Electrode patch, manufacturing method thereof, and tumor electric field therapy apparatus

Abstract

The present invention provides an electrode patch for treating tumors by means of an electric field, which comprises at least one electrode unit, an adapter plate detachably connected to at least one of the electrode units, and a backing adhered to corresponding parts of at least one of the electrode units and the adapter plate. The electrode patch of the present invention is composed of at least one electrode unit detachably connected to the adapter plate, and can realize detachable replacement of a failed electrode unit on the electrode patch or detachable replacement of a failed adapter plate on the electrode patch, reduce the loss of the entire electrode patch, and reduce the yield loss of the electrode patch.

Description

[0001] This application is a divisional application of the invention patent application with the application date of December 26, 2022, application number 202211678871.X, and invention creation name of "Electrode Patch, Manufacturing Method of Electrode Patch and Tumor Electric Field Therapeutic Instrument". Technical Field

[0002] This application relates to an electrode patch, a manufacturing method of the electrode patch and a tumor electric field therapeutic instrument, belonging to the technical field of medical devices. Background Art

[0003] Currently, the main treatment methods for tumors include surgery, radiotherapy, chemotherapy, etc., but they all have corresponding drawbacks. For example, radiotherapy and chemotherapy will produce side effects and kill normal cells. Using electric fields to treat tumors is also one of the current research fronts. Tumor electric field therapy is a tumor treatment method that uses a special electric field generator to generate a low-intensity, medium-high frequency, alternating electric field to interfere with the mitotic process of tumor cells. Research shows that electric field therapy is effective in the treatment of diseases such as glioblastoma, non-small cell lung cancer, and malignant pleural mesothelioma. The electric field applied by this treatment method can affect the aggregation of tubulin, prevent the formation of the spindle, inhibit the mitotic process, and induce apoptosis of cancer cells.

[0004] The tumor electric field therapeutic instrument for treating tumors mainly includes an electric field generator and electrode patches electrically connected to the electric field generator. Among them, the electrode patches are paired and attached to the human skin to apply an alternating electric field to the human lesion for alternating electric field treatment. Each electrode patch includes a flexible circuit board, a plurality of ceramic chips spaced on the flexible circuit board, and wires electrically connected to the flexible circuit board, as disclosed in Chinese Invention Patent Publication No. 11271272 or No. 113164745. The flexible circuit board includes a flexible board substrate, a plurality of conductive traces embedded in the flexible board substrate, and a plurality of conductive pads exposed on the flexible board substrate and electrically connected by the same conductive trace. The plurality of ceramic chips are provided on the flexible circuit board by welding to the corresponding conductive disks, and then are connected in series through a conductive trace electrically connected to all the conductive disks. One end of the wire is electrically connected to the flexible circuit board, and the other end is provided with a plug that can be plugged into the electric field generator.

[0005] Since the ceramic sheet is a hard material and the flexible printed circuit board is a flexible material, the mechanical strength of the flexible printed circuit board of the electrode patch of the above tumor electric field treatment system is stronger at the part where a plurality of ceramic sheets are arranged at intervals than at the part where no ceramic sheet is arranged. Furthermore, there is a risk of bending at the junction between the part where the ceramic sheet is arranged and the part where no ceramic sheet is arranged on the flexible printed circuit board. If the bending is severe, there is also a risk of breakage of the conductive traces in the flexible board substrate. The plurality of ceramic sheets of the electrode patch are connected in series through the same conductive trace of the flexible circuit board, and there will be a situation where the electrical signal cannot be transmitted to all the ceramic sheets due to the breakage of the conductive trace of this path of the flexible circuit board, resulting in the overall scrapping of the electrode patch during manufacturing due to unqualified detection, inability to be used and reused, low product manufacturing yield, and increased manufacturing cost.

[0006] Therefore, it is indeed necessary to provide an improved electrode patch and a tumor electric field treatment instrument to solve the technical problems existing in the electrode patch of the above tumor electric field treatment instrument. Summary of the Invention

[0007] The present invention provides an electrode patch that can avoid the scrapping of the entire electrode patch, a manufacturing method of the electrode patch, and a tumor electric field treatment instrument.

[0008] In view of the problems existing in the prior art, an electrode patch provided by the present invention is realized through the following technical solutions: An electrode patch for tumor electric field treatment includes at least one electrode unit, an adapter board formed by a flexible printed circuit board, and a back lining. The electrode unit and the adapter board are both pasted on the back lining. The electrode unit includes a flexible board substrate and a ceramic transducer. A male socket is provided on the flexible board substrate, and the ceramic transducer and the male socket are respectively located at opposite ends of the flexible board substrate. At least one female socket is provided on the adapter board, and the male socket and the female socket are plugged together to make the electrical connection between the electrode unit and the adapter board detachable; The adapter board includes a body, the body includes a main trunk and branches, both the main trunk and the branches are provided with the female sockets, the main trunk is provided with at least one through-shaped hollow hole, and when the male socket and the female socket are plugged together, the hollow hole allows the ceramic transducer of the corresponding electrode unit to pass through. There is a gap between the two branches, and when the male socket and the female socket are plugged together, the gap allows the ceramic transducer of the corresponding electrode unit to pass through.

[0009] Furthermore, each electrode unit includes support plates respectively arranged on both sides of the flexible board substrate with the ceramic transducer, and the male socket is provided on the flexible board substrate and is on the same side surface of the flexible board substrate as the ceramic transducer.

[0010] Furthermore, the ceramic transducer and the support plate are both located at the same end of the flexible board substrate.

[0011] Further, the electrode unit further includes a temperature sensor disposed on the flexible plate substrate and on the same side as the ceramic transducer

[0012] Further, the ceramic transducer has a through-opening, and the temperature sensor is received in the opening of the ceramic transducer.

[0013] Further, the electrode unit and the adapter plate are pasted on the backing in a partially overlapping manner, and the male seat and the corresponding female seat are located at the overlapping part.

[0014] Further, the adapter plate includes a wiring portion connected to the body, and the wiring portion is located at one end of the body.

[0015] Further, there is one main trunk.

[0016] Further, the hollow hole is correspondingly arranged with the corresponding female seat.

[0017] Further, when the ceramic transducer of the electrode unit is disposed on the adapter plate, the ceramic transducer of the electrode unit exposes to the side of the adapter plate away from the female seat.

[0018] Further, there are multiple branches, and the multiple branches are located on both sides of the main trunk.

[0019] Further, there is a gap allowing the ceramic transducer of the corresponding electrode unit to pass through between two adjacent branches on the same side of the main trunk, and the ceramic transducer of the electrode unit exposes to the side of the adapter plate away from the female seat after passing through the gap.

[0020] Further, the electrode patch further includes a wire electrically connected to the wiring portion of the adapter plate, one end of the wire is electrically connected to the wiring portion of the adapter plate, and the other end is provided with a plug.

[0021] Further, a heat shrinkable tube is also wrapped around the periphery of the connection between the wire and the wiring portion.

[0022] Further, the plug of the wire is also detachably plugged into an adapter cable.

[0023] Further, the backing is in a sheet shape and has at least one through-hole corresponding to the electrode unit and arranged in a through manner, and the through-hole of the backing allows the corresponding part of the electrode unit to expose from the side surface of the backing away from the adapter plate.

[0024] Furthermore, the electrode patch also includes a support member that surrounds the corresponding part of the electrode unit and is adhered to the backing, and an adhesive member that covers the support member and the corresponding part of the electrode unit and is adhered to the body surface skin corresponding to the tumor site of the patient.

[0025] Furthermore, the support member has at least one through hole arranged in a penetrating shape.

[0026] Furthermore, the through-holes include first through-holes corresponding to the corresponding electrode units and accommodating corresponding parts of the corresponding electrode units.

[0027] Furthermore, the perforations further include a second perforation located between the plurality of the first perforations and opposite to the adapter plate.

[0028] Furthermore, the electrode patch also includes at least one release paper located on a side of the adhesive component away from the backing and covering the adhesive component and the backing.

[0029] The present invention also provides a method for manufacturing the electrode patch. The method for manufacturing the electrode patch provided by the present invention is implemented by the following technical solution: A method for manufacturing an electrode patch, comprising the following steps:

[0030] S11, providing an adapter board, wherein the adapter board has at least one set of third pads and a wiring portion;

[0031] S12, providing at least one female socket, and welding the female sockets to corresponding third pads of the adapter board respectively;

[0032] S13, providing a wire, and placing the wire group at the connection part of the adapter board;

[0033] S14, providing a heat shrink tubing, and covering the heat shrink tubing at the connection between the adapter plate and the wire;

[0034] S15, providing at least one electrode unit detachably connected to the adapter plate, and clamping the electrode unit to the female socket on the adapter plate;

[0035] S16, providing a backing, and gluing the corresponding part of the surface of one side of the adapter plate on which the mother seat is set after the above steps and the surface of the electrode unit on the same side onto the backing.

