A long-acting moisturizing contact lens care solution and a method of making the same

Abstract

The application provides a long-acting moisturizing contact lens care solution and a preparation method thereof. The contact lens care solution comprises, by mass fraction, 0.1-2 parts of a pH regulator, 0.5-2 parts of an osmotic pressure regulator, 0.01-2 parts of a humectant, 0.01-0.5 parts of a complexing agent, 0.0001-0.02 parts of an antibacterial agent and 95-99 parts of purified water; wherein the humectant comprises, by mass fraction, 0.01-0.5 parts of hydroxypropyl methyl cellulose, 0.1-2 parts of polyvinyl pyrrolidone and 0.01-1 parts of modified ectoine. The hydroxypropyl methyl cellulose, polyvinyl pyrrolidone and modified ectoine as the humectant have good hydrophilicity, stability and adhesion, can be adsorbed on the surface of a contact object for a long time and retain moisture, thereby effectively improving and prolonging the moisturizing effect of the contact lens care solution.

Description

Technical Field

[0001] This application relates to the field of contact lens care technology, and in particular to a long-lasting moisturizing contact lens care solution and its preparation method. Background Technology

[0002] Contact lens solution is a care product that provides contact lens users with cleaning, disinfection, and storage services for their lenses. With the increasing number of contact lens users, the contact lens solution market has grown accordingly. Existing contact lens solutions not only focus on product effectiveness and safety but are also constantly exploring new formulations to meet a wider range of user needs.

[0003] Existing contact lens solutions mainly contain the following ingredients: pH adjusters, such as boric acid and nitric acid, to maintain the acid-base balance of the solution to adapt to the natural environment of the eye; osmotic pressure adjusters, such as sodium chloride, potassium chloride, and phosphates, to maintain an osmotic pressure similar to that of tears, reducing eye discomfort; moisturizers, such as trehalose, hyaluronic acid, and glycerin, to retain moisture in the contact lenses and improve wearing comfort; complexing agents, such as disodium edetate, to remove minerals and dirt from the lenses; and antibacterial agents, such as polyhexyl guanidine, to prevent the growth of microorganisms and ensure the hygiene and safety of the solution.

[0004] However, existing contact lens solutions generally have only moderate moisturizing effects, providing only temporary hydration and failing to maintain the comfort of contact lens wearers for extended periods. Summary of the Invention

[0005] In view of the aforementioned problems, this application is made to provide a long-lasting moisturizing contact lens solution and a method for preparing the same, which overcomes or at least partially solves the problems, comprising:

[0006] A long-lasting moisturizing contact lens care solution, comprising, by weight parts: 0.1-2 parts pH adjuster, 0.5-2 parts osmotic pressure adjuster, 0.01-2 parts moisturizer, 0.01-0.5 parts complexing agent, 0.0001-0.02 parts antibacterial agent, and 95-99 parts purified water;

[0007] The humectant comprises, by weight parts: 0.01-0.5 parts hydroxypropyl methylcellulose, 0.1-2 parts polyvinylpyrrolidone, and 0.01-1 parts modified ectoine; the structural formula of the modified ectoine is:

[0008]

[0009] Where R is -(CH2-CH2-O) n -H, 4≤n≤20.

[0010] Preferably, R is -(CH2-CH2-O) n -H, 10≤n≤14.

[0011] Preferably, the pH adjuster comprises, by mass parts: 0.1-2 parts boric acid and 0.1-1 parts borax.

[0012] Preferably, the osmotic pressure regulator comprises, by weight parts: 0.1-0.9 parts sodium chloride, 0.05-0.5 parts potassium chloride, and 0.05-0.5 parts sodium dihydrogen phosphate.

[0013] Preferably, the complexing agent comprises, by mass parts: 0.01-2 parts of trisodium citrate, 0.01-2 parts of poloxamer 407, and 0.01-0.5 parts of disodium edetate.

[0014] Preferably, the antibacterial agent is polyhexamethylene biguanide hydrochloride.

[0015] A method for preparing a contact lens care solution as described in any of the above claims, comprising:

[0016] Hydroxypropyl methylcellulose, polyvinylpyrrolidone, modified ectoine, complexing agent and antibacterial agent are dissolved in the purified water according to the specified ratio to obtain a mixed solution;

[0017] Add a pH adjuster to the mixed solution to adjust the pH value to 6.7-7.7, and add an osmotic pressure adjuster to adjust the osmotic pressure to 260-340 mosm / kg·H2O to obtain a contact lens care solution.

