A structure loaded with a target therapeutic drug and a preparation method thereof

Abstract

This invention discloses a structure and preparation method for loading targeted therapeutic drugs, relating to the field of targeted drug preparation. The invention includes a base, a battery, a preparation chamber, a conveyor belt, a drug delivery device, an electronic control panel, and a drug structure. The preparation chamber includes heating plates, with several heating plates disposed on one surface inside the preparation chamber body. The conveyor belt includes second nozzles, with one end of several second nozzles connected to the inside of a storage tank. The drug delivery device includes drug storage cylinders, with several drug storage cylinders disposed on the upper surface of the preparation chamber body. The electronic control panel includes a display screen, disposed on another surface of the panel body. The drug structure includes a first drug tube, with one end of the first drug tube connected to the inside of a lower outer shell. This invention provides a structure and preparation method for loading targeted therapeutic drugs, allowing for in vivo drug delivery through the first and second drug tubes; the heating plates accelerate material curing and molding.

Description

Technical Field

[0001] This invention relates to the field of targeted drug preparation, and in particular to a structure for loading a targeted therapeutic drug and its preparation method. Background Technology

[0002] Currently, many cancer drugs suffer from poor bioavailability due to non-specific biological distribution and targeting, poor water solubility, significant toxic side effects, and low oral bioavailability. Therefore, high-performance carriers are needed to improve the utilization of cancer drugs. Increasing drug targeting ability and improving drug water solubility and stability have become current research hotspots. With the rapid development of 3D printing technology, many 3D-printed special structures for targeted drug delivery have emerged.

[0003] Existing targeted drugs are difficult to penetrate deeper into the body, resulting in poor endurance. At the same time, the preparation process is complex, with high production efficiency and low cost. To address this, we propose a structure for loading targeted therapeutic drugs and its preparation method. Summary of the Invention

[0004] The main objective of this invention is to provide a structure for loading targeted therapeutic drugs and a method for preparing the same, which can effectively solve the problems in the prior art where targeted drugs are not easy to penetrate deeper into the body, resulting in poor endurance, and the preparation process is complex, with low output efficiency and low cost.

[0005] To solve the above-mentioned technical problems, the present invention is achieved through the following technical solution: a structure for loading targeted therapeutic drugs and its preparation method, comprising a base, a battery, a preparation chamber, a conveyor belt, a drug delivery device, an electronic control panel, and a drug structure. The base includes a base body, support columns, and anti-slip pads. One end of each support column is connected to the lower surface of the base body, and the anti-slip pads are disposed at the other end of the support columns. The battery includes a battery body and a power supply port. The battery body is installed inside the base body, and the power supply port is disposed on one surface of the base body, which is connected to one surface of the battery body. The preparation chamber includes a preparation chamber body, a glass door, and a material drop frame. The preparation chamber body is installed on the upper surface of the base body, and the glass door is disposed on one surface of the preparation chamber body. The material drop frame is installed on another surface of the preparation chamber body. The conveyor belt includes a conveyor belt body, a mold groove, and a storage box. The conveyor belt body is installed inside the preparation chamber body. Several mold grooves are arranged on the upper surface of the conveyor belt body. The storage box is arranged on the upper surface of the preparation chamber body. The drug delivery device includes a drug delivery device body and a drug delivery tube. Several drug delivery device bodies are installed inside the preparation chamber body. One end of several drug delivery tubes is connected to the lower surface of the drug delivery device body. The electronic control panel includes a panel body and a rotating shaft. The circumferential side of the rotating shaft is arranged on another surface of the preparation chamber body. One surface of the panel body is connected to the circumferential side of the rotating shaft. The drug structure includes a lower outer shell and an upper outer shell. The lower surface of the upper outer shell is provided with a through hole. The upper surface of the lower outer shell is adapted to the interior of the through hole.

[0006] Preferably, the base further includes a collection groove and slide rails. Several slide rails are disposed inside the base body, and the collection groove is installed inside the base body. Each surface of the collection groove has a slider, and the slider slides in cooperation with the circumferential side of the slide rail. The purpose of collecting scattered objects is achieved by setting the collection groove.

