Tumor Therapeutic Fields System

Abstract

The present application provides a tumor electric field therapy system, including an electric field generator and a plurality of electrode patches arranged in pairs, wherein the plurality of pairs of electrode patches include a pair of first electrode patches and a pair of second electrode patches, wherein the first electrode patches and the second electrode patches are each provided with a plurality of electrode units, wherein the plurality of electrode units in the same row of the first electrode patch have centers on the same arc line, and the plurality of electrode units in the same row of the second electrode patch have centers on the same horizontal line. The tumor electric field therapy system of the present application includes a first electrode patch and a second electrode patch, wherein the electrode units of the first electrode patch and the second electrode patch are distributed in different ways, wherein the current density mean of the first electrode patch is relatively low, and the current density uniformity of the second electrode patch is better, and corresponding electrode patches can be applied to different areas of the patient.

Description

Technical Field

[0001] The present application relates to a tumor electric field therapy system. Background Art

[0002] Medium-frequency alternating electric field therapy has been shown to be an effective method for tumor treatment, capable of disrupting the mitotic process of cancer cells and inducing apoptosis, making it suitable for treating tumors. A tumor electric field therapy system typically includes an electric field generator, an adapter, and multiple pairs of electrode patches. The electric field generator generates an alternating electrical signal, which is transmitted to the electrode patches via the adapter. The electrode patches are applied in pairs to opposite sides of the patient's skin, and an alternating current signal is applied between each pair of electrode patches to non-invasively apply the tumor treatment electric field to the target area.

[0003] The electrode patch is equipped with several electrode units. When electric field therapy is performed, each electrode unit transfers heat outward. The system monitors the temperature of each electrode unit in real time. When the temperature of any electrode unit reaches a threshold, the system reduces the electric field strength to reduce the temperature of the corresponding electrode unit and avoid low-temperature burns to the patient. Studies have found that due to the influence of the edge effect, the electrode units at the edge of the electrode patch are more likely to heat up. The so-called edge effect refers to the phenomenon of a sudden increase in local current density caused by the superposition of electromagnetic field vectors at the edge of the electrode patch. The increase in local current density will cause the heat generated in the corresponding part of the electrode patch to increase. The local accumulation of heat will cause the temperature of the corresponding electrode unit to exceed the threshold, and the system needs to reduce the applied electric field strength. The uneven distribution of heat on the entire electrode patch will cause the output energy of the entire electrode patch to decrease due to the temperature of a single point exceeding the threshold, resulting in poor treatment effect.

[0004] Therefore, there is a need to improve the existing tumor electric field therapy system and its electrode patch to overcome the problems described in the background technology. Summary of the Invention

[0005] The present application provides a tumor electric field therapy system, which applies electrode patches with different performance to different areas, thereby improving the uniformity of the overall current density of the electrode array and the effectiveness of electric field transmission.

[0006] Specifically, the present application is implemented through the following technical solution: a tumor electric field treatment system, including an electric field generator and several electrode patches arranged in pairs, the several pairs of electrode patches including a pair of first electrode patches and a pair of second electrode patches, the first electrode patches and the second electrode patches are each provided with several electrode units, and the several electrode units are arranged in multiple rows and columns, wherein the centers of the several electrode units located in the same row of the first electrode patch are on the same arc line, and the centers of the several electrode units located in the same row of the second electrode patch are on the same horizontal line.

[0007] Furthermore, the first electrode patch and the second electrode patch are provided with a plurality of electrode units of the same number, and the plurality of electrode units of the first electrode patch and the second electrode patch are symmetrically arranged along a horizontal center line and a vertical center line respectively; in the first electrode patch, the two ends of the arc where the electrode units located on the upper side of the horizontal center line are located are arranged in an upward shape, and the two ends of the arc where the electrode units located on the lower side of the horizontal center line are located are arranged in a downward shape.

