Antidotal composition, preparation method and application thereof

Abstract

The present invention belongs to the technical field of hangover relief, and particularly relates to a hangover composition, which comprises component A, component B and component C. Among them, the component A contains NAD source and / or NAD precursor component, and the component B is freeze-dried powder and / or extract of banana; the component C is oxidized glutathione; the extract is the component obtained by freeze-drying the banana after ultrasonic-assisted water extraction. Among them, the temperature in the water extraction stage is controlled below 45°C; the banana refers to the pulp and / or peel of the banana. The components of the present invention have excellent hangover activity, can effectively promote alcohol degradation, and reduce the risk of alcohol poisoning.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceuticals and relates to the technical field of hangover-relieving compositions. Background Art

[0002] Alcohol is a unique and captivating traditional beverage. In recent years, the number of alcoholics and alcohol poisoning cases in my country has been increasing, seriously impacting people's health, family, and social stability. Alcohol has a wide range of pharmacological effects on the human body. Acute, heavy drinking can cause nausea, vomiting, memory loss, difficulty concentrating, emotional instability, and, in severe cases, even death due to respiratory muscle paralysis. Therefore, the development of effective alcohol detoxification drugs is of paramount importance and is receiving widespread attention and concern.

[0003] Alcohol that enters the mouth enters the intestines via the esophagus. Absorption in the stomach and intestines accounts for 25% and 75%, respectively, with the rate and proportion of absorption slightly dependent on the presence of food in the stomach. The absorbed alcohol enters the bloodstream unchanged, where it is affected, increasing blood viscosity and dramatically raising blood pressure, potentially contributing to cardiovascular risk. During this period, a large amount of alcohol entering the bloodstream first reaches the liver via the portal vein, where it is metabolized. Excess alcohol, which exceeds the liver's metabolic capacity, flows through the right side of the heart. The right side of the heart contracts, pumping alcohol into the lungs. Approximately 5% of this alcohol crosses the respiratory membranes and is excreted from the body through the respiratory tract, where it is transferred from the venous bloodstream into the fast-track arterial bloodstream. Meanwhile, approximately 5% of the alcohol that passes through the kidneys is filtered and excreted in the urine. Over 80% of alcohol is metabolized in the liver. The liver metabolizes alcohol in three main steps: ① Alcohol dehydrogenase converts alcohol into acetaldehyde; ② Acetaldehyde dehydrogenase converts acetaldehyde into acetic acid; ③ Through the biochemical reactions of the tricarboxylic acid cycle, acetic acid is converted into carbon dioxide and water for excretion. However, liver metabolism is a lengthy process, requiring approximately 12 hours or more for most of the alcohol in the body to be completely metabolized and blood alcohol concentration to return to normal.

[0004] Currently, clinical treatment for acute alcohol poisoning typically involves intravenous infusions of glucose, vitamin B1, vitamin B6, and niacin to accelerate ethanol metabolism. In severe cases, intravenous naloxone is administered to promote recovery of consciousness by inhibiting respiratory and cardiovascular function, thereby blocking the central nervous system depression caused by alcohol poisoning. While these treatments are rapid and effective, they require transporting the intoxicated individual to a hospital for treatment, which is extremely inconvenient.

[0005] The currently common way to relieve alcohol intoxication is to take oral anti-alcoholism drugs, including chemical drugs, traditional Chinese medicine preparations and other types. Drug-type anti-alcoholism drugs, especially those containing chemical components, often cause metabolic burden on the human liver and kidneys while relieving alcohol intoxication, resulting in varying degrees of harm. Therefore, it is not the best choice. Although traditional Chinese medicine anti-alcoholism drugs have relatively high safety, their preparation process is complex, the effect is slow to take effect, the dosage is large, and the taste is not very good. Summary of the Invention

[0006] Aiming at the existing problems, the first object of the present invention is to provide an anti-alcoholism composition, aiming to provide an active combination component that is safe and has excellent anti-alcoholism effects.

[0007] The second object of the present invention is to provide the anti-alcoholism composition as described above and its application in the preparation of anti-alcoholism products.

[0008] The third object of the present invention is to provide a product containing the anti-alcoholism composition.

