A medical bacteriostatic nursing gel and a preparation method thereof

Abstract

The application relates to the technical field of biological medicine, and particularly discloses a medical bacteriostatic nursing gel and a preparation method thereof. The medical bacteriostatic nursing gel comprises the following raw materials in parts by weight: chlorhexidine gluconate 1-5 parts, Chinese herbal medicine 4-20 parts, ethanol 50-70 parts, glycerol 2-8 parts, hydrogenated polyisobutylene 0.01-0.1 part, carbomer 0.15-0.5 part and triethanolamine 0.2-0.7 part. The preparation method of the medical bacteriostatic nursing gel comprises the following steps: S1, the Chinese herbal medicine is extracted by using ethanol, the filtrate is mixed with glycerol after filtration, and the components except carbomer and triethanolamine are added and uniformly mixed, ultrasonic dispersion is carried out to obtain a mixed solution I; S2, the carbomer is added into the mixed solution I and stirred, and the gel is obtained after overnight standing; and S3, the triethanolamine is added into the gel and stirred, and the pH is adjusted to obtain the medical bacteriostatic nursing gel. The medical bacteriostatic nursing gel prepared by the application is mild and non-irritating, and has good bacteriostatic effect.

Description

Technical Field

[0001] This application relates to the field of biomedical technology, and in particular to a medical antibacterial nursing gel and its preparation method. Background Technology

[0002] As the largest organ in the human body, the skin covers the entire body, protecting various tissues and organs from physical, mechanical, chemical, and pathogenic microbial attacks. The skin has two barrier functions: firstly, it prevents the loss of water, electrolytes, and other substances from the body; secondly, it prevents the invasion of harmful external substances.

[0003] Nursing gels, as a special type of gel product, are primarily used by patients undergoing radiotherapy and chemotherapy. After these treatments, patients are physically weak, and any invasion of pathogens can pose a fatal risk. Ordinary nursing gels only aim to provide comfort and do not consider antibacterial properties. Therefore, it is possible to develop an antibacterial nursing gel that, while caring for the skin, also inhibits or kills the growth of bacteria. Summary of the Invention

[0004] In order to solve at least one of the above-mentioned technical problems and to develop a mild, non-irritating, and effective antibacterial nursing gel, this application provides a medical antibacterial nursing gel and its preparation method.

[0005] On the one hand, the medical antibacterial nursing gel provided in this application comprises the following raw materials in parts by weight per 100 parts: 1-5 parts chlorhexidine gluconate, 4-20 parts traditional Chinese medicine, 50-70 parts ethanol, 2-8 parts glycerin, 0.01-0.1 parts hydrogenated polyisobutylene, 0.15-0.5 parts carbomer, 0.2-0.7 parts triethanolamine, and the balance being deionized water;

[0006] The Chinese herbal medicines mentioned are calendula, centella asiatica, and sophora flavescens.

[0007] By adopting the above technical solutions, the medical antibacterial care gel of this application uses chlorhexidine gluconate and traditional Chinese medicine as the main antibacterial ingredients, which can kill various bacteria, fungi and some viruses. Hydrogenated polyisobutylene has good moisturizing properties, which helps to form a protective film on the skin surface, slows down water evaporation, and thus maintains the skin's moisture balance. It can also improve the stability of the medical antibacterial care gel, help maintain the uniform distribution of other ingredients in the formula, and extend the product's shelf life. Triethanolamine can act as an emulsifier, which helps to mix oily and watery ingredients, ensures the uniform distribution of raw materials and the texture of the medical antibacterial care gel, and can also act as a pH regulator to ensure that the medical antibacterial care gel is in the appropriate pH range, which helps the medical antibacterial care gel to fully exert its performance.

[0008] Optional, the medical antibacterial care gel, per 100 parts by weight, comprises the following raw materials: 2-4 parts chlorhexidine gluconate, 8-16 parts traditional Chinese medicine, 56-67 parts ethanol, 4-6 parts glycerin, 0.03-0.07 parts hydrogenated polyisobutylene, 0.25-0.35 parts carbomer, 0.3-0.5 parts triethanolamine, and the balance being deionized water.

