Artificial radionuclide dispensing method and dispensing workstation

Abstract

This invention relates to a method for dispensing artificial radiopharmaceuticals and its dispensing workstation. To improve the integration of protective dispensing for artificial radiopharmaceuticals, it utilizes a top chamber equipped with a clean air system, an upper shielded chamber with a dispensing and capping device, a lower shielded chamber with an activity meter well, and a bottom chamber with a bottle-dropping and capping output device. A vertical drop pipe for collective bottles is provided from the dispensing and capping device to the bottle-dropping and capping output device, passing through the inner cavity of the activity meter well. Upper and lower output valves are respectively provided at the top and bottom of the vertical drop pipe, or valves are respectively provided at the top of the vertical drop pipe and above and below the activity meter well. The upper input valve and lower output valve control the input and output of the collective bottles in the vertical drop pipe after filling and capping. The activity detection valve and lower output valve are used to close the vertical drop pipe for collective bottles at the activity meter well during activity detection. A release mechanism is located in the middle of the inner cavity of the activity meter well to stop the release of the vertically sliding collective bottles. It has the advantages of high vertical integration and good protection.

Description

Technical Field

[0001] This invention relates to an artificial radionuclide drug dispensing device, and more particularly to an artificial radionuclide drug dispensing method and its dispensing workstation. Background Technology

[0002] An existing 18F radiation-proof filling chamber, document number CN219313239U, includes a vertical shielding cabinet with a central partition, lighting equipment, and ventilation equipment. Its distinguishing feature is that the airtight, heated front shielding door of the central partition is pivotally connected to a lead-glass observation window, and there are operating handholes on both sides for airtight, pivotally connected shielding hand doors. Below the central partition, an auxiliary chamber has an airtight, pivotally connected lead-glass door for drug delivery and an airtight, pivotally connected lead-glass door for sharps container delivery. Behind the airtight, pivotally connected lead-glass door for drug delivery, the auxiliary chamber has a collective drug protection container and a personal drug delivery syringe delivery compartment. The collective drug protection containers are horizontally slidable side-by-side on the bottom plate of the delivery compartment. The weighing platform and the personal protective equipment (PPE) syringe horizontal sliding weighing platform are located side-by-side on the bottom plate of the entry / exit chamber, with vertical lifting mechanisms for positioning the collective protective equipment canisters and PPE syringes arranged vertically between the horizontal sliding weighing platform and the central partition. The front panel of the auxiliary room is equipped with controllers for electrically controlling the vertical lifting mechanisms for the collective protective equipment canisters and PPE syringes, as well as the horizontal sliding weighing platforms for the collective protective equipment canisters and PPE syringes. The airtight hinged lead glass doors for the canisters are equipped with normally closed switches that restrict the activation of the vertical lifting mechanisms when the doors are open. Airtight hinged shielded door panels on both sides open in opposite directions. Airtight hinged lead glass doors for the canisters and sharps boxes also open in opposite directions. Below the auxiliary room, the vertical shielded cabinet has an equipment room and a spare storage room, each equipped with an airtight door and a vertical lifting mechanism. The airtight hot chamber features a fully rounded mirror inner wall. After the controller is fed into the collective medicine protection container via a horizontal sliding weighing platform and the airtight hinged lead glass door for medicine entry / exit is closed, it is then moved upwards into the hot chamber position of the collective medicine protection container via a vertical lifting mechanism. The bottom plate of the auxiliary chamber behind the airtight hinged lead glass door for the sharps box supports the sharps box. The front of the partition platform features lifting and protective wells for the collective medicine protection container and the personal medication syringe, each equipped with a manually sealed cap, as well as a sharps separation and insertion port. The rear features an activity meter measuring well and an 18F automatic dispensing device. The sharps box has a sharps separation and insertion port. From left to right, the front of the partition platform features lifting and protective wells for the collective medicine protection container and the personal medication syringe, each equipped with a sealed cap, as well as a sharps separation and insertion port. The 18F automatic dispensing device is located behind the lifting and protective wells for the collective medicine protection container and the personal medication syringe, and the activity meter measuring well is located behind the sharps separation and insertion port. The sharps separation inlet is located at the left front of the activity meter measuring well. It consists of a circular syringe needle inlet at the left front and a horizontally elongated syringe inlet at the right rear. The sharps box has a circular opening and a horizontally elongated opening corresponding to the circular syringe needle inlet at the left front and the horizontally elongated syringe inlet at the right rear, respectively. The 18F automatic dispensing device is equipped with a downward-automatic docking mechanism for the liquid output tube rack of the personal medication protective syringe needle tip at the upper stop position of the lifting and protective well.The 18F automatic dispensing device connects to the collective medicine bottles inside the collective medicine protective tank via a suction pipe. The medicine output pipe rack mechanism is equipped with a vertically positioned filling connector that mates with the injection needle tip of a personal medicine protective syringe. The 18F automatic dispensing device connects to this vertically positioned filling connector via a delivery pipe. The front panel of the airtight hot chamber is equipped with an intelligent lock controlling the front shielded door of the airtight hot chamber. The front panel of the auxiliary chamber is equipped with the control buttons for the controller, or with the controller's control buttons and a control display. The upper front panel of the airtight hot chamber is equipped with an intelligent gas phase pressure gauge electrically connected to the controller. Above the upper front panel of the airtight hot chamber, on the front panel of the top chamber, is a fresh air supply and purification air inlet equipped with a high-efficiency filter. The bottom plate of the top chamber is equipped with an air outlet connected to the purification air inlet. An exhaust fan on the bottom plate of the top chamber connects downwards to the air inlets of the airtight hot chamber and the auxiliary chamber via an air intake pipe, and upwards to an outdoor exhaust pipe. An external filtration chamber equipped with an activated carbon filter and a solid-phase high-efficiency filter is located between the exhaust fan and the air intake pipe. It boasts advantages such as convenient and quick operation, and can well meet the requirements of 18F strong radiation protection filling. However, practical application has revealed that it still has some drawbacks, including inconvenient activity testing, and the vertical lifting and horizontal sliding of the collective medicine protection tank is relatively cumbersome and difficult to control.

[0003] A rapid purification and extraction device for solid target nuclides, document number CN116271960A, is described. It consists of a main micro-metering pump with a main pipeline upstream, connected in series with a concentrated hydrochloric acid three-way electrically controlled valve, a dilute hydrochloric acid three-way electrically controlled valve, a pure water three-way electrically controlled valve, and a backup three-way electrically controlled valve. A suction needle from a concentrated hydrochloric acid bottle with a sealed rubber stopper and a filter-venting needle is connected to the bypass port of the concentrated hydrochloric acid three-way electrically controlled valve via a pipeline; a suction needle from a dilute hydrochloric acid bottle with a sealed rubber stopper and a filter-venting needle is connected to the bypass port of the dilute hydrochloric acid three-way electrically controlled valve via a pipeline; a suction needle from a pure water bottle with a sealed rubber stopper and a filter-venting needle is connected to the bypass port of the pure water three-way electrically controlled valve via a pipeline; and an injection needle from a backup bottle with a sealed rubber stopper and a suction needle from a gas supply bottle with a sealed rubber stopper and a filter-venting needle are respectively connected to the second and third ports of the backup three-way electrically controlled valve via pipelines. The main micro-metering pump is located downstream of... Downstream, the pipeline sequentially connects a flushing three-way electrically controlled valve, an extraction three-way electrically controlled valve, a chromatography three-way electrically controlled valve, and an oxalic acid three-way electrically controlled valve. The bypass port of the flushing three-way electrically controlled valve is connected via a pipeline to a flushing needle extending to the top of the conical-bottom flushing cup. The bypass port of the extraction three-way electrically controlled valve is connected to the extraction tube of the series-connected auxiliary micro-metering pump and filter; the lower end of the extraction tube extends into the bottom of the conical-bottom flushing cup. The bypass port of the chromatography three-way electrically controlled valve is connected to the upper end of the chromatography tube. The lower end of the chromatography tube is connected via a separating three-way electrically controlled valve to the finished product outlet tube leading to the finished product cup and the waste liquid outlet tube leading to the waste liquid container, respectively. One port of the oxalic acid three-way electrically controlled valve is connected to an electrically controlled oxalic acid injector. The suction needle of the oxalic acid aqueous solution bottle with a sealed rubber stopper and filter venting needle is connected via a pipeline to the other port of the oxalic acid three-way electrically controlled valve. The electrically controlled oxalic acid injector, all micro-metering pumps, and all three-way electrically controlled valves are electrically connected to an intelligent controller. The metering and delivery valve-controlled pipeline, mainly composed of main and auxiliary micro metering pumps and related three-way valves, can be applied to the filling of radionuclide drugs. However, the overall artificial radionuclide drug dispensing method and its dispensing workstation technology based on this metering and delivery valve-controlled pipeline are still a gap in this field and require further innovation. In particular, a comprehensive artificial radionuclide drug dispensing method and its dispensing workstation that integrates the process of dispensing and sealing the mother liquor bottle from the protective container to the collective drug bottle, as well as the activity detection of the dispensed and sealed collective drug bottles and their placement into the protective container, still requires further innovation. Summary of the Invention

[0004] The purpose of this invention is to overcome the aforementioned deficiencies of the prior art and provide a method for dispensing artificial radionuclide drugs. Furthermore, this invention aims to provide a dispensing workstation for implementing this method. This method and workstation integrate the processes of dispensing and capping the mother liquor from the protective container to the collective drug bottles, as well as performing activity detection on the capped collective drug bottles and placing them into the protective container.

[0005] To achieve the above objectives, the artificial radionuclide drug dispensing method of the present invention utilizes a top chamber equipped with a clean air device, an upper shielded chamber equipped with a dispensing and capping device, a lower shielded chamber equipped with an activity meter well, and a bottom chamber equipped with a bottle drop and capping output device, arranged from top to bottom. A vertical drop pipe for the collective medicine bottles, passing through the inner cavity of the activity meter well, is installed from the dispensing and capping device in the upper shielded chamber to the bottle drop and capping output device in the bottom chamber. This pipe facilitates the downward transport and activity testing of the filled and capped collective medicine bottles. An upper input valve and a lower output valve are respectively installed at the upper and lower parts of the vertical drop pipe, or an upper input valve is installed at the upper part of the vertical drop pipe and above and below the activity meter well. The valves, including the activity detection valve and the lower output valve, as well as the upper input valve and the lower output valve, are used to control the input and output of the collective medicine bottles in the vertical sliding pipe of the collective medicine bottles after filling and capping. The activity detection valve and the lower output valve are used to close the vertical sliding pipe of the collective medicine bottles at the activity meter well during activity detection. The vertical sliding pipe of the collective medicine bottles is sealed and connected to the upper and lower cavities of the activity meter well to close the activity meter well opening. The vertical sliding pipe of the collective medicine bottles is equipped with a collective medicine bottle interception and release mechanism located in the middle of the inner cavity of the activity meter well to provide the time and position conditions for detecting the activity of the collective medicine bottles after filling and capping. The air purification device in the top chamber can promptly carry the nuclear contaminated air generated in the workstation to the downstream disposal and treatment facilities that meet the regulations. The dispensing and capping device in the upper shielded chamber completes the dispensing and capping of the mother liquor bottles into the collective medicine bottles. After dispensing and capping, the collective medicine bottles, via a vertical sliding pipe, are transported from the dispensing and capping device to the bottle-dropping cap output device. During this descent, the collective medicine activity is temporarily stopped by a bottle-stopping mechanism within the activity meter well, thus completing the collective medicine activity test. After the activity test is completed, the dispensing and capping collective medicine bottles are released by the bottle-stopping mechanism and continue falling through the vertical sliding pipe into the collective medicine bottle protective container on the bottle-dropping cap output device. The bottle-dropping cap output device then attaches the matching protective cap and provides or outputs the protective cap and the collective medicine bottle protective container containing the dispensing and capping collective medicine bottles. In particular, the upper input valve and the lower output valve do not open simultaneously, or the upper input valve, the activity detection valve, and the lower output valve do not open simultaneously, ensuring that air does not leak out of the upper shielding chamber during the downward movement of the group of bottles after dispensing and capping. Furthermore, the air in the upper shielding chamber or both upper and lower shielding chambers can be refreshed and exhausted to safe disposal facilities through the air purification device in the top chamber. It integrates the functions of transferring the mother liquor bottle from the protective tank to the dispensing and capping of the group of bottles, as well as the activity detection of the dispensing and capping group of bottles, and the placement of protective caps on the group of bottles into a single unit. It boasts advantages such as high vertical integration and excellent protection.