[0009] An anti-alcoholism composition includes component A, component B and component C. Among them, the component A contains NAD source and / or NAD precursor component, and the component B is freeze-dried powder and / or extract of banana; component C is oxidized glutathione (also known as GSSH);

[0010] The extract is the component obtained by freeze-drying the banana after ultrasonic-assisted water extraction, and the temperature in the water extraction stage is controlled below 45°C;

[0011] The banana refers to the pulp and / or peel of the banana.

[0012] In the present invention, innovatively combining component A, component B and component C can unexpectedly achieve synergy, can improve the metabolism of alcohol from multiple dimensions, and then effectively promote the metabolism efficiency and effect of alcohol, and can effectively relieve alcohol poisoning symptoms.

[0013] In the present invention, the NAD refers to β-nicotinamide adenine dinucleotide.

[0014] In the present invention, in the component A, the NAD source is an NAD compound and / or a material containing an NAD compound. For example, the material containing an NAD compound is yeast extract;

[0015] In the present invention, the NAD precursor component includes at least one of nicotinamide riboside and β-nicotinamide mononucleotide. The β-nicotinamide mononucleotide is also called NMN. The nicotinamide riboside is also called NR.

[0016] In the present invention, the component A includes a NAD source and NAD precursor components, and the NAD precursor components include nicotinamide ribose and β-nicotinamide mononucleotide. In the present invention, preferably, the combination of component A, the component B and the component C can unexpectedly obtain a better synergistic effect, and can further improve the alcohol metabolism effect and efficiency.

[0017] In the present invention, in the component A, the weight ratio of the NAD source to the NAD precursor components is 1-2:1-5; in the NAD precursor components, the weight ratio of nicotinamide ribose to β-nicotinamide mononucleotide is 1-2:1-2.

[0018] More preferably, the component A includes a NAD source, nicotinamide ribose and β-nicotinamide mononucleotide, and their weight ratio is 1:1-1.5:1-1.5.

[0019] In the present invention, the combination of the freeze-dried powder of banana, its low-temperature extract assisted by ultrasonic wave and components A and C can unexpectedly show excellent alcohol metabolism promoting effect. And the ultrasonic low-temperature assisted extract can unexpectedly obtain a better alcohol metabolism promoting advantage.

[0020] In the present invention, the temperature in the water extraction stage is 5-40°C, and more preferably 5-25°C;

[0021] Preferably, the liquid-solid ratio in the water extraction stage is 5-10 mL / g;

[0022] Preferably, the ultrasonic power in the water extraction stage is 1000-1300 W;

[0023] Preferably, the water extraction time is more than 0.5 h. Considering the treatment efficiency and effect, it can be 0.5-2 h, and further can be 1-1.5 h.

[0024] Preferably, the extraction times are more than 3 times.

[0025] In the present invention, the extraction solution after water extraction is freeze-dried to obtain the extract.

[0026] In the present invention, the component B is the freeze-dried powder of banana peel and its extract. The research of the present invention also unexpectedly shows that the use of the freeze-dried powder of banana peel and its extract can unexpectedly show a better alcohol metabolism promoting effect.

[0027] In the present invention, in the anti-alcoholism composition: the weight ratio of component A: component B and component C is 1-10:5-15:1-3, further 3-6:7-14:1-2; more further 3-4:7-10:1-1.5.

[0028] The present invention also provides a preparation method of the hangover-relieving composition, which is obtained by compounding Component A, Component B and Component C;

[0029] Preferably, bananas are pre-freeze-dried or extracted with water assisted by ultrasound to obtain Component B, and then mixed with Component A and Component C to obtain the composition.

[0030] The present invention also provides an application of the hangover-relieving composition, which is prepared for preparing products with hangover-relieving functions. Preferably, the products are medicines and / or health products.

[0031] In the present invention, a hangover-relieving product is also provided, which contains the hangover-relieving composition.