[0018] Preferred options also include:

[0019] Ectoin and low molecular weight polyethylene glycol are dissolved separately in organic solvents; wherein the low molecular weight polyethylene glycol has the structural formula HO-(CH2-CH2-O). n -H, 4≤n≤20; the mass ratio of the ectoine to the low molecular weight polyethylene glycol is 1:(1-3);

[0020] The low molecular weight polyethylene glycol is activated by adding an activator; wherein the activator is N,N'-dicyclohexylcarbodiimide; the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:(0.5-1.2);

[0021] The activated polyethylene glycol solution was added to the ectoine solution and stirred at room temperature for 8-12 hours.

[0022] The reaction product was separated, purified, and dried to obtain the modified ectoine.

[0023] This application has the following advantages:

[0024] In the embodiments of this application, in response to the relatively weak moisturizing effect of existing contact lens solutions, this application provides a solution by adding modified ectoine as a long-lasting moisturizing ingredient, specifically: "A long-lasting moisturizing contact lens solution, comprising, by weight parts: 0.1-2 parts pH adjuster, 0.5-2 parts osmotic pressure adjuster, 0.01-2 parts moisturizer, 0.01-0.5 parts complexing agent, 0.0001-0.02 parts antibacterial agent, and 95-99 parts purified water; wherein the moisturizer comprises, by weight parts: 0.01-0.5 parts hydroxypropyl methylcellulose, 0.1-2 parts polyvinylpyrrolidone, and 0.01-1 parts modified ectoine; the structural formula of the modified ectoine is:" Where R is -(CH2-CH2-O) n -H, 4≤n≤20". Hydroxypropyl methylcellulose, polyvinylpyrrolidone, and modified ectoine serve as humectants, exhibiting excellent hydrophilicity, stability, and adhesion. They can be adsorbed onto the surface of the contact object for a long time and retain moisture, thereby effectively enhancing and prolonging the moisturizing effect of the contact lens care solution. Attached Figure Description

[0025] To more clearly illustrate the technical solution of this application, the drawings used in the description of this application will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0026] Figure 1 This is a flowchart of the steps in preparing a long-lasting moisturizing contact lens care solution according to an embodiment of this application;

[0027] Figure 2 This is a flowchart of the preparation method of a long-lasting moisturizing contact lens care solution provided in another embodiment of this application. Detailed Implementation

[0028] To make the objectives, features, and advantages of this application more apparent and understandable, the application will be further described in detail below with reference to the accompanying drawings and specific embodiments. Obviously, the described embodiments are only some, not all, of the embodiments of this application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0029] In one embodiment of this application, a long-lasting moisturizing contact lens care solution is provided, comprising, by weight parts: 0.1-2 parts of pH adjuster, 0.5-2 parts of osmotic pressure adjuster, 0.01-2 parts of moisturizer, 0.01-0.5 parts of complexing agent, 0.0001-0.02 parts of antibacterial agent, and 95-99 parts of purified water;

[0030] The humectant comprises, by weight parts: 0.01-0.5 parts hydroxypropyl methylcellulose, 0.1-2 parts polyvinylpyrrolidone, and 0.01-1 parts modified ectoine; the structural formula of the modified ectoine is:

[0031]

[0032] Wherein, R is -(CH2-CH2-O) n -H, 4≤n≤20.

[0033] It should be noted that hydroxypropyl methylcellulose can effectively absorb moisture, forming a moisturizing layer on the surface of the eyeball to provide a long-lasting feeling of hydration; it can also increase the viscosity of the contact lens solution, which helps reduce friction on the eyes.

[0034] Polyvinylpyrrolidone has excellent moisturizing and lubricating properties, which can significantly improve the comfort of the wearer; it also has good stability, remaining stable under various temperature and pH conditions, and providing a continuous moisturizing effect.