[0036] Furthermore, after step S16, the following steps are also included:

[0037] S17, providing a support member, and bonding the support member to the backing so as to surround the corresponding part of the electrode unit;

[0038] S18, providing an adhesive member, and adhering the adhesive member to the surface of the supporting member and the corresponding part of the electrode unit away from the backing;

[0039] S19. Provide a release paper and cover the release paper on the surfaces of the backing and the pasting member close to the patient's skin side.

[0040] Furthermore, the manufacturing method of the electrode unit includes the following steps:

[0041] S21. Provide a flexible board substrate. One end of the flexible board substrate has a plurality of conductive pads arranged at intervals and two first pads located within the area surrounded by the plurality of conductive pads, and the other end has a plurality of second pads;

[0042] S22. Provide a support board and respectively assemble the support board on the flexible board substrate in a one-to-one correspondence with the plurality of conductive pads. The support board and the conductive pads are respectively located on opposite sides of the flexible board substrate;

[0043] S23. Provide a temperature sensor and weld the temperature sensor on the two first pads;

[0044] S24. Provide a ceramic transducer with an opening and weld the ceramic transducer on the plurality of conductive pads in such a way that the corresponding temperature sensor is received within the opening;

[0045] S25. Provide a male socket and weld the male socket on the plurality of second pads.

[0046] The tumor electric field treatment apparatus provided by the present invention is realized through the following technical solution: A tumor electric field treatment apparatus includes an electric field generator and at least a pair of the above-mentioned electrode patches electrically connected to the electric field generator.

[0047] Furthermore, it further includes an adapter electrically connected between the electrode patch and the electric field generator.

[0048] The electrode patch of the tumor electric field treatment apparatus of the present invention is detachably connected and composed of at least one electrode unit and an adapter board, which can realize detachable replacement of the failed electrode unit on the electrode patch or detachable replacement of the failed adapter board on the electrode patch, avoid replacement of the whole electrode patch, and reduce the yield loss of the electrode patch. Description of the Drawings

[0049] Figure 1 It is a schematic diagram of an electrode patch of a tumor electric field treatment apparatus according to the first embodiment of the present invention;

[0050] Figure 2A For Figure 1 the exploded view schematic diagram of the electrode unit in

[0051] Figure 2B For Figure 1 the combined schematic diagram of the electrode unit in

[0052] Figure 3 The wiring diagram of the flexible plate substrate of the electrode unit in Figure 2A ;

[0053] Figure 4 The Figure 1 structural schematic diagram of the adapter board in

[0054] Figure 5A The Figure 4 front wiring diagram of the adapter board in

[0055] Figure 5B The Figure 4 reverse wiring diagram of the adapter board in

[0056] Figure 6A The Figure 1 schematic diagram of the electrode patch in , where the support and the adhesive are not shown;

[0057] Figure 6B The Figure 1 schematic diagram of another perspective of the electrode patch in , where the support and the adhesive are not shown;

[0058] Figure 7 The Figure 1 combined schematic diagram of the electrode unit, the adapter board, the wire, the backing and the support in ;

[0059] Figure 8A The Figure 1 overall schematic diagram of the electrode patch in ;

[0060] Figure 8B The Figure 1 overall schematic diagram of another perspective of the electrode patch in ;

[0061] Figure 9A The exploded schematic diagram of the electrode patch of the tumor electric field treatment instrument according to the second embodiment of the present invention, where the release paper is not shown;

[0062] Figure 9B The Figure 9A combined schematic diagram of the electrode patch shown in , where the release paper is not shown;

[0063] Figure 10A The Figure 9A exploded schematic diagram of the adapter board and the wire in ;

[0064] Figure 10B The Figure 10A combined schematic diagram of the adapter board and the wire in ;

[0065] Figure 11A The Figure 10A front wiring diagram of the adapter board in ;

[0066] Figure 11B The reverse side wiring diagram of the adapter board in Figure 10A ;

[0067] Figure 12 The schematic flow chart of the manufacturing method of the electrode patch of the tumor electric field treatment apparatus according to the present invention;

[0068] Figure 13 is Figure 12 The schematic flow chart of the manufacturing method of the electrode unit of the electrode patch described in Detailed Description of the Invention

[0069] Here, the exemplary embodiments will be described in detail, and the examples are shown in the drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. On the contrary, they are merely examples of devices, apparatuses, systems, and methods consistent with some aspects of the present application as detailed in the appended claims.

[0070] The tumor electric field treatment apparatus (not shown) of the present invention includes an electric field generator (not shown) and electrode patches 100, 100' connected to the electric field generator (not shown). The electrode patches 100, 100' are attached to the surface of the human skin, and the treatment electric field generated by the electric field generator (not shown) is applied to the human body for tumor electric field treatment. The electrode patches 100, 100' of the embodiments of the present application are attached to the human head for use in assisting the treatment of brain tumors, such as glioblastoma multiforme. In other embodiments, a connector (not shown) may also be provided between the electrode patches 100, 100' of the tumor electric field treatment apparatus (not shown) and the electric field generator (not shown). The connector (not shown) is electrically connected between the electrode patches 100, 100' and the electric field generator (not shown).

[0071] Figure 1As shown in FIGS. 1 to 8, the electrode patch 100 of the first embodiment of the present invention is shown. The electrode patch 100 can be directly plugged into an electric field generator (not shown) to achieve electrical connection with the electric field generator (not shown), or can be directly plugged into an adapter (not shown), and then electrically connected to the electric field generator (not shown) through the adapter (not shown) to achieve electrical connection with the electric field generator (not shown). The electrode patch 100 includes at least one electrode unit 10, an adapter plate 20 detachably connected to the at least one electrode unit 10, a wire 30 electrically connected to the adapter plate 20, a backing 40 pasted to corresponding parts of the electrode unit 10 and the adapter plate 20, a support member 50 surrounding a corresponding part of the electrode unit 10 and pasted to the backing 40, and a paste member 60 covering the support member 50 and the corresponding part of the electrode unit 10 and fitting to the body surface skin corresponding to the patient's tumor site. The electrode patch 100 is attached to the body surface corresponding to the patient's tumor site through the backing 40, and an alternating electric field is applied to the patient's tumor site through at least one electrode unit 10 detachably connected to the adapter plate 20 to interfere with or prevent the mitosis of the patient's tumor cells, thereby achieving the purpose of treating tumors. In the present invention, the electrode patch 100 is composed of at least one electrode unit 10 detachably connected to the adapter plate 20, which can achieve detachable replacement of a failed electrode unit 10 or a failed adapter plate 20, can reduce the loss of the entire electrode patch 100 before the product is shipped, reduce the yield loss of the electrode patch 100, and can avoid scrapping the entire electrode patch 100 during the use of the electrode patch 100, saving costs; it can also freely select the number of electrode units 10 plugged onto the adapter plate 20 to adaptively adjust the intensity of the alternating electric field applied through the electrode patch 100 according to the size of the tumor.

[0072] Reference Figure 2A With Figure 2B , each electrode unit 10 includes a flexible plate substrate 11, a support plate 13 and a ceramic transducer 12 respectively provided on both sides of the flexible plate substrate 11, and a male seat 15 provided on the surface of the flexible plate substrate 11 on the same side as the ceramic transducer 12. The ceramic transducer 12 and the male seat 15 are located at opposite ends of the flexible plate substrate 11, and the ceramic transducer 12 and the support plate 13 are located at the same end of the flexible plate substrate 11. In this embodiment, the sizes of the support plate 13 and the ceramic transducer 12 are slightly smaller than the size of the flexible plate substrate 11.

[0073] The ceramic transducer 12 is made of a high dielectric constant material, which has the conductive property of blocking the conduction of direct current and allowing alternating current to pass through, and can ensure the safety of the user during tumor electric field therapy. A through hole 121 is provided at the center of the ceramic transducer 12. The electrode unit 10 further includes a temperature sensor 14 disposed on the flexible board substrate 11 and on the same side as the ceramic transducer 12. The temperature sensor 14 is received in the through hole 121 at the center of the ceramic transducer 12 for sensing the temperature of the patient's skin in contact with the electrode patch 100. The temperature sensor 14 has a ground terminal 14A and a signal terminal 14B. Preferably, the temperature sensor 14 is a thermistor.

