Nitric oxide gas supply device

Abstract

The present application provides a nitric oxide gas supply method and device, and the specific steps of the gas supply method include: generating nitric oxide and obtaining data of the patient's respiratory cycle; calculating the gas phase threshold of the respiratory cycle based on the data of multiple patient respiratory cycles; comparing the current gas flow value with the gas phase threshold of the respiratory cycle to determine whether the respiratory cycle has entered the inhalation phase; when the patient enters the inhalation phase, providing the patient with a gas mixed with nitric oxide and air. During the patient's inhalation phase, the gas mixed with nitric oxide and air is delivered to ensure that the nitric oxide gas supply device is synchronized with the gas supply rhythm of the invasive ventilator to avoid false triggering of mechanical ventilation by the invasive ventilator. During the inhalation phase, a gas mixed with nitric oxide and air is provided to avoid providing nitric oxide in the expiratory phase and the nitric oxide remaining in the pipeline during the same period, to prevent nitric oxide from being converted into nitrogen dioxide, and to improve the safety of gas supply to patients.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a nitric oxide gas supply device. Background Art

[0002] Nitric oxide, also known as endothelial cell relaxing factor, can be produced by endothelial cells and act as a signal molecule to regulate the activities of other cells and improve the function of endothelial cells. Inhalation of a certain concentration of nitric oxide can selectively dilate pulmonary blood vessels, relax tracheal and bronchial smooth muscles, reduce pulmonary artery pressure, improve pulmonary blood flow ventilation ratio and oxygenation, and has the advantages of rapid efficacy, non-traumatic and high selectivity. It has not only been successfully used in the treatment of persistent hypoxemia and pulmonary hypertension in neonates, but has also been increasingly used in the treatment of acute respiratory distress syndrome, hypertension and some lung-related diseases in adults.

[0003] At present, when the nitric oxide gas supply system is connected to the invasive ventilator in clinical practice, the common solution is to directly connect the nitric oxide gas supply system to the gas supply system of the invasive ventilator. This will cause a large difference between the expected tidal volume and the actual tidal volume of the ventilator. The nitric oxide gas supply system will interfere with the gas supply rhythm of the invasive ventilator, resulting in incorrect rhythm feedback of the invasive ventilator. In addition, if nitric oxide gas is continuously provided during the expiratory phase, the concentration of nitric oxide in the ventilation circuit will be too high, and the residence time of nitric oxide will be long. Since nitric oxide is an unstable gas that is easily oxidized by oxygen, the probability of nitric oxide being converted into nitric dioxide is increased, and the actual concentration of nitric dioxide inhaled by the patient is increased. Nitric oxide is harmful to the human body, and excessive inhalation is not good for the patient's health. Summary of the invention

[0004] The technical problem to be solved by the present application is that the existing nitric oxide supply system is directly connected to the invasive ventilator, which causes the nitric oxide supply system to interfere with the gas supply rhythm of the invasive ventilator and affect the rhythm feedback error of the invasive ventilator. In addition, the continuous supply of nitric oxide in the expiratory phase can easily lead to an excessively high concentration of nitric oxide in the ventilation circuit, increasing the probability of nitric oxide being converted into nitrogen dioxide.

[0005] In order to solve the above problems, in order to solve the above technical problems or at least partially solve the above technical problems, the present application provides a nitric oxide supply device.

[0006] The present invention also discloses a nitric oxide gas supply device, which includes a gas production unit, a switching unit, a sensing unit, and a control unit;

[0007] The gas production unit is connected to the switching unit, the sensing unit is connected to the gas outlet of the patient's ventilator, and the control unit is respectively connected to the gas production unit, the switching unit, and the sensing unit;

[0008] The sensing unit is used to sense and record the change of flow in the ventilator, and the switching unit can switch the direction of nitric oxide gas output;

[0009] The sensing unit senses the change of the flow value in the gas path and feeds back the change to the control unit through an electrical signal. The control unit controls the output end of the switching unit based on the flow change information fed back by the sensing unit to determine whether it is in the inhalation phase and whether to output nitric oxide gas to the ventilator.