[0007] Preferably, the battery further includes an electronic control system, which is located inside the base body. By setting up the electronic control system, the purpose of centrally controlling the backup device equipment system can be achieved.

[0008] Preferably, the preparation chamber further includes a collection port and a cleaning brush. The collection port is located inside the preparation chamber body, and one surface of the cleaning brush slides in conjunction with the inside of the preparation chamber body. By setting the cleaning brush, the purpose of cleaning the inside of the preparation chamber is achieved so that scattered materials can enter the collection tank.

[0009] Preferably, the preparation chamber further includes heating plates, and several heating plates are disposed on an inner surface of the preparation chamber body. By setting the heating plates, the purpose of heating and drying can be achieved to accelerate the solidification of the raw materials.

[0010] Preferably, the conveyor belt further includes a first nozzle, and one end of a plurality of the first nozzles is disposed inside the storage bin. By setting the first nozzles, the purpose of producing the lower outer shell structure is achieved.

[0011] Preferably, the conveyor belt further includes a second nozzle and a tube mold. One end of the second nozzle is connected to the inside of the storage box, and one end of the tube mold is connected to the other end of the second nozzle. By setting the tube mold, the purpose of assisting in the forming of drug tubes is achieved.

[0012] Preferably, the drug delivery device further includes a drug storage cylinder and a sealing device. Several drug storage cylinders are disposed on the upper surface of the preparation chamber body, and the upper surface of the drug delivery device body is connected to the inside of the drug storage cylinder. Several sealing devices are installed inside the preparation chamber body. By setting the sealing devices, the purpose of sealing the drug structure is achieved.

[0013] Preferably, the electronic control panel further includes a display screen and control buttons. The display screen is disposed on another surface of the panel body, and a plurality of control buttons are installed on another surface of the panel body, so as to operate the preparation device system by setting the display screen in conjunction with the control buttons.

[0014] Preferably, the drug structure further includes a first drug tube and a second drug tube. One end of the first drug tube is connected to the inside of the lower outer shell, and one end of each of the second drug tubes is connected to the inside of the lower outer shell. By setting the first drug tube, the purpose of delaying drug release for secondary drug administration is achieved.

[0015] The present invention has the following beneficial effects:

[0016] This invention achieves the effect of secondary drug delivery within the human body by setting up a multi-layered internal structure, thereby improving the drug's endurance and enabling the release of the drug deeper within the body.

[0017] This invention facilitates drug preparation by incorporating a curing material and a printing device.

[0018] This invention uses a heating plate to dry the materials inside the preparation chamber, accelerating their solidification and increasing the preparation speed.

[0019] Of course, any product implementing this invention does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0020] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0022] Figure 2 This is a front view of the present invention;

[0023] Figure 3 This is the left view of the present invention;

[0024] Figure 4 This is a top view of the present invention;

[0025] Figure 5 for Figure 2 Sectional view at point AA;

[0026] Figure 6 for Figure 3 Sectional view at BB;

[0027] Figure 7 This is a load structure diagram of the present invention;

[0028] Figure 8 for Figure 7 Sectional view at CC.

[0029] The attached diagram lists the components represented by each number as follows:

[0030] 100. Base; 101. Support column; 102. Anti-slip pad; 103. Collection trough; 104. Slide rail; 200. Battery; 201. Power supply port; 202. Electrical control system; 300. Preparation chamber; 302. Material drop frame; 303. Collection port; 304. Cleaning brush; 305. Heating plate; 400. Conveyor belt; 401. Mold trough; 402. First nozzle; 403. Second nozzle; 404. Tube mold; 405. Storage box; 500. Drug dispenser; 501. Drug delivery tube; 502. Drug storage cylinder; 503. Sealer; 600. Electrical control panel; 601. Display screen; 602. Control button; 603. Rotating shaft; 700. Drug structure; 701. Lower outer shell; 702. Upper outer shell; 703. First drug tube; 704. Second drug tube. Detailed Implementation