[0006] As an optimization, during activity testing, the vertical drop pipe of the collective medicine bottles is temporarily stopped by a temporary air suspension device located in the middle of the activity meter well cavity, or during activity testing, the vertical drop pipe of the collective medicine bottles is temporarily stopped by a temporary narrowing device located in the middle of the activity meter well cavity. The temporary air suspension device is more durable and easier to make airtight in the vertical drop pipe of the collective medicine bottles compared to the temporary narrowing device, and the temporary narrowing device is easier to control compared to the temporary air suspension device.

[0007] As an optimization, the temporary air suspension device involves setting a variable-diameter pipe section in the middle of the activity meter well's vertical drop pipe for the collective medicine bottle. During activity testing, the collective medicine bottle is temporarily suspended at the variable-diameter pipe section by an upward-inhaling airflow or a downward-blowing airflow. After the upward-inhaling and downward-blowing airflows stop, the collective medicine bottle is released to continue its descent. When using an expanded-diameter pipe section, the bottom of the collective medicine bottle stops between the expanded-diameter pipe section and the lower vertical drop pipe for the collective medicine bottle. When using a narrow-diameter pipe section, the bottom of the collective medicine bottle stops between the upper vertical drop pipe for the collective medicine bottle and the narrow-diameter pipe section. Compared to the narrow-diameter pipe section, the expanded-diameter pipe section can relatively reduce the inner diameter of the vertical drop pipe for the collective medicine bottle, which is beneficial for the slow descent of the collective medicine bottle. The temporary narrowing device temporarily narrows the vertical drop pipe for the collective medicine bottle at the middle of the activity meter well's inner cavity during activity testing, stopping the descending collective medicine bottle. After the activity test is completed, the narrowed vertical drop pipe for the collective medicine bottle returns to its initial state, and the collective medicine bottle is released to continue its descent. Narrowing means that the inner diameter is smaller than the outer diameter of the collective medicine bottle after narrowing. Compared with the above, this eliminates the need for a forced airflow device. An upper bypass tee and a lower bypass tee are respectively installed on the vertical sliding pipe of the collective medicine bottle between the upper input valve or activity detection valve and the lower output valve, located above and below the activity meter well. A bypass fan is installed on the bypass loop pipe between the upper and lower bypass tees to generate an upward suction airflow or a downward blowing airflow at the diameter-reducing pipe section. With the upper input valve or activity detection valve and the lower output valve simultaneously closed, using this dedicated bypass fan to generate the upward suction airflow or downward blowing airflow is easier to control than using a clean air device, and more importantly, it does not affect activity detection. The temporary narrowing device consists of an upper and lower pipe section of the vertically sliding tube for the collective medicine bottle, vertically connected at the center of the activity meter well via a flexible hose or tubular cable. One section is fixed and the other is pivotal. The pivotal section is equipped with a rotation drive mechanism. During rotation, the flexible hose or tubular cable is twisted to narrow its inner diameter, stopping the vertically sliding collective medicine bottle. The bottle is released when the tube is initially rotated. Alternatively, one section is fixed and the other is a vertically sliding section equipped with a lifting drive mechanism. An elastic ring with a diameter smaller than the outer diameter of the collective medicine bottle is bound around the outer periphery of the flexible hose or tubular cable. When the lifting drive mechanism is in the rising position, the elastic ring binds the flexible hose or tubular cable, making its inner diameter smaller than the outer diameter of the collective medicine bottle, stopping the vertically sliding collective medicine bottle. When the lifting drive mechanism is in the descending position, the flexible hose or tubular cable is vertically straightened, widening its inner diameter to be larger than the outer diameter of the collective medicine bottle, releasing the bottle. Whether it is stretching or rotating, a pivot section or a vertical sliding section is required to be fitted with a movable seal sleeve at the activity meter wellhead. The movable seal sleeve can be a soft annular seal sleeve or an airtight sliding sleeve.

[0008] As an optimization, the dispensing and capping device consists of an L-shaped base on the rear center of the upper shielding chamber floor, with an upstream metering and conveying valve control pipeline connecting to the mother liquor protection tank at the front of the upper part. A filling head is located on one side of the lower part of the L-shaped base, connected to a directional filling robotic arm at the downstream end of the metering and conveying valve control pipeline, which rotates between the waiting position and the filling position. A downward capping machine is located at the front of the upper extension of the upper part of the L-shaped base to the other side, or at the upper front of the rear extension of the L-shaped base to the other side, leading to the capping position. A collection device is located at the end of the lower part of the L-shaped base on the other side, rotating between the filling and capping positions. The bottle holder features a swivel-lifting filling station type robotic arm for packaging and supporting group medicine bottles. The upper shielding chamber has a transparent lead glass front screen with two parallel through-holes. At least one of these through-holes is sealed by a shielding sleeve to accommodate a surgical laparoscopic gripper used for picking up and placing group medicine bottles and caps. The left side of the upper shielding chamber floor, from back to front, houses the placement position for the mother liquor protection tank and the material lifting well for the mother liquor protection tank and the group medicine bottles with caps. The lifting well extends from the lower shielding chamber with a shielded front door to the lifting well opening. The upper shielding chamber floor has a placement station for group medicine bottles with caps in front of the L-shaped base. The downward capping machine is a chuck-type capping machine. The surgical laparoscopic gripper grasps the group medicine bottles and places them into the group medicine bottle holder at the end of the swivel-lifting filling station type robotic arm located at the filling position. The metering and delivery valve-controlled pipeline quantitatively draws the medicine from the upstream mother liquor protection tank and inserts its filling head into the bottle opening on the bottle holder of the directional lifting-type collective bottle sealing support robot arm located at the filling position for quantitative filling. The directional filling robot arm fills the collective bottles at the filling position. When in the waiting position, the directional filling robot arm clears the collective bottles at the filling position to facilitate placement. The directional lifting-type collective bottle automatic sealing support robot arm receives the collective bottles at the filling position, providing conditions for accepting filling and also providing the prerequisite for the filled and capped collective bottles to slide down the vertical pipe. The caps are then applied to the filled collective bottles at the filling position using surgical laparoscopic grippers. Finally, the directional lifting-type collective bottle automatic sealing support robot arm presses down to seal the collective bottles in the capping position. The metering and delivery valve-controlled pipeline, the directional filling robotic arm, the downward capping machine, and the directional lifting filling seat-type automatic bottle sealing and support robotic arm are all intelligently controlled. The mother liquor protection tank is a 3.6mmPb total drug quantity protection tank after synthesis. The metering and delivery valve-controlled pipeline includes a main micro-metering pump for outputting radionuclide drugs and a secondary micro-metering pump for injecting excipients into the output radionuclide drugs as needed. This satisfies both the needs of direct filling and the needs of excipient preparation and filling, significantly enhancing applicability compared to simple direct filling. The micro-metering pump is a micro-metering peristaltic pump, which can improve the accuracy and reliability of micro-metering.

[0009] Two parallel through holes are respectively sealed with shielding sleeves for a left surgical laparoscopic gripper used to place capped group medicine bottles from the medicine bottle material lifting well to the medicine bottle placement station, and a right surgical laparoscopic gripper used to place capped group medicine bottles from the medicine bottle placement station to the group medicine bottle holder of the swivel-lifting filling seat type group medicine bottle sealing support robot arm, and to pick up and put away bottle caps. The left and right surgical laparoscopic grippers are configured side by side, which reduces the difficulty of operation and improves the accuracy of operation compared with a single surgical laparoscopic gripper. The capped group medicine bottles are lightly pressed onto the top of the group medicine bottle. The front part of the L-shaped base is equipped with the swivel-lifting filling seat type group medicine bottle automatic sealing support robot arm's swivel-lifting drive mechanism on one side. The downward filling head of the swivel-lifting filling robot arm corresponds vertically with the group medicine bottle holder at the end of the swivel-lifting filling seat type group medicine bottle automatic sealing support robot arm at the filling position. This design helps ensure correct alignment between the sub-liquid bottle opening on the sub-liquid bottle holder and the downward filling head, simplifying operation. The upper shielding chamber's transparent lead glass front screen has left and right airtight lead glass doors located outside the two parallel through-holes. Each door is fitted with a left and right inner extension glove, which allows for easy extension of the arm to perform additional tasks while maintaining the airtightness of the upper shielding chamber. Above the left and right airtight lead glass doors, the upper shielding chamber's transparent lead glass front screen has a vertically oriented, angled transparent lead glass observation window, facilitating accurate observation of the internal conditions. A touch screen display is located at the lower front of the top chamber for convenient external observation and operation. A spare activity detection well is located on the right side of the upper shielding chamber's floor plate, allowing for activity testing of collective vials after non-standard filling and capping, meeting special activity testing needs. The lower shielding chamber is pivotally connected to the left and right transparent lead glass doors, facilitating maintenance of the internal equipment through these doors.

[0010] The ventilation ducts upstream and downstream of the air purification unit are equipped with airtight check valves that automatically close after ventilation stops. This ensures that after ventilation stops, polluted air discharged from the internal ducts will not flow back into the station, and vice versa. The airtight check valve consists of a medium-thickness expanded pipe section with axially sliding, hollowed-out supports spaced along its inner axis. A forward-extending pipe seat is located in front of the rear hollowed-out support within the medium-thickness expanded pipe section. A valve plate, sealed and fixedly fitted onto the central shaft, engages with the front end of the forward-extending pipe seat. An elastic sealing plate, also sealingly fitted onto the valve plate, engages with the front end of the forward-extending pipe seat. A support spring is fitted over the central shaft between the valve plate and the front hollowed-out support. These front and rear hollowed-out supports provide more reliable and durable axial sliding support for the central shaft. The medium-thickness expanded pipe section features a front and rear hollowed-out support, an extended pipe seat, a valve plate with its elastic sealing plate, a central shaft, and its supporting spring. This design provides better fluid flow compared to pipe sections of the same or narrow diameter when the valve plate and its elastic sealing plate are away from the extended pipe seat, easily achieving a flow rate no lower than that of the connected pipeline itself. Because the extended pipe seat and valve plate are sealed by the elastic sealing plate under spring pressure, the narrow sealing contact surface not only facilitates sealing but also ensures high sealing performance and minimizes the risk of sealing failure. Therefore, it offers excellent fluid flow, high sealing efficiency, and easy self-opening and closing based on fluid flow. It is particularly suitable for the self-opening and closing control of negative pressure ventilation pipelines in artificial nuclear drug input / output to activity wells and dispensing hot chambers. Specifically, when negative or positive air pressure disappears, this medical one-way valve automatically and tightly seals the pipeline, preventing leakage of radioactive contaminant air.

