangosteen peel extract.

[0006] Another objective of this invention is to provide the application of mangosteen peel extract as a feed additive. Adding the plant extract feed additive of this invention to the diet of pregnant sows can effectively improve the prolonged labor process, enhance the reproductive performance and immunity of sows, and help reduce the problem of antibiotic residues in the breeding process.

[0007] To achieve the above objectives, the present invention adopts the following technical measures:

[0008] A plant extract feed additive for improving prolonged labor in pregnant sows, comprising:

[0009] Mangosteen peel extract 30-40 parts, white flower vine fruit extract 20-30 parts, ginger extract 15-20 parts, licorice extract 10-15 parts, astragalus extract 10 parts, by weight.

[0010] The preparation method of the mangosteen peel extract includes: mixing mangosteen peel powder with pure water at a material-to-liquid ratio of 1:20-40 (g / mL), ultrasonicating for 10-20 min, centrifuging at 2500-3500 r / min for 15-30 min to separate the solid and liquid phases, and removing the filtrate; adding the filter residue and 60-80% ethanol solution at a material-to-liquid ratio of 1:20-40 (g / mL) into an electric pulse-ultrasonic extraction cell, with an electric field strength of 6-8 kV / cm, a pulse frequency of 400-600 Hz, and an ultrasonic frequency of 9-11 Hz. Extraction was performed at 38-42℃ for 20-50 min at kHz, followed by centrifugation at 2500-3500 rpm for 10-20 min. The supernatant was collected, and the residue was added to a 60-80% ethanol solution at a material-to-liquid ratio of 1:25-40 (g / mL) in an ultrasonic extraction vessel for 20-40 min. The residue was then centrifuged at 2500-3500 rpm for 10-20 min. The two filtrates were collected and combined. The filtrate was concentrated, vacuum dried, pulverized, and sieved to obtain mangosteen peel extract.

[0011] The preferred feed additives mentioned above include 35 parts mangosteen peel extract, 30 parts white clover fruit extract, 15 parts ginger extract, 10 parts licorice extract, and 10 parts astragalus extract.

[0012] The scope of protection of this invention also includes:

[0013] Application of the above-mentioned feed additives in the preparation of feed additives for pregnant sows;

[0014] The application of the above-mentioned feed additives in the preparation of feed additives that shorten the farrowing process of sows;

[0015] The above-mentioned feed additives are used in the preparation of feed additives that improve the homeostasis of glucose metabolism in sows.

[0016] In the above-described applications, preferably, the feed additive is suitable for pig feed, and the addition amount in pig feed is 100-400 g / t. Compared with the prior art, the present invention has the following advantages:

[0017] This invention is the first to discover that mangosteen peel extract can be used as a feed additive, which can effectively shorten the birthing time of pregnant sows, enhance the body's immunity, and improve the reproductive performance of sows.

[0018] This invention provides a feed additive prepared by compounding mangosteen peel extract with white clover fruit extract, licorice extract, ginger extract, and astragalus extract. This additive has multiple benefits: ① it can effectively shorten the farrowing time of pregnant sows; ② it can enhance the immunity of pregnant sows; ③ it can improve the reproductive performance of sows; ④ it can improve the homeostasis of glucose metabolism in sows, thus greatly improving the production efficiency of pig farms. Specific Implementation

[0019] The present invention will be further described below with reference to specific embodiments, but the present invention is not limited to the embodiments. Unless otherwise specified, the technical solutions described in the present invention are conventional solutions in the art; the reagents or materials described, unless otherwise specified, are all from commercial sources.

[0020] Example 1:

[0021] Mangosteen peel extract was prepared by the following method:

[0022] (1) Dry the mangosteen peel in an oven at 100°C for 30 minutes, take it out, crush it, and pass it through a 60-mesh sieve to obtain dried mangosteen peel powder.

[0023] (2) Mix mangosteen peel powder with pure water at a ratio of 1:30 (g / mL), sonicate for 10 min, and centrifuge at 3000 r / min for 15 min to separate the solid and liquid phases. Remove the filtrate. Add the filter residue and 60% ethanol solution at a ratio of 1:20 (g / mL) to an electric pulse-ultrasonic extraction tank. Extract for 30 min at an electric field strength of 7 kV / cm, a pulse frequency of 500 Hz, an ultrasonic frequency of 10 kHz, and a system temperature of 40℃. Centrifuge at 3000 r / min for 15 min, collect the supernatant, and add the filter residue to 60% ethanol solution at a ratio of 1:25 (g / mL) to an ultrasonic extraction tank. Extract for 20 min, centrifuge at 3000 r / min for 15 min, collect and combine the two filtrates.