[0010] The nitric oxide gas supply device performs the following nitric oxide gas supply method:

[0011] Based on the respiratory cycle data in the ventilator, the gas phase threshold of the respiratory cycle is calculated; according to the respiratory cycle data in the ventilator, the flow fluctuation amplitude of the gas circuit is determined, and the peak-to-peak value of the gas circuit flow amplitude is obtained based on the flow fluctuation amplitude of the gas circuit, and the gas phase threshold of the respiratory cycle in the ventilator is obtained based on the peak-to-peak value of the flow amplitude;

[0012] The gas phase threshold of the respiratory cycle is compared with the change in the flow value in the gas circuit sensed by the sensing unit; the current gas circuit flow value sensed by the sensing unit is judged from the feedback electrical signal that the current gas circuit flow value changes from below the gas phase threshold of the respiratory cycle to above the gas phase threshold of the respiratory cycle, and the respiratory cycle in the ventilator is judged to be in the inhalation phase; the current gas circuit flow value sensed by the sensing unit is judged from the feedback electrical signal that the current gas circuit flow value changes from above the gas phase threshold of the respiratory cycle to below the gas phase threshold of the respiratory cycle, or the gas circuit flow value is always below the gas phase threshold of the respiratory cycle, and the respiratory cycle in the ventilator is judged to be in the expiratory phase.

[0013] Preferably, determining the flow fluctuation amplitude of the air circuit according to the respiratory cycle data in the ventilator includes: taking the mean and median of the respiratory cycle data in the ventilator, or filtering to obtain a stable flow fluctuation amplitude of the air circuit.

[0014] Preferably, it comprises a filtering unit and a purification unit, wherein one end of the filtering unit is connected to the switching unit and the other end is connected to the patient, and one end of the purification unit is connected to the switching unit and the other end is connected to the external environment.

[0015] Preferably, the purification unit is loaded with an absorbent for nitrides.

[0016] Preferably, the filtration unit uses either an adsorption method or a membrane separation method to remove impurities from the gas.

[0017] Preferably, the switching unit comprises a three-way solenoid valve, and the three-way solenoid valve is respectively connected to the gas production unit, the filtering unit and the purification unit.

[0018] Preferably, a gas concentration detection unit is included, the gas concentration detection unit is connected to the control unit, and the gas concentration detection unit is installed close to the patient.

[0019] Preferably, the sensing unit is a flow sensor or a pressure sensor.

[0020] Preferably, the sensing unit uses a pressure sensor to collect the gas pressure value in the gas path, and the sensing unit sends a pressure signal to the control unit, and the control unit determines whether the respiratory cycle is in the exhalation phase or the inspiration phase according to the pressure signal;

[0021] When the pressure value changes from a low pressure value to a high pressure value, the control unit determines that the breathing cycle in the ventilator is in an inspiratory phase;

[0022] When the pressure value changes from the high pressure value to the pressure value, the control unit determines that the breathing cycle in the ventilator is in the exhalation phase.

[0023] Preferably, a gas mixing unit is included, and the gas mixing unit is installed at the connection port between the patient and the ventilator pipeline, or on the ventilator worn on the patient.

[0024] The above technical solution provided by this application has the following advantages compared with the prior art:

[0025] The present application provides a nitric oxide gas supply device, which calculates the gas phase threshold of the respiratory cycle for the patient's respiratory cycle data, compares and judges whether the current patient's respiratory cycle has entered the inspiratory phase based on the gas phase threshold of the respiratory cycle and the current gas path flow value, and when entering the inspiratory phase, provides the patient with a gas mixed with nitric oxide and air to provide treatment to the patient. During the patient's inspiratory phase, the gas mixed with nitric oxide and air is delivered to ensure that the nitric oxide gas supply device and the gas supply rhythm of the invasive ventilator are synchronized to avoid false triggering of mechanical ventilation by the invasive ventilator. During the inspiratory phase, a gas mixed with nitric oxide and air is provided to avoid the provision of nitric oxide in the expiratory phase and the residual nitric oxide in the pipeline during the same period, to prevent nitric oxide from being converted into nitrogen dioxide, and to improve the safety of gas supply to patients.