[0011] The elastic sealing sheet is a silicone elastic diaphragm. Compared with other elastic materials, silicone elastic diaphragms are less prone to contamination, have better elasticity, and are more durable, making them particularly suitable for press-fit sealing with the front end of the extension tube seat. The elastic sealing sheet is annular, minimizing gaps that could lead to residue between it and the valve plate. The inner ring of the annular elastic sealing sheet is sealed and secured to the valve plate by an annular pressure plate and its annularly distributed fastening pins, which, compared to adhesive bonding, does not affect or contaminate the flowing medication. Furthermore, the inner ring fixation provides better flowability than the outer ring fixation. The front hollow bracket is forward-mounted to accommodate the front of the supporting spring in a protruding hollow barrel shape. This increases the spring length without increasing the distance between the front and rear hollow brackets, significantly optimizing the sealing opening performance under spring support, resulting in better reliability and operability. The protruding hollow barrel shape is either a straight barrel or a conical barrel shape that is narrower at the front and wider at the back. Compared to a straight barrel shape, the conical barrel shape better restrains the front end of the supporting spring, improving sealing reliability. The inner cavity of the hollow conical barrel, which does not contact the supporting spring, facilitates flow. The extended tube seat is a trapezoidal tube wall type extended tube seat that is narrow at the front and wide at the back, which is easy to press together to achieve a reliable seal. It is also a ring-shaped knife-edge type extended tube seat that is thinner at the front and thicker at the back, which is even easier to press together to achieve a reliable seal. The trapezoid is either isosceles or right-angled. A right-angled trapezoid occupies less flow space than an isosceles trapezoid, while a small-angled isosceles trapezoid provides some elastic sealing support. The rear hollowed-out bracket has a forward-facing boss for fitting the base of the support spring, which provides good stability during spring extension and contraction, thus improving the sealing performance. The medium-thickness expanding tube section is formed by sealing and fastening a front expanding tube cap section with a front hollowed-out bracket and a rear expanding tube seat section with a rear hollowed-out bracket and an extended tube seat. This facilitates manufacturing, disassembly, and maintenance. The front expander cap section is a stepped, rear-extending flared section that is narrower at the front and wider at the back. The front hollowed-out support is located on the rear-extending flared section's middle rear-extending step, facilitating integral injection molding. The rear expander seat section is a convex annular, front-extending flared section that is wider at the front and narrower at the back. The rear hollowed-out support is located on the inner circumference of the convex ring in the middle of the front-extending flared section, and the front extender seat is positioned forward from the convex ring in the middle of the front-extending flared section. This also facilitates integral injection molding and allows for a more spacious flow path for the fluid. The front expander cap section is a rearward flared tube extending from a straight front end. The rear end of the rearward flared tube is connected to an outwardly extending ring platform with a front hollowed-out support. The outer circumference of the outwardly extending ring platform extends rearward to form a rearward tube seat for sealing and engaging with the rear expander seat section. The rear expander seat section is a forward flared tube extending from a straight rear end. The forward flared tube extends forward to form a forward tube seat for sealing and engaging with the front expander cap section. An inner convex ring is provided in the middle of the inner cavity of the forward flared tube, and the rear hollowed-out support is provided on the inner circumference of the inner convex ring. The forward extending tube seat is positioned forward from the inner convex ring. The inner and outer sleeve joint between the rear end of the rear tube seat and the front end of the front tube seat is sealed with a silicone sealing ring. The rear end of the rear tube seat and the front end of the front tube seat are screwed together. A silicone sealing ring is pressed between the front end of the inner sleeve tube seat and the inner ring platform of the outer sleeve tube seat, which facilitates disassembly and maintenance while ensuring a reliable sealing connection.The rearward-facing trumpet-shaped expander, with its extended annular platform and front hollowed-out support, increases fluid circulation space and ensures smooth flow. An inner convex ring is located in the middle of the inner cavity of the forward-facing trumpet-shaped expander, with the rear hollowed-out support positioned on its inner circumference. The forward-extending tube seat, positioned forward from the inner convex ring, ensures a tight seal while also increasing fluid circulation space and ensuring smooth flow. The rearward extension of the annular platform, used for sealing and engaging with the rear expander seat, and the forward extension of the trumpet-shaped expander, used for sealing and engaging with the front expander cap, facilitate a secure seal and increase flow space. The front and rear straight tube ports are used to connect upstream and downstream flow lines, especially medical lines. The connection can be a direct external connection or a threaded connection with a silicone sealing ring sealing the mating ring surface. It has the advantages of good fluid flow, high sealing efficiency, easy self-opening and closing by fluid, and is particularly suitable for the self-opening and closing control of the negative pressure ventilation pipeline of the artificial nuclear drug input and output to the activity well and the dispensing hot chamber. That is, when the negative or positive air pressure disappears, the pipeline will be automatically and tightly sealed by this medical one-way valve to prevent the leakage of radioactive contamination air.

[0012] As an optimization, the bottle-dropping cap output device consists of a horizontal slide rail at the bottom of the chamber, connected to a horizontal slide frame and an extension push-pull frame. The base of the push-pull frame is equipped with an upward-facing protective can holder for the collective medicine bottles, positioned at the inner stop and directly facing the lower port of the vertical drop pipe. Any multiple collective medicine bottles in the vertical drop pipe are protected by a buffer device to prevent damage during the fall of the bottled bottles after filling and capping. Pushing the push-pull frame to the inner stop position ensures that the upward-facing protective can holder is directly facing the lower port of the vertical drop pipe, accurately receiving the filled and capped bottles. Pulling it outwards further facilitates the fastening of the protective caps that fit the protective can holder. The collective bottle falling buffer device after filling and capping includes a collective bottle protective container with an upper open-topped compartment for accommodating the filled and capped collective bottles, equipped with an elastic cushioning sleeve, and a collective bottle vertical sliding pipe with an inner cavity containing elastic densely distributed support fibers to slow down the downward speed of the collective bottles after filling and capping. An external handle and a protective cap pushing mechanism, manually operated by a component of the handle, push the protective cap onto the collective bottle protective container's support. This pushing mechanism ensures the pushed protective cap falls accurately onto the collective bottle protective container. This manually operated protective cap pushing mechanism prevents the human body from being positioned above the upper open-topped collective bottle protective container when fastening the protective cap, thus avoiding unnecessary artificial nuclear radiation.

[0013] The push-pull frame is equipped with a handle and a protective cap pushing mechanism, operated by a manual component within the handle, to push the protective caps onto the collective medicine bottle protective container holder. This mechanism ensures the pushed protective caps fall accurately onto the collective medicine bottle protective container. This manually operated cap pushing mechanism prevents the human body from being positioned above the upward-opening collective medicine bottle protective container when fastening the protective cap, thus avoiding unnecessary artificial nuclear radiation.

[0014] The dispensing workstation for implementing the artificial radionuclide drug dispensing method of the present invention is characterized by comprising, from top to bottom, a top chamber equipped with a clean air device, an upper shielded chamber equipped with a dispensing and capping device, a lower shielded chamber equipped with an activity meter well, and a bottom chamber equipped with a bottle drop and capping output device. A vertical drop pipe for collecting and capping bottles is installed from the dispensing and capping device in the upper shielded chamber to the bottle drop and capping output device in the bottom chamber, passing through the inner cavity of the activity meter well. This vertical drop pipe is used for downward transport and activity testing of the collected bottles after filling and capping. An upper input valve and a lower output valve are respectively installed at the upper and lower parts of the vertical drop pipe to collect the bottles after filling and capping. The downward input / output control or the upper part of the collective bottle vertical drop pipeline and the upper and lower parts of the activity meter well are respectively equipped with an upper input valve, an activity detection valve, and a lower output valve. After filling and capping, the downward input / output control of the collective bottle and the sealing control of the collective bottle vertical drop pipeline during activity detection are implemented. The collective bottle vertical drop pipeline is sealed and connected to the upper and lower chambers of the activity meter well to seal the activity meter well opening. The collective bottle vertical drop pipeline is located in the middle of the activity meter well's inner cavity to stop the release of the vertically sliding collective bottle, providing time and position conditions for detecting the activity of the collective bottle after filling and capping. The air purification device in the top chamber can promptly carry the nuclear contaminated air generated in the workstation to the downstream disposal and treatment facilities that meet the regulations. The dispensing and capping device in the upper shielded chamber completes the dispensing and capping of the mother liquor bottles into the collective medicine bottles. After dispensing and capping, the collective medicine bottles, via a vertical sliding pipe, are transported from the dispensing and capping device to the bottle-dropping cap output device. During this descent, the collective medicine activity is temporarily stopped by a bottle-stopping mechanism within the activity meter well, thus completing the collective medicine activity test. After the activity test is completed, the dispensing and capping collective medicine bottles are released by the bottle-stopping mechanism and continue falling through the vertical sliding pipe into the collective medicine bottle protective container on the bottle-dropping cap output device. The bottle-dropping cap output device then attaches the matching protective cap and provides or outputs the protective cap and the collective medicine bottle protective container containing the dispensing and capping collective medicine bottles. In particular, the upper input valve and the lower output valve do not open simultaneously, or the upper input valve, the activity detection valve, and the lower output valve do not open simultaneously, ensuring that air does not leak out of the upper shielding chamber during the downward movement of the group of bottles after dispensing and capping. Furthermore, the air in the upper shielding chamber or both upper and lower shielding chambers can be refreshed and exhausted to safe disposal facilities through the air purification device in the top chamber. It integrates the functions of transferring the mother liquor bottle from the protective tank to the dispensing and capping of the group of bottles, as well as the activity detection of the dispensing and capping group of bottles, and the placement of protective caps on the group of bottles into a single unit. It boasts advantages such as high vertical integration and excellent protection.

[0015] As an optimization, the collective medicine bottle release mechanism is either a temporary air suspension device where the vertical drop pipe of the collective medicine bottle is positioned in the middle of the activity meter well cavity to stop the collective medicine bottle during activity testing, or a temporary narrow channel device where the vertical drop pipe of the collective medicine bottle is positioned in the middle of the activity meter well cavity during activity testing. The temporary air suspension device is more durable and easier to make airtight in the vertical drop pipe of the collective medicine bottle, and the temporary narrow channel device is easier to control than the temporary air suspension device.

[0016] As an optimization, the temporary air suspension device is a variable-diameter pipe section installed in the middle of the activity meter well cavity of the vertical drop pipe for the collective medicine bottle. During activity testing, the collective medicine bottle is temporarily suspended at the variable-diameter pipe section by an upward suction airflow or a downward blowing airflow. After the upward suction airflow and downward blowing airflow are stopped, the collective medicine bottle is released to continue its downward descent. When an expanded-diameter pipe section is used, the bottom of the collective medicine bottle stops between the expanded-diameter pipe section and the lower vertical drop pipe for the collective medicine bottle; when a narrow-diameter pipe section is used, the bottom of the collective medicine bottle stops between the upper vertical drop pipe for the collective medicine bottle and the narrow-diameter pipe section. Compared with the narrow-diameter pipe section, the expanded-diameter pipe section can relatively reduce the inner diameter of the vertical drop pipe for the collective medicine bottle, which is beneficial for the slow descent of the collective medicine bottle. The temporary narrowing device, during activity testing, temporarily narrows the vertical sliding channel of the collective medicine bottle at the middle position of the activity meter well, stopping the sliding of the bottle. After the activity test is completed, the narrowed channel is returned to its initial state, releasing the bottle to continue its descent. Narrowing means that the inner diameter after narrowing is smaller than the outer diameter of the bottle. Compared to the above, this eliminates the need for a forced airflow device.

[0017] The vertical drop-off pipe of the collective medicine bottle is equipped with an upper bypass tee and a lower bypass tee located above and below the activity meter well, respectively, between the upper input valve or activity detection valve and the lower output valve. A bypass fan is installed on the bypass loop pipe between the upper and lower bypass tees to generate an upward suction airflow or a downward blowing airflow at the variable diameter pipe section. Under the premise that the upper input valve or activity detection valve and the lower output valve are closed at the same time, the upward suction airflow or downward blowing airflow generated by this dedicated bypass fan is easier to control than using a clean air device, and more importantly, it does not affect the activity detection. The temporary narrowing device consists of an upper and lower pipe section of the vertically sliding tube for the collective medicine bottle, vertically connected at the center of the activity meter well via a flexible hose or tubular cable. One section is fixed and the other is pivotal. The pivotal section is equipped with a rotation drive mechanism. During rotation, the flexible hose or tubular cable is twisted to narrow its inner diameter, stopping the vertically sliding collective medicine bottle. The bottle is released when the tube is initially rotated. Alternatively, one section is fixed and the other is a vertically sliding section equipped with a lifting drive mechanism. An elastic ring with a diameter smaller than the outer diameter of the collective medicine bottle is bound around the outer periphery of the flexible hose or tubular cable. When the lifting drive mechanism is in the rising position, the elastic ring binds the flexible hose or tubular cable, making its inner diameter smaller than the outer diameter of the collective medicine bottle, stopping the vertically sliding collective medicine bottle. When the lifting drive mechanism is in the descending position, the flexible hose or tubular cable is vertically straightened, widening its inner diameter to be larger than the outer diameter of the collective medicine bottle, releasing the bottle. Whether it is stretching or rotating, a pivot section or a vertical sliding section is required to be fitted with a movable seal sleeve at the activity meter wellhead. The movable seal sleeve can be a soft annular seal sleeve or an airtight sliding sleeve.