[0024] (3) The filtrate was concentrated under reduced pressure at 50°C, and the concentrated extract was vacuum dried to obtain dried mangosteen peel extract, which was used in the following examples.

[0025] Example 2:

[0026] The target sites of the extracts from traditional Chinese medicines vary depending on the extraction method. The applicant has used a large number of different extraction methods to screen the most suitable extraction method for this invention. The most conventional method is used as an example for comparison and explanation below.

[0027] Mangosteen peel extract was prepared by the following method (control group):

[0028] (1) Dry the mangosteen peel in an oven at 100°C for 30 minutes, take it out, crush it, and pass it through a 60-mesh sieve to obtain dried mangosteen peel powder.

[0029] (2) Mix mangosteen peel powder with 60% ethanol solution at a material-to-liquid ratio of 1:30 (g / mL), and microwave extract for 40s at 400W radiation power. Repeat the extraction three times, with a 10s interval between each extraction, and replenish the evaporated ethanol solution. Centrifuge the solid-liquid system at 4000 rpm for 20 min, and separate the supernatant to obtain mangosteen peel extract.

[0030] (3) Mangosteen peel extract was obtained by spray drying.

[0031] Example 3:

[0032] Application of mangosteen peel extract in the preparation of feed additives:

[0033] 1. Laboratory animals and experimental design

[0034] Seventy hundred multiparous sows of similar weight and body condition (3-4 parities) and gestation period (60 days) with normal reproductive history were selected. These sows were randomly divided into a control group (fed a basal diet) and six experimental groups (group 1, group 2, and group 3 were fed the same diet as the control group, supplemented with 200g / t, 300g / t, and 400g / t of mangosteen peel extract as described in Example 1; group 4, group 5, and group 6 were fed the same diet as the control group, supplemented with 200g / t, 300g / t, and 400g / t of mangosteen peel extract as described in Example 2). Each group consisted of 100 sows, with five replicates of 20 sows each. The experiment began at 60 days of gestation and lasted until farrowing, a period of 55 days. All sows maintained the same breeding method, feeding management, and immunization program. During gestation, they were fed twice daily with free access to water. 24-hour monitoring was conducted on the day of farrowing to accurately record the birth time of the first piglet, the birth time of the last piglet, and the time of placental expulsion. Detection indicators: (1) Sow reproductive performance: total number of piglets born, number of live piglets, number of weak piglets born, birth litter weight, and 21-day weaning litter weight; (2) Farrowing time: farrowing time, average farrowing interval, and placental expulsion time; (3) Immune performance: serum IgA, IgG, and IgM levels; (4) Placental glucose metabolites: lactic acid and glucose levels.

[0035] Data Statistical Analysis

[0036] The experimental data were statistically analyzed using SPSS 19.0 statistical software, and the results are shown in the table below.

[0037] Table 1 Reproductive performance of pregnant sows

[0038] project control group Experimental group 1 Experimental group 2 Experimental group 3 Experimental group 4 Experimental group 5 Experimental group 6 Total number of piglets born 11.12±0.53 11.67±0.34 11.58±0.34 11.63±0.54 11.17±0.38 11.06±0.46 11.12±0.65 Live births 10.05±0.23 11.19±0.27 11.06±0.37 11.14±0.48 10.21±0.35 9.98±0.43 10.07±0.42 Number of weak pups 0.53±0.12 0.43±0.09 0.45±0.14 0.41±0.08 0.49±0.14 0.48±0.16 0.47±0.18 stillbirths 1.07±0.21 0.48±0.19 0.52±0.32 0.49±0.21 0.96±0.27 1.08±0.34 1.05±0.36 Newborn 1.29±0.03 1.38±0.28 1.39±0.17 1.41±0.25 1.30±0.14 1.27±0.13 1.29±0.21 Newborn litter weight 13.26±1.23 14.36±1.32 14.39±1.42 14.44±1.39 13.85±1.16 13.12±1.26 13.07±1.36

[0039] As shown in Table 1, the total number of piglets born, the number of live piglets, and the litter weight of sows in experimental groups 1-3 all increased significantly compared to the control group. However, the number of weak piglets born in experimental groups 1-3 did not change significantly compared to the control group, while the number of stillbirths in experimental groups 1-3 decreased significantly compared to the control group. This indicates that experimental groups 1-3 can all improve the reproductive performance of sows, with experimental group 3 showing the best effect. Experimental groups 4-6 had no significant effect on the reproductive performance of sows. This demonstrates that the mangosteen peel extract obtained using the extraction method described in Example 1 can effectively enhance the reproductive performance of sows.