[0008] Furthermore, the first electrode patch and the second electrode patch each include twenty electrode units distributed in four rows and six columns, and two adjacent electrode units and the connecting portion provided between the two electrode units constitute an electrode unit group, wherein the first row and the fourth row are respectively provided with two electrode unit groups, and the third row and the fourth row are respectively provided with three electrode unit groups, and the electrode units are provided with a dielectric layer, and the dielectric layer of the two electrode units in the electrode unit group also covers the connecting portion between the two electrode units and is continuously arranged.

[0009] Furthermore, in the first electrode patch, the electrode unit group located between the second row and the third row is arranged horizontally, and the other electrode unit groups are arranged inclinedly, and the angle between the line connecting the centers of the two electrode units of the inclined electrode unit group and the horizontal line is 8°-12°.

[0010] Furthermore, the diameter of the electrode unit is 18 mm to 22 mm, and the center distance between two electrode units in the electrode unit group is 32 mm to 35 mm.

[0011] Furthermore, the arcs where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the first electrode patch are located are H1, H2, H3 and H4 respectively, wherein the curvature of arc H1 is greater than the curvature of arc H2, and the curvature of arc H4 is greater than the curvature of arc H3.

[0012] Furthermore, the central angle of the arc segment occupied by the electrode unit group on the arc H1 is 11°-21°.

[0013] Furthermore, the central angle corresponding to the arc segment occupied by the corresponding electrode unit group on the arc H2 is 7°-11°.

[0014] Furthermore, the horizontal lines where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the second electrode patch are located are L1, L2, L3 and L4 respectively, and the vertical distance between adjacent horizontal lines is greater than the vertical distance between two of the electrode units in the first electrode patch that are located in the second column and in the first and second rows respectively.

[0015] Furthermore, the horizontal distance of the gap between the two electrode unit groups in the first row of the first electrode patch is greater than the horizontal distance of the gap between the two electrode unit groups in the second row of the first electrode patch; the horizontal distance of the gap between the two electrode unit groups in the same row of the second electrode patch is greater than the horizontal distance of the gap between the two electrode unit groups in the first row of the first electrode patch.

[0016] The tumor electric field therapy system of the present application includes a first electrode patch and a second electrode patch. The first electrode patch and the second electrode patch have the same number of electrode units but different distribution methods. The first electrode patch has a lower average current density, and the second electrode patch has better current density uniformity. Corresponding electrode patches can be applied to different areas of the patient to pursue the uniformity of the overall current density of the electrode array and the high efficiency of electric field transmission.

[0017] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 1 is a framework diagram of a tumor treating field system according to one embodiment of the present application;

[0019] Figure 2 is a plan view of a first electrode patch according to one embodiment of the present application;

[0020] Figure 3 for Figure 2 a plan view of the electrode array of the first electrode patch in FIG;

[0021] Figure 4 for Figure 3 A plan view of the substrate of the electrode array after a front conductive layer is provided;

[0022] Figure 5 for Figure 3 A plan view of a single electrode unit group of an electrode array;

[0023] Figure 6 For the Figure 3 The cross-sectional view obtained along the AA line;

[0024] Figure 7 for Figure 3 A distribution diagram of electrode unit groups in an electrode array;

[0025] Figure 8 is a plan view of a second electrode patch according to one embodiment of the present application;

[0026] Figure 9 for Figure 8a distribution diagram of electrode unit groups of the electrode array of the second electrode patch;

[0027] Figure 10 A distribution diagram of electrode units in an electrode array in an electrode patch in the prior art;

[0028] Figure 11 for Figure 2 Each electrode unit in the first electrode patch, Figure 8 Each electrode unit in the second electrode patch and Figure 10 A comparison chart of the current density differences of each electrode unit in the electrode patch.

