Nicotine composition pouches and methods of making the same

Abstract

The present application relates to a kind of nicotine composition sachet and its preparation method.Nicotine composition sachet includes nicotine composition and the non-woven fabric sachet for packaging the nicotine composition, the nicotine composition includes nicotine, sugar alcohol, pH regulator, filler, purified water, adhesive, humectant, flavoring agent and dispersing agent, the humidity of the nicotine composition sachet for increasing the nicotine composition humidity is 30~50%.The particle size of the nicotine composition before packaging is ≤500 microns, the humidity is 10%‑30%, and the carl index of bulk density is ≤20%.The preparation method provided by the present application is simple, can reduce the cost of preparation equipment, and the loading deviation is small, the operation is simple, the content is uniform, provides a kind of nicotine composition sachet with high humidity, good fluidity and low preparation cost.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of nicotine, in particular to a nicotine composition pouch and a preparation method thereof. BACKGROUND

[0002] Nicotine pouches as a kind of important product in smokeless tobacco, using oral tobacco reduces harmful substances generated by tobacco burning or pyrolysis. At the same time, oral tobacco can be used in places where smoking is prohibited, such as indoors, on airplanes, etc., to meet the physiological needs of consumers to intake nicotine.

[0003] The common oral tobacco is currently mixed by particles or powders, which can be divided into low-humidity products with humidity less than 10%, medium-humidity products with humidity between 10% and 30%, and high-humidity products with humidity between 30% and 50%. In particular in Europe, the market share of high-humidity products is more than 70%. High-humidity products have the characteristics of fast onset and strong throat impact, but due to high moisture, the flowability of high-humidity products is extremely poor when the particles are packaged, resulting in uneven content of finished products due to large loading, and the packaging process is not smooth and the feeding pipe is often blocked, resulting in low production efficiency.

[0004] In the patent with publication number CN114304712A, a liquid high-load nicotine oral product particle and a preparation method thereof are described: a high-viscosity adhesive, starch, and sugar alcohol and other materials are used together with nicotine, humectants, fiber materials, purified water, preservatives, flavorings, salt flavorings, pH adjusters, etc. to make particles with a particle size of 0.35mm-1mm to increase flowability, and the humidity is more than 40%. However, this method uses too many materials with high viscosity (such as propylene glycol, glycerol, starch, gum arabic, etc.), and the particle size is too large, which can easily cause particle adhesion and poor flowability.

[0005] In the patent with publication number EP4162927A1, the nicotine pouch composition is described: the sugar alcohol is at least 10% by weight of the composition; the water-insoluble fiber is at least 5-50% by weight of the composition; the water is at least 15-65% by weight of the composition; and the nicotine is used in an amount of 0.1-5% by weight of the composition; and the bulk density of the composition is at most 0.8g / L, wherein the weight ratio of water to water-insoluble fiber is not more than 3.0. This method can maintain high humidity while ensuring a certain flowability, but the particle size and bulk density are not described, and nicotine combined with resin and special particle packaging equipment are required.

[0006] The high-humidity nicotine pouches in the prior art usually use compressed air as the material power source to solve the problem of poor product flowability, and such structure has poor stability and the content is also lost due to the air source, and such equipment is usually a single-column machine, and the production capacity is low, and the high-efficiency production and product quality in the high-humidity nicotine pouches cannot be balanced.

[0007] Therefore, the prior art needs to be improved. SUMMARY

[0008] The high-humidity nicotine pouches in the prior art usually use expensive equipment to solve the problem of poor product flowability, and the high-efficiency production and product quality in the high-humidity nicotine pouches cannot be balanced, and therefore, the present application provides a nicotine composition pouch and a preparation method thereof to solve the above problems.

[0009] To achieve the above-mentioned purpose, in a first aspect, the present application provides a nicotine composition pouch, comprising a nicotine composition and a non-woven fabric pouch for packaging the nicotine composition, the nicotine composition comprising nicotine, sugar alcohol, pH regulator, filler, purified water, adhesive, humectant, flavoring agent and dispersing agent, the nicotine composition pouch further comprising a coating liquid for increasing the humidity of the nicotine composition, and the humidity of the nicotine composition pouch is 30-50%.

[0010] In an implementation manner, the coating liquid comprises one or more combinations of purified water, flavoring agent, sweetener, humectant, cooling agent and nicotine.

[0011] In an implementation manner, the nicotine composition comprises the following raw materials in parts by weight: nicotine 1-20 parts, sugar alcohol 5-20 parts, pH regulator 1-10 parts, filler 20-60 parts, purified water 5-30 parts, adhesive 1-5 parts, humectant 1-8 parts, flavoring agent 2-10 parts and dispersing agent 1-10 parts.

[0012] In an implementation manner, the particle size of the nicotine composition before packaging is ≤500 microns, the humidity is 10%-30%, and the Karl index of the bulk density is ≤20%.

