Antibacterial medical silicone gel and preparation method thereof, medical tape and preparation method thereof

Abstract

This application relates to the technical field of medical materials, and in particular to an antibacterial medical silicone gel and its preparation method, a medical tape and its preparation method. The antibacterial medical silicone gel comprises the following raw materials in parts by weight: 90 - 95 parts of vinyl silicone oil, 3 - 8 parts of hydrogen-containing silicone oil, 0.5 - 5 parts of tackifier, 1 - 3 parts of antibacterial agent, and 0.5 - 3 parts of metal catalyst; the antibacterial agent is composed of activated carbon-coated silver nanoparticles and carboxymethyl chitosan. In this application, the activated carbon-coated silver nanoparticles and carboxymethyl chitosan are compounded to form a composite antibacterial agent, so that the composite antibacterial agent has the advantages of both organic antibacterial agents and inorganic antibacterial agents. The two produce a synergistic effect, enhancing the antibacterial effect, and adding it to the silicone gel can improve the antibacterial property of the silicone gel.

Description

Technical Field

[0001] The present application relates to the technical field of medical materials, and particularly relates to an antibacterial medical silicone gel and a preparation method thereof, a medical tape and a preparation method thereof. Background Art

[0002] Due to its unique Si-O-Si structure, silicone gel has a unique "breathability", is closer to the normal metabolism of human skin, enables faster wound healing, and at the same time has good stretchability, will not cause cracking and breaking, and has significant advantages. By appropriately controlling the crosslinking degree of the material during the preparation of the silicone gel material, a silicone gel material with a certain viscosity on the surface can be obtained, and the silicone gel material with surface viscosity can be made into a medical tape. However, due to its hydrophobicity, its ability to absorb and stop bleeding is poor, and its antibacterial and anti-infection properties are poor, which greatly limits its application in medical tapes.

[0003] Therefore, developing an antibacterial silicone gel has great practical significance for the development and use of medical tapes. Summary of the Invention

[0004] In order to improve the antibacterial property of silicone gel, the present application provides an antibacterial medical silicone gel and a preparation method thereof, a medical tape and a preparation method thereof.

[0005] In the first aspect, the present application provides an antibacterial medical silicone gel, adopting the following technical solution:

[0006] An antibacterial medical silicone gel, comprising the following raw materials in parts by weight: 90-95 parts of vinyl silicone oil, 3-8 parts of hydrogen-containing silicone oil, 0.5-5 parts of tackifier, 1-3 parts of antibacterial agent, and 0.5-3 parts of metal catalyst; the antibacterial agent is composed of activated carbon-coated silver nanoparticles and carboxymethyl chitosan.

[0007] By adopting the above technical solution, the activated carbon-coated silver nanoparticles are a core-shell structure with activated carbon as the shell and silver nanoparticles as the core, and the activated carbon shell is a porous structure, so that the silver particles can be released through the pores of the activated carbon shell to achieve the antibacterial effect; at the same time, the silver particles are coated in the activated carbon shell layer, which can prevent the silver particles from falling off quickly and can also prevent the silver particles from changing color under light, thereby ensuring the persistence of the antibacterial effect.

[0008] Chitosan has the function of promoting blood coagulation, can be used as a hemostatic agent, and can also be used as a wound filler substance, having the functions of sterilization and promoting wound healing; chitosan, as an organic antibacterial agent, has high biocompatibility, biotoxicity-free and biodegradability, and at the same time has a complex double helix structure, and the -OH and -NH in the structure 2They all have strong reactivity. After chemical modification with carboxymethyl groups, their solubility is improved, antibacterial activity is enhanced, and the antibacterial range is expanded.

[0009] In this application, a composite antibacterial agent is prepared by compounding activated carbon-coated silver nanoparticles with carboxymethyl chitosan, enabling the composite antibacterial agent to possess the advantages of both organic and inorganic antibacterial agents. The two exhibit a synergistic effect, enhancing the antibacterial effect. When added to silicone gel, it can improve the antibacterial property of the silicone gel.

[0010] In a specific feasible embodiment, the preparation method of the silver nanoparticles includes the following steps: Add 25 - 30 parts by weight of zirconium phosphate and 5 - 10 parts by weight of citric acid to 100 parts by weight of deionized water to prepare a suspension, then add 0.8 - 1.3 parts by weight of silver nitrate, stir for 12 - 24 h, filter, dry, calcine, and pulverize to obtain the silver nanoparticles.