[0029] Description of reference numerals:

[0030] Tumor electric field therapy system 100, electric field generator 10, adapter 20, first electrode patch 30, first backing 31, first electrode array 32, electrode unit group C, C1-C10, electrode unit 320, temperature sensor 321, connecting portion 322, boundary line 3221, wiring portion 323, gold finger 3231, substrate 341, main body 3411, connecting bar 3412, conductive sheet 342, opening 3421, pad 343, dielectric layer 344, insulating layer 345, alloy layer 346, first adhesive 33, second electrode patch 40, second electrode array 42, electrode unit 420. DETAILED DESCRIPTION

[0031] Exemplary embodiments are described in detail herein, with examples illustrated in the accompanying drawings. When the following description refers to the drawings, identical numerals in different figures represent identical or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all embodiments consistent with the present application. Rather, they are merely examples of devices, systems, apparatus, and methods consistent with certain aspects of the present application.

[0032] refer to Figure 1 As shown, the tumor electric field therapy system 100 includes an electric field generator 10, an adapter 20, and a plurality of electrode patches 30, 40 arranged in pairs. The adapter 20 electrically connects the electric field generator 10 and each electrode patch. The electric field generator 10 generates an alternating current signal that meets the treatment requirements. The adapter 20 receives the alternating current signal output from the electric field generator 10 and transmits the alternating current signal to the electrode patches 30, 40. The electrode patches 30, 40 are attached to the surface of the patient's body corresponding to the tumor area, and the alternating current signal is applied to the patient's tumor area for tumor electric field therapy. The present application provides a first electrode patch 30 (see Figure 2 ) and the second electrode patch 40 (see Figure 8 ) Two similar electrode patches, the structure of the first electrode patch 30 is first described below.

[0033] refer to Figure 2 and Figure 3 As shown, the first electrode patch 30 comprises a first backing 31, a first electrode array 32 attached to the front of the first backing 31, and multiple first adhesive members 33 attached to the front of the first electrode array 32. The front surfaces of the first backing 31, the first electrode array 32, and the first adhesive members 33 all face the patient's skin. The first electrode array 32 includes twenty spaced-apart electrode units 320 and eight temperature sensors 321 selectively located on eight of these electrode units 320. The electrode units 320 apply alternating current (AC) signals to the patient. The temperature sensors 321 provide feedback on the temperature at the site of contact of the corresponding electrode units 320, preventing burns to the patient's skin caused by heat generated by the electrode units 320 during AC signal application. The first adhesive member 33 is a sheet-like structure that covers each electrode unit 320. During use, the front surface is attached to the patient's tumor-related area. The first adhesive member 33 is composed of a conductive hydrogel, which enhances the comfort of the electrode units 320 against the patient's skin and serves as a conductive medium for the AC signals passing through the electrode units 320 to be applied to the patient's tumor.

[0034] The first electrode array 32 includes a connecting portion 322 connecting two adjacent electrode units 320 and a wiring portion 323 extending outward from one of the connecting portions 322. A gold finger 3231 is provided on the wiring portion 323. The wiring portion 323 is welded or detachably connected to a wire (not shown). The wire (not shown) is used to electrically connect the first electrode patch 30 to the adapter 20 to receive the alternating current signal from the electric field generator 10 and transmit the temperature detection signal of each temperature sensor 321 to the electric field generator 10.

[0035] The twenty electrode units 320 are arranged in an array of four rows and six columns. The first and fourth rows each have four electrode units 320, and the second and third rows each have six electrode units 320. The six electrode units 320 in each of the second and third rows correspond one to another and are roughly arranged in six columns. The four electrode units 320 in each of the first and fourth rows are respectively located in the middle four columns. The twenty electrode units 320 are numbered 1-20 from left to right and from top to bottom. The multiple electrode units 320 in the same row are not distributed along a horizontal line, but are distributed roughly along an arc. The electrode units 320 in the first and second rows are distributed on the arcs that are upturned at both ends, and the electrode units 320 in the third and fourth rows are distributed on the arcs that are pressed down at both ends. This shape design makes the first electrode array 32 more suitable for application to areas with large undulations on the skin surface and prone to large deformation, such as the armpits and the left and right sides of the human body. This can improve the applicability of the first electrode patch 30 and avoid wrinkles during application.