[0013] In an implementation, the nicotine includes any one or combination of synthetic nicotine, natural nicotine, nicotine free base, nicotine-ion exchange resin combination, nicotine inclusion complex, and non-covalently bound nicotine, the nicotine-ion exchange resin combination includes any one or combination of nicotine lactate, nicotine malate, nicotine salicylate, nicotine resin complex, nicotine cyclodextrin inclusion complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, and nicotine benzoate.

[0014] In an implementation, the sugar alcohol is a polyol having two or more hydroxyl groups used as any one of thickening agent, binding agent, sweetener, and stabilizer, the polyol includes any one or combination of propylene glycol, xylitol, maltitol, mannitol, erythritol, isomalt, and lactitol.

[0015] In an implementation, the pH adjuster includes one or combination of sodium carbonate, sodium bicarbonate, potassium carbonate, magnesium carbonate, potassium bicarbonate, tromethamine, and phosphate buffer.

[0016] In an implementation, the filler is at least one water-insoluble fiber, the water-insoluble fiber includes one or combination of wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, cassia fiber, powdered cellulose, and microcrystalline cellulose, the water-insoluble fiber having a water-binding capacity of 200% or more.

[0017] In an implementation, the binding agent includes one or combination of natural plant gum, animal gum, polyvinyl alcohol, polyvinyl pyrrolidone, cellulose derivative, povidone, sodium alginate, and gum arabic, the cellulose derivative includes one or combination of microcrystalline cellulose, microcrystalline cellulose / sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and methyl cellulose.

[0018] In an implementation, the humectant includes one or combination of 1,2-propanediol, glycerin, honey, grape syrup, and maltitol sugar.

[0019] In one implementation, the flavoring agent includes one or a combination of bergamot, eucalyptus, citrus, lemon, peppermint, mint, menthol, licorice, wintergreen, tobacco, coffee, vanilla, lime, apple, peach, mango, cherry, blueberry, strawberry, cola, cinnamon, cassia, and watermelon.

[0020] In one implementation, the dispersing agent is a surfactant having lipophilicity and / or hydrophilicity in a molecule, the dispersing agent includes any one of fatty acid, fatty amide, ester, paraffin, metal soap, and low molecular wax, the ester includes any one of stearyl amide, vinyl bis stearyl amide, glyceryl monostearate, glyceryl tristearate, and medium chain fatty acid; the paraffin includes any one of paraffin, liquid paraffin, and microcrystalline paraffin; the metal soap includes any one of barium stearate, zinc stearate, calcium stearate, cadmium stearate, magnesium stearate, and copper stearate; the low molecular wax includes any one of homopolymer, oxidized homopolymer, ethylene-propylene acid copolymer, ethylene-vinyl acetate copolymer, low molecular ionomer, polyethylene wax, oxidized polyethylene wax, and polyethylene glycol.

[0021] In one implementation, the sweetening agent is a synthetic and / or natural extracted sweetening substance, the sweetening agent includes one or a combination of aspartame, acesulfame potassium, cyclamate, saccharin, sodium saccharin, sucralose, neotame, sodium cyclamate, alitame, stevia, glycyrrhiza, disodium glycyrrhizinate, tripotassium and trisodium glycyrrhizinate, glucose, fructose, sucrose, maltose, starch sugar, and lactose, sorbitol, maltitol, isomalt, palatinose, xylitol, lactitol, mannitol, erythritol, and dextran.

[0022] In one implementation, the cooling agent includes one or a combination of menthol, WS-3, WS-23, WS-12, WS-5, WS-14, menthone glycerol acetal, 3-(L-menthoxy)-2-methyl-1,2-propanediol, 3-(1-methoxy)-2-methyl-1,2-propanediol, cis and trans p-menthyl-3,8-diol, 2,3-dihydroxymenthane, 3,3,5-trimethylcyclohexanone glycerol ketal, (1R,3R,4S)-3-menthyl 3,6-oxabicycloheptaneacetate, (1R,2S,5R)-menthyl methoxyacetate, (1R,2S,5R)-menthyl 3,6,9-trioxadecanoate, (1R,2S,5R)-menthyl (2-hydroxyethoxy)acetate, and (1R,2S,5R)-menthyl 11-hydroxy-3,6,9-trioxoundecanoate.

[0023] In an implementation, the nicotine composition can further include a preservative, which includes one or a combination of sorbic acid and its salts, dehydroacetic acid and sodium salts, propyl gallate, sodium diacetate, calcium propionate, and sodium / calcium lactate.

[0024] In a second aspect, the present application further provides a method for preparing a nicotine composition pouch, which includes the following specific steps:

[0025] S1, granulating the nicotine composition according to the above formulation amount to obtain a nicotine composition with a particle size of ≤500 microns, a humidity of 10-30%, and a Carr index of the bulk density of ≤20%;

[0026] S2, loading the nicotine composition into the non-woven fabric pouch;

[0027] S3, mixing the purified water, flavoring agent, sweetener, humectant, cooling agent, and nicotine according to the above formulation amount of the coating liquid to prepare a coating liquid;

[0028] S4, loading the non-woven fabric pouch containing the nicotine composition particles into a coating machine, and obtaining the nicotine composition pouch with a humidity of 30-50% after the coating liquid is sprayed.