[0011] By adopting the above technical solution, the silver nanoparticles are prepared by exchanging and loading silver particles on zirconium phosphate. They are fine powders with uniform particle size, having extremely low hygroscopicity and high heat resistance, stable physical and chemical properties, and good antibacterial effects.

[0012] In a specific feasible embodiment, the preparation method of the activated carbon is as follows: Take medical activated carbon, soak it in an acid solution, place it in a water bath at room temperature for oscillation, then wash it with water until the surface of the activated carbon is neutral, and then filter and dry to obtain the activated carbon.

[0013] By adopting the above technical solution, the activated carbon is acidified, its specific surface area and pore volume increase, so its adsorption property for silver nanoparticles is higher, and the release rate also increases relatively.

[0014] In a specific feasible embodiment, the preparation method of the carboxymethyl chitosan is as follows: Grind and mix chitosan, sodium alkoxide, and monochloroacetic acid with a mass ratio of 100:0.1 - 1:150 - 400, and react under heating and ultrasonic treatment conditions. After the reaction ends, separate to obtain the carboxymethyl chitosan.

[0015] By adopting the above technical solution, using sodium alkoxide as a catalyst to catalyze the de - HCl small molecule reaction between chitosan and monochloroacetic acid, carboxymethyl chitosan with a higher yield and higher degree of substitution can be obtained. This method avoids the large - scale use of organic solvents, and quickly evaporates the HCl small molecules generated in the system, ensuring that the reaction continuously moves forward to the positive direction, and can effectively improve the yield. This application uses a one - step solid - phase reaction method to carboxymethylate chitosan to obtain a high yield and high purity, thereby improving the synergistic antibacterial effect with activated carbon - coated nanoparticles.

[0016] In a specific feasible embodiment, the preparation method of the antibacterial agent includes the following steps:

[0017] Mix nano silver particles and activated carbon with a mass ratio of 85 - 95:5 - 15 to form a mixture, and subject the mixture to vacuum adsorption to obtain activated carbon-coated nano silver particles;

[0018] Add the activated carbon-coated nano silver particles to carboxymethyl chitosan, and after centrifugation and freeze-drying, the antibacterial agent is prepared.

[0019] By adopting the above technical solution, the vacuum adsorption method can make the nano silver particles evenly adsorbed in the microporous structure of the activated carbon; as a supporting carrier for the nano silver particles, the activated carbon not only has a porous structure, providing attachment points for the nano silver particles, but also has good antibacterial properties itself, making the formed activated carbon-coated nano silver particles have good antibacterial performance. Loading the activated carbon-coated nano silver particles on carboxymethyl chitosan, the prepared composite antibacterial agent has relatively long-lasting and excellent antibacterial properties.

[0020] In a specific feasible embodiment, the tackifier is a silane coupling agent.

[0021] By adopting the above technical solution, the tackifier can not only improve the viscosity of the silicone gel, but also effectively improve the bonding force between the silicone gel and the substrate. The corresponding silicone gel not only has good adhesion to the substrate, but also has good peel strength for the adhered object.

[0022] In a specific feasible embodiment, the metal in the metal catalyst includes one or more of ruthenium, rhodium, palladium, osmium, and platinum; preferably a platinum catalyst.

[0023] By adopting the above technical solution, the platinum catalyst can increase the speed and efficiency of chemical reactions, enable chemical reactions to be completed at a lower temperature, thereby reducing energy consumption and the generation of chemical waste, achieving the effect of energy conservation and emission reduction; at the same time, the platinum catalyst has high catalytic activity and stability, is not easily affected by the external environment, and can provide long-term reliable catalytic performance.

[0024] In the second aspect, the present application provides a preparation method of an antibacterial medical silicone gel, adopting the following technical solution:

[0025] A preparation method of an antibacterial medical silicone gel includes the following steps:

[0026] Mix a part of vinyl silicone oil with a metal catalyst to obtain glue A;

[0027] Mix hydrogen-containing silicone oil, a tackifier, and the remaining vinyl silicone oil to obtain glue B;

[0028] Mix glue A, glue B and an antibacterial agent to obtain the antibacterial silicone gel.

[0029] Thirdly, the present application provides a medical tape, adopting the following technical solution:

[0030] The medical tape includes the above-mentioned antibacterial medical silicone gel.

[0031] Fourthly, the present application provides a preparation method of a medical tape, adopting the following technical solution:

[0032] The preparation method of the medical tape is to coat the antibacterial silicone gel on a substrate.