[0031] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0032] In the description of this invention, it should be noted that the terms "upper," "lower," "inner," "outer," "front end," "rear end," "both ends," "one end," and "the other end," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0033] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0034] See Figure 1-8 This invention relates to a structure for loading targeted therapeutic drugs, comprising a base 100, a battery 200, a preparation chamber 300, a conveyor belt 400, a drug delivery device 500, an electronic control panel 600, and a drug structure 700. The base 100 includes a base body, support columns 101, and anti-slip pads 102. One end of each support column 101 is connected to the lower surface of the base body, and the anti-slip pads 102 are disposed at the other end of each support column 101. The battery 200 includes a battery body and a power supply port 201. The battery body is installed inside the base body, and the power supply port 201 is disposed on one surface of the base body, with the surface of the power supply port 201 connected to the surface of the battery body. The preparation chamber 300 includes a preparation chamber body, a glass door, and a material drop frame 302. The preparation chamber body is installed on the upper surface of the base body, the glass door is disposed on one surface of the preparation chamber body, and the material drop frame 302 is installed on... Installed on the other surface of the preparation chamber body, the conveyor belt 400 includes a conveyor belt body, a mold groove 401, and a storage box 405. The conveyor belt body is installed inside the preparation chamber body, and several mold grooves 401 are set on the upper surface of the conveyor belt body. The storage box 405 is set on the upper surface of the preparation chamber body. The drug delivery device 500 includes a drug delivery device body and a drug delivery tube 501. Several drug delivery device bodies are installed inside the preparation chamber body, and one end of several drug delivery tubes 501 is connected to the lower surface of the drug delivery device body. The electronic control panel 600 includes a panel body and a rotating shaft 603. The peripheral side of the rotating shaft 603 is set on the other surface of the preparation chamber body, and one surface of the panel body is connected to the peripheral side of the rotating shaft 603. The drug structure 700 includes a lower outer shell 701 and an upper outer shell 702. The lower surface of the upper outer shell 702 is provided with a through hole, and the upper surface of the lower outer shell 701 is adapted to the interior of the through hole.

[0035] Please see Figure 6 The base 100 also includes a collection trough 103 and a slide rail 104. Several slide rails 104 are disposed inside the base body. The collection trough 103 is installed inside the base body. Each surface of the collection trough 103 has a slider. The slider slides in cooperation with the side of the slide rail 104. Specifically, the collection trough 103 is provided with a handle. The purpose of collecting scattered objects is achieved by setting the collection trough 103.

[0036] Please see Figure 6 The battery 200 also includes an electronic control system 202, which is located inside the base body. By setting up the electronic control system 202, the purpose of centrally controlling the backup device equipment system can be achieved.

[0037] Please see Figure 5 The preparation chamber 300 also includes a collection port 303 and a cleaning brush 304. The collection port 303 is located inside the preparation chamber body, and one surface of the cleaning brush 304 slides in cooperation with the inside of the preparation chamber body. By setting the cleaning brush 304, the purpose of cleaning the inside of the preparation chamber 300 is achieved so that the scattered objects enter the collection tank 103.

[0038] Please see Figure 2 The preparation chamber 300 also includes heating plates 305. Several heating plates 305 are disposed on a surface inside the preparation chamber body. By setting the heating plates 305, the purpose of heating and drying can be achieved to accelerate the solidification of raw materials.

[0039] Please see Figure 2 The conveyor belt 400 also includes a first nozzle 402. One end of each first nozzle 402 is disposed inside the storage box 405. Specifically, the first nozzle 402 has a telescopic lifting function. By setting the first nozzle 402, the purpose of producing the lower outer shell 701 structure is achieved.

[0040] Please see Figure 2 The conveyor belt 400 also includes second nozzles 403 and tube molds 404. One end of several second nozzles 403 is connected to the inside of the storage box 405, and one end of several tube molds 404 is connected to the other end of the second nozzles 403. Specifically, the second nozzles 403 have telescopic lifting functions, and the shapes of the tube molds 404 are respectively consistent with the shapes of the first drug tube 703 and the second drug tube 704. By setting the tube molds 404, the purpose of playing an auxiliary role in the forming of drug tubes is achieved.