[0029] In an implementation, in S1, specifically includes: first, adding the solid powders of nicotine, sugar alcohol, pH adjuster, and filler into a double-cone mixer for premixing, mixing for 5-10 minutes at a speed of 6 revolutions per minute, and then loading into a barrel after mixing; loading the obtained material into a wet granulator for granulation, starting the stirring paddle at a speed of 100-200 revolutions, and stirring for 3-5 hours, then starting the spraying mode; at the same time, weighing and adding the purified water, binder, humectant, flavoring agent, and dispersant into a slurry preparation tank for preparation, wherein the stirring speed is 100-1500 revolutions per minute, and the stirring time is 10-30 hours, the material is added into the wet granulator through a pump, and the addition is completed within 3-8 minutes, at the same time, starting the granulation mode, stirring for 5-10 minutes, and then stopping to take out the material; loading the obtained material into a granule packaging machine for granule packaging, setting the granule machine speed to 120 granules per minute, and obtaining the nicotine composition.

[0030] In an implementation, in S4, specifically includes: loading the non-woven fabric pouch containing the nicotine composition particles into a coating machine, setting the rotation speed of the coating machine to 5-10 revolutions per minute, and setting the spraying flow rate to 5-60 revolutions per minute, and then continuing to rotate the coating machine for 5-30 minutes after the coating liquid is sprayed to obtain the nicotine composition pouch.

[0031] Beneficial effects: the nicotine composition sachet and the preparation method thereof provided by the present application, the nicotine salt or the nicotine combination resin is uniformly dispersed in the solid by the dispersing agent to form the nicotine composition, so that the nicotine composition can be loaded into the non-woven fabric sachet by the conventional particle packaging machine, the preparation method is simple, the cost of the preparation equipment is reduced, the loading deviation is small, the operation is simple, and the content is uniform; in the coating liquid used for humidification, the components such as flavoring agent, sweetening agent, cooling agent and nicotine can be added according to the requirement, the humidity is ensured, and the product is flavored; in the preparation method, the coating machine can accurately control the humidification amount of each sachet, and meanwhile, the flavoring, sweetening and cooling can be added, the contradiction between efficient production and product quality is solved, and the nicotine composition sachet with high humidity, good fluidity, stable loading amount, uniform content and low preparation cost is provided. BRIEF DESCRIPTION OF DRAWINGS

[0032] Figure 1 is the step flow chart of the preparation method of the nicotine composition sachet provided by the present application;

[0033] The implementation, functional characteristics and advantages of the present application will be further described with reference to the drawings. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application will be further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the present application, and are not used to limit the present application. In addition, the description of the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" described below means that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms is not necessarily for the same embodiment or example. Moreover, the technical features involved in each embodiment of the present application can be combined with each other as long as there is no conflict.

[0035] The present application provides a nicotine composition sachet, which comprises a nicotine composition and a non-woven fabric sachet for packaging the nicotine composition, the nicotine composition comprises nicotine, sugar alcohol, pH regulator, filler, purified water, adhesive, humectant, flavoring agent and dispersing agent, the nicotine composition sachet further comprises a coating liquid for increasing the humidity of the nicotine composition, and the humidity of the nicotine composition sachet is 30-50%. The coating liquid comprises one or more combinations of purified water, flavoring agent, sweetening agent, humectant, cooling agent and nicotine. The particle size of the nicotine composition before packaging is ≤500 microns, the humidity is 10%-30%, and the Karl index of the bulk density is ≤20%.

[0036] Specifically, the nicotine composition comprises the following raw materials by weight: nicotine 1-20 parts, sugar alcohol 5-20 parts, pH adjuster 1-10 parts, filler 20-60 parts, purified water 5-30 parts, binder 1-5 parts, humectant 1-8 parts, flavoring agent 2-10 parts, and dispersing agent 1-10 parts.

[0037] Specifically, the nicotine includes any one or a combination of synthetic nicotine, natural nicotine, nicotine free base, nicotine-ion exchange resin combination, nicotine inclusion complex, and non-covalently bound nicotine, and the nicotine-ion exchange resin combination includes any one or a combination of nicotine lactate, nicotine malate, nicotine salicylate, nicotine resin complex, nicotine cyclodextrin inclusion complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, and nicotine benzoate.

[0038] Specifically, the sugar alcohol is a polyhydric alcohol containing two or more hydroxyl groups used as any one of a thickening agent, a binder, a sweetener, and a stabilizer, and the polyhydric alcohol includes any one or a combination of propylene glycol, xylitol, maltitol, mannitol, erythritol, isomalt, and lactitol.