[0033] By adopting the above technical solution, the antibacterial silicone gel prepared in the present application has better peel strength and antibacterial performance with the adherend, and at the same time, the corresponding material also has good adhesion, and there is no need to apply a primer solution on the substrate.

[0034] In summary, the present application includes at least one of the following beneficial technical effects:

[0035] 1. By adding a composite antibacterial agent composed of activated carbon-coated silver nanoparticles with a core-shell structure and carboxymethyl chitosan in the silicone gel, the composite antibacterial agent has the advantages of both organic antibacterial agents and inorganic antibacterial agents. The two produce a synergistic effect, enhancing the antibacterial effect and improving the antibacterial property of the silicone gel.

[0036] 2. By acidifying the activated carbon, its specific surface area and pore volume increase, so the adsorption of silver nanoparticles is higher, and the release rate also increases relatively.

[0037] 3. The silver nanoparticles in the present application are prepared by exchanging and loading silver particles on zirconium phosphate. It is a fine powder with uniform particle size, having extremely low hygroscopicity and very high heat resistance, with stable physical and chemical properties and good antibacterial effect. Specific Embodiments

[0038] The present application is further described in detail below through preparation examples, examples and comparative examples.

[0039] Preparation Examples

[0040] Preparation Example 1

[0041] This preparation example discloses an antibacterial agent, including the following steps:

[0042] (1) Preparation of silver nanoparticles: Add 28 g of zirconium phosphate and 7 g of citric acid to 100 g of deionized water to prepare a suspension, then add 1 g of silver nitrate, stir for 18 h, and then filter, dry, calcine and pulverize to obtain silver nanoparticles with a particle size of 5 nm; the calcination temperature is 800 °C and the time is 2.5 h.

[0043] (2) Preparation of activated carbon: Take 100 g of medical activated carbon, soak it in 300 ml of 0.1 mol / L HCl solution for 2 h, then place it in a water bath at room temperature and shake for 12 h. Rinse the activated carbon surface with distilled water until it is neutral, perform suction filtration, and dry it at 100 °C for 3 h to obtain the treated activated carbon;

[0044] (3) Preparation of activated carbon-coated silver nanoparticles: Mix 90 g of silver nanoparticles and 10 g of activated carbon evenly to form a mixture. Place the mixture in a vacuum drying oven for vacuum adsorption (the air pressure in the oven is -0.1 Mpa, the temperature is 70 °C, and the adsorption time is 15 h) to obtain activated carbon-coated silver nanoparticles;

[0045] (4) Preparation of carboxymethyl chitosan: Grind and premix 100 g of chitosan powder, 0.5 g of sodium propoxide solid, and 280 g of monochloroacetic acid evenly, and then place them in an ultrasonic system at 50 °C and a vacuum degree of -0.01 Mpa for reaction for 40 min; After the reaction, take out the reaction mixture and make it into a 10% aqueous solution with distilled water, filter out a small amount of water-soluble substances, and then dialyze the filtrate with a dialysis membrane to remove by-products such as sodium chloride, sodium chloroacetate, and chloroacetic acid generated during the reaction. The product after dialysis and impurity removal is carboxymethyl chitosan;

[0046] (5) Preparation of carboxymethyl chitosan-loaded activated carbon-coated silver nanoparticles: Add 10 g of activated carbon-coated silver nanoparticles to 40 g of carboxymethyl chitosan liquid, stir and mix, then perform centrifugation, and then freeze-dry to obtain the antibacterial agent.

[0047] Preparation Example 2

[0048] This preparation example discloses an antibacterial agent, which includes the following steps:

[0049] (1) Preparation of silver nanoparticles: Add 25 g of zirconium phosphate and 10 g of citric acid to 100 g of deionized water to prepare a suspension, then add 0.8 g of silver nitrate, stir for 12 h, and then perform filtration, drying, calcination, and pulverization to obtain silver nanoparticles with a particle size of 5 nm; The calcination temperature is 800 °C and the time is 2.5 h;

[0050] (2) Preparation of activated carbon: Take 100 g of medical activated carbon, soak it in 300 ml of 0.1 mol / L HCl solution for 2 h, then place it in a water bath at room temperature and shake for 12 h. Rinse the activated carbon surface with distilled water until it is neutral, perform suction filtration, and dry it at 100 °C for 3 h to obtain the activated carbon;

[0051] (3) Preparation of activated carbon-coated silver nanoparticles: Mix 85 g of silver nanoparticles and 15 g of activated carbon evenly to form a mixture. Place the mixture in a vacuum drying oven for vacuum adsorption (the air pressure in the oven is -0.1 Mpa, the temperature is 70 °C, and the adsorption time is 15 h) to obtain activated carbon-coated silver nanoparticles;