[0009] Optionally, the weight ratio of calendula, centella asiatica and sophora flavescens is (5-7):(4-6):(3-4.8).

[0010] By adopting the above technical solution, the medical antibacterial care gel of this application uses calendula, centella asiatica and sophora flavescens as traditional Chinese medicine ingredients. Calendula, centella asiatica and sophora flavescens all have antibacterial and anti-inflammatory effects, which help prevent and treat skin infections, reduce skin inflammation, and reduce the irritation of ethanol to the skin. Calendula, centella asiatica and sophora flavescens contain compounds with antioxidant properties, which help fight free radical damage and maintain skin health. The three ingredients work together to enhance the comprehensive antibacterial effect of the medical antibacterial care gel.

[0011] Optionally, the weight ratio of chlorhexidine gluconate to traditional Chinese medicine is 1:(2.9-4.2).

[0012] By adopting the above technical solution, this application limits the dosage ratio between chlorhexidine gluconate and traditional Chinese medicine, which can optimize the performance of medical antibacterial care gel and help improve the antibacterial efficacy of medical antibacterial care gel.

[0013] Optionally, the weight ratio of carbomer to triethanolamine is 1:(1-2).

[0014] By adopting the above technical solution, this application limits the dosage ratio between carbomer and triethanolamine, which helps to improve the stability and skin adaptability of medical antibacterial care gel, and allows users to obtain better skin sensation.

[0015] Optionally, the raw materials for the medical antibacterial care gel may also include 0.04-0.07 parts by weight of modified nano-silver.

[0016] Optionally, the modified nano-silver can be prepared by adding an equal volume of 3-5 g / L sodium hydroxide solution to a 0.5-0.7 g / L dopamine hydrochloride solution and stirring. Then, add an equal volume of 1-3 g / L silver nitrate solution to the dopamine hydrochloride solution and stir thoroughly. After centrifuging the solution, a precipitate is obtained. The precipitate is washed and dried to obtain the modified nano-silver.

[0017] By adopting the above technical solution, this application also adds modified nano-silver, which is dopamine-modified nano-silver. This modified nano-silver can enhance the stability of nano-silver, increase antibacterial sites, improve dispersibility, and regulate the release rate to avoid premature release that would cause the antibacterial activity to disappear too quickly, thereby improving the antibacterial activity of nano-silver and thus improving the antibacterial performance of the medical antibacterial nursing gel.

[0018] Optionally, the particle size of the modified silver nanoparticles is 10-20 nm.

[0019] Secondly, this application provides a method for preparing the above-mentioned medical antibacterial nursing gel, comprising the following steps:

[0020] S1. Extract the Chinese herbal medicine with ethanol, filter to obtain the extract, stir and mix the extract with glycerin, add other components except carbomer and triethanolamine, stir and mix, disperse with ultrasonication to obtain mixture I.

[0021] S2. Add carbomer to mixture I and stir. Let stand overnight to obtain a colloid.

[0022] S3. Add triethanolamine to the colloid and stir, adjust the pH to obtain the medical antibacterial care gel.

[0023] By adopting the above technical solution, the medical antibacterial care gel prepared by this application with traditional Chinese medicine and chlorhexidine gluconate as the main antibacterial components has good antibacterial effect, good skin feel, and the preparation method is simple and easy to operate.

[0024] Optionally, the pH can be adjusted to 6.7-7 in step S3.

[0025] In summary, the present invention has at least one of the following beneficial technical effects:

[0026] 1. The medical antibacterial care gel of this application uses chlorhexidine gluconate and traditional Chinese medicine as the main antibacterial ingredients, which can kill various bacteria, fungi and some viruses; hydrogenated polyisobutylene has good moisturizing properties, which helps to form a protective film on the skin surface, slows down water evaporation, thereby maintaining the skin's moisture balance, and can also improve the stability of the medical antibacterial care gel, help maintain the uniform distribution of other ingredients in the formula, and extend the product's shelf life; triethanolamine can act as an emulsifier, which helps to mix oil and water components, ensures the uniform distribution of raw materials and the texture of the medical antibacterial care gel, and can also act as a pH regulator to ensure that the medical antibacterial care gel is in the appropriate pH range, which helps the medical antibacterial care gel to fully exert its performance.