[0039] Specifically, the pH adjuster includes one or a combination of sodium carbonate, sodium bicarbonate, potassium carbonate, magnesium carbonate, potassium bicarbonate, tromethamine, and phosphate buffer.

[0040] Specifically, the filler is at least one water-insoluble fiber, and the water-insoluble fiber includes one or a combination of wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, cassia fiber, powdered cellulose, and microcrystalline cellulose, and the water-insoluble fiber has a water-binding capacity of 200% or more.

[0041] Specifically, the binder includes one or a combination of natural plant gum, animal glue, polyvinyl alcohol, polyvinylpyrrolidone, cellulose derivative, povidone, sodium alginate, and gum arabic, and the cellulose derivative includes one or a combination of microcrystalline cellulose, microcrystalline cellulose / carboxymethylcellulose sodium, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and methyl cellulose.

[0042] Specifically, the humectant includes one or a combination of 1,2-propanediol, glycerol, honey, glucose syrup, and maltitol sugar.

[0043] Specifically, the flavoring agent includes one or a combination of bergamot essence, eucalyptus essence, citrus essence, lemon essence, peppermint essence, mint essence, menthol, licorice essence, wintergreen essence, tobacco essence, coffee essence, vanilla essence, lime essence, apple essence, peach essence, mango essence, cherry essence, blueberry essence, strawberry essence, cola essence, cinnamon essence, cassia essence, and watermelon essence.

[0044] Specifically, the dispersing agent is an interfacial agent having lipophilicity and / or hydrophilicity in a molecule, and includes any one of fatty acid, fatty amide, ester, paraffin, metal soap, and low molecular wax, the ester includes any one of stearyl amide, vinyl bis-stearyl amide, stearic acid monoglyceride, glycerin tristearate, and medium chain fatty acid; the paraffin includes any one of paraffin, liquid paraffin, and microcrystalline paraffin; the metal soap includes any one of barium stearate, zinc stearate, calcium stearate, cadmium stearate, magnesium stearate, and copper stearate; and the low molecular wax includes any one of homopolymer, oxidized homopolymer, ethylene-propylene acid copolymer, ethylene-vinyl acetate copolymer, low molecular ionomer, polyethylene wax, oxidized polyethylene wax, and polyethylene glycol.

[0045] Specifically, the sweetening agent is a synthetic and / or naturally extracted sweetening substance, and includes one or a combination of aspartame, acesulfame potassium, cyclamate, saccharin, sodium saccharin, sucralose, neotame, sodium cyclamate, alitame, stevia, glycyrrhiza, disodium glycyrrhizinate, tripotassium and trisodium glycyrrhizinate, glucose, fructose, sucrose, maltose, starch sugar, and lactose, sorbitol, maltitol, isomalt, palatinose, xylitol, lactitol, mannitol, erythritol, and dextran.

[0046] Specifically, the cooling agent includes one or a combination of menthol, WS-3, WS-23, WS-12, WS-5, WS-14, menthone glycerol acetal, (3-(L-menthoxy)-2-methyl-1,2-propanediol, 3-(1-methoxy)-2-methyl-1,2-propanediol, cis and trans p-menthyl-3,8-diol, 2,3-dihydroxymenthane, 3,3,5-trimethylcyclohexanone glycerol ketal, (1R,3R,4S)-3-menthyl 3,6-oxabicycloheptaneacetate, (1R,2S,5R)-menthyl methoxyacetate, (1R,2S,5R)-menthyl 3,6,9-trioxadecanoate, (1R,2S,5R)-menthyl (2-hydroxyethoxy)acetate, and (1R,2S,5R)-menthyl 11-hydroxy-3,6,9-trioxoundecanoate.

[0047] Specifically, the nicotine composition can further comprise a preservative, which includes one or a combination of sorbic acid and its salts, dehydroacetic acid and sodium salts, propyl gallate, sodium diacetate, calcium propionate, and sodium / calcium lactate.

[0048] Specifically referring to Figure 1 The application also provides a preparation method of the nicotine composition bag, which comprises the following specific steps:

[0049] S1, granulating the nicotine composition according to the formula amount of the nicotine composition, to obtain the nicotine composition with a particle size of ≤500 microns, a humidity of 10%-30%, and a Carr index of the bulk density of ≤20%;

[0050] S2, loading the nicotine composition into the non-woven fabric bag;

[0051] S3, mixing the purified water, flavoring agent, sweetening agent, humectant, cooling agent, and nicotine according to the formula amount of the coating liquid to prepare the coating liquid;

[0052] S4, loading the non-woven fabric bag containing the nicotine composition particles into a coating machine, and obtaining the nicotine composition bag with a humidity of 30-50% after spraying the coating liquid.