[0052] (4) Preparation of carboxymethyl chitosan: Grind and premix 100 g of chitosan powder, 0.1 g of sodium propoxide solid, and 150 g of monochloroacetic acid evenly, and then react in an ultrasonic system at 50 °C and a vacuum degree of -0.01 Mpa for 40 min; After the reaction, take out the reaction mixture and prepare it into a 10% aqueous solution with distilled water. Filter out a small amount of water-soluble substances, and then dialyze the filtrate with a dialysis membrane to remove by-products such as sodium chloride, sodium chloroacetate, and chloroacetic acid generated during the reaction. The product after dialysis and impurity removal is carboxymethyl chitosan;

[0053] (5) Preparation of carboxymethyl chitosan-loaded activated carbon-coated silver nanoparticles: Add 10 g of activated carbon-coated silver nanoparticles to 40 g of carboxymethyl chitosan liquid, stir and mix, then centrifuge, and then freeze-dry to obtain the antibacterial agent.

[0054] Preparation Example 3

[0055] This preparation example discloses an antibacterial agent, which includes the following steps:

[0056] (1) Preparation of silver nanoparticles: Add 30 g of zirconium phosphate and 5 g of citric acid to 100 g of deionized water to prepare a suspension, and then add 1.3 g of silver nitrate. After stirring for 24 h, filter, dry, calcine, and crush to obtain silver nanoparticles with a particle size of 5 nm; The calcination temperature is 800 °C and the time is 2.5 h;

[0057] (2) Preparation of activated carbon: Take 100 g of medical activated carbon, soak it in 300 ml of 0.1 mol / L HCl solution for 2 h, then place it in a water bath at room temperature and shake for 12 h, rinse the activated carbon surface with distilled water until it is neutral, filter by suction, and dry at 100 °C for 3 h to obtain activated carbon;

[0058] (3) Preparation of activated carbon-coated silver nanoparticles: Mix 95 g of silver nanoparticles and 5 g of activated carbon evenly to form a mixture. Place the mixture in a vacuum drying oven for vacuum adsorption (the air pressure in the oven is -0.1 Mpa, the temperature is 70 °C, and the adsorption time is 15 h) to obtain activated carbon-coated silver nanoparticles;

[0059] (4) Preparation of carboxymethyl chitosan: Grind and premix 100 g of chitosan powder, 1 g of sodium propoxide solid and 400 g of monochloroacetic acid evenly, then place them in an ultrasonic system at 50 °C and a vacuum degree of -0.01 Mpa for reaction for 40 min; after the reaction, take out the reaction mixture and make it into a 10% aqueous solution with distilled water, filter out a small amount of water-soluble substances, and then use a dialysis membrane to dialyze the filtrate to remove by-products such as sodium chloride, sodium chloroacetate, and chloroacetic acid generated during the reaction. The product after dialysis and impurity removal is carboxymethyl chitosan;

[0060] (5) Preparation of carboxymethyl chitosan-loaded activated carbon-coated silver nanoparticles: Add 10 g of activated carbon-coated silver nanoparticles to 40 g of carboxymethyl chitosan liquid, stir and mix, then perform centrifugation, and then freeze-dry to obtain an antibacterial agent.

[0061] Preparation Example 4

[0062] This preparation example discloses an antibacterial agent, including the following steps:

[0063] (1) Preparation of silver nanoparticles: Add 28 g of zirconium phosphate and 7 g of citric acid to 100 g of deionized water to prepare a suspension, then add 1 g of silver nitrate, stir for 18 h, and then perform filtration, drying, calcination, and pulverization to obtain silver nanoparticles with a particle size of 5 nm; the calcination temperature is 800 °C and the time is 2.5 h;

[0064] (2) Preparation of activated carbon-coated silver nanoparticles: Mix 90 g of silver nanoparticles and 10 g of medical activated carbon evenly to form a mixture, and place the mixture in a vacuum drying oven for vacuum adsorption (the air pressure in the oven is -0.1 Mpa, the temperature is 70 °C, and the adsorption time is 15 h) to obtain activated carbon-coated silver nanoparticles;