[0035] Modified ectoine is obtained by grafting ectoine with low molecular weight polyethylene glycol; wherein, the structural formula of low molecular weight polyethylene glycol is: HO-(CH2-CH2-O). n -H, 4≤n≤20; the synthetic reaction equation for modified ectoine is:

[0036]

[0037] The macromolecular structure formed by grafting ectoine with low molecular weight polyethylene glycol can form a thin film on the surface of the contact material, which helps to reduce water evaporation and improve moisturizing performance. Polyethylene glycol is a highly hydrophilic polymer, and each of its repeating units (-CH2-CH2-O-) can form hydrogen bonds with water molecules, thereby effectively attracting and retaining moisture. In addition, grafting ectoine with polyethylene glycol increases the overall molecular size and stability, reduces the evaporation rate of molecules, and thus provides a longer-lasting moisturizing effect.

[0038] In the embodiments of this application, in response to the relatively weak moisturizing effect of existing contact lens solutions, this application provides a solution by adding modified ectoine as a long-lasting moisturizing ingredient, specifically: "A long-lasting moisturizing contact lens solution, comprising, by weight parts: 0.1-2 parts pH adjuster, 0.5-2 parts osmotic pressure adjuster, 0.01-2 parts moisturizer, 0.01-0.5 parts complexing agent, 0.0001-0.02 parts antibacterial agent, and 95-99 parts purified water; wherein the moisturizer comprises, by weight parts: 0.01-0.5 parts hydroxypropyl methylcellulose, 0.1-2 parts polyvinylpyrrolidone, and 0.01-1 parts modified ectoine; the structural formula of the modified ectoine is:" Where R is -(CH2-CH2-O) n -H, 4≤n≤20". Hydroxypropyl methylcellulose, polyvinylpyrrolidone, and modified ectoine serve as humectants, exhibiting excellent hydrophilicity, stability, and adhesion. They can be adsorbed onto the surface of the contact object for a long time and retain moisture, thereby effectively enhancing and prolonging the moisturizing effect of the contact lens care solution.

[0039] The following will further describe a long-lasting moisturizing contact lens care solution in this exemplary embodiment.

[0040] In this embodiment, R is -(CH2-CH2-O). n -H, 10≤n≤14. By grafting ectoin with polyethylene glycol of the above molecular weight, the reaction product not only has good hydrophilicity and stability, but also high solubility and low viscosity, which helps to disperse uniformly in the system.

[0041] In this embodiment, the pH adjuster comprises, by weight, 0.1-2 parts boric acid and 0.1-1 parts borax. Boric acid and borax, as the pH adjuster, can cover a wide pH range, allowing for precise adjustment of the system's pH value to meet production requirements; and they possess good stability, resisting pH changes and helping to maintain stable product performance.

[0042] In this embodiment, the osmotic pressure regulator comprises, by weight, 0.1-0.9 parts sodium chloride, 0.05-0.5 parts potassium chloride, and 0.05-0.5 parts sodium dihydrogen phosphate. Sodium chloride, potassium chloride, and sodium dihydrogen phosphate are commonly found in the human body, have good physiological compatibility, and can regulate the osmotic pressure of the product to be close to the physiological osmotic pressure of the human body, thereby reducing stimulation or damage to cells.

[0043] In this embodiment, the complexing agent comprises, by weight, 0.01-2 parts of trisodium citrate, 0.01-2 parts of poloxamer 407, and 0.01-0.5 parts of disodium edetate. Poloxamer 407, as a surfactant, enhances the ability of the contact lens solution to remove protein deposits and lipid contaminants from contact lenses, maintaining their cleanliness; it also increases the lubricity of contact lenses, reducing discomfort and improving comfort during wear. Trisodium citrate and disodium edetate, by forming stable complexes with metal ions in water, prevent these ions from catalyzing the degradation of other components in the contact lens solution, thereby enhancing the stability and safety of the solution; they also help neutralize metal ions that may cause eye irritation, maintaining the mildness of the solution.

[0044] In this embodiment, the antibacterial agent is polyhexamethylene biguanide hydrochloride. Polyhexamethylene biguanide hydrochloride has good antibacterial effects against a variety of bacteria and certain fungi, helping to prevent microbial contamination and growth, and keeping contact lenses clean and hygienic; and at appropriate concentrations, it is relatively mild and has low toxicity, which can reduce irritation and discomfort to the eyes.