[0053] Specifically, in S1, the following steps are included: first, adding solid powders of nicotine, sugar alcohol, pH regulator, and filler into a double-cone mixer for premixing, mixing for 5-10 minutes at a speed of 6 revolutions per minute, and then loading into a barrel after mixing; then, loading the obtained material into a wet granulator for granulation, starting the stirring paddle at a speed of 100-200 revolutions, and stirring for 3-5 hours, and then starting the spraying mode; meanwhile, weighing and loading the purified water, binder, humectant, flavoring agent, and dispersing agent into a slurry preparation tank for preparation, wherein the stirring speed is 100-1500 revolutions per minute, and the stirring time is 10-30 hours, the material is added into the wet granulator through a pump, and the addition is completed within 3-8 minutes, and then the stirring is stopped for 5-10 minutes to take out the material; and then, loading the obtained material into a granule packaging machine for granule packaging, setting the granule machine speed at 120 granules per minute, and obtaining the nicotine composition.

[0054] Specifically, in S4, the following steps are included: loading the non-woven fabric bag containing the nicotine composition particles into a coating machine, setting the rotation speed of the coating machine at 5-10 revolutions per minute, and setting the spraying flow rate at 5-60 revolutions per minute, and then continuing to rotate the coating machine for 5-30 minutes after spraying the coating liquid to obtain the nicotine composition bag.

[0055] The application adopts a secondary humidification process to meet the demand for high-humidity products. The water content in the first process is controlled between 10-30%. The conventional 16-column screw divider can be used for filling, and the output is large and the metering is stable.

[0056] The following examples are provided to illustrate the technical solutions of the present application.

[0057] Example 1, preparation of a nicotine composition pouch with a humidity of 37%.

[0058] The required materials were weighed according to the formulation in Table 1.

[0059]

[0060] Table 1, nicotine composition formulation in Example 1

[0061] The materials in the formulation in Table 1 were prepared as follows:

[0062] S11, the nicotine salt, microcrystalline cellulose, sodium chloride, xylitol, pH adjuster, preservative and other solid powders were weighed according to the formulation and added to a double-cone mixer for premixing, mixed for 5 minutes at a speed of 6 revolutions per minute, and after mixing was completed, the mixture was loaded into a barrel.

[0063] S12, the purified water, medium-chain fatty acids, sodium alginate, flavoring, propylene glycol, glycerol and other materials were weighed according to the formulation and added to a slurry preparation tank for preparation, with a stirring speed of 120 revolutions and a stirring time of 10 minutes.

[0064] S13: the materials obtained in S11 were added to a wet granulator, the stirring paddle was started, and the stirring speed was 100 revolutions per minute; after 3 minutes of stirring, the slurry injection mode was started: the materials obtained in S12 were added to the wet granulator through a pump. The addition was completed within 3 minutes, and at the same time, the granulation was started, and the stirring was continued for 5 minutes. The machine was stopped, and the materials were removed, obtaining the nicotine composition.

[0065] S14: the nicotine composition obtained in S13 was placed in a granule packaging machine for granule packaging, and the filling speed of the granule packaging machine was set to 120 granules per minute. After granule packaging was completed, the nicotine composition pouch was obtained. The nicotine composition therein was tested, and then the next step, coating, was performed.

[0066] The test results of the obtained nicotine composition are shown in Table 2.

[0067]

[0068] Table 2, test results of the nicotine composition prepared according to the formulation in Example 1

[0069] S15: coating liquid preparation, purified water was weighed according to 22% of the total weight of the nicotine composition to prepare the coating liquid. The nicotine composition pouch was added to a coating machine, and the rotation speed of the coating machine was set to 5 revolutions per minute. After the coating liquid was added, the machine was rotated for another 10 minutes, obtaining a high-moisture product. The high-moisture nicotine composition pouch was tested. The results are shown in Table 3.

[0070]

[0071] Table 3: Test results of high-moisture nicotine composition pouches of Example 1

[0072] As can be seen from Example 1, the Carr index of the nicotine composition before humidification was less than 15%, indicating that the flowability of the nicotine composition was very good, and 90% of the particle sizes were ≤380 microns, the humidity was 15%, and there was no pipe blockage during particle packaging, the flow was smooth, and the total amount after good dispensing met the standard. Subsequently, the nicotine composition pouches were coated and humidified, and after the moisture content was increased by 22%, the weight of the contents increased by about 20%, the humidity reached 37%, and the Carr index increased to 22%, the particle size became larger, but the nicotine content did not change, indicating that the increase in moisture content caused the change in humidity, which caused the increase in the Carr index and the increase in the particle size, which was due to the increase in the viscosity of the particles after the increase in humidity, thereby reducing the flowability of the particles. Example 1 shows that the present application can well solve the problem of high-moisture product particle packaging.

[0073] Example 2: Preparation of nicotine composition pouches with a humidity of 45%.

[0074] The required materials were weighed according to the formula in Table 4.