[0026] In the gas supply device, the switching unit can switch the direction of nitric oxide gas output, the gas production unit provides nitric oxide gas, the sensing unit is used to sense and record the flow change in the ventilator, and the control unit controls the output end of the switching unit by the flow change information fed back by the sensing unit to determine whether it is in the inhalation phase and whether to output nitric oxide gas to the patient. The control unit can also control the start and stop of the gas production unit. The nitric oxide gas generated by the nitric oxide supply device is only delivered to the invasive ventilator gas supply branch during the patient's inhalation phase to ensure To ensure that the gas supply rhythm of the nitric oxide supply device is synchronized with that of the invasive ventilator to avoid false triggering of mechanical ventilation by the invasive ventilator, the nitric oxide supply device only provides nitric oxide gas to the gas delivery branch of the invasive ventilator during the patient's inhalation phase, thereby avoiding the provision of nitric oxide during the patient's expiratory phase and the residual nitric oxide in the airway tube, thereby preventing nitric oxide from being converted into nitrogen dioxide. In addition, the gas supply device only provides nitric oxide gas to the airway during the patient's inhalation phase and stops providing nitric oxide gas during the expiratory phase, thereby ensuring that the expiratory tidal volume monitored by the invasive ventilator is accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0028] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0029] Figure 1 A schematic diagram of a nitric oxide supply method provided in this application;

[0030] Figure 2 A schematic flow chart of step S2 of a nitric oxide supply method provided in the present application;

[0031] Figure 3 A schematic flow chart of step S3 of a nitric oxide supply method provided in the present application;

[0032] Figure 4 It is a waveform diagram of the gas flow value of the ventilator;

[0033] Figure 5 It is a waveform diagram of the gas circuit pressure value of the ventilator;

[0034] Figure 6 This is a schematic structural diagram of a nitric oxide gas supply device provided in this application.

[0035] Description of reference numerals:

[0036] 1. Nitric oxide gas supply device;

[0037] 11. Gas production unit; 12. Switching unit; 13. Sensing unit; 14. Control unit; 15. Filtering unit; 16. Purification unit; 17. Gas concentration detection unit; 18. Gas mixing unit;

[0038] 2. Ventilator. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solutions and advantages of this application clearer, the technical solutions in this application will be clearly and completely described below in conjunction with the drawings in this application. Obviously, the described embodiments are part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0040] First, see Figure 1 The present invention provides a method for supplying nitric oxide, the specific steps of which include:

[0041] Step S1: generating nitric oxide and acquiring data of the patient's breathing cycle;

[0042] Step S2: Calculating the gas phase threshold of the respiratory cycle based on the data of multiple patient respiratory cycles;

[0043] Step S3: Compare the current gas flow value with the gas phase threshold of the respiratory cycle to determine whether the respiratory cycle enters the inspiratory phase;

[0044] Step S4: When the patient enters the inhalation phase, a gas mixed with nitric oxide and air is provided to the patient.

[0045] Specifically, in step S1, the nitric oxide gas generating mechanism uses air under atmospheric pressure as a gas source and generates nitric oxide gas of the required concentration by pulse discharge. The ventilator and related mechanisms record the patient's respiratory cycle data. The patient's respiratory cycle data can facilitate subsequent judgment of whether the patient is in exhalation or inhalation, so as to facilitate the input of nitric oxide gas.

[0046] Specifically, in step S2, there is unstable data in the patient's respiratory cycle data, and it is necessary to collect stable respiratory cycle data to calculate the gas phase threshold of the respiratory cycle for subsequent comparison of the current airway flow value and the gas phase threshold of the respiratory cycle. Collecting stable respiratory cycle data can improve the accuracy of judging the respiratory cycle.