[0032] In the present invention, the hangover-relieving product contains food and excipients allowed to be added in medicines; including but not limited to at least one of solvents, propellants, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, antiadhesives, chelating agents, penetration enhancers, pH regulators, buffers, plasticizers, surfactants, foaming agents, defoaming agents, thickeners, clathrates, humectants, absorbents, diluents, flocculants and deflocculants, filter aids, release retardants; further being one or several of fumaric acid, lactic acid, isomaltitol, D-mannitol, compound esters of nipagin, magnesium stearate, xylitol, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, magnesium hydroxide, pregelatinized starch, calcium sulfate, fumed silica;

[0033] There is no special requirement for the weight ratio of the excipients to the hangover-relieving composition, for example, it can be 1-2:1;

[0034] In the present invention, the hangover-relieving product has any available form. For example, it can be an oral preparation, and further can be at least one of capsules, soft capsules, microcapsules, granules, syrups, mixtures, ordinary tablets, dispersible tablets, effervescent tablets, orally disintegrating tablets, lozenges, chewable tablets, solutions;

[0035] In the present invention, the hangover-relieving product is a medicine or a health product.

[0036] Beneficial effects:

[0037] The present invention innovatively combines Component A to Component C, which can unexpectedly achieve synergy, can improve alcohol metabolism from multiple dimensions, and further effectively promote the metabolism efficiency and effect of alcohol, and can effectively relieve alcohol poisoning symptoms. In addition, further using the freeze-dried powder and extract of banana peel as Component B, its combination with Component A and Component C can unexpectedly further synergistically improve the metabolism efficiency and effect of alcohol.

[0038] The anti-hangover composition described in the present invention has safe and reliable components and excellent solution effects. Description of the Drawings

[0039] Figure 1 It is the gas chromatogram for ethanol detection in the animal model experiment of the active ingredient group in Example 4, Example 1.

[0040] Specific Embodiment Modes

[0041] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts fall within the protection scope of the present invention.

[0042] The yeast extract is obtained by the following conventional steps according to the process reported in the literature "Research on the Production Process of Yeast Extract": yeast fermentation - cell disruption - solid-liquid separation - protein removal - concentration - spray drying.

[0043] In the present invention, the NAD content of the yeast extract is 20 - 25%. And in the following cases, the dosage of the yeast extract used is based on the weight of NAD.

[0044] In the following cases, unless otherwise specified for banana peel, other recorded banana raw materials are defaulted to the whole banana raw materials including the peel and pulp.

[0045] In the following cases, unless otherwise specified, the ultrasonic power of the ultrasonic treatment is 1000 - 1100W. The liquid-solid ratio in the extraction stage is typically listed as 6 - 7 ml / g.

[0046] In the following tests of the production effect of acetic acid, unless otherwise specified, they all refer to the average value of the parallel groups.

[0047] Example 1:

[0048] Nicotinamide riboside (NR), β-nicotinamide mononucleotide (NMN), yeast extract (weight based on NAD), oxidized glutathione (GSSH), and an additive (in this case, banana freeze-dried powder, which is a component obtained by freeze-drying and pulverizing the whole banana with the peel) are mixed in a ratio of 1:1:1:1.5:7 to obtain an anti-hangover active composition, which is added to the reaction system.

[0049] Comparative Example 1

[0050] Compared with Example 1, the only difference is that the additive is changed, and the experimental groups are as follows:

[0051] Control Group 1a: The additive is pomegranate freeze-dried powder;

[0052] Control group 1b: The additive is the freeze-dried powder of watermelon pulp;

[0053] Control group 1c: The additive is the freeze-dried powder of apple pulp;

[0054] Control group 1d: The additive is the freeze-dried powder of pitaya pulp;

[0055] Control group 1e: The additive is the freeze-dried powder of orange pulp;

[0056] Reaction system: Take 21 100-ml stoppered Erlenmeyer flasks, with three in each group (i.e., three parallel groups), and add 5 ml of ethanol, 10 ml of 0.1 mol / L phosphate buffer at pH 7.0, 100 u of alcohol dehydrogenase, and 100 u of aldehyde dehydrogenase respectively.

[0057] Then add 500 mg of each of the above-mentioned mixed samples, place them in a shaker at 36 °C and shake for 2 hours, detect the concentration of acetic acid generated in the solution, and at the same time set up a blank control group.