[0036] In each row of the first electrode array 32, two adjacent electrode units 320 from left to right and the connecting portion 322 between the two electrode units 320 constitute an electrode unit group C. The twenty electrode units 320 constitute ten electrode unit groups C in total. Figure 3 As shown, from left to right and from top to bottom, there are: electrode unit groups C1-C10. The shape of a single electrode unit group C is arranged in a dumbbell shape. There are ten first adhesive members 33 in total. The shape of the first adhesive members 33 is roughly the same as that of a single electrode unit group C and is also arranged in a dumbbell shape. Its size is slightly larger than that of the electrode unit group C, and it covers each electrode unit group C accordingly.

[0037] Combine Figure 4 and Figure 6 As shown, the first electrode array 32 includes a flexible substrate 341 in a sheet-like configuration. The substrate 341 serves as a supporting layer. Each electrode unit 320, each connecting portion 322, and each wiring portion 323 are further configured by further configuring other structures on the front and / or bottom surfaces of the corresponding portions of the substrate 341. The portion of the substrate 341 corresponding to each electrode unit 320 is a main body 3411, and the portion of the substrate 341 corresponding to each connecting portion 322 and wiring portion 323 is a connecting bar 3412. The main body 3411 is in the shape of a circular sheet, and the electrode units 320 are provided with a conductive sheet 342 on the main body 3411. The conductive sheet 342 is in the shape of a ring, and a through-hole 3421 is provided at the center. In other embodiments, the main body 3411 can also be configured in a triangular, polygonal, elliptical, or other shape, and the conductive sheet 342 is configured to follow the shape of the main body 3411. The temperature sensor 321 is placed in the opening 3421 of the conductive sheet 342 of the corresponding electrode unit 320. A pair of pads 343 are provided on the main body 3411 and are welded to the temperature sensor 321. Several conductive traces (not shown) are also provided on the front and back of the substrate 341 to transmit AC signals to each conductive sheet 342, transmit DC signals for temperature measurement to the corresponding pads 343, or connect the corresponding pads 343 to ground. The conductive sheets 342, pads 343, conductive traces (not shown) on the front of the substrate 341, and gold fingers 3231 form the front conductive layer of the first electrode array 32. Figure 4 Conductive traces are omitted (not shown).

[0038] refer to Figure 3 、 Figure 5 and Figure 6As shown, the first electrode array 32 also includes a dielectric layer 344 covering the conductive sheet 342 and electrically connected to the conductive sheet 342. The dielectric layer 344 is laid separately for each electrode unit group C, that is, the dielectric layer 344 between each electrode unit group C is disconnected, and the dielectric layers 344 of the two electrode units 320 in each electrode unit group C are continuously arranged by covering the connecting portion 322 in the corresponding electrode unit group C. The dielectric layer 344 enables the two electrode units 320 in each electrode unit group C to apply an AC signal simultaneously. The shape of the dielectric layer 344 corresponding to each electrode unit group C is consistent with the shape of the electrode unit group C and is arranged in a dumbbell shape. The dielectric layer 344 can completely cover the corresponding conductive sheet 342 to prevent the conductive sheet 342 from directly contacting the human body to generate DC conduction and affect human safety. The edge of the dielectric layer 344 does not exceed the outer contour of the substrate 341 so that the dielectric layer 344 can obtain full support from the substrate 341. The dielectric layer 344 can be made of ceramic material or a polymer dielectric layer with high dielectric constant and low dielectric loss, which is made of a thin film material with non-fixed crystal orientation, high flexibility and high toughness. In this embodiment, the dielectric layer 344 is a polymer dielectric layer.