[0047] Specifically, in step S3, the flow rate of the current patient's respiratory airway is used to determine whether the patient is in the expiratory phase or the inspiratory phase, and the nitric oxide supply is synchronized with the ventilator's supply, so that the ventilator achieves human-machine synchronization and the ventilator detects tidal volume more accurately.

[0048] Specifically, in step S4, when it is determined that the patient has entered the inhalation phase, the nitric oxide gas is mixed with the air generated by the ventilator and then delivered to the patient for treatment.

[0049] Specifically, in the gas supply method, the gas phase threshold of the respiratory cycle is calculated for the patient's respiratory cycle data, and the gas phase threshold of the respiratory cycle is compared with the current gas path flow value to determine whether the current patient's respiratory cycle has entered the inspiratory phase. When entering the inspiratory phase, a gas mixed with nitric oxide and air is provided to the patient to provide treatment to the patient. During the patient's inspiratory phase, a gas mixed with nitric oxide and air is delivered to ensure that the nitric oxide gas supply device and the gas supply rhythm of the invasive ventilator are synchronized to avoid false triggering of mechanical ventilation by the invasive ventilator. During the inspiratory phase, a gas mixed with nitric oxide and air is provided to avoid providing nitric oxide in the expiratory phase and the residual nitric oxide in the pipeline during the same period, to prevent nitric oxide from being converted into nitrogen dioxide, and to improve the safety of gas supply to patients.

[0050] It is understandable that since long-term inhalation of nitrogen dioxide is harmful to the human body, it is necessary to prevent patients from inhaling nitrogen dioxide when connected to a ventilator. Nitrogen dioxide is generally easily produced in the ventilation duct during the patient's expiratory phase, causing the patient to inhale it during the inspiratory phase. When the patient enters the expiratory phase, nitric oxide is not directly mixed with the air and delivered to the patient. It is not until the patient enters the inspiratory phase that nitric oxide gas is mixed with the air and delivered to the patient. The current airway flow value is compared with the gas phase threshold of the respiratory cycle to determine whether the respiratory cycle is in the inspiratory phase. Only when it is in the inspiratory phase can nitric oxide be directly mixed with the air and delivered to the patient.

[0051] Nitric oxide can be supplied synchronously and adaptively according to the frequency of the invasive ventilator's gas supply, thereby improving the accuracy of the invasive ventilator's human-machine synchronization and the ventilator's tidal volume detection. In addition, it can also adapt to various populations and a variety of invasive ventilators, thereby improving the applicability of the method.

[0052] See also Figure 1 , before step S1, the following steps are also included:

[0053] Step S0: Determine whether the type of ventilator connected to the patient is an invasive ventilator. When the patient uses an invasive ventilator, execute the step of generating nitric oxide.

[0054] Specifically, ventilators are divided into invasive ventilators, non-invasive ventilators, oxygen concentrators, oxygen absorbers, etc. Non-invasive ventilators, oxygen concentrators, oxygen absorbers are open-circuit devices. Open-circuit devices do not have problems such as controlling respiratory rhythm, excessive airway pressure, and accumulation and variation of nitric oxide. The air circuit of invasive ventilators is non-open, and it is better to monitor the changes in flow or pressure. When the ventilator used by the patient uses an invasive ventilator, nitric oxide gas is generated and input into the invasive ventilator, while when the patient is connected to a non-invasive ventilator, nitric oxide gas is not input into the ventilator.

[0055] As an embodiment, a flow sensor or a pressure sensor is set in the air circuit to sense the change of flow or pressure in the air circuit. When the fluctuation of flow or pressure in the air circuit follows the law of breathing cycle and the amplitude exceeds a certain threshold (that is, the peak value of pressure or flow exceeds a certain value), it is an invasive ventilator, otherwise it is a non-invasive ventilator or other open device, and the threshold is input in advance by the operator.