[0075]

[0076] Table 4: Nicotine composition formula in Example 2

[0077] The materials in Table 4 were prepared according to the following method:

[0078] S21: Take the nicotine salt, microcrystalline cellulose, sodium chloride, xylitol, pH adjuster, preservative, etc. according to the formula, and add them to the double-cone mixer for premixing, mix for 5 minutes at a speed of 6 revolutions per minute, and after mixing is complete, load the barrel.

[0079] S22: Weigh the purified water, medium-chain fatty acids, sodium alginate, flavor, propylene glycol, glycerol, etc. according to the formula, and add them to the slurry preparation tank for preparation. The stirring speed is 120 revolutions, and the stirring time is 10 minutes.

[0080] S23: Add the materials obtained in S21 to the wet granulator, start the stirring paddle, and stir at a speed of 100 revolutions per minute. After 3 minutes of stirring, start the slurry spraying mode: add the materials obtained in S22 to the wet granulator through the pump. Add the materials within 3 minutes, and at the same time, start the granulation, and stir for 5 minutes. Stop the machine and take out the materials to obtain the nicotine composition.

[0081] S24: Put the nicotine composition of S23 into a granule packing machine for granule packing, and the filling speed of the granule packing machine is set to 120 granules / min. After the granule packing is completed, the nicotine composition sachet is obtained. The nicotine composition in the nicotine composition sachet is detected, and then the next step, i.e., coating, is performed.

[0082] The detection results of the nicotine composition prepared according to the formulation of Example 2 are shown in Table 5.

[0083]

[0084] Table 5, detection results of nicotine composition prepared according to the formulation of Example 2

[0085] S25: Coating liquid preparation, purified water is weighed according to 25% of the total weight of the nicotine composition to prepare the coating liquid. The nicotine composition sachet is added into a coating machine, and the rotating speed of the coating machine is set to 5 revolutions / min. After the coating liquid is added, the product is rotated for 10 min to obtain a high-moisture product. The high-moisture nicotine composition sachet is detected. The results are shown in Table 6.

[0086]

[0087] Table 6, detection results of high-moisture nicotine composition sachet of Example 2

[0088] As can be seen from Example 2, the Carr index of the nicotine composition before humidification is less than 15%, indicating that the flowability of the nicotine composition is very good, and 90% of the particle sizes are ≤425 microns, the humidity is 20%, and there is no pipe blockage during the granule packing, and the discharging is smooth, and the total amount detected after the discharging is good and meets the standard. Then, the nicotine composition sachet is coated and humidified, and after the moisture content is increased by 25%, the weight of the content is increased by about 25%, the humidity reaches 45%, and the Carr index is increased to 27%, and the particle size is increased, but the nicotine content does not change, indicating that the increase of the moisture content leads to the change of the humidity, and then the Carr index and the particle size are increased, which is due to the increase of the viscosity of the granule after the increase of the humidity, thereby the flowability of the granule is poor. Through Example 2, it is illustrated that even in the case of 45% high humidity, the present application can well solve the problem of granule packing of high-moisture products.

[0089] Example 3, preparation of nicotine composition sachet with a humidity of 50%.

[0090] The materials required are weighed according to the formulation in Table 7.

[0091]

[0092] Table 7, nicotine composition formulation in Example 3

[0093] The materials of the formulation in Table 7 are prepared by the following method:

[0094] S31: The nicotine salt, microcrystalline cellulose, sodium chloride, xylitol, pH regulator, preservative and other solid powders were weighed according to the formula, added to a double-cone mixer for premixing, mixed for 5 minutes at a speed of 6 revolutions per minute, and then loaded into a barrel after mixing was completed.

[0095] S32: The purified water, medium-chain fatty acids, sodium alginate, flavor, propylene glycol, glycerol and other materials were weighed according to the formula and added to a slurry preparation tank for preparation. The stirring speed was 120 revolutions, and the stirring time was 10 minutes.

[0096] S33: The material obtained in S31 was added to a wet granulator, the stirring paddle was started, and the stirring speed was 100 revolutions per minute. After 3 minutes of stirring, the slurry injection mode was started: the material obtained in S32 was added to the wet granulator through a pump. The addition was completed within 3 minutes, and the granulation was started at the same time. The stirring was continued for 5 minutes. The material was removed after the machine was stopped, and the nicotine composition was obtained.

[0097] S34: The nicotine composition obtained in S33 was placed in a granule packaging machine for granule packaging. The filling speed of the granule packaging machine was set to 120 granules per minute. After the granule packaging was completed, the nicotine composition pouches were obtained. The nicotine composition in the pouches was tested, and the next step, coating, was performed.

[0098] The test results of the nicotine composition prepared according to the formula in Example 3 are shown in Table 8.

[0099]

[0100] Table 8, test results of the nicotine composition prepared according to the formula in Example 3

[0101] S35: The coating liquid was prepared by weighing purified water to 25% of the total weight of the nicotine composition. The nicotine composition pouches were added to a coating machine, and the rotation speed of the coating machine was set to 5 revolutions per minute. After the coating liquid was added, the machine was rotated for another 10 minutes to obtain a high-moisture product. The high-moisture nicotine composition pouches were tested. The results are shown in Table 9.