[0027] 2. The medical antibacterial care gel of this application uses calendula, centella asiatica and sophora flavescens as traditional Chinese medicine ingredients and limits the dosage ratio of the three. Calendula, centella asiatica and sophora flavescens all have antibacterial and anti-inflammatory effects, which help prevent and treat skin infections, reduce skin inflammation, and reduce the irritation of ethanol to the skin. Calendula, centella asiatica and sophora flavescens contain compounds with antioxidant properties, which help fight free radical damage and maintain skin health. The three ingredients work together to enhance the comprehensive antibacterial effect of the medical antibacterial care gel.

[0028] 3. This application also adds modified nano-silver, which is dopamine-modified nano-silver, which can enhance the stability of nano-silver, increase antibacterial sites, improve dispersibility, and regulate the release rate to avoid premature release that would cause the antibacterial activity to disappear too quickly, thereby improving the antibacterial activity of nano-silver and thus improving the antibacterial performance of medical antibacterial nursing gel.

[0029] 4. The medical antibacterial care gel prepared by this application using traditional Chinese medicine and chlorhexidine gluconate as the main antibacterial components has good antibacterial effect, good skin feel, and the preparation method is simple and easy to operate. Detailed Implementation

[0030] The present application will be further described in detail below with reference to the embodiments.

[0031] This application designs a medical antibacterial nursing gel, which, based on 100 parts by weight, comprises the following raw materials: 1-5 parts chlorhexidine gluconate, 4-20 parts traditional Chinese medicine, 50-70 parts ethanol, 2-8 parts glycerin, 0.01-0.1 parts hydrogenated polyisobutylene, 0.15-0.5 parts carbomer, 0.2-0.7 parts triethanolamine, and the balance being deionized water;

[0032] The Chinese herbal medicines mentioned are calendula, centella asiatica, and sophora flavescens.

[0033] The medical antibacterial nursing gel of this application is prepared by the following method, including the following steps:

[0034] S1. Extract the Chinese herbal medicine with ethanol, filter to obtain the extract, stir and mix the extract with glycerin, add other components except carbomer and triethanolamine, stir and mix, disperse with ultrasonication to obtain mixture I.

[0035] S2. Add carbomer to mixture I and stir. Let stand overnight to obtain a colloid.

[0036] S3. Add triethanolamine to the colloid and stir, adjust the pH to obtain the medical antibacterial care gel.

[0037] The medical antibacterial care gel of this application uses chlorhexidine gluconate and traditional Chinese medicine as the main antibacterial ingredients, which can kill various bacteria, fungi and some viruses. Hydrogenated polyisobutylene has good moisturizing properties, which helps to form a protective film on the skin surface, slows down water evaporation, and thus maintains the skin's moisture balance. It can also improve the stability of the medical antibacterial care gel, help maintain the uniform distribution of other ingredients in the formula, and extend the product's shelf life. Triethanolamine can act as an emulsifier, which helps to mix oil and water components, ensures the uniform distribution of raw materials and the texture of the medical antibacterial care gel, and can also act as a pH regulator to ensure that the medical antibacterial care gel is in the appropriate pH range, which helps the medical antibacterial care gel to fully exert its performance. Specific Implementation

[0039] Chlorhexidine gluconate: CAS No.: 18472-51-0, purity: 19-21%;

[0040] Ethanol: Purity: 95%;

[0041] Glycerol: Purity: 99%;

[0042] Hydrogenated polyisobutylene: CAS No.: 68937-10-0, Wuhan Lanabai Pharmaceutical Chemical Co., Ltd.;

[0043] Carbomer: Carbomer 940-2; Hangzhou Renyu Cosmetics Factory;

[0044] Triethanolamine: CAS No.: 102-71-6;

[0045] Nano silver: CAS No.: 7440-22-4, Jiangsu Xianfeng Nanomaterials Technology Co., Ltd.;

[0046] Dopamine hydrochloride: CAS No.: 62-31-7, Hangzhou Weibaolai Biotechnology Co., Ltd.

