Whitening botanical compositions, methods of making and using the same

Abstract

The present application relates to the technical field of cosmetics, in particular to a whitening plant composition, a preparation method and application thereof. The whitening plant composition comprises a whitening agent and a cactus extract compound in a mass ratio of (20-40):1; the cactus extract compound comprises a cactus extract aggregate and cerium oxide particles doped with each other; the cactus extract compound is prepared from cerium oxide and cactus extract in a mass ratio of 1:(1-50). The whitening plant composition can improve the oxidation discoloration problem in cosmetic formulations, especially the oxidation discoloration problem in whitening cosmetic formulations.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a whitening plant composition, its preparation method, and its application. Background Technology

[0002] Oxidation and discoloration of whitening cosmetics is a common and unresolved problem in cosmetic formulations. Commonly used ingredients, such as tranexamic acid, 4-butylresorcinol, arbutin, vitamin C, tocopherol, and carnosine, are all susceptible to this issue. While the dehydrogenation of vitamin C to dehydroascorbic acid in the presence of enzymes and metal ions is reversible, the further oxidation of dehydroascorbic acid to 2,3-diketogulonic acid (yellow-brown) is irreversible. Components containing phenolic hydroxyl groups, such as 4-butylresorcinol, are oxidized to quinones, which are themselves colored (yellow) compounds.

[0003] Currently, the solution to the problem of oxidation and discoloration in whitening cosmetics is to add antioxidants. However, apart from a few raw materials such as fullerenes, which have electron-transferring capabilities, most antioxidant ingredients sacrifice themselves to achieve their antioxidant effect. Sodium metabisulfite, a commonly used antioxidant in cosmetics, can prevent discoloration, but because it prevents discoloration by sulfonating double bonds and disrupting the conjugated system, discoloration will still occur once the sodium metabisulfite is depleted. Therefore, it is necessary to find a plant-based composition with sustainable antioxidant properties to solve the problem of oxidation and discoloration in cosmetic formulations.

[0004] In view of this, the present invention is hereby proposed. Summary of the Invention

[0005] One object of the present invention is to provide a whitening plant composition to solve the technical problems existing in the prior art, such as the easy oxidation and discoloration of whitening plant compositions.

[0006] Another object of the present invention is to provide a method for preparing a whitening plant composition.

[0007] Another object of the present invention is to provide the application of whitening plant compositions in the preparation of whitening cosmetics.

[0008] In order to achieve the above-mentioned objectives of the present invention, one aspect of the present invention provides a whitening plant composition comprising a whitening agent and a cactus extract complex in a mass ratio of (20-40):1;

[0009] The cactus extract complex comprises aggregates of cactus extract and cerium oxide particles doped with the aggregates.

[0010] The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(1-50).

[0011] In a specific embodiment of the present invention, the cactus extract complex is mainly prepared by the cactus extract in a mass ratio of 1:(1-20).

[0012] The present invention also provides a method for preparing any one of the above-described whitening plant compositions, comprising the following steps:

[0013] (a) Cerium oxide and cactus extract were co-precipitated, and the precipitate was collected; the precipitate was dissolved in water and freeze-dried to obtain freeze-dried powder;

[0014] (b) Mix the freeze-dried powder with the whitening agent in a certain proportion.

[0015] In a specific embodiment of the present invention, a cerium oxide dispersion is added to a solution of cactus extract to perform the coprecipitation.

[0016] In a specific embodiment of the present invention, the cerium oxide dispersion comprises cerium oxide and a solvent; the solvent comprises at least one of ethanol, methanol and acetone.

[0017] In a specific embodiment of the present invention, the mass ratio of cerium oxide to solvent in the cerium oxide dispersion is 1:(1-500).

[0018] In a specific embodiment of the present invention, the solid content in the cactus extract solution is 3% to 5%.

[0019] In a specific embodiment of the present invention, in step (a), the mass ratio of the precipitate to the water is 1:(8-12).

[0020] In a specific embodiment of the present invention, the preparation of the cactus extract solution includes:

[0021] (1) The cactus was extracted with water. After the extraction was completed, the cactus was allowed to stand and age, and the supernatant was collected.

[0022] (2) Neutral protease and α-amylase were added to the supernatant for enzymatic extraction. After extraction, the enzymes were inactivated by heating.

[0023] (3) The enzyme-inactivated solution is decolorized and filtered, and then concentrated to obtain the cactus extract solution.

[0024] In a specific embodiment of the present invention, in step (1), the mass ratio of the water to the cactus is (20-50):1.

[0025] In a specific embodiment of the present invention, the amount of neutral protease used is 0.05% to 0.5% of the mass of the cactus in step (1); the amount of α-amylase used is 0.05% to 0.5% of the mass of the supernatant.

[0026] In a specific embodiment of the present invention, step (2) includes: extracting at 40-80°C for 0.5-3 hours, and then heating to 50-85°C for 0.5-3 hours.

[0027] In another aspect, the present invention also provides the application of any of the above-described whitening plant compositions in the preparation of cosmetics.