[0074] Reference Figure 3 , three first conductive traces 114 are embedded in the flexible board substrate 11. The three first conductive traces 114 include a first ground wire 114A electrically connected to both the ground terminal 14A of the temperature sensor 14 and the male socket 15, a first signal wire 114B for transmitting temperature signals electrically connected to both the signal terminal 14B of the temperature sensor 14 and the male socket 15, and a first AC wire 114C arranged in a ring shape and electrically connected to the ceramic transducer 12 and the male socket 15. The first ground wire 114A and the first signal wire 114B are both arranged to extend along the length direction of the flexible board substrate 11. The first AC wire 114C is arranged in a closed ring shape along the periphery of the flexible board substrate 11, including a first AC wire segment 115 arranged in an arc shape at the same end as the ceramic transducer 12 and a second AC wire segment 116 extending from the first AC wire segment 115 and arranged in an inverted "Π" shape. The first AC wire segment 115 is electrically connected to the ceramic transducer 12 disposed on the flexible board substrate 11. One end of the second AC wire segment 116 is connected to the opposite two ends of the first AC wire segment 115, and the other end is welded to the male socket 15 disposed on the flexible board substrate 11. The electrical connection between the ceramic transducer 12 and the male socket 15 is achieved through the electrical connection between the ceramic transducer 12 and the first AC wire segment 115 of the first AC wire 114C of the flexible board substrate 11, the connection between the first AC wire segment 115 and one end of the second AC wire segment 116 of the first AC wire 114C of the flexible board substrate 11, and the electrical connection between the other end of the second AC wire segment 116 of the first AC wire 114C of the flexible board substrate 11 and the male socket 15.

[0075] The second AC line segment 116 is formed by extending the two opposite ends of the first AC line segment 115 respectively along the length direction of the flexible board substrate 11 and then closing at the end far from the first AC line segment 115. The second AC line segment 116 first extends away from the ceramic transducer 12 from one end of the first AC line segment 115, then bends and extends towards the other end of the first AC line segment 115, and then extends towards the other end of the first AC line segment 115 until it is connected to the other end of the first AC line segment 115. The second AC line segment 116 includes a part extending from one end of the first AC line segment 115 and having an "L" - shaped structure, and a part extending from the other end of the first AC line segment 115 and having an "I" - shaped structure. The second AC line segment 116 has two parts respectively connected to the two opposite ends of the first AC line segment 115. When one part is disconnected from one end of the first AC line segment 115 due to bending, it can be connected to the other end of the first AC line segment 115 through its other part to ensure the electrical connection between it and the first AC line segment 115, and further achieve a good and stable electrical connection between the ceramic transducer 12 and the male socket 15. That is, the second AC line segment 116 of the first AC line 114C is connected to the two opposite ends of the arc - shaped first AC line segment 115 at the same time. Even when the second AC line segment 116 is disconnected from one end of the first AC line segment 115 due to bending, the electrical signal can still be transmitted to the ceramic transducer 12 through the connection between the second AC line segment 116 and the other end of the first AC line segment 115, ensuring the reliability of the electrical connection between the ceramic transducer 12 of the electrode unit 10 and the flexible board substrate 11, improving the product quality and reducing the defective rate of the product. The first ground wire 114A and the first signal wire 114B are both located within the area surrounded by the first AC line 114C, which is convenient for wiring and reduces the wiring difficulty.

[0076] On the same side surface of the flexible board substrate 11, there are also provided a plurality of conductive pads 111 arranged at intervals and welded to the ceramic transducer 12, two first pads 112 respectively welded to the ground terminal 14A and the signal terminal 14B of the temperature sensor 14, and a plurality of second pads 113 welded to the male socket 15. The conductive pads 111 and the first pads 112 are both located at the same end of the flexible board substrate 11, and the second pads 113 are located at the other end of the flexible board substrate 11. The plurality of conductive pads 111 are respectively electrically connected to the first AC line segment 115 of the first AC line 114C embedded in the flexible board substrate 11 and are connected in series through the arc - shaped first AC line segment 115. The flexible board substrate 11 realizes its electrical connection with the ceramic transducer 12 through the electrical connection between the first AC line segment 115 of the first AC line 114C and the conductive pads 111 and the welding between the conductive pads 111 and the ceramic transducer 12.

[0077] Two first pads 112 are located at the intermediate position surrounded by a plurality of conductive pads 111. The first pad 112 welded to the ground terminal 14A of the temperature sensor 14 is the first pad 112A, and the first pad 112 welded to the signal terminal 14B of the temperature sensor 14 is the first pad 112B. The first pad 112A is provided at the end of the first ground wire 114A within the first AC segment 115 of the first AC wire 114C, and the first pad 112B is provided at the end of the first signal wire 114B within the first AC segment 115 of the first AC wire 114C. The first pad 112A is electrically connected to one end of the first ground wire 114A, and the first pad 112B is electrically connected to one end of the first signal wire 114B. The flexible board substrate 11 realizes its electrical connection with the temperature sensor 14 by welding the ground terminal 14A of the temperature sensor 14 through the first pad 112A connected to the first ground wire 114A and welding the signal terminal 14B of the temperature sensor 14 through the first pad 112B connected to the first signal wire 114B.

[0078] The second pad 113 and the first pad 112 are respectively disposed at opposite ends of the flexible board substrate 11. The second pad 113 is disposed at one end of the flexible board substrate 11 away from the ceramic transducer 12 and is welded to the male socket 15 to achieve electrical connection between it and the male socket 15. There are at least 3 second pads 113, including a second pad 113A electrically connected to the first pad 112A through the first ground wire 114A, a second pad 113B electrically connected to the first pad 112B through the first signal wire 114B, and at least one second pad 113C electrically connected to the conductive disk 111 through the first AC wire 114. The second pad 113A and the first pad 112A are respectively disposed at opposite ends of the first ground wire 114A, and electrical connection between the two is achieved through the first ground wire 114A. The second pad 113B and the first pad 112B are respectively disposed at opposite ends of the first signal wire 114B, and electrical connection between the two is achieved through the first signal wire 114B. The second pad 113C and the conductive disk 111 are respectively disposed at opposite ends of the first AC wire 114, and electrical connection between the two is achieved through the first AC wire 114. The second pad 113C is disposed at the end of the second AC segment 116 of the first AC wire 114, and the conductive disk 111 is disposed on the first segment 115 of the first AC wire 114. The flexible board substrate 11 is welded to the ceramic transducer 12 through the conductive disk 111 disposed on the first segment 115 of the first AC wire 114C, and the second pad 113C disposed at the end of the second segment 116 of the first AC wire 114C is welded to the male socket 15 to achieve electrical connection between the male socket 15 and the ceramic transducer 12. The flexible board substrate 11 is welded to the ground terminal 14A of the temperature sensor 14 through the first pad 112A disposed at one end of the first ground wire 114A, welded to the signal terminal 14B of the temperature sensor 14 through the first pad 112B disposed at one end of the first signal wire 114B, and the second pad 113A disposed at the other end of the first ground wire 114A and the second pad 113B disposed at the other end of the first signal wire 114B are both welded to the male socket 15 to achieve electrical connection between the temperature sensor 14 and the male socket 15.

[0079] There are at least three second pads 113 welded to the male seat 15, which can make the welding between the male seat 15 and the flexible board substrate 11 firm when the male seat 15 is welded to the flexible board substrate 11 through these second pads 113, ensuring a good electrical connection between the male seat 15 and the flexible board substrate 11. And the conductive pad 111 is welded to the male seat 15 through at least one second pad 113C on the second AC segment 116 of the first AC line 114C, which can ensure a stable electrical connection between the conductive pad 111 and the male seat 15, so as to transmit the electrical signal for tumor treatment to the conductive pad 111 through the first AC line 114C and then to the ceramic transducer 12 through the conductive pad 111. In this embodiment, four second pads 113C welded to the male seat 15 are respectively connected to the second AC segment 116 of the first AC line 114C. To achieve the purpose of strengthening the welding firmness between the male seat 15 and the flexible board substrate 11 in this application, there can be other implementation manners in this application. For example, one of the multiple second pads 113 is connected to the first ground wire 114A, one is connected to the second AC segment 116 of the first AC line 114C, and the remaining ones are respectively connected to the corresponding first signal lines 114B one by one. For another example, one of the multiple second pads 113 is connected to the first signal line 114B, one is connected to the first AC line 114C, and the remaining ones are respectively connected to the first ground wire 114A. That is, two of the multiple second pads 113 are respectively connected to two of the first ground wire 114A, the first signal line 114B and the first AC line 114C, and the remaining second pads 113 are all connected to the remaining one of the first ground wire 114A, the first signal line 114B and the first AC line 114C.