[0045] Reference Figure 1 In one embodiment of this application, a method for preparing a contact lens care solution as described in any of the above embodiments is also provided, comprising:

[0046] S110. Hydroxypropyl methylcellulose, polyvinylpyrrolidone, modified ectoine, complexing agent and antibacterial agent are dissolved in the purified water according to the formula to obtain a mixed solution;

[0047] S120. Add a pH adjuster to the mixed solution to adjust the pH value to 6.7-7.7, and add an osmotic pressure adjuster to adjust the osmotic pressure to 260-340 mosm / kg·H2O to obtain a contact lens care solution.

[0048] As described in step S110, hydroxypropyl methylcellulose, polyvinylpyrrolidone, modified ectoine, complexing agent and antibacterial agent are dissolved in the purified water according to the specified ratio to obtain a mixed solution.

[0049] Weigh out the pH adjuster, osmotic pressure adjuster, hydroxypropyl methylcellulose, polyvinylpyrrolidone, modified ectoine, complexing agent, antibacterial agent, and purified water according to the specified ratio; add the hydroxypropyl methylcellulose, polyvinylpyrrolidone, modified ectoine, complexing agent, and antibacterial agent to the purified water, and stir at room temperature (about 25°C) until completely dissolved to obtain a mixed solution.

[0050] As described in step S120, a pH adjuster is added to the mixed solution to adjust the pH value to 6.7-7.7, and an osmotic pressure adjuster is added to adjust the osmotic pressure to 260-340 mosm / kg·H2O to obtain a contact lens care solution.

[0051] The pH value of the solution is monitored using a pH meter, and the pH adjuster is slowly added while stirring until the pH value of the solution is adjusted to 6.7-7.7; the osmotic pressure of the solution is measured using an osmometer, and the osmotic pressure adjuster is slowly added while stirring until the osmotic pressure of the solution is adjusted to 260-340 mosm / kg·H2O, thus obtaining the contact lens care solution.

[0052] Reference Figure 2 In one embodiment of this application, the preparation method further includes:

[0053] S010. Ectoin and low molecular weight polyethylene glycol are dissolved in organic solvents respectively; wherein, the structural formula of the low molecular weight polyethylene glycol is HO-(CH2-CH2-O). n -H, 4≤n≤20; the mass ratio of the ectoine to the low molecular weight polyethylene glycol is 1:(1-3);

[0054] S020. Activate the low molecular weight polyethylene glycol by adding an activator; wherein the activator is N,N'-dicyclohexylcarbodiimide; the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:(0.5-1.2);

[0055] S030. Add the activated polyethylene glycol solution to the ectoine solution and stir the reaction at room temperature for 8-12 hours.

[0056] S040. The reaction product is separated, purified, and dried to obtain the modified ectoine.

[0057] As described in step S010, ectoine and low molecular weight polyethylene glycol are dissolved in organic solvents respectively; wherein, the structural formula of the low molecular weight polyethylene glycol is HO-(CH2-CH2-O). n -H, 4≤n≤20; the mass ratio of the ectoine to the low molecular weight polyethylene glycol is 1:(1-3).

[0058] Weigh ectoine and low molecular weight polyethylene glycol according to the specified ratio; add ectoine and low molecular weight polyethylene glycol to an organic solvent respectively, and stir at room temperature until completely dissolved; wherein, the organic solvent includes at least one of anhydrous ethanol and dichloromethane.

[0059] As described in step S020, an activator is added to activate the low molecular weight polyethylene glycol; wherein the activator is N,N'-dicyclohexylcarbodiimide; the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:(0.5-1.2).

[0060] Weigh out the activator N,N'-dicyclohexylcarbodiimide according to the specified ratio; add the activator to a low molecular weight polyethylene glycol solution and stir at room temperature to ensure that the activator is uniformly dispersed and reacts fully.

[0061] As described in step S030, the activated polyethylene glycol solution is added to the ectoine solution and stirred at room temperature for 8-12 hours.

[0062] The activated polyethylene glycol solution is slowly added to the ectoine solution, and the mixture is stirred continuously at room temperature for 8-12 hours to ensure a complete reaction. A stirred reactor can be used, and the solution temperature and stirring speed should be monitored.

[0063] As described in step S040, the reaction product is separated, purified, and dried to obtain the modified ectoine.