[0018] As an optimization, the dispensing and capping device consists of an L-shaped base on the rear center of the upper shielding chamber floor, with an upstream metering and conveying valve control pipeline connecting to the mother liquor protection tank at the front of the upper part. A filling head is located on one side of the lower part of the L-shaped base, connected to the downstream end of the metering and conveying valve control pipeline, and a directional filling robotic arm that rotates between the waiting position and the filling position. A downward capping machine is located on the front of the upper extension of the upper part of the L-shaped base to the other side, or on the upper front of the rear extension of the L-shaped base to the other side, leading to the capping position. The other side of the lower part of the L-shaped base is located between the filling position and the capping position. A rotating, lifting-type filling station robotic arm for packaging and supporting collective medicine bottles is located at the end of the rotating, lifting-type filling station robotic arm between the filling positions. The upper shielding chamber has a transparent lead glass front screen with two parallel through holes. At least one of these through holes is sealed by a shielding sleeve to accommodate a surgical laparoscopic gripper for picking up and placing collective medicine bottles and caps. The left side of the upper shielding chamber floor, from back to front, features a placement position for the mother liquor protection tank and a material lifting well for the mother liquor protection tank and the collective medicine bottles with caps. A placement station for the collective medicine bottles with caps is located in front of the L-shaped base on the upper shielding chamber floor. The downward capping machine is a chuck-type capping machine. The surgical laparoscopic gripper picks up the collective medicine bottles and places them into the collective medicine bottle holder at the end of the rotating, lifting-type filling station robotic arm located at the filling position. The metering and delivery valve-controlled pipeline quantitatively draws the medicine from the upstream mother liquor protection tank and inserts its filling head into the bottle opening on the bottle holder of the directional lifting-type collective bottle sealing support robot arm located at the filling position for quantitative filling. The directional filling robot arm fills the collective bottles at the filling position. When in the waiting position, the directional filling robot arm clears the collective bottles at the filling position to facilitate placement. The directional lifting-type collective bottle automatic sealing support robot arm receives the collective bottles at the filling position, providing conditions for accepting filling and also providing the prerequisite for the filled and capped collective bottles to slide down the vertical pipe. The caps are then applied to the filled collective bottles at the filling position using surgical laparoscopic grippers. Finally, the directional lifting-type collective bottle automatic sealing support robot arm presses down to seal the collective bottles in the capping position. The metering and delivery valve-controlled pipeline, the directional filling robotic arm, the downward capping machine, and the directional lifting filling seat-type automatic bottle sealing and support robotic arm are all intelligently controlled. The mother liquor protection tank is a 3.6mmPb total drug quantity protection tank after synthesis. The metering and delivery valve-controlled pipeline includes a main micro-metering pump for outputting radionuclide drugs and a secondary micro-metering pump for injecting excipients into the output radionuclide drugs as needed. This satisfies both the needs of direct filling and the needs of excipient preparation and filling, significantly enhancing applicability compared to simple direct filling. The micro-metering pump is a micro-metering peristaltic pump, which can improve the accuracy and reliability of micro-metering.

[0019] Two parallel through holes are respectively sealed with shielding sleeves for a left surgical laparoscopic gripper used to place capped group medicine bottles from the medicine bottle material lifting well to the medicine bottle placement station, and a right surgical laparoscopic gripper used to place capped group medicine bottles from the medicine bottle placement station to the group medicine bottle holder of the swivel-lifting filling seat type group medicine bottle sealing support robot arm, and to pick up and put away bottle caps. The left and right surgical laparoscopic grippers are configured side by side, which reduces the difficulty of operation and improves the accuracy of operation compared with a single surgical laparoscopic gripper. The capped group medicine bottles are lightly pressed onto the top of the group medicine bottle. The front part of the L-shaped base is equipped with the swivel-lifting filling seat type group medicine bottle automatic sealing support robot arm's swivel-lifting drive mechanism on one side. The downward filling head of the swivel-lifting filling robot arm corresponds vertically with the group medicine bottle holder at the end of the swivel-lifting filling seat type group medicine bottle automatic sealing support robot arm at the filling position. This design helps ensure correct alignment between the sub-liquid bottle opening on the sub-liquid bottle holder and the downward filling head, simplifying operation. The upper shielding chamber's transparent lead glass front screen has left and right airtight lead glass doors located outside the two parallel through-holes. Each door is fitted with a left and right inner extension glove, which allows for easy extension of the arm to perform additional tasks while maintaining the airtightness of the upper shielding chamber. Above the left and right airtight lead glass doors, the upper shielding chamber's transparent lead glass front screen has a vertically oriented, angled transparent lead glass observation window, facilitating accurate observation of the internal conditions. A touch screen display is located at the lower front of the top chamber for convenient external observation and operation. A spare activity detection well is located on the right side of the upper shielding chamber's floor plate, allowing for activity testing of collective vials after non-standard filling and capping, meeting special activity testing needs. The lower shielding chamber is pivotally connected to the left and right transparent lead glass doors, facilitating maintenance of the internal equipment through these doors.

[0020] The ventilation ducts upstream and downstream of the air purification unit are equipped with airtight check valves that automatically close after ventilation stops. This ensures that after ventilation stops, polluted air discharged from the internal ducts will not flow back into the station, and vice versa. The airtight check valve consists of a medium-thickness expanded pipe section with axially sliding, hollowed-out supports spaced along its inner axis. A forward-extending pipe seat is located in front of the rear hollowed-out support within the medium-thickness expanded pipe section. A valve plate, sealed and fixedly fitted onto the central shaft, engages with the front end of the forward-extending pipe seat. An elastic sealing plate, also sealingly fitted onto the valve plate, engages with the front end of the forward-extending pipe seat. A support spring is fitted over the central shaft between the valve plate and the front hollowed-out support. These front and rear hollowed-out supports provide more reliable and durable axial sliding support for the central shaft. The medium-thickness expanded pipe section features a front and rear hollowed-out support, an extended pipe seat, a valve plate with its elastic sealing plate, a central shaft, and its supporting spring. This design provides better fluid flow compared to pipe sections of the same or narrow diameter when the valve plate and its elastic sealing plate are away from the extended pipe seat, easily achieving a flow rate no lower than that of the connected pipeline itself. Because the extended pipe seat and valve plate are sealed by the elastic sealing plate under spring pressure, the narrow sealing contact surface not only facilitates sealing but also ensures high sealing performance and minimizes the risk of sealing failure. Therefore, it offers excellent fluid flow, high sealing efficiency, and easy self-opening and closing based on fluid flow. It is particularly suitable for the self-opening and closing control of negative pressure ventilation pipelines in artificial nuclear drug input / output to activity wells and dispensing hot chambers. Specifically, when negative or positive air pressure disappears, this medical one-way valve automatically and tightly seals the pipeline, preventing leakage of radioactive contaminant air.

[0021] The elastic sealing sheet is a silicone elastic diaphragm. Compared with other elastic materials, silicone elastic diaphragms are less prone to contamination, have better elasticity, and are more durable, making them particularly suitable for press-fit sealing with the front end of the extension tube seat. The elastic sealing sheet is annular, minimizing gaps that could lead to residue between it and the valve plate. The inner ring of the annular elastic sealing sheet is sealed and secured to the valve plate by an annular pressure plate and its annularly distributed fastening pins, which, compared to adhesive bonding, does not affect or contaminate the flowing medication. Furthermore, the inner ring fixation provides better flowability than the outer ring fixation. The front hollow bracket is forward-mounted to accommodate the front of the supporting spring in a protruding hollow barrel shape. This increases the spring length without increasing the distance between the front and rear hollow brackets, significantly optimizing the sealing opening performance under spring support, resulting in better reliability and operability. The protruding hollow barrel shape is either a straight barrel or a conical barrel shape that is narrower at the front and wider at the back. Compared to a straight barrel shape, the conical barrel shape better restrains the front end of the supporting spring, improving sealing reliability. The inner cavity of the hollow conical barrel, which does not contact the supporting spring, facilitates flow. The extended tube seat is a trapezoidal tube wall type extended tube seat that is narrow at the front and wide at the back, which is easy to press together to achieve a reliable seal. It is also a ring-shaped knife-edge type extended tube seat that is thinner at the front and thicker at the back, which is even easier to press together to achieve a reliable seal. The trapezoid is either isosceles or right-angled. A right-angled trapezoid occupies less flow space than an isosceles trapezoid, while a small-angled isosceles trapezoid provides some elastic sealing support. The rear hollowed-out bracket has a forward-facing boss for fitting the base of the support spring, which provides good stability during spring extension and contraction, thus improving the sealing performance. The medium-thickness expanding tube section is formed by sealing and fastening a front expanding tube cap section with a front hollowed-out bracket and a rear expanding tube seat section with a rear hollowed-out bracket and an extended tube seat. This facilitates manufacturing, disassembly, and maintenance. The front expander cap section is a stepped, rear-extending flared section that is narrower at the front and wider at the back. The front hollowed-out support is located on the rear-extending flared section's middle rear-extending step, facilitating integral injection molding. The rear expander seat section is a convex annular, front-extending flared section that is wider at the front and narrower at the back. The rear hollowed-out support is located on the inner circumference of the convex ring in the middle of the front-extending flared section, and the front extender seat is positioned forward from the convex ring in the middle of the front-extending flared section. This also facilitates integral injection molding and allows for a more spacious flow path for the fluid. The front expander cap section is a rearward flared tube extending from a straight front end. The rear end of the rearward flared tube is connected to an outwardly extending ring platform with a front hollowed-out support. The outer circumference of the outwardly extending ring platform extends rearward to form a rearward tube seat for sealing and engaging with the rear expander seat section. The rear expander seat section is a forward flared tube extending from a straight rear end. The forward flared tube extends forward to form a forward tube seat for sealing and engaging with the front expander cap section. An inner convex ring is provided in the middle of the inner cavity of the forward flared tube, and the rear hollowed-out support is provided on the inner circumference of the inner convex ring. The forward extending tube seat is positioned forward from the inner convex ring. The inner and outer sleeve joint between the rear end of the rear tube seat and the front end of the front tube seat is sealed with a silicone sealing ring. The rear end of the rear tube seat and the front end of the front tube seat are screwed together. A silicone sealing ring is pressed between the front end of the inner sleeve tube seat and the inner ring platform of the outer sleeve tube seat, which facilitates disassembly and maintenance while ensuring a reliable sealing connection.The rearward-facing trumpet-shaped expander, with its extended annular platform and front hollowed-out support, increases fluid circulation space and ensures smooth flow. An inner convex ring is located in the middle of the inner cavity of the forward-facing trumpet-shaped expander, with the rear hollowed-out support positioned on its inner circumference. The forward-extending tube seat, positioned forward from the inner convex ring, ensures a tight seal while also increasing fluid circulation space and ensuring smooth flow. The rearward extension of the annular platform, used for sealing and engaging with the rear expander seat, and the forward extension of the trumpet-shaped expander, used for sealing and engaging with the front expander cap, facilitate a secure seal and increase flow space. The front and rear straight tube ports are used to connect upstream and downstream flow lines, especially medical lines. The connection can be a direct external connection or a threaded connection with a silicone sealing ring sealing the mating ring surface. It has the advantages of good fluid flow, high sealing efficiency, easy self-opening and closing by fluid, and is particularly suitable for the self-opening and closing control of the negative pressure ventilation pipeline of the artificial nuclear drug input and output to the activity well and the dispensing hot chamber. That is, when the negative or positive air pressure disappears, the pipeline will be automatically and tightly sealed by this medical one-way valve to prevent the leakage of radioactive contamination air.