[0047] Examples 1-5

[0048] Example 1

[0049] A medical antibacterial nursing gel comprises the following raw materials in a total weight of 100 kg: 1 kg chlorhexidine gluconate, 4 kg Chinese herbal medicine, 50 kg ethanol, 2 kg glycerin, 0.01 kg hydrogenated polyisobutylene, 0.15 kg carbomer, 0.2 kg triethanolamine, and the balance deionized water; wherein the Chinese herbal medicine is calendula, centella asiatica, and sophora flavescens in a weight ratio of 5:4:3.

[0050] The preparation method of medical antibacterial nursing gel includes the following steps:

[0051] S1. Extract the Chinese herbal medicine with ethanol, filter to obtain the extract, stir and mix the extract with glycerin, add other components except carbomer and triethanolamine, stir and mix, disperse with ultrasonication to obtain mixture I.

[0052] S2. Add carbomer to mixture I, stir slowly, and let stand overnight to obtain a colloid;

[0053] S3. Add triethanolamine to the colloid and stir slowly to adjust the pH to 6.7 to obtain the medical antibacterial care gel.

[0054] The difference between Examples 2-5 and Example 1 is that the total weight of raw materials remains the same when preparing the medical antibacterial nursing gel, but the amount of each component is different. The differences are shown in Table 1.

[0055] Table 1 shows the differences between Examples 2-5 and Example 1. (See Table 1 for details.)

[0056]

[0057]

[0058] Comparative Examples 1-3

[0059] Comparative Example 1

[0060] The difference between this comparative example and Example 3 is that the Chinese herbal medicine used in this comparative example is 12 kg of calendula.

[0061] Comparative Example 2

[0062] The difference between this comparative example and Example 3 is that the Chinese herbal medicine used in this comparative example is 12 kg of Centella asiatica.

[0063] Comparative Example 3

[0064] The difference between this comparative example and Example 3 is that the Chinese herbal medicine used in this comparative example is 12 kg of Sophora flavescens.

[0065] Experimental testing

[0066] 1. Stability test: The medical antibacterial care gels of Examples 1 to 18 and Comparative Examples 1 to 3 were placed in a constant temperature incubator at 37℃ to 40℃ for 3 months, with a relative humidity of 75% to 85%. Samples were taken at 0 and 3 months to examine the pH value of the medical antibacterial care gels and compared with the test results at 0 months to determine the storage stability of the medical antibacterial care gels.

[0067] 2. Antibacterial rate test: The medical antibacterial nursing gels of Examples 1-18 and Comparative Examples 1-3 were used for sterilization experiments. According to the test methods in the "Disinfection Technical Specifications", Escherichia coli and Staphylococcus aureus were used as test species for the experiment.

[0068] 3. Skin irritation test: Take the medical antibacterial care gels of Examples 1-18 and Comparative Examples 1-3 and conduct skin irritation tests in accordance with Article 2.3.3 of the 2002 edition of the "Disinfection Technical Specifications".

[0069] The test results are shown in Table 2.

[0070] Table 2 shows the experimental results of Examples 1-5 and Comparative Examples 1-3.

[0071]

[0072]

[0073] Results Analysis

[0074] As can be seen from Examples 1-5, Comparative Examples 1-3 and Table 2, the medical antibacterial nursing gel prepared according to the raw materials and proportions of this application has a good antibacterial effect against Escherichia coli and Staphylococcus aureus. At the same time, the use of Calendula officinalis, Centella asiatica and Sophora flavescens can significantly enhance the antibacterial properties of the medical antibacterial nursing gel. The prepared medical antibacterial nursing gel has good stability and is mild and non-irritating.

[0075] Examples 6-7

[0076] Example 6

[0077] The difference between Example 6 and Example 3 is that the total weight of the Chinese herbal medicines is 12kg, and the weight ratio of Calendula officinalis, Centella asiatica and Sophora flavescens is 6:5:4.