[0056] See also Figure 1 , after step S3, the following steps are included:

[0057] Step S5: When the patient enters the exhalation phase, nitric oxide is output to the atmosphere.

[0058] Specifically, the patient enters the expiratory phase and is in the exhalation stage. In order to prevent nitric oxide from remaining in the airway and converting into nitrogen dioxide, it is necessary to avoid continuous input of nitric oxide during this stage. Due to the continuous generation of nitric oxide, it needs to be output to the atmospheric environment.

[0059] See also Figure 2 , step S2 specifically includes the following steps:

[0060] Step S21: determining the flow fluctuation amplitude of the gas circuit according to the data of multiple patient breathing cycles;

[0061] Step S22: Calculate the peak-to-peak value of the flow fluctuation amplitude according to the flow fluctuation amplitude of the gas path to obtain the peak-to-peak value of the flow amplitude;

[0062] Step S23: Calculate the inspiratory phase threshold based on the peak-to-peak value of the flow amplitude to obtain the gas phase threshold of the respiratory cycle.

[0063] Specifically, a stable airway flow fluctuation amplitude is obtained from the respiratory cycle data of multiple patients, the maximum and minimum values ​​of the airway flow fluctuation amplitude are collected, the peak-to-peak value of the flow amplitude is obtained, and the inspiratory phase threshold calculation formula is used to calculate to obtain the gas phase threshold of the respiratory cycle, that is, B=K*A, wherein B is the gas phase threshold of the respiratory cycle, K is the coefficient, and A is the peak-to-peak value of the flow amplitude. It can be understood that the inspiratory phase threshold is equal to the peak-to-peak value of the flow amplitude multiplied by the coefficient, wherein the coefficient is 0.1-0.4, and the flow amplitude requires multiple stable cycles to be determined to ensure the accuracy of the data and correctly judge whether the patient has entered the inspiratory phase.

[0064] Step S21 specifically includes the following steps:

[0065] The stable flow fluctuation amplitude of the gas path is obtained by taking the average and median of multiple stable breathing cycles, or filtering.

[0066] Specifically, in order to more accurately know whether the patient's respiratory cycle has entered the inhalation phase or the expiratory phase, it is necessary to judge through a stable respiratory cycle to determine the patient's accurate inhalation phase, so as to facilitate the delivery of nitric oxide in the inhalation phase of the patient's respiratory cycle. The stable airway flow fluctuation amplitude is obtained by using the mean, median or filtering method, which can be closer to the patient's actual respiratory cycle and the acquired data is more accurate.

[0067] See also Figure 3-4 , step S3 specifically includes the following steps:

[0068] Step S31: Difference is made between the current gas flow value and the gas phase threshold value of the respiratory cycle;

[0069] Step S32: when the current gas path flow value changes from being lower than the gas phase threshold of the respiratory cycle to being higher than the gas phase threshold of the respiratory cycle, it is determined that the patient's respiratory cycle is in the inspiratory phase;

[0070] Step S33: When the current gas flow value changes from being higher than the gas phase threshold of the respiratory cycle to being lower than the gas phase threshold of the respiratory cycle, or the gas flow value is always lower than the gas phase threshold of the respiratory cycle, it is determined that the patient's respiratory cycle is in the expiratory phase.

[0071] Specifically, the gas flow value can be obtained by placing a flow sensor at the air supply end of the ventilator to obtain the gas phase threshold of a stable breathing cycle. Since the air supply end of the ventilator is the same as the patient's breathing environment, the obtained data is more accurate. By comparing the gas phase threshold of the respiratory cycle with the current gas path flow value, when the current gas path flow value changes from lower than the gas phase threshold of the respiratory cycle to higher than the gas phase threshold of the respiratory cycle, at this time, the fluctuation amplitude of the gas path flow is rapidly rising and maintaining a high value, the flow in the gas path is rapidly transmitted to the patient, and the flow value climbs from a low value to a high value, that is, the patient continues to obtain gas from the ventilator, and the gas path flow value gradually increases. When the current gas path flow value changes from higher than the gas phase threshold of the respiratory cycle to lower than the gas phase threshold of the respiratory cycle, or the gas path flow value is always lower than the gas phase threshold of the respiratory cycle, that is, the patient continues to exhale and does not obtain gas from the ventilator. The patient's exhalation cannot increase the gas path flow value, and the flow value in the gas path will gradually decrease. Through this distinction point, the inhalation phase and the expiratory phase of the patient's respiratory cycle are distinguished, and nitric oxide is supplied to the patient in the inhalation phase.