[0064] The reaction products and unreacted solvents and activators are separated using equipment such as a separating funnel or centrifuge; the product is further purified by washing, filtration or chromatography to remove unreacted raw materials and byproducts; the purified product is dried under reduced pressure or using a freeze dryer to obtain the final modified ectoine.

[0065] Example 1

[0066] A long-lasting moisturizing contact lens solution, comprising, by weight:

[0067] The mixture comprises 0.2 parts pH adjuster, 1 part osmotic pressure adjuster, 0.2 parts hydroxypropyl methylcellulose, 1.2 parts polyvinylpyrrolidone, 0.2 parts modified ectoine, 0.1 parts complexing agent, 0.01 parts antibacterial agent, and 98 parts purified water; the structural formula of the modified ectoine is:

[0068]

[0069] Wherein, R is -(CH2-CH2-O)4-H.

[0070] The method for preparing the contact lens care solution includes:

[0071] Ectoin and low molecular weight polyethylene glycol (MWPEG) were dissolved separately in an organic solvent; wherein the MWPEG has the structural formula HO-(CH2-CH2-O)4-H; the mass ratio of ectoin to MWPEG was 1:1; N,N'-dicyclohexylcarbodiimide was added as an activator to activate the MWPEG; wherein the mass ratio of MWPEG to activator was 1:1.2; the activated MWPEG solution was added to the ectoin solution and stirred at room temperature for 8 hours; the reaction product was separated, purified, and dried to obtain modified ectoin.

[0072] Hydroxypropyl methylcellulose, polyvinylpyrrolidone, the modified ectoine, the complexing agent, and the antibacterial agent were dissolved in purified water according to the specified ratio to obtain a mixed solution. A pH adjuster was added to the mixed solution to adjust the pH value to 7, and an osmotic pressure adjuster was added to adjust the osmotic pressure to 300 mosm / kg·H2O to obtain a contact lens care solution.

[0073] Example 2

[0074] A long-lasting moisturizing contact lens solution, comprising, by weight:

[0075] The mixture comprises 0.5 parts pH adjuster, 1 part osmotic pressure adjuster, 0.1 part hydroxypropyl methylcellulose, 1.2 parts polyvinylpyrrolidone, 0.15 parts modified ectoine, 0.1 part complexing agent, 0.01 part antibacterial agent, and 97 parts purified water; the structural formula of the modified ectoine is:

[0076]

[0077] Where R is -(CH2-CH2-O) 10 -H.

[0078] The method for preparing the contact lens care solution includes:

[0079] Ectoin and low molecular weight polyethylene glycol are dissolved separately in organic solvents; wherein the low molecular weight polyethylene glycol has the structural formula HO-(CH2-CH2-O). 10 -H; the mass ratio of ectoine to the low molecular weight polyethylene glycol is 1:2; the low molecular weight polyethylene glycol is activated by adding activator N,N'-dicyclohexylcarbodiimide; wherein the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:1; the activated polyethylene glycol solution is added to the ectoine solution and stirred at room temperature for 10 h; the reaction product is separated, purified and dried to obtain modified ectoine;

[0080] Hydroxypropyl methylcellulose, polyvinylpyrrolidone, the modified ectoine, the complexing agent, and the antibacterial agent were dissolved in purified water according to the specified ratio to obtain a mixed solution. A pH adjuster was added to the mixed solution to adjust the pH value to 7, and an osmotic pressure adjuster was added to adjust the osmotic pressure to 300 mosm / kg·H2O to obtain a contact lens care solution.

[0081] Example 3

[0082] A long-lasting moisturizing contact lens solution, comprising, by weight:

[0083] The mixture comprises 1 part pH adjuster, 1.5 parts osmotic pressure adjuster, 0.2 parts hydroxypropyl methylcellulose, 1 part polyvinylpyrrolidone, 0.1 parts modified ectoine, 0.1 parts complexing agent, 0.01 parts antibacterial agent, and 97 parts purified water; the structural formula of the modified ectoine is:

[0084]

[0085] Wherein, R is -(CH2-CH2-O) 12 -H.