[0078] Example 7

[0079] The difference between Example 7 and Example 3 is that the total weight of the Chinese herbal medicines is 12kg, and the weight ratio of Calendula officinalis, Centella asiatica and Sophora flavescens is 7:6:4.8.

[0080] The test results are shown in Table 3.

[0081] Table 3 shows the experimental results of Examples 6 and 7.

[0082]

[0083]

[0084] Results Analysis

[0085] As can be seen from Examples 3, 6-7 and Table 3, the combination of Calendula officinalis, Centella asiatica and Sophora flavescens enhances the overall antibacterial effect of the medical antibacterial care gel. When the weight ratio of the three is (5-7):(4-6):(3-4.8), the antibacterial effect of the medical antibacterial care gel is better.

[0086] Examples 8-10

[0087] Example 8

[0088] The difference between Example 8 and Example 6 is that the total weight of chlorhexidine gluconate and traditional Chinese medicine is 15 kg, and the weight ratio of chlorhexidine gluconate to traditional Chinese medicine is 1:2.9.

[0089] Example 9

[0090] The difference between Example 9 and Example 6 is that the total weight of chlorhexidine gluconate and traditional Chinese medicine is 15 kg, and the weight ratio of chlorhexidine gluconate to traditional Chinese medicine is 1:3.6.

[0091] Example 10

[0092] The difference between Example 10 and Example 6 is that the total weight of chlorhexidine gluconate and traditional Chinese medicine is 15 kg, and the weight ratio of chlorhexidine gluconate to traditional Chinese medicine is 1:4.2.

[0093] The test results are shown in Table 4.

[0094] The experimental results of Examples 8-10 in Table 4 are shown in Table 4.

[0095]

[0096] Results Analysis

[0097] Based on Examples 6, 8-10 and Table 4, it can be seen that when the weight ratio of chlorhexidine gluconate to traditional Chinese medicine is 1:(2.9-4.2), the medical antibacterial nursing gel is stable, mild, and non-irritating, and has a better antibacterial effect.

[0098] Examples 11-13

[0099] Example 11

[0100] The difference between Example 11 and Example 9 is that the amount of carbomer remains the same, and the weight ratio of carbomer to triethanolamine is 1:1.

[0101] Example 12

[0102] The difference between Example 12 and Example 9 is that the amount of carbomer remains the same, and the weight ratio of carbomer to triethanolamine is 1:1.35.

[0103] Example 13

[0104] The difference between Example 13 and Example 9 is that the amount of carbomer remains the same, and the weight ratio of carbomer to triethanolamine is 1:2.

[0105] The test results are shown in Table 5.

[0106] Table 5 shows the experimental results of Examples 11-13.

[0107]

[0108] Results Analysis

[0109] As can be seen from Examples 9, 11-13 and Table 5, when the mass ratio of carbomer to triethanolamine is 1:(1-2), the medical antibacterial nursing gel is stable, mild and non-irritating, and has a better antibacterial effect.

[0110] Examples 14-16

[0111] Example 14

[0112] The difference between Example 14 and Example 12 is that the pH is adjusted to 6.2 in step S3.

[0113] Example 15

[0114] The difference between Example 15 and Example 12 is that the pH is adjusted to 7 in step S3.

[0115] Example 16

[0116] The difference between Example 16 and Example 12 is that the pH is adjusted to 7.5 in step S3.

[0117] The test results are shown in Table 6.

[0118] Table 6 shows the experimental results of Examples 14-16.

[0119]

[0120] Results Analysis

[0121] Based on Examples 12, 14-16 and Table 6, it can be seen that when the pH of the gel is 6.7-7, the medical antibacterial nursing gel is stable, mild and non-irritating, and has a better antibacterial effect.

[0122] Preparation of modified nano-silver: Add an equal volume of 4 g / L sodium hydroxide solution to a 0.6 g / L dopamine hydrochloride solution and mix and stir. Then add an equal volume of 2 g / L silver nitrate solution to the dopamine hydrochloride solution and stir thoroughly. After centrifuging the solution, a precipitate is obtained. The precipitate is washed and dried to obtain modified nano-silver.