[0028] The present invention also provides a lotion with whitening effect, comprising any one of the whitening plant compositions described above.

[0029] In a specific embodiment of the present invention, the emulsion comprises the following components in parts by weight:

[0030] The mixture contains 60-80 parts solvent, 0.1-10 parts whitening plant composition, 5-15 parts moisturizer, 5-20 parts skin moisturizer, 0.5-5 parts emulsifier, 0.1-5 parts co-emulsifier, 0.05-1 part thickener, and 0.01-1 part chelating agent. Further, it also includes 0.1-5 parts preservative.

[0031] In a specific embodiment of the present invention, the moisturizer includes butylene glycol and / or glycerin.

[0032] In a specific embodiment of the present invention, the emollient includes polydimethylsiloxane and / or caprylic / capric triglyceride.

[0033] In a specific embodiment of the present invention, the emulsifier includes at least one of sucrose stearate, cetearyl glucoside, and cetyl alcohol.

[0034] In a specific embodiment of the present invention, the co-emulsifier includes glyceryl stearate.

[0035] In a specific embodiment of the present invention, the thickener includes acrylate / C10-30 alkanol acrylate crosspolymers and / or xanthan gum.

[0036] In a specific embodiment of the present invention, the chelating agent includes disodium EDTA.

[0037] In a specific embodiment of the present invention, the preservative includes phenoxyethanol and / or ethylhexylglycerin.

[0038] In a specific embodiment of the present invention, the preparation method of the emulsion with whitening effect includes the following steps:

[0039] (1) Mix the humectant, thickener and chelating agent in a solvent and heat to 80-85°C, then keep warm.

[0040] (2) Mix the emollient, emulsifier and co-emulsifier and heat to 80-85°C. Stir and melt into a liquid. Add the mixture to the material obtained in step (1) to obtain a mixture.

[0041] (3) Homogenize the mixture until it is uniformly emulsified, defoam and cool it down; when it is cooled to 60-65°C, homogenize it until it is uniform; then cool it down to below 45°C, add the whitening plant composition and stir to obtain the plant moisturizing emulsion.

[0042] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0043] (1) The whitening plant composition of the present invention can improve the problem of oxidative discoloration in cosmetic formulations, especially the problem of oxidative discoloration in whitening cosmetic formulations;

[0044] (2) In the whitening emulsion of the present invention, after adding the whitening plant composition of the present invention, the problem of color change of cosmetic formula can be solved while ensuring the whitening effect and system stability. Attached Figure Description

[0045] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0046] Figure 1 SEM images of the whitening plant composition of Example 1 (left) and the whitening plant composition of Comparative Example 2 (right);

[0047] Figure 2 Photographs showing the system stability of the whitening emulsions provided for embodiments and comparative examples of the present invention;

[0048] Figure 3 The skin feel evaluation results of the whitening lotion provided in the embodiments and comparative examples of the present invention;

[0049] Figure 4 This is a photograph of the color change of the whitening lotion of Example 6 of the present invention.

[0050] Figure 5 These are actual photos comparing the color changes of the whitening lotions from Example 6 (left) and Example 10 (right) of the present invention.

[0051] Figure 6 The image shows the color change of the whitening lotion in Comparative Example 7.

[0052] Figure 7 The images show a comparison of the color changes of the whitening lotions of Example 6 (left) and Comparative Example 12 (right) of this invention. Detailed Implementation

[0053] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings and specific embodiments. However, those skilled in the art will understand that the embodiments described below are some embodiments of the present invention, but not all embodiments, and are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall be followed. Where the manufacturers of reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0054] The present invention provides a whitening plant composition comprising a whitening agent and a cactus extract complex in a mass ratio of (20-40):1;

[0055] The cactus extract complex comprises aggregates of cactus extract and cerium oxide particles inter-doped within the aggregates.

[0056] The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(1-50).

[0057] In the whitening plant composition of the present invention, cactus extract encapsulates cerium oxide particles to form co-doped aggregates, which are then compounded with whitening agents to prevent the whitening agents from oxidizing and discoloring in the formulation.

[0058] In different embodiments, the mass ratio of cerium oxide to cactus extract in preparing the cactus extract complex can be 1:1, 1:5, 1:10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, or any combination thereof.

[0059] In different embodiments, the mass ratio of the whitening agent to the cactus extract complex can be 20:1, 25:1, 30:1, 35:1, 40:1, or any combination thereof.

[0060] In the preparation of the cactus extract complex, the calculation of the mass ratio of cerium oxide to cactus extract is based on the solid content of cerium oxide and cactus extract, respectively.

[0061] The whitening agent of this invention is an organic whitening agent, whose structure includes a reducing group and, after oxidation, possesses a chromophore group. The chromophore group refers to a group that causes the oxidized substance to absorb light in the ultraviolet and visible light regions, particularly a group that absorbs light in the visible light region. Whitening agents that meet the above conditions will exhibit visible color change after oxidation.