[0086] The method for preparing the contact lens care solution includes:

[0087] Ectoin and low molecular weight polyethylene glycol are dissolved separately in organic solvents; wherein the low molecular weight polyethylene glycol has the structural formula HO-(CH2-CH2-O). 12 -H; the mass ratio of ectoine to the low molecular weight polyethylene glycol is 1:2; the low molecular weight polyethylene glycol is activated by adding activator N,N'-dicyclohexylcarbodiimide; wherein the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:1; the activated polyethylene glycol solution is added to the ectoine solution and stirred at room temperature for 10 h; the reaction product is separated, purified and dried to obtain modified ectoine;

[0088] Hydroxypropyl methylcellulose, polyvinylpyrrolidone, the modified ectoine, the complexing agent, and the antibacterial agent were dissolved in purified water according to the specified ratio to obtain a mixed solution. A pH adjuster was added to the mixed solution to adjust the pH value to 7, and an osmotic pressure adjuster was added to adjust the osmotic pressure to 300 mosm / kg·H2O to obtain a contact lens care solution.

[0089] Example 4

[0090] A long-lasting moisturizing contact lens solution, comprising, by weight:

[0091] The mixture comprises 1 part pH adjuster, 1.5 parts osmotic pressure adjuster, 0.2 parts hydroxypropyl methylcellulose, 1 part polyvinylpyrrolidone, 0.08 parts modified ectoine, 0.1 parts complexing agent, 0.01 parts antibacterial agent, and 96 parts purified water; the structural formula of the modified ectoine is:

[0092]

[0093] Wherein, R is -(CH2-CH2-O) 14 -H.

[0094] The method for preparing the contact lens care solution includes:

[0095] Ectoin and low molecular weight polyethylene glycol are dissolved separately in organic solvents; wherein the low molecular weight polyethylene glycol has the structural formula HO-(CH2-CH2-O). 14 -H; the mass ratio of ectoine to the low molecular weight polyethylene glycol is 1:2; the low molecular weight polyethylene glycol is activated by adding activator N,N'-dicyclohexylcarbodiimide; wherein the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:1; the activated polyethylene glycol solution is added to the ectoine solution and stirred at room temperature for 10 h; the reaction product is separated, purified and dried to obtain modified ectoine;

[0096] Hydroxypropyl methylcellulose, polyvinylpyrrolidone, the modified ectoine, the complexing agent, and the antibacterial agent were dissolved in purified water according to the specified ratio to obtain a mixed solution. A pH adjuster was added to the mixed solution to adjust the pH value to 7, and an osmotic pressure adjuster was added to adjust the osmotic pressure to 300 mosm / kg·H2O to obtain a contact lens care solution.

[0097] Example 5

[0098] A long-lasting moisturizing contact lens solution, comprising, by weight:

[0099] The mixture comprises 0.5 parts pH adjuster, 0.8 parts osmotic pressure adjuster, 0.3 parts hydroxypropyl methylcellulose, 0.8 parts polyvinylpyrrolidone, 0.05 parts modified ectoine, 0.1 parts complexing agent, 0.01 parts antibacterial agent, and 97 parts purified water; the structural formula of the modified ectoine is:

[0100]

[0101] Wherein, R is -(CH2-CH2-O) 20 -H.

[0102] The method for preparing the contact lens care solution includes:

[0103] Ectoin and low molecular weight polyethylene glycol are dissolved separately in organic solvents; wherein the low molecular weight polyethylene glycol has the structural formula HO-(CH2-CH2-O). 20 -H; the mass ratio of ectoine to the low molecular weight polyethylene glycol is 1:3; the low molecular weight polyethylene glycol is activated by adding activator N,N'-dicyclohexylcarbodiimide; wherein the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:0.8; the activated polyethylene glycol solution is added to the ectoine solution and stirred at room temperature for 12 hours; the reaction product is separated, purified and dried to obtain modified ectoine;

[0104] Hydroxypropyl methylcellulose, polyvinylpyrrolidone, the modified ectoine, the complexing agent, and the antibacterial agent were dissolved in purified water according to the specified ratio to obtain a mixed solution. A pH adjuster was added to the mixed solution to adjust the pH value to 7, and an osmotic pressure adjuster was added to adjust the osmotic pressure to 300 mosm / kg·H2O to obtain a contact lens care solution.

[0105] Comparative Example 1

[0106] A contact lens care solution, which differs from Example 1 in that it does not contain modified ectoine.