[0041] Please see Figure 2The drug delivery device 500 also includes a drug storage cylinder 502 and a sealing device 503. Several drug storage cylinders 502 are disposed on the upper surface of the preparation chamber body, and the upper surface of the drug delivery device body is connected to the inside of the drug storage cylinders 502. Several sealing devices 503 are installed inside the preparation chamber body. By setting the sealing devices 503, the purpose of sealing the drug structure 700 is achieved.

[0042] Please see Figure 2 The electronic control panel 600 also includes a display screen 601 and control buttons 602. The display screen 601 is located on another surface of the panel body, and several control buttons 602 are installed on another surface of the panel body. Specifically, the control buttons 602 include a power button, a conveyor belt 400 speed adjustment button, and a nozzle operation button, so as to operate the preparation device system by setting the display screen 601 in conjunction with the control buttons 602.

[0043] Please see Figure 8 The drug structure 700 also includes a first drug tube 703 and a second drug tube 704. One end of the first drug tube 703 is connected to the inside of the lower outer shell 701, and one end of each of the second drug tubes 704 is connected to the inside of the lower outer shell 701. By setting the first drug tube 703, the purpose of delaying the release of the drug for secondary administration is achieved.

[0044] A method for preparing a targeted therapeutic drug, comprising the following steps:

[0045] When in use, the preparation device is placed on a flat surface. After powering the device through the power supply port 201, the preparation device is started by operating the control panel 600. At this time, the first nozzle 402 descends into the mold groove 401 on the conveyor belt 400 to form and print the lower outer shell 701. After the lower outer shell 701 is cured, the conveyor belt 400 starts to transport the lower outer shell 701 to the area below the second nozzle 403. At this time, the second nozzle 403 descends and prints the first drug tube 703 and the second drug tube 704 on the upper surface of the lower outer shell 701 through the tube mold 404. After the drug tubes are cured, the conveyor belt 400 moves them to the area below the drug delivery device 500. The drug powder is filled into the drug tube through the drug delivery tube 501. After the powder is filled, the upper outer shell 702 prepared in advance inside the sealing device 503 is connected to the lower outer shell 701 through the sealing device 503 to complete the closure. Finally, the conveyor belt 400 sends it out of the preparation chamber 300 and it falls into the material drop box 302 for collection.

[0046] Specifically, the drug tube can be made of starch-based drugs. Different drug powders are added according to the medication requirements. The proportion of drug powder is about 1%-2%. It is mixed with about 46% by weight of the disintegrant cross-linked polyvinylpyrrolidone and sodium bicarbonate, about 35% by weight of the filler lactose and starch, and about 18% by weight of the binder starch paste to form a viscous consistency that can be extruded and printed. The proportion of each component is slightly different depending on the amount of drug. The diameter of the first drug tube 703 needs to be larger than that of the second drug tube 704 so that it needs a longer time to decompose in the human body so that it can reach deeper through the stomach and dissolve and release the drug to achieve the effect of secondary drug delivery.

[0047] During the preparation process, the user can adjust the heating temperature of the heating plate 305 according to the raw material conditions to ensure rapid material curing. By rotating the shaft 603, the user can rotate the electronic control panel 600 to be flush with the glass door, so as to observe the internal preparation process while operating the system. By sliding the cleaning brush 304, the spilled material generated during the preparation in the preparation chamber 300 can be swept from the collection port 303 into the collection tank 103 for collection and cleaning.