[0062] In a specific embodiment of the present invention, the cactus extract complex is mainly prepared by cerium oxide and cactus extract in a mass ratio of 1:(1-20).

[0063] In the cactus extract complex, cerium oxide particles may be partially doped on the surface of the aggregates. In the complex, cerium oxide particles are mainly doped inside the aggregates of cactus extract, such as ≥80%, ≥85%, ≥90%, or ≥95% of cerium oxide particles are doped inside the aggregates of cactus extract.

[0064] This invention also provides a method for preparing any of the above-mentioned whitening plant compositions, comprising the following steps:

[0065] (a) Cerium oxide and cactus extract were co-precipitated, and the precipitate was collected; the precipitate was dissolved in water and freeze-dried to obtain freeze-dried powder;

[0066] (b) Mix the freeze-dried powder with the whitening agent in a certain proportion.

[0067] In practice, in step (b), the lyophilized powder and the whitening agent can be mixed by mechanical grinding or by stirring. The mixing time can be 5 to 20 minutes, but is not limited to this.

[0068] In a specific embodiment of the present invention, a cerium oxide dispersion is added to a solution of cactus extract for co-precipitation.

[0069] In a specific embodiment of the present invention, the cerium oxide dispersion comprises cerium oxide and a solvent; the solvent comprises at least one selected from ethanol, methanol, and acetone. The cerium oxide dispersion is obtained by uniformly dispersing cerium oxide particles in the corresponding solvent.

[0070] In a specific embodiment of the present invention, the mass ratio of cerium oxide to solvent in the cerium oxide dispersion is 1:(1-500).

[0071] In different embodiments, the mass ratio of cerium oxide to solvent in the cerium oxide dispersion can be 1:1, 1:10, 1:50, 1:80, 1:100, 1:150, 1:200, 1:250, 1:300, 1:350, 1:400, 1:450, 1:500, or any combination thereof.

[0072] In a specific embodiment of the present invention, the solid content in the cactus extract solution is 3% to 5%.

[0073] In different embodiments, the solid content in the cactus extract solution can be a range of 3%, 3.5%, 4%, 4.5%, 5%, or any combination thereof.

[0074] In a specific embodiment of the present invention, the temperature of the cactus extract solution is 40–80°C; the temperature of the cerium oxide dispersion is 40–80°C.

[0075] In different embodiments, the cactus extract solution and cerium oxide dispersion can be preheated to 40°C, 45°C, 50°C, 55°C, 60°C, 65°C, 70°C, 75°C, 80°C, etc., before a mixed co-precipitation reaction is carried out.

[0076] In practice, the cactus extract solution is ultrasonically treated during the addition of the cerium oxide dispersion to ensure uniform mixing. The cerium oxide dispersion is preferably added dropwise.

[0077] In a specific embodiment of the present invention, in step (a), the mass ratio of precipitate to water is 1:(8-12).

[0078] In different embodiments, the mass ratio of precipitate to water can be 1:8, 1:9, 1:10, 1:11, 1:12, or any combination thereof.

[0079] In practice, freeze drying can be carried out in a conventional freeze dryer.

[0080] In a specific embodiment of the present invention, the preparation of the cactus extract solution includes:

[0081] (1) The cactus was extracted with water. After the extraction was completed, the cactus was allowed to stand and age, and the supernatant was collected.

[0082] (2) Add neutral protease and α-amylase to the supernatant for enzymatic extraction. After extraction, raise the temperature to inactivate the enzymes.

[0083] (3) The enzyme-inactivated solution was decolorized and filtered, and then concentrated to obtain a solution of cactus extract.

[0084] In a specific embodiment of the present invention, in step (1), the mass ratio of water to cactus is (20-50):1.

[0085] In different implementations, in step (1), the mass ratio of water to cactus can be 20:1, 25:1, 30:1, 35:1, 40:1, 45:1, 50:1, or any combination thereof.

[0086] In a specific embodiment of the present invention, step (1) includes: stirring and extracting at 40-80°C for 1-4 hours, and heating to 80-95°C and keeping warm for 10-40 minutes.

[0087] In different implementations, in step (1), the sample can be stirred and extracted at 40°C, 50°C, 60°C, 70°C or 80°C for 1h, 2h, 3h or 4h, and then heated to 80°C, 85°C, 90°C or 95°C and kept warm for 10min, 20min, 30min or 40min.

[0088] In a specific embodiment of the present invention, the settling and aging time is 12 to 18 hours.

[0089] In different embodiments, the settling and aging time can be 12h, 14h, 15h, 16h, 18h, or any combination thereof. Settling and aging removes starch components from the extract.

[0090] In a specific embodiment of the present invention, the amount of neutral protease used is 0.05% to 0.5% of the mass of the cactus in step (1); the amount of α-amylase used is 0.05% to 0.5% of the mass of the supernatant.

[0091] In different embodiments, the amount of neutral protease can be 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% of the mass of the plant material in step (1), or any combination thereof; the amount of α-amylase can be 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% of the mass of the supernatant, or any combination thereof.