[0040] Table 2. Duration of pregnancy and labor

[0041]

[0042] As shown in Table 2, adding experimental groups 1-3 to the sow diet resulted in a certain or significant decrease in both farrowing time and average farrowing time, while the placental expulsion time remained largely unchanged. This indicates that experimental groups 1-3 all effectively shortened the sow's farrowing time, with experimental group 3 showing the best effect. Experimental groups 4-6 showed a slight decrease in farrowing time compared to the control group, but the effect was not significant. This demonstrates that the extraction method used in Example 1 can effectively shorten the sow's farrowing time.

[0043] Table 3 Immune performance indicators of pregnant sows

[0044] Immune indicators control group Experimental group 1 Experimental group 2 Experimental group 3 Experimental group 4 Experimental group 5 Experimental group 6 IgA (g / L) 0.18±0.07 0.24±0.09 0.24±0.12 0.27±0.07 0.19±0.13 0.20±0.14 0.21±0.15 IgG (g / L) 5.12±1.09 5.37±1.37 5.75±0.96 6.23±1.85 5.22±0.64 5.23±0.98 5.26±0.36 IgM (g / L) 0.46±0.09 0.67±0.18 0.73±0.24 0.85±0.16 0.50±0.13 0.51±0.14 0.54±0.26

[0045] As shown in Table 3, the addition of experimental groups 1-3 to the sow diet resulted in a certain or significant increase in the levels of globulins IgA, IgG, and IgM compared to the control group. This indicates that experimental groups 1-3 can all enhance the body's immunity, with experimental group 3 showing the best effect. Experimental groups 4-6 slightly improved the immune performance of sows, but the effect was not significant. This demonstrates that the extraction method used in Example 1 can improve the immune performance of sows.

[0046] Table 4. Content of placental glucose metabolites

[0047] control group Experimental group 1 Experimental group 2 Experimental group 3 Experimental group 4 Experimental group 5 Experimental group 6 Lactic acid (μmol / g) 6.28±0.56 6.05±0.95 6.01±0.76 5.68±0.95 6.24±0.97 6.34±0.67 6.19±0.78 Glucose (μmol / g) 9.86±1.35 10.26±0.98 11.26±1.74 11.67±1.24 9.75±1.24 9.83±0.72 9.72±1.01

[0048] As shown in Table 4, after adding experimental groups 1-3 to the sow diet, the glucose content in the placenta increased to a certain extent or significantly compared with the control group, while the lactic acid content decreased significantly compared with the control group. This indicates that experimental groups 1-3 can all improve the glucose homeostasis of sows, with experimental group 3 showing the best effect. Experimental groups 4-6 had no significant effect on the glucose metabolism of sows. This shows that the extraction method used in Example 1 can improve the glucose homeostasis of sows.

[0049] The mangosteen peel extracts described below were all extracted using the method described in Example 1.

[0050] Example 4 (Control Group):

[0051] A plant extract feed additive for improving prolonged labor in pregnant sows includes: 30 parts mangosteen peel extract, 25 parts chuanxiong extract, 20 parts angelica extract, 15 parts licorice extract, and 10 parts astragalus extract.

[0052] In this embodiment, the feed additive prepared is added to the sow feed at a rate of 100 g / t.

[0053] Example 5 (Control Group):

[0054] A plant extract feed additive for improving prolonged labor in pregnant sows includes: 30 parts mangosteen peel extract, 25 parts motherwort extract, 20 parts ginger extract, 15 parts salvia miltiorrhiza extract, and 10 parts astragalus extract.

[0055] In this embodiment, the feed additive prepared is added to the sow feed at a rate of 100 g / t.

[0056] Example 6:

[0057] A plant extract feed additive for improving prolonged labor in pregnant sows includes: 30 parts mangosteen peel extract, 25 parts white flower vine fruit extract, 20 parts ginger extract, 15 parts licorice extract, and 10 parts astragalus extract.

[0058] The preparation method of the extract of white flower vine fruit is as follows:

[0059] (1) Dry the fruit of *Sedum aizoon* in an oven at 100°C for 40 minutes, remove and crush, and pass through a 60-mesh sieve to obtain dried *Sedum aizoon* fruit powder. (2) Add the *Sedum aizoon* fruit powder and 70% ethanol solution to an ultrasonic extraction tank at a ratio of 1:30 (g / mL) and extract at 60°C for 30 minutes. Filter under reduced pressure and centrifuge the filtrate at 3000 r / min for 30 minutes. Take the supernatant and add the residue to a 70% ethanol solution at a ratio of 1:25 (g / mL) and extract in an ultrasonic extraction tank for 30 minutes. Collect and combine the two filtrates.