[0058] Detection method: High performance liquid chromatography (HPLC-UV)

[0059] Chromatographic column: AQ-C18, 4.6×200 mm, 5 μm

[0060] Mobile phase: Phosphoric acid aqueous solution adjusted to pH 2.0 with phosphoric acid, adding 1% methanol

[0061] Wavelength: 210 nm

[0062] Flow rate: 1 ml / min

[0063] Column temperature: 25 °C

[0064] The results of the in vitro experiments of each group in Example 1 and Comparative Example 1 are shown in Table 1:

[0065] Table 1

[0066] Experimental group Generated concentration of acetic acid (mg / ml) Blank control group 0 Example 1 34.89 Control group 1a 3.75 Control group 1b 2.19 Control group 1c 2.25 Control group 1d 2.65 Control group 1e 1.05

[0067] It can be seen that using the freeze-dried powder of banana can unexpectedly show excellent ethanol degradation promotion effect.

[0068] Example 2

[0069] Compared with Example 1, the type of additive is changed, and the experimental groups are as follows:

[0070] Experimental group 2A: The additive is Extract A, which is the powder obtained by concentrating and freeze-drying the extract of banana raw material cut segments extracted by ultrasonic-assisted water (extraction temperature is 40 °C) for 1 h.

[0071] Experimental group 2B: The additive is extract B, which is a powder obtained by concentrating and freeze-drying the extract obtained by extracting cut banana raw materials with water (extraction temperature is 10 °C) assisted by ultrasound for 1 hour;

[0072] Experimental group 2C: The additive is extract C, which is a freeze-dried powder of banana peel;

[0073] Experimental group 2D: The additive is extract D, which is a powder obtained by concentrating and freeze-drying the extract obtained by extracting banana peel with water (extraction temperature is 10 °C) assisted by ultrasound for 1 hour;

[0074] Control group 2a: The additive is extract a, which is a powder obtained by concentrating and freeze-drying the extract obtained by extracting cut banana raw materials with ethanol (extraction temperature is 40 °C);

[0075] Control group 2b: The additive is extract b, which is a powder obtained by concentrating and freeze-drying the extract obtained by extracting cut banana raw materials with 50% ethanol aqueous solution (extraction temperature is 40 °C);

[0076] Control group 2c: The additive is extract c, which is a powder obtained by concentrating and freeze-drying the extract obtained by extracting cut banana raw materials with 50% methanol aqueous solution (extraction temperature is 40 °C);

[0077] Control group 2d: The additive is the powder of banana after heating and drying;

[0078] Test according to the method of Example 1, and the results are shown in Table 2

[0079] Table 2

[0080] Experimental group Generated concentration of acetic acid (mg / ml) Experimental group 2A 37.89 Experimental group 2B 38.58 Experimental group 2C 43.26 Experimental group 2D 45.29 Control group 2a 2.21 Control group 2b 4.45 Control group 2c 4.56 Control group 2d 3.59

[0081] It can be seen from Table 2 that using low-temperature ultrasonic-assisted leaching of bananas can unexpectedly show better ethanol degradation effect. Further, using banana peel can unexpectedly further improve the ethanol degradation effect.

[0082] Example 3

[0083] Compared with Example 1, the components and proportions in the hangover composition are changed, and the case groups are:

[0084] Experimental group 3A: The weight ratio of nicotinamide riboside (NR), β-nicotinamide mononucleotide (NMN), yeast extract, oxidized glutathione (GSSH), and additive is 1.5:1.5:1:1:5;

[0085] Experimental group 3B: The weight ratio of nicotinamide riboside (NR), β-nicotinamide mononucleotide (NMN), yeast extract, oxidized glutathione (GSSH), and additive is 1:1:1:1.5:15;

[0086] Example 3C: Lack of nicotinamide riboside (NR) and β-nicotinamide mononucleotide (NMN), and the weight ratio of yeast extract, oxidized glutathione (GSSH), and additive is 3:1.5:7;

[0087] Perform the ethanol catalysis test according to the method of Example 1. During the test, the total amount of the anti-alcohol components added (calculated based on the active ingredients) is the same. The results are shown in Table 3:

[0088] Table 3

[0089] Experimental group Generated concentration of acetic acid (mg / ml) Experimental group 3A 31.25 Experimental group 3B 31.65 Experimental group 3C 30.58

[0090] Comparative Example 2

[0091] Compared with Example 1, the difference is only that the components in the composition are changed, and the specific groups are as follows:

[0092] Comparison Group 3a: Lack of oxidized glutathione (GSSH);

[0093] Comparison Group 3b: Lack of the additive;

[0094] Comparison Group 3c: Lack of nicotinamide riboside (NR), β-nicotinamide mononucleotide (NMN), yeast extract, oxidized glutathione (GSSH) (that is, single banana freeze-dried powder);

[0095] Perform the ethanol catalysis test according to the method of Example 1. During the test, the total amount of the anti-alcohol components added is the same. The results are shown in Table 4:

[0096] Table 4

[0097] Experimental group Generated concentration of acetic acid (mg / ml) Control group 3a 29.25 Control group 3b 3.45 Control group 3c 1.21

[0098] It can be seen from Table 3 and Table 4 that adjusting different compatibility ratios has a slight impact on the production of acetic acid. Lack of nicotinamide riboside (NR), β-nicotinamide mononucleotide (NMN), and oxidized glutathione (GSSH) has a relatively small impact on in vitro experiments; using the additive and the single component of banana powder alone cannot achieve a good anti-alcohol effect.

[0099] Example 4: Animal model study

[0100] Conduct animal model experiments on the above typical experimental groups (such as Example 1, Example 2B, Example 2C, Example 2D, Example 3A, Example 3B, Example 3C, Comparative 3a, Comparative 3b, Comparative 3c). The experimental process is as follows:

[0101] Mouse experimental model

[0102] Test sample: The above-mentioned anti-alcohol composition

[0103] 1) Experimental method: 100 mice, with 50 males and 50 females, weighing 180 - 220 g, were randomly divided into 7 groups according to gender and weight, with 10 mice in each group. They were respectively a blank control group, b model control group, c low-dose test substance group (10 mg / kg), d medium-dose test substance group (20 mg / kg), and e high-dose test substance group (30 mg / kg).

[0104] Gavage administration was carried out according to the designed dosage. The blank control group and the model group were given 20 mg / kg of water. 30 minutes after administration, except for the blank control group, each group was given 15 ml / kg of KaiKouXiao liquor at 50.8 degrees. Blood was collected by eye socket puncture 1 hour later.

[0105] 2) Gas phase conditions for detecting ethanol content in the reaction solution and serum samples

[0106] Chromatographic column: HP-5 column (25 m * 0.32 mm, 0.52 μm 5% phenyl polysiloxane cross-linked column, produced by Agilent)

[0107] Column head pressure: 75 kPa

[0108] Carrier gas: N2

[0109] Injection volume: 100 μl

[0110] Injection port temperature: 150 °C, Detector temperature: 220 °C, Column temperature: 50 °C

[0111] Split ratio: 50:1

[0112] Internal standard: n-butanol

[0113] 3) Sample detection

[0114] About 0.8 ml of blood was collected by eye socket puncture 1 hour later. After heparin anticoagulation treatment, 0.1 ml was taken into a headspace vial with a stopper at the top. 1.0 ml of the internal standard solution was precisely added, and distilled water was added dropwise to the scale of the headspace bottle. It was heated in a water bath at 80 °C for 20 minutes, and 100 μl of the top air was extracted with a microsyringe for injection and determination.

[0115] 4) Experimental results

[0116] The results are shown in Table 5:

[0117] Table 5

[0118]

[0119] As shown in Table 5, compared with the blank control group, the ethanol content in the blood of the model group was significantly increased in Example 1, Example 2B, Example 2C, Example 2D, Example 3A, Example 3B, Example 3C, Comparative Example 3a. Compared with the model group, the ethanol content in the blood of the test dose groups was significantly decreased, and the high-dose test group < the medium-dose test group < the low-dose test group; compared with the blank control group, the ethanol content in the blood of the model group was significantly increased in Comparative Example 3b and Comparative Example 3c. Compared with the model group, the decrease in the ethanol content in the blood of the test dose groups was less, and the ethanol degradation effect was not obvious.

[0120] In addition, through the combination of the components described in the present invention, synergy can be unexpectedly achieved, and under the same dosage, a better synergistic ethanol degradation effect can be unexpectedly obtained.