[0092] In a specific embodiment of the present invention, step (2) includes: extracting at 40-80°C for 0.5-3 hours, and then heating to 50-85°C for 0.5-3 hours.

[0093] In different embodiments, step (2) of enzymatic extraction may include: first, stirring and extracting at 40℃, 50℃, 60℃, 70℃ or 80℃ for 0.5h, 1h, 2h or 3h, and then heating to 50℃, 60℃, 70℃, 80℃ or 85℃ for 0.5h, 1h, 2h or 3h. The extraction temperature after heating is higher than the previous extraction temperature.

[0094] In a specific embodiment of the present invention, the enzyme inactivation by heating includes: treating at 95-100°C for 30-40 minutes.

[0095] In a specific embodiment of the present invention, activated carbon is used for decolorization. Further, the decolorization includes: cooling the enzyme-inactivated solution to 65-70°C, adding 0.1wt%-10wt% activated carbon to the enzyme-inactivated solution, continuing to heat to 80-85°C and holding for 1-1.5 hours, and then cooling to 60-65°C.

[0096] In different embodiments, the amount of activated carbon used can be 0.1 wt%, 0.5 wt%, 1 wt%, 2 wt%, 5 wt%, 8 wt%, 10 wt%, or any combination thereof, of the enzyme-inactivated solution.

[0097] In a specific embodiment of the present invention, the filtration process includes: filtering the decolorized material through paperboard and / or diatomaceous earth. For example, 0.3-50μm paperboard and / or diatomaceous earth BS10# can be used for filtration.

[0098] In another aspect, the present invention also provides the application of any of the above-mentioned whitening plant compositions in the preparation of cosmetics.

[0099] The present invention also provides a lotion with whitening effect, comprising any of the above-mentioned whitening plant compositions.

[0100] In a specific embodiment of the present invention, the emulsion comprises the following components in parts by weight:

[0101] The mixture contains 60-80 parts solvent, 0.1-10 parts whitening plant composition, 5-15 parts moisturizer, 5-20 parts skin moisturizer, 0.5-5 parts emulsifier, 0.1-5 parts co-emulsifier, 0.05-1 part thickener, and 0.01-1 part chelating agent. Further, it also includes 0.1-5 parts preservative.

[0102] In different implementation methods, the amounts of each component in the emulsion, by weight, can be as follows:

[0103] The amount of solvent used can be 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, or any combination thereof;

[0104] The dosage of the whitening plant composition can be 0.1 parts, 0.5 parts, 1 part, 2 parts, 5 parts, 8 parts, 10 parts, or any combination thereof;

[0105] The amount of moisturizer used can be 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, or any combination thereof;

[0106] The amount of moisturizer used can be 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, or any combination thereof;

[0107] The amount of emulsifier can be 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, or any combination thereof;

[0108] The amount of co-emulsifier can be 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, or any combination thereof;

[0109] The amount of thickener can be 0.05 parts, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 part, or any combination thereof;

[0110] The amount of chelating agent can be 0.01 parts, 0.05 parts, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 part, or any combination thereof;

[0111] If preservatives are included, the amount of preservatives may be 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, or any combination thereof.

[0112] In a specific embodiment of the present invention, the moisturizer includes butylene glycol and / or glycerin.

[0113] In a specific embodiment of the present invention, the emollient includes polydimethylsiloxane and / or caprylic / capric triglyceride.

[0114] In a specific embodiment of the present invention, the emulsifier includes at least one of sucrose stearate, cetearyl glucoside, and cetyl alcohol.

[0115] In a specific embodiment of the present invention, the co-emulsifier includes glyceryl stearate.

[0116] In a specific embodiment of the present invention, the thickener includes acrylate / C10-30 alkanol acrylate crosspolymers and / or xanthan gum.

[0117] In a specific embodiment of the present invention, the chelating agent includes disodium EDTA.

[0118] In a specific embodiment of the present invention, the preservative includes phenoxyethanol and / or ethylhexylglycerin.

[0119] In a specific embodiment of the present invention, the method for preparing a whitening lotion includes the following steps:

[0120] (1) Mix the humectant, thickener and chelating agent in a solvent and heat to 80-85°C, then keep warm.

[0121] (2) Mix the emollient, emulsifier and co-emulsifier and heat to 80-85°C. Stir and melt into a liquid. Add the mixture to the material obtained in step (1) to obtain a mixture.

[0122] (3) Homogenize the mixture until it is uniformly emulsified, defoam and cool it down; when it is cooled to 60-65°C, homogenize it until it is uniform; then cool it down to below 45°C, add the whitening plant composition and stir to obtain the plant moisturizing emulsion.

[0123] If the emulsion contains preservatives, the preservatives can be mixed with the remaining materials in step (2).