[0039] Combine Figure 6 As shown, the first electrode array 32 also includes an insulating layer 345. After the front conductive layer (unnumbered) is set and before the dielectric layer 344 is set, the insulating layer 345 is laid on the substrate 341 to form a solder resist layer located on the substrate 341. The insulating layer 345 needs to avoid the solder pad 343 and expose part of the conductive sheet 342 to avoid affecting the electrical connection between the solder pad 343 and the corresponding temperature sensor 321, and the conductive sheet 342 and the corresponding dielectric layer 344. The insulating layer 345 can reduce the heat transfer from the conductive sheet 342 to the dielectric layer 344, thereby playing a heat insulating role. An alloy layer 346 is further selectively laid on the dielectric layer 344, and the first adhesive member 33 is attached to the alloy layer 346. The alloy layer 346 is used as an auxiliary layer to increase the conductive performance between the dielectric layer 344 and the first adhesive member 33.

[0040] refer to Figure 5 As shown, the structure of each electrode unit group C is the same, and as described above, it is arranged in a dumbbell shape. The electrode unit group C is provided with a horizontal axis X1 and a vertical axis Y1, and the electrode unit group C is symmetrically arranged along the horizontal axis X1 and the vertical axis Y1. The center distance between the two electrode units 320 in a single electrode unit group C is 32-35 mm, preferably 33.5 mm, and the radius of a single electrode unit 320 is 9-11 mm, preferably 11 mm; the boundary line 3221 of the connecting portion 322 in the electrode unit group C is two arcs that are symmetrical in the upper and lower parts, and the central angle corresponding to the boundary line 3221 is 40°-44°, preferably 42°. The boundary line 3221 on the upper side is arranged with both ends raised, and the boundary line 3221 on the lower side is arranged with both ends pressed down.

[0041] Figure 7 The distribution diagram of the ten electrode unit groups C of the first electrode patch 30 is shown. It can be understood that only the electrode unit groups C covered with the dielectric layer 344 on the first electrode patch 30 are the effective areas for applying the AC electric field, and other parts basically do not affect the current distribution of the AC electric field. Figure 7 Other parts are omitted. Figure 7 As shown, electrode unit groups C1, C2, C3, C5, C6, C8, C9, and C10 located at the outer edges of the first electrode patch 30 are defined as peripheral electrode unit groups C, and electrode unit groups C4 and C7 located at the center of the first electrode patch 30 are defined as central electrode unit groups C. At least a portion of the perimeter of each peripheral electrode unit group C constitutes the outer boundary M of the entire first electrode array 32, and the portion of the outer boundary M that overlaps with each peripheral electrode unit group C does not exceed 10% of the perimeter of each peripheral electrode unit group C. Furthermore, the outer boundary M has both concave and convex portions. Specifically, its upper and lower edges are concave, and its left and right edges are convex. The region containing these ten electrode unit groups C is defined by a transverse centerline X2 and a vertical centerline Y2. These ten electrode unit groups C are symmetrically arranged along the transverse centerline X2 and the vertical centerline Y2, with the intersection of the transverse centerline X2 and the vertical centerline Y2 defining the center point of the ten electrode unit groups C.

[0042] The electrode unit groups C4 and C7 located at the center of the second row and the third row are arranged horizontally, that is, the horizontal axis X1 of the electrode unit groups C4 and C7 is a horizontal line parallel to the horizontal center line X2, and the other electrode unit groups C are arranged at an angle relative to the horizontal center line X2, so that the center (i.e., the center of the circle) of each electrode unit 320 in each row is located on the same arc line, and the center (i.e., the center of the circle) of each electrode unit 320 in the first row is defined as being located on the arc line H1, the center (i.e., the center of the circle) of each electrode unit 320 in the second row is located on the arc line H2, the center (i.e., the center of the circle) of each electrode unit 320 in the third row is located on the arc line H3, and the center (i.e., the center of the circle) of each electrode unit 320 in the fourth row is located on the arc line H4. Arc H1 and arc H4 are symmetrical along the axis of the horizontal center line X2, and arc H2 and arc H3 are symmetrical along the axis of the horizontal center line X2; arcs H1, H2, H3, and H4 are all symmetrically arranged along the vertical center line Y2; the ends of arcs H1 and H2 are upward, and the ends of arcs H3 and H4 are downward.