[0107] The preparation method of the contact lens care solution differs from that of Example 1 in that it does not include the preparation and addition steps of modified ectoine.

[0108] Comparative Example 2

[0109] A contact lens care solution, which differs from Example 3 in that it does not contain modified ectoine.

[0110] The preparation method of the contact lens care solution differs from that of Example 3 in that it does not include the preparation and addition steps of modified ectoine.

[0111] Comparative Example 3

[0112] The contact lens solution differs from that in Example 5 in that it does not contain modified ectoine.

[0113] The preparation method of the contact lens care solution differs from that of Example 5 in that it does not include the preparation and addition steps of modified ectoine.

[0114] Cytotoxicity test

[0115] Add 100 μl of a 1×10⁻⁶ solution to each well of a 96-well plate. 5A suspension of corneal stromal cells per cell / mL was prepared and placed in an incubator containing 5% CO2 at 37°C for 24 hours. After 2 hours of culture, the culture medium was aspirated. Examples 1-5 and Comparative Examples 1-3 were mixed with complete culture medium at a ratio of 1:10 and added to 96-well plates for further cell culture for 24 hours. 10% DMSO was used as a positive control, and complete cell culture medium was used as a negative control. All samples and control groups were replicated in six places. After cell culture, 20 μl / well of MTT solution was added, and incubation continued for 3 hours. Then, 100 μl of DMSO was added and the plate was shaken for 10 minutes to completely dissolve the methyl violet crystals. The absorbance was measured at 570 nm using a microplate reader, and cell viability was calculated using the following formula: Cell viability = (OD value of test sample well - OD value of blank control well) / OD value of negative control well × 100%. The results are shown in Table 1.

[0116] Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Cell viability 99.20％ 99.10％ 99.40％ 98.90％ 99.30％ 98.30％ 98.50％ 98％

[0117] Table 1. Cytotoxicity test results of Examples 1-5 and Comparative Examples 1-3

[0118] As can be seen from Table 1, after culturing corneal stromal cells for 24 hours in Examples 1-5 and Comparative Examples 1-3, the cell survival rate was above 95%, indicating that Examples 1-5 and Comparative Examples 1-3 are safe and non-toxic to corneal cells.

[0119] Moisturizing effect test

[0120] Eight sets of identical silicone hydrogel contact lenses were prepared, with six replicates per set. The dry weight of each contact lens was measured using a precision electronic balance. The eight sets of contact lenses were immersed in Examples 1-5 and Comparative Examples 1-3, respectively, for 24 hours. After immersion, the contact lenses were removed, surface liquid was wiped off, and the wet weight was measured using a precision electronic balance. They were then placed in a dry environment at 35°C and 40% relative humidity. The wet weight of the contact lenses was measured every hour using a precision electronic balance, and the water content was calculated using the following formula: Water content = (Wet weight - Dry weight) / Wet weight × 100%. The results are shown in Table 2.

[0121] Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 1 hour moisture content 88％ 87％ 89％ 88％ 87％ 86％ 86％ 85％ 2h moisture content 86％ 85％ 87％ 86％ 85％ 84％ 84％ 83％ 3-hour moisture content 84％ 83％ 85％ 84％ 83％ 82％ 81％ 81％ 4-hour moisture content 82％ 81％ 83％ 82％ 81％ 80％ 79％ 79％ 6-hour moisture content 79％ 78％ 80％ 79％ 78％ 75％ 74％ 74％ 8-hour moisture content 76％ 75％ 77％ 76％ 75％ 70％ 69％ 69％ 10-hour moisture content 73％ 72％ 74％ 73％ 72％ 65％ 64％ 64％ 12h moisture content 70％ 69％ 71％ 70％ 69％ 60％ 59％ 59％ 14-hour moisture content 67％ 66％ 68％ 67％ 66％ 55％ 54％ 54％ 16h moisture content 64％ 63％ 65％ 64％ 63％ 50％ 49％ 49％

[0122] Table 2. Results of moisturizing effect tests in Examples 1-5 and Comparative Examples 1-3

[0123] As can be seen from Table 2, from the 6th hour onwards, the water content of Examples 1-5 was significantly higher than that of Comparative Examples 1-3, indicating that Examples 1-5 can significantly improve and prolong the moisturizing effect.