[0124] Example 1

[0125] This embodiment provides a method for preparing a whitening plant composition, including the following steps:

[0126] (1) Take the stem of the Prunus persica and crush it, then pass it through a 60-mesh sieve. Then take the crushed Prunus persica stem powder, add purified water at a material-to-liquid ratio of 1:20 (m:m), heat to 50-55℃ and stir to extract for 2 hours, then heat to 82±2℃ and keep warm for 20 minutes, turn off the stirring and let it stand for 15 hours to age.

[0127] (2) Take the supernatant of the material after standing and aging in step (1) and weigh it. Add 0.2wt% of neutral protease based on the weight of the Prunus persica stem powder used in step (1) and 0.1wt% of α-amylase based on the weight of the supernatant. Then heat to 52±2℃ and stir to extract for 1h, and then heat to 82±2℃ and stir to extract for 1h.

[0128] (3) Heat the material extracted in step (2) to 95-100℃, heat and stir for 30 minutes to complete enzyme inactivation; then cool down to 70℃, start stirring, add activated carbon at 1wt% of the material mass, then heat to 82±2℃ and keep warm for 1 hour, then cool down to 62±2℃.

[0129] (4) Add the material processed in step (3) to diatomaceous earth BS10# filter to obtain coarse filtrate; then use conventional vacuum concentration operation to concentrate to a solid content of 5% to obtain a cactus extract solution.

[0130] (5) Weigh cerium oxide according to the mass ratio of cerium oxide to cactus extract obtained in step (4) (calculated based on the solid content of the solution obtained in step (4) being 5%), and then add anhydrous ethanol with a mass of 400 times that of cerium oxide to the cerium oxide and stir evenly to obtain cerium oxide ethanol dispersion.

[0131] (6) Heat the cactus extract solution from step (4) and the cerium oxide ethanol dispersion from step (5) to 60°C. Under ultrasonic conditions (ultrasonic power of 100W and ultrasonic temperature of 60°C), add the cerium oxide ethanol dispersion dropwise to the cactus extract solution at 60°C at a dropping rate of 2-3 drops / s. After the addition is complete, centrifuge at 5000rpm for 20min and collect the lower precipitate. Dissolve the precipitate in 10 times its weight of pure water and then perform conventional freeze-drying to obtain the cactus extract complex.

[0132] (7) Weigh tranexamic acid and cactus extract complex at a mass ratio of 30:1, mix and grind them in a mortar for 10 minutes at room temperature to obtain whitening plant composition.

[0133] Example 2

[0134] This embodiment refers to Embodiment 1, the only difference being that the amount of cerium oxide used in step (5) is different.

[0135] In step (5) of this embodiment, cerium oxide is weighed according to a mass ratio of cerium oxide to cactus extract (based on solid content in solution) obtained in step (4) of 1:1. Then, anhydrous ethanol with a mass of 400 times that of cerium oxide is added to the cerium oxide and stirred evenly to obtain cerium oxide ethanol dispersion.

[0136] Example 3

[0137] This embodiment refers to Embodiment 1, the only difference being that the amount of cerium oxide used in step (5) is different.

[0138] In step (5) of this embodiment, cerium oxide is weighed according to a mass ratio of cerium oxide to cactus extract (based on solid content in solution) obtained in step (4) of 1:50. Then, anhydrous ethanol with a mass of 400 times that of cerium oxide is added to the cerium oxide and stirred evenly to obtain cerium oxide ethanol dispersion.

[0139] Example 4

[0140] This embodiment refers to Embodiment 1, the only difference being that the amount of cerium oxide used in step (5) is different.

[0141] In step (5) of this embodiment, cerium oxide is weighed according to a mass ratio of cerium oxide to cactus extract (based on solid content in solution) obtained in step (4) of 1:20. Then, anhydrous ethanol with a mass of 400 times that of cerium oxide is added to the cerium oxide and stirred evenly to obtain cerium oxide ethanol dispersion.

[0142] Example 5

[0143] This embodiment refers to Embodiment 1, the only difference being that the cactus extract solution used is different.

[0144] This embodiment does not include steps (1) to (4). The cactus extract is directly weighed, water is added, and an aqueous solution of cactus extract with a mass fraction of 5 wt% is prepared before proceeding to subsequent steps (5) to (7).

[0145] The cactus extract used in this embodiment is QA20230205 from Xi'an An'ao Biotechnology Co., Ltd.

[0146] Examples 6-12

[0147] This embodiment provides a whitening emulsion and its preparation method. The raw material composition of the emulsion is shown in Table 1. The specific preparation method includes the following steps:

[0148] (1) Soak the humectant, thickener and chelating agent in a preparation pot containing solvent, heat to 80-85℃ until completely dissolved and homogenized, homogenize for 1-2 minutes, keep warm for 20-30 minutes to sterilize and defoam, and set aside.

[0149] (2) Mix the emollient, emulsifier, co-emulsifier and preservative and heat to 80-85°C. Stir until it melts into a uniform liquid and then pump it into the preparation pot of step (1).

[0150] (3) Turn on the homogenizer and homogenize for 3-5 minutes until the emulsion is completely homogeneous. After defoaming, cool down; cool down to 60°C, keep warm and stir for 20 minutes until homogeneous to obtain the liquid crystal structure.