[0123] Example 17

[0124] The difference between Example 17 and Example 12 is that 0.06 kg of modified nano-silver was added.

[0125] Example 18

[0126] The difference between Example 18 and Example 12 is that 0.06 kg of nano silver was added.

[0127] The test results are shown in Table 7.

[0128] Table 7 shows the experimental results of Examples 17-18.

[0129]

[0130]

[0131] Results Analysis

[0132] As can be seen from Examples 12, 17-18 and Table 7, adding nano-silver can enhance the antibacterial ability of the medical antibacterial care gel. Adding modified nano-silver can further enhance the antibacterial ability of the medical antibacterial care gel, resulting in a medical antibacterial care gel with better antibacterial performance.

[0133] The medical antibacterial nursing gels from Examples 1 to 18 were subjected to acute oral toxicity tests, acute inhalation toxicity tests, and mutagenicity tests according to the testing methods in the "Disinfection Technical Specifications".

[0134] Test results: The medical antibacterial nursing gels in Examples 1-18 are practically non-toxic when taken orally or inhaled acutely, and have no mutagenicity.

[0135] In summary, the medical antibacterial nursing gel prepared from the raw materials and formulations of this application has good antibacterial effect, excellent stability, and is mild, non-toxic, and non-irritating.

[0136] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A medical antibacterial nursing gel, characterized in that, Based on 100 parts by weight, the following raw materials are included: 1-5 parts chlorhexidine gluconate, 4-20 parts traditional Chinese medicine, 50-70 parts ethanol, 2-8 parts glycerol, 0.01-0.1 parts hydrogenated polyisobutylene, 0.15-0.5 parts carbomer, 0.2-0.7 parts triethanolamine, and the balance being deionized water. The Chinese herbal medicines mentioned are calendula, centella asiatica and sophora flavescens in a weight ratio of (5-7):(4-6):(3-4.8); The preparation method of the medical antibacterial nursing gel includes the following steps: extracting Chinese herbal medicines with ethanol and filtering them to obtain a Chinese herbal medicine extract.

2. The medical antibacterial nursing gel according to claim 1, characterized in that, Based on 100 parts by weight, the following raw materials are included: 2-4 parts chlorhexidine gluconate, 8-16 parts traditional Chinese medicine, 56-67 parts ethanol, 4-6 parts glycerol, 0.03-0.07 parts hydrogenated polyisobutylene, 0.25-0.35 parts carbomer, 0.3-0.5 parts triethanolamine, and the balance being deionized water.

3. The medical antibacterial nursing gel according to claim 1, characterized in that, The weight ratio of chlorhexidine gluconate to traditional Chinese medicine is 1:(2.9-4.2).

4. The medical antibacterial nursing gel according to claim 1, characterized in that, The weight ratio of carbomer to triethanolamine is 1:(1-2).

5. The medical antibacterial nursing gel according to claim 1, characterized in that, The raw materials of the medical antibacterial nursing gel also include 0.04-0.07 parts by weight of modified nano-silver; The preparation steps of the modified nano-silver include: adding an equal volume of 3-5 g / L sodium hydroxide solution to a 0.5-0.7 g / L dopamine hydrochloride solution and mixing and stirring, then adding an equal volume of 1-3 g / L silver nitrate solution to the dopamine hydrochloride solution and stirring thoroughly, centrifuging the solution to obtain a precipitate, washing and drying the precipitate to obtain modified nano-silver.

6. The medical antibacterial nursing gel according to claim 5, characterized in that, The modified silver nanoparticles have a particle size of 10-20 nm.

7. A method for preparing a medical antibacterial nursing gel according to any one of claims 1-6, characterized in that, Includes the following steps: S1. After mixing the herbal extract and glycerin, add the other ingredients except carbomer and triethanolamine, mix well, and disperse using ultrasound to obtain mixture I. S2. Add carbomer to mixture I and stir. Let stand overnight to obtain a colloid. S3. Add triethanolamine to the colloid and stir, adjust the pH to obtain the medical antibacterial care gel.

8. The method for preparing the medical antibacterial nursing gel according to claim 7, characterized in that, In step S3, adjust the pH to 6.7-7.

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