[0102]

[0103] Table 9, test results of the high-moisture nicotine composition pouches prepared in Example 3

[0104] As can be seen from Example 3, the Carr index of the nicotine composition before humidification is 16%, indicating that the nicotine composition has good flowability, and 90% of the particle size is 500 microns, the humidity is 25%, and the pipe blocking phenomenon occurs less during particle packaging, and the discharge is still smooth, and the weight after good dispensing meets the standard. Subsequently, the nicotine composition bag is coated and humidified, and after the moisture is increased by 25%, the content weight is increased by about 25%, the humidity reaches 50%, and the Carr index is increased to 39%, the particle size is increased, but the nicotine content is not changed, which indicates that the increase of moisture leads to the change of humidity, and the increase of the Carr index and the increase of the particle size, which is due to the increase of the viscosity of the particles after the increase of the humidity, thereby the flowability of the particles is poor. Through Example 3, it is shown that even in the case of 50% high humidity, the present application can well solve the problem of particle packaging of high-humidity products.

[0105] Example 4, stability study of 35% high-humidity product

[0106] Table 10 is the result of the 12-month stability study of the high-humidity nicotine composition bag of batch 20210725.

[0107]

[0108] Table 10, nicotine composition bag (humidity 37%) long-term stability experimental data summary

[0109] Batch number: 20210725

[0110] As can be seen from Example 4, the nicotine composition bag obtained by the present application can still maintain normal content and moisture after 12 months, meeting the quality requirements and having long-term stability.

[0111] In summary, the nicotine composition bag and the preparation method thereof provided by the present application, by dispersing the nicotine salt or the nicotine combination resin uniformly in the solid through the dispersing agent to form the nicotine composition, so that the nicotine composition can be loaded into the non-woven fabric bag through the conventional particle packaging machine, the preparation method is simple, the cost of the preparation equipment is reduced, the loading deviation is small, the operation is simple, the content is uniform; in the coating liquid for humidification, the flavoring agent, the sweetener, the cooling agent, the nicotine and other ingredients can be added according to the demand, the humidity is ensured at the same time, and the flavor of the product is increased; in the preparation method, the coating machine can accurately control the humidification amount of each bag, and at the same time, the flavor, sweetness and cooling can be increased, solving the contradiction between efficient production and product quality, and providing a nicotine composition bag with high humidity, good flowability, stable loading amount, uniform content and low preparation cost.

[0112] The above merely describes preferred embodiments of the present application, and is not intended to limit the patent scope of the present application, and any equivalent structure or equivalent process conversion made by using the content of the present application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A nicotine composition pouch, characterized in that: A nicotine composition and a non-woven fabric pouch for encapsulating the nicotine composition, wherein the nicotine composition comprises nicotine, a sugar alcohol, a pH adjuster, a filler, purified water, a binder, a humectant, a flavoring agent, and a dispersant. The nicotine composition pouch further comprises a coating liquid for increasing the humidity of the nicotine composition, and the humidity of the nicotine composition pouch is 30-50%. The method for preparing the nicotine composition pouch comprises the following steps: S1. Granulating the nicotine composition according to the formula to obtain a nicotine composition having a particle size of ≤500 μm, a humidity of 10%-30%, and a Carr's index of bulk density ≤20%; S2. putting the nicotine composition into the non-woven fabric pouch; S3. According to the formula of the coating solution, the purified water, flavoring agent, sweetener, moisturizing agent, cooling agent and nicotine are mixed to prepare a coating solution; S4. Adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, and after spraying the coating liquid, obtaining the nicotine composition pouch with a humidity of 30-50%.

2. The nicotine composition pouch according to claim 1, characterized in that The nicotine composition comprises the following raw materials in parts by weight: 1-20 parts of nicotine, 5-20 parts of sugar alcohol, 1-10 parts of pH regulator, 20-60 parts of filler, 5-30 parts of purified water, 1-5 parts of binder, 1-8 parts of moisturizer, 2-10 parts of flavoring agent and 1-10 parts of dispersant.

3. The nicotine composition pouch according to claim 1, wherein: The nicotine includes any one or a combination of synthetic nicotine and non-covalently bound nicotine.

4. The nicotine composition pouch according to claim 1, wherein: The sugar alcohol is a polyol containing two or more hydroxyl groups and is used as any one of a thickener, a binder, a sweetener and a stabilizer. The polyol includes any one of xylitol, maltitol, mannitol, erythritol, isomalt and lactitol or a combination thereof.

5. The nicotine composition pouch according to claim 1, wherein: The pH regulator includes one or a combination of sodium carbonate, sodium bicarbonate, potassium carbonate, magnesium carbonate, potassium bicarbonate, tromethamine and phosphate buffer.