[0043] The electrode unit groups C1 and C2 are both arranged in an inclined shape relative to the horizontal center line X2 and symmetrically relative to the vertical center line Y2. The electrode unit group C1 is used as an example for explanation. The angle a1 between the horizontal axis X1 of the electrode unit group C1 and the horizontal line is 8°-12°, preferably 10°; the central angle of the arc segment AB of the electrode unit group C1 at the arc H1 is 11°-21°, preferably 16°. In this embodiment, the radius of the circle in which the arc H1 is located is approximately 192mm, the central angle corresponding to the arc H1 is approximately 36°, and the arc length of the arc H1 is approximately 121mm. In this embodiment, the horizontal line is parallel to the horizontal center line X2.

[0044] Electrode unit groups C3 and C5 are both arranged in an inclined shape relative to the horizontal center line X2 and symmetrical relative to the vertical center line Y2. The electrode unit group C3 is used as an example for explanation. The angle a2 between the horizontal axis X1 of the electrode unit group C3 and the horizontal line is 8°-12°, preferably 10°; the arc segment DE of the electrode unit group C3 on the arc H2 has a corresponding central angle of 7-11°, preferably 9°. In this embodiment, the radius of the circle where the arc H2 is located is approximately 361mm, the central angle corresponding to the arc H2 is approximately 29°, and the arc length of the arc H2 is approximately 183mm. The electrode unit group C4 is arranged horizontally relative to the horizontal center line X2 and is symmetrical along the vertical center line Y2.

[0045] Electrode unit group C9 and electrode unit group C1, electrode unit group C10 and electrode unit group C2 are all symmetrically arranged along the transverse center line X2, electrode unit group C6 and electrode unit group C3, electrode unit group C7 and electrode unit group C4, electrode unit group C8 and electrode unit group C5 are all symmetrically arranged along the transverse center line X2. For relevant setting methods, please refer to the relevant contents of electrode unit groups C1 to C5.

[0046] It can be understood that the arc lengths of arc segment AB and arc segment DE are similar, but the central angle corresponding to arc segment AB is larger than the central angle corresponding to arc segment DE, that is, the curvature of arc H1 is greater than the curvature of arc H2, and arc H1 is more curved. The vertical distances between adjacent arcs H1, H2, H3, and H4 are substantially the same, approximately 33-35 mm. The vertical distance between the center (i.e., the center of the circle) of an electrode unit 320 in electrode unit group C1 that is away from the vertical center line Y2 and the center (i.e., the center of the circle) of an electrode unit 320 in the third electrode unit group C3 that is close to the vertical center line Y2 is d1, that is, the vertical distance between the centers (i.e., the centers of the circles) of the two electrode units 320 located in the first and second rows and both located in the second column is d1, and d1 is approximately 38 mm. The vertical distance between the center (i.e., center of circle) of another electrode unit 320 in electrode unit group C1 near vertical centerline Y2 and the center (i.e., center of circle) of an electrode unit 320 in the adjacent fourth electrode unit group C4 is d2. Specifically, the vertical distance between the centers (i.e., centers) of the two electrode units 320 located in the first and second rows and in the third column is d2, where d2 is smaller than d1 and is approximately 35 mm. The horizontal dimension K1 of the gap between electrode unit groups C1 and C2 is approximately 11.5 mm, and the horizontal dimension K2 of the gap between electrode unit groups C3 and C4 is approximately 7.5 mm.