[0072] As an example, Figure 5 As shown, the change in pressure on the ventilator and in the air circuit can be used to determine whether the patient has entered the inhalation phase, and a pressure sensor can be used to collect the current pressure value. When the pressure value changes from a low pressure value to a high pressure value, it can be determined to be in the inhalation phase. When the pressure value changes from a high pressure value to a high pressure value, it can be determined to be in the expiratory phase.

[0073] Second, see Figure 6 The present invention provides a nitric oxide supply device 1, which is connected to a ventilator 2 to provide nitric oxide gas for the ventilator 2. The device includes a gas production unit 11, a switching unit 12, a sensing unit 13, a control unit 14, a filtering unit 15, a purification unit 16, and a gas concentration detection unit 17; the gas production unit 11 is connected to the switching unit 12, the sensing unit 13 is connected to the gas outlet of the patient's ventilator 2, the control unit 14 is respectively connected to the gas production unit 11, the switching unit 12, and the sensing unit 13, one end of the filtering unit 15 is connected to the switching unit 12, and the other end is connected to the patient, one end of the purification unit 16 is connected to the switching unit 12, and the other end is connected to the external environment, the gas concentration detection unit 17 is connected to the control unit 14, and the gas concentration detection unit 17 is installed close to the patient.

[0074] Specifically, in the gas supply device, each unit is connected by a pipeline. The gas production unit 11 provides nitric oxide gas, the sensing unit 13 is used to sense and record the flow changes in the ventilator 2, and the control unit 14 controls the output end of the switching unit 12 by the flow change information fed back by the sensing unit 13 to determine whether it is in the inhalation phase and whether to output nitric oxide gas to the patient. The control unit 14 can also control the start and stop of the gas production unit 11, and the switching unit 12 can switch the direction of nitric oxide gas output. The switching unit 12 can switch the nitric oxide gas from the purification unit 16 to the atmosphere or to be filtered and delivered to the patient through the filtering unit 15. The gas concentration detection unit 17 is used to detect the proportion of various gases in the mixed gas delivered to the patient. When harmful gases are detected, the electrical signal is transmitted to the control unit 14 to stop the gas supply.

[0075] It can be understood that the sensing unit 13 senses the change of the flow value in the gas path and feeds back the electric signal to the control unit 14. The control unit 14 determines whether it belongs to the inhalation phase by obtaining the change of the electric signal of the sensing unit 13. If it is the inhalation phase, the switching unit 12 is controlled to make the therapeutic gas generated by the gas generation module flow to the filtering unit 15, and then delivered to the patient. Otherwise, the switching unit 12 is controlled to make the therapeutic gas flow to the purification unit 16, and then enter the atmosphere, so as to realize automatic gas supply and synchronous gas supply with the ventilator 2. The nitric oxide gas generated by the nitric oxide supply device 1 is only delivered to the air supply branch of the invasive ventilator 2 during the patient's inhalation phase, ensuring that the air supply rhythm of the nitric oxide supply device 1 and the invasive ventilator 2 remain synchronized to avoid false triggering of mechanical ventilation by the invasive ventilator 2. The nitric oxide supply device 1 only provides nitric oxide gas to the air supply branch of the invasive ventilator 2 during the patient's inhalation phase, avoiding the provision of nitric oxide during the patient's exhalation phase and the residual nitric oxide in the airway tube, thereby preventing nitric oxide from being converted into nitrogen dioxide. In addition, the air supply device only provides nitric oxide gas to the airway during the patient's inhalation phase, and stops providing nitric oxide gas during the exhalation phase, thereby ensuring that the expiratory tidal volume monitored by the invasive ventilator 2 is accurate.