[0022] As an optimization, the bottle-dropping and capping output device consists of a horizontal slide rail at the bottom of the chamber, connected to a horizontal slide frame and an extension push-pull frame. The base of the push-pull frame is equipped with an upward-facing protective canister support that faces the lower port of the vertical drop pipe for the collective medicine bottles from the inner stop position. Any multiple protective canisters and vertical drop pipes for the collective medicine bottles are equipped with a buffer device for the falling collective medicine bottles after filling and capping. Pushing the push-pull frame to the inner stop position ensures that the upward-facing protective canister support faces the lower port of the vertical drop pipe, accurately receiving the filled and capped collective medicine bottles. Pulling it outwards facilitates the fastening of the protective caps that match the protective canister support. The buffer device for the falling collective medicine bottles after filling and capping includes an upper open chamber in the protective canister for accommodating the filled and capped collective medicine bottles, equipped with an elastic buffer sleeve, and an inner cavity in the vertical drop pipe for the collective medicine bottles, equipped with densely distributed elastic support fibers to slow down the downward speed of the filled and capped collective medicine bottles.

[0023] The push-pull frame is equipped with a handle and a protective cap pushing mechanism, operated by a manual component within the handle, to push the protective caps onto the collective medicine bottle protective container holder. This mechanism ensures the pushed protective caps fall accurately onto the collective medicine bottle protective container. This manually operated cap pushing mechanism prevents the human body from being positioned above the upward-opening collective medicine bottle protective container when fastening the protective cap, thus avoiding unnecessary artificial nuclear radiation.

[0024] After adopting the above technical solution, the artificial radionuclide drug dispensing method and dispensing workstation of the present invention have the advantages of integrating the dispensing and sealing of the mother liquor bottle protective container into the collective drug bottle, as well as the activity detection of the collective drug bottle after dispensing and sealing, the insertion into the collective drug bottle protective container and the addition of protective caps, into one unit. It has the advantages of high vertical integration and good protection. Attached Figure Description

[0025] Figure 1 This is a side view of the structure of the dispensing workstation for implementing the artificial radionuclide dispensing method of the present invention, showing the state of the collective medicine bottle protective container to be input. Figure 2 This is a side view of the structure of the dispensing workstation used to implement the artificial radionuclide dispensing method of the present invention, showing the input of the collective medicine bottle protective container and the state of the bottle to be dispensed. Figure 3 yes Figure 2 A schematic diagram of the main view structure of the state. Figure 4 This is a front view structural schematic diagram of the dispensing and capping device of the dispensing workstation used to implement the artificial radionuclide dispensing method of the present invention. Figure 5 This is a front view structural diagram of the filling and capping device of the filling workstation used to implement the artificial radionuclide drug filling method of the present invention, in the state of waiting to be filled and positioned. Figure 6 This is a top view of the filling and capping device of the filling workstation used to implement the artificial radionuclide drug filling method of the present invention, in the state of waiting to be filled. The filling head and its associated pipelines are not shown in the figure. Figure 7 This is a top view of the filling and capping device of the filling workstation used to implement the artificial radionuclide filling method of the present invention, in the state of being ready for filling. Figure 8 This is a side view of the filling and capping device of the filling workstation used to implement the artificial radionuclide drug filling method of the present invention, in the state of being ready for filling. Figure 9 This is a side view of the filling and capping device of the filling workstation used to implement the artificial radionuclide drug filling method of the present invention, showing the filling and capping device in place. Figure 10 This is a side view of the dispensing and capping device of the dispensing workstation used to implement the artificial radionuclide dispensing method of the present invention, in the state of being filled and ready to be capped. Figure 11 This is a schematic diagram of the airtight check valve in the airtight state of the dispensing workstation used to implement the artificial radionuclide dispensing method of the present invention. Figure 12 This is a schematic diagram of the structure of the airtight check valve of the dispensing workstation used to implement the artificial radionuclide dispensing method of the present invention, which discharges the airtight state. Detailed Implementation

[0026] The artificial radionuclide drug dispensing method of this invention is realized by relying on a top chamber equipped with a clean air device, an upper shielded chamber equipped with a dispensing and capping device, a lower shielded chamber equipped with an activity meter well, and a bottom chamber equipped with a bottle drop and capping output device, arranged from top to bottom. A vertical drop pipe for collective bottles, passing through the inner cavity of the activity meter well, is set up from the dispensing and capping device in the upper shielded chamber to the bottle drop and capping output device in the bottom chamber. This vertical drop pipe facilitates the downward transport and activity testing of the filled and capped collective bottles. An upper input valve and a lower output valve are respectively installed at the upper and lower parts of the vertical drop pipe, or an upper input valve and a lower output valve are respectively installed at the upper part of the vertical drop pipe and above and below the activity meter well. The activity detection valve and lower output valve, upper input valve and lower output valve are used to control the input and output of the collective medicine bottles in the vertical sliding pipe of the collective medicine bottles after filling and capping. The activity detection valve and lower output valve are used to close the vertical sliding pipe of the collective medicine bottles at the activity meter well during activity detection. The vertical sliding pipe of the collective medicine bottles is sealed and connected to the upper and lower cavities of the activity meter well to close the activity meter well opening. The vertical sliding pipe of the collective medicine bottles is set at the middle of the inner cavity of the activity meter well to stop the release of the vertically sliding collective medicine bottles, providing the time and position conditions for detecting the activity of the collective medicine bottles after filling and capping. The air purification device in the top chamber can promptly carry the nuclear contaminated air generated in the workstation to the downstream disposal and treatment facilities that meet the regulations. The dispensing and capping device in the upper shielded chamber completes the dispensing and capping of the mother liquor bottles into the collective medicine bottles. After dispensing and capping, the collective medicine bottles, via a vertical sliding pipe, are transported from the dispensing and capping device to the bottle-dropping cap output device. During this descent, the collective medicine activity is temporarily stopped by a bottle-stopping mechanism within the activity meter well, thus completing the collective medicine activity test. After the activity test is completed, the dispensing and capping collective medicine bottles are released by the bottle-stopping mechanism and continue falling through the vertical sliding pipe into the collective medicine bottle protective container on the bottle-dropping cap output device. The bottle-dropping cap output device then attaches the matching protective cap and provides or outputs the protective cap and the collective medicine bottle protective container containing the dispensing and capping collective medicine bottles. In particular, the upper input valve and the lower output valve do not open simultaneously, or the upper input valve, the activity detection valve, and the lower output valve do not open simultaneously, ensuring that air does not leak out of the upper shielding chamber during the downward movement of the group of bottles after dispensing and capping. Furthermore, the air in the upper shielding chamber or both upper and lower shielding chambers can be refreshed and exhausted to safe disposal facilities through the air purification device in the top chamber. It integrates the functions of transferring the mother liquor bottle from the protective tank to the dispensing and capping of the group of bottles, as well as the activity detection of the dispensing and capping group of bottles, and the placement of protective caps on the group of bottles into a single unit. It boasts advantages such as high vertical integration and excellent protection.

[0027] Specifically, during activity testing, a temporary air suspension device located in the middle of the activity meter well temporarily stops the collective medicine bottle's vertical sliding pipe, or a temporary narrowing device located in the middle of the activity meter well temporarily stops the collective medicine bottle during activity testing. More specifically, the temporary air suspension device is a variable diameter pipe section located in the middle of the activity meter well's vertical sliding pipe. During activity testing, the collective medicine bottle is temporarily suspended at the variable diameter pipe section by an upward airflow or a downward airflow. After the upward airflow or downward airflow stops, the collective medicine bottle is released and continues to slide down. The temporary narrowing device temporarily narrows the collective medicine bottle's vertical sliding pipe in the middle of the activity meter well's inner cavity during activity testing, stopping the sliding collective medicine bottle. After the activity test is completed, the narrowed collective medicine bottle's vertical sliding pipe returns to its initial state, releasing the collective medicine bottle and allowing it to continue sliding down. Narrowing means that the inner diameter of the narrowed pipe is smaller than the outer diameter of the collective medicine bottle. The vertical drop-off pipeline for the collective medicine bottles is equipped with an upper bypass tee and a lower bypass tee located above and below the activity meter well, respectively, between the upper inlet valve or activity detection valve and the lower outlet valve. A bypass fan is installed on the bypass loop pipeline between the upper and lower bypass tees to generate an upward suction airflow or a downward blowing airflow at the variable diameter pipe section. The temporary narrowing device is a vertical connection between the upper and lower pipe sections of the vertical drop-off pipeline for the collective medicine bottles at the middle of the activity meter well cavity via a flexible hose or tubular cable. One section of the upper and lower pipe sections is a fixed section, and the other is a pivot section. The pivot section is equipped with a rotary drive mechanism that twists the flexible hose or cable during rotation. The flexible ropes, arranged in a spiral pattern, narrow their inner diameter to stop the vertically sliding collective medicine bottle. The bottle is released when the system is initially rotated to the next position. Alternatively, one section of the upper and lower tubes can be a fixed section while the other is a vertically sliding section. The vertically sliding section is equipped with a lifting drive mechanism. An elastic ring with a diameter smaller than the outer diameter of the collective medicine bottle is bound to the outer periphery of the flexible hose or tubular rope in the middle. When the lifting drive mechanism is in the rising position, the elastic ring binds the flexible hose or tubular rope, making their inner diameter smaller than the outer diameter of the collective medicine bottle, thus stopping the vertically sliding collective medicine bottle. When the lifting drive mechanism is in the descending position, the flexible hose or tubular rope is vertically straightened, widening its inner diameter to a size greater than the outer diameter of the collective medicine bottle, releasing the vertically sliding collective medicine bottle.

[0028] Specifically, the dispensing and capping device consists of an L-shaped base on the rear center of the upper shielded chamber floor, with an upstream metering and conveying valve control pipeline connecting to the mother liquor protection tank at the front. A filling head is located on one side of the lower part of the L-shaped base, connected to the downstream end of the metering and conveying valve control pipeline. A rotating filling robotic arm, which rotates between the waiting position and the filling position, is also located at the front of the upper extension of the upper part of the L-shaped base to the other side, or at the upper front of the rear extension of the L-shaped base to the other side. A downward capping machine is located at the capping position. A collection of medicine bottles is located at the rotating end between the filling position and the capping position on the other side of the lower part of the L-shaped base. The robotic arm supporting the group medicine bottle packaging is a swivel-lifting filling seat. The upper shielding chamber has two parallel through-holes on its transparent lead glass front screen. At least one of these through-holes is sealed by a shielding sleeve to accommodate a surgical laparoscopic gripper used for picking up and placing group medicine bottles and caps. The left side of the upper shielding chamber floor, from back to front, features a placement position for the mother liquor protection tank and a material lifting well for the mother liquor protection tank and the group medicine bottles with caps. The lifting well extends from the lower shielding chamber with a shielded front door to the lifting well opening. A placement station for the group medicine bottles with caps is located in front of the L-shaped base on the upper shielding chamber floor. The downward capping machine is a chuck-type capping machine. The surgical laparoscopic gripper picks up the group medicine bottles and places them into the group medicine bottle support at the end of the swivel-lifting filling seat type group medicine bottle packaging robotic arm located at the filling position. The metering and delivery valve-controlled pipeline quantitatively draws the medicine from the upstream mother liquor protection tank and inserts its filling head into the bottle opening on the bottle holder of the directional lifting-type collective bottle sealing support robot arm located at the filling position for quantitative filling. The directional filling robot arm fills the collective bottles at the filling position. When in the waiting position, the directional filling robot arm clears the collective bottles at the filling position to facilitate placement. The directional lifting-type collective bottle automatic sealing support robot arm receives the collective bottles at the filling position, providing conditions for accepting filling and also providing the prerequisite for the filled and capped collective bottles to slide down the vertical pipe. The caps are then applied to the filled collective bottles at the filling position using surgical laparoscopic grippers. Finally, the directional lifting-type collective bottle automatic sealing support robot arm presses down to seal the collective bottles in the capping position. The metering and delivery valve-controlled pipeline, the directional filling robotic arm, the downward capping machine, and the directional lifting filling seat-type automatic bottle sealing and support robotic arm are all intelligently controlled. The mother liquor protection tank is a 3.6mmPb total drug quantity protection tank after synthesis. The metering and delivery valve-controlled pipeline includes a main micro metering pump for outputting radionuclide drug and a secondary micro metering pump for injecting excipients into the output radionuclide drug as needed.