[0065] (3) Preparation of carboxymethyl chitosan: Grind and premix 100 g of chitosan powder, 0.5 g of sodium propoxide solid and 280 g of monochloroacetic acid evenly, then place them in an ultrasonic system at 50 °C and a vacuum degree of -0.01 Mpa for reaction for 40 min; after the reaction, take out the reaction mixture and make it into a 10% aqueous solution with distilled water, filter out a small amount of water-soluble substances, and then use a dialysis membrane to dialyze the filtrate to remove by-products such as sodium chloride, sodium chloroacetate, and chloroacetic acid generated during the reaction. The product after dialysis and impurity removal is carboxymethyl chitosan;

[0066] (4) Preparation of carboxymethyl chitosan-loaded activated carbon-coated silver nanoparticles: Add 10 g of activated carbon-coated silver nanoparticles to 40 g of carboxymethyl chitosan liquid, stir and mix, then perform centrifugation, and then freeze-dry to obtain an antibacterial agent.

[0067] Preparation Example 5

[0068] This preparation example discloses an antibacterial agent, including the following steps:

[0069] (1) Preparation of silver nanoparticles: Add 28 g of zirconium phosphate and 7 g of citric acid to 100 g of deionized water to prepare a suspension, then add 1 g of silver nitrate. After stirring for 18 h, filter, dry, calcine, and pulverize to obtain silver nanoparticles with a particle size of 5 nm; the calcination temperature is 800 °C and the time is 2.5 h;

[0070] (2) Preparation of activated carbon: Take 100 g of medical activated carbon, soak it in 300 ml of 0.1 mol / L HCl solution for 2 h, then place it in a water bath at room temperature and shake for 12 h. Rinse the activated carbon surface with distilled water until it is neutral, perform suction filtration, and dry at 100 °C for 3 h to obtain the treated activated carbon;

[0071] (3) Preparation of activated-carbon-coated silver nanoparticles: Mix 90 g of silver nanoparticles and 10 g of activated carbon evenly to form a mixture. Place the mixture in a vacuum drying oven for vacuum adsorption (the air pressure in the oven is -0.1 Mpa, the temperature is 70 °C, and the adsorption time is 15 h) to obtain activated-carbon-coated silver nanoparticles;

[0072] (4) Preparation of chitosan-loaded activated-carbon-coated silver nanoparticles: Add 10 g of activated-carbon-coated silver nanoparticles to 40 g of liquid chitosan, stir and mix, then perform centrifugation, and then freeze-dry to obtain the antibacterial agent.

[0073] Preparation Example 6

[0074] This preparation example discloses an antibacterial agent, which includes the following steps:

[0075] (1) Preparation of activated carbon: Take 100 g of medical activated carbon, soak it in 300 ml of 0.1 mol / L HCl solution for 2 h, then place it in a water bath at room temperature and shake for 12 h. Rinse the activated carbon surface with distilled water until it is neutral, perform suction filtration, and dry at 100 °C for 3 h to obtain the treated activated carbon;

[0076] (2) Preparation of activated-carbon-coated silver nanoparticles: Mix 90 g of silver nanoparticles and 10 g of activated carbon evenly to form a mixture. Place the mixture in a vacuum drying oven for vacuum adsorption (the air pressure in the oven is -0.1 Mpa, the temperature is 70 °C, and the adsorption time is 15 h) to obtain activated-carbon-coated silver nanoparticles; the silver nanoparticles are obtained by reducing silver nitrate with hydrazine hydrate;

[0077] (3) Preparation of carboxymethyl chitosan: 100 g of chitosan powder, 0.5 g of sodium propoxide solid and 280 g of monochloroacetic acid were ground and premixed evenly, and then placed in an ultrasonic system at 50 °C and a vacuum degree of -0.01 Mpa for reaction for 40 min; after the reaction, the reaction mixture was taken out and made into a 10% aqueous solution with distilled water, a small amount of water-soluble substances were filtered out, and then the filtrate was dialyzed with a dialysis membrane to remove by-products such as sodium chloride, sodium chloroacetate, and chloroacetic acid generated during the reaction. The product after dialysis and impurity removal was carboxymethyl chitosan;

[0078] (4) Preparation of carboxymethyl chitosan-loaded activated carbon-coated silver nanoparticles: 10 g of activated carbon-coated silver nanoparticles were added to 40 g of carboxymethyl chitosan liquid, stirred and mixed, then centrifuged, and then freeze-dried to obtain the antibacterial agent.