[0151] (4) Cool down to below 45°C, add the whitening plant composition, homogenize weakly for 2 minutes, mix evenly, continue stirring and cool to room temperature.

[0152] Table 1. Raw material composition (parts by weight) of different whitening lotions

[0153]

[0154]

[0155] The moisturizers include butylene glycol and glycerin in a mass ratio of 2:5;

[0156] The emollients include caprylic / capric triglyceride and polydimethylsiloxane in a mass ratio of 8:2;

[0157] Emulsifier A comprises sucrose stearate, cetearyl glucoside and cetyl alcohol in a mass ratio of 1.45:1.55:0.5.

[0158] Emulsifier B comprises cetearyl glucoside and cetyl alcohol in a mass ratio of 1.55:0.5;

[0159] The preservatives include phenoxyethanol and ethylhexylglycerin in a mass ratio of 0.1:0.5.

[0160] Comparative Example 1

[0161] Comparative Example 1 provides a method for preparing cactus extract, including the following steps:

[0162] (1) Take the stem of the Prunus persica and crush it, then pass it through a 60-mesh sieve. Then take the crushed Prunus persica stem powder, add pure water at a material-to-liquid ratio of 1:20 (m:m), heat to 52±2℃ and stir to extract for 2 hours, then heat to 82±2℃ and keep warm for 20 minutes, turn off the stirring and let it stand for 15 hours to age.

[0163] (2) Take the supernatant of the material after standing and aging in step (1) and weigh it. Add 0.2wt% of neutral protease based on the weight of the Prunus persica stem powder used in step (1) and 0.1wt% of α-amylase based on the weight of the supernatant. Then heat to 52±2℃ and stir to extract for 1h, and then heat to 82±2℃ and stir to extract for 1h.

[0164] (3) Heat the material extracted in step (2) to 95-100℃, heat and stir for 30 minutes to complete enzyme inactivation; then cool down to 70℃, start stirring, add activated carbon at 1wt% of the material mass, then heat to 82±2℃ and keep warm for 1 hour, then cool down to 62±2℃.

[0165] (4) Add the material processed in step (3) to diatomaceous earth BS10# filter to obtain coarse filtrate; then use conventional vacuum concentration operation to concentrate to a solid content of 5% to obtain a cactus extract solution.

[0166] (5) Add 95% ethanol aqueous solution to the cactus extract solution in step (4) until the mass fraction of ethanol in the mixed system reaches 80%, and then centrifuge to collect the lower precipitate.

[0167] (6) Dissolve the precipitate obtained in step (5) in 10 times its weight of purified water, and then freeze-dry it to obtain cactus extract.

[0168] Comparative Example 2

[0169] Comparative Example 2 provides a method for preparing a whitening plant composition, comprising the following steps:

[0170] Tranexamic acid, cactus extract prepared in Comparative Example 1, and cerium oxide particles were weighed in a mass ratio of 3.3:0.1:0.01 and mixed and ground in a mortar for 10 minutes at room temperature to obtain a whitening plant composition.

[0171] Comparative Example 3

[0172] Comparative Example 3 provides a method for preparing a whitening plant composition, comprising the following steps:

[0173] Tranexamic acid and cactus extract prepared in Comparative Example 1 were weighed at a mass ratio of 3.3:0.1 and mixed and ground in a mortar for 10 minutes at room temperature to obtain a whitening plant composition.

[0174] Comparative Example 4

[0175] Comparative Example 4 provides a method for preparing a skin-whitening plant composition, comprising the following steps:

[0176] Tranexamic acid and cerium oxide particles were weighed at a mass ratio of 3.3:0.01 and mixed and ground in a mortar for 10 minutes at room temperature to obtain a whitening composition.

[0177] Comparative Example 5

[0178] Comparative Example 5 refers to Example 1, except that the amount of cerium oxide used in step (5) is different.

[0179] In step (5) of Comparative Example 5, cerium oxide was weighed at a mass ratio of 1:0.5 to the cactus extract (based on the solid content in the solution) obtained in step (4). Then, anhydrous ethanol with a mass of 400 times that of cerium oxide was added to the cerium oxide and stirred evenly to obtain a cerium oxide ethanol dispersion.

[0180] When cerium oxide and cactus extract are combined in the ratio of Comparative Example 5, excessive cerium oxide will adhere to the surface of the cactus extract, hindering the film formation of the cactus extract.

[0181] Comparative Example 6

[0182] Comparative Example 6 refers to Example 1, except that the amount of cerium oxide used in step (5) is different.

[0183] In step (5) of Comparative Example 6, cerium oxide was weighed according to a mass ratio of cerium oxide to cactus extract (based on solid content in solution) obtained in step (4) of 1:60. Then, anhydrous ethanol with a mass of 400 times that of cerium oxide was added to the cerium oxide and stirred evenly to obtain a cerium oxide ethanol dispersion.