[0029] Specifically, two parallel through holes are respectively sealed with shielding sleeves for a left surgical laparoscopic gripper used to place capped bottles from the material lifting well to the bottle placement station, and a right surgical laparoscopic gripper used to place capped bottles from the bottle placement station to the bottle holder of the swivel-lifting filling seat type bottle sealing support robot arm, and to pick up and drop caps. The left and right surgical laparoscopic grippers are configured side-by-side, which reduces operational difficulty and improves operational accuracy compared to a single surgical laparoscopic gripper. The capped bottles are lightly placed on the top of the bottle. The front of the L-shaped base is located on one side, where the swivel-lifting filling seat type bottle sealing support robot arm's swivel lifting drive mechanism is installed. The downward filling head of the swivel filling robot arm corresponds vertically with the bottle holder at the end of the swivel-lifting filling seat type bottle sealing support robot arm at the filling position. This design helps ensure correct alignment between the sub-liquid bottle opening on the sub-liquid bottle holder and the downward filling head, simplifying operation. The upper shielding chamber's transparent lead glass front screen has left and right airtight lead glass doors located outside the two parallel through-holes. Each door is fitted with a left and right inner extension glove, which allows for easy extension of the arm to perform additional tasks while maintaining the airtightness of the upper shielding chamber. Above the left and right airtight lead glass doors, the upper shielding chamber's transparent lead glass front screen has a vertically oriented, angled transparent lead glass observation window, facilitating accurate observation of the internal conditions. A touch screen display is located at the lower front of the top chamber for convenient external observation and operation. A spare activity detection well is located on the right side of the upper shielding chamber's floor plate, allowing for activity testing of collective vials after non-standard filling and capping, meeting special activity testing needs. The lower shielding chamber is pivotally connected to the left and right transparent lead glass doors, facilitating maintenance of the internal equipment through these doors.

[0030] Specifically, airtight check valves that automatically close after ventilation stops are installed in series on the upstream and downstream ventilation ducts of the air duct where the clean air device is located. This ensures that after ventilation stops, polluted air discharged from the internal ducts will not flow back into the station, and conversely, backflowing air from the station will not flow back into the indoor space where the workstation is located. The airtight check valve consists of a medium-coarse expanded pipe section with axially sliding, hollowed-out supports spaced along its inner cavity. A forward-extending pipe seat is located in front of the rear hollowed-out support within the medium-coarse expanded pipe section. A valve plate, which is sealed and fixedly fitted onto the front end of the forward-extending pipe seat, is mounted on the central shaft. An elastic sealing plate, which seals and engages with the front end of the forward-extending pipe seat, is located behind the valve plate. A support spring is fitted over the central shaft between the valve plate and the front hollowed-out support. The front and rear hollowed-out supports provide more reliable and durable axial sliding support for the central shaft. The medium-thickness expanded pipe section features a front and rear hollowed-out support, an extended pipe seat, a valve plate with its elastic sealing plate, a central shaft, and its supporting spring. This design provides better fluid flow compared to pipe sections of the same or narrow diameter when the valve plate and its elastic sealing plate are away from the extended pipe seat, easily achieving a flow rate no lower than that of the connected pipeline itself. Because the extended pipe seat and valve plate are sealed by the elastic sealing plate under spring pressure, the narrow sealing contact surface not only facilitates sealing but also ensures high sealing performance and minimizes the risk of sealing failure. Therefore, it offers excellent fluid flow, high sealing efficiency, and easy self-opening and closing based on fluid flow. It is particularly suitable for the self-opening and closing control of negative pressure ventilation pipelines in artificial nuclear drug input / output to activity wells and dispensing hot chambers. Specifically, when negative or positive air pressure disappears, this medical one-way valve automatically and tightly seals the pipeline, preventing leakage of radioactive contaminant air.

[0031] Specifically, the elastic sealing sheet is a silicone elastic diaphragm. Compared with other elastic materials, silicone elastic diaphragms are less prone to contamination, have better elasticity, and are more durable, making them particularly suitable for press-fitting and sealing with the front end of the extension tube seat. The elastic sealing sheet is annular, minimizing gaps that could lead to residue between it and the valve plate. The inner ring of the annular elastic sealing sheet is sealed and secured to the valve plate by an annular pressure plate and its annularly distributed fastening pins, which, compared to adhesive bonding, does not affect or contaminate the flowing medication. Furthermore, the inner ring fixation provides better flowability than the outer ring fixation. The front hollow bracket is forward-mounted to accommodate the front protruding hollow barrel-shaped seat supporting the spring. This increases the spring length without increasing the distance between the front and rear hollow brackets, significantly optimizing the sealing opening performance under spring support, resulting in better reliability and operability. The front protruding hollow barrel-shaped seat is either a straight barrel shape or a conical barrel shape that is narrower at the front and wider at the back. Compared to a straight barrel shape, the conical barrel shape better restrains the front end of the supporting spring, improving sealing reliability. The inner cavity of the hollow conical barrel, which does not contact the supporting spring, facilitates flow. The extended tube seat is a trapezoidal tube wall type extended tube seat that is narrow at the front and wide at the back, which is easy to press together to achieve a reliable seal. It is also a ring-shaped knife-edge type extended tube seat that is thinner at the front and thicker at the back, which is even easier to press together to achieve a reliable seal. The trapezoid is either isosceles or right-angled. A right-angled trapezoid occupies less flow space than an isosceles trapezoid, while a small-angled isosceles trapezoid provides some elastic sealing support. The rear hollowed-out bracket has a forward-facing boss for fitting the base of the support spring, which provides good stability during spring extension and contraction, thus improving the sealing performance. The medium-thickness expanding tube section is formed by sealing and fastening a front expanding tube cap section with a front hollowed-out bracket and a rear expanding tube seat section with a rear hollowed-out bracket and an extended tube seat. This facilitates manufacturing, disassembly, and maintenance. The front expander cap section is a stepped, rear-extending flared section that is narrower at the front and wider at the back. The front hollowed-out support is located on the rear-extending flared section's middle rear-extending step, facilitating integral injection molding. The rear expander seat section is a convex annular, front-extending flared section that is wider at the front and narrower at the back. The rear hollowed-out support is located on the inner circumference of the convex ring in the middle of the front-extending flared section, and the front extender seat is positioned forward from the convex ring in the middle of the front-extending flared section. This also facilitates integral injection molding and allows for a more spacious flow path for the fluid. The front expander cap section is a rearward flared tube extending from a straight front end. The rear end of the rearward flared tube is connected to an outwardly extending ring platform with a front hollowed-out support. The outer circumference of the outwardly extending ring platform extends rearward to form a rearward tube seat for sealing and engaging with the rear expander seat section. The rear expander seat section is a forward flared tube extending from a straight rear end. The forward flared tube extends forward to form a forward tube seat for sealing and engaging with the front expander cap section. An inner convex ring is provided in the middle of the inner cavity of the forward flared tube, and the rear hollowed-out support is provided on the inner circumference of the inner convex ring. The forward extending tube seat is positioned forward from the inner convex ring. The inner and outer sleeve joint between the rear end of the rear tube seat and the front end of the front tube seat is sealed with a silicone sealing ring. The rear end of the rear tube seat and the front end of the front tube seat are screwed together. A silicone sealing ring is pressed between the front end of the inner sleeve tube seat and the inner ring platform of the outer sleeve tube seat, which facilitates disassembly and maintenance while ensuring a reliable sealing connection.The rearward-facing trumpet-shaped expander, with its extended annular platform and front hollowed-out support, increases fluid circulation space and ensures smooth flow. An inner convex ring is located in the middle of the inner cavity of the forward-facing trumpet-shaped expander, with the rear hollowed-out support positioned on its inner circumference. The forward-extending tube seat, positioned forward from the inner convex ring, ensures a tight seal while also increasing fluid circulation space and ensuring smooth flow. The rearward extension of the annular platform, used for sealing and engaging with the rear expander seat, and the forward extension of the trumpet-shaped expander, used for sealing and engaging with the front expander cap, facilitate a secure seal and increase flow space. The front and rear straight tube ports are used to connect upstream and downstream flow lines, especially medical lines. The connection can be a direct external connection or a threaded connection with a silicone sealing ring sealing the mating ring surface. It has the advantages of good fluid flow, high sealing efficiency, easy self-opening and closing by fluid, and is particularly suitable for the self-opening and closing control of the negative pressure ventilation pipeline of the artificial nuclear drug input and output to the activity well and the dispensing hot chamber. That is, when the negative or positive air pressure disappears, the pipeline will be automatically and tightly sealed by this medical one-way valve to prevent the leakage of radioactive contamination air.

[0032] The bottle-dropping and capping output device consists of a horizontal slide rail at the bottom of the chamber, connected to a horizontal slide frame and an extension push-pull frame. The base of the push-pull frame is equipped with an upward-facing protective canister support that faces the lower end of the vertical drop pipe for the collective medicine bottles when in the inner stop position. Any multiple protective canisters and vertical drop pipes for the collective medicine bottles are equipped with a buffer device to prevent damage to the bottles during their descent after filling and capping. Pushing the push-pull frame to the inner stop position ensures the upward-facing protective canister support faces the lower end of the vertical drop pipe, accurately receiving the filled and capped bottles. Pulling it outwards facilitates the fastening of the protective caps that fit the protective canister support. The buffer device for the bottles after filling and capping includes an upper open chamber in the protective canister containing the filled and capped bottles, equipped with an elastic cushioning pad, and a densely packed elastic support fiber within the vertical drop pipe to slow the downward speed of the bottles. The push-pull frame is equipped with a handle and a protective cap pushing mechanism, operated by a manual component within the handle, to push the protective caps onto the collective medicine bottle protective container holder. This mechanism ensures the pushed protective caps fall accurately onto the collective medicine bottle protective container. This manually operated cap pushing mechanism prevents the human body from being positioned above the upward-opening collective medicine bottle protective container when fastening the protective cap, thus avoiding unnecessary artificial nuclear radiation.

[0033] As shown in the figure, the artificial radionuclide drug dispensing method and dispensing workstation of the present invention, from top to bottom, consists of a top chamber 1 equipped with a clean air device 10, an upper shielded chamber 2 equipped with a dispensing and capping device, a lower shielded chamber 3 equipped with an activity meter well 30, and a bottom chamber 4 equipped with a bottle dropper and capping output device 41. From the dispensing and capping device in the upper shielded chamber 2 to the bottle dropper and capping output device 41 in the bottom chamber 4, a vertical sliding pipe 5 for conveying and detecting the activity of the filled and capped bottles downwards is provided through the inner cavity of the activity meter well 30. An upper input valve 51 and an activity detection valve are respectively provided on the upper part of the vertical sliding pipe 5 and above and below the activity meter well 30. The valve 53 controls the downward input / output of the collected medicine bottles 6 after filling and capping, and also controls the closure of the vertical sliding pipe 5 for activity testing. Alternatively, the vertical sliding pipe 5 can be equipped with an upper input valve and a lower output valve, respectively, to control the downward input / output of the collected medicine bottles after filling and capping. The vertical sliding pipe 5 is sealed to the upper and lower openings of the activity meter well 30 to close the activity meter well opening. The vertical sliding pipe 5 is located in the middle of the activity meter well 30, acting as a mechanism to stop and release the vertically sliding collected medicine bottles 6, providing the time and position conditions for detecting the activity of the collected medicine bottles after filling and capping. The air purification device in the top chamber can promptly transport the nuclear contaminated air generated in the workstation to downstream disposal and treatment facilities that meet regulations. The dispensing and capping device in the upper shielded chamber completes the dispensing and capping of the mother liquor bottles into the collective medicine bottles. After dispensing and capping, the collective medicine bottles, via a vertical sliding pipe, are transported from the dispensing and capping device to the bottle-dropping cap output device. During this descent, the collective medicine activity is temporarily stopped by a bottle-stopping mechanism within the activity meter well, thus completing the collective medicine activity test. After the activity test is completed, the dispensing and capping collective medicine bottles are released by the bottle-stopping mechanism and continue falling through the vertical sliding pipe into the collective medicine bottle protective container on the bottle-dropping cap output device. The bottle-dropping cap output device then attaches the matching protective cap and provides or outputs the protective cap and the collective medicine bottle protective container containing the dispensing and capping collective medicine bottles. In particular, the upper input valve and the lower output valve do not open simultaneously, or the upper input valve, the activity detection valve, and the lower output valve do not open simultaneously, ensuring that air does not leak out of the upper shielding chamber during the downward movement of the group of bottles after dispensing and capping. Furthermore, the air in the upper shielding chamber or both upper and lower shielding chambers can be refreshed and exhausted to safe disposal facilities through the air purification device in the top chamber. It integrates the functions of transferring the mother liquor bottle from the protective tank to the dispensing and capping of the group of bottles, as well as the activity detection of the dispensing and capping group of bottles, and the placement of protective caps on the group of bottles into a single unit. It boasts advantages such as high vertical integration and excellent protection.