[0080] The ground signal of the temperature sensor 14 is transmitted to the corresponding second pad 113A electrically connected to the first ground wire 114A through the first ground wire 114A electrically connected to the ground terminal 14A; the temperature signal detected by the temperature sensor 14 is transmitted to the corresponding second pad 113B electrically connected to the first signal wire 114B through the first signal wire 114B electrically connected to its signal terminal 14B; and is welded to the male socket 15 through the second pad 113, the male socket 15 is inserted into the adapter board 20, the adapter board 20 is electrically connected to the wire 30, and the wire 30 is inserted into the electric field generator (not shown) to transmit the temperature signal detected by the temperature sensor 14 to the electric field generator (not shown), so as to achieve the purpose that the electric field generator (not shown) controls the alternating current signal transmitted to the ceramic transducer 12 through the detected temperature signal, and avoid the low-temperature scald of the patient's tumor surface caused by too high temperature. The AC signal generated by the electric field generator (not shown) is transmitted to the annular first AC wire 114C through the corresponding at least two second pads 113C, and then transmitted to the ceramic transducer 12 through the plurality of conductive pads 111 welded to the first AC wire 114C to apply an AC electrical signal to the tumor site for tumor electric field therapy. The AC signal required by the ceramic transducer 12 is an alternating current signal and is output by the electric field generator (not shown). The electric field generator (not shown) also outputs a direct current signal to the temperature sensor 14, so that the temperature sensor 14 is connected to the ground signal and operates to generate a temperature signal.

[0081] The support plate 13 is adhesively disposed on the surface of the flexible plate substrate 11 away from the conductive pad 111 by an adhesive (not shown). The support plate 13 and the ceramic transducer 12 correspond to each other in the thickness direction. The temperature sensor 14 is welded at a position corresponding to the flexible plate substrate and the two first pads 112. The ceramic transducer 12 is welded at a position corresponding to the flexible plate substrate 11 and the plurality of conductive pads 111. The male socket 15 is disposed at the position of the second pad 113 of the flexible plate substrate 11 by welding. The temperature sensor 14, the ceramic transducer 12, and the support plate 13 are all disposed at the same end of the flexible plate substrate 11. When welding the temperature sensor 14 and the ceramic transducer 12, the support plate 13 provides strength support for the flexible plate substrate 11, provides a flat welding plane for the welding operation between the flexible plate substrate 11 and the temperature sensor 14 and the ceramic transducer 12, and improves the product yield. A reinforcing plate 16 is adhesively disposed at one end of the flexible plate substrate 11 where the male socket 15 is welded. The reinforcing plate 16 is disposed on the surface of the flexible plate substrate 11 opposite to the male socket 15 to provide strength support for the flexible plate substrate 11 so that the male socket 15 can be welded thereto. At the same time, it also prevents the male socket 15 of the electrode unit 10 from causing the part at the welding joint of the flexible plate substrate 11 and the male socket 15 to bend when plugging and unplugging with the adapter plate 20, resulting in the fracture of the conductive trace embedded in the flexible plate substrate 11. The reinforcing plate 16 and the male socket 15 are respectively disposed on opposite sides of the flexible plate substrate 11. The reinforcing plate 16 and the male socket 15 are located at the same end of the flexible plate substrate 11.

[0082] The adapter plate 20 is provided with at least one female socket 25 corresponding to and electrically connected to the male socket 15 of the electrode unit 10. A plurality of electrode units 10 can be respectively plugged and combined with the corresponding female sockets 25 on the adapter plate 20 through the corresponding male sockets 15 to form an electrode patch 100 having at least one electrode unit 10. By the detachable combination of the electrode unit 10 and the adapter plate 20 in the present invention, it is possible to detachably replace a failed electrode unit 10 or a failed adapter plate 20, avoid the entire electrode patch 100 from being scrapped, reduce the yield loss of the electrode patch 100; avoid the entire electrode patch 100 from being scrapped, avoid waste, and reduce costs; at the same time, it is also possible to freely combine and select the number of electrode units 10 plugged into the adapter plate 20 to increase or decrease the electric field strength generated by the electrode patch 100, thereby ensuring that the electric field strength required for the patient's tumor site is generated by the electrode patch 100.

[0083] The adapter board 20 is arranged in a sheet shape, and it has a body 28 for plugging and combining at least one electrode unit 10 and a wiring part 27 for electrically connecting a wire 30. The wiring part 27 is integrally arranged with the body 28. The wiring part 27 is located at one end of the side of the body 28. The female socket 25 plugged with the male socket 15 of the electrode unit 10 is arranged on the body 28 by welding. The wire 30 realizes its electrical connection with the adapter board 20 by welding with the wiring part 27. The electrode unit 10 of the electrode patch 100 realizes its electrical connection with the adapter board 20 by plugging its male socket 15 with the female socket 25 welded on the adapter board 20, and the adapter board 20 realizes its electrical connection with the wire 30 by welding its wiring part 27 with the wire 30. The electrode unit 10 of the electrode patch 100 realizes its electrical connection with the wire 30 through the adapter board 20. Preferably, the adapter board 20 is a flexible printed circuit board. Preferably, multiple electrode units 10 are all connected in parallel to the adapter board 20. Even if the electrical connection between a certain electrode unit 10 and the adapter board 20 is interrupted, it will not affect the electrical connection between the remaining electrode units 10 and the adapter board 20.

[0084] Reference Figure 5A And Figure 5B , the adapter board 20 has at least one group of third pads 23 arranged on the body 28 and welded with the corresponding female socket 25, and multiple fourth pads 24 arranged on the opposite side surfaces of the wiring part 27 and welded with the wire 30. The configuration of each group of third pads 23 is the same as the configuration of the second pads 113 of the electrode unit 10. Each group of third pads 23 has multiple third pads 23. One of the multiple third pads 23, i.e., the third pad 23A, is connected to the ground signal, one third pad 23B is connected to the temperature signal, and the remaining third pads 23C are all connected to the AC signal. One group of fourth pads 24 has multiple fourth pads 24. The multiple fourth pads 24 include a fourth pad 24A for transmitting the ground signal, a fourth pad 24C for transmitting the AC signal, and multiple fourth pads 24B for respectively transmitting the corresponding temperature signals. The third pads 23A for transmitting the ground signal in multiple groups of third pads 23 are all connected in parallel to one fourth pad 24A, the multiple third pads 23C for transmitting the AC signal in multiple groups of third pads 23 are all connected in parallel to one fourth pad 24C, and the third pads 23B for transmitting the temperature signal in multiple groups of third pads 23 are all connected to the corresponding fourth pads 24B one by one.

[0085] A plurality of second conductive traces 26 are embedded inside the adapter board 20. A plurality of groups of third pads 23 and fourth pads 24A, 24B, 24C are respectively disposed at opposite ends of the plurality of second conductive traces 26, and electrical connection between the two is achieved through the second conductive traces 26. The plurality of groups of third pads 23 are disposed in a parallel connection state at one end of the plurality of second conductive traces 26. After a plurality of electrode units 10 are respectively inserted into a female seat 25 welded to the plurality of groups of third pads 23 through their respective male seats 15, the plurality of electrode units 10 can be connected to the adapter board 20 in parallel. Furthermore, signal transmission between each electrode unit 10 and the adapter board 20 is independent and does not affect each other. Even if one of the electrode units 10 is damaged, it will not affect the signal transmission between the remaining electrode units 10 and the adapter board 20, ensuring the normal operation of the remaining electrode units 10 without the need to replace or scrap the entire electrode patch 100.

[0086] The multiple second conductive traces 26 include a second ground wire 26A for transmitting a ground signal, a second AC line 26C for transmitting an AC signal, and multiple second signal lines 26B for respectively transmitting corresponding temperature signals. The second AC line 26C transmits the AC signal, is arranged in a dendritic wiring pattern, and is electrically connected to one third pad 23C for connecting the AC signal in each group of third pads 23 and one fourth pad 24C for connecting the AC signal in the fourth pads 24, which can make each electrode unit 10 assembled with the socket 25 corresponding to the respective third pad 23 in an equipotential state, ensuring the stability of the AC signal of the electrode patch 100. One third pad 23C for connecting the AC signal in each group of third pads 23 is connected to the second AC line 26C in a parallel manner, that is, the on / off of the AC signal of each electrode unit 10 assembled with the socket 25 corresponding to the respective third pad 23 does not affect each other. Even during use, if an electrode unit 10 is damaged, it does not affect other electrode units 10 from continuing to apply an alternating electric field to the tumor site of the patient for tumor electric field therapy. The second ground wire 26A transmits the ground signal, is arranged in a dendritic wiring pattern, and is electrically connected to one third pad 23A for connecting the ground signal in each group of third pads 23 and one fourth pad 24A for connecting the ground signal in the fourth pads 24. One third pad 23A for connecting the ground signal in each group of third pads 23 is connected to the second ground wire 26A in a parallel manner, that is, the on / off of the ground signal of each electrode unit 10 assembled with the socket 25 corresponding to the respective third pad 23 does not affect each other. The multiple second signal lines 26B respectively transmit corresponding temperature signals, and are electrically connected in one-to-one correspondence with one third pad 23B for connecting the temperature signal in the corresponding group of third pads 23 and the corresponding one fourth pad 24B for connecting the temperature signal in the fourth pads 24 of this group. Through the above connection relationship between the third pads 23, the fourth pads 24 and the multiple second conductive traces 26, at least one group of third pads 23 is connected in parallel to realize that at least one electrode unit 10 is connected in parallel to the adapter board 20, and the on / off of the AC signal, the ground signal and the temperature signal of each electrode unit 10 do not affect each other.