6. The nicotine composition pouch according to claim 1, wherein: The filler is at least one water-insoluble fiber, and the water-insoluble fiber includes one or a combination of wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, bran fiber, bamboo fiber, pandan fiber and microcrystalline cellulose, and the water-insoluble fiber has a water binding capacity of more than 200%.

7. The nicotine composition pouch according to claim 1, wherein: The adhesive includes one or a combination of natural plant glue, animal glue, polyvinyl alcohol, polyvinyl pyrrolidone, cellulose derivatives, povidone and sodium alginate, and the cellulose derivative includes one or a combination of microcrystalline cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose and methyl cellulose.

8. The nicotine composition pouch according to claim 1, wherein: The moisturizing agent includes one or a combination of 1,2-propylene glycol, glycerol, honey, glucose syrup and maltitol sugar.

9. The nicotine composition pouch according to claim 1, wherein: The flavoring agent includes one or a combination of eucalyptus flavor, citrus flavor, mint flavor, licorice flavor, wintergreen flavor, coffee flavor, vanilla flavor, apple flavor, peach flavor, mango flavor, cherry flavor, blueberry flavor, strawberry flavor, cola flavor, cinnamon flavor, pandan flavor and watermelon flavor.

10. The nicotine composition pouch according to claim 1, wherein: The dispersant is a surfactant having lipophilicity and / or hydrophilicity in the molecule, and the dispersant includes any one of fatty acids, aliphatic amides, esters, paraffins, metal soaps and low molecular weight waxes. The esters include any one of stearamide, vinyl bisstearamide, stearic acid monoglyceride, tristearic acid glyceride and medium-chain fatty acids; the paraffins include any one of paraffin and microcrystalline paraffin; the metal soaps include any one of barium stearate, zinc stearate, calcium stearate, cadmium stearate, magnesium stearate and copper stearate.

11. The nicotine composition pouch according to claim 1, wherein: The sweetener is a sweetening substance artificially synthesized and / or naturally extracted, and includes one or a combination of aspartame, acesulfame potassium, cyclamate, saccharin, saccharin sodium, sucralose, neotame, stevioside, licorice, disodium glycyrrhizate, tripotassium glycyrrhizate, trisodium glycyrrhizate, glucose, fructose, sucrose, maltose, starch sugar and lactose, sorbitol, maltitol, isomalt, palatinol, xylitol, lactitol, mannitol, erythritol and dextran.

12. The nicotine composition pouch according to claim 1, wherein: The cooling agent includes one of menthol, WS-3, WS-23, WS-12, WS-5 or a combination thereof.

13. The nicotine composition pouch according to claim 1, wherein: The nicotine composition further includes a preservative, which includes one or a combination of sorbic acid and its salts, dehydroacetic acid and its sodium salts, parabens, sodium diacetate, calcium propionate, and sodium / calcium lactate.

14. A method for preparing the nicotine composition pouch according to claim 1, characterized in that: The specific steps include: S1. Granulating the nicotine composition according to the formula to obtain a nicotine composition having a particle size of ≤500 μm, a humidity of 10%-30%, and a Carr's index of bulk density ≤20%; S2. putting the nicotine composition into the non-woven fabric pouch; S3. According to the formula of the coating solution, the purified water, flavoring agent, sweetener, moisturizing agent, cooling agent and nicotine are mixed to prepare a coating solution; S4. Adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, and after spraying the coating liquid, obtaining the nicotine composition pouch with a humidity of 30-50%.

15. The method for preparing a nicotine composition pouch according to claim 14, wherein: In S1, the steps include: first, adding solid powders of nicotine, sugar alcohol, pH adjuster and filler to a double cone mixer for premixing, mixing for 5-10 minutes at a speed of 6 rpm, and then barreling after mixing; adding the resulting material to a wet granulator for granulation, turning on a stirring paddle and stirring at a speed of 100-200 rpm for 3-5 minutes, and then turning on a spraying mode; simultaneously, weighing purified water, a binder, a moisturizer, a flavoring agent and a dispersant, and adding them to a slurry preparation tank for preparation, wherein the stirring speed is 100-1500 rpm and the stirring time is 10-30 minutes, adding the material to the wet granulator via a pump, completing the filling within 3-8 minutes, turning on a granulation mode, stirring for 5-10 minutes, stopping the machine and removing the material; and placing the resulting material into a granule packaging machine for granule packaging, with the granule machine speed set at 120 granules / minute, to obtain the nicotine composition.

16. The method for preparing a nicotine composition pouch according to claim 14, wherein: S4 specifically includes: adding the non-woven fabric pouch containing the nicotine composition particles into a coating machine, setting the coating machine speed to 5-10 rpm and the spraying flow rate to 5-60 rpm; after spraying the coating liquid, the coating machine continues to rotate for 5-30 minutes to obtain the nicotine composition pouch.

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