[0034] Specifically, the collective medicine bottle release interception mechanism is a temporary air suspension device in which the collective medicine bottle vertical sliding pipe 5 is set at the middle position of the inner cavity of the activity meter well 30 to stop the collective medicine bottle during activity testing. Alternatively, it can be a temporary narrow channel device in which the collective medicine bottle vertical sliding pipe 5 is set at the middle position of the inner cavity of the activity meter well to stop the collective medicine bottle during activity testing.

[0035] The temporary air suspension device is a variable diameter tube section 50 installed in the middle of the inner cavity of the activity meter well 30 in the vertical sliding pipe 5 of the collective medicine bottle. During activity testing, the collective medicine bottle 6 is temporarily suspended at the variable diameter tube section 50 by the upward suction airflow or the downward blowing airflow. After the upward suction airflow and the downward blowing airflow are stopped, the collective medicine bottle 6 is released to continue sliding down. When the expanded diameter tube section is used, the bottom of the collective medicine bottle stops between the expanded diameter tube section and the lower vertical sliding pipe of the collective medicine bottle. When the narrow diameter tube section is used, the bottom of the collective medicine bottle stops between the upper vertical sliding pipe of the collective medicine bottle and the narrow diameter tube section. The vertical drop-off pipe 5 for the collective medicine bottles is connected between the activity detection valve 52 (or the upper input valve 51) and the lower output valve 53. An upper bypass tee and a lower bypass tee are respectively installed above and below the activity meter well 30. A bypass fan is installed on the bypass loop pipe between the upper and lower bypass tees to generate an upward suction airflow or a downward blowing airflow at the reducing pipe section 50. With the upper input valve or activity detection valve and the lower output valve simultaneously closed, this dedicated bypass fan generates the upward suction airflow or the downward blowing airflow.

[0036] The temporary narrowing device is used during activity testing to temporarily narrow the vertical sliding pipe 5 of the collective medicine bottles at the middle position of the activity meter well 30, stopping the sliding collective medicine bottles 6. After the activity test is completed, the narrowed vertical sliding pipe 5 returns to its initial state, releasing the collective medicine bottles 6 to allow them to continue sliding. Narrowing means that the inner diameter after narrowing is smaller than the outer diameter of the collective medicine bottles. The temporary narrowing device consists of the upper and lower pipe sections of the vertical sliding pipe 5 connected vertically at the middle position of the activity meter well 30 by a flexible hose or tubular cable 55. One section of the upper and lower pipe sections is fixed, and the other is a pivot section. The pivot section is equipped with a rotation drive mechanism. During rotation, the flexible hose or tubular cable 55 is twisted to narrow its inner diameter, stopping the vertically sliding collective medicine bottles. When the pipes return to the initial position, the vertically sliding collective medicine bottles are released. Alternatively, one section of the upper and lower pipe sections can be fixed, and the other can be a vertically sliding section. The vertical sliding section is equipped with a lifting drive mechanism. A flexible ring with a diameter smaller than the outer diameter of the collective medicine bottle 6 is bound to the outer periphery of the flexible hose or tubular cable 55. When the lifting drive mechanism is in the rising position, the elastic ring binds the flexible hose or tubular cable 55, making their inner diameter smaller than the outer diameter of the collective medicine bottle 6, thus stopping the vertical sliding of the collective medicine bottle. When the lifting drive mechanism is in the descending position, the flexible hose or tubular cable 55 is vertically straightened, widening their inner diameter to be larger than the outer diameter of the collective medicine bottle 6, releasing the vertically sliding collective medicine bottle. Whether stretching or rotating, the pivot section or vertical sliding section needs to be fitted with a movable sealing sleeve at the activity meter well 30. The movable sealing sleeve can be a loose annular sealing sleeve or an airtight sliding sleeve.

[0037] The dispensing and capping device consists of an L-shaped base 20 located on the middle rear of the bottom plate of the upper shielding chamber 2, with a metering and conveying valve control pipeline 21 connected upstream to the mother liquor protection tank 60 at the front of the upper part of the base 20. A filling head 71 is located on one side of the lower part of the L-shaped base 20, connected to a rotating filling robotic arm 7 at the downstream end of the metering and conveying valve control pipeline 21, which rotates between the waiting position and the filling position. A downward capping machine 70 is located on the front of the upper extension of the L-shaped base 20 to the other side or the upper extension of the rear of the L-shaped base 20 to the other side, which is positioned towards the capping position. The other side of the lower part of the L-shaped base 20 is located between the filling position and the capping position. The rotating end of the collective medicine bottle holder 80 is equipped with a swivel lifting filling seat type collective medicine bottle sealing and supporting robotic arm 8; the transparent lead glass front screen of the upper shielding chamber 2 has two parallel through holes, at least one of which is sealed by a shielding soft sleeve to fit a surgical laparoscopic gripper 23 for picking up and placing collective medicine bottles 6 and bottle caps. The left side of the bottom plate of the upper shielding chamber 2, from back to front, is equipped with the placement position of the mother liquor protection tank 60 and the material lifting well 88 of the mother liquor protection tank and the collective medicine bottles with bottle caps. The bottom plate of the upper shielding chamber 2 has a collective medicine bottle placement station 89 with bottle caps in front of the L-shaped base 20. The downward capping machine is a chuck-type capping machine. The surgical laparoscopic gripper picks up the collective medicine bottles and places them into the collective medicine bottle holder at the end of the swivel lifting filling seat type collective medicine bottle sealing and supporting robotic arm located at the filling position. The metering and delivery valve-controlled pipeline quantitatively draws the medicine from the upstream mother liquor protection tank and inserts its filling head into the bottle opening on the bottle holder of the directional lifting-type collective bottle sealing support robot arm located at the filling position for quantitative filling. The directional filling robot arm fills the collective bottles at the filling position. When in the waiting position, the directional filling robot arm clears the collective bottles at the filling position to facilitate placement. The directional lifting-type collective bottle automatic sealing support robot arm receives the collective bottles at the filling position, providing conditions for accepting filling and also providing the prerequisite for the filled and capped collective bottles to slide down the vertical pipe. The caps are then applied to the filled collective bottles at the filling position using surgical laparoscopic grippers. Finally, the directional lifting-type collective bottle automatic sealing support robot arm presses down to seal the collective bottles in the capping position. The metering and delivery valve-controlled pipeline, the directional filling robotic arm, the downward capping machine, and the directional lifting filling seat-type automatic bottle sealing and support robotic arm are all intelligently controlled. The mother liquor protection tank is a 3.6mmPb total drug quantity protection tank after synthesis. The metering and delivery valve-controlled pipeline 21 includes a main micro metering pump 28 for outputting radionuclide drug and a secondary micro metering pump 29 for injecting excipients into the output radionuclide drug as needed.

[0038] Specifically, two parallel through holes are respectively sealed with shielding sleeves for placing collective medicine bottles with caps from the medicine bottle material lifting well 88 to the medicine bottle placement station 89, and for placing and removing collective medicine bottles with caps from the medicine bottle placement station 89 to the collective medicine bottle holder 80 of the directional lifting filling seat type collective medicine bottle sealing support robot arm 8. The caps of the collective medicine bottles 6 are lightly pressed onto the top of the collective medicine bottles 6.

[0039] Specifically, the front of the L-shaped base 20 is equipped with a steering and lifting drive mechanism for the steering and lifting type of automatic packaging support robot arm 8 for collective medicine bottles, located on one side. The downward filling head 71 of the steering and filling robot arm 7 corresponds vertically to the collective medicine bottle support seat 80 at the end of the steering and lifting type of automatic packaging support robot arm 8. The upper shielding chamber 2 has a transparent lead glass front screen 22 with left and right airtight transparent lead glass doors 24 on the outside of the two parallel through holes. The left and right hand holes 25 inside the left and right airtight transparent lead glass doors 24 are sealed and fitted with left and right inner gloves. The upper shielding chamber 2 has a slanted transparent lead glass observation window 26 with a vertical line of sight above the left and right airtight lead glass doors 24. A touch screen 11 is installed at the front of the lower part of the top chamber 1. A spare activity detection well 301 is installed on the right side of the bottom plate of the upper shielding chamber 2. The lower shielding chamber 3 is pivotally connected to the left and right transparent lead glass doors 34.

[0040] Specifically, airtight check valves that automatically close after ventilation is stopped are installed in series on the upstream and downstream ventilation ducts of the ventilation duct where the clean air device 10 is located. Figure 11-12As shown, more specifically, the ventilation ducts of the upper shielding chamber 2 or the upper and lower shielding chambers 2 and 3 in the air duct where the clean air device 10 is located are respectively equipped with airtight check valves that automatically close after the air is stopped. The airtight check valve is a front hollow support 41 and a rear hollow support 42 of the axially sliding central shaft 40, which are arranged at intervals along the axis of the inner cavity of the medium-coarse expansion pipe section. A front extension pipe seat 43 is set in front of the rear hollow support 42 in the inner cavity of the medium-coarse expansion pipe section. A valve plate 44 is sealed and fixed on the central shaft 40 and fastened to the front end of the front extension pipe seat 43. An elastic sealing plate 45 is set behind the valve plate 44 and sealed and fastened to the front end of the front extension pipe seat 43. A support spring 46 is sleeved between the central shaft 40 and the valve plate 44 and the front hollow support 21. The front and rear hollow supports can provide more reliable and durable axial sliding support for the central shaft. The medium-thickness expanded pipe section features a front and rear hollowed-out support, an extended pipe seat, a valve plate with its elastic sealing plate, a central shaft, and its supporting spring. This design provides better fluid flow compared to pipe sections of the same or narrow diameter when the valve plate and its elastic sealing plate are away from the extended pipe seat, easily achieving a flow rate no lower than that of the connected pipeline itself. Because the extended pipe seat and valve plate are sealed by the elastic sealing plate under spring pressure, the narrow sealing contact surface not only facilitates sealing but also ensures high sealing performance and minimizes the risk of sealing failure. Therefore, it offers excellent fluid flow, high sealing efficiency, and easy self-opening and closing based on fluid flow. It is particularly suitable for the self-opening and closing control of negative pressure ventilation pipelines in artificial nuclear drug input / output to activity wells and dispensing hot chambers. Specifically, when negative or positive air pressure disappears, this medical one-way valve automatically and tightly seals the pipeline, preventing leakage of radioactive contaminant air.