[0087] That is, multiple third pads 23C are connected to the second AC line 26C in parallel. Multiple third pads 23A are also connected to the second ground wire 26A in parallel. Multiple third pads 23B are respectively connected to their corresponding signal lines 26B, and are connected to their corresponding fourth pads 24B through their corresponding signal lines 26B. Each female socket 25 is arranged on the adapter board 20 in parallel by welding with the corresponding group of third pads 23. After each electrode unit 10 is plugged into the corresponding female socket 25 through its corresponding male socket 15, each electrode unit 10 can be connected to the adapter board 20 in parallel, so that the signal on / off between each electrode unit 10 and the adapter board 20 does not affect each other. Even if one of the electrode units 10 is damaged or the electrical connection between it and the adapter board 20 is disconnected, it will not affect the electrical connection and signal transmission between the remaining electrode units 10 and the adapter board 20.

[0088] Multiple third pads 23A for transmitting ground signals and a fourth pad 24A for transmitting ground signals are respectively arranged at opposite ends of a second ground wire 26A, and the corresponding electrical connection between the third pad 23A and the fourth pad 24A is realized through this second ground wire 26A. And multiple third pads 23A are arranged in parallel at one end of the second ground wire 26A, so that after multiple electrode units 10 are plugged into the corresponding female sockets 25 of the adapter board 20, the ground signal transmission of each electrode unit 10 is independent and does not affect each other. One end of each second signal line 26B for transmitting temperature signals is connected to a third pad 23B for transmitting temperature signals, and the other end is connected to a fourth pad 24B for transmitting temperature signals and corresponding to the third pad 23B, so as to respectively transmit the temperature signals collected by the temperature sensors 14 of each electrode unit 10. After each electrode unit 10 is plugged into the adapter board 20, the temperature signal transmission between each electrode unit 10 can be independent and does not affect each other.

[0089] Multiple third pads 23C for transmitting AC signals and a fourth pad 24C for transmitting AC signals are respectively arranged at opposite ends of a second AC line 26C, and the corresponding electrical connection between the third pad 23C and the fourth pad 24C is realized through this second AC line 26C. And multiple third pads 23C are all arranged in parallel at one end of the second AC line 26C. The second AC line 26C for transmitting AC signals is arranged in a dendritic pattern. One end of it is electrically connected to one of the third pads 23C in each group of third pads 23, and the other end is electrically connected to one of the fourth pads 24 in multiple fourth pads 24. After each electrode unit 10 is plugged into the corresponding female socket 25 of the adapter board 20 through its corresponding male socket 15, the AC signal transmission of each electrode unit 10 can be independent and does not affect each other.

[0090] In this embodiment, the number of the fourth pads 24 is greater than the number of the second conductive traces 26. The fourth pads 24A, 24B, and 24C that are electrically connected to the corresponding second conductive traces 26 are all conductive pads. The fourth pads 24 further include a dummy pad 24D that is disposed in a disconnected state from the second conductive trace 26, which can enhance the welding firmness between the flexible adapter board 20 and the wire 30.

[0091] In this embodiment, the multiple second conductive traces 26 embedded inside the adapter board 20 are distributed in two wiring layers to avoid mutual interference among the second conductive traces 26. In this embodiment, the second AC lines 26C are distributed in one layer, and the second ground lines 26A and the second signal lines 26B are both distributed in two wiring layers to avoid the second AC lines 26C. In other embodiments, the multiple second conductive traces 26 embedded inside the adapter board 20 are distributed in three or more wiring layers, which can improve the flexibility of the wiring of the multiple second conductive traces 26.

[0092] As Figure 4 、 Figure 5A and Figure 5B shown, in this embodiment, the adapter board 20 has a plurality of female sockets 25 that are respectively welded to the corresponding groups of third pads 23. The multiple female sockets 25 are respectively and spacedly welded on the body 28. The body 28 of the adapter board 20 further has a main trunk 21 and at least one branch 22. The wiring portion 27 is located at one end of the main trunk 21 of the body 28. The second conductive traces 26 of the adapter board 20 are embedded in the main trunk 21 and the branch 22 of the body 28. The multiple female sockets 25 are respectively and spacedly welded on a main trunk 21 and at least one branch 22, so that the multiple electrode units 10 are spacedly grouped on the adapter board 20 through the plug-in cooperation between the female sockets 25 and the male sockets 15 of the electrode units 10, and at the same time, electrical connection between the multiple electrode units 10 and the adapter board 20 is realized.

[0093] In this embodiment, the main trunk 21 of the body 28 of the adapter board 20 is provided with at least one through-shaped hollow hole 211. The hollow hole 211 of the body 28 of the adapter board 20 can allow the ceramic transducer 12 of the corresponding electrode unit 10 to pass through, so that the ceramic transducer 12 of the corresponding electrode unit 10 can be exposed to the side of the adapter board 20 away from the female socket 25, and further, the ceramic transducer 12 of the corresponding electrode unit 10 can pass through the adapter board 20 and be disposed on the human skin surface.

[0094] In this embodiment, the adapter board 20 has one main trunk 21 and four branches 22 extending from the main trunk 21 to both sides. Two branches 22 are respectively arranged on both sides of the main trunk 21. The branches 22 on different sides of the main trunk 21 are arranged in pairs in an aligned manner. There is a gap 221 between two adjacent branches 22 on the same side of the main trunk 21 that can allow the ceramic transducer 12 of the corresponding electrode unit 10 to pass through, so that the ceramic transducer 12 of the corresponding electrode unit 10 can be exposed to the side of the adapter board 20 away from the female socket 25, and further the ceramic transducer 12 of the corresponding electrode unit 10 can pass through the adapter board 20 and be arranged on the human skin surface.

[0095] In this embodiment, 13 female sockets 25 are provided on the adapter board 20, and the 13 female sockets 25 are respectively arranged on one main trunk 21 and four branches 22 of the main body 28. Three female sockets are provided on the main trunk 21, two female sockets are respectively provided on the two branches 22 close to the wiring part 27, and three female sockets are respectively provided on the other two branches 22. Two hollow holes 211 are provided through the main trunk 21 to respectively accommodate the ceramic transducers 12 of the corresponding one electrode unit 10. The three female sockets 25 on the main trunk 21, the two hollow holes 211 provided on the main trunk 21, and the wiring part 27 are all arranged in an axisymmetric shape, and the straight lines where their axes of symmetry are located coincide. As Figure 4 shown, the three female sockets 25 on the main trunk 21 and the two hollow holes 211 provided on the main trunk 21 are arranged in a longitudinally aligned manner. Two of the three female sockets 25 on the main trunk 21 are arranged on the same side of one hollow hole 211 away from the wiring part 27, and the other is arranged at the position of the main trunk 21 between the two hollow holes 211.

[0096] Two female sockets 25 provided on the branch 22 near the wiring part 27 are disposed on the corresponding branch 22 in a substantially "L" shape. Three female sockets 25 provided on the branch 22 far from the wiring part 27 are disposed on the corresponding branch 22 in a substantially "Π" shape with one end open, and the opening of the "Π" formed by the three female sockets 25 faces the main trunk 21. A plurality of female sockets 25 provided on the branch 22 are symmetrically arranged along the longitudinal symmetry axis of the main trunk 21. Two of the five female sockets 25 on the two branches 22 on the same side of the main trunk 21 are longitudinally aligned and respectively provided at the ends of the corresponding branches 22, and the remaining three are longitudinally aligned and respectively provided at positions of the corresponding branches 22 close to the main trunk 21. Three female sockets 25 provided on the main trunk 21 are longitudinally aligned. Four female sockets 25 on the branches 22 on opposite sides of the main trunk 21 and both close to the wiring part 27 are horizontally aligned in pairs. Specifically, two female sockets 25 respectively provided at the ends of the two branches 22 close to the wiring part 27 are horizontally aligned, and two female sockets 25 respectively provided on the two branches 22 close to the wiring part 27 and close to the main trunk 21 are also horizontally aligned. Two female sockets 25 respectively provided at the ends of the two branches 22 far from the wiring part 27 are horizontally aligned, and two of the four female sockets 25 respectively provided at positions of the two branches 22 far from the wiring part 27 and close to the main trunk 21 are horizontally aligned, and the other two are also horizontally aligned.