[0076] In addition, before the gas supply device supplies nitric oxide gas to the ventilator 2 used by the patient, the sensing unit 13 first determines the type of the current ventilator 2 based on the change amplitude and frequency of the flow value. When the fluctuation of the respiratory flow exceeds a certain threshold, the control unit 14 determines that an invasive ventilator 2 is currently used, and then performs subsequent gas supply. When the respiratory flow is too small and less than the set threshold, the control unit 14 considers it to be an oxygen absorber or non-invasive ventilator 2 or other gas supply equipment, stops the gas generating unit from supplying gas, and switches the switching unit 12 to supplying gas to the purification unit 16.

[0077] The sensing unit 13 uses either a flow sensor or a pressure sensor. When a flow sensor or a pressure sensor is used, it can be connected to the air supply end of the ventilator 2 to monitor the flow value of the air circuit at the air supply end of the ventilator 2 or the gas pressure value in the air circuit in real time, and send the flow signal or pressure signal to the control unit 14. The control unit 14 analyzes the corresponding signal to determine whether the current patient's breathing cycle is in the expiratory phase or the inspiratory phase, thereby correspondingly controlling the switching unit 12 to switch the output end to output gas.

[0078] As an embodiment, the sensing unit 13 can be installed at any position of the gas circuit, and the gas circuit in the pipeline is in the same state. In this embodiment, the sensing unit 13 is set on the gas supply end of the ventilator 2 to obtain the best effect, but the installation position of the sensing unit 13 is not limited to the position in this embodiment.

[0079] The switching unit 12 includes a three-way solenoid valve, which is respectively connected to the gas production unit 11, the filtering unit 15, and the purification unit 16. One end of the three-way solenoid valve receives the gas from the gas production unit 11, and the other two ends output to the filtering unit 15 and the purification unit 16. The three-way solenoid valve cooperates with equipment such as a motor to control the opening and closing of the output port of the three-way solenoid valve, so as to control the timing of the output of nitric oxide gas. When the patient is inhaling, the three-way solenoid valve is connected to one end of the filtering unit 15 to output gas, so that the nitric oxide gas is synchronized with the air supply of the ventilator 2; in addition, a three-way solenoid valve is arranged in the switching unit 12, and the opening and closing of the valve can be controlled by an electrical signal, thereby reducing manual operation, making the equipment simpler, and improving the degree of automation of the device. At the same time, the response speed of the equipment is improved to avoid the output of nitric oxide during the patient's exhalation phase.

[0080] The gas generating unit obtains nitric oxide gas from the clean air by ionization or other methods, and the gas generating unit works continuously to continuously output nitric oxide gas to the switching unit 12 .

[0081] The device includes a gas mixing unit 18, which is installed at the connection port between the patient and the ventilator 2 pipeline, or on the ventilator worn on the patient. The gas mixing unit 18 is used to fully mix the generated therapeutic gas with the mixed gas of oxygen and air supplied by the ventilator 2 to facilitate the patient's absorption; in addition, the gas mixing unit 18 and the gas concentration detection unit 17 are both arranged on the patient's breathing duct, so that the gas concentration detection unit 17 can obtain a more accurate concentration of the therapeutic gas.

[0082] In particular, the purification unit 16 is loaded with absorbents of nitrides, including soda lime, calcium lime, activated carbon or charcoal and other substances with strong adsorption capacity, to achieve maximum catalysis and absorption of harmful gases discharged into the atmosphere, so that the gases discharged into the atmosphere meet the safety emission standards.

[0083] In particular, the filtration unit 15 uses either an adsorption method or a membrane separation method to remove impurities from the nitric oxide gas generated in the gas generation unit, such as nitrogen dioxide, ozone, residual water vapor, etc., thereby delivering safe and pure therapeutic gas to the patient.