[0047] refer to Figure 8 and Figure 9 As shown, Figure 8 is the second electrode array 42 of the second electrode patch 40, Figure 9 This is a distribution diagram of the electrode unit group C' of the second electrode array 42. The other component structures of the second electrode patch 40 are similar to those of the first electrode patch 30 and will not be repeated here. The second electrode array 42 also includes twenty electrode units 420 arranged in four rows and six columns, and the twenty electrode units 420 are numbered 1-20 from left to right and from top to bottom. These twenty electrode units 420 constitute ten electrode unit groups C', and the electrode unit groups C'1, C'2, C'3, C'5, C'6, C'8, C'9, and C'10 located at the outer edge of the second electrode patch 40 are also defined as peripheral electrode unit groups C', and the electrode unit groups C'4 and C'7 located at the center of the second electrode patch 40 are central electrode unit groups C'. The hierarchical structure of the second electrode array 42 is also the same as that of the first electrode array 32, and reference may be made to the aforementioned relevant content.

[0048] The second electrode array 42 differs from the first electrode array 32 only in that the ten electrode unit groups C'1-C'10 are all arranged horizontally and symmetrically along the transverse center axis X3 and the vertical center axis Y3. At least a portion of the perimeter of each peripheral electrode unit group C' constitutes the outer boundary N of the corresponding entire electrode array, and the portion of this outer boundary N that overlaps with each peripheral electrode unit group C' does not exceed 10% of the perimeter of the peripheral electrode unit group C'. The centers (i.e., the center of the circle) of the four electrode units 420 in the first row are located on horizontal line L1, the centers (i.e., the center of the circle) of the six electrode units 420 in the second row are located on horizontal line L2, the centers (i.e., the center of the circle) of the six electrode units 420 in the third row are located on horizontal line L3, and the centers (i.e., the center of the circle) of the four electrode units 420 in the fourth row are located on horizontal line L4. The lengths of lines L1 and L4 are approximately 126 mm, and the lengths of lines L2 and L3 are approximately 198 mm. The spacing between adjacent straight lines L1, L2, L3, and L4 is equal, each measuring d3, and is greater than the spacing d1 between adjacent electrode units 420 in the first and second rows, both located in the second column, in the first electrode array 32. The spacing d3 is approximately 44 mm. The horizontal dimension K3 of the gap between adjacent electrode unit groups C' in each row is the same, measuring approximately 16 mm.

[0049] Ginseng Figure 10 , which shows the specific distribution diagram of the twenty electrode units in the electrode array of the electrode patch in the prior art. The spatial arrangement of these electrode units is similar to the arrangement of electrode units 420 in the second electrode array 42. The specific hierarchical structure of these electrode units is similar to that of electrode units 320 and 420 and will not be repeated here. The difference is that in the prior art, these electrode units are independently arranged and independently applied with AC signals.

[0050] In this application, Figure 10 The electrode array in the electrode patch of the prior art shown is used as a comparison electrode array and the first electrode array 32 and the second electrode array 42 are subjected to finite element simulation calculation to analyze the current density and current density uniformity of each electrode unit. Figure 11As shown, the current density of each electrode unit 320 of the first electrode array 32 is lower than that of the corresponding electrode unit 420 of the second electrode array 42, and the current density of the corresponding electrode unit 420 of the second electrode array 42 is lower than that of the corresponding electrode unit of the comparison electrode array. It can be seen that the density of each electrode unit 320 and 420 in the current of the first electrode array 32 and the second electrode array 42 is lower, that is, the grouped arrangement of electrode units can effectively alleviate the generation of edge effects. Further comparing the first electrode array 32 and the second electrode array 42, the current density of each electrode unit in the two electrode arrays is different. Among them, the electrode units 320 (numbered 7 and 8) in the first electrode array 32 have the largest current density reduction, about 27%, compared with the electrode units 420 (numbered 7 and 8) in the second electrode array 42, that is, the average current density of the first electrode array 32 of the first electrode patch 30 is lower.

[0051] However, regarding the current density uniformity of each electrode unit 320 , the standard deviation of the first electrode array 32 is 4.8, and the standard deviation of the second electrode array 42 is 2.9, that is, the second electrode array 42 of the second electrode patch 40 has better current density uniformity.