[0060] (3) The filtrate was concentrated, vacuum dried and then pulverized through a 60-mesh sieve to obtain the extract of white flower vine fruit. This method was used in this embodiment and the following embodiments.

[0061] In this embodiment, the feed additive prepared is added to the sow feed at a rate of 100 g / t.

[0062] Example 7:

[0063] A plant extract feed additive for improving prolonged labor in pregnant sows, comprising: 30 parts mangosteen peel extract, 30 parts white flower vine fruit extract, 20 parts ginger extract, 10 parts licorice extract, and 10 parts astragalus extract.

[0064] The feed additive prepared in this embodiment is added to pig feed at a rate of 200g / t.

[0065] Example 8:

[0066] A plant extract feed additive for improving prolonged labor in pregnant sows, comprising: 35 parts mangosteen peel extract, 30 parts white flower vine fruit extract, 15 parts ginger extract, 10 parts licorice extract, and 10 parts astragalus extract.

[0067] The feed additive prepared in this embodiment is added to pig feed at a rate of 300 g / t.

[0068] Example 9:

[0069] A plant extract feed additive for improving prolonged labor in pregnant sows, comprising: 40 parts mangosteen peel extract, 20 parts white flower vine fruit extract, 20 parts ginger extract, 10 parts licorice extract, and 10 parts astragalus extract.

[0070] The feed additive prepared in this embodiment is added to pig feed at a rate of 400 g / t.

[0071] Example 10:

[0072] Application of feed additives obtained by compounding mangosteen peel with other components in the preparation of pig feed additives:

[0073] Laboratory animals and experimental design

[0074] Seven hundred multiparous sows of similar weight and body condition (3-4 parities) with normal reproductive history and gestation periods of 60 days were selected. These sows were randomly divided into a control group (fed a basal diet) and six example groups (fed with additives prepared according to Examples 4-9, respectively). Each group consisted of 100 sows, with five replicates of 20 sows per replicate. The experiment began at 60 days of gestation and lasted until farrowing, a period of 55 days. All sows maintained consistent breeding methods, feeding management, and immunization programs. During gestation, they were fed twice daily with free access to water. Monitoring was conducted 24 hours after farrowing, with precise recording of the birth times of the first and last piglets, as well as the time of placental expulsion. Detection indicators: (1) Sow reproductive performance: total number of piglets born, number of live piglets, number of weak piglets born, birth litter weight, number of stillborn piglets; (2) Labor time: farrowing time, average farrowing interval, placental expulsion time; (3) Immune performance: serum IgA, IgG, IgM content; (4) Placental sugar metabolites: lactic acid, glucose content.

[0075] Data Statistical Analysis

[0076] The experimental data were statistically analyzed using SPSS 19.0 statistical software, and the results are shown in the table below.

[0077] Table 5 Farrowing Performance Indicators of Pregnant Sows

[0078] project control group Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Total number of piglets born 11.05±0.85 11.18±0.35 11.17±0.46 12.38±0.56 12.46±0.47 12.52±0.32 12.43±0.23 Live births 10.11±0.26 10.21±0.29 10.16±0.18 11.81±0.34 11.91±0.47 12.04±0.32 11.84±0.43 Number of weak pups 0.39±0.04 0.34±0.01 0.33±0.02 0.34±0.02 0.31±0.03 0.28±0.02 0.30±0.02 stillbirths 0.94±0.26 0.97±0.23 1.01±0.17 0.57±0.24 0.55±0.17 0.48±0.22 0.59±0.35 Newborn 1.27±0.27 1.32±0.27 1.31±0.24 1.34±0.31 1.35±0.28 1.47±0.21 1.45±0.36 Newborn litter weight 13.51±1.15 13.64±1.26 13.59±1.21 14.23±1.42 15.27±1.54 16.08±1.64 15.74±1.43

[0079] As shown in Table 5, Examples 4 and 5 had a certain improving effect on the reproductive performance of sows, but the effect was not significant. In Examples 6-9, the total number of piglets born, the number of live piglets born, and the litter weight at birth all showed a significant increase compared to the control group. However, the number of weak piglets born in Examples 6-9 showed a significant decrease compared to the control group. This indicates that Examples 6-9 can all improve the reproductive performance of pregnant sows, with Example 8 showing the best effect. This demonstrates that the feed additive is not concentration-dependent.