[0097] In this embodiment, the female sockets 25 located on the branch 22 are evenly distributed on the edge of the corresponding branch 22, and the female sockets 25 located on the main trunk 21 and the corresponding female sockets 25 located on the branch 22 are horizontally aligned respectively, so as to facilitate the wiring arrangement of the second conductive traces 26 of the adapter board 20, and the female sockets 25 are connected in parallel through the second conductive traces 26 and arranged on the adapter board. Combining Figure 4 and Figure 6B As shown, the electrode units 10 detachably connected to the female sockets 25 at the ends of the respective branches 22 are horizontally grouped and arranged on the adapter board 20, and the electrode units 10 detachably combined with the female sockets 25 other than at the ends of the respective branches 22 are all longitudinally grouped and arranged on the adapter board 20. In other embodiments, since the electrode units 10 are connected to the adapter board 20 in parallel, the on-off of the AC signal, ground signal and temperature signal of each electrode unit 10 does not affect each other, and the number of electrode units 10 detachably combined on the adapter board 20 is less than the number of female sockets 25 on the adapter board 20.

[0098] Combining Figure 4 、 Figure 5A 、 Figure 5B and Figure 8A, one end of the wire 30 is electrically connected to the wiring part 27 of the adapter board 20, and the other end is provided with a plug 32. Preferably, the wire 30 is a Remo female head sheathed wire. The wire 30 has a plurality of wire cores (not shown), and each wire core (not shown) is respectively welded to the corresponding fourth pads 24 on both side surfaces of the wiring part 27. In this embodiment, the number of electrode units 10 of the electrode patch 100 is 13, and the number of wire cores (not shown) of the wire 30 is 16. Accordingly, there are wire cores (not shown) in the wire 30 that are welded to the fourth pads 24A, 24B, and 24C for power conduction and wire cores (not shown) that are welded to the virtual pad 24D without power conduction. A heat shrinkable tube 31 is also provided around the periphery of the welding joint between the wire 30 and the wiring part 27 for sealing and insulating protection of the welding joint between the adapter board 20 and the wire 30, to prevent the welding joint between the adapter board 20 and the wire 30 from breaking, and at the same time, it can also prevent dust and water.

[0099] The wire 30 further includes a shielding mesh wire (not shown) covering the periphery of the plurality of wire cores (not shown). The fourth pad 24 further includes a fourth pad 24E located at the end of the wiring part 27, which can be welded to the shielding mesh wire (shown) of the wire 30 to shield the wire 30 and prevent external signals from interfering with the signals transmitted by the plurality of wire cores (not shown) of the wire 30. The fourth pad 24E for shielding and the fourth pad 24A for transmitting the ground signal are both connected to the second ground wire 26A of the second conductive trace 26.

[0100] As Figure 8A , Figure 8B shown, a patch cord 33 can also be plugged into the plug 32 of the wire 30. It can be plugged into an electric field generator (not shown) through the patch cord 33 to achieve electrical connection with the electric field generator (not shown), or it can be plugged into an adapter (not shown) through the patch cord 33, and then plugged into the electric field generator (not shown) through the adapter (not shown) to achieve electrical connection with the electric field generator (not shown). The patch cord 33 is detachably connected to the wire 30. It can not only increase or decrease the distance between the wire 30 and the electric field generator (not shown) or the adapter (not shown) as needed, but also when the electrode patch 100 is scrapped and needs to be replaced, only the wire 30 welded to the adapter board 20 needs to be scrapped, without having to scrap the patch cord 33, which can reduce costs and avoid unnecessary waste. The number of wire cores (not shown) of the patch cord 33 is the same as that of the wire 30 and corresponds one by one. The patch cord 33 is a Remo double male head sheathed wire.

[0101] The backing 40 is provided in a sheet shape and has at least one through hole 41 corresponding to the electrode unit 10 and provided in a penetrating manner. The through hole 41 of the backing 40 can allow the corresponding part of the electrode unit 10 to expose the surface on the side away from the adapter board 20, which is beneficial to dissipate the heat generated during tumor electric field therapy by the electrode patch 100. In this embodiment, the support plate 13 of the electrode unit 10 passes through the through hole 41 of the backing 40 and exposes the surface on the side of the backing 40 away from the adapter board 20. The size of the through hole 41 of the backing 40 is slightly larger than the size of the support plate 13.

[0102] The support member 50 is provided in a sheet shape and has a plurality of through holes 51 provided in a penetrating manner. The plurality of through holes 51 of the support member 50 include a plurality of first through holes 51A distributed corresponding to the respective electrode units 10 and two second through holes 51B provided in a strip shape and located between the plurality of first through holes 51A. Each first through hole 51A houses the ceramic transducer 12 of the corresponding electrode unit 10. The surface of the support member 50 on the side close to the patient's body surface is flush with the surface of the ceramic transducer 12 on the side close to the patient's body surface, so that the adhesive member 60 can be flatly covered on the support member 50 and the ceramic transducer 12, improving the comfort of the electrode patch 100 during application. The two second through holes 51B respectively correspond to the parts where the branches 22 extend laterally from the main body 21 of the adapter board 20, so that part of the heat of the electrode patch 100 can be transferred from the adapter board 20 through the backing 40 to the external environment for heat dissipation. The two second through holes 51B are both long holes. The size of each first through hole 51A is slightly larger than the size of the end of the electrode unit 10 where the ceramic transducer 12 is welded. Preferably, the support member 50 is a foam.

[0103] There are multiple adhesive members 60. Each adhesive member 60 is generally provided in a strip-like sheet shape, has double-sided adhesiveness, one side of which is adhered to the corresponding parts of the support member 50 and the ceramic transducer 12, and the other side is adhered to the patient's body surface. Preferably, the adhesive member 60 is a conductive hydrogel. Each adhesive member 60 covers the ceramic transducer 12 of at least one electrode unit 10. In this embodiment, there are 5 adhesive members 60, and each covers the ceramic transducer 12 of 2 or 3 electrode units 10. There are 3 adhesive members 60 arranged horizontally in parallel and each covers the ceramic transducer 12 of 3 electrode units 10; there are 2 adhesive members 60 arranged vertically in parallel and each covers the ceramic transducer 12 of 2 electrode units 10. The 2 adhesive members 60 arranged vertically in parallel are distributed on both sides of the 3 adhesive members 60 arranged horizontally in parallel.

[0104] The electrode patch 100 may further include at least one release paper 70. The release paper 70 is located on the side of the adhesive member 60 away from the backing 40 and covers the corresponding parts of the adhesive member 60 and the backing 40 to protect the adhesive member 60 and the backing 40 from being soiled. In this embodiment, the electrode patch 100 has two release papers 70. The two release papers 70 jointly cover the adhesive member 60 and the backing 40.

[0105] FIGS. 9 to 11 show the electrode patch 100' according to the second embodiment of the present invention. The electrode patch 100' of this embodiment includes an electrode unit 10', an adapter board 20' detachably connected to the electrode unit 10', a wire 30' electrically connected to the adapter board 20', a backing 40' adhered to the corresponding parts of the electrode unit 10' and the adapter board 20', a support member 50' surrounding the corresponding part of the electrode unit 10' and adhered to the backing 40', and an adhesive member 60' covering the support member 50' and the corresponding part of the electrode unit 10' and fitting to the body surface skin corresponding to the patient's tumor site. The electrode patch 100' is attached to the body surface corresponding to the patient's tumor site through the backing 40', and an alternating electric field is applied to the patient's tumor site through one electrode unit 10' detachably connected to the adapter board 20' to interfere with or prevent the mitosis of the patient's tumor cells, thereby achieving the purpose of treating tumors.

[0106] Compared with the electrode patch 100 of the first embodiment, the electrode patch 100' of this embodiment also includes an adapter board 20', one electrode unit 10' detachably assembled on the adapter board 20', a wire 30' welded to the adapter board 20, a backing 40' adhered to the corresponding parts of the electrode unit 10' and the adapter board 20', a support member 50' surrounding the corresponding part of the electrode unit 10' and adhered to the backing 40', and an adhesive member 60' covering the support member 50' and the corresponding part of the electrode unit 10' and fitting to the body surface skin corresponding to the patient's tumor site. The electrode unit 10' of the electrode patch 100' of this embodiment has the same structure as the electrode unit 10 of the electrode patch 100 of the first embodiment, and also includes insulating plates 13' and ceramic transducer chips 12' on opposite sides of the flexible plate substrate 11', and male connectors 15' at opposite ends on the same side of the flexible plate substrate 11' as the ceramic transducer chips 12'. The difference between the electrode patch 100' of this embodiment and the electrode patch 100 of the first embodiment is that the electrode patch 100' only includes one electrode unit 10' detachably plugged into the adapter board 20', and the shapes of the adapter board 20' and the backing 40' are different due to the different numbers of the plugged electrode units 10'.