[0048] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A structure for loading targeted therapeutic drugs, comprising a base (100), a battery (200), a preparation chamber (300), a conveyor belt (400), a drug delivery device (500), an electronic control panel (600), and a drug delivery structure (700), characterized in that: The base (100) includes a base body, support columns (101), and anti-slip pads (102). One end of each support column (101) is connected to the lower surface of the base body, and the anti-slip pads (102) are disposed at the other end of each support column (101). The battery (200) includes a battery body and a power supply port (201). The battery body is installed inside the base body, and the power supply port (201) is disposed on one surface of the base body. One surface of the power supply port (201) is connected to one surface of the battery body. The preparation chamber (300) includes a preparation chamber body, a glass door, and a material drop frame (302). The preparation chamber body is installed on the upper surface of the base body, the glass door is disposed on one surface of the preparation chamber body, and the material drop frame (302) is installed on the other surface of the preparation chamber body. The conveyor belt (400) includes a conveyor belt body, a mold groove (401), and a storage... The material bin (405) is installed inside the preparation chamber body. Several mold slots (401) are set on the upper surface of the conveyor belt body. The material storage bin (405) is set on the upper surface of the preparation chamber body. The drug delivery device (500) includes a drug delivery device body and a drug delivery tube (501). Several drug delivery device bodies are installed inside the preparation chamber body. One end of several drug delivery tubes (501) is connected to the lower surface of the drug delivery device body. The electronic control panel (600) includes a panel body and a rotating shaft (603). The circumferential side of the rotating shaft (603) is set on another surface of the preparation chamber body. One surface of the panel body is connected to the circumferential side of the rotating shaft (603). The drug structure (700) includes a lower outer shell (701) and an upper outer shell (702). The lower surface of the upper outer shell (702) is provided with a through hole. The upper surface of the lower outer shell (701) is adapted to the interior of the through hole. The conveyor belt (400) further includes a first nozzle (402), with one end of several first nozzles (402) disposed inside a storage bin (405); the conveyor belt (400) further includes a second nozzle (403) and a tube mold (404), with one end of several second nozzles (403) connected to the inside of the storage bin (405), and one end of several tube molds (404) connected to the other end of the second nozzles (403); the drug delivery device (500) further includes a drug storage cylinder (502) and a sealing device (503), with several drug storage cylinders (502) disposed on the upper surface of the preparation chamber body, and the upper surface of the drug delivery device body... The surface is connected to the inside of the drug storage cylinder (502), and several of the sealing devices (503) are installed inside the preparation chamber body; the electronic control panel (600) also includes a display screen (601) and control buttons (602), the display screen (601) is disposed on another surface of the panel body, and several of the control buttons (602) are installed on another surface of the panel body; the drug structure (700) also includes a first drug tube (703) and a second drug tube (704), one end of the first drug tube (703) is connected to the inside of the lower outer shell (701), and one end of several of the second drug tubes (704) is connected to the inside of the lower outer shell (701).

2. The structure of a targeted therapeutic drug according to claim 1, characterized in that: The base (100) also includes a collection groove (103) and a slide rail (104). Several slide rails (104) are disposed inside the base body. The collection groove (103) is installed inside the base body. Each surface of the collection groove (103) has a slider. The slider slides in cooperation with the side surface of the slide rail (104).

3. The structure of a targeted therapeutic drug according to claim 1, characterized in that: The battery (200) also includes an electronic control system (202), which is located inside the base body.

4. The structure of a targeted therapeutic drug according to claim 1, characterized in that: The preparation chamber (300) also includes a collection port (303) and a cleaning brush (304). The collection port (303) is located inside the preparation chamber body, and one surface of the cleaning brush (304) slides in cooperation with the inside of the preparation chamber body.

5. The structure of a targeted therapeutic drug according to claim 1, characterized in that: The preparation chamber (300) also includes heating plates (305), and a plurality of the heating plates (305) are disposed on an inner surface of the preparation chamber body.

6. A method for preparing a targeted therapeutic drug, employing the structure of the targeted therapeutic drug loaded according to any one of claims 1-5, characterized in that: Includes the following steps: After powering the device through the power supply port (201), the preparation device is started by operating the control panel (600). At this time, the first nozzle (402) descends into the mold groove (401) on the conveyor belt (400) to form and print the lower shell (701). After the lower shell (701) solidifies, the conveyor belt (400) starts to transport the lower shell (701) to below the second nozzle (403). At this time, the second nozzle (403) descends and prints the first drug on the upper surface of the lower shell (701) through the tube mold (404). After the material tube (703) and the second drug tube (704) have solidified, the conveyor belt (400) moves them to the bottom of the drug delivery device (500). The drug delivery tube (501) is filled with drug powder. After the powder is filled, the upper shell (702) and the lower shell (701) inside the sealing device (503) are connected to the sealing device (503) to complete the closure. Finally, the conveyor belt (400) sends them out of the preparation chamber (300) and they fall into the material drop box (302) for collection.

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