[0052] Based on the above calculation results, the current density flowing through each electrode unit 320 in the first electrode patch 30 is relatively low, while the current density flowing through each electrode unit 420 in the second electrode patch 40 is more uniform, and the combined use effect is more optimal. Specifically, in areas where the skin is relatively flat, such as the front and back of the human body, and the human body's equivalent resistance in these areas is also relatively uniform, the second electrode patch 40 can be used. In areas where the skin structure is more undulating and prone to large deformation, such as the armpits and the left and right sides of the human body, the first electrode patch 30 can be used to take advantage of the specific changes in the human body's equivalent resistance with the specific body part morphology (the equivalent resistance in the armpit area is larger, and the distance of the edge of the first electrode array 32 becomes shorter and smaller as it extends in both directions). Differentiated settings can be made for the arc lengths and curvatures of the arcs H1, H2, H3, and H4 of the first electrode array 32, catering to the human body's electrical parameters for compensation design. At the same time, the second electrode patch 40 can be used in combination to improve the uniformity of the overall current density and the effectiveness of electric field transmission, thereby maximizing the benefit to the patient.

[0053] The above is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A tumor electric field treatment system, comprising an electric field generator and a plurality of electrode patches arranged in pairs, characterized in that: Several pairs of electrode patches include a pair of first electrode patches and a pair of second electrode patches, the first electrode patches and the second electrode patches each include twenty electrode units distributed in four rows and six columns and symmetrically arranged along a horizontal center line and a vertical center line, two adjacent electrode units and a connecting portion provided between the two electrode units constitute an electrode unit group, wherein the first row and the fourth row are respectively provided with two electrode unit groups, and the third row and the fourth row are respectively provided with three electrode unit groups, the electrode units are provided with a dielectric layer, and the dielectric layer of the two electrode units in the electrode unit group also covers the connecting portion between the two electrode units and is continuously arranged; the centers of the electrode units of the first electrode patch located in the same row are on the same arc line, and the second electrode patch The centers of several electrode units located in the same row are on the same horizontal line; the arcs on which the centers of the electrode units in the first to fourth rows of the first electrode patch are located are H1, H2, H3 and H4 respectively, the ends of the arcs H1 and H2 are set in an upward shape, and the ends of the arcs H3 and H4 are set in a downward shape, the curvature of the arc H1 is greater than the curvature of the arc H2, and the curvature of the arc H4 is greater than the curvature of the arc H3; the horizontal distance of the gap between the two electrode unit groups in the first row of the first electrode patch is greater than the horizontal distance of the gap between the two electrode unit groups in the second row of the first electrode patch; the horizontal distance of the gap between the two electrode unit groups in the same row of the second electrode patch is greater than the horizontal distance of the gap between the two electrode unit groups in the first row of the first electrode patch.

2. The tumor treating field system according to claim 1, wherein: In the first electrode patch, the electrode unit group located between the second and third rows is arranged horizontally, and the other electrode unit groups are arranged inclinedly. The angle between the line connecting the centers of the two electrode units of the inclined electrode unit group and the horizontal line is 8°-12°.

3. The tumor treating field system according to claim 2, wherein: The diameter of the electrode unit is 18 mm to 22 mm, and the center distance between two electrode units in the electrode unit group is 32 mm to 35 mm.

4. The tumor treating field system according to claim 1, wherein: The central angle of the arc segment occupied by the corresponding electrode unit group on the arc H1 is 11°-21°.

5. The tumor treating field system according to claim 4, wherein: The central angle of the arc segment occupied by the corresponding electrode unit group on the arc H2 is 7°-11°.

6. The tumor treating field system according to claim 1, wherein: The horizontal lines where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the second electrode patch are located are L1, L2, L3 and L4 respectively, and the vertical distance between adjacent horizontal lines is greater than the vertical distance between two of the electrode units in the first electrode patch that are located in the second column and in the first and second rows respectively.

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