[0107] Specifically refer to Figures 9A to 11BAs shown, the adapter board 20' also includes a body 28' plugged into the electrode unit 10', a female socket 25' provided on the body 28', and a wiring portion 27' laterally extending from the body 28'. The male socket 15' of the electrode unit 10' is plugged into the female socket 25' to achieve electrical connection between the electrode unit 10' and the adapter board 20'. The wiring portion 27' is welded to the wire 30' to achieve electrical connection between the adapter board 20' and the wire 30'. The body 28' has only one main trunk 21'. The female socket 25' is provided on the main trunk 21' and is located at opposite ends of the main trunk 21' from the wiring portion 27'. There is only one set of third pads 23' welded to the female socket 25' on the main trunk 21'. The third pads 23' include a third pad 23B' for transmitting temperature signals, a third pad 23A' for transmitting ground signals, and multiple third pads 23C' for transmitting alternating current signals. The multiple third pads 23C' are all electrically connected to a transmission AC signal line. In this embodiment, there are six third pads 23', including one third pad 23B' for transmitting temperature signals, one third pad 23A' for transmitting ground signals, and four third pads 23C' for transmitting alternating current signals. There is only one female socket 25'. A plurality of fourth pads 24' for welding to the wire 30' are provided on both side surfaces of the wiring portion 27'. The fourth pads 24' include a fourth pad 24A' for transmitting ground signals, a fourth pad 24B' for transmitting temperature signals, a fourth pad 24C' for transmitting alternating current signals, multiple fourth pads 24D', and a fourth pad 24E' for shielding. The fourth pads 24D' are respectively provided on opposite sides of the wiring portion 27' of the adapter board 20'. In this embodiment, there are seven fourth pads 24D', two of which are provided on the same side of the adapter board 20', and the other five are provided on the other side of the adapter board 20'. The two fourth pads 24D' on the same side are respectively arranged in a manner that separates the three fourth pads 24A', 24B', and 24C' on the same side from each other at one end side of the wiring portion 27'. The fourth pads 24D' can be welded to the corresponding wire cores of the wire 30' to make the welding between the wiring portion 27' and the wire 30' more firm, and to prevent the adapter board 20' from being damaged and unable to transmit signals due to the disconnection of the welding portion between the wiring portion 27' and the wire 30' when the wire 30' is stressed and pulled.

[0108] Three second conductive traces 26' are embedded in the adapter board 20'. None of the fourth pads 24D' are electrically connected to the second conductive traces 26'. The three second conductive traces 26' are respectively a second ground wire 26A', a second signal wire 26B', and a second AC wire 26C'. One end of the second ground wire 26A' is connected to the third pad 23A', and the other end is connected to a fourth pad 24A' for transmitting a ground signal. One end of the second signal wire 26B' is connected to the third pad 23B', and the other end is connected to the fourth pad 24B' for transmitting a temperature signal. One end of the second AC wire 26C' is serially connected to the remaining 4 third pads 23C', and the other end is connected to a fourth pad 24C' for transmitting an alternating current signal. In this embodiment, the number of the fourth pads 24' is more than the number of the fourth pads 24' connected to the second conductive traces 26. There are 5 fourth pads 24' on each side of the wiring part 27'. The fourth pads 24' on one side include the fourth pads 24A', 24B', 24C' respectively electrically connected to the second ground wire 26A', the second signal wire 26B', and the second AC wire 26C' and two fourth pads 24D' not electrically connected to the second ground wire 26A', the second signal wire 26B', and the second AC wire 26C'. The 5 fourth pads 24' on the other side of the wiring part 27' are all fourth pads 24D', and they are not electrically connected to the second conductive traces 26'. The fourth pads 24' electrically connected to the second conductive traces 26' are all conductive pads 24A', 24B', 24C', and the fourth pads 24' not electrically connected to the second conductive traces 26' are all virtual pads 24D'. The 3 conductive pads 24A', 24B', 24C' and the third pads 23A', 23B', 23C' are all located on the same side of the adapter board 20'. The fourth pad 24E' for shielding is also electrically connected to the second ground wire 26A'.

[0109] The wire 30' has 10 wire cores (not shown), among which 3 wire cores (not shown) are respectively welded to the 3 conductive pads 24A', 24B', 24C' among the fourth pads 24' of the wiring part 27' in one-to-one correspondence, and the remaining 7 wire cores (not shown) are respectively welded to the 7 virtual pads 24D' in one-to-one correspondence. One end of the wire 30' away from the wiring part 27' is provided with a plug 32'. The plug 32' can also be connected to an adapter wire 33'. The number of wire cores (not shown) of the adapter wire 33' is the same as that of the wire cores (not shown) of the wire 30' and they correspond one-to-one. The soldering joint between the wire 30' and the wiring part 27' of the adapter board 20' is wrapped with a heat shrinkable sleeve 31'.

[0110] The backsheet 40' is generally arranged in a square sheet shape, and at least two lugs 42' are provided at its edges to facilitate the operator to hold the electrode patch 100' and apply the electrode patch 100' to the corresponding body surface of the patient's tumor site. The side of the electrode unit 10' away from the ceramic transducer 12' is adhered to the backsheet 40'. The backsheet 40' also adheres to the corresponding parts of the adapter plate 20' and the heat shrink tube 31'. The heat shrink tube 31 can also be wrapped around the periphery of the detachable assembly of the male seat 15' and the female seat 25'.

[0111] The support member 50' is generally arranged in a square sheet shape, and a through hole 51' is provided in the middle thereof. The through hole 51' is similar to the first through hole 51A of the embodiment and is used to accommodate the ceramic transducer 12' of the electrode unit 10'. The same as the first embodiment, the support member 50' is generally flush with the surface of the ceramic transducer 12' of the electrode unit 10' away from the backsheet 40'.

[0112] The adhesive member 60' is generally arranged in a square sheet shape and covers the surface of the support member 50' and the ceramic transducer 12' of the electrode unit 10' away from the backsheet 40'. The size of the adhesive member 60' is generally the same as the size of the support member 50'.

[0113] The electrode patches 100, 100' of the tumor electric field treatment instrument (not shown) of the present invention are detachably connected by at least one electrode unit 10, 10' and the adapter plate 20, 20' to realize detachable replacement of the failed electrode unit 10, 10' on the electrode patches 100, 100', or detachable replacement of the failed adapter plate 20, 20' on the electrode patches 100, 100', reduce the loss of the whole electrode patch 100, 100', reduce the yield loss of the electrode patches 100, 100', and avoid scrapping and wasting of the whole electrode patch 100, 100' when one of the electrode unit 10, 10' and the adapter plate 20, 20' is damaged. In addition, the electrode patch 100 of the present application cooperates with a plurality of female seats 25 provided on the adapter plate 20 and the electrode unit 10 that can be inserted into the female seat 25. The appropriate number of electrode units 10 can be freely selected and inserted into the adapter plate 20' according to the size and position of the tumor site, so as to ensure that the coverage area of the electrode patch 100 and the intensity of the applied alternating electric field reach the electric field intensity required for tumor treatment.

[0114] Figure 12 For Figures 1 to 1 the manufacturing method of the electrode patches 100, 100' of the present invention shown in 1, which includes the following steps:

[0115] S11. Provide an adapter plate 20, 20', the adapter plate 20, 20' having at least one set of third pads 23, 23' and a wiring portion 27, 27';

[0116] S12, providing at least one female socket 25, 25', and welding the female sockets 25, 25' to the corresponding third soldering pads 23, 23' of the adapter plates 20, 20' respectively;

[0117] S13, providing a wire 30, 30', and assembling the wire 30, 30' on the connection parts 27, 27' of the adapter plates 20, 20';

[0118] S14, providing a heat shrinkable tube 31, 31', and covering the heat shrinkable tube 31, 31' at the connection between the adapter plate 20, 20' and the wire 30, 30';

[0119] S15, providing at least one electrode unit 10, 10' detachably connected to the adapter plate 20, 20', and clamping the electrode unit 10, 10' to the female socket 25, 25' on the adapter plate 20, 20';

[0120] S16, providing a backing 40, 40', and gluing the corresponding part of the surface of one side of the adapter plate 20, 20' provided with the female seat 25, 25' after the above steps and the surface of the electrode unit 10, 10' on the same side to the backing 40, 40'.

[0121] In the above step S11, the adapter board 20, 20' further comprises the body 28, 28' of the above first and second embodiments. At least one set of third pads 23, 23' is distributed on the body 28, 28'. The body 28, 28' is connected to the wiring portion 27, 27'.

[0122] In the above step S13, the wires 30, 30' can also be plugged into the adapter wires 33, 33' of the above-mentioned first embodiment and second embodiment.

[0123] The manufacturing method of the electrode patch 100, 100' of the present invention further comprises the following steps:

[0124] S17, providing a support member 50, 50', and bonding the support member 50, 50' to the backing 40, 40' so as to surround the corresponding parts of the electrode units 10, 10';

[0125] S18, providing an adhesive member 60, 60', and adhering the adhesive member 60, 60' to the surface of the side of the corresponding part of the support member 50, 50' and the electrode unit 10, 10' away from the backing 40, 40';

[0126] S19, providing a release paper 70, and covering the release paper 70 on the surface of the backing 40, 40' and the adhesive member 60, 60' close to the patient's skin.