[0041] The elastic sealing sheet 45 is a silicone elastic diaphragm. More specifically, the elastic sealing sheet 45 is an annular sheet. The inner ring of the annular sheet elastic sealing sheet 45 is sealed and fastened to the valve plate 44 by an annular pressure plate 47 and its annularly distributed fastening pins. The front hollow bracket 41 is provided forward to accommodate the front part of the supporting spring 46 with a forward-convex hollow barrel-shaped seat 48. The forward-convex hollow barrel-shaped seat 48 is a conical barrel shape that is narrower at the front and wider at the back, or it can be a straight barrel shape. The front extension tube seat 43 is a trapezoidal tube wall type front extension tube seat 43 that is narrower at the front and wider at the back. More specifically, it is an annular blade type front extension tube seat that is narrower at the front and wider at the back. Preferably, the trapezoid is an isosceles or right-angled trapezoid. More preferably, it is a right-angled trapezoid. The rear hollow bracket 31 is provided forward to accommodate the front boss 49 of the supporting spring base. The medium-thickness expanding pipe section is formed by sealing and fastening a front expanding pipe cap section 33 with a front hollow support and a rear expanding pipe seat section 34 with a rear hollow support and a front extending pipe seat. More specifically, the front expanding pipe cap section 33 is a rear extending flared section with a stepped rear opening that is thinner at the front and thicker at the back, and the front hollow support 41 is set in the rear inward step in the middle of the rear extending flared section; the rear expanding pipe seat section 34 is a front extending flared section with a thicker front and thinner rear, and the rear hollow support 42 is set in the inner circumference of the inner convex ring 35 in the middle of the front extending flared section, and the front extending pipe seat 43 is set forward from the inner convex ring 35 in the middle of the front extending flared section. The front expander cap section 33 is a rearward flared expander extending from a straight front end. An outwardly extending ring platform with a front hollowed-out support extends from the rear end of the rearward flared expander. The outer circumference of the outwardly extending ring platform extends rearward to form a rearward pipe seat for sealing and engaging with the rear expander seat section 34. The rear expander seat section 34 is a forward flared expander extending from a straight rear end. The forward flared expander extends forward to form a forward pipe seat for sealing and engaging with the front expander cap section 33. An inner convex ring 35 is provided in the middle of the inner cavity of the forward flared expander. The rear hollowed-out support is provided on the inner circumference of the inner convex ring 35, and the forward extending pipe seat 43 is positioned forward from the inner convex ring 35. The inner and outer sleeve joint between the rear end of the rear pipe seat and the front end of the front pipe seat is sealed with a silicone sealing ring. The rear end of the rear pipe seat and the front end of the front pipe seat are screwed together, and a silicone sealing ring is pressed between the front end of the inner sleeve pipe seat and the inner ring platform of the outer sleeve pipe seat. The front and rear straight inlets are used to extend the upstream and downstream circulation pipelines 36, especially medical pipelines. The extension can be a direct outer connection or a connection via internal thread, with the mating rings sealed by a silicone sealing ring.

[0042] Specifically, the bottle cap output device is a horizontal slide rail 91 at the bottom of the bottom chamber 4, connected to a push-pull frame 9 via a horizontal slide 90. The base of the push-pull frame 9 is equipped with an upward-facing collective medicine bottle protective can holder that faces the lower end of the vertical sliding pipe 5 of the collective medicine bottles from the inner stop position. Any multiple collective medicine bottle protective cans and collective medicine bottle vertical sliding pipes are equipped with a buffer device for the collective medicine bottles after filling and capping. This buffer device includes an upper open chamber in the collective medicine bottle protective can for accommodating the filled and capped collective medicine bottles, equipped with an elastic buffer sleeve, and an inner cavity of the collective medicine bottle vertical sliding pipe equipped with elastic densely distributed support fibers to slow the downward speed of the filled and capped collective medicine bottles. The push-pull frame 9 is externally equipped with a handle and a protective cap pushing mechanism controlled by a manual component to push the protective cap onto the collective medicine bottle protective can 99 on the upward-facing collective medicine bottle protective can holder. This pushing mechanism ensures that the pushed protective cap falls accurately onto the collective medicine bottle protective can 99.

[0043] In summary, the artificial radionuclide drug dispensing method and dispensing workstation of the present invention have the advantages of integrating the functions of dispensing and sealing the mother liquor bottle from the protective container to the collective drug bottle, performing activity detection on the collective drug bottle after dispensing and sealing, and adding protective caps to the collective drug bottle protective container. It has a high degree of vertical integration and good protection.

Claims

1. A method for dispensing artificial radionuclide drugs, characterized in that... This system utilizes a top chamber equipped with a clean air system, an upper shielded chamber with a dispensing and capping device, a lower shielded chamber with an activity meter well, and a bottom chamber with a bottle drop and capping output device. A vertical drop pipe for the collective medicine bottles, passing through the inner cavity of the activity meter well, is installed from the dispensing and capping device in the upper shielded chamber to the bottle drop and capping output device in the bottom chamber. This pipe facilitates the downward transport and activity testing of the filled and capped collective medicine bottles. An upper input valve and a lower output valve are respectively installed at the top and bottom of the vertical drop pipe, or an upper input valve and an activity testing valve are respectively installed at the top of the vertical drop pipe and above and below the activity meter well. The lower output valve, upper input valve, and lower output valve are used to control the input and output of the collective medicine bottles in the vertical sliding pipe of the collective medicine bottles after filling and capping. The activity detection valve and the lower output valve are used to close the vertical sliding pipe of the collective medicine bottles at the activity meter well during activity detection. The vertical sliding pipe of the collective medicine bottles is sealed and connected to the upper and lower cavities of the activity meter well to close the activity meter well opening. The vertical sliding pipe of the collective medicine bottles is equipped with a collective medicine bottle interception and release mechanism located in the middle of the inner cavity of the activity meter well to stop the release of the vertically sliding collective medicine bottles, providing time and position conditions for detecting the activity of the collective medicine bottles after filling and capping. During activity testing, the collective medicine bottle vertical drop pipe is temporarily stopped by a temporary air suspension device located in the middle of the activity meter well cavity, which serves as the collective medicine bottle release interception mechanism. Alternatively, during activity testing, the collective medicine bottle vertical drop pipe is temporarily stopped by a temporary narrow channel device located in the middle of the activity meter well cavity, which serves as the collective medicine bottle release interception mechanism. The temporary air suspension device includes a variable diameter tube section installed in the middle of the activity meter well cavity of the collective medicine bottle vertical sliding pipe. During activity detection, the collective medicine bottle is temporarily suspended at the variable diameter tube section by the upward suction airflow or the downward blowing airflow. After the upward suction airflow and the downward blowing airflow are stopped, the collective medicine bottle is released and it continues to slide down. During activity testing, a temporary narrowing device located in the middle of the activity meter well temporarily narrows the vertical sliding pipe of the collective medicine bottle to stop the sliding of the collective medicine bottle. After the activity test is completed, the temporary narrowing device restores the narrowed vertical sliding pipe of the collective medicine bottle to its initial state, releasing the collective medicine bottle so that it can continue to slide down.

2. The method for dispensing artificial radionuclide drugs according to claim 1, characterized in that... The dispensing and capping device consists of an L-shaped base located on the rear center of the upper shielding chamber floor. An upstream metering and conveying valve control pipeline connecting to the mother liquor protection tank is installed at the front of the upper part of the L-shaped base. A filling head is installed on one side of the lower part of the L-shaped base, connecting to a directional filling robotic arm at the downstream end of the metering and conveying valve control pipeline, which rotates between the waiting position and the filling position. A downward capping machine is installed at the front of the upper extension of the upper part of the L-shaped base to the other side, or at the upper front of the upper extension of the rear part of the L-shaped base to the other side, for the downward capping position. A collective medicine bottle holder is installed at the rotating end of the lower part of the L-shaped base, located between the filling position and the capping position. The robotic arm supports the swivel-lifting filling seat for packaging and sealing collective medicine bottles. The transparent lead glass front screen of the upper shielding chamber has two parallel through holes. At least one of the two parallel through holes is sealed with a surgical laparoscopic gripper for picking up and placing collective medicine bottles and caps through a shielding soft sleeve. The mother liquor protection tank and the material lifting well for the mother liquor protection tank and the collective medicine bottles with caps are set from back to front on the left side of the bottom plate of the upper shielding chamber. The lifting well is raised and lowered from the lower shielding chamber with the shielded front door to the lifting well opening. The collective medicine bottle placement station with caps is set in front of the L-shaped base on the bottom plate of the upper shielding chamber.

3. The method for dispensing artificial radionuclide drugs according to claim 1, characterized in that... The bottle-dropping capping output device is a horizontal slide rail at the bottom of the chamber, connected to a horizontal slide frame and a push-pull frame. The base of the push-pull frame is provided with an upward collective medicine bottle protective can support that is directly facing the lower end of the collective medicine bottle vertical sliding pipe at the inner stop position. Any or multiple collective medicine bottle protective cans and collective medicine bottle vertical sliding pipes are provided with a collective medicine bottle falling buffer device after filling and capping to avoid damage when the collective medicine bottles fall after filling and capping.

4. A dispensing workstation for implementing the artificial radionuclide dispensing method of claim 1, characterized in that... From top to bottom, the system consists of a top chamber equipped with a clean air system, an upper shielded chamber with a dispensing and capping device, a lower shielded chamber with an activity meter well, and a bottom chamber with a bottle drop and capping output device. From the dispensing and capping device in the upper shielded chamber to the bottle drop and capping output device in the bottom chamber, a vertical drop pipe for transporting and testing the filled and capped bottles downwards is installed, passing through the inner cavity of the activity meter well. The vertical drop pipe has an upper input valve and a lower output valve, respectively, for controlling the downward input and output of the filled and capped bottles or the vertical drop of the bottles. An upper input valve, an activity detection valve, and a lower output valve are respectively installed on the upper part of the sliding pipe and above and below the activity meter well. After filling and capping, the downward input and output control of the collective medicine bottle and the sealing control of the vertical sliding pipe of the collective medicine bottle during activity detection are combined. The vertical sliding pipe of the collective medicine bottle is sealed and connected to the upper and lower cavities of the activity meter well to seal the activity meter well opening. The vertical sliding pipe of the collective medicine bottle is set at the middle position of the inner cavity of the activity meter well to stop and release the vertically sliding collective medicine bottle, which provides time and position conditions for detecting the activity of the collective medicine bottle after filling and capping. The bottle-dropping cap output device is a horizontal slide rail at the bottom of the chamber, which is equipped with a horizontal slide frame and a push-pull frame that extends thereto. The base of the push-pull frame is provided with an upward collective medicine bottle protective can support that is directly facing the lower port of the collective medicine bottle vertical sliding pipe at the inner stop position. Any multiple collective medicine bottle protective cans and collective medicine bottle vertical sliding pipes are provided with a collective medicine bottle falling buffer device after filling and capping.

5. The dispensing workstation according to claim 4, characterized in that... The dispensing and capping device consists of an L-shaped base located on the rear center of the upper shielding chamber floor. An upstream metering and conveying valve control pipeline connecting to the mother liquor protection tank is installed at the front of the upper part of the L-shaped base. A filling head is installed on one side of the lower part of the L-shaped base, connecting to a directional filling robotic arm at the downstream end of the metering and conveying valve control pipeline, which rotates between the waiting position and the filling position. A downward capping machine is installed at the front of the upper extension of the upper part of the L-shaped base to the other side, or at the upper front of the upper extension of the rear part of the L-shaped base to the other side, for the downward capping position. The other side of the lower part of the L-shaped base is located between the filling position and the capping position. The rotating end is equipped with a rotating lifting filling seat type collective medicine bottle sealing and supporting robotic arm; the transparent lead glass front screen of the upper shielding chamber is provided with two parallel through holes, at least one of the two parallel through holes is sealed by a shielding soft sleeve to fit a surgical laparoscopic gripper for picking up and putting down collective medicine bottles and bottle caps; the left side of the bottom plate of the upper shielding chamber is provided with the mother liquor protection tank placement position and the mother liquor protection tank and the collective medicine bottle material lifting well with bottle caps from back to front; the bottom plate of the upper shielding chamber is provided with the collective medicine bottle with bottle caps placement station in front of the L-shaped base.

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