[0124] Evaluation of usage effect

[0125] Forty-eight volunteers, regardless of gender, who experienced discomfort such as dry eyes and fatigue due to prolonged contact lens wear, were randomly selected and divided into eight groups. The eight groups of volunteers each tried wearing contact lenses soaked in Examples 1-5 and Comparative Examples 1-3 for three consecutive days, 16 hours per day. The test results were scored using the following criteria: 1 point - poor, 2 points - quite poor, 3 points - average, 4 points - good, 5 points - very good. The results are shown in Table 3.

[0126] Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comfort of use 4.5 4.6 4.7 4.4 4.5 3.8 3.5 3.3

[0127] Table 3 Evaluation results of the usage effects of Examples 1-5 and Comparative Examples 1-3

[0128] As can be seen from Table 3, the comfort scores of Examples 1-5 are significantly higher than those of Comparative Examples 1-3, indicating that Examples 1-5 can significantly alleviate discomfort symptoms such as dryness and fatigue caused by long-term contact lens wear and improve the comfort of wearing contact lenses.

[0129] Although preferred embodiments of the present application have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the embodiments of the present application.

[0130] Finally, it should be noted that in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or terminal device that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or terminal device. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or terminal device that includes said element.

[0131] The above provides a detailed description of a long-lasting moisturizing contact lens care solution and its preparation method. Specific examples have been used to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A long-lasting moisturizing contact lens solution, characterized in that, The product comprises, by weight parts: 0.1-2 parts pH adjuster, 0.5-2 parts osmotic pressure adjuster, 0.01-2 parts humectant, 0.01-0.5 parts complexing agent, 0.0001-0.02 parts antibacterial agent, and 95-99 parts purified water; The humectant comprises, by weight parts: 0.01-0.5 parts hydroxypropyl methylcellulose, 0.1-2 parts polyvinylpyrrolidone, and 0.01-1 parts modified ectoine; the modified ectoine is obtained by grafting ectoine with low molecular weight polyethylene glycol to form a macromolecular structure; the structural formula of the modified ectoine is: ； Where R is -(CH2-CH2-O) n -H, 4≤n≤20; The preparation steps of the modified ectoine include: Ectoin and low molecular weight polyethylene glycol are dissolved in organic solvents respectively; wherein the mass ratio of ectoin to low molecular weight polyethylene glycol is 1:(1-3); The low molecular weight polyethylene glycol is activated by adding an activator; wherein the activator is N,N'-dicyclohexylcarbodiimide; the mass ratio of the low molecular weight polyethylene glycol to the activator is 1:(0.5-1.2); The activated polyethylene glycol solution was added to the ectoine solution and stirred at room temperature for 8-12 hours. The reaction product was separated, purified, and dried to obtain the modified ectoine.

2. The contact lens solution according to claim 1, characterized in that, R stands for -(CH2-CH2-O) n -H, 10≤n≤14.

3. The contact lens solution according to claim 1, characterized in that, The pH adjuster comprises, by mass parts: 0.1-2 parts boric acid and 0.1-1 parts borax.

4. The contact lens solution according to claim 1, characterized in that, The osmotic pressure regulator comprises, by weight, 0.1-0.9 parts of sodium chloride, 0.05-0.5 parts of potassium chloride, and 0.05-0.5 parts of sodium dihydrogen phosphate.

5. The contact lens solution according to claim 1, characterized in that, The complexing agent comprises, by weight parts: 0.01-2 parts of trisodium citrate, 0.01-2 parts of poloxamer 407, and 0.01-0.5 parts of disodium edetate.

6. The contact lens solution according to claim 1, characterized in that, The antibacterial agent is polyhexamethylene biguanide hydrochloride.

7. A method for preparing a contact lens care solution as described in any one of claims 1-6, characterized in that, include: Hydroxypropyl methylcellulose, polyvinylpyrrolidone, modified ectoine, complexing agent and antibacterial agent are dissolved in the purified water according to the specified ratio to obtain a mixed solution; Add a pH adjuster to the mixed solution to adjust the pH to 6.7-7.7, and add an osmotic pressure adjuster to adjust the osmotic pressure to 260-340 mosm / kg. H2O is used to obtain contact lens solution.

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