[0127] In the above step S17, the support members 50, 50' have at least one through-hole 51, 51' provided therethrough to receive corresponding parts of the corresponding electrode units 10, 10'.

[0128] Refer Figure 13 , a method for manufacturing the electrode units 10, 10' of the electrode patches 100, 100' of the present invention includes the following steps:

[0129] S21. Provide a flexible board substrate 11. One end of the flexible board substrate 11 has a plurality of conductive pads 111 arranged at intervals and two first pads 112 located within the area surrounded by the plurality of conductive pads 111, and the other end has a plurality of second pads 113;

[0130] S22. Provide a support board 13, and group the support board 13 on the flexible board substrate 11 in a one-to-one correspondence with the plurality of conductive pads 111. The support board 13 and the conductive pads 111 are respectively located on opposite sides of the flexible board substrate 11;

[0131] S23. Provide a temperature sensor 14, and weld the temperature sensor 14 on the two first pads 112;

[0132] S24. Provide a ceramic transducer 12 having an opening 121, and weld the ceramic transducer 12 on the plurality of conductive pads 111 in such a way that the corresponding temperature sensor is received within the opening thereof. The temperature sensor 14 is received within the opening 121 of the ceramic transducer 12;

[0133] S25. Provide a male socket 15, and weld the male socket 15 on the plurality of second pads 113.

[0134] The conductive pads 111, the first pads 112, and the second pads 113 in step S21 are all provided on the same side surface of the flexible board substrate 11. The conductive pads 111 and the second pads 113 are respectively located at opposite ends of the flexible board substrate 11.

[0135] The above is only the preferred embodiment of the present application, and it is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included within the scope of protection of the present application.

Claims

1. An electrode patch for treating tumors by means of electric fields, characterized in that, It includes a plurality of electrode units, an adapter board formed by a flexible circuit board, and a backing. The plurality of electrode units and the adapter board are both adhered to the backing, and the electrode units are located between the backing and the adapter board. The electrode unit includes a flexible board substrate and a ceramic transducer. A male socket is provided on the flexible board substrate, and the ceramic transducer and the male socket are respectively located at opposite ends of the flexible board substrate. A plurality of female sockets are provided on the adapter board. The plurality of electrode units are spaced and arranged on the adapter board by plugging their male sockets into the female sockets, and a detachable electrical connection is formed between the electrode units and the adapter board; the adapter board includes a body, the body includes a main trunk and branches, and the main trunk and the branches are both provided with the female sockets. The main trunk is provided with at least one through-shaped hollow hole. When the male socket is plugged into the female socket, the hollow hole allows the ceramic transducer of the corresponding electrode unit to pass through. There is a gap between the two branches. When the male socket is plugged into the female socket, the gap allows the ceramic transducer of the corresponding electrode unit to pass through.

2. The electrode patch according to claim 1, characterized in that, Each of the electrode units includes a support plate respectively provided on both sides of the flexible board substrate with the ceramic transducer. The male socket is provided on the flexible board substrate and is on the same side surface of the flexible board substrate as the ceramic transducer.

3. The electrode patch according to claim 2, characterized in that, The ceramic transducer and the support plate are both located at the same end of the flexible board substrate.

4. The electrode patch according to claim 2, wherein, The electrode unit further includes a temperature sensor provided on the flexible board substrate and on the same side as the ceramic transducer.

5. The electrode patch according to claim 4, wherein, The ceramic transducer has a through-opening, and the temperature sensor is received in the opening of the ceramic transducer.

6. The electrode patch according to claim 1, wherein, The electrode unit and the adapter board are adhered to the backing in a partially overlapping manner, and the male socket and the corresponding female socket are located at the overlapping part.

7. The electrode patch according to claim 1, characterized in that, The adapter board includes a wiring portion connected to the body, and the wiring portion is located at one end of the body.

8. The electrode patch according to claim 7, characterized in that, There is one main trunk.

9. The electrode patch according to claim 8, characterized in that, The hollow hole is correspondingly arranged with the corresponding female socket.

10. The electrode patch according to claim 9, wherein When the electrode unit is grouped on the adapter board, the ceramic transducer of the electrode unit exposes to the side of the adapter board away from the female socket.

11. The electrode patch according to claim 8, wherein, There are a plurality of branches, and the plurality of branches are located on both sides of the main trunk.

12. The electrode patch according to claim 11, wherein, There is a gap between two adjacent branches on the same side of the main trunk that allows the ceramic transducer of the corresponding electrode unit to pass through. When the ceramic transducer of the electrode unit passes through the gap, it exposes to the side of the adapter board away from the female socket.

13. The electrode patch according to claim 12, wherein The electrode patch further includes a wire electrically connected to the wiring portion of the adapter board. One end of the wire is electrically connected to the wiring portion of the adapter board, and the other end is provided with a plug.

14. The electrode patch according to claim 13, characterized in that, A heat shrinkable tube is also coated around the connection part of the wire and the wiring portion.

15. The electrode patch according to claim 13, characterized in that, The plug of the wire is also detachably plugged into a patch cord.

16. The electrode patch according to claim 1, wherein, The backing is in a sheet shape and has at least one through-shaped through-hole corresponding to the electrode unit. The through-hole of the backing allows the corresponding part of the electrode unit to expose to the side surface of the backing away from the adapter board.

17. The electrode patch according to claim 16, characterized in that, The electrode patch further includes a support member disposed around a corresponding portion of the electrode unit and adhered to the backing, and an adhesive member covering the support member and the corresponding portion of the electrode unit and conforming to the body surface skin corresponding to the patient's tumor site.

18. The electrode patch according to claim 17, wherein At least one of the support members has a perforation formed therethrough.

19. The electrode patch according to claim 18, wherein The perforation includes a first perforation corresponding to the corresponding electrode unit and receiving a corresponding portion of the corresponding electrode unit.

20. The electrode patch according to claim 19, wherein, The perforation further includes a second perforation located between a plurality of the first perforations and opposite to the adapter plate.

21. The electrode patch according to claim 17, characterized in that, The electrode patch further includes at least one release paper located on a side of the adhesive member facing away from the backing and covering the adhesive member and the backing.

22. A manufacturing method of an electrode patch according to any one of claims 1 to 21, characterized in that, Including the following steps: S11. Provide an adapter plate having at least one set of third pads and a wiring portion; S12. Provide a plurality of female sockets and solder the female sockets to the corresponding third pads on the adapter plate respectively; S13. Provide a wire and arrange the wire group on the wiring portion of the adapter plate; S14. Provide a heat shrinkable sleeve and cover the connection between the adapter plate and the wire with the heat shrinkable sleeve; S15. Provide a plurality of electrode units, each electrode unit being provided with a male socket, and the male sockets of each electrode unit are inserted and cooperated with the female sockets on the adapter plate to electrically connect the plurality of electrode units in parallel to the adapter plate; S16. Provide a backing and bond a corresponding portion of a surface of the adapter plate provided with the female sockets and a surface of the electrode unit on the same side to the backing.

23. The manufacturing method of the electrode patch according to claim 22, characterized in that, After the step S16, the following steps are further included: S17. Provide a support member and bond the support member around a corresponding portion of the electrode unit to the backing; S18. Provide an adhesive member and adhere the adhesive member to a surface of the support member and the corresponding portion of the electrode unit away from the backing; S19. Provide a release paper and cover the surface of the backing and the adhesive member close to the patient's skin with the release paper.

24. The manufacturing method of the electrode patch according to claim 22, wherein, The manufacturing method of the electrode unit includes the following steps: S21. Provide a flexible board substrate, one end of the flexible board substrate having a plurality of spaced conductive pads and two first pads located within a region surrounded by the plurality of conductive pads, and the other end having a plurality of second pads, and the male socket is soldered to the plurality of second pads; S22. Provide a support board and respectively arrange the support board on the flexible board substrate in a one-to-one correspondence with the plurality of conductive pads, the support board and the conductive pads being located on opposite sides of the flexible board substrate respectively; S23. Provide a temperature sensor and solder the temperature sensor to the two first pads; S24. Provide a ceramic transducer having an opening and solder the ceramic transducer to the plurality of conductive pads in such a way that the temperature sensor is received within the opening thereof.

25. A tumor electric field treatment apparatus, characterized in that, Including an electric field generator and at least a pair of electrode patches as described in any one of claims 1 to 21 electrically connected to the electric field generator.

26. The tumor electro-field therapy apparatus according to claim 25, wherein, It further includes an adapter connected electrically between the electrode patch and the electric field generator.

Images