[0184] The cerium oxide and cactus extract were compounded in the ratio of Comparative Example 6. The cerium oxide content was too low to achieve the effect of preventing oxidation and discoloration.

[0185] Comparative Examples 7–20

[0186] Comparative Examples 7-20 provide an emulsion and its preparation method, wherein the raw material composition of the emulsion is shown in Table 2, and the specific preparation method is described in Example 6.

[0187] Table 2 Raw material composition (parts by weight) of different emulsions

[0188]

[0189]

[0190]

[0191] Unless otherwise specified, the components of the emulsion are as follows:

[0192] The moisturizers include butylene glycol and glycerin in a mass ratio of 2:5;

[0193] The emollients include caprylic / capric triglyceride and polydimethylsiloxane in a mass ratio of 8:2;

[0194] Emulsifier A comprises sucrose stearate, cetearyl glucoside and cetyl alcohol in a mass ratio of 1.45:1.55:0.5.

[0195] Emulsifier C comprises sucrose stearate, cetearyl glucoside, and cetyl alcohol in a mass ratio of 1:1:1;

[0196] The preservatives include phenoxyethanol and ethylhexylglycerin in a mass ratio of 0.1:0.5.

[0197] Experimental Example 1

[0198] Figure 1 The images show SEM images of the whitening plant composition of Example 1 and the whitening plant composition prepared in Comparative Example 2. As can be seen from the images, in the whitening plant composition prepared by the method of Comparative Example 2, cerium oxide particles are distributed on the outer surface of the cactus extract aggregates and are scattered on its surface; while in the whitening plant composition prepared by the method of Example 1 of this invention, cerium oxide particles can be well aggregated inside the cactus extract aggregates, resulting in a stable co-doped whitening plant composition.

[0199] Experimental Example 2

[0200] The stability of the emulsions prepared in different examples and comparative examples was observed. The prepared emulsions were placed at room temperature to observe whether there were obvious differences in properties. It was found that the emulsion of comparative example 15 had poor adhesion, the emulsion of comparative example 16 had precipitation, the oil and water separation phenomenon was observed in comparative examples 18 and 19, and the skin feel of comparative example 20 was poor.

[0201] The photographs of the emulsions prepared in Comparative Example 18 (left), Comparative Example 19 (middle), and Example 6 (right) are shown below. Figure 2 .

[0202] The skin feel evaluation results of the emulsions in Examples 6, 11, 12 and Comparative Example 20 are shown below. Figure 3 The skin feel evaluation method included: selecting 6 volunteers, applying products from Example 6, Example 11, Example 12, and Comparative Example 20 to the left and right sides of the subjects' faces respectively, and having the subjects subjectively evaluate the moisturizing, soft, refreshing, smooth, and sticky feeling using a 5-point scale (0 for no feeling, 1 for slight feeling, 2 for mild feeling, 3 for moderate feeling, and 4 for severe feeling). The experimental results are shown in […]. Figure 3 .

[0203] Microbial activity was tested in the emulsion systems prepared in different examples and comparative proportions. 1 mL of the original sample solution and a 10-fold dilution were respectively transferred into sterile petri dishes, with two dishes prepared for each dilution. Simultaneously, 1 mL of sterile physiological saline was added to a sterile petri dish as a blank control, with two parallel blanks prepared. Approximately 15 mL of lecithin Tween 80 nutrient agar medium, melted and cooled to 45–50°C, was poured into each petri dish. The dish was then rotated to ensure thorough mixing of the sample and medium. After the agar solidified, the dishes were inverted and incubated at 36°C ± 1°C for 48 h ± 2 h. To facilitate the differentiation between particles and colonies in the sample, 1 mL of 0.5% TTC solution was added to every 100 mL of lecithin Tween 80 nutrient agar. If bacteria were present, the colonies would turn red after incubation, while the sample particles would remain unchanged in color.

[0204] First, visually inspect and count the colonies, then examine them with a magnifying glass of 5x to 10x magnification to ensure no colonies are missed. Record the colony count for each plate and calculate the average colony count for each plate at the same dilution. If a plate contains clusters of colonies or speckled colonies spreading, that plate should not be counted. If clusters of colonies cover less than half the plate, but the remaining half has a uniform colony distribution, count the colonies in that half plate and multiply by 2 to represent the total colony count. The test results are shown in Table 3.

[0205] Table 3 Results of Total Colony Count Test

[0206] Example 6 ≤100 Example 7 ≤100 Example 11 ≤100 Example 12 ≤100 Comparative Example 7 ≤100 Comparative Example 8 ≤100 Comparative Example 11 ≤100 Comparative Example 17 Uncountable

[0207] Experimental Example 3

[0208] Different emulsion samples were kept at 55±1℃ for 14 days, and the color changes were observed after returning to room temperature compared with before the experiment.

[0209] Figures 4-7 The figures show the colors of the emulsions after testing in Examples 6, 10, 7, and 12 of this invention, respectively. As can be seen from the figures, Example 6 can effectively improve the discoloration problem of the whitening emulsion, indicating that the whitening plant composition used in this invention can effectively improve the discoloration phenomenon of whitening agents in cosmetic formulations.