[0079] Preparation Example 7

[0080] This preparation example discloses an antibacterial agent, which includes the following steps:

[0081] (1) Preparation of silver nanoparticles: 28 g of zirconium phosphate and 7 g of citric acid were added to 100 g of deionized water to prepare a suspension, and then 1 g of silver nitrate was added. After stirring for 18 h, filtration, drying, calcination, and pulverization were carried out to obtain silver nanoparticles with a particle size of 5 nm; the calcination temperature was 800 °C and the time was 2.5 h;

[0082] (2) Preparation of activated carbon: 100 g of medical activated carbon was soaked in 300 ml of 0.1 mol / L HCl solution for 2 h, then placed in a water bath at room temperature and shaken for 12 h, rinsed with distilled water until the surface of the activated carbon was neutral, filtered by suction, and dried at 100 °C for 3 h to obtain the treated activated carbon;

[0083] (3) Preparation of activated carbon-coated silver nanoparticles: 90 g of silver nanoparticles and 10 g of activated carbon were mixed evenly to form a mixture, and the mixture was placed in a vacuum drying oven for vacuum adsorption (the air pressure in the oven was -0.1 Mpa, the temperature was 70 °C, and the adsorption time was 15 h) to obtain activated carbon-coated silver nanoparticles.

[0084] Preparation Example 8

[0085] This preparation example discloses an antibacterial agent, which includes the following steps:

[0086] (1) Preparation of carboxymethyl chitosan: 100 g of chitosan powder, 0.5 g of sodium propoxide solid and 280 g of monochloroacetic acid were ground and premixed evenly, and then placed in an ultrasonic system at 50 °C and a vacuum of -0.01 Mpa for reaction for 40 min; after the reaction, the reaction mixture was taken out and made into a 10% aqueous solution with distilled water, a small amount of water-soluble substances were filtered out, and then the filtrate was dialyzed with a dialysis membrane to remove by-products such as sodium chloride, sodium chloroacetate, and chloroacetic acid generated during the reaction. The product after dialysis and impurity removal was carboxymethyl chitosan.

[0087] Example

[0088] Example 1

[0089] As shown in Table 1, the main difference between Examples 1-11 lies in the different raw material ratios of the antibacterial medical silicone gel.

[0090] The following takes Example 1 as an example for illustration. The specific formula of the antibacterial medical silicone gel in this example is: 900 g of methyl vinyl siloxane-dimethyl siloxane copolymer (vinyl silicone oil), 30 g of polymethylhydrosiloxane (hydrogen-containing silicone oil), 5 g of silane coupling agent KH570, 5 g of platinum catalyst, and 10 g of antibacterial agent, and the antibacterial agent is obtained from Preparation Example 1.

[0091] This example also discloses a preparation method of an antibacterial medical silicone gel, including the following steps:

[0092] (1) Weigh according to the formula, mix half of the methyl vinyl siloxane-dimethyl siloxane copolymer and the platinum catalyst to obtain A glue; mix the polymethylhydrosiloxane, silane coupling agent KH570 and the other half of the methyl vinyl siloxane-dimethyl siloxane copolymer to obtain B glue;

[0093] (2) Mix A glue, B glue and the antibacterial agent with a mass ratio of 1:1 to obtain the antibacterial silicone gel.

[0094] This example also discloses a medical tape prepared from the above antibacterial silicone gel.

[0095] This example also discloses a preparation method of a medical tape, specifically: coat the above-prepared antibacterial silicone gel on the surface of the non-woven fabric at a coating amount of 150 g / m 2 to form a medical tape.

[0096] Table 1 Raw material ratios of antibacterial medical silicone gel in Examples 1-11

[0097]

[0098] Example 12

[0099] This example is basically the same as Example 10, except that the antibacterial agent is obtained from Preparation Example 2.

[0100] Example 13

[0101] This example is basically the same as Example 10, except that the antibacterial agent is obtained from Preparation Example 3.

[0102] Example 14

[0103] This example is basically the same as Example 10, except that the antibacterial agent is obtained from Preparation Example 4.

[0104] Comparative Example

[0105] Comparative Example 1

[0106] The difference between this comparative example and Example 1 is that the specific formula of the medical silicone gel disclosed in this comparative example is: 900 g of methyl vinyl siloxane-dimethyl siloxane copolymer (vinyl silicone oil), 30 g of polymethylhydrosiloxane (hydrogen-containing silicone oil), 5 g of silane coupling agent KH570, and 5 g of platinum catalyst.

[0107] Comparative Example 2

[0108] The difference between this comparative example and Example 1 is that the specific formula of the medical silicone gel disclosed in this comparative example is: 900 g of methyl vinyl siloxane-dimethyl siloxane copolymer (vinyl silicone oil), 30 g of polymethylhydrosiloxane (hydrogen-containing silicone oil), 5 g of silane coupling agent KH570, 5 g of platinum catalyst, and 10 g of antibacterial agent, where the antibacterial agent is obtained from Preparation Example 5.