[0121] The above are only the preferred embodiments of the present invention, and do not limit the present invention in any way. Any simple modifications, changes, and equivalent exchanges made to the above embodiments based on the technical essence of the present invention still belong to the protection scope of the technical solution of the present invention.

Claims

1. An anti-hangover composition, characterized in that: It is composed of component A, component B and component C. Among them, the said component A contains NAD source and NAD precursor components, the said component B is freeze-dried powder and / or extract of banana; component C is oxidized glutathione; The said extract is the component obtained by freeze-drying the banana after ultrasonic-assisted water extraction, where the temperature in the water extraction stage is 10~40°C; The said banana refers to the whole banana raw material including peel and pulp, and / or banana peel; The said NAD source is yeast extract; The said NAD precursor components include nicotinamide riboside and β-nicotinamide mononucleotide.

2. The anti-hangover composition according to claim 1, characterized in that: In the said component A, the weight ratio of NAD source to NAD precursor components is 1~2:1~5; in the NAD precursor components, the weight ratio of nicotinamide riboside to β-nicotinamide mononucleotide is 1~2:1~2.

3. The anti-hangover composition according to claim 1, wherein: In the said component B, the temperature in the water extraction stage is 10~25°C.

4. The hangover-relieving composition according to claim 1, wherein: The liquid-solid ratio in the water extraction stage is 5~10 mL / g.

5. The hangover-relieving composition according to claim 1, wherein The ultrasonic power in the water extraction stage is 1000~1300 W.

6. The hangover-relieving composition according to claim 1, wherein The time of water extraction is more than 0.5 h.

7. The anti-hangover composition according to claim 1, wherein, The number of water extraction times is more than 3 times.

8. The hangover-relieving composition according to claim 1, wherein: The said component B is freeze-dried powder of banana peel and its extract.

9. The anti-hangover composition according to any one of claims 1 to 8, characterized in that: The weight ratio of component A, component B and component C is 1~10:5~15:1~3.

10. The hangover-relieving composition according to claim 9, wherein: The weight ratio of component A, component B and component C is 3~6:7~14:1~2.

11. The hangover-relieving composition according to claim 10, wherein: The weight ratio of component A, component B and component C is 3~4:7~10:1~1.

5.

12. A method for preparing the hangover-relieving composition according to any one of claims 1 to 11, characterized in that: Compound component A, component B and component C, and you will get it.

13. The preparation method of the hangover composition according to claim 12, wherein: Pre-freeze-dry the banana or perform ultrasonic-assisted water extraction to obtain component B, and then mix it with component A and component C, and you will get it.

14. Use of the hangover-relieving composition according to any one of claims 1 to 11, characterized in that: Use it to prepare products with the function of relieving alcohol.

15. Use of the hangover-relieving composition according to claim 14, characterized in that: The said products are drugs and / or health products.

16. An anti-hangover product, characterized in that, It contains the anti-alcoholism composition described in any one of claims 1~11.

17. The hangover-relieving product according to claim 16, characterized in that, It contains excipients allowed to be added in foods and drugs; the said excipients include at least one of propellants, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, lubricants, wetting agents, osmotic pressure regulators, glidants, flavoring agents, preservatives, suspending agents, anti-adhesives, chelating agents, penetration enhancers, pH regulators, plasticizers, foaming agents, defoaming agents, thickeners, clathrates, humectants, absorbents, diluents, flocculants, deflocculants, filter aids, release retardants.

18. The hangover-relieving product according to claim 17, wherein, The said excipients include one or several of fumaric acid, lactic acid, isomaltitol, D-mannitol, compound esters of nipagin, magnesium stearate, xylitol, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, magnesium hydroxide, pregelatinized starch, calcium sulfate, fumed silica.

19. The hangover-relieving product according to claim 17, wherein The weight ratio of the said excipients to the anti-alcoholism composition is 1~2:

1.

20. The hangover-relieving product according to any one of claims 16 to 19, wherein It is an oral preparation.

21. The hangover-relieving product according to claim 20, wherein, The anti-alcoholism products are at least one of capsules, granules, syrups, mixtures, ordinary tablets, dispersible tablets, effervescent tablets, orally disintegrating tablets, lozenges, chewable tablets.

22. The hangover-relieving product according to claim 16, wherein, The said anti-alcoholism products are drugs or health products.

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