[0210] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A whitening plant-based composition, characterized in that, It includes a whitening agent and a cactus extract complex in a mass ratio of (20-40):1; The cactus extract complex comprises aggregates of cactus extract and cerium oxide particles doped with the aggregates. The cactus extract complex is mainly prepared by cerium oxide and cactus extract in a mass ratio of 1:(1-50); The preparation of the cactus extract complex includes: preheating the cactus extract solution and the cerium oxide dispersion to 40-80°C respectively; then adding the cerium oxide dispersion to the cactus extract solution for co-precipitation and collecting the precipitate; dissolving the precipitate in water and freeze-drying it; and sonicating the cactus extract solution during the addition of the cerium oxide dispersion. The cerium oxide dispersion comprises cerium oxide and a solvent; the solvent comprises at least one selected from ethanol, methanol, and acetone. The preparation of the cactus extract solution includes: (1) Water was used to extract the cactus. After extraction, the cactus was allowed to stand and age, and the supernatant was collected. (2) Neutral protease and α-amylase were added to the supernatant for enzymatic extraction. After extraction, the enzymes were inactivated by heating. (3) The enzyme-inactivated solution is decolorized and filtered, and then concentrated to obtain the cactus extract solution.

2. The whitening plant composition according to claim 1, characterized in that, The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(1-20).

3. The whitening plant composition according to claim 1, characterized in that, The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(5-15).

4. The whitening plant composition according to claim 1, characterized in that, In step (1), the mass ratio of the water to the cactus is (20-50):1; The amount of neutral protease used is 0.05% to 0.5% of the mass of the cactus in step (1); The amount of α-amylase used is 0.05% to 0.5% of the mass of the supernatant; In step (2), the enzymatic extraction includes: extracting at 40-80℃ for 0.5-3h, and then heating to 50-85℃ for 0.5-3h.

5. A method for preparing the whitening plant composition according to any one of claims 1 to 4, characterized in that, Includes the following steps: (a) Cerium oxide and cactus extract were co-precipitated, and the precipitate was collected; the precipitate was dissolved in water and freeze-dried to obtain freeze-dried powder; (b) Mix the freeze-dried powder with the whitening agent in a certain proportion; The cactus extract solution and the cerium oxide dispersion were preheated to 40-80°C, respectively. Then, the cerium oxide dispersion was added to the cactus extract solution for co-precipitation. During the addition of the cerium oxide dispersion, the cactus extract solution was subjected to ultrasonic treatment. The cerium oxide dispersion comprises cerium oxide and a solvent; the solvent comprises at least one of ethanol, methanol and acetone.

6. The method for preparing the whitening plant composition according to claim 5, characterized in that, In the cerium oxide dispersion, the mass ratio of cerium oxide to the solvent is 1:(1-500).

7. The method for preparing the whitening plant composition according to claim 5, characterized in that, In step (a), the mass ratio of the precipitate to the water is 1:(8-12).

8. The method for preparing the whitening plant composition according to claim 5, characterized in that, The solid content in the cactus extract solution is 3% to 5%.

9. The use of the whitening plant composition according to any one of claims 1 to 4 or the whitening plant composition prepared by the preparation method according to any one of claims 5 to 8 in the preparation of cosmetics.

10. A lotion with whitening effects, characterized in that, This includes the whitening plant composition according to any one of claims 1 to 4 or the whitening plant composition prepared by the preparation method according to any one of claims 5 to 8.

11. The whitening lotion according to claim 10, characterized in that, Includes the following components by weight: The ingredients include 60-80 parts solvent, 0.1-10 parts whitening plant composition, 5-15 parts moisturizer, 5-20 parts skin moisturizer, 0.5-5 parts emulsifier, 0.1-5 parts co-emulsifier, 0.05-1 part thickener, and 0.01-1 part chelating agent.

12. The whitening lotion according to claim 11, characterized in that, It also includes 0.1 to 5 parts of preservatives.

13. The whitening lotion according to claim 11, characterized in that, The moisturizers include butylene glycol and / or glycerin.

14. The whitening lotion according to claim 11, characterized in that, The emollients include polydimethylsiloxane and / or caprylic / capric triglyceride.

15. The whitening lotion according to claim 11, characterized in that, The emulsifier includes at least one of sucrose stearate, cetearyl glucoside, and cetyl alcohol.

16. The whitening lotion according to claim 11, characterized in that, The co-emulsifier includes glyceryl stearate.

17. The whitening lotion according to claim 11, characterized in that, The thickener includes acrylate / C10-30 alkanol acrylate crosspolymers and / or xanthan gum.

18. The whitening lotion according to claim 11, characterized in that, The chelating agent includes disodium EDTA.

19. The whitening lotion according to claim 12, characterized in that, The preservatives include phenoxyethanol and / or ethylhexylglycerin.

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