[0109] Comparative Example 3

[0110] The difference between this comparative example and Example 1 is that the specific formula of the medical silicone gel disclosed in this comparative example is: 900 g of methyl vinyl siloxane-dimethyl siloxane copolymer (vinyl silicone oil), 30 g of polymethylhydrosiloxane (hydrogen-containing silicone oil), 5 g of silane coupling agent KH570, 5 g of platinum catalyst, and 10 g of antibacterial agent, where the antibacterial agent is obtained from Preparation Example 6.

[0111] Comparative Example 4

[0112] The difference between this comparative example and Example 1 is that the specific formula of the medical silicone gel disclosed in this comparative example is: 900 g of methyl vinyl siloxane-dimethyl siloxane copolymer (vinyl silicone oil), 30 g of polymethylhydrosiloxane (hydrogen-containing silicone oil), 5 g of silane coupling agent KH570, 5 g of platinum catalyst, and 10 g of antibacterial agent, where the antibacterial agent is obtained from Preparation Example 7.

[0113] Comparative Example 5

[0114] The difference between this comparative example and Example 1 lies in that: the specific formula of the medical silicone gel disclosed in this comparative example is as follows: 900 g of methyl vinyl siloxane-dimethyl siloxane copolymer (vinyl silicone oil), 30 g of polymethylhydrogensiloxane (hydrogen-containing silicone oil), 5 g of silane coupling agent KH570, 5 g of platinum catalyst, and 10 g of antibacterial agent, wherein the antibacterial agent is obtained from Preparation Example 8.

[0115] Performance Testing

[0116] 1. Antibacterial performance test: Take Escherichia coli, activate and culture it at 37 °C and 220 rpm. After culturing for 12 h, dilute the bacterial suspension until the concentration reaches 10 8 cfu / ml, add an equal volume of the silicone gel of each example and comparative example, and record the size of the inhibition zone after culturing for 12 h to characterize the antibacterial performance. The results are shown in Table 2.

[0117] 2. Adhesion performance test: Cut the medical tapes prepared in each example and comparative example into sample strips, stick them on white cardboard, and then perform 180° peeling with a tensile machine to see how much glue remains on the white cardboard. It is divided into three grades: poor adhesion to the substrate, general, and good; when the adhesion performance is poor, the glue comes off in pieces on the white cardboard; when it is general, a small amount of glue comes off on the white cardboard; when it is good, no glue comes off on the white cardboard. The results are shown in Table 2.

[0118] Table 2 Data table of performance testing of Examples 1-14 and Comparative Examples 1-5

[0119]

[0120] Referring to Table 2 and combining Examples 1-14 and Comparative Example 1, it can be seen that by adding an appropriate amount of antibacterial agent to the medical silicone gel in this application, the antibacterial property of the prepared silicone gel can be effectively improved; silver element can block the electron transport inside bacteria, increase the stability of bacterial DNA, thereby weakening the cell replication of bacteria; silver can also destroy the structure and receptor function of bacteria, forming insoluble ineffective metabolic compounds, thus contributing to the prevention and control of infection and not generating drug resistance; at the same time, silver element can also reduce the inflammation on the wound surface and promote wound healing. Chitosan has the effect of promoting blood coagulation and can be used as a hemostatic agent. It can also be used as a wound packing material and has the functions of sterilization and promoting wound healing. The antibacterial agent in this application effectively combines silver element and chitosan, improving the antibacterial property of the prepared silicone gel.

[0121] Referring to Table 2 and combining Examples 1 and 14, it can be seen that by acidifying the activated carbon in this application, its specific surface area and pore volume increase, so the adsorption property for nano silver particles is higher, and the release rate also increases relatively, further improving the antibacterial performance of the antibacterial agent, thus making the antibacterial property of the silicone gel better.

[0122] Referring to Table 2, in combination with Example 1 and Comparative Example 2, it can be seen that in this application, by subjecting chitosan to carboxymethylation modification and using sodium alkoxide as a catalyst to catalyze the de-HCl small molecule reaction between chitosan and monochloroacetic acid, carboxymethyl chitosan with a high yield and a high degree of substitution can be obtained. This method avoids the large-scale use of organic solvents and quickly evaporates the HCl small molecules generated in the system, ensuring that the reaction continuously moves forward in the positive direction, and can effectively improve the yield. In this application, the one-step solid-phase reaction method is used to subject chitosan to carboxymethylation modification to obtain a high yield and high purity, thereby improving the synergistic antibacterial effect with the activated carbon-coated nanoparticles and further enhancing the antibacterial property of the silicone gel.