[0080] Table 6. Duration of pregnancy and labor

[0081]

[0082] As shown in Table 6, although Examples 4 and 5 did not significantly shorten the sow's farrowing time compared to the control group, Examples 6-9 showed a significant decrease in both the farrowing time and the average farrowing time, while the placental expulsion time remained largely unchanged. This indicates that Examples 6-9 can all shorten the sow's farrowing time, with Example 8 showing the best effect.

[0083] Table 7 Immune Performance Indicators of Lactating Sows

[0084] Immune indicators control group Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 IgA (g / L) 0.21±0.02 0.23±0.01 0.22±0.01 0.28±0.01 0.31±0.02 0.37±0.01 0.34±0.02 IgG (g / L) 5.45±1.02 5.65±0.73 5.59±0.96 6.96±0.98 6.13±1.15 7.42±1.05 7.29±0.68 IgM (g / L) 0.54±0.13 0.56±0.12 0.59±0.08 0.84±0.15 0.89±0.08 0.98±0.17 0.95±0.63

[0085] As shown in Table 7, Examples 4 and 5 had no significant effect on the immune performance of sows, but showed a trend of improvement. After adding Examples 6-9 to the sow diet, the levels of globulin IgA, IgG, and IgM all increased to a certain extent or significantly compared to the control group. This indicates that Examples 6-9 can all improve the body's immunity, with Example 8 showing the best effect.

[0086] Table 8. Content of placental glycogen metabolites

[0087] Immune indicators control group Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Lactic acid (μmol / g) 6.38±0.95 6.23±1.02 6.18±1.17 4.96±0.85 4.86±0.97 4.18±0.83 4.81±0.75 Glucose (μmol / g) 10.65±1.04 10.15±0.85 9.98±0.96 12.26±0.92 12.03±1.01 13.85±1.14 13.26±0.94

[0088] As shown in Table 8, Examples 4 and 5 had no significant effect on glucose metabolism in sows. However, after adding Examples 6-9 to the sow diet, the glucose content in the placenta increased to a certain extent or significantly compared to the control group, while the lactic acid content decreased significantly. This indicates that Examples 6-9 can all improve glucose homeostasis in sows, with Example 8 showing the best effect.

[0089] Based on the above experiments, it can be found that mangosteen peel extract, extracted according to the method described in Example 1 of this invention, can improve the reproductive performance of sows, shorten the farrowing process, enhance the body's immunity, and improve the homeostasis of glucose metabolism in sows. Furthermore, the applicant has formulated a compound of the mangosteen peel extract. Although the effective content of the mangosteen peel extract is reduced in the compounded formulation, it further optimizes the above-mentioned indicators, indicating that the compounded products have a good synergistic effect.

[0090] The present invention has been described above through specific embodiments, but the present invention is not limited to these specific embodiments. Furthermore, some terminology used in this specification and claims is not restrictive, but merely for ease of description.

Claims

1. A plant extract feed additive for improving prolonged labor in pregnant sows, comprising: Mangosteen peel extract 30-40 parts, white flower vine fruit extract 20-30 parts, ginger extract 15-20 parts, licorice extract 10-15 parts, astragalus extract 10 parts, by weight. The preparation method of the mangosteen peel extract includes: mixing mangosteen peel powder with pure water at a material-to-liquid ratio of 1g:20-40ml, ultrasonicating for 10-20 min, centrifuging at 2500-3500 r / min for 15-30 min to separate the solid and liquid phases, and removing the filtrate; adding the filter residue and 60-80% ethanol solution at a material-to-liquid ratio of 1g:20-40ml into an electric pulse-ultrasonic extraction cell, with an electric field strength of 6-8 kV / cm, a pulse frequency of 400-600 Hz, an ultrasonic frequency of 9-11 kHz, and a system temperature of 38-42℃ for 20-50 min, centrifuging at 2500-3500 r / min for 10-20 min, collecting the supernatant, and adding the filter residue back into a 60-80% ethanol solution at a material-to-liquid ratio of 1g:25-40ml into an ultrasonic extraction tank for 20-40 min. Centrifuge at 2500-3500 r / min for 10-20 min, collect and combine the two filtrates; concentrate the filtrate, vacuum dry, pulverize and sieve to obtain mangosteen peel extract.

2. The feed additive according to claim 1, characterized in that, include: 35 parts of mangosteen peel extract, 30 parts of white flower vine fruit extract, 15 parts of ginger extract, 10 parts of licorice extract, and 10 parts of astragalus extract.

3. The use of the feed additive according to claim 1 in the preparation of feed additives that shorten the farrowing process of sows.

4. The use of the feed additive according to claim 1 in the preparation of feed additives that improve the homeostasis of glucose metabolism in sows.

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