[0084] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0085] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0086] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0087] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be connected, detachably connected, or integrated; it can be mechanically connected or electrically connected; it can be directly connected or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0088] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0089] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms should not be understood as necessarily referring to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification.

[0090] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

[0091] The above is a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present invention, and these modifications or replacements should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be based on the protection scope of the claims.

Claims

1. A nitric oxide gas supply device, characterized in that: It includes a gas production unit, a switching unit, a sensing unit, and a control unit; The gas production unit is connected to the switching unit, the sensing unit is connected to the gas outlet of the patient's ventilator, and the control unit is respectively connected to the gas production unit, the switching unit, and the sensing unit; The sensing unit is used to sense and record the change of flow in the ventilator, and the switching unit can switch the direction of nitric oxide gas output; The sensing unit senses the change of the flow value in the gas path and feeds back the change to the control unit through an electrical signal. The control unit controls the output end of the switching unit based on the flow change information fed back by the sensing unit to determine whether it is in the inhalation phase and whether to output nitric oxide gas to the ventilator. The nitric oxide gas supply device performs the following nitric oxide gas supply method: Based on the respiratory cycle data in the ventilator, the gas phase threshold of the respiratory cycle is calculated; according to the respiratory cycle data in the ventilator, the flow fluctuation amplitude of the gas circuit is determined, and the peak-to-peak value of the gas circuit flow amplitude is obtained based on the flow fluctuation amplitude of the gas circuit, and the gas phase threshold of the respiratory cycle in the ventilator is obtained based on the peak-to-peak value of the flow amplitude; The gas phase threshold of the respiratory cycle is compared with the change of the flow value in the gas circuit sensed by the sensing unit; the current gas circuit flow value sensed by the sensing unit is judged from the feedback electrical signal that the current gas circuit flow value changes from below the gas phase threshold of the respiratory cycle to above the gas phase threshold of the respiratory cycle, and the respiratory cycle in the ventilator is judged to be in the inhalation phase; the current gas circuit flow value sensed by the sensing unit is judged from the feedback electrical signal that the current gas circuit flow value changes from above the gas phase threshold of the respiratory cycle to below the gas phase threshold of the respiratory cycle, or the gas circuit flow value is always below the gas phase threshold of the respiratory cycle, and the respiratory cycle in the ventilator is judged to be in the expiratory phase.

2. The nitric oxide supply device according to claim 1, characterized in that: Determining the flow fluctuation amplitude of the gas circuit according to the respiratory cycle data in the ventilator includes: taking the mean and median according to the respiratory cycle data in the ventilator, or filtering to obtain a stable flow fluctuation amplitude of the gas circuit.

3. The nitric oxide supply device according to claim 1, characterized in that: It comprises a filtering unit and a purification unit. One end of the filtering unit is connected to the switching unit, and the other end is connected to the patient. One end of the purification unit is connected to the switching unit, and the other end is connected to the external environment.

4. The nitric oxide supply device according to claim 3, characterized in that: The purification unit is loaded with an absorbent for nitrides.

5. The nitric oxide supply device according to claim 3, characterized in that: The filtration unit uses either adsorption method or membrane separation method to remove impurities from the gas.

6. The nitric oxide supply device according to claim 3, characterized in that: The switching unit comprises a three-way solenoid valve, and the three-way solenoid valve is respectively connected to the gas production unit, the filtering unit, and the purification unit.

7. The nitric oxide supply device according to claim 1, characterized in that: It includes a gas concentration detection unit, which is connected to the control unit and installed close to the patient.

8. The nitric oxide supply device according to claim 1, characterized in that: The sensing unit is a flow sensor or a pressure sensor.

9. The nitric oxide supply device according to claim 1, characterized in that: The invention comprises a gas mixing unit, which is installed at the connection port between the patient and the breathing machine pipeline, or on the breathing machine worn on the patient.

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