[0123] Referring to Table 2, in combination with Example 1 and Comparative Example 3, it can be seen that the silver nanoparticles in this application are prepared by exchanging and loading silver particles on zirconium phosphate. They are fine powders with uniform particle size, extremely low hygroscopicity, very high heat resistance, and stable physical and chemical properties. Compared with the silver nanoparticles prepared by the traditional method of reducing silver nitrate with hydrazine hydrate, they have a better antibacterial effect and can further improve the antibacterial property of the silicone gel.

[0124] Referring to Table 2, in combination with Example 1 and Comparative Examples 4 and 5, it can be seen that in this application, by compounding the activated carbon-coated silver nanoparticles with carboxymethyl chitosan to form a composite antibacterial agent, the composite antibacterial agent combines the advantages of organic antibacterial agents and inorganic antibacterial agents, overcomes the defects of single antibacterial components, and the organic and inorganic components produce a synergistic effect to enhance the antibacterial effect. Adding it to the silicone gel can improve the antibacterial property of the silicone gel.

[0125] This specific embodiment is only an interpretation of this application and does not limit this application. After reading this specification, those skilled in the art can make modifications to this embodiment that do not contribute creatively according to needs, but as long as they are within the scope of the claims of this application, they are protected by the patent law.

Claims

1. An antibacterial medical silicone gel, characterized in that: it comprises the following raw materials in parts by weight: 90 - 95 parts of vinyl silicone oil, 3 - 8 parts of hydrogen-containing silicone oil, 0.5 - 5 parts of tackifier, 1 - 3 parts of antibacterial agent, and 0.5 - 3 parts of metal catalyst; the antibacterial agent is composed of activated carbon-coated silver nanoparticles and carboxymethyl chitosan; The preparation method of the silver nanoparticles includes the following steps: adding 25 - 30 parts by weight of zirconium phosphate and 5 - 10 parts by weight of citric acid to 100 parts by weight of deionized water to prepare a suspension, then adding 0.8 - 1.3 parts by weight of silver nitrate, stirring for 12 - 24 h, filtering, drying, calcining, and pulverizing to obtain the silver nanoparticles; The preparation method of the antibacterial agent includes the following steps: Mixing silver nanoparticles and activated carbon with a mass ratio of 85 - 95:5 - 15 to form a mixture, subjecting the mixture to vacuum adsorption to obtain activated carbon-coated silver nanoparticles; adding the activated carbon-coated silver nanoparticles to carboxymethyl chitosan, followed by centrifugation and freeze-drying to obtain the antibacterial agent.

2. The antibacterial medical silicone gel according to claim 1, characterized in that: The preparation method of the activated carbon is as follows: taking medical activated carbon, soaking it in an acid solution, placing it in a water bath at room temperature for oscillation, then washing it with water until the surface of the activated carbon is neutral, and then performing suction filtration and drying to obtain the activated carbon.

3. The antibacterial medical silicone gel according to claim 1, characterized in that: The preparation method of the carboxymethyl chitosan is as follows: grinding and mixing chitosan, sodium alkoxide, and monochloroacetic acid with a mass ratio of 100:0.1 - 1:150 - 400, reacting under heating and ultrasonic treatment conditions, and separating to obtain the carboxymethyl chitosan after the reaction ends.

4. The antibacterial medical silicone gel according to claim 1, characterized in that: The tackifier is a silane coupling agent.

5. The antibacterial medical silicone gel according to claim 1, characterized in that: The metal in the metal catalyst includes one or more of ruthenium, rhodium, palladium, osmium, and platinum.

6. The preparation method of the antibacterial medical silicone gel according to any one of claims 1 - 5, characterized in that: it includes the following steps: Mixing part of the vinyl silicone oil with the metal catalyst to obtain A glue; Mixing the hydrogen-containing silicone oil, tackifier, and the remaining vinyl silicone oil to obtain B glue; Mixing A glue, B glue, and the antibacterial agent to obtain the antibacterial silicone gel.

7. Medical tape, characterized in that: it includes the antibacterial medical silicone gel according to any one of claims 1 - 5.

8. The preparation method of the medical tape according to claim 7, characterized in that: coating the antibacterial medical silicone gel on a